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Set Analyses:

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SPSB4 Gene

protein-coding GIFtS: 49
GCID: GC03P140770

SplA/Ryanodine Receptor Domain And SOCS Box Containing 4

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
SplA/Ryanodine Receptor Domain And SOCS Box Containing 4¹ ²
SSB4² ³ ⁵
SSB-4² ³
SPRY Domain-Containing SOCS Box Protein 4²
SPRY Domain-Containing SOCS Box Protein SSB-4²

External Ids:	HGNC: 30630¹	Entrez Gene: 92369²	Ensembl: ENSG00000175093⁷	OMIM: 611660⁵	UniProtKB: Q96A44³

Export aliases for SPSB4 gene to outside databases

Previous GC identifers: GC03P142253 GC03P138145

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPSB4 Gene:

SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) is a protein-coding gene. Diseases associated with SPSB4 include brucellosis, and hepatitis. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44

Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3

ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of

target proteins

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000003.12 NC_018914.2 NT_005612.17

Regulatory elements:

Regulatory transcription factor binding sites in the SPSB4 gene promoter:
NF-1/L NF-1 Spz1 Lmo2 HSF1 (long) XBP-1 Nkx6-1 HSF1short Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPSB4 promoter sequence

Search Chromatin IP Primers for SPSB4

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPSB4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23

SPSB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPSB4 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P140770: view genomic region (about GC identifiers)

Start:	140,770,244 bp from pter	End:	140,867,453 bp from pter
Size:	97,210 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44 (See protein sequence)

Recommended Name: SPRY domain-containing SOCS box protein 4

Size: 273 amino acids; 30179 Da

Subunit: Interacts with PARW (By similarity). Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase

complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4. Interacts with MET

1 PDB 3D structure from and Proteopedia for SPSB4:

2V24 (3D)

Explore the universe of human proteins at neXtProt for SPSB4: NX_Q96A44

Explore proteomics data for SPSB4 at MOPED

See SPSB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_543138.1

ENSEMBL proteins:

ENSP00000311609 ENSP00000422034

Reactome Protein details: Q96A44

SPSB4 Human Recombinant Protein Products:

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	Cloud-Clone Corp. ELISAs for SPSB4 Cloud-Clone Corp. CLIAs for SPSB4

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:

IPR001870 B30.2/SPRY

IPR003877 SPRY_rcpt

IPR001496 SOCS_C

IPR018355 SPla/RYanodine_receptor_subgr

IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q96A44

ProtoNet protein and cluster: Q96A44

1 Blocks protein domain: IPB001496 SOCS protein

UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44

Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different

E3 ubiquitin ligase complexes (By similarity)

Similarity: Belongs to the SPSB family

Similarity: Contains 1 B30.2/SPRY domain

Similarity: Contains 1 SOCS box domain

SPSB4 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: SPSB4_HUMAN, Q96A44

Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3

ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of

target proteins

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15601820

SPSB4 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPSB4

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPSB4

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPSB4

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPSB4

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		Selected qRT-PCR Assays for microRNAs that regulate SPSB4 (see all 38):
		hsa-miR-4307 hsa-miR-15a hsa-miR-29a hsa-miR-632 hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-1298

		SwitchGear 3'UTR luciferase reporter plasmid: SPSB4 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SPSB4
		Predesigned siRNA for gene silencing in human, mouse, rat SPSB4

Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

SPSB4_HUMAN, Q96A44: Cytoplasm (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
nucleus	2
mitochondrion	1

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

SPSB4 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SPSB4 About

See pathways by source

SuperPath

Contained pathways About

Class I MHC mediated antigen processing and presentation

	Class I MHC mediated antigen processing and presentation	0.84			Adaptive Immune System	0.41
	Antigen processing- Ubiquitination and Proteasome degradation	0.84

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for SPSB4

Antigen processing: Ubiquitination & Proteasome degradation

UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44

Pathway: Protein modification; protein ubiquitination

SPSB4 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Array including SPSB4:

Ubiquitin Ligases in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for SPSB4

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for SPSB4 (Q96A44^{1, 3} ENSP00000311609⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TCEB1	Q15369¹^,³, ENSP00000284811⁴	EBI-2323233,EBI-301231 I2D: score=2 STRING: ENSP00000284811
NOS2	P35228³, ENSP00000327251⁴	I2D: score=1 STRING: ENSP00000327251
RNF7	Q9UBF6³, ENSP00000273480⁴	I2D: score=1 STRING: ENSP00000273480
TCEB2	Q15370³, ENSP00000262306⁴	I2D: score=1 STRING: ENSP00000262306
CUL5	Q93034³	I2D: score=1

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016567	protein ubiquitination	IEA	--
GO:0035556	intracellular signal transduction	IEA	--

SPSB4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SPSB4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for SPSB4 gene:

NM_080862.1

Unigene Cluster for SPSB4:

SplA/ryanodine receptor domain and SOCS box containing 4

Hs.655112 [show with all ESTs]

Unigene Representative Sequence: BC051354

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310546(uc003ett.3 uc010hum.3) ENST00000508126 ENST00000508828

ENST00000507895

miRNA Products:		Block miRNA regulation of human, mouse, rat SPSB4 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate SPSB4 (see all 38):
		hsa-miR-4307 hsa-miR-15a hsa-miR-29a hsa-miR-632 hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-1298

		SwitchGear 3'UTR luciferase reporter plasmid: SPSB4 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat SPSB4

Clone Products:		OriGene clones in human, mouse for SPSB4 (see all 6) OriGene ORF clones in mouse, rat for SPSB4 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SPSB4 (NM_080862)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPSB4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB4

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4
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		QuantiTect SYBR Green Assays in human, mouse, rat SPSB4
		QuantiFast Probe-based Assays in human, mouse, rat SPSB4

Additional mRNA sequence:

AF086345.1 AF403029.1 AK056147.1 AK056367.1 BC008324.1 BC051354.1

4 DOTS entries:

DT.97791370 DT.100684548 DT.309089 DT.433213

Selected AceView cDNA sequences (see all 46):

AW293029 BM929361 AA757366 CR613017 AI369332 CR593903 AA581737 AA405736

BX351403 AF403029 BG826825 AI598224 W72267 AF086345 BG829052 NM_080862

AW411014 AA405968 BX112094 BC008324 AI277923 AK056367 BE261590 AI190669

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SPSB4 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6
SP1:							-		-
SP2:							-		-		-
SP3:

ECgene alternative splicing isoforms for SPSB4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPSB4 expression in normal human tissues (normalized intensities) SPSB4 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GGGGCAGCCT

About this image

SPSB4 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Neurons
nGnG Amacrine Cells Inner Nuclear Layer

Eye (Sensory Organs) fully expand to see all 2 entries
nGnG Amacrine Cells Inner Nuclear Layer

Lung (Respiratory System)
Basal Cells Trachea

Liver (Hepatobiliary System)
Mesothelial Cells Hepatic Mesenchyme

Brain (Nervous System)
Adult Oligodendrocyte Precursor Cells Lateral Ventricle

SPSB4 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SPSB4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.655112

Pathway & Disease-focused RT² Profiler PCR Array including SPSB4:

Ubiquitin Ligases in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat SPSB4
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		QuantiFast Probe-based Assays in human, mouse, rat SPSB4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SPSB4 gene from Selected species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spsb4^{1 , 5}	splA/ryanodine receptor domain and SOCS box containing more^{1, 5}	88.03(n)¹ 97.8(a)¹		9 (50.74 cM)⁵ 211949¹ NM_145134.3¹ NP_660116.1¹ 96943482⁵
chicken (Gallus gallus)	Aves	SPSB4¹	splA/ryanodine receptor domain and SOCS box containing more	71.31(n) 81.32(a)		429129 XM_426685.3 XP_426685.2
lizard (Anolis carolinensis)	Reptilia	SPSB4⁶	splA/ryanodine receptor domain and SOCS box contai...	82(a)	1 ↔ 1	GL343404.1(631397-710596)
tropical clawed frog (Xenopus tropicalis)	Amphibia	spsb4¹	splA/ryanodine receptor domain and SOCS box containing more	69.35(n) 80.59(a)		100496912 XM_002941296.2 XP_002941342.1
zebrafish (Danio rerio)	Actinopterygii	nszf-e326²	nszf-e326	73.91(n)		335778 CF996573.1
fruit fly (Drosophila melanogaster)	Insecta	gus¹	gustavus	58.21(n) 69.49(a)		35478 NM_165420.3 NP_724400.2
worm (Caenorhabditis elegans)	Secernentea	spsb-1¹	spsb-1	57.83(n) 58.5(a)		266876 NM_064920.4 NP_497321.3

ENSEMBL Gene Tree for SPSB4 (if available)
TreeFam Gene Tree for SPSB4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for SPSB4 gene

SPSB2² FBXO45² SPSB1²

Selected SIMAP similar genes for SPSB4 using alignment to 2 protein entries: SPSB4_HUMAN (see all proteins) (see all similar genes):

COX7A2 IPO7 ZNF568 ZNF83 SPSB1 ZNF738

TMEM67 ECD CES4A THADA IFT122 TGFBR3

C12orf23 DAPK2 NDUFS7 NSD1 SENP7 ZNF23

SPSB4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs191720465^1,2		--	138143615(+)	`CAGGGC/TATCCA`	1	--	int¹		0	--	--	--	--
rs184636448^1,2		--	138143730(+)	`AATACG/TTGTCA`	1	--	int¹		0	--	--	--	--
rs112398078^1,2	C,F	--	138143738(+)	`TCAATG/ACACAC`	1	--	int¹		1		CSA	2
rs148809283^1,2		--	138143863(+)	`GGTCTC/TTCTGG`	1	--	int¹		0	--	--	--	--
rs142457710^1,2		--	138143891(+)	`GTCACC/TACCCT`	1	--	int¹		0	--	--	--	--
rs188958536^1,2		--	138143895(+)	`CTACCC/TTGGTT`	1	--	int¹		0	--	--	--	--
rs151314838^1,2		--	138143968(+)	`GACACC/GGTCCA`	1	--	int¹		0	--	--	--	--
rs139366808^1,2		--	138143987(+)	`GTTCCC/GTCATA`	1	--	int¹		0	--	--	--	--
rs193268635^1,2	C	--	138143996(+)	`TACCCA/CCTCTG`	1	--	int¹		0	--	--	--	--
rs150028328^1,2		--	138144145(+)	`CCAGAA/GCCTCT`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPSB4 (140770244 - 140867453 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for SPSB4: About this table

Variant ID	Type	Subtype	PubMed ID
esv22188	CNV	Loss	19812545
nsv877550	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SPSB4

DNA2.0 Custom Variant and Variant Library Synthesis for SPSB4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611660 OMIM disorders: --

3 diseases for SPSB4: About MalaCards

brucellosis hepatitis malaria

SPSB4 for disorders About GeneDecksing

Genetic Association Database (GAD): SPSB4
Human Genome Epidemiology (HuGE) Navigator: SPSB4 (1 document)

Export disorders for SPSB4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SPSB4 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with SPSB4)

Utopia: connect your pdf to the dynamic
world of online information

The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)^{1, 2, 9} Wang D.... Wu G. (J. Biol. Chem. 2005)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)^{1, 2} Kamura T.... Nakayama K.I. (Genes Dev. 2004)
The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)^{1, 3} Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. (PubMed id 23041239)¹ Traylor M....Markus H.S. (Lancet Neurol 2012)
Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PubMed id 21199876)¹ Nishiya T....Miwa S. (J. Biol. Chem. 2011)
The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. (PubMed id 20603330)¹ Kuang Z....Nicholson S.E. (J. Cell Biol. 2010)
Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. (PubMed id 20561531)¹ Filippakopoulos P....Bullock A.N. (J. Mol. Biol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 92369	HGNC: 30630	AceView: SSB4	Ensembl:ENSG00000175093	euGenes: HUgn92369
ECgene: SPSB4	H-InvDB: SPSB4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SPSB4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPSB4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SPSB4 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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SplA/Ryanodine Receptor Domain And SOCS Box Containing 4

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SplA/Ryanodine Receptor Domain And SOCS Box Containing 4

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