Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPSB4 Gene

protein-coding   GIFtS: 50
GCID: GC03P140770

SplA/Ryanodine Receptor Domain And SOCS Box Containing 4
  1 related disease
at
MalaCards
 

Aliases
for SPSB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
SplA/Ryanodine Receptor Domain And SOCS Box Containing 41 2
SSB42 3 5
SSB-42 3
SPRY Domain-Containing SOCS Box Protein 42
SPRY Domain-Containing SOCS Box Protein SSB-42

External Ids:    HGNC: 306301   Entrez Gene: 923692   Ensembl: ENSG000001750937   OMIM: 6116605   UniProtKB: Q96A443   

Export aliases for SPSB4 gene to outside databases

Previous GC identifers: GC03P142253 GC03P138145


Summaries
for SPSB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for SPSB4 Gene: 
SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) is a protein-coding gene. Diseases associated with SPSB4 include brucellosis, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include protein binding. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins




Genomic Views
for SPSB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPSB4 gene promoter:
         NF-1/L   NF-1   Spz1   Lmo2   HSF1 (long)   XBP-1   Nkx6-1   HSF1short   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPSB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPSB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPSB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

SPSB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPSB4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P140770:  view genomic region     (about GC identifiers)

Start:
 140,770,244 bp from pter      End:
 140,867,453 bp from pter
Size:
 97,210 bases      Orientation:
 plus strand

Proteins
for SPSB4 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44 (See protein sequence)
Recommended Name: SPRY domain-containing SOCS box protein 4  
Size: 273 amino acids; 30179 Da
Subunit: Interacts with PARW (By similarity). Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase
complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4. Interacts with MET
Subcellular location: Cytoplasm (Probable)
1 PDB 3D structure from and Proteopedia for SPSB4:
2V24 (3D)    

Explore the universe of human proteins at neXtProt for SPSB4: NX_Q96A44

Explore proteomics data for SPSB4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A44

    • SPSB4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPSB4 Protein Expression
    REFSEQ proteins: NP_543138.1  
    ENSEMBL proteins: 
     ENSP00000311609   ENSP00000422034  
    Reactome Protein details: Q96A44
    Human Recombinant Protein Products for SPSB4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SPSB4
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for SPSB4 
    OriGene Custom Protein Services for SPSB4
    GenScript Custom Purified and Recombinant Proteins Services for SPSB4
    Novus Biologicals SPSB4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPSB4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SPSB4 for ontologies           About GeneDecksing



    SPSB4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPSB4
    GenScript Custom Superior Antibodies Services for SPSB4
    Search for Antibodies for SPSB4 at Abcam
    Cloud-Clone Corp. Antibodies for SPSB4 
    Search ThermoFisher Antibodies for SPSB4
    Search LSBio for Antibodies for SPSB4 

    Assay Products for SPSB4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPSB4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPSB4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPSB4 
    Cloud-Clone Corp. CLIAs for SPSB4

    Protein Domains /
    Families
    for SPSB4 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 5 InterPro protein domains:
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR001496 SOCS_C
     IPR018355 SPla/RYanodine_receptor_subgr
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q96A44

    ProtoNet protein and cluster: Q96A44

    1 Blocks protein domain: IPB001496 SOCS protein

    UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity)
    Similarity: Belongs to the SPSB family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 SOCS box domain


    SPSB4 for domains           About GeneDecksing


    Function
    for SPSB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPSB4_HUMAN, Q96A44
    Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15601820
         
    SPSB4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPSB4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPSB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPSB4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPSB4 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPSB4
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate SPSB4 (see all 38):
    hsa-miR-4307 hsa-miR-15a hsa-miR-29a hsa-miR-632 hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmid: SPSB4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPSB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPSB4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPSB4
    Sirion Biotech Customized adenovirus for overexpression of SPSB4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SPSB4 (see all 7)
    OriGene ORF clones in mouse, rat for SPSB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPSB4 (NM_080862)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPSB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB4
    Sirion Biotech Customized lentivirus for stable overexpression of SPSB4 
                         Customized lentivirus expression plasmids for stable overexpression of SPSB4 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SPSB4
    Search LifeMap BioReagents cell lines for SPSB4
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4


    Pathways & Interactions
    for SPSB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPSB4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation0.83
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System0.56
    		Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SPSB4
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44
    Pathway: Protein modification; protein ubiquitination


    SPSB4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPSB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for SPSB4 (Q96A441, 3 ENSP000003116094) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCEB1Q153691, 3, ENSP000002848114EBI-2323233,EBI-301231 I2D: score=2 STRING: ENSP00000284811
    NOS2P352283, ENSP000003272514I2D: score=1 STRING: ENSP00000327251
    RNF7Q9UBF63, ENSP000002734804I2D: score=1 STRING: ENSP00000273480
    TCEB2Q153703, ENSP000002623064I2D: score=1 STRING: ENSP00000262306
    CUL5Q930343I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    SPSB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPSB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPSB4

    Search CenterWatch for drugs/clinical trials and news about SPSB4

    Transcripts
    for SPSB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPSB4 gene: 
    NM_080862.1  

    Unigene Cluster for SPSB4:

    SplA/ryanodine receptor domain and SOCS box containing 4
    Hs.655112  [show with all ESTs]
    Unigene Representative Sequence: BC051354
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310546(uc003ett.3 uc010hum.3) ENST00000508126 ENST00000508828
    ENST00000507895
    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPSB4
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate SPSB4 (see all 38):
    hsa-miR-4307 hsa-miR-15a hsa-miR-29a hsa-miR-632 hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-1298
    SwitchGear 3'UTR luciferase reporter plasmid: SPSB4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPSB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPSB4
    Clone
    Products:             		 OriGene clones in human, mouse for SPSB4 (see all 7)
    OriGene ORF clones in mouse, rat for SPSB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPSB4 (NM_080862)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPSB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB4
    Sirion Biotech Customized lentivirus for stable overexpression of SPSB4 
                         Customized lentivirus expression plasmids for stable overexpression of SPSB4 
    Primer
    Products:            		OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPSB4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPSB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB4

    Additional mRNA sequence: 

    AF086345.1 AF403029.1 AK056147.1 AK056367.1 BC008324.1 BC051354.1 

    4 DOTS entries:

    DT.97791370  DT.100684548  DT.309089  DT.433213 

    24/46 AceView cDNA sequences (see all 46):

    AW293029 AI369332 AA581737 CR613017 AA757366 BM929361 CR593903 NM_080862 
    W72267 AW411014 AI277923 AI190669 BG826825 BU849123 AK056147 BC008324 
    BX112094 BM977987 AA581718 AF403029 BE041628 AI598224 AA308601 AI953088 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPSB4    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                    -     -               
    SP2:                    -     -     -         
    SP3:                                          


    ECgene alternative splicing isoforms for SPSB4

    Expression
    for SPSB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPSB4 expression in normal human tissues (normalized intensities)      SPSB4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGCAGCCT
    SPSB4 Expression
    About this image


    SPSB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
             Mesothelial Cells Hepatic Mesenchyme
     
     Brain (Nervous System)
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle

    See SPSB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPSB4

    SOURCE GeneReport for Unigene cluster: Hs.655112
        SABiosciences Expression via Pathway-Focused PCR Array including SPSB4: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:    		OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPSB4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPSB4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB4
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4

    Orthologs
    for SPSB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPSB4 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Spsb41 , 5 splA/ryanodine receptor domain and SOCS box containing more1, 5 88.03(n)1
    97.8(a)1    		   9 (50.74 cM)5
    2119491  NM_145134.31  NP_660116.11 
     969434825 
    chicken
    (Gallus gallus)    		 Aves SPSB41 splA/ryanodine receptor domain and SOCS box containing more 71.31(n)
    81.32(a)    		   429129  XM_426685.2  XP_426685.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SPSB46
    		 splA/ryanodine receptor domain and SOCS box contai...
    		 82(a)
    		 1 ↔ 1
    		 GL343404.1(631397-710596)
    zebrafish
    (Danio rerio)    		 Actinopterygii nszf-e3262 nszf-e326 73.91(n)   335778  CF996573.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta gus1 gustavus 58.21(n)
    69.49(a)    		   35478  NM_136314.3  NP_610158.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea spsb-11 Protein SPSB-1 57.83(n)
    58.5(a)    		   266876  NM_064920.3  NP_497321.3 


    ENSEMBL Gene Tree for SPSB4 (if available)
    TreeFam Gene Tree for SPSB4 (if available)

    Paralogs
    for SPSB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPSB4 gene
    SPSB22  FBXO452  SPSB12  
    18/36 SIMAP similar genes for SPSB4 using alignment to 2 protein entries:     SPSB4_HUMAN (see all proteins) (see all similar genes):
    COX7A2    IPO7    ZNF568    ZNF83    SPSB1    ZNF738
    TMEM67    CES4A    THADA    IFT122    TGFBR3    C12orf23
    DAPK2    NDUFS7    NSD1    SENP7    ZNF23    ZNHIT3

    SPSB4 for paralogs           About GeneDecksing



    Genomic Variants
    for SPSB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1882 SNPs in SPSB4 are shown (see all 1882)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1917204651,2
    		--138143615(+) CAGGGC/TATCCA 1 -- int10--------
    rs1846364481,2
    		--138143730(+) AATACG/TTGTCA 1 -- int10--------
    rs1123980781,2
    		C,F--138143738(+) TCAATG/ACACAC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1488092831,2
    		--138143863(+) GGTCTC/TTCTGG 1 -- int10--------
    rs1424577101,2
    		--138143891(+) GTCACC/TACCCT 1 -- int10--------
    rs1889585361,2
    		--138143895(+) CTACCC/TTGGTT 1 -- int10--------
    rs1513148381,2
    		--138143968(+) GACACC/GGTCCA 1 -- int10--------
    rs1393668081,2
    		--138143987(+) GTTCCC/GTCATA 1 -- int10--------
    rs1932686351,2
    		C--138143996(+) TACCCA/CCTCTG 1 -- int10--------
    rs1500283281,2
    		--138144145(+) CCAGAA/GCCTCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPSB4 (140770244 - 140867453 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPSB4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv22188CNV Loss19812545
    nsv877550CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPSB4
    DNA2.0 Custom Variant and Variant Library Synthesis for SPSB4

    Disorders / Diseases
    for SPSB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 611660    OMIM disorders: --

    2 diseases for SPSB4:    About MalaCards
    brucellosis    


    SPSB4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPSB4
    Human Genome Epidemiology (HuGE) Navigator: SPSB4 (1 document)

    Export disorders for SPSB4 gene to outside databases

    Publications
    for SPSB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPSB4 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SPSB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2, 9 Wang D....Wu G. (2005)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (2004)
    6. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
    7. Genetic risk factors for ischaemic stroke and its subt ypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. (PubMed id 23041239)1 Traylor M....Markus H.S. (2012)
    8. Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PubMed id 21199876)1 Nishiya T....Miwa S. (2011)
    9. The SPRY domain-containing SOCS box protein SPSB2 tar gets iNOS for proteasomal degradation. (PubMed id 20603330)1 Kuang Z....Nicholson S.E. (2010)
    10. Structural basis for Par-4 recognition by the SPRY do main- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. (PubMed id 20561531)1 Filippakopoulos P....Bullock A.N. (2010)

    External Searches for SPSB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPSB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92369 HGNC: 30630 AceView: SSB4 Ensembl:ENSG00000175093 euGenes: HUgn92369
    ECgene: SPSB4 H-InvDB: SPSB4

    Other Databases showing SPSB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPSB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPSB4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPSB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPSB4 gene:
    Search GeneIP for patents involving SPSB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SPSB4 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPSB4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for SPSB4   OriGene clones in human, mouse for SPSB4  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4   OriGene Purified Protein for SPSB4  
     OriGene ORF clones in mouse, rat for SPSB4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPSB4   OriGene Custom Protein Services for SPSB4  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPSB4
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPSB4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPSB4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPSB4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPSB4
     GenScript Custom Purified and Recombinant Proteins Services for SPSB4 GenScript cDNA clones with any tag delivered in your preferred vector for SPSB4
     GenScript Custom Assay Services for SPSB4 GenScript Custom Superior Antibodies Services for SPSB4
     GenScript Custom overexpressing Cell Line Services for SPSB4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SPSB4 promoter
     Search Chromatin IP Primers for SPSB4
     RT2 qPCR Primer Assay in human, mouse, rat SPSB4
     Search GNC Networks for SPSB4
     SABiosciences PCR Arrays including human, mouse, rat SPSB4
     Search Tocris compounds for SPSB4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPSB4 proteins
     Search for Antibodies for SPSB4 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SPSB4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SPSB4
     Antibodies for SPSB4
     ELISAs for SPSB4
     CLIAs for SPSB4
     Search LifeMap BioReagents cell lines for SPSB4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4
     SwitchGear 3'UTR luciferase reporter plasmids for SPSB4
     SwitchGear Promoter luciferase reporter plasmids for SPSB4
     Search ThermoFisher Antibodies for SPSB4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPSB4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPSB4
    Customized:
     lentivirus for stable overexpression of SPSB4
     lentivirus expression plasmids for stable overexpression of SPSB4
     adenovirus for overexpression of SPSB4
     Search LSBio for Antibodies for SPSB4
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SPSB4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4