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Aliases for SPSB4 Gene

Aliases for SPSB4 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 4 2 3
  • SSB4 3 4 6
  • SSB-4 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-4 3
  • SPRY Domain-Containing SOCS Box Protein 4 3

External Ids for SPSB4 Gene

Summaries for SPSB4 Gene

GeneCards Summary for SPSB4 Gene

SPSB4 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot for SPSB4 Gene

  • Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB4 Gene

Genomics for SPSB4 Gene

Genomic Location for SPSB4 Gene

Start:
141,051,402 bp from pter
End:
141,148,611 bp from pter
Size:
97,210 bases
Orientation:
Plus strand

Genomic View for SPSB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPSB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB4 Gene

Regulatory Elements for SPSB4 Gene

Proteins for SPSB4 Gene

  • Protein details for SPSB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A44-SPSB4_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 4
    Protein Accession:
    Q96A44
    Secondary Accessions:

    Protein attributes for SPSB4 Gene

    Size:
    273 amino acids
    Molecular mass:
    30179 Da
    Quaternary structure:
    • Interacts with PARW (By similarity). Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for SPSB4 Gene

neXtProt entry for SPSB4 Gene

Proteomics data for SPSB4 Gene at MOPED

Post-translational modifications for SPSB4 Gene

No Post-translational modifications

Other Protein References for SPSB4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SPSB4 Gene

Domains for SPSB4 Gene

Protein Domains for SPSB4 Gene

UniProtKB/Swiss-Prot:

SPSB4_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.:
    • Q96A44
  • Contains 1 B30.2/SPRY domain.:
    • Q96A44
  • Contains 1 SOCS box domain.:
    • Q96A44
Family:
  • Belongs to the SPSB family.:
    • Q96A44
genes like me logo Genes that share domains with SPSB4: view

No data available for Gene Families for SPSB4 Gene

Function for SPSB4 Gene

Molecular function for SPSB4 Gene

UniProtKB/Swiss-Prot Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for SPSB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15601820
genes like me logo Genes that share ontologies with SPSB4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPSB4 Gene

Localization for SPSB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPSB4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPSB4 Gene COMPARTMENTS Subcellular localization image for SPSB4 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPSB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPSB4: view

Pathways for SPSB4 Gene

genes like me logo Genes that share pathways with SPSB4: view

UniProtKB/Swiss-Prot Q96A44-SPSB4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SPSB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SPSB4: view

Transcripts for SPSB4 Gene

Unigene Clusters for SPSB4 Gene

SplA/ryanodine receptor domain and SOCS box containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:

Relevant External Links for SPSB4 Gene

GeneLoc Exon Structure for
SPSB4
ECgene alternative splicing isoforms for
SPSB4

Expression for SPSB4 Gene

mRNA expression in normal human tissues for SPSB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPSB4 Gene

This gene is overexpressed in Pancreas (11.5), Testis (6.7), and Pituitary (6.5).

SOURCE GeneReport for Unigene cluster for SPSB4 Gene Hs.655112

genes like me logo Genes that share expressions with SPSB4: view

Orthologs for SPSB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPSB4 36
  • 99.63 (n)
  • 100 (a)
SPSB4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPSB4 36
  • 92.31 (n)
  • 97.44 (a)
SPSB4 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPSB4 36
  • 93.41 (n)
  • 96.7 (a)
SPSB4 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spsb4 36
  • 88.03 (n)
  • 97.8 (a)
Spsb4 16
Spsb4 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPSB4 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPSB4 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spsb4 36
  • 86.94 (n)
  • 97.8 (a)
chicken
(Gallus gallus)
Aves SPSB4 36
  • 71.31 (n)
  • 81.32 (a)
SPSB4 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPSB4 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spsb4 36
  • 69.35 (n)
  • 80.59 (a)
zebrafish
(Danio rerio)
Actinopterygii nszf-e326 36
spsb4a 36
  • 73.02 (n)
  • 79.12 (a)
spsb4a 37
  • 78 (a)
OneToMany
spsb4b 37
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010197 36
  • 65.2 (n)
  • 68.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta gus 36
  • 58.21 (n)
  • 69.49 (a)
gus 37
  • 67 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spsb-1 36
  • 57.83 (n)
  • 58.5 (a)
spsb-1 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8004 37
  • 51 (a)
OneToMany
Species with no ortholog for SPSB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPSB4 Gene

ENSEMBL:
Gene Tree for SPSB4 (if available)
TreeFam:
Gene Tree for SPSB4 (if available)

Paralogs for SPSB4 Gene

Paralogs for SPSB4 Gene

genes like me logo Genes that share paralogs with SPSB4: view

Variants for SPSB4 Gene

Sequence variations from dbSNP and Humsavar for SPSB4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs875870 -- 141,149,096(+) ACTGG(A/G)ATAGC downstream-variant-500B
rs890527 -- 141,056,011(+) TGGAG(A/T)GAGAG intron-variant
rs890528 -- 141,059,921(+) TAAGT(C/T)CTGGC intron-variant
rs890529 -- 141,066,333(-) GTGCC(G/T)GTGGA synonymous-codon, reference
rs899348 -- 141,109,959(-) CTCTG(C/T)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPSB4 Gene

Variant ID Type Subtype PubMed ID
esv22188 CNV Loss 19812545
nsv877550 CNV Gain 21882294

Relevant External Links for SPSB4 Gene

HapMap Linkage Disequilibrium report
SPSB4

Disorders for SPSB4 Gene

Relevant External Links for SPSB4

Genetic Association Database (GAD)
SPSB4
Human Genome Epidemiology (HuGE) Navigator
SPSB4
genes like me logo Genes that share disorders with SPSB4: view

No data available for UniProtKB/Swiss-Prot for SPSB4 Gene

Publications for SPSB4 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 3 4 23
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PMID: 15601820) Kamura T. … Nakayama K.I. (Genes Dev. 2004) 3 4

Products for SPSB4 Gene

Sources for SPSB4 Gene

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