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Aliases for SPSB4 Gene

Aliases for SPSB4 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 4 2 3 5
  • SSB-4 3 4
  • SSB4 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-4 3
  • SPRY Domain-Containing SOCS Box Protein 4 3

External Ids for SPSB4 Gene

Previous GeneCards Identifiers for SPSB4 Gene

  • GC03P142253
  • GC03P140770
  • GC03P138145

Summaries for SPSB4 Gene

GeneCards Summary for SPSB4 Gene

SPSB4 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SPSB1.

UniProtKB/Swiss-Prot for SPSB4 Gene

  • Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB4 Gene

Genomics for SPSB4 Gene

Regulatory Elements for SPSB4 Gene

Enhancers for SPSB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F141078 0.4 ENCODE 12.6 +27.6 27560 0.1 SPSB4 LOC105374133
GH03F141070 0.4 ENCODE 12.2 +20.4 20434 1.8 NFIA TEAD4 MAX CEBPB CEBPG ZIC2 BCL11A POLR2A CTBP2 KDM1A SPSB4 LOC105374133
GH03F141073 0.6 ENCODE 12.2 +25.0 25035 4.6 KLF1 PKNOX1 KLF17 ZIC2 ZFHX2 POLR2A ZNF600 TCF7L2 EGR2 MAZ SPSB4 LOC105374133
GH03F141011 0.8 Ensembl ENCODE 12.1 -37.8 -37795 2.5 CTCF TRIM22 TBX21 ZBTB7A RAD21 RELA ZFHX2 SMARCA4 KLF16 POLR2A SPSB4 ENSG00000248773
GH03F141012 0.2 ENCODE 12.1 -39.1 -39102 0.2 CTCF ZNF654 TRIM22 REST ZBTB7A RAD21 RELA ZNF316 ZFHX2 SMARCA4 SPSB4 ENSG00000248773
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPSB4 on UCSC Golden Path with GeneCards custom track

Promoters for SPSB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001375283 1205 2401 ZNF76 KLF17 ZNF2 RAD21 FOS REST ZEB2 ZNF623 SMARCA4 ZNF341

Genomic Location for SPSB4 Gene

Chromosome:
3
Start:
141,050,795 bp from pter
End:
141,148,611 bp from pter
Size:
97,817 bases
Orientation:
Plus strand

Genomic View for SPSB4 Gene

Genes around SPSB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPSB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPSB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB4 Gene

Proteins for SPSB4 Gene

  • Protein details for SPSB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A44-SPSB4_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 4
    Protein Accession:
    Q96A44

    Protein attributes for SPSB4 Gene

    Size:
    273 amino acids
    Molecular mass:
    30179 Da
    Quaternary structure:
    • Interacts with PARW (By similarity). Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for SPSB4 Gene

neXtProt entry for SPSB4 Gene

Post-translational modifications for SPSB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPSB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPSB4 Gene

Domains & Families for SPSB4 Gene

Protein Domains for SPSB4 Gene

Suggested Antigen Peptide Sequences for SPSB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A44

UniProtKB/Swiss-Prot:

SPSB4_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the SPSB family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the SPSB family.
genes like me logo Genes that share domains with SPSB4: view

No data available for Gene Families for SPSB4 Gene

Function for SPSB4 Gene

Molecular function for SPSB4 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for SPSB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15601820
genes like me logo Genes that share ontologies with SPSB4: view
genes like me logo Genes that share phenotypes with SPSB4: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPSB4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPSB4 Gene

Localization for SPSB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPSB4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPSB4 Gene COMPARTMENTS Subcellular localization image for SPSB4 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPSB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPSB4: view

Pathways & Interactions for SPSB4 Gene

genes like me logo Genes that share pathways with SPSB4: view

UniProtKB/Swiss-Prot Q96A44-SPSB4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPSB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SPSB4: view

No data available for SIGNOR curated interactions for SPSB4 Gene

Transcripts for SPSB4 Gene

Unigene Clusters for SPSB4 Gene

SplA/ryanodine receptor domain and SOCS box containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPSB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:

Relevant External Links for SPSB4 Gene

GeneLoc Exon Structure for
SPSB4
ECgene alternative splicing isoforms for
SPSB4

Expression for SPSB4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPSB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPSB4 Gene

This gene is overexpressed in Pancreas (x11.5), Testis (x6.7), and Pituitary (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of SPSB4 Gene:

SPSB4

SOURCE GeneReport for Unigene cluster for SPSB4 Gene:

Hs.655112
genes like me logo Genes that share expression patterns with SPSB4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPSB4 Gene

Orthologs for SPSB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPSB4 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia SPSB4 34 35
  • 93.41 (n)
cow
(Bos Taurus)
Mammalia SPSB4 34 35
  • 92.31 (n)
mouse
(Mus musculus)
Mammalia Spsb4 34 16 35
  • 88.03 (n)
rat
(Rattus norvegicus)
Mammalia Spsb4 34
  • 86.94 (n)
oppossum
(Monodelphis domestica)
Mammalia SPSB4 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPSB4 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPSB4 34 35
  • 71.31 (n)
lizard
(Anolis carolinensis)
Reptilia SPSB4 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spsb4 34
  • 69.35 (n)
zebrafish
(Danio rerio)
Actinopterygii spsb4a 34 35
  • 73.02 (n)
spsb4b 35
  • 67 (a)
OneToMany
nszf-e326 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010197 34
  • 65.2 (n)
fruit fly
(Drosophila melanogaster)
Insecta gus 34 35
  • 58.21 (n)
worm
(Caenorhabditis elegans)
Secernentea spsb-1 34 35
  • 57.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8004 35
  • 51 (a)
OneToMany
Species where no ortholog for SPSB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPSB4 Gene

ENSEMBL:
Gene Tree for SPSB4 (if available)
TreeFam:
Gene Tree for SPSB4 (if available)

Paralogs for SPSB4 Gene

Paralogs for SPSB4 Gene

genes like me logo Genes that share paralogs with SPSB4: view

Variants for SPSB4 Gene

Sequence variations from dbSNP and Humsavar for SPSB4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1007118 -- 141,126,743(+) AGTTT(A/G/T)CTAGG intron-variant
rs10439962 -- 141,057,439(+) GCATT(C/T)CCAGT intron-variant
rs10533999 -- 141,082,928(+) CTTTC(-/TTTG)TTTGG intron-variant, utr-variant-3-prime
rs10573879 -- 141,076,088(+) AAAAT(-/AAAAT)GCGTA intron-variant
rs10716790 -- 141,097,279(+) TCTTA(-/C)CTAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPSB4 Gene

Variant ID Type Subtype PubMed ID
esv22188 CNV loss 19812545
esv3562633 CNV deletion 23714750
esv3597970 CNV loss 21293372
nsv591889 CNV loss 21841781
nsv591890 CNV loss 21841781
nsv955357 CNV deletion 24416366

Variation tolerance for SPSB4 Gene

Gene Damage Index Score: 1.61; 30.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPSB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPSB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB4 Gene

Disorders for SPSB4 Gene

Relevant External Links for SPSB4

Genetic Association Database (GAD)
SPSB4
Human Genome Epidemiology (HuGE) Navigator
SPSB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPSB4

No disorders were found for SPSB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB4 Gene

Publications for SPSB4 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PMID: 15601820) Kamura T. … Nakayama K.I. (Genes Dev. 2004) 3 4 64

Products for SPSB4 Gene

Sources for SPSB4 Gene

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