Aliases for SPSB4 Gene
Aliases for SPSB4 Gene
External Ids for SPSB4 Gene
- HGNC: 30630
- Entrez Gene: 92369
- Ensembl: ENSG00000175093
- OMIM: 611660
- UniProtKB: Q96A44
Previous GeneCards Identifiers for SPSB4 Gene
- GC03P142253
- GC03P140770
- GC03P138145
Summaries for SPSB4 Gene
GeneCards Summary for SPSB4 Gene
SPSB4 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SPSB1.
UniProtKB/Swiss-Prot for SPSB4 Gene
-
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB4 Gene
Genomics for SPSB4 Gene
Regulatory Elements for SPSB4 Gene
Enhancers for SPSB4 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH03F141192 | 1.2 | Ensembl ENCODE | 10.9 | +141.6 | 141580 | 0.3 | ELF3 WRNIP1 ZNF48 ZNF2 RAD21 RFX5 YY1 ZNF335 GLIS2 ZNF366 | PXYLP1 SPSB4 PIR61633 LOC105374133 |
| GH03F141011 | 1 | Ensembl ENCODE | 12.1 | -37.8 | -37795 | 2.5 | CTCF TRIM22 TBX21 ZBTB7A RAD21 RELA ZFHX2 SMARCA4 KLF16 POLR2A | SPSB4 ENSG00000248773 |
| GH03F141113 | 0.9 | Ensembl ENCODE | 11.7 | +64.8 | 64767 | 3.8 | CTCF ZNF133 ZNF140 USF2 ZNF316 RAD51 GATA3 ZNF692 CEBPA FOS | SPSB4 LOC105374133 |
| GH03F141073 | 0.8 | ENCODE | 12.2 | +25.0 | 25035 | 4.6 | KLF1 PKNOX1 KLF17 ZIC2 ZFHX2 POLR2A ZNF600 TCF7L2 EGR2 MAZ | SPSB4 LOC105374133 |
| GH03F141082 | 0.8 | Ensembl ENCODE | 11.7 | +33.5 | 33525 | 3.1 | PKNOX1 SMARCA4 POLR2A ZMYM3 KDM1A | SPSB4 LOC105374133 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SPSB4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SPSB4 gene promoter:
Regulatory Element Products
Genomic Location for SPSB4 Gene
- Chromosome:
- 3
- Start:
- 141,050,795 bp from pter
- End:
- 141,148,611 bp from pter
- Size:
- 97,817 bases
- Orientation:
- Plus strand
Genomic View for SPSB4 Gene
Genes around SPSB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3q23 by Ensembl
- 3q23 by Entrez Gene
- 3q23 by HGNC
SPSB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPSB4 Gene
Proteins for SPSB4 Gene
-
Protein details for SPSB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96A44-SPSB4_HUMAN
- Recommended name:
- SPRY domain-containing SOCS box protein 4
- Protein Accession:
- Q96A44
Protein attributes for SPSB4 Gene
- Size:
- 273 amino acids
- Molecular mass:
- 30179 Da
- Quaternary structure:
-
- Interacts with PARW (By similarity). Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4. Interacts with MET.
Post-translational modifications for SPSB4 Gene
Other Protein References for SPSB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for SPSB4
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPSB4
Protein Products
-
OriGene Purified Proteins for SPSB4
- Search Origene for MassSpec and Protein Over-expression Lysates for SPSB4
- Origene Custom Protein Services for SPSB4
- Novus Biologicals proteins for SPSB4
- antibodies-online Proteins for SPSB4: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SPSB4
-
Abcam proteins for SPSB4
Assay Products
No data available for DME Specific Peptides for SPSB4 Gene
Domains & Families for SPSB4 Gene
Protein Domains for SPSB4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPSB4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96A44UniProtKB/Swiss-Prot:
SPSB4_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
- Belongs to the SPSB family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
- Contains 1 B30.2/SPRY domain.
- Contains 1 SOCS box domain.
- Family:
-
- Belongs to the SPSB family.
No data available for Gene Families for SPSB4 Gene
Function for SPSB4 Gene
Molecular function for SPSB4 Gene
- UniProtKB/Swiss-Prot Function:
- Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 15601820 |
Phenotypes for SPSB4 Gene
- GenomeRNAi human phenotypes for SPSB4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPSB4
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPSB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPSB4 gene
- Search ViGene Biosciences for SPSB4
CRISPR Products
-
OriGene CRISPR knockouts for SPSB4
- GenScript: Design CRISPR guide RNA sequences for SPSB4
miRNA for SPSB4 Gene
- miRTarBase miRNAs that target SPSB4
miRNA Products
- Search ViGene Biosciences for SPSB4
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SPSB4
- VectorBuilder custom plasmid, inducible vectors for SPSB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPSB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SPSB4
-
ViGene Biosciences adenoviral particle packaged cDNA for SPSB4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPSB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPSB4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPSB4 Gene
Localization for SPSB4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPSB4 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
Pathways & Interactions for SPSB4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Class I MHC mediated antigen processing and presentation | ||
| 2 | Immune System |
.61
|
|
Pathways by source for SPSB4 Gene
4 Reactome pathways for SPSB4 Gene
UniProtKB/Swiss-Prot Q96A44-SPSB4_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SPSB4 Gene
Selected Interacting proteins:
ENSP00000311609
Q96A44-SPSB4_HUMAN
for SPSB4 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0035556 | intracellular signal transduction | IEA | -- |
No data available for SIGNOR curated interactions for SPSB4 Gene
Transcripts for SPSB4 Gene
mRNA/cDNA for SPSB4 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPSB4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPSB4
- GenScript: Design CRISPR guide RNA sequences for SPSB4
miRNA Products
- Search ViGene Biosciences for SPSB4
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SPSB4
- VectorBuilder custom plasmid, inducible vectors for SPSB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPSB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||
| SP2: | - | - | - | ||||||||||
| SP3: |
Expression for SPSB4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
mRNA differential expression in normal tissues according to GTEx for SPSB4 Gene
This gene is overexpressed in Pancreas (x11.5), Testis (x6.7), and Pituitary (x6.5).
NURSA nuclear receptor signaling pathways regulating expression of SPSB4 Gene:
SPSB4SOURCE GeneReport for Unigene cluster for SPSB4 Gene:
Hs.655112Primer Products
-
OriGene qPCR primer pairs for SPSB4
-
OriGene qPCR primer pairs and template standards for SPSB4
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPSB4 Gene
Orthologs for SPSB4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPSB4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SPSB4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SPSB4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Spsb4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Spsb4 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | SPSB4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | SPSB4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | SPSB4 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | SPSB4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | spsb4 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | spsb4a 34 35 |
|
||
| spsb4b 35 |
|
OneToMany | |||
| nszf-e326 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010197 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | gus 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | spsb-1 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8004 35 |
|
OneToMany |
- Species where no ortholog for SPSB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SPSB4 Gene
(37) SIMAP similar genes for SPSB4 Gene using alignment to 2 proteins:
Variants for SPSB4 Gene
| SNP ID | Clin | Chr 03 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1007118 | -- | 141,126,743(+) | AGTTT(A/G/T)CTAGG | intron-variant | |
| rs10439962 | -- | 141,057,439(+) | GCATT(C/T)CCAGT | intron-variant | |
| rs10533999 | -- | 141,082,928(+) | CTTTC(-/TTTG)TTTGG | intron-variant, utr-variant-3-prime | |
| rs10573879 | -- | 141,076,088(+) | AAAAT(-/AAAAT)GCGTA | intron-variant | |
| rs10716790 | -- | 141,097,279(+) | TCTTA(-/C)CTAGA | intron-variant |
Gene Damage Index Score:
1.61;
30.91% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SPSB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPSB4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB4 Gene
Disorders for SPSB4 Gene
Relevant External Links for SPSB4
No disorders were found for SPSB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB4 Gene
Publications for SPSB4 Gene
- The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 3 4 22 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PMID: 15601820) Kamura T. … Nakayama K.I. (Genes Dev. 2004) 3 4 64
Products for SPSB4 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for SPSB4
- Search Origene for MassSpec and Protein Over-expression Lysates for SPSB4
- Origene Custom Protein Services for SPSB4
- Origene mouse_rna, siRNA, rat_shrna, shRNA, and RNAi products in human, mouse, rat for SPSB4
- Browse OriGene Inhibitory RNA Products For SPSB4
- OriGene qPCR primer pairs for SPSB4
- OriGene qPCR primer pairs and template standards for SPSB4
- OriGene CRISPR knockouts for SPSB4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA clones in your preferred vector
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- GenScript: Design CRISPR guide RNA sequences for SPSB4
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- CloneReady with Over 120,000 Genes
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- Sino Biological Transfection Reagents
- Novus Biologicals proteins for SPSB4
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for SPSB4
- Search GeneTex for Antibodies for SPSB4
- Search GeneTex for Proteins for SPSB4
- ViGene Biosciences adenoviral particle packaged cDNA for SPSB4 gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPSB4 gene
- ViGene Biosciences ready-to-package AAV shRNAs for SPSB4 gene
- Search ViGene Biosciences for SPSB4
- Santa Cruz Biotechnology (SCBT) Antibodies for SPSB4
- Search Santa Cruz Biotechnology (SCBT) for SPSB4 siRNA/shRNA
- Browse Santa Cruz Biotechnology (SCBT) for SPSB4 CRISPR
- Horizon Cell Lines for SPSB4
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPSB4
- VectorBuilder custom plasmid, inducible vectors for SPSB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPSB4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SPSB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
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- (150) St John's Lab