Aliases for SPSB4 Gene
Aliases for SPSB4 Gene
External Ids for SPSB4 Gene
- HGNC: 30630
- Entrez Gene: 92369
- Ensembl: ENSG00000175093
- OMIM: 611660
- UniProtKB: Q96A44
Previous GeneCards Identifiers for SPSB4 Gene
- GC03P142253
- GC03P140770
- GC03P138145
Summaries for SPSB4 Gene
GeneCards Summary for SPSB4 Gene
SPSB4 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SPSB1.
UniProtKB/Swiss-Prot for SPSB4 Gene
-
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Additional gene information for SPSB4 Gene
- Monarch Initiative
- Search for SPSB4 at DataMed
- Search for SPSB4 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB4 Gene
Genomics for SPSB4 Gene
GeneHancer (GH) Regulatory Elements for SPSB4 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH03I141050 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 550.8 | +1.2 | 1206 | 2.6 | KLF17 ZNF76 ZNF2 ZNF335 GLIS2 ZNF398 REST ZEB2 ZNF341 ZBTB26 | SPSB4 ENSG00000251270 | |
GH03I141073 | Promoter/Enhancer | 1.5 | Ensembl ENCODE dbSUPER | 12.2 | +25.0 | 25034 | 4.6 | KLF1 LEF1 PKNOX1 ZBTB21 KLF17 ZIC2 ZFHX2 POLR2A ZNF600 TCF7L2 | SPSB4 ENSG00000251270 | |
GH03I141113 | Enhancer | 0.9 | Ensembl ENCODE dbSUPER | 11.7 | +64.8 | 64767 | 3.8 | MITF CTCF RAD51 USF1 ZNF143 USF2 CBFA2T2 | SPSB4 ENSG00000251270 | |
GH03I141192 | Enhancer | 0.9 | ENCODE | 10.9 | +141.6 | 141649 | 0.2 | SIN3A ZNF2 ZNF48 YY1 GLIS2 ZNF213 ARID2 ZNF143 ATF7 RUNX3 | PXYLP1 SPSB4 PIR61633 ENSG00000251270 | |
GH03I141012 | Enhancer | 0.8 | Ensembl ENCODE | 12.1 | -37.8 | -37795 | 2.5 | CTCF PKNOX1 TRIM22 RAD21 RELA ZFHX2 KLF16 POLR2A SMC3 ZNF143 | SPSB4 ENSG00000248773 |
Regulatory Element Products
Genomic Locations for SPSB4 Gene
- chr3:141,050,795-141,148,611
- (GRCh38/hg38)
- Size:
- 97,817 bases
- Orientation:
- Plus strand
- chr3:140,770,244-140,867,453
- (GRCh37/hg19)
Genomic View for SPSB4 Gene
- Cytogenetic band:
-
- 3q23 by Ensembl
- 3q23 by Entrez Gene
- 3q23 by HGNC


RefSeq DNA sequence for SPSB4 Gene
Proteins for SPSB4 Gene
-
Protein details for SPSB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96A44-SPSB4_HUMAN
- Recommended name:
- SPRY domain-containing SOCS box protein 4
- Protein Accession:
- Q96A44
Protein attributes for SPSB4 Gene
- Size:
- 273 amino acids
- Molecular mass:
- 30179 Da
- Quaternary structure:
-
- Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4 (PubMed:15601820). Interacts with CUL5; RNF7; ELOB and ELOC (PubMed:15601820). Interacts with MET (PubMed:15713673). Interacts (via B30.2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex (PubMed:20561531).
Post-translational modifications for SPSB4 Gene
Other Protein References for SPSB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for SPSB4
- Invitrogen Antibodies for SPSB4
- Search GeneTex for Antibodies for SPSB4
-
Santa Cruz Biotechnology (SCBT) Antibodies for SPSB4
Protein Products
-
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- antibodies-online: Search results for 4 available SPSB4 Proteins ranked by validation data
- Compare Top SPSB4 Proteins
-
Quality Products:
- Search GeneTex for Proteins for SPSB4
Assay Products
No data available for DME Specific Peptides for SPSB4 Gene
Domains & Families for SPSB4 Gene
Gene Families for SPSB4 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SPSB4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPSB4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96A44UniProtKB/Swiss-Prot:
SPSB4_HUMAN :- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
- Belongs to the SPSB family.
- Domain:
-
- The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
- Family:
-
- Belongs to the SPSB family.
Function for SPSB4 Gene
Molecular function for SPSB4 Gene
- UniProtKB/Swiss-Prot Function:
- Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Phenotypes From GWAS Catalog for SPSB4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 15601820 |
Phenotypes for SPSB4 Gene
- GenomeRNAi human phenotypes for SPSB4:
Animal Model Products
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-
-
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-
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- Search ViGene Biosciences for SPSB4
CRISPR Products
-
OriGene CRISPR knockouts for SPSB4
- genomics-online: gRNA clones - Search results for 86 available SPSB4 gene related products
- Overview of 86 available SPSB4 gene related products
- Applied Biological Materials CRISPR for SPSB4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPSB4
- GenScript: Design CRISPR guide RNA sequences for SPSB4
miRNA for SPSB4 Gene
- miRTarBase miRNAs that target SPSB4
miRNA Products
- Search ViGene Biosciences for SPSB4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPSB4
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- Overview of 86 available SPSB4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPSB4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPSB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPSB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SPSB4
- Applied Biological Materials Clones for SPSB4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPSB4
-
ViGene Biosciences adenoviral particle packaged cDNA for SPSB4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPSB4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SPSB4 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPSB4 Gene
Localization for SPSB4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPSB4 Gene
- Cytoplasm.
- Golgi apparatus (2)
- Nucleoplasm (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for SPSB4 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Class I MHC mediated antigen processing and presentation | ||
2 | Innate Immune System |
.61
|
Pathways by source for SPSB4 Gene
4 Reactome pathways for SPSB4 Gene
UniProtKB/Swiss-Prot Q96A44-SPSB4_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for SPSB4 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0035556 | intracellular signal transduction | IEA | -- |
GO:0043687 | post-translational protein modification | TAS | -- |
No data available for SIGNOR curated interactions for SPSB4 Gene
Transcripts for SPSB4 Gene
mRNA/cDNA for SPSB4 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (46) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPSB4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPSB4
- genomics-online: gRNA clones - Search results for 86 available SPSB4 gene related products
- Overview of 86 available SPSB4 gene related products
- Applied Biological Materials CRISPR for SPSB4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPSB4
- GenScript: Design CRISPR guide RNA sequences for SPSB4
miRNA Products
- Search ViGene Biosciences for SPSB4
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for SPSB4
- Browse OriGene Inhibitory RNA Products For SPSB4
- genomics-online: shRNA clones - Search results for 86 available SPSB4 gene related products
- Overview of 86 available SPSB4 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for SPSB4 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPSB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPSB4
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SPSB4
- Applied Biological Materials Clones for SPSB4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||
SP2: | - | - | - | ||||||||||
SP3: |
Expression for SPSB4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- nGnG Amacrine Cells Inner Nuclear Layer
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Mesoderm (Gastrulation Derivatives)
- Mesothelial Cells Hepatic Mesenchyme
-
Liver (Hepatobiliary System)
- Mesothelial Cells Hepatic Mesenchyme
-
Neural Tube (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
-
Brain (Nervous System)
- Adult Oligodendrocyte Precursor Cells Cortical Sub Ventricular Zone
mRNA differential expression in normal tissues according to GTEx for SPSB4 Gene
NURSA nuclear receptor signaling pathways regulating expression of SPSB4 Gene:
SPSB4SOURCE GeneReport for Unigene cluster for SPSB4 Gene:
Hs.655112Evidence on tissue expression from TISSUES for SPSB4 Gene
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for SPSB4
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPSB4 Gene
Orthologs for SPSB4 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | SPSB4 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | SPSB4 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | SPSB4 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Spsb4 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Spsb4 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | SPSB4 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | SPSB4 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | SPSB4 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | SPSB4 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | spsb4 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | spsb4a 33 34 |
|
||
spsb4b 34 |
|
OneToMany | |||
nszf-e326 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010197 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | gus 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | spsb-1 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8004 34 |
|
OneToMany |
- Species where no ortholog for SPSB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for SPSB4 Gene
(37) SIMAP similar genes for SPSB4 Gene using alignment to 2 proteins:
Variants for SPSB4 Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000016357 | -- | 141,076,476(+) | G/ | intron_variant | |
rs1000062328 | -- | 141,142,517(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
rs1000063032 | -- | 141,100,691(+) | G/T | genic_downstream_transcript_variant, intron_variant | |
rs1000104284 | -- | 141,129,121(+) | C/A | genic_downstream_transcript_variant, intron_variant | |
rs1000118042 | -- | 141,067,279(+) | C/T | intron_variant |
Additional Variant Information for SPSB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPSB4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB4 Gene
Disorders for SPSB4 Gene
Additional Disease Information for SPSB4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for SPSB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB4 Gene
Publications for SPSB4 Gene
- The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D … Wu G (The Journal of biological chemistry 2005) 3 4 22 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. (PMID: 20561531) Filippakopoulos P … Bullock AN (Journal of molecular biology 2010) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for SPSB4 Gene
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- Invitrogen Antibodies for SPSB4
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPSB4
- VectorBuilder custom plasmid, inducible vectors for SPSB4
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPSB4
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for SPSB4
- antibodies-online: Search results for available SPSB4 related products ranked by validation data
- antibodies-online: Search results for available SPSB4 related products ranked by validation data
- antibodies-online: Search results for 4 available SPSB4 Proteins ranked by validation data
- Compare Top SPSB4 Proteins
- Quality Products:
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- genomics-online: cdna clones - Search results for 86 available SPSB4 gene related products
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- Overview of 86 available SPSB4 gene related products
- genomics-online: shRNA clones - Search results for 86 available SPSB4 gene related products
- Overview of 86 available SPSB4 gene related products
Sources for SPSB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
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