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SPSB4 Gene(Protein Coding)

SplA/Ryanodine Receptor Domain And SOCS Box Containing 4

GCID:
GC03P141051
GIFtS:
45
Genes Participants
UDN Logo

Aliases for SPSB4 Gene

Aliases for SPSB4 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 4 2 3 5
  • SSB-4 3 4
  • SSB4 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-4 3

External Ids for SPSB4 Gene

Previous GeneCards Identifiers for SPSB4 Gene

  • GC03P142253
  • GC03P140770
  • GC03P138145

Summaries for SPSB4 Gene

GeneCards Summary for SPSB4 Gene

SPSB4 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 4) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot for SPSB4 Gene

  • Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB4 Gene

Genomics for SPSB4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for SPSB4 Gene

Enhancers for SPSB4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPSB4 on UCSC Golden Path with GeneCards custom track

Promoters for SPSB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPSB4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SPSB4 gene promoter:

Genomic Location for SPSB4 Gene

Chromosome:
3
Start:
141,050,795 bp from pter
End:
141,148,611 bp from pter
Size:
97,817 bases
Orientation:
Plus strand

Genomic View for SPSB4 Gene

Genes around SPSB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPSB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPSB4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for SPSB4 Gene

Proteins for SPSB4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for SPSB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A44-SPSB4_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 4
    Protein Accession:
    Q96A44

    Protein attributes for SPSB4 Gene

    Size:
    273 amino acids
    Molecular mass:
    30179 Da
    Quaternary structure:
    • Interacts with PARW (By similarity). Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4. Interacts with MET.

    Three dimensional structures from OCA and Proteopedia for SPSB4 Gene

neXtProt entry for SPSB4 Gene

Proteomics data for SPSB4 Gene at MOPED

Post-translational modifications for SPSB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPSB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPSB4 Gene

Domains & Families for SPSB4 Gene

Protein Domains for SPSB4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPSB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A44

UniProtKB/Swiss-Prot:

SPSB4_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the SPSB family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the SPSB family.
genes like me logo Genes that share domains with SPSB4: view

No data available for Gene Families for SPSB4 Gene

Function for SPSB4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for SPSB4 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes for SPSB4 Gene

GenomeRNAi human phenotypes for SPSB4:
genes like me logo Genes that share phenotypes with SPSB4: view

Animal Model Products

miRNA for SPSB4 Gene

miRTarBase miRNAs that target SPSB4

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPSB4 Gene

Localization for SPSB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPSB4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPSB4 Gene COMPARTMENTS Subcellular localization image for SPSB4 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SPSB4 Gene

Pathways & Interactions for SPSB4 Gene

genes like me logo Genes that share pathways with SPSB4: view

UniProtKB/Swiss-Prot Q96A44-SPSB4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPSB4 Gene

None

No data available for SIGNOR curated interactions for SPSB4 Gene

Drugs & Compounds for SPSB4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for SPSB4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for SPSB4 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(46) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPSB4 Gene

SplA/ryanodine receptor domain and SOCS box containing 4:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB4 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: - - -
SP3:

Relevant External Links for SPSB4 Gene

GeneLoc Exon Structure for
SPSB4
ECgene alternative splicing isoforms for
SPSB4

Expression for SPSB4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for SPSB4 Gene

mRNA expression in normal human tissues for SPSB4 Gene
mRNA expression by BioGPS for SPSB4 GenemRNA expression by GTEx for SPSB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPSB4 Gene

This gene is overexpressed in Pancreas (x11.5), Testis (x6.7), and Pituitary (x6.5).

SOURCE GeneReport for Unigene cluster for SPSB4 Gene Hs.655112

genes like me logo Genes that share expression patterns with SPSB4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPSB4 Gene

Orthologs for SPSB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia SPSB4 35
  • 92.31 (n)
  • 97.44 (a)
SPSB4 36
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia SPSB4 35
  • 93.41 (n)
  • 96.7 (a)
SPSB4 36
  • 97 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Spsb4 35
  • 88.03 (n)
  • 97.8 (a)
Spsb4 16
Spsb4 36
  • 98 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia SPSB4 35
  • 99.63 (n)
  • 100 (a)
SPSB4 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Spsb4 35
  • 86.94 (n)
  • 97.8 (a)
oppossum
(Monodelphis domestica)
 Mammalia SPSB4 36
  • 85 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia SPSB4 36
  • 82 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves SPSB4 35
  • 71.31 (n)
  • 81.32 (a)
SPSB4 36
  • 76 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia SPSB4 36
  • 82 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia spsb4 35
  • 69.35 (n)
  • 80.59 (a)
zebrafish
(Danio rerio)
 Actinopterygii nszf-e326 35
spsb4a 35
  • 73.02 (n)
  • 79.12 (a)
spsb4a 36
  • 78 (a)
 OneToMany
spsb4b 36
  • 67 (a)
 OneToMany
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP010197 35
  • 65.2 (n)
  • 68.01 (a)
fruit fly
(Drosophila melanogaster)
 Insecta gus 35
  • 58.21 (n)
  • 69.49 (a)
gus 36
  • 67 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea spsb-1 35
  • 57.83 (n)
  • 58.5 (a)
spsb-1 36
  • 27 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.8004 36
  • 51 (a)
 OneToMany
Species with no ortholog for SPSB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPSB4 Gene

ENSEMBL:
Gene Tree for SPSB4 (if available)
TreeFam:
Gene Tree for SPSB4 (if available)

Paralogs for SPSB4 Gene

Paralogs for SPSB4 Gene

(37) SIMAP similar genes for SPSB4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPSB4: view

Variants for SPSB4 Gene

Sequence variations from dbSNP and Humsavar for SPSB4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs2291042 -- 141,148,252(-) CAAAC(C/T)TGTAG utr-variant-3-prime
rs2291043 -- 141,147,789(-) GCACA(A/G)AGTCC downstream-variant-500B, utr-variant-3-prime
rs2311492 -- 141,051,054(+) CCAGG(A/C)GCGCT intron-variant, upstream-variant-2KB
rs2311493 -- 141,051,124(+) GCGAG(C/T)GGGCG intron-variant, upstream-variant-2KB
rs2311494 -- 141,096,074(+) ACCAG(G/T)TGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPSB4 Gene

Variant ID Type Subtype PubMed ID
esv22188 CNV Loss 19812545
nsv877550 CNV Gain 21882294

Variation tolerance for SPSB4 Gene

Gene Damage Index Score: 1.61; 30.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPSB4 Gene

Disorders for SPSB4 Gene

Relevant External Links for SPSB4

Genetic Association Database (GAD)
SPSB4
Human Genome Epidemiology (HuGE) Navigator
SPSB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPSB4

No disorders were found for SPSB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB4 Gene

Publications for SPSB4 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 3 4 23 67
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. (PMID: 24262325) Dichgans M. … . (Stroke 2014) 3
  4. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. (PMID: 23041239) Traylor M. … Markus H.S. (Lancet Neurol 2012) 3
  5. Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PMID: 21199876) Nishiya T. … Miwa S. (J. Biol. Chem. 2011) 3

Products for SPSB4 Gene

  • Addgene plasmids for SPSB4

Sources for SPSB4 Gene

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