Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SPSB4 Gene

protein-coding   GIFtS: 49
GCID: GC03P140770

SplA/Ryanodine Receptor Domain And SOCS Box Containing 4

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
SplA/Ryanodine Receptor Domain And SOCS Box Containing 41 2
SSB42 3 5
SSB-42 3
SPRY Domain-Containing SOCS Box Protein 42
SPRY Domain-Containing SOCS Box Protein SSB-42

External Ids:    HGNC: 306301   Entrez Gene: 923692   Ensembl: ENSG000001750937   OMIM: 6116605   UniProtKB: Q96A443   

Export aliases for SPSB4 gene to outside databases

Previous GC identifers: GC03P142253 GC03P138145


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SPSB4 Gene:
SPSB4 (splA/ryanodine receptor domain and SOCS box containing 4) is a protein-coding gene. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPSB4 gene promoter:
         NF-1/L   NF-1   Spz1   Lmo2   HSF1 (long)   XBP-1   Nkx6-1   HSF1short   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPSB4 promoter sequence
   Search Chromatin IP Primers for SPSB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPSB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

SPSB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPSB4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P140770:  view genomic region     (about GC identifiers)

Start:
140,770,244 bp from pter      End:
140,867,453 bp from pter
Size:
97,210 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44 (See protein sequence)
Recommended Name: SPRY domain-containing SOCS box protein 4  
Size: 273 amino acids; 30179 Da
Subunit: Interacts with PARW (By similarity). Probable component of the ECS(SPSB4) E3 ubiquitin-protein ligase
complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB4. Interacts with MET
1 PDB 3D structure from and Proteopedia for SPSB4:
2V24 (3D)    

Explore the universe of human proteins at neXtProt for SPSB4: NX_Q96A44

Explore proteomics data for SPSB4 at MOPED


See SPSB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_543138.1  
ENSEMBL proteins: 
 ENSP00000311609   ENSP00000422034  
Reactome Protein details: Q96A44

SPSB4 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein for SPSB4
Browse OriGene Protein Over-expression Lysates
OriGene MassSpec for SPSB4
OriGene Custom Protein Services for SPSB4
GenScript Custom Purified and Recombinant Proteins Services for SPSB4
Novus Biologicals SPSB4 Protein
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for SPSB4

 
Search eBioscience for Proteins for SPSB4 

 
antibodies-online proteins for SPSB4 (4 products) 

 
Search antibodies-online for peptides for SPSB4

SPSB4 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for SPSB4
Search for Antibodies for SPSB4 at Abcam
Cloud-Clone Corp. Antibodies for SPSB4
Search ThermoFisher Antibodies for SPSB4
Search antibodies-online for antibodies for SPSB4 

SPSB4 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for SPSB4
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for SPSB4
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for SPSB4
Cloud-Clone Corp. CLIAs for SPSB4
Search eBioscience for ELISAs for SPSB4 
antibodies-online kits for SPSB4 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
5 InterPro protein domains:
 IPR001870 B30.2/SPRY
 IPR003877 SPRY_rcpt
 IPR001496 SOCS_C
 IPR018355 SPla/RYanodine_receptor_subgr
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q96A44

ProtoNet protein and cluster: Q96A44

1 Blocks protein domain: IPB001496 SOCS protein

UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin ligase complexes (By similarity)
Similarity: Belongs to the SPSB family
Similarity: Contains 1 B30.2/SPRY domain
Similarity: Contains 1 SOCS box domain


Find genes that share domains with SPSB4           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPSB4_HUMAN, Q96A44
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI15601820
     
Find genes that share ontologies with SPSB4           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for SPSB4

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat SPSB4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SPSB4 (see all 38):
hsa-miR-4307 hsa-miR-15a hsa-miR-29a hsa-miR-632 hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-1298
SwitchGear 3'UTR luciferase reporter plasmidSPSB4 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for SPSB4
Predesigned siRNA for gene silencing in human, mouse, rat SPSB4

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for SPSB4

Clone
Products:
     
OriGene clones in human, mouse for SPSB4 (see all 6)
OriGene ORF clones in mouse, rat for SPSB4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPSB4 (NM_080862)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPSB4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB4
Addgene plasmids for SPSB4 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for SPSB4
Browse ESI BIO Cell Lines and PureStem Progenitors for SPSB4 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
SPSB4_HUMAN, Q96A44: Cytoplasm (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol2
nucleus2
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm IEA--

Find genes that share ontologies with SPSB4           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for SPSB4 About    
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84


Find genes that share SuperPaths with SPSB4           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for SPSB4
    Antigen processing: Ubiquitination & Proteasome degradation


UniProtKB/Swiss-Prot: SPSB4_HUMAN, Q96A44
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Array including SPSB4: 

          Ubiquitin Ligases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for SPSB4

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for SPSB4 (Q96A441, 3 ENSP000003116094) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
TCEB1Q153691, 3, ENSP000002848114EBI-2323233,EBI-301231 I2D: score=2 STRING: ENSP00000284811
NOS2P352283, ENSP000003272514I2D: score=1 STRING: ENSP00000327251
RNF7Q9UBF63, ENSP000002734804I2D: score=1 STRING: ENSP00000273480
TCEB2Q153703, ENSP000002623064I2D: score=1 STRING: ENSP00000262306
CUL5Q930343I2D: score=1 
About this table

Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0035556intracellular signal transduction IEA--

Find genes that share ontologies with SPSB4           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPSB4



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SPSB4 gene: 
NM_080862.1  

Unigene Cluster for SPSB4:

SplA/ryanodine receptor domain and SOCS box containing 4
Hs.655112  [show with all ESTs]
Unigene Representative Sequence: BC051354
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000310546(uc003ett.3 uc010hum.3) ENST00000508126 ENST00000508828
ENST00000507895
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat SPSB4 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate SPSB4 (see all 38):
hsa-miR-4307 hsa-miR-15a hsa-miR-29a hsa-miR-632 hsa-miR-424 hsa-miR-23a hsa-miR-15b hsa-miR-1298
SwitchGear 3'UTR luciferase reporter plasmidSPSB4 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for SPSB4
Predesigned siRNA for gene silencing in human, mouse, rat SPSB4
Clone
Products:
     
OriGene clones in human, mouse for SPSB4 (see all 6)
OriGene ORF clones in mouse, rat for SPSB4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: SPSB4 (NM_080862)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPSB4
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB4
Addgene plasmids for SPSB4 
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPSB4
  QuantiTect SYBR Green Assays in human, mouse, rat SPSB4
  QuantiFast Probe-based Assays in human, mouse, rat SPSB4

Additional mRNA sequence: 

AF086345.1 AF403029.1 AK056147.1 AK056367.1 BC008324.1 BC051354.1 

4 DOTS entries:

DT.97791370  DT.100684548  DT.309089  DT.433213 

Selected AceView cDNA sequences (see all 46):

AW293029 BM929361 AA757366 CR613017 AI369332 CR593903 AA581737 AA405736 
BX351403 AF403029 BG826825 AI598224 W72267 AF086345 BG829052 NM_080862 
AW411014 AA405968 BX112094 BC008324 AI277923 AK056367 BE261590 AI190669 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SPSB4    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1:                    -     -               
SP2:                    -     -     -         
SP3:                                          


ECgene alternative splicing isoforms for SPSB4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SPSB4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGGCAGCCT
SPSB4 Expression
About this image


SPSB4 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Neurons
         nGnG Amacrine Cells Inner Nuclear Layer
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         nGnG Amacrine Cells Inner Nuclear Layer
 
 Lung (Respiratory System)
         Basal Cells Trachea
 
 Liver (Hepatobiliary System)
         Mesothelial Cells Hepatic Mesenchyme
 
 Brain (Nervous System)
         Adult Oligodendrocyte Precursor Cells Lateral Ventricle
SPSB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPSB4 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.655112
    Pathway & Disease-focused RT2 Profiler PCR Array including SPSB4: 
          Ubiquitin Ligases in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPSB4
QuantiTect SYBR Green Assays in human, mouse, rat SPSB4
QuantiFast Probe-based Assays in human, mouse, rat SPSB4
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for SPSB4 gene from Selected species (see all 15)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spsb41 , 5 splA/ryanodine receptor domain and SOCS box containing more1, 5 88.03(n)1
97.8(a)1
  9 (50.74 cM)5
2119491  NM_145134.31  NP_660116.11 
 969434825 
chicken
(Gallus gallus)
Aves SPSB41 splA/ryanodine receptor domain and SOCS box containing more 71.31(n)
81.32(a)
  429129  XM_426685.3  XP_426685.2 
lizard
(Anolis carolinensis)
Reptilia SPSB46
splA/ryanodine receptor domain and SOCS box contai...
82(a)
1 ↔ 1
GL343404.1(631397-710596)
tropical clawed frog
(Xenopus tropicalis)
Amphibia spsb41 splA/ryanodine receptor domain and SOCS box containing more 69.35(n)
80.59(a)
  100496912  XM_002941296.2  XP_002941342.1 
zebrafish
(Danio rerio)
Actinopterygii nszf-e3262 nszf-e326 73.91(n)   335778  CF996573.1 
fruit fly
(Drosophila melanogaster)
Insecta gus1 gustavus 58.21(n)
69.49(a)
  35478  NM_165420.3  NP_724400.2 
worm
(Caenorhabditis elegans)
Secernentea spsb-11 spsb-1 57.83(n)
58.5(a)
  266876  NM_064920.4  NP_497321.3 


ENSEMBL Gene Tree for SPSB4 (if available)
TreeFam Gene Tree for SPSB4 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for SPSB4 gene
SPSB22  FBXO452  SPSB12  
Selected SIMAP similar genes for SPSB4 using alignment to 2 protein entries:     SPSB4_HUMAN (see all proteins) (see all similar genes):
COX7A2    IPO7    ZNF568    ZNF83    SPSB1    ZNF738
TMEM67    ECD    CES4A    THADA    IFT122    TGFBR3
C12orf23    DAPK2    NDUFS7    NSD1    SENP7    ZNF23

Find genes that share paralogs with SPSB4           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for SPSB4 (see all 1882)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1917204651,2
--138143615(+) CAGGGC/TATCCA 1 -- int10--------
rs1846364481,2
--138143730(+) AATACG/TTGTCA 1 -- int10--------
rs1123980781,2
C,F--138143738(+) TCAATG/ACACAC 1 -- int11Minor allele frequency- A:0.50CSA 2
rs1488092831,2
--138143863(+) GGTCTC/TTCTGG 1 -- int10--------
rs1424577101,2
--138143891(+) GTCACC/TACCCT 1 -- int10--------
rs1889585361,2
--138143895(+) CTACCC/TTGGTT 1 -- int10--------
rs1513148381,2
--138143968(+) GACACC/GGTCCA 1 -- int10--------
rs1393668081,2
--138143987(+) GTTCCC/GTCATA 1 -- int10--------
rs1932686351,2
C--138143996(+) TACCCA/CCTCTG 1 -- int10--------
rs1500283281,2
--138144145(+) CCAGAA/GCCTCT 1 -- int10--------

HapMap Linkage Disequilibrium report for SPSB4 (140770244 - 140867453 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for SPSB4:    About this table    
Variant IDTypeSubtypePubMed ID
esv22188CNV Loss19812545
nsv877550CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SPSB4
DNA2.0 Custom Variant and Variant Library Synthesis for SPSB4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 611660    OMIM disorders: --


Find genes that share disorders with SPSB4           About GenesLikeMe

Genetic Association Database (GAD): SPSB4
Human Genome Epidemiology (HuGE) Navigator: SPSB4 (1 document)

Export disorders for SPSB4 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SPSB4 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with SPSB4)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2, 9 Wang D.... Wu G. (J. Biol. Chem. 2005)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (Genes Dev. 2004)
  6. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
  7. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. (PubMed id 23041239)1 Traylor M....Markus H.S. (Lancet Neurol 2012)
  8. Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PubMed id 21199876)1 Nishiya T....Miwa S. (J. Biol. Chem. 2011)
  9. The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation. (PubMed id 20603330)1 Kuang Z....Nicholson S.E. (J. Cell Biol. 2010)
  10. Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. (PubMed id 20561531)1 Filippakopoulos P....Bullock A.N. (J. Mol. Biol. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 92369 HGNC: 30630 AceView: SSB4 Ensembl:ENSG00000175093 euGenes: HUgn92369
ECgene: SPSB4 H-InvDB: SPSB4

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for SPSB4 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for SPSB4 gene:
Search GeneIP for patents involving SPSB4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPSB4  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene MassSpec for SPSB4   OriGene clones in human, mouse for SPSB4  
 OriGene qSTAR qPCR primer pairs in human, mouse for SPSB4   OriGene Purified Protein for SPSB4  
 OriGene ORF clones in mouse, rat for SPSB4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for SPSB4   OriGene Custom Protein Services for SPSB4  

 
 
 Block miRNA regulation of human, mouse, rat SPSB4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPSB4
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPSB4 Predesigned siRNA for gene silencing in human, mouse, rat SPSB4
 QuantiFast Probe-based Assays in human, mouse, rat SPSB4 QuantiTect SYBR Green Assays in human, mouse, rat SPSB4
 PCR Arrays including human, mouse, rat SPSB4 Search Chromatin IP Primers for SPSB4
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPSB4  Search GeneGlobe Interaction Network for SPSB4
 Regulatory tfbs in SPSB4 promoter
 GenScript Custom Purified and Recombinant Proteins Services for SPSB4 GenScript cDNA clones with any tag delivered in your preferred vector for SPSB4
 GenScript Custom Assay Services for SPSB4 GenScript Custom overexpressing Cell Line Services for SPSB4
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for SPSB4
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 SPSB4 proteins
 Search for Antibodies for SPSB4 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for SPSB4
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for SPSB4
 Antibodies for SPSB4
 ELISAs for SPSB4
 CLIAs for SPSB4



 Browse ESI BIO Cell Lines and PureStem Progenitors for SPSB4
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB4
 SwitchGear 3'UTR luciferase reporter plasmids for SPSB4
 SwitchGear Promoter luciferase reporter plasmids for SPSB4
 Search ThermoFisher Antibodies for SPSB4
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB4
 Browse compounds at ApexBio
 Addgene plasmids for SPSB4
  Search eBioscience for proteins for SPSB4
  Search eBioscience for elisas for SPSB4
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for SPSB4
  Search antibodies-online for antibodies for SPSB4
 antibodies-online kits for SPSB4 (4 products)
  Search antibodies-online for peptides for SPSB4
 antibodies-online proteins for SPSB4 (4 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      SPSB4 gene at Home site.
Version: 3.12.248 16 Nov 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4