SPSB3 Gene
protein-coding GIFtS: 48
GCID: GC16M001826
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splA/ryanodine receptor domain and SOCS box containing 3(Previous name: chromosome 16 open reading frame 31 )
(Previous symbol: C16orf31)
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Aliases
for SPSB3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| SplA/Ryanodine Receptor Domain And SOCS Box Containing 31 2 | | Chromosome 16 Open Reading Frame 311 | | C16orf311 2 3 | | SPRY Domain-Containing SOCS Box Protein 32 | | SSB32 3 5 | | SPRY Domain-Containing SOCS Box Protein SSB-32 | | SSB-31 3 | | |
Export aliases for SPSB3 gene to outside databasesPrevious GC identifer: GC16M001768 |
Summaries
for SPSB3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPSB3_HUMAN, Q6PJ21Function: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)
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Genomic Views
for SPSB3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPSB3 gene promoter:
STAT1 Pax-5 STAT4 STAT1beta Olf-1 STAT1alpha YY1 CP2 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPSB3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPSB3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3SPSB3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M001826: view genomic region
(about GC identifiers)
Start:
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1,826,713 bp from pter |
End:
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1,832,821 bp from pter |
Size:
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6,109 bases |
Orientation:
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minus strand |
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Proteins
for SPSB3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPSB3_HUMAN, Q6PJ21 (See
protein sequence)Recommended Name: SPRY domain-containing SOCS box protein 3 Size: 355 amino acids; 39376 Da
Subunit: Interacts with MET
Sequence caution: Sequence=AAH41897.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=AAK61293.1;Type=Erroneous gene model prediction;
Secondary accessions: D3DU78 Q49A96 Q86X18 Q8WXK5 Q96IE6 Q96RY2Explore the universe of human proteins at neXtProt for SPSB3: NX_Q6PJ21
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PJ21
SPSB3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_543137.2
ENSEMBL proteins: ENSP00000457206 ENSP00000301717
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
SPSB3 for ontologies About GeneDecksing
SPSB3 Antibody Products:
Assay Products for SPSB3: |
Protein
Domains /
Families
for SPSB3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPSB3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PJ21ProtoNet protein and cluster: Q6PJ21 1 Blocks protein family: IPB001496 SOCS protein
UniProtKB/Swiss-Prot: SPSB3_HUMAN, Q6PJ21Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin ligase complexes (By similarity)Similarity: Belongs to the SPSB familySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 SOCS box domain |
Function
for SPSB3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPSB3_HUMAN, Q6PJ21Function: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of targetproteins (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPSB3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPSB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPSB3 (NM_080861) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPSB3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB3 |
2 GenomeRNAi human phenotypes for SPSB3:
|
Pathways & Interactions
for SPSB3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: SPSB3_HUMAN, Q6PJ21Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPSB3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for SPSB3 (Q6PJ213 ENSP000003017174) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- | | GO:0035556 | intracellular signal transduction |
IEA | -- |
SPSB3 for ontologies About GeneDecksing
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Drugs & Compounds
for SPSB3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPSB3
Search CenterWatch for drugs/clinical trials and news about SPSB3
|
Transcripts
for SPSB3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPSB3 gene: NM_080861.3 Unigene Cluster for SPSB3: SplA/ryanodine receptor domain and SOCS box containing 3 Hs.592080 [show with all ESTs]Unigene Representative Sequence: BC04189711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000566339(uc002cmu.3) ENST00000564709(uc002cmt.3) ENST00000569380(uc010uvm.2)
ENST00000567868 ENST00000563741 ENST00000301717 ENST00000563668 ENST00000563705
ENST00000565550 ENST00000564070 ENST00000568416
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPSB3 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPSB3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPSB3 (NM_080861) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPSB3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB3 |
Additional cDNA sequence: AF403028.1 AK074190.1 AK302041.1 BC007588.1 BC024244.1 BC035065.1 BC041897.1 BC047441.1 BC065515.1 18 DOTS entries: DT.446875 DT.100820574 DT.100820578 DT.97854693 DT.100820565 DT.75157124 DT.100763039 DT.100820559 DT.100820560 DT.120716774 DT.100820580 DT.120716731 DT.453906 DT.95266595 DT.91752999 DT.95266587 DT.95266597 DT.95266583 24/35 AceView cDNA sequences (see all 35): CR620383 CR596537 AF403028 CR609820 CR604082 CR610957 CR591468 CR605628 CR612312 CR590538 CR595592 BC041897 CR601897 CR622113 CR617347 CR592259 CR594533 CR598252 BC065515 CR624932 BC007588 NM_080861 CR594897 CR611923
GeneLoc Exon Structure
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Expression
for SPSB3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPSB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTCAGCGG
About this image
See SPSB3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPSB3
SOURCE GeneReport for Unigene cluster: Hs.592080
SABiosciences Custom PCR Arrays for SPSB3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPSB3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPSB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPSB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB3 |
Orthologs
for SPSB3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SPSB3 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for SPSB3 (if available)
TreeFam Gene Tree for SPSB3 (if available) |
Paralogs
for SPSB3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPSB3 gene
- ENSG000002616612
SPSB3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SPSB3
PGOHUM00000262924
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Genomic Variants
for SPSB3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPSB3 (1826713 - 1832821 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SPSB3
5 CNVs: 49667 29999 5329 49668 49666 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPSB3 |
|
Disorders
/ Diseases
for SPSB3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPSB3 for disorders About GeneDecksing
OMIM gene information: 611659
OMIM disorders: --
3  diseases for SPSB3: About MalaCardsscabies brucellosis obesity
Human Genome Epidemiology (HuGE) Navigator: SPSB3 (1 document)
Export disorders for SPSB3 gene to outside databases
|
Publications
for SPSB3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPSB3 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with SPSB3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2, 9 Wang D....Wu G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
- Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
- Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PubMed id 21199876)1 Nishiya T....Miwa S. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Use of genome-wide expression data to mine the ' Gray Zone' of GWA studies leads to novel candidate obesity genes. (PubMed id 20532202)1 Naukkarinen J....Peltonen L. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SPSB3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPSB3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPSB3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPSB3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPSB3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPSB3 gene:
Search GeneIP for patents involving SPSB3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPSB3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPSB3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPSB3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPSB3 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for SPSB3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPSB3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPSB3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPSB3 | | OriGene Custom Protein Services for SPSB3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPSB3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPSB3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPSB3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPSB3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPSB3 |
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| | | | Search Tocris compounds for SPSB3 |
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 | | | SPSB3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB3 |
|  |  |  | | | | ThermoFisher Antibodies for SPSB3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB3 |
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