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Aliases for SPSB3 Gene

Aliases for SPSB3 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 3 2 3 5
  • C16orf31 3 4
  • SSB3 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-3 3
  • SPRY Domain-Containing SOCS Box Protein 3 3
  • Chromosome 16 Open Reading Frame 31 2
  • SSB-3 4

External Ids for SPSB3 Gene

Previous HGNC Symbols for SPSB3 Gene

  • C16orf31

Previous GeneCards Identifiers for SPSB3 Gene

  • GC16M001768
  • GC16M001826

Summaries for SPSB3 Gene

GeneCards Summary for SPSB3 Gene

SPSB3 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPSB3 Gene

  • May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Additional gene information for SPSB3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB3 Gene

Genomics for SPSB3 Gene

Regulatory Elements for SPSB3 Gene

Enhancers for SPSB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H002147 2 FANTOM5 Ensembl ENCODE dbSUPER 25.4 -362.1 -362091 17.4 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC CRAMP1 ENSG00000260051 ENSG00000261505 TELO2 TBL3 UNKL E4F1 TSC2 SRRM2 ZNF213-AS1
GH16H001308 1.4 ENCODE dbSUPER 35.2 +482.9 482946 5.2 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 MCM3 NFYC WDR90 CRAMP1 ENSG00000261505 TELO2 UBE2I E4F1 TSC2 ENSG00000260051 JMJD8 RHOT2
GH16H001271 1.1 ENCODE 35.2 +521.9 521874 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF302 ZNF416 SP3 REST ZNF662 ZNF592 CRAMP1 WDR90 TELO2 IFT140 ENSG00000261505 TSC2 E4F1 WDR24 ENSG00000260646 UBE2I
GH16H001962 1.4 Ensembl ENCODE 25 -170.5 -170522 4.1 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ENSG00000255513 ENSG00000261505 ENSG00000260051 TELO2 E4F1 UNKL TSC2 SNHG9 CRAMP1 SRRM2
GH16H002266 1.2 ENCODE 23.5 -474.5 -474512 3.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263 UBE2I UNKL ENSG00000261505 TSC2 E4F1 ENSG00000260051 TBL3 CRAMP1 AMDHD2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPSB3 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SPSB3 Gene

Genomic Locations for SPSB3 Gene
chr16:1,776,712-1,793,700
(GRCh38/hg38)
Size:
16,989 bases
Orientation:
Minus strand
chr16:1,826,713-1,843,701
(GRCh37/hg19)

Genomic View for SPSB3 Gene

Genes around SPSB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPSB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPSB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB3 Gene

Proteins for SPSB3 Gene

  • Protein details for SPSB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJ21-SPSB3_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 3
    Protein Accession:
    Q6PJ21
    Secondary Accessions:
    • D3DU78
    • Q49A96
    • Q86X18
    • Q8WXK5
    • Q96IE6
    • Q96RY2

    Protein attributes for SPSB3 Gene

    Size:
    355 amino acids
    Molecular mass:
    39376 Da
    Quaternary structure:
    • Interacts with MET.
    SequenceCaution:
    • Sequence=AAH41897.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAK61293.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SPSB3 Gene

Post-translational modifications for SPSB3 Gene

  • Ubiquitination at Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for SPSB3 Gene

No data available for DME Specific Peptides for SPSB3 Gene

Domains & Families for SPSB3 Gene

Gene Families for SPSB3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPSB3 Gene

Suggested Antigen Peptide Sequences for SPSB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PJ21

UniProtKB/Swiss-Prot:

SPSB3_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the SPSB family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Family:
  • Belongs to the SPSB family.
genes like me logo Genes that share domains with SPSB3: view

Function for SPSB3 Gene

Molecular function for SPSB3 Gene

UniProtKB/Swiss-Prot Function:
May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for SPSB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPSB3: view
genes like me logo Genes that share phenotypes with SPSB3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPSB3 Gene

Localization for SPSB3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPSB3 gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPSB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SPSB3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPSB3 Gene

Pathways & Interactions for SPSB3 Gene

SuperPathways for SPSB3 Gene

No Data Available

UniProtKB/Swiss-Prot Q6PJ21-SPSB3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPSB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SPSB3: view

No data available for Pathways by source and SIGNOR curated interactions for SPSB3 Gene

Drugs & Compounds for SPSB3 Gene

No Compound Related Data Available

Transcripts for SPSB3 Gene

Unigene Clusters for SPSB3 Gene

SplA/ryanodine receptor domain and SOCS box containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB3 Gene

No ASD Table

Relevant External Links for SPSB3 Gene

GeneLoc Exon Structure for
SPSB3
ECgene alternative splicing isoforms for
SPSB3

Expression for SPSB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPSB3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPSB3 Gene



Protein tissue co-expression partners for SPSB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPSB3 Gene:

SPSB3

SOURCE GeneReport for Unigene cluster for SPSB3 Gene:

Hs.592080

Evidence on tissue expression from TISSUES for SPSB3 Gene

  • Nervous system(4.9)
  • Eye(4)
  • Pancreas(3.6)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SPSB3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPSB3 Gene

Orthologs for SPSB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPSB3 33 34
  • 98.78 (n)
cow
(Bos Taurus)
Mammalia SPSB3 33 34
  • 88.45 (n)
dog
(Canis familiaris)
Mammalia SPSB3 33 34
  • 86.97 (n)
mouse
(Mus musculus)
Mammalia Spsb3 33 16 34
  • 83.62 (n)
rat
(Rattus norvegicus)
Mammalia Spsb3 33
  • 83.19 (n)
oppossum
(Monodelphis domestica)
Mammalia SPSB3 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPSB3 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPSB3 33 34
  • 78.25 (n)
lizard
(Anolis carolinensis)
Reptilia SPSB3 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spsb3 33
  • 71.01 (n)
zebrafish
(Danio rerio)
Actinopterygii spsb3a 34 33
  • 68.17 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10516 33 34
  • 49.52 (n)
Species where no ortholog for SPSB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPSB3 Gene

ENSEMBL:
Gene Tree for SPSB3 (if available)
TreeFam:
Gene Tree for SPSB3 (if available)

Paralogs for SPSB3 Gene

No data available for Paralogs for SPSB3 Gene

Variants for SPSB3 Gene

Sequence variations from dbSNP and Humsavar for SPSB3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000513546 -- 1,776,371(+) ACCTC(-/AG)GGGAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000560342 -- 1,778,867(+) CCTCC(A/G)AGTGG intron-variant
rs1000967235 -- 1,779,124(+) CGCCC(C/T)TCCTG intron-variant
rs1001138988 -- 1,784,052(+) CAGGA(C/T)GGATT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001221004 -- 1,780,501(+) CTGCA(A/G)ACAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPSB3 Gene

Variant ID Type Subtype PubMed ID
nsv952900 CNV deletion 24416366
nsv827500 CNV gain 20364138
nsv571173 CNV loss 21841781
nsv571172 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571170 CNV loss 21841781
nsv571169 CNV loss 21841781
nsv518641 CNV loss 19592680
nsv517196 CNV gain+loss 19592680
nsv471069 CNV loss 18288195
nsv457336 CNV loss 19166990
nsv457335 CNV loss 19166990
nsv1160328 CNV deletion 26073780
nsv1051692 CNV loss 25217958
esv3892756 CNV loss 25118596
esv2422427 CNV duplication 17116639
dgv4856n54 CNV loss 21841781

Variation tolerance for SPSB3 Gene

Residual Variation Intolerance Score: 19.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.41; 27.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPSB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPSB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB3 Gene

Disorders for SPSB3 Gene

Relevant External Links for SPSB3

Genetic Association Database (GAD)
SPSB3
Human Genome Epidemiology (HuGE) Navigator
SPSB3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPSB3

No disorders were found for SPSB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB3 Gene

Publications for SPSB3 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D … Wu G (The Journal of biological chemistry 2005) 3 4 22 60
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile BT … Hilton DJ (Trends in biochemical sciences 2002) 2 3 60
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 60

Products for SPSB3 Gene

Sources for SPSB3 Gene

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