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Aliases for SPSB3 Gene

Aliases for SPSB3 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 3 2 3
  • SSB3 3 4 6
  • C16orf31 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-3 3
  • SPRY Domain-Containing SOCS Box Protein 3 3
  • Chromosome 16 Open Reading Frame 31 2
  • SSB-3 4

External Ids for SPSB3 Gene

Previous HGNC Symbols for SPSB3 Gene

  • C16orf31

Previous GeneCards Identifiers for SPSB3 Gene

  • GC16M001768
  • GC16M001826

Summaries for SPSB3 Gene

GeneCards Summary for SPSB3 Gene

SPSB3 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPSB3 Gene

  • May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB3 Gene

Genomics for SPSB3 Gene

Regulatory Elements for SPSB3 Gene

Genomic Location for SPSB3 Gene

Start:
1,776,712 bp from pter
End:
1,793,700 bp from pter
Size:
16,989 bases
Orientation:
Minus strand

Genomic View for SPSB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPSB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB3 Gene

Proteins for SPSB3 Gene

  • Protein details for SPSB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJ21-SPSB3_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 3
    Protein Accession:
    Q6PJ21
    Secondary Accessions:
    • D3DU78
    • Q49A96
    • Q86X18
    • Q8WXK5
    • Q96IE6
    • Q96RY2

    Protein attributes for SPSB3 Gene

    Size:
    355 amino acids
    Molecular mass:
    39376 Da
    Quaternary structure:
    • Interacts with MET.
    SequenceCaution:
    • Sequence=AAH41897.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=AAK61293.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for SPSB3 Gene

Proteomics data for SPSB3 Gene at MOPED

Post-translational modifications for SPSB3 Gene

  • Ubiquitination at Lys142
  • Modification sites at PhosphoSitePlus

Other Protein References for SPSB3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPSB3 Gene

Domains for SPSB3 Gene

Protein Domains for SPSB3 Gene

Suggested Antigen Peptide Sequences for SPSB3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PJ21

UniProtKB/Swiss-Prot:

SPSB3_HUMAN :
  • Q6PJ21
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the SPSB family.
genes like me logo Genes that share domains with SPSB3: view

No data available for Gene Families for SPSB3 Gene

Function for SPSB3 Gene

Molecular function for SPSB3 Gene

UniProtKB/Swiss-Prot Function: May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for SPSB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with SPSB3: view

Phenotypes for SPSB3 Gene

genes like me logo Genes that share phenotypes with SPSB3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPSB3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPSB3 Gene

Localization for SPSB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPSB3 Gene COMPARTMENTS Subcellular localization image for SPSB3 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPSB3 Gene

Pathways for SPSB3 Gene

SuperPathways for SPSB3 Gene

No Data Available

UniProtKB/Swiss-Prot Q6PJ21-SPSB3_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SPSB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SPSB3: view

No data available for Pathways by source for SPSB3 Gene

Transcripts for SPSB3 Gene

Unigene Clusters for SPSB3 Gene

SplA/ryanodine receptor domain and SOCS box containing 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPSB3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPSB3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB3 Gene

No ASD Table

Relevant External Links for SPSB3 Gene

GeneLoc Exon Structure for
SPSB3
ECgene alternative splicing isoforms for
SPSB3

Expression for SPSB3 Gene

mRNA expression in normal human tissues for SPSB3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPSB3 Gene

SOURCE GeneReport for Unigene cluster for SPSB3 Gene Hs.592080

genes like me logo Genes that share expressions with SPSB3: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPSB3 Gene

Orthologs for SPSB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPSB3 35
  • 98.78 (n)
  • 99.44 (a)
SPSB3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPSB3 35
  • 88.45 (n)
  • 92.4 (a)
SPSB3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPSB3 35
  • 86.97 (n)
  • 89.52 (a)
SPSB3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spsb3 35
  • 83.62 (n)
  • 89.55 (a)
Spsb3 16
Spsb3 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPSB3 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPSB3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spsb3 35
  • 83.19 (n)
  • 89.58 (a)
chicken
(Gallus gallus)
Aves SPSB3 35
  • 78.25 (n)
  • 81.92 (a)
SPSB3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPSB3 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spsb3 35
  • 71.01 (n)
  • 75.35 (a)
zebrafish
(Danio rerio)
Actinopterygii spsb3a 35
  • 68.17 (n)
  • 69.49 (a)
spsb3a 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10516 35
  • 49.52 (n)
  • 39.92 (a)
CG10516 36
  • 29 (a)
OneToOne
Species with no ortholog for SPSB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPSB3 Gene

ENSEMBL:
Gene Tree for SPSB3 (if available)
TreeFam:
Gene Tree for SPSB3 (if available)

Paralogs for SPSB3 Gene

Pseudogenes.org Pseudogenes for SPSB3 Gene

genes like me logo Genes that share paralogs with SPSB3: view

No data available for Paralogs for SPSB3 Gene

Variants for SPSB3 Gene

Sequence variations from dbSNP and Humsavar for SPSB3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1178432 -- 1,777,835(+) CGCGA(C/T)GAGAA reference, synonymous-codon
rs1178433 -- 1,780,436(+) GGTCA(A/G)GGGCC intron-variant
rs1178434 -- 1,780,550(+) GCCTC(C/G)CTGAG intron-variant
rs1178435 -- 1,780,620(+) ACACA(C/T)ATATG intron-variant
rs3834960 -- 1,780,387(+) CTGCG(-/C)CCCGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPSB3 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv518641 CNV Loss 19592680
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
nsv457336 CNV Loss 19166990
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294

Relevant External Links for SPSB3 Gene

HapMap Linkage Disequilibrium report
SPSB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB3 Gene

Disorders for SPSB3 Gene

Relevant External Links for SPSB3

Genetic Association Database (GAD)
SPSB3
Human Genome Epidemiology (HuGE) Navigator
SPSB3
genes like me logo Genes that share disorders with SPSB3: view

No data available for UniProtKB/Swiss-Prot for SPSB3 Gene

Publications for SPSB3 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 3 4 23
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  3. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J. … Peltonen L. (PLoS Genet. 2010) 3 48

Products for SPSB3 Gene

Sources for SPSB3 Gene

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