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Aliases for SPSB2 Gene

Aliases for SPSB2 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 2 2 3 5
  • Gene-Rich Cluster Protein C9 3 4
  • GRCC9 3 4
  • SSB2 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-2 3
  • SSB-2 4

External Ids for SPSB2 Gene

Previous GeneCards Identifiers for SPSB2 Gene

  • GC12M006980

Summaries for SPSB2 Gene

Entrez Gene Summary for SPSB2 Gene

  • This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SPSB2 Gene

SPSB2 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 2) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is SPSB4.

UniProtKB/Swiss-Prot for SPSB2 Gene

  • Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB2 Gene

Genomics for SPSB2 Gene

Regulatory Elements for SPSB2 Gene

Enhancers for SPSB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPSB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPSB2 Gene

Chromosome:
12
Start:
6,870,935 bp from pter
End:
6,889,358 bp from pter
Size:
18,424 bases
Orientation:
Minus strand

Genomic View for SPSB2 Gene

Genes around SPSB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPSB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPSB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB2 Gene

Proteins for SPSB2 Gene

  • Protein details for SPSB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99619-SPSB2_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 2
    Protein Accession:
    Q99619
    Secondary Accessions:
    • B7Z4W1
    • D3DUT0

    Protein attributes for SPSB2 Gene

    Size:
    263 amino acids
    Molecular mass:
    28630 Da
    Quaternary structure:
    • Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with PAWR and MET.

    Three dimensional structures from OCA and Proteopedia for SPSB2 Gene

    Alternative splice isoforms for SPSB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPSB2 Gene

Proteomics data for SPSB2 Gene at MOPED

Post-translational modifications for SPSB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPSB2 Gene

No data available for DME Specific Peptides for SPSB2 Gene

Domains & Families for SPSB2 Gene

Protein Domains for SPSB2 Gene

Suggested Antigen Peptide Sequences for SPSB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99619

UniProtKB/Swiss-Prot:

SPSB2_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the SPSB family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the SPSB family.
genes like me logo Genes that share domains with SPSB2: view

No data available for Gene Families for SPSB2 Gene

Function for SPSB2 Gene

Molecular function for SPSB2 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
genes like me logo Genes that share phenotypes with SPSB2: view

Animal Models for SPSB2 Gene

MGI Knock Outs for SPSB2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPSB2 Gene

Localization for SPSB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPSB2 Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPSB2 Gene

Pathways & Interactions for SPSB2 Gene

genes like me logo Genes that share pathways with SPSB2: view

UniProtKB/Swiss-Prot Q99619-SPSB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPSB2: view

No data available for SIGNOR curated interactions for SPSB2 Gene

Drugs & Compounds for SPSB2 Gene

No Compound Related Data Available

Transcripts for SPSB2 Gene

Unigene Clusters for SPSB2 Gene

SplA/ryanodine receptor domain and SOCS box containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1: -
SP2: -

Relevant External Links for SPSB2 Gene

GeneLoc Exon Structure for
SPSB2
ECgene alternative splicing isoforms for
SPSB2

Expression for SPSB2 Gene

mRNA expression in normal human tissues for SPSB2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPSB2 Gene



SOURCE GeneReport for Unigene cluster for SPSB2 Gene Hs.479856

genes like me logo Genes that share expression patterns with SPSB2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPSB2 Gene

Orthologs for SPSB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPSB2 35
  • 91.18 (n)
  • 93.27 (a)
SPSB2 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPSB2 35
  • 93.41 (n)
  • 95.44 (a)
SPSB2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spsb2 35
  • 87.2 (n)
  • 90.87 (a)
Spsb2 16
Spsb2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPSB2 35
  • 98.99 (n)
  • 99.62 (a)
zebrafish
(Danio rerio)
Actinopterygii SPSB2 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gus 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spsb-2 36
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8004 36
  • 40 (a)
OneToMany
Species with no ortholog for SPSB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPSB2 Gene

ENSEMBL:
Gene Tree for SPSB2 (if available)
TreeFam:
Gene Tree for SPSB2 (if available)

Paralogs for SPSB2 Gene

Paralogs for SPSB2 Gene

(3) SIMAP similar genes for SPSB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPSB2: view

Variants for SPSB2 Gene

Sequence variations from dbSNP and Humsavar for SPSB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2071070 -- 6,871,768(+) CCCAG(A/G)GCCCC intron-variant, utr-variant-3-prime
rs7136152 -- 6,875,100(+) TAAGC(A/T)GTGAA upstream-variant-2KB
rs7138740 -- 6,874,600(+) aaaaa(A/T)ttttt upstream-variant-2KB
rs7300411 -- 6,874,003(+) TTACT(G/T)AGCCG upstream-variant-2KB
rs7308252 -- 6,871,787(+) CATCC(A/T)GAGGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPSB2 Gene

Variant ID Type Subtype PubMed ID
nsv832324 CNV Loss 17160897
dgv1353n71 CNV Loss 21882294
nsv898641 CNV Loss 21882294
nsv898642 CNV Loss 21882294

Variation tolerance for SPSB2 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.33; 81.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPSB2 Gene

HapMap Linkage Disequilibrium report
SPSB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB2 Gene

Disorders for SPSB2 Gene

Relevant External Links for SPSB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPSB2

No disorders were found for SPSB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB2 Gene

Publications for SPSB2 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 3 4 23 67
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PMID: 8723724) Ansari-Lari M.A. … Gibbs R.A. (Genome Res. 1996) 2 3
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for SPSB2 Gene

Sources for SPSB2 Gene

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