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Aliases for SPSB2 Gene

Aliases for SPSB2 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 2 2 3 5
  • Gene-Rich Cluster Protein C9 3 4
  • GRCC9 3 4
  • SSB2 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-2 3
  • SPRY Domain-Containing SOCS Box Protein 2 3
  • SSB-2 4

External Ids for SPSB2 Gene

Previous GeneCards Identifiers for SPSB2 Gene

  • GC12M006980

Summaries for SPSB2 Gene

Entrez Gene Summary for SPSB2 Gene

  • This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for SPSB2 Gene

SPSB2 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. An important paralog of this gene is SPSB1.

UniProtKB/Swiss-Prot for SPSB2 Gene

  • Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Additional gene information for SPSB2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB2 Gene

Genomics for SPSB2 Gene

Regulatory Elements for SPSB2 Gene

Enhancers for SPSB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006940 1.9 FANTOM5 ENCODE dbSUPER 52.1 -64.3 -64301 25 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF384 CHD4 ENSG00000219410 ENSG00000247853 SPSB2 NCAPD2 SCARNA12 ING4 ENSG00000256967 EMG1
GH12H006866 1.4 ENCODE dbSUPER 51.3 +19.1 19115 8 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 FOS SPSB2 ZNF384 ING4 ENSG00000219410 ATN1 ENSG00000247853 CHD4 P3H3 LOC100419928 NCAPD2
GH12H006890 1.8 FANTOM5 Ensembl ENCODE 35 -1.8 -1781 1 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 SPSB2 ZNF384 CHD4 ENSG00000219410 ENSG00000247853 NOP2 SCARNA12 ACRBP CD4 PEX5
GH12H006849 1.7 FANTOM5 ENCODE dbSUPER 34.7 +36.9 36911 5 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SPSB2 ZNF384 CHD4 NOP2 TNFRSF1A EMG1 ENSG00000247853 CDCA3 TPI1 USP5
GH12H006530 1.4 ENCODE dbSUPER 34 +352.3 352263 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF384 CHD4 ENSG00000219410 NCAPD2 ENSG00000247853 NOP2 SPSB2 MRPL51 ENSG00000256967 ING4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPSB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPSB2 Gene

Chromosome:
12
Start:
6,870,935 bp from pter
End:
6,889,358 bp from pter
Size:
18,424 bases
Orientation:
Minus strand

Genomic View for SPSB2 Gene

Genes around SPSB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPSB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPSB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB2 Gene

Proteins for SPSB2 Gene

  • Protein details for SPSB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99619-SPSB2_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 2
    Protein Accession:
    Q99619
    Secondary Accessions:
    • B7Z4W1
    • D3DUT0

    Protein attributes for SPSB2 Gene

    Size:
    263 amino acids
    Molecular mass:
    28630 Da
    Quaternary structure:
    • Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB2 (PubMed:15601820). Interacts with CUL5, RNF7, ELOB and ELOC (PubMed:15601820). Interacts with MET (PubMed:15713673). Interacts (via B30.2/SPRY domain) with PAWR; this interaction occurs in association with the Elongin BC complex (PubMed:16498413, PubMed:20561531).

    Three dimensional structures from OCA and Proteopedia for SPSB2 Gene

    Alternative splice isoforms for SPSB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPSB2 Gene

Post-translational modifications for SPSB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPSB2 Gene

No data available for DME Specific Peptides for SPSB2 Gene

Domains & Families for SPSB2 Gene

Gene Families for SPSB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPSB2 Gene

Suggested Antigen Peptide Sequences for SPSB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q99619

UniProtKB/Swiss-Prot:

SPSB2_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the SPSB family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Family:
  • Belongs to the SPSB family.
genes like me logo Genes that share domains with SPSB2: view

Function for SPSB2 Gene

Molecular function for SPSB2 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes From GWAS Catalog for SPSB2 Gene

Gene Ontology (GO) - Molecular Function for SPSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 15601820
genes like me logo Genes that share ontologies with SPSB2: view
genes like me logo Genes that share phenotypes with SPSB2: view

Animal Models for SPSB2 Gene

MGI Knock Outs for SPSB2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPSB2
  • Applied Biological Materials Clones for SPSB2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPSB2 Gene

Localization for SPSB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPSB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPSB2 gene
Compartment Confidence
cytosol 4

Gene Ontology (GO) - Cellular Components for SPSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with SPSB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPSB2 Gene

Pathways & Interactions for SPSB2 Gene

genes like me logo Genes that share pathways with SPSB2: view

UniProtKB/Swiss-Prot Q99619-SPSB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPSB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SPSB2: view

No data available for SIGNOR curated interactions for SPSB2 Gene

Drugs & Compounds for SPSB2 Gene

No Compound Related Data Available

Transcripts for SPSB2 Gene

Unigene Clusters for SPSB2 Gene

SplA/ryanodine receptor domain and SOCS box containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPSB2
  • Applied Biological Materials Clones for SPSB2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1: -
SP2: -

Relevant External Links for SPSB2 Gene

GeneLoc Exon Structure for
SPSB2
ECgene alternative splicing isoforms for
SPSB2

Expression for SPSB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPSB2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPSB2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPSB2 Gene:

SPSB2

SOURCE GeneReport for Unigene cluster for SPSB2 Gene:

Hs.479856

Evidence on tissue expression from TISSUES for SPSB2 Gene

  • Spleen(4)
genes like me logo Genes that share expression patterns with SPSB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPSB2 Gene

Orthologs for SPSB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPSB2 33
  • 98.99 (n)
dog
(Canis familiaris)
Mammalia SPSB2 34 33
  • 93.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia SPSB2 34 33
  • 91.18 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Spsb2 33 16 34
  • 87.2 (n)
zebrafish
(Danio rerio)
Actinopterygii SPSB2 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gus 34
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spsb-2 34
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8004 34
  • 40 (a)
OneToMany
Species where no ortholog for SPSB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPSB2 Gene

ENSEMBL:
Gene Tree for SPSB2 (if available)
TreeFam:
Gene Tree for SPSB2 (if available)

Paralogs for SPSB2 Gene

Paralogs for SPSB2 Gene

(3) SIMAP similar genes for SPSB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPSB2: view

Variants for SPSB2 Gene

Sequence variations from dbSNP and Humsavar for SPSB2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs144171030 Uncertain significance 6,870,561(+) GACCA(A/G)GCCAA downstream-variant-500B, utr-variant-3-prime
rs201871949 Uncertain significance 6,870,924(+) AAAAA(-/A)CAAGA downstream-variant-500B, utr-variant-3-prime
rs782061169 Uncertain significance 6,870,452(+) ACTGC(C/T)CTTTC downstream-variant-500B, utr-variant-3-prime
rs782764628 Uncertain significance 6,870,643(+) AAGGC(A/G)TGGTG downstream-variant-500B, utr-variant-3-prime
rs886049811 Uncertain significance 6,870,622(+) TTCTC(C/T)TTGGC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPSB2 Gene

Variant ID Type Subtype PubMed ID
esv3580405 CNV gain 25503493
nsv557261 CNV loss 21841781
nsv832324 CNV loss 17160897

Variation tolerance for SPSB2 Gene

Residual Variation Intolerance Score: 37.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.33; 81.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPSB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPSB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB2 Gene

Disorders for SPSB2 Gene

Relevant External Links for SPSB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPSB2

No disorders were found for SPSB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB2 Gene

Publications for SPSB2 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D … Wu G (The Journal of biological chemistry 2005) 3 4 22 60
  2. Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4. (PMID: 20561531) Filippakopoulos P … Bullock AN (Journal of molecular biology 2010) 3 4 60
  3. Structural and functional insights into the B30.2/SPRY domain. (PMID: 16498413) Woo JS … Oh BH (The EMBO journal 2006) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PMID: 15601820) Kamura T … Nakayama KI (Genes & development 2004) 3 4 60

Products for SPSB2 Gene

  • Addgene plasmids for SPSB2

Sources for SPSB2 Gene

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