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SPSB2 Gene

protein-coding   GIFtS: 50
GCID: GC12M006980

SplA/Ryanodine Receptor Domain And SOCS Box Containing 2

  Search for SPSB2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
SplA/Ryanodine Receptor Domain And SOCS Box Containing 21 2     SPRY Domain-Containing SOCS Box Protein 22
SSB22 3 5     SPRY Domain-Containing SOCS Box Protein SSB-22
Gene-Rich Cluster Protein C92 3     SSB-23
GRCC92 3     

External Ids:    HGNC: 295221   Entrez Gene: 847272   Ensembl: ENSG000001116717   OMIM: 6116585   UniProtKB: Q996193   
ORGUL members:         

Export aliases for SPSB2 gene to outside databases

Previous GC identifer: GC12M006851


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPSB2 Gene:
This gene encodes encodes a suppressor of cytokine signaling (SOCS) family member, and it belongs to the subfamily
of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. This gene is
present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate
isomerase genes. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2009)

GeneCards Summary for SPSB2 Gene:
SPSB2 (splA/ryanodine receptor domain and SOCS box containing 2) is a protein-coding gene. An important paralog of this gene is FBXO45.

UniProtKB/Swiss-Prot: SPSB2_HUMAN, Q99619
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPSB2 gene promoter:
         E2F-1   E2F   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPSB2 promoter sequence
   Search Chromatin IP Primers for SPSB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPSB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

SPSB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPSB2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M006980:  view genomic region     (about GC identifiers)

Start:
6,980,099 bp from pter      End:
6,998,522 bp from pter
Size:
18,424 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPSB2_HUMAN, Q99619 (See protein sequence)
Recommended Name: SPRY domain-containing SOCS box protein 2  
Size: 263 amino acids; 28630 Da
Subunit: Component of the probable ECS(SPSB2) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2,
Elongin BC complex and SPSB2. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with PAWR and MET
1 PDB 3D structure from and Proteopedia for SPSB2:
3EMW (3D)    
Secondary accessions: D3DUT0

Explore the universe of human proteins at neXtProt for SPSB2: NX_Q99619

Explore proteomics data for SPSB2 at MOPED


See SPSB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001139788.1  NP_116030.1  

ENSEMBL proteins: 
 ENSP00000430872   ENSP00000428338   ENSP00000431037   ENSP00000428458  
Reactome Protein details: Q99619

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Search eBioscience for ELISAs for SPSB2 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:
 IPR001870 B30.2/SPRY
 IPR003877 SPRY_rcpt
 IPR001496 SOCS_C
 IPR018355 SPla/RYanodine_receptor_subgr
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q99619

ProtoNet protein and cluster: Q99619

1 Blocks protein domain: IPB001496 SOCS protein

UniProtKB/Swiss-Prot: SPSB2_HUMAN, Q99619
Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
E3 ubiquitin ligase complexes (By similarity)
Similarity: Belongs to the SPSB family
Similarity: Contains 1 B30.2/SPRY domain
Similarity: Contains 1 SOCS box domain


Find genes that share domains with SPSB2           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: SPSB2_HUMAN, Q99619
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ND--
GO:0005515protein binding IPI15601820
     
Find genes that share ontologies with SPSB2           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SPSB2:
 Increased cell death HMECs cel 

     2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spsb2):
 hematopoietic system  homeostasis/metabolism 

Find genes that share phenotypes with SPSB2           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPSB2
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
SPSB2_HUMAN, Q99619: Cytoplasm (Probable)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005575cellular_component ND--
GO:0005737cytoplasm IEA--

Find genes that share ontologies with SPSB2           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SPSB2 About    
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84


Find genes that share SuperPaths with SPSB2           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for SPSB2
    Antigen processing: Ubiquitination & Proteasome degradation


UniProtKB/Swiss-Prot: SPSB2_HUMAN, Q99619
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Array including SPSB2: 

          Ubiquitin Ligases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for SPSB2

Selected Interacting proteins for SPSB2 (Q996191, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
TCEB1Q153691, 3EBI-2323209,EBI-301231 I2D: score=2 
CUL5Q930343I2D: score=1 
NOS2P352283I2D: score=1 
RNF7Q9UBF63I2D: score=1 
TCEB2Q153703I2D: score=1 
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--
GO:0016567protein ubiquitination IEA--
GO:0035556intracellular signal transduction IEA--

Find genes that share ontologies with SPSB2           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SPSB2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SPSB2 gene (3 alternative transcripts): 
NM_001146316.1  NM_032641.3  NM_001146317.1  

Unigene Cluster for SPSB2:

SplA/ryanodine receptor domain and SOCS box containing 2
Hs.479856  [show with all ESTs]
Unigene Representative Sequence: AK297963
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000523102(uc001qrl.3) ENST00000524270(uc001qrm.3) ENST00000519357
ENST00000432205 ENST00000437851
miRNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB2
Addgene plasmids for SPSB2 
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  QuantiFast Probe-based Assays in human, mouse, rat SPSB2

Additional mRNA sequence: 

AF403027.1 AK297963.1 BC002983.1 BC071933.1 

6 DOTS entries:

DT.65284346  DT.91933271  DT.91947326  DT.87016189  DT.97784464  DT.91684584 

Selected AceView cDNA sequences (see all 69):

AF403027 BC002983 AI241963 AI341418 NM_032641 CA426909 BX331561 AW043762 
BU632072 CB852191 AI635626 CD366415 AI377783 BM969281 BF684271 AW779948 
BE222853 BU500968 AI359227 BC071933 BQ710545 BM767960 BG403818 CB988188 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for SPSB2    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:        -                     
SP2:              -               


ECgene alternative splicing isoforms for SPSB2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SPSB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGCGCTACC
SPSB2 Expression
About this image

SPSB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SPSB2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.479856
    Pathway & Disease-focused RT2 Profiler PCR Array including SPSB2: 
          Ubiquitin Ligases in human mouse rat

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for SPSB2 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spsb21 , 5 splA/ryanodine receptor domain and SOCS box containing more1, 5 87.2(n)1
90.87(a)1
  6 (59.17 cM)5
147941  NM_013539.11  NP_038567.11 
 1248086615 
zebrafish
(Danio rerio)
Actinopterygii SPSB26
splA/ryanodine receptor domain and SOCS box contai...
39(a)
1 ↔ 1
23(44581024-44582288) ENSDARG00000088985
fruit fly
(Drosophila melanogaster)
Insecta gus6
gustavus
47(a)
1 → many
2R(1004495-1015816)
worm
(Caenorhabditis elegans)
Secernentea spsb-26
Protein SPSB-2 (spsb-2) mRNA, complete cds
44(a)
many ↔ many
II(15230362-15232802) WBGene00021596


ENSEMBL Gene Tree for SPSB2 (if available)
TreeFam Gene Tree for SPSB2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SPSB2 gene
FBXO452  SPSB12  SPSB42  
3 SIMAP similar genes for SPSB2 using alignment to 3 protein entries:     SPSB2_HUMAN (see all proteins):
SPSB4    FBXO45    SPSB1

Find genes that share paralogs with SPSB2           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SPSB2 (see all 86)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs110644371,2
C,F,A--6913596(+) GGGAGC/TTGGGA 2 -- int1 spa1 spl34Minor allele frequency- T:0.32WA CSA EA 242
rs110644381,2
C,F,A--6913611(+) AGGGGC/TGTGAA 2 -- int14Minor allele frequency- T:0.33WA CSA EA 242
rs1853120661,2
--6913645(+) GTCACC/TCAGGT 2 -- int10--------
rs64897391,2
C,F,A--6913781(+) GCCCCC/ATTTGG 2 -- int17Minor allele frequency- A:0.47NA WA CSA EA 366
rs110644391,2
C,F,H--6913839(+) GCCCCC/TGAACC 2 -- ut51 int112Minor allele frequency- T:0.09NS EA NA 1818
rs1453811411,2
C--6913844(+) CGAACA/CTCGGT 2 -- ut510--------
rs38253351,2
C,F--6913886(+) CTGAAG/AGAGCC 2 -- us2k1 ut518Minor allele frequency- A:0.27NA WA CSA EA 368
rs1122250891,2
C,F--6913956(+) CCTCCC/GTTGGG 2 -- us2k12Minor allele frequency- G:0.20NA 122
rs1142785861,2
C,F--6914065(+) GGGCCC/TCGCCC 2 -- us2k11Minor allele frequency- T:0.03WA 118
rs32134321,2
C,F--6914193(+) GAGGCC/TCCGCC 2 -- us2k1 tfbs31Minor allele frequency- T:0.18EA 120

HapMap Linkage Disequilibrium report for SPSB2 (6980099 - 6998522 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for SPSB2:    About this table    
Variant IDTypeSubtypePubMed ID
nsv898642CNV Loss21882294
nsv898641CNV Loss21882294
dgv1353n71CNV Loss21882294
nsv832324CNV Loss17160897

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for SPSB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611658    OMIM disorders: --


Find genes that share disorders with SPSB2           About GenesLikeMe


Export disorders for SPSB2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SPSB2 gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with SPSB2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2, 9 Wang D.... Wu G. (J. Biol. Chem. 2005)
  2. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (Genes Dev. 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
  5. Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PubMed id 9074930)1, 2 Ansari-Lari M.A.... Gibbs R.A. (Genome Res. 1997)
  6. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. (PubMed id 8723724)1, 3 Ansari-Lari M.A.... Gibbs R.A. (Genome Res. 1996)
  7. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
  8. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)
  9. The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase. (PubMed id 21549100)1 Matsumoto K....Miwa S. (Biochem. Biophys. Res. Commun. 2011)
  10. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84727 HGNC: 29522 AceView: GRCC9 Ensembl:ENSG00000111671 euGenes: HUgn84727
ECgene: SPSB2 H-InvDB: SPSB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SPSB2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SPSB2 gene:
Search GeneIP for patents involving SPSB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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