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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPSB1 Gene

protein-coding   GIFtS: 55
GCID: GC01P009352

splA/ryanodine receptor domain and SOCS box containing 1
 Explore 4 diseases affiliated with
SPSB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPSB1    

Aliases
for SPSB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SplA/Ryanodine Receptor Domain And SOCS Box Containing 11 2     SPRY Domain-Containing SOCS Box Protein 12
SSB-11 2 3     SPRY Domain-Containing SOCS Box Protein SSB-12
SSB12 3 5     SPSB5
Novel SPRY Domain Containing Protein2     

External Ids:    HGNC: 306281   Entrez Gene: 801762   Ensembl: ENSG000001716217   OMIM: 6116575   UniProtKB: Q96BD63   

Export aliases for SPSB1 gene to outside databases

Previous GC identifers: GC01P009288 GC01P008547


Summaries
for SPSB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
proteins

Gene Wiki entry for SPSB1


Genomic Views
for SPSB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_021937.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPSB1 gene promoter:
         C/EBPbeta   STAT1   AML1a   STAT1beta   GATA-1   STAT1alpha   Egr-2   S8   SEF-1 (1)   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SPSB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPSB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

SPSB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPSB1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P009352:  view genomic region     (about GC identifiers)

Start:
 9,352,939 bp from pter      End:
 9,429,591 bp from pter
Size:
 76,653 bases      Orientation:
 plus strand

Proteins
for SPSB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6 (See protein sequence)
Recommended Name: SPRY domain-containing SOCS box protein 1  
Size: 273 amino acids; 30942 Da
Subunit: Interacts with PARW (By similarity). Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex
which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Directly
interacts with MET tyrosine kinase domain in the presence and in the absence of HGF, however HGF treatment has a
positive effect on this interaction. When phosphorylated, interacts with RASA1 without affecting its stability
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=BAD92796.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for SPSB1:
2JK9 (3D)        3F2O (3D)    
Secondary accessions: A2A275 Q59FA1 Q5TIH9 Q9BRY9 Q9H6C5

Explore the universe of human proteins at neXtProt for SPSB1: NX_Q96BD6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96BD6

    • SPSB1 Protein expression data from MOPED and PaxDb:    About this image 
    SPSB1 Protein Expression
    REFSEQ proteins: NP_079382.2  
    ENSEMBL proteins: 
     ENSP00000330221   ENSP00000409235   ENSP00000350573   ENSP00000366616  
    Reactome Protein details: Q96BD6
    Human Recombinant Protein Products for SPSB1: 
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    Novus Biologicals SPSB1 Proteins
    Novus Biologicals SPSB1 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for SPSB1
    Uscn Proteins for SPSB1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SPSB1 for ontologies           About GeneDecksing



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    Assay Products for SPSB1: 
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    Uscn ELISAs and CLIAs for SPSB1

    Protein Domains /
    Families
    for SPSB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPSB1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001496 SOCS_C
     IPR018355 SPla/RYanodine_receptor_subgr
     IPR001870 B30.2/SPRY
     IPR008985 ConA-like_lec_gl_sf
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q96BD6

    ProtoNet protein and cluster: Q96BD6

    2 Blocks protein families:
    IPB001496 SOCS protein
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3
    ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding
    Similarity: Belongs to the SPSB family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 SOCS box domain


    Function
    for SPSB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPSB1_HUMAN, Q96BD6
    Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target
    proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity ----
         
    SPSB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPSB1:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Spsb1 (no phenotypes)

    SPSB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPSB1 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SPSB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPSB1
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SPSB1 (see all 35):
    hsa-miR-3130-5p hsa-miR-142-5p hsa-miR-218 hsa-miR-548m hsa-miR-186 hsa-miR-2113 hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: SPSB1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPSB1 (see all 7)
    OriGene shRNA RFP: SPSB1
    OriGene siRNA: SPSB1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against SPSB1 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPSB1
    Sirion Biotech Customized adenovirus for overexpression of SPSB1 
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPSB1 (see all 3)
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB1


    Pathways & Interactions
    for SPSB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SPSB1
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
    Pathway: Protein modification; protein ubiquitination


    SPSB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPSB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for SPSB1 (Q96BD63 ENSP000003302214) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF7Q9UBF63, ENSP000002734804I2D: score=2 STRING: ENSP00000273480
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    METP085813, ENSP000003172724I2D: score=1 STRING: ENSP00000317272
    NOS2P352283, ENSP000003272514I2D: score=1 STRING: ENSP00000327251
    RASA1P209363, ENSP000002743764I2D: score=1 STRING: ENSP00000274376
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    SPSB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPSB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPSB1
    Search CenterWatch for drugs/clinical trials and news about SPSB1 

    Transcripts
    for SPSB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPSB1 gene: 
    NM_025106.3  

    Unigene Clusters for SPSB1:

    SplA/ryanodine receptor domain and SOCS box containing 1
    Hs.8261  [show with all ESTs], Hs.738680
    Unigene Representative Sequences: NM_025106, AK130055
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328089(uc010oae.2 uc001apv.3) ENST00000450402 ENST00000357898
    ENST00000377399

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SPSB1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPSB1
    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SPSB1 (see all 35):
    hsa-miR-3130-5p hsa-miR-142-5p hsa-miR-218 hsa-miR-548m hsa-miR-186 hsa-miR-2113 hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: SPSB1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPSB1 (see all 7)
    OriGene shRNA RFP: SPSB1
    OriGene siRNA: SPSB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPSB1
    Sirion Biotech Custom design and validation of potent shRNA sequences against SPSB1 
    Clone
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    GenScript: all cDNA clones in your preferred vector: SPSB1 (NM_025106)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPSB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB1 
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPSB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPSB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB1

    Additional cDNA sequence: AK130055.1 

    4 DOTS entries:

    DT.215057  DT.75100553  DT.97825128  DT.95271498 

    24/127 AceView cDNA sequences (see all 127):

    BC005852 BM453728 CK904010 CR609804 AI467878 AF403026 AI001211 BU685023 
    CK904009 BM052812 BU736420 AI811517 BX118363 AI311394 BQ024925 AI915997 
    AA928482 AW664331 BX382164 AI695261 BM696217 BM023258 BU185168 NM_025106 

    GeneLoc Exon Structure


    Expression
    for SPSB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPSB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    SPSB1 Expression
    About this image

    SPSB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPSB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPSB1

    SOURCE GeneReport for Unigene clusters: Hs.8261 Hs.738680
        SABiosciences Expression via Pathway-Focused PCR Array including SPSB1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for SPSB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPSB1 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPSB11 splA/ryanodine receptor domain and SOCS box containing more 80.95(n)
    95.6(a)    		   419441  XM_417599.3  XP_417599.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SPSB16
    		 --
    		 92(a)
    		 1 ↔ 1
    		 GL343701.1(182318-186057)
    African clawed frog
    (Xenopus laevis)    		 Amphibia nszf-e326-prov2 nszf-e326 74.76(n)    BC045223.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii spsb11 splA/ryanodine receptor domain and SOCS box containing more 74.24(n)
    87.18(a)    		   334190  NM_001025460.1  NP_001020631.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta gus6
    		 gustavus
    		 68(a)
    		 1 → many
    		 2R(1004495-1015816)
    worm
    (Caenorhabditis elegans)    		 Secernentea spsb-26
    spsb-16
    		 Protein SPSB-1
    		 49(a)
    26(a)
    		 many ↔ many
    many ↔ many
    		 II(15230286-15232726)
    II(15207367-15226652)


    ENSEMBL Gene Tree for SPSB1 (if available)
    TreeFam Gene Tree for SPSB1 (if available) 

    Paralogs
    for SPSB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPSB1 gene
    SPSB22  FBXO452  SPSB42  
    3 SIMAP similar genes for SPSB1 using alignment to 2 protein entries:     SPSB1_HUMAN (see all proteins):
    SPSB4    SPSB2    FBXO45

    SPSB1 for paralogs           About GeneDecksing



    Genomic Variants
    for SPSB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1701 NCBI SNPs in SPSB1 are shown (see all 1701)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs57723641,2
    		C--9351018(+) TTTTCT/-TTTTT 1 -- us2k1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1406772631,2
    		--9351030(+) TTGAGA/GTGGAG 1 -- us2k10--------
    rs1457748191,2
    		--9351040(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1384962701,2
    		--9351075(+) GCGATA/GTCGGC 1 -- us2k10--------
    rs1916416611,2
    		--9351133(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs1420047961,2
    		--9351155(+) AGGCAC/TGTACC 1 -- us2k10--------
    rs2004617201,2
    		--9351231(+) CTGAA-/CTTCTTCT 1 -- us2k10--------
    rs1841586191,2
    		--9351268(+) GAGACA/GGAGTC 1 -- us2k10--------
    rs1884431831,2
    		--9351276(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1501004981,2
    		--9351306(+) GTGGCA/GCAATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPSB1 (9352939 - 9429591 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for SPSB1
         6 CNVs: 48377 53758 8317 8316 34418 48378
    Locus Specific Mutation Databases (LSDB): SPSB1

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    Disorders / Diseases
    for SPSB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPSB1 for disorders           About GeneDecksing

    OMIM gene information: 611657    OMIM disorders: --

    4 diseases for SPSB1:    About MalaCards
    refractive error    primary hyperparathyroidism    hyperparathyroidism    keratoconus

    1 disease from the University of Copenhagen DISEASES database for SPSB1:
    Keratoconus
    Human Genome Epidemiology (HuGE) Navigator: SPSB1 (1 document)

    Export disorders for SPSB1 gene to outside databases

    Publications
    for SPSB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPSB1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SPSB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2, 3, 9 Wang D....Wu G. (2005)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
    6. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1 Wang J....Platt A. (2012)
    7. A genome-wide association study of host genetic determ inants of the antibody response to Anthrax Vaccine Adsorbed. (PubMed id 22658931)1 Pajewski N.M....Kaslow R.A. (2012)
    8. The ECS(SPSB) E3 ubiquitin ligase is the master regul ator of the lifetime of inducible nitric-oxide synthase. (PubMed id 21549100)1 Matsumoto K....Miwa S. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. (PubMed id 21199876)1 Nishiya T....Miwa S. (2011)

    External Searches for SPSB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SPSB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80176 HGNC: 30628 AceView: SSB1 Ensembl:ENSG00000171621 euGenes: HUgn80176
    ECgene: SPSB1 H-InvDB: SPSB1

    Other Databases showing SPSB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPSB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPSB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPSB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPSB1 gene:
    Search GeneIP for patents involving SPSB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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