Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPSB1 Gene

Aliases for SPSB1 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 1 2 3
  • SSB1 3 4 6
  • SSB-1 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-1 3
  • SPRY Domain-Containing SOCS Box Protein 1 3
  • Novel SPRY Domain Containing Protein 3
  • SPSB 6

External Ids for SPSB1 Gene

Summaries for SPSB1 Gene

GeneCards Summary for SPSB1 Gene

SPSB1 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot for SPSB1 Gene

  • Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for SPSB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB1 Gene

Genomics for SPSB1 Gene

Genomic Location for SPSB1 Gene

Start:
9,292,880 bp from pter
End:
9,369,532 bp from pter
Size:
76,653 bases
Orientation:
Plus strand

Genomic View for SPSB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPSB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB1 Gene

Regulatory Elements for SPSB1 Gene

Proteins for SPSB1 Gene

  • Protein details for SPSB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BD6-SPSB1_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 1
    Protein Accession:
    Q96BD6
    Secondary Accessions:
    • A2A275
    • Q59FA1
    • Q5TIH9
    • Q9BRY9
    • Q9H6C5

    Protein attributes for SPSB1 Gene

    Size:
    273 amino acids
    Molecular mass:
    30942 Da
    Quaternary structure:
    • Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Directly interacts with MET tyrosine kinase domain in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. When phosphorylated, interacts with RASA1 without affecting its stability. Interacts, in complex with Elongin BC complex, with PAWR.
    SequenceCaution:
    • Sequence=BAD92796.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPSB1 Gene

neXtProt entry for SPSB1 Gene

Proteomics data for SPSB1 Gene at MOPED

Post-translational modifications for SPSB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPSB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SPSB1 Gene

Domains for SPSB1 Gene

UniProtKB/Swiss-Prot:

SPSB1_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding.:
    • Q96BD6
  • Contains 1 B30.2/SPRY domain.:
    • Q96BD6
  • Contains 1 SOCS box domain.:
    • Q96BD6
Family:
  • Belongs to the SPSB family.:
    • Q96BD6
genes like me logo Genes that share domains with SPSB1: view

No data available for Gene Families for SPSB1 Gene

Function for SPSB1 Gene

Molecular function for SPSB1 Gene

UniProtKB/Swiss-Prot Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for SPSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20561531
genes like me logo Genes that share ontologies with SPSB1: view

Phenotypes for SPSB1 Gene

GenomeRNAi human phenotypes for SPSB1:
genes like me logo Genes that share phenotypes with SPSB1: view

miRNA for SPSB1 Gene

miRTarBase miRNAs that target SPSB1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPSB1 Gene

Localization for SPSB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPSB1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPSB1 Gene COMPARTMENTS Subcellular localization image for SPSB1 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPSB1: view

Pathways for SPSB1 Gene

genes like me logo Genes that share pathways with SPSB1: view

UniProtKB/Swiss-Prot Q96BD6-SPSB1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for SPSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with SPSB1: view

Transcripts for SPSB1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB1 Gene

No ASD Table

Relevant External Links for SPSB1 Gene

GeneLoc Exon Structure for
SPSB1
ECgene alternative splicing isoforms for
SPSB1

Expression for SPSB1 Gene

mRNA expression in normal human tissues for SPSB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPSB1 Gene

SOURCE GeneReport for Unigene cluster for SPSB1 Gene Hs.8261

genes like me logo Genes that share expressions with SPSB1: view

Orthologs for SPSB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPSB1 36
  • 99.39 (n)
  • 99.63 (a)
SPSB1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPSB1 36
  • 91.45 (n)
  • 98.9 (a)
SPSB1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPSB1 36
  • 91.45 (n)
  • 98.9 (a)
SPSB1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spsb1 36
  • 88.64 (n)
  • 98.53 (a)
Spsb1 16
Spsb1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPSB1 37
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPSB1 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spsb1 36
  • 88.16 (n)
  • 98.17 (a)
chicken
(Gallus gallus)
Aves SPSB1 36
  • 80.95 (n)
  • 95.6 (a)
SPSB1 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPSB1 37
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nszf-e326-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia spsb1 36
  • 75.09 (n)
  • 89.74 (a)
Str.16969 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7541 36
zebrafish
(Danio rerio)
Actinopterygii spsb1 36
  • 74.24 (n)
  • 87.18 (a)
spsb1 37
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gus 37
  • 70 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8004 37
  • 48 (a)
OneToMany
Species with no ortholog for SPSB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPSB1 Gene

ENSEMBL:
Gene Tree for SPSB1 (if available)
TreeFam:
Gene Tree for SPSB1 (if available)

Paralogs for SPSB1 Gene

Paralogs for SPSB1 Gene

Selected SIMAP similar genes for SPSB1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPSB1: view

Variants for SPSB1 Gene

Sequence variations from dbSNP and Humsavar for SPSB1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs473654 -- 9,351,608(-) CACCT(C/T)CCCTG intron-variant
rs478103 -- 9,342,344(+) GAAAC(C/T)GTGTG intron-variant
rs478552 -- 9,298,420(+) tgaat(A/G)agtga intron-variant
rs479043 -- 9,342,461(+) GCTTG(G/T)CAATT intron-variant
rs482215 -- 9,347,904(-) ACACT(C/T)CTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPSB1 Gene

Variant ID Type Subtype PubMed ID
nsv832092 CNV Loss 17160897
dgv2e55 CNV Gain 17911159
dgv131n71 CNV Gain 21882294
dgv3n27 CNV Gain 19166990
nsv520191 CNV Gain 19592680
esv2750845 CNV Gain 17911159
nsv870719 CNV Gain 21882294
esv2743574 CNV Deletion 23290073
esv2743586 CNV Deletion 23290073
esv2201511 CNV Deletion 18987734
esv1000068 CNV Insertion 20482838
dgv132n71 CNV Loss 21882294
nsv871098 CNV Loss 21882294
nsv464172 CNV Loss 19166990

Relevant External Links for SPSB1 Gene

HapMap Linkage Disequilibrium report
SPSB1
Locus Specific Mutation Databases (LSDB)
SPSB1

Disorders for SPSB1 Gene

(1) University of Copenhagen DISEASES for SPSB1 Gene

Relevant External Links for SPSB1

Genetic Association Database (GAD)
SPSB1
Human Genome Epidemiology (HuGE) Navigator
SPSB1
genes like me logo Genes that share disorders with SPSB1: view

No data available for UniProtKB/Swiss-Prot for SPSB1 Gene

Publications for SPSB1 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 2 3 4 23
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. Structural basis for protein recognition by B30.2/SPRY domains. (PMID: 17189197) Woo J.S. … Oh B.H. (Mol. Cell 2006) 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SPSB1 Gene

Sources for SPSB1 Gene

Back to Top

Content