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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPSB1 Gene

protein-coding   GIFtS: 54
GCID: GC01P009352

SplA/Ryanodine Receptor Domain And SOCS Box Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SplA/Ryanodine Receptor Domain And SOCS Box Containing 11 2     SPRY Domain-Containing SOCS Box Protein 12
SSB12 3 5     SPRY Domain-Containing SOCS Box Protein SSB-12
SSB-12 3     SPSB5
Novel SPRY Domain Containing Protein2     

External Ids:    HGNC: 306281   Entrez Gene: 801762   Ensembl: ENSG000001716217   OMIM: 6116575   UniProtKB: Q96BD63   

Export aliases for SPSB1 gene to outside databases

Previous GC identifers: GC01P009288 GC01P008547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPSB1 Gene: 
SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) is a protein-coding gene. Diseases associated with SPSB1 include refractive error, and primary hyperparathyroidism, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins

Gene Wiki entry for SPSB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPSB1 gene promoter:
         C/EBPbeta   STAT1   AML1a   STAT1beta   GATA-1   STAT1alpha   Egr-2   S8   SEF-1 (1)   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SPSB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPSB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

SPSB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPSB1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P009352:  view genomic region     (about GC identifiers)

Start:
9,352,939 bp from pter      End:
9,429,591 bp from pter
Size:
76,653 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6 (See protein sequence)
Recommended Name: SPRY domain-containing SOCS box protein 1  
Size: 273 amino acids; 30942 Da
Subunit: Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2,
Elongin BC complex and SPSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Directly interacts with MET tyrosine
kinase domain in the presence and in the absence of HGF, however HGF treatment has a positive effect on this
interaction. When phosphorylated, interacts with RASA1 without affecting its stability. Interacts, in complex
with Elongin BC complex, with PAWR
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=BAD92796.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for SPSB1:
2JK9 (3D)        3F2O (3D)    
Secondary accessions: A2A275 Q59FA1 Q5TIH9 Q9BRY9 Q9H6C5

Explore the universe of human proteins at neXtProt for SPSB1: NX_Q96BD6

Explore proteomics data for SPSB1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96BD6

  • SPSB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPSB1 Protein Expression
    REFSEQ proteins: NP_079382.2  
    ENSEMBL proteins: 
     ENSP00000330221   ENSP00000409235   ENSP00000350573   ENSP00000366616  
    Reactome Protein details: Q96BD6
    Human Recombinant Protein Products for SPSB1: 
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    Novus Biologicals SPSB1 Proteins
    Novus Biologicals SPSB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for SPSB1
    Cloud-Clone Corp. Proteins for SPSB1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SPSB1 for ontologies           About GeneDecksing



    SPSB1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SPSB1 

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    Cloud-Clone Corp. ELISAs for SPSB1 
    Cloud-Clone Corp. CLIAs for SPSB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR001496 SOCS_C
     IPR018355 SPla/RYanodine_receptor_subgr
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q96BD6

    ProtoNet protein and cluster: Q96BD6

    2 Blocks protein domains:
    IPB001496 SOCS protein
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding
    Similarity: Belongs to the SPSB family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 SOCS box domain


    SPSB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPSB1_HUMAN, Q96BD6
    Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    SPSB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPSB1:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Spsb1 (no phenotypes)

    SPSB1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPSB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPSB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPSB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPSB1 

    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SPSB1 (see all 35):
    hsa-miR-3130-5p hsa-miR-142-5p hsa-miR-218 hsa-miR-548m hsa-miR-186 hsa-miR-2113 hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidSPSB1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPSB1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SPSB1
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
    Pathway: Protein modification; protein ubiquitination


    SPSB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPSB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for SPSB1 (Q96BD63 ENSP000003302214) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF7Q9UBF63, ENSP000002734804I2D: score=2 STRING: ENSP00000273480
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    METP085813, ENSP000003172724I2D: score=1 STRING: ENSP00000317272
    NOS2P352283, ENSP000003272514I2D: score=1 STRING: ENSP00000327251
    RASA1P209363, ENSP000002743764I2D: score=1 STRING: ENSP00000274376
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    SPSB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPSB1

    Search CenterWatch for drugs/clinical trials and news about SPSB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPSB1 gene: 
    NM_025106.3  

    Unigene Clusters for SPSB1:

    SplA/ryanodine receptor domain and SOCS box containing 1
    Hs.8261  [show with all ESTs], Hs.738680
    Unigene Representative Sequences: NM_025106, AK130055
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328089(uc010oae.2 uc001apv.3) ENST00000450402 ENST00000357898
    ENST00000377399
    miRNA
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    8/35 QIAGEN miScript miRNA Assays for microRNAs that regulate SPSB1 (see all 35):
    hsa-miR-3130-5p hsa-miR-142-5p hsa-miR-218 hsa-miR-548m hsa-miR-186 hsa-miR-2113 hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidSPSB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPSB1
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    GenScript: all cDNA clones in your preferred vector: SPSB1 (NM_025106)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPSB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPSB1
    Sirion Biotech Customized lentivirus for stable overexpression of SPSB1 
                         Customized lentivirus expression plasmids for stable overexpression of SPSB1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPSB1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPSB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB1

    Additional mRNA sequence: AK130055.1 

    4 DOTS entries:

    DT.215057  DT.75100553  DT.97825128  DT.95271498 

    24/127 AceView cDNA sequences (see all 127):

    BU685023 AW664331 AA928482 CK904010 BX118363 AI467878 CR609804 AF403026 
    BM052812 BM453728 BU736420 CK904009 BC005852 AI001211 AI915997 AI811517 
    BQ024925 AI311394 BQ683818 BU180110 AK026046 AA622644 BE858838 AI278218 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPSB1 expression in normal human tissues (normalized intensities)      SPSB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPSB1 Expression
    About this image


    SPSB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Breast (Uncategorized)
             breast stroma   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             cd49a+ cells   
     
     Dermis (Integumentary System)
             Guard Dermal Papilla Cells Dermal Papilla
     
     Testis (Reproductive System)

    See SPSB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPSB1

    SOURCE GeneReport for Unigene clusters: Hs.8261 Hs.738680
        SABiosciences Expression via Pathway-Focused PCR Array including SPSB1: 
              Ubiquitin Ligases in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPSB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPSB1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spsb11 , 5 splA/ryanodine receptor domain and SOCS box containing more1, 5 88.64(n)1
    98.53(a)1
      4 (80.46 cM)5
    746461  NM_029035.21  NP_083311.11 
     1498962835 
    chicken
    (Gallus gallus)
    Aves SPSB11 splA/ryanodine receptor domain and SOCS box containing more 80.95(n)
    95.6(a)
      419441  XM_417599.3  XP_417599.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPSB16
    Uncharacterized protein
    92(a)
    1 ↔ 1
    GL343701.1(166589-187761)
    African clawed frog
    (Xenopus laevis)
    Amphibia nszf-e326-prov2 nszf-e326 74.76(n)    BC045223.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spsb11 splA/ryanodine receptor domain and SOCS box containing more 74.24(n)
    87.18(a)
      334190  NM_001025460.1  NP_001020631.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gus6
    gustavus
    70(a)
    1 → many
    2R(1004495-1015816)
    worm
    (Caenorhabditis elegans)
    Secernentea spsb-26
    spsb-16
    Protein SPSB-1
    48(a)
    25(a)
    possible ortholog
    possible ortholog
    II(15230362-15232802)
    II(15207443-15226728)


    ENSEMBL Gene Tree for SPSB1 (if available)
    TreeFam Gene Tree for SPSB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPSB1 gene
    SPSB22  FBXO452  SPSB42  
    3 SIMAP similar genes for SPSB1 using alignment to 2 protein entries:     SPSB1_HUMAN (see all proteins):
    SPSB4    SPSB2    FBXO45

    SPSB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1980 SNPs in SPSB1 are shown (see all 1980)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57723641,2
    C--9351018(+) TTTTCT/-TTTTT 1 -- us2k1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1406772631,2
    C--9351030(+) TTGAGA/GTGGAG 1 -- us2k10--------
    rs1457748191,2
    --9351040(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1384962701,2
    C--9351075(+) GCGATA/GTCGGC 1 -- us2k10--------
    rs1916416611,2
    --9351133(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs1420047961,2
    --9351155(+) AGGCAC/TGTACC 1 -- us2k10--------
    rs2004617201,2
    C--9351231(+) CTGAA-/CTTCTTCT 1 -- cds10--------
    rs1841586191,2
    C--9351268(+) GAGACA/GGAGTC 1 -- us2k10--------
    rs1884431831,2
    C--9351276(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1501004981,2
    --9351306(+) GTGGCA/GCAATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPSB1 (9352939 - 9429591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for SPSB1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2743574CNV Deletion23290073
    esv2743586CNV Deletion23290073
    esv2201511CNV Deletion18987734
    esv1000068CNV Insertion20482838
    nsv871098CNV Loss21882294
    nsv464172CNV Loss19166990
    dgv132n71CNV Loss21882294
    nsv832092CNV Loss17160897
    esv2750845CNV Gain17911159
    dgv3n27CNV Gain19166990


    Locus Specific Mutation Databases (LSDB): SPSB1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611657    OMIM disorders: --

    6 diseases for SPSB1:    About MalaCards
    refractive error    primary hyperparathyroidism    hyperparathyroidism    keratoconus
    rheumatoid arthritis    arthritis

    1 disease from the University of Copenhagen DISEASES database for SPSB1:
    Keratoconus

    SPSB1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPSB1
    Human Genome Epidemiology (HuGE) Navigator: SPSB1 (1 document)

    Export disorders for SPSB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPSB1 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with SPSB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2, 3, 9 Wang D....Wu G. (2005)
    2. Genome-wide association analysis implicates the involv ement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (2002)
    9. Structural basis for protein recognition by B30.2/SPRY domains. (PubMed id 17189197)2, 9 Woo J.S....Oh B.H. (2006)
    10. GWAS of dental caries patterns in the permanent dentit ion. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80176 HGNC: 30628 AceView: SSB1 Ensembl:ENSG00000171621 euGenes: HUgn80176
    ECgene: SPSB1 H-InvDB: SPSB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPSB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPSB1 gene:
    Search GeneIP for patents involving SPSB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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