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Aliases for SPSB1 Gene

Aliases for SPSB1 Gene

  • SplA/Ryanodine Receptor Domain And SOCS Box Containing 1 2 3 5
  • SSB-1 3 4
  • SSB1 3 4
  • SPRY Domain-Containing SOCS Box Protein SSB-1 3
  • Novel SPRY Domain Containing Protein 3

External Ids for SPSB1 Gene

Previous GeneCards Identifiers for SPSB1 Gene

  • GC01P009288
  • GC01P008547

Summaries for SPSB1 Gene

GeneCards Summary for SPSB1 Gene

SPSB1 (SplA/Ryanodine Receptor Domain And SOCS Box Containing 1) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot for SPSB1 Gene

  • Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for SPSB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPSB1 Gene

Genomics for SPSB1 Gene

Regulatory Elements for SPSB1 Gene

Promoters for SPSB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPSB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPSB1 Gene

Chromosome:
1
Start:
9,292,880 bp from pter
End:
9,369,532 bp from pter
Size:
76,653 bases
Orientation:
Plus strand

Genomic View for SPSB1 Gene

Genes around SPSB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPSB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPSB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPSB1 Gene

Proteins for SPSB1 Gene

  • Protein details for SPSB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BD6-SPSB1_HUMAN
    Recommended name:
    SPRY domain-containing SOCS box protein 1
    Protein Accession:
    Q96BD6
    Secondary Accessions:
    • A2A275
    • Q59FA1
    • Q5TIH9
    • Q9BRY9
    • Q9H6C5

    Protein attributes for SPSB1 Gene

    Size:
    273 amino acids
    Molecular mass:
    30942 Da
    Quaternary structure:
    • Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SPSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Directly interacts with MET tyrosine kinase domain in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. When phosphorylated, interacts with RASA1 without affecting its stability. Interacts, in complex with Elongin BC complex, with PAWR.
    SequenceCaution:
    • Sequence=BAD92796.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPSB1 Gene

neXtProt entry for SPSB1 Gene

Proteomics data for SPSB1 Gene at MOPED

Post-translational modifications for SPSB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPSB1 Gene

Antibody Products

No data available for DME Specific Peptides for SPSB1 Gene

Domains & Families for SPSB1 Gene

Suggested Antigen Peptide Sequences for SPSB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BD6

UniProtKB/Swiss-Prot:

SPSB1_HUMAN :
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding.
  • Belongs to the SPSB family.
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 SOCS box domain.
Family:
  • Belongs to the SPSB family.
genes like me logo Genes that share domains with SPSB1: view

No data available for Gene Families for SPSB1 Gene

Function for SPSB1 Gene

Molecular function for SPSB1 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for SPSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
genes like me logo Genes that share ontologies with SPSB1: view
genes like me logo Genes that share phenotypes with SPSB1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPSB1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPSB1 Gene

Localization for SPSB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPSB1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPSB1 Gene COMPARTMENTS Subcellular localization image for SPSB1 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for SPSB1 Gene

Pathways & Interactions for SPSB1 Gene

genes like me logo Genes that share pathways with SPSB1: view

UniProtKB/Swiss-Prot Q96BD6-SPSB1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPSB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
genes like me logo Genes that share ontologies with SPSB1: view

No data available for SIGNOR curated interactions for SPSB1 Gene

Drugs & Compounds for SPSB1 Gene

No Compound Related Data Available

Transcripts for SPSB1 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPSB1 Gene

No ASD Table

Relevant External Links for SPSB1 Gene

GeneLoc Exon Structure for
SPSB1
ECgene alternative splicing isoforms for
SPSB1

Expression for SPSB1 Gene

mRNA expression in normal human tissues for SPSB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPSB1 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPSB1 Gene



SOURCE GeneReport for Unigene cluster for SPSB1 Gene Hs.8261

genes like me logo Genes that share expression patterns with SPSB1: view

Protein tissue co-expression partners for SPSB1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPSB1 Gene

Orthologs for SPSB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPSB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPSB1 36
  • 100 (a)
OneToOne
SPSB1 35
  • 99.39 (n)
  • 99.63 (a)
cow
(Bos Taurus)
Mammalia SPSB1 36
  • 99 (a)
OneToOne
SPSB1 35
  • 91.45 (n)
  • 98.9 (a)
dog
(Canis familiaris)
Mammalia SPSB1 35
  • 91.45 (n)
  • 98.9 (a)
SPSB1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spsb1 16
Spsb1 35
  • 88.64 (n)
  • 98.53 (a)
Spsb1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPSB1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPSB1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spsb1 35
  • 88.16 (n)
  • 98.17 (a)
chicken
(Gallus gallus)
Aves SPSB1 35
  • 80.95 (n)
  • 95.6 (a)
SPSB1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPSB1 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia nszf-e326-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia spsb1 35
  • 75.09 (n)
  • 89.74 (a)
Str.16969 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7541 35
zebrafish
(Danio rerio)
Actinopterygii spsb1 36
  • 87 (a)
OneToOne
spsb1 35
  • 74.24 (n)
  • 87.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta gus 36
  • 70 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8004 36
  • 48 (a)
OneToMany
Species with no ortholog for SPSB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPSB1 Gene

ENSEMBL:
Gene Tree for SPSB1 (if available)
TreeFam:
Gene Tree for SPSB1 (if available)

Paralogs for SPSB1 Gene

Paralogs for SPSB1 Gene

(3) SIMAP similar genes for SPSB1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPSB1: view

Variants for SPSB1 Gene

Sequence variations from dbSNP and Humsavar for SPSB1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs478103 -- 9,342,344(+) GAAAC(C/T)GTGTG intron-variant
rs482215 -- 9,347,904(-) ACACT(C/T)CTACA intron-variant
rs483934 -- 9,347,744(-) ATAGG(C/T)CTGCA intron-variant
rs483936 -- 9,347,741(-) GGCCT(C/G)CACAG intron-variant
rs507656 -- 9,318,653(-) CACAC(C/G)GTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPSB1 Gene

Variant ID Type Subtype PubMed ID
nsv832092 CNV Loss 17160897
dgv2e55 CNV Gain 17911159
dgv131n71 CNV Gain 21882294
dgv3n27 CNV Gain 19166990
nsv520191 CNV Gain 19592680
esv2750845 CNV Gain 17911159
nsv870719 CNV Gain 21882294
esv2743574 CNV Deletion 23290073
esv2743586 CNV Deletion 23290073
esv2201511 CNV Deletion 18987734
esv1000068 CNV Insertion 20482838
dgv132n71 CNV Loss 21882294
nsv871098 CNV Loss 21882294
nsv464172 CNV Loss 19166990

Variation tolerance for SPSB1 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPSB1 Gene

HapMap Linkage Disequilibrium report
SPSB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPSB1 Gene

Disorders for SPSB1 Gene

Relevant External Links for SPSB1

Genetic Association Database (GAD)
SPSB1
Human Genome Epidemiology (HuGE) Navigator
SPSB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPSB1

No disorders were found for SPSB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPSB1 Gene

Publications for SPSB1 Gene

  1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PMID: 15713673) Wang D. … Wu G. (J. Biol. Chem. 2005) 2 3 4 23 67
  2. The SOCS box: a tale of destruction and degradation. (PMID: 12076535) Kile B.T. … Hilton D.J. (Trends Biochem. Sci. 2002) 2 3
  3. SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-I^ Signaling Pathway Targeting the Type II Receptor. (PMID: 26032413) Liu S. … Zhu H.J. (J. Biol. Chem. 2015) 3
  4. PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. (PMID: 25203322) Zheng H. … Kang Y. (Cancer Cell 2014) 3
  5. SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling. (PMID: 24786206) Feng Y. … Chodosh L.A. (Cancer Discov 2014) 3

Products for SPSB1 Gene

Sources for SPSB1 Gene

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