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SPSB1 Gene

protein-coding   GIFtS: 55
GCID: GC01P009352

SplA/Ryanodine Receptor Domain And SOCS Box Containing 1

  Search for SPSB1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SplA/Ryanodine Receptor Domain And SOCS Box Containing 11 2     SPRY Domain-Containing SOCS Box Protein 12
SSB12 3 5     SPRY Domain-Containing SOCS Box Protein SSB-12
SSB-12 3     SPSB5
Novel SPRY Domain Containing Protein2     

External Ids:    HGNC: 306281   Entrez Gene: 801762   Ensembl: ENSG000001716217   OMIM: 6116575   UniProtKB: Q96BD63   

Export aliases for SPSB1 gene to outside databases

Previous GC identifers: GC01P009288 GC01P008547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPSB1 Gene:
SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1) is a protein-coding gene. An important paralog of this gene is SPSB2.

UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
target proteins

Gene Wiki entry for SPSB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPSB1 gene promoter:
         C/EBPbeta   STAT1   AML1a   STAT1beta   GATA-1   STAT1alpha   Egr-2   S8   SEF-1 (1)   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SPSB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPSB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.22   Ensembl cytogenetic band:  1p36.22   HGNC cytogenetic band: 1p36.22

SPSB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPSB1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P009352:  view genomic region     (about GC identifiers)

Start:
9,352,939 bp from pter      End:
9,429,591 bp from pter
Size:
76,653 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6 (See protein sequence)
Recommended Name: SPRY domain-containing SOCS box protein 1  
Size: 273 amino acids; 30942 Da
Subunit: Component of the probable ECS(SPSB1) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2,
Elongin BC complex and SPSB1. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Directly interacts with MET tyrosine
kinase domain in the presence and in the absence of HGF, however HGF treatment has a positive effect on this
interaction. When phosphorylated, interacts with RASA1 without affecting its stability. Interacts, in complex
with Elongin BC complex, with PAWR
Sequence caution: Sequence=BAD92796.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for SPSB1:
2JK9 (3D)        3F2O (3D)    
Secondary accessions: A2A275 Q59FA1 Q5TIH9 Q9BRY9 Q9H6C5

Explore the universe of human proteins at neXtProt for SPSB1: NX_Q96BD6

Explore proteomics data for SPSB1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPSB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_079382.2  
    ENSEMBL proteins: 
     ENSP00000330221   ENSP00000409235   ENSP00000350573   ENSP00000366616  
    Reactome Protein details: Q96BD6

    SPSB1 Human Recombinant Protein Products:

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    Novus Biologicals SPSB1 Proteins
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    ProSpec Recombinant Protein for SPSB1
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    LSBio Antibodies in human, mouse, rat for SPSB1

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    Search eBioscience for ELISAs for SPSB1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR001496 SOCS_C
     IPR018355 SPla/RYanodine_receptor_subgr
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q96BD6

    ProtoNet protein and cluster: Q96BD6

    2 Blocks protein domains:
    IPB001496 SOCS protein
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
    Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different
    E3 ubiquitin ligase complexes (By similarity). The B30.2/SPRY domain is involved in MET binding
    Similarity: Belongs to the SPSB family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 SOCS box domain


    Find genes that share domains with SPSB1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPSB1_HUMAN, Q96BD6
    Function: Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3
    ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of
    target proteins

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with SPSB1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPSB1:
     Increased cell death HMECs cel 

         1 MGI phenotypic allele for Spsb1 (no phenotypes)

    Find genes that share phenotypes with SPSB1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPSB1
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    miRNA
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    miRTarBase miRNAs that target SPSB1:
    hsa-mir-335-5p (MIRT017474)

    Block miRNA regulation of human, mouse, rat SPSB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPSB1 (see all 35):
    hsa-miR-3130-5p hsa-miR-142-5p hsa-miR-218 hsa-miR-548m hsa-miR-186 hsa-miR-2113 hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidSPSB1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SPSB1

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    Addgene plasmids for SPSB1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPSB1_HUMAN, Q96BD6: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with SPSB1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPSB1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with SPSB1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SPSB1
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: SPSB1_HUMAN, Q96BD6
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including SPSB1: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SPSB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for SPSB1 (Q96BD61, 3 ENSP000003302214) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF7Q9UBF63, ENSP000002734804I2D: score=2 STRING: ENSP00000273480
    TCEB2Q153703, ENSP000002623064I2D: score=2 STRING: ENSP00000262306
    METP085813, ENSP000003172724I2D: score=1 STRING: ENSP00000317272
    NOS2P352283, ENSP000003272514I2D: score=1 STRING: ENSP00000327251
    RASA1P209363, ENSP000002743764I2D: score=1 STRING: ENSP00000274376
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0035556intracellular signal transduction IEA--

    Find genes that share ontologies with SPSB1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPSB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPSB1 gene: 
    NM_025106.3  

    Unigene Cluster for SPSB1:

    SplA/ryanodine receptor domain and SOCS box containing 1
    Hs.8261  [show with all ESTs]
    Unigene Representative Sequence: NM_025106
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328089(uc010oae.2 uc001apv.3) ENST00000450402 ENST00000357898
    ENST00000377399
    miRNA
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    Block miRNA regulation of human, mouse, rat SPSB1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPSB1 (see all 35):
    hsa-miR-3130-5p hsa-miR-142-5p hsa-miR-218 hsa-miR-548m hsa-miR-186 hsa-miR-2113 hsa-miR-3163 hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmidSPSB1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SPSB1
      QuantiFast Probe-based Assays in human, mouse, rat SPSB1

    Additional mRNA sequence: 

    AB209559.1 AF131840.1 AF403026.1 AK026046.1 AK225417.1 BC005852.2 BC015711.1 

    4 DOTS entries:

    DT.215057  DT.75100553  DT.97825128  DT.95271498 

    Selected AceView cDNA sequences (see all 127):

    AF403026 BC005852 AW664331 BM052812 BU685023 CK904010 BX118363 AI811517 
    AI915997 CK904009 AI311394 AA928482 AI467878 BQ024925 BU736420 BM453728 
    AI001211 CR609804 AI090187 BX382164 BX367079 AF131840 H98713 AW138820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPSB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPSB1 Expression
    About this image


    SPSB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Testis (Reproductive System)
    SPSB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPSB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.8261
        Pathway & Disease-focused RT2 Profiler PCR Array including SPSB1: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPSB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPSB1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spsb11 , 5 splA/ryanodine receptor domain and SOCS box containing more1, 5 88.64(n)1
    98.53(a)1
      4 (80.46 cM)5
    746461  NM_029035.21  NP_083311.11 
     1498962835 
    chicken
    (Gallus gallus)
    Aves SPSB11 splA/ryanodine receptor domain and SOCS box containing more 80.95(n)
    95.6(a)
      419441  XM_417599.4  XP_417599.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPSB16
    splA/ryanodine receptor domain and SOCS box contai...
    92(a)
    1 ↔ 1
    GL343701.1(166589-187761)
    African clawed frog
    (Xenopus laevis)
    Amphibia nszf-e326-prov2 nszf-e326 74.76(n)    BC045223.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spsb11 splA/ryanodine receptor domain and SOCS box containing more 74.24(n)
    87.18(a)
      334190  NM_001025460.1  NP_001020631.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gus6
    gustavus
    70(a)
    1 → many
    2R(1004495-1015816)


    ENSEMBL Gene Tree for SPSB1 (if available)
    TreeFam Gene Tree for SPSB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPSB1 gene
    SPSB22  FBXO452  SPSB42  
    3 SIMAP similar genes for SPSB1 using alignment to 2 protein entries:     SPSB1_HUMAN (see all proteins):
    SPSB4    SPSB2    FBXO45

    Find genes that share paralogs with SPSB1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPSB1 (see all 1980)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs57723641,2
    C--9351018(+) TTTTCT/-TTTTT 1 -- us2k1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1406772631,2
    C--9351030(+) TTGAGA/GTGGAG 1 -- us2k10--------
    rs1457748191,2
    --9351040(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1384962701,2
    C--9351075(+) GCGATA/GTCGGC 1 -- us2k10--------
    rs1916416611,2
    --9351133(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs1420047961,2
    --9351155(+) AGGCAC/TGTACC 1 -- us2k10--------
    rs2004617201,2
    C--9351231(+) CTGAA-/CTTCTTCT 1 -- cds10--------
    rs1841586191,2
    C--9351268(+) GAGACA/GGAGTC 1 -- us2k10--------
    rs1884431831,2
    C--9351276(+) GTCTCA/GCTCTG 1 -- us2k10--------
    rs1501004981,2
    --9351306(+) GTGGCA/GCAATC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPSB1 (9352939 - 9429591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPSB1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2743574CNV Deletion23290073
    esv2743586CNV Deletion23290073
    esv2201511CNV Deletion18987734
    esv1000068CNV Insertion20482838
    nsv871098CNV Loss21882294
    nsv464172CNV Loss19166990
    dgv132n71CNV Loss21882294
    nsv832092CNV Loss17160897
    esv2750845CNV Gain17911159
    dgv3n27CNV Gain19166990

    Locus Specific Mutation Databases (LSDB): SPSB1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611657    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SPSB1:
    Keratoconus

    Find genes that share disorders with SPSB1           About GenesLikeMe

    Genetic Association Database (GAD): SPSB1
    Human Genome Epidemiology (HuGE) Navigator: SPSB1 (1 document)

    Export disorders for SPSB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPSB1 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with SPSB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway. (PubMed id 15713673)1, 2, 3, 9 Wang D.... Wu G. (J. Biol. Chem. 2005)
    2. Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis. (PubMed id 22491018)1, 4 Wang J....Platt A. (Pharmacogenomics J. 2013)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. VHL-box and SOCS-box domains determine binding specificity for Cul2- Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. (PubMed id 15601820)1, 2 Kamura T.... Nakayama K.I. (Genes Dev. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The SOCS box: a tale of destruction and degradation. (PubMed id 12076535)1, 3 Kile B.T....Hilton D.J. (Trends Biochem. Sci. 2002)
    9. Structural basis for protein recognition by B30.2/SPRY domains. (PubMed id 17189197)2, 9 Woo J.S.... Oh B.H. (Mol. Cell 2006)
    10. GWAS of dental caries patterns in the permanent dentition. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (J. Dent. Res. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80176 HGNC: 30628 AceView: SSB1 Ensembl:ENSG00000171621 euGenes: HUgn80176
    ECgene: SPSB1 H-InvDB: SPSB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPSB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPSB1 gene:
    Search GeneIP for patents involving SPSB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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