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Aliases for SPRYD4 Gene

Aliases for SPRYD4 Gene

  • SPRY Domain Containing 4 2 3 5

External Ids for SPRYD4 Gene

Previous GeneCards Identifiers for SPRYD4 Gene

  • GC12P055149
  • GC12P056863
  • GC12P053905

Summaries for SPRYD4 Gene

GeneCards Summary for SPRYD4 Gene

SPRYD4 (SPRY Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is FSD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD4 Gene

Genomics for SPRYD4 Gene

Regulatory Elements for SPRYD4 Gene

Enhancers for SPRYD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F056467 1.1 ENCODE 23.8 +0.4 426 2.6 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 NEMP1 SPRYD4 RPL41 RBMS2 LOC100131294 BAZ2A RNU6-343P CDK2 RN7SL809P ESYT1
GH12F056519 1.2 Ensembl ENCODE 14.9 +56.6 56628 11.3 PKNOX1 ATF1 SIN3A FEZF1 GLI4 YY1 ZNF121 ZNF143 ZNF263 SP3 RBMS2 SPRYD4 GC12P056589
GH12F056358 1.5 FANTOM5 ENCODE 10.6 -108.6 -108633 3.3 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 STAT2 ENSG00000257303 IL23A RNU6-343P CDK2 RBMS2 NEMP1 LOC100131294 BAZ2A RPL41
GH12F056593 1.3 Ensembl ENCODE 10.6 +125.8 125761 1.8 HDGF PKNOX1 ARNT CREB3L1 ZNF2 ZNF766 ZNF143 DEK REST SREBF1 BAZ2A RBMS2 NEMP1 RN7SL809P RNU6-343P TMEM198B SMARCC2 CDK2 ANKRD52 ESYT1
GH12F056564 1.2 Ensembl ENCODE 10.1 +99.8 99758 7.9 HDGF ELF3 HDAC1 ARID4B ZNF48 RAD21 RARA SCRT2 CEBPB PPARG RBMS2 GLS2 BAZ2A SPRYD4 APOF ATP5B SNORD59A SNORD59B NACA GC12P056589
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPRYD4 on UCSC Golden Path with GeneCards custom track

Promoters for SPRYD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001463836 -17 1401 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for SPRYD4 Gene

Chromosome:
12
Start:
56,468,517 bp from pter
End:
56,479,707 bp from pter
Size:
11,191 bases
Orientation:
Plus strand

Genomic View for SPRYD4 Gene

Genes around SPRYD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD4 Gene

Proteins for SPRYD4 Gene

  • Protein details for SPRYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW59-SPRY4_HUMAN
    Recommended name:
    SPRY domain-containing protein 4
    Protein Accession:
    Q8WW59
    Secondary Accessions:
    • A8K7A5

    Protein attributes for SPRYD4 Gene

    Size:
    207 amino acids
    Molecular mass:
    23129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRYD4 Gene

Post-translational modifications for SPRYD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRYD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRYD4 Gene

Domains & Families for SPRYD4 Gene

Protein Domains for SPRYD4 Gene

Suggested Antigen Peptide Sequences for SPRYD4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WW59

UniProtKB/Swiss-Prot:

SPRY4_HUMAN :
  • Contains 1 B30.2/SPRY domain.
Domain:
  • Contains 1 B30.2/SPRY domain.
genes like me logo Genes that share domains with SPRYD4: view

No data available for Gene Families for SPRYD4 Gene

Function for SPRYD4 Gene

Gene Ontology (GO) - Molecular Function for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPRYD4: view
genes like me logo Genes that share phenotypes with SPRYD4: view

Animal Model Products

miRNA for SPRYD4 Gene

miRTarBase miRNAs that target SPRYD4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRYD4 Gene

Localization for SPRYD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRYD4 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Gene Ontology (GO) - Cellular Components for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17852359
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SPRYD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPRYD4 Gene

Pathways & Interactions for SPRYD4 Gene

SuperPathways for SPRYD4 Gene

No Data Available

Interacting Proteins for SPRYD4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000338034%0d%0a9606.ENSP00000339007%0d%0a
Selected Interacting proteins: Q8WW59-SPRY4_HUMAN ENSP00000338034 for SPRYD4 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPRYD4: view

No data available for Pathways by source and SIGNOR curated interactions for SPRYD4 Gene

Transcripts for SPRYD4 Gene

mRNA/cDNA for SPRYD4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRYD4 Gene

SPRY domain containing 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD4 Gene

No ASD Table

Relevant External Links for SPRYD4 Gene

GeneLoc Exon Structure for
SPRYD4
ECgene alternative splicing isoforms for
SPRYD4

Expression for SPRYD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRYD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRYD4 Gene

This gene is overexpressed in Liver (x7.8).

Protein differential expression in normal tissues from HIPED for SPRYD4 Gene

This gene is overexpressed in Liver, secretome (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPRYD4 Gene



Protein tissue co-expression partners for SPRYD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRYD4 Gene:

SPRYD4

SOURCE GeneReport for Unigene cluster for SPRYD4 Gene:

Hs.128676
genes like me logo Genes that share expression patterns with SPRYD4: view

No data available for mRNA Expression by UniProt/SwissProt for SPRYD4 Gene

Orthologs for SPRYD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPRYD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRYD4 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia SPRYD4 34 35
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia SPRYD4 34 35
  • 89.05 (n)
mouse
(Mus musculus)
Mammalia Spryd4 34 16 35
  • 87.92 (n)
rat
(Rattus norvegicus)
Mammalia Spryd4 34
  • 87.6 (n)
oppossum
(Monodelphis domestica)
Mammalia SPRYD4 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPRYD4 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPRYD4 35
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii spryd4 34 35
  • 57.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for SPRYD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRYD4 Gene

ENSEMBL:
Gene Tree for SPRYD4 (if available)
TreeFam:
Gene Tree for SPRYD4 (if available)

Paralogs for SPRYD4 Gene

Paralogs for SPRYD4 Gene

(1) SIMAP similar genes for SPRYD4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPRYD4 Gene

genes like me logo Genes that share paralogs with SPRYD4: view

Variants for SPRYD4 Gene

Sequence variations from dbSNP and Humsavar for SPRYD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10124 -- 56,469,731(-) ACAAG(A/G)TAGGG utr-variant-3-prime
rs1043011 -- 56,471,256(-) AGAGA(A/C)TGGGC downstream-variant-500B, utr-variant-3-prime
rs10700116 -- 56,469,780(+) CACCA(-/AC)ACTAC utr-variant-3-prime
rs111363841 -- 56,468,369(+) TAGTT(C/T)AAATG upstream-variant-2KB
rs11171859 -- 56,466,716(+) gagtt(C/T)gagac upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRYD4 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789
nsv1052713 CNV gain 25217958
esv3629598 CNV loss 21293372
esv2667114 CNV deletion 23128226

Variation tolerance for SPRYD4 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRYD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRYD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRYD4 Gene

Disorders for SPRYD4 Gene

Relevant External Links for SPRYD4

Genetic Association Database (GAD)
SPRYD4
Human Genome Epidemiology (HuGE) Navigator
SPRYD4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRYD4

No disorders were found for SPRYD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRYD4 Gene

Publications for SPRYD4 Gene

  1. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PMID: 22286219) Kettunen J. … Ripatti S. (Nat. Genet. 2012) 3 46 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for SPRYD4 Gene

Sources for SPRYD4 Gene

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