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Aliases for SPRYD4 Gene

Aliases for SPRYD4 Gene

  • SPRY Domain Containing 4 2 3

External Ids for SPRYD4 Gene

Previous GeneCards Identifiers for SPRYD4 Gene

  • GC12P055149
  • GC12P056863
  • GC12P053905

Summaries for SPRYD4 Gene

GeneCards Summary for SPRYD4 Gene

SPRYD4 (SPRY Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is BSPRY.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD4 Gene

Genomics for SPRYD4 Gene

Genomic Location for SPRYD4 Gene

56,468,517 bp from pter
56,479,707 bp from pter
11,191 bases
Plus strand

Genomic View for SPRYD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD4 Gene

Proteins for SPRYD4 Gene

  • Protein details for SPRYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPRY domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K7A5

    Protein attributes for SPRYD4 Gene

    207 amino acids
    Molecular mass:
    23129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRYD4 Gene

Proteomics data for SPRYD4 Gene at MOPED

Post-translational modifications for SPRYD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRYD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRYD4 Gene

Domains for SPRYD4 Gene

Protein Domains for SPRYD4 Gene

Suggested Antigen Peptide Sequences for SPRYD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8WW59
  • Contains 1 B30.2/SPRY domain.
genes like me logo Genes that share domains with SPRYD4: view

No data available for Gene Families for SPRYD4 Gene

Function for SPRYD4 Gene

Gene Ontology (GO) - Molecular Function for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPRYD4: view

Phenotypes for SPRYD4 Gene

GenomeRNAi human phenotypes for SPRYD4:
genes like me logo Genes that share phenotypes with SPRYD4: view

Animal Model Products

CRISPR Products

miRNA for SPRYD4 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRYD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPRYD4 Gene

Localization for SPRYD4 Gene

Subcellular locations from

Jensen Localization Image for SPRYD4 Gene COMPARTMENTS Subcellular localization image for SPRYD4 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1

Gene Ontology (GO) - Cellular Components for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17852359
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SPRYD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPRYD4 Gene

Pathways for SPRYD4 Gene

SuperPathways for SPRYD4 Gene

No Data Available

Interacting Proteins for SPRYD4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8WW59-SPRY4_HUMAN ENSP00000338034 for SPRYD4 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPRYD4: view

No data available for Pathways by source for SPRYD4 Gene

Transcripts for SPRYD4 Gene

mRNA/cDNA for SPRYD4 Gene

(131) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRYD4 Gene

SPRY domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRYD4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD4 Gene

No ASD Table

Relevant External Links for SPRYD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRYD4 Gene

mRNA expression in normal human tissues for SPRYD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRYD4 Gene

This gene is overexpressed in Liver (7.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPRYD4 Gene

SOURCE GeneReport for Unigene cluster for SPRYD4 Gene Hs.128676

genes like me logo Genes that share expressions with SPRYD4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPRYD4 Gene

Orthologs for SPRYD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPRYD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRYD4 35
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SPRYD4 35
  • 89.86 (n)
  • 90.82 (a)
  • 90 (a)
(Canis familiaris)
Mammalia SPRYD4 35
  • 89.05 (n)
  • 89.37 (a)
  • 89 (a)
(Mus musculus)
Mammalia Spryd4 35
  • 87.92 (n)
  • 85.02 (a)
Spryd4 16
Spryd4 36
  • 85 (a)
(Monodelphis domestica)
Mammalia SPRYD4 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SPRYD4 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Spryd4 35
  • 87.6 (n)
  • 84.54 (a)
(Anolis carolinensis)
Reptilia SPRYD4 36
  • 57 (a)
(Danio rerio)
Actinopterygii spryd4 35
  • 57.82 (n)
  • 56.63 (a)
spryd4 36
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for SPRYD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRYD4 Gene

Gene Tree for SPRYD4 (if available)
Gene Tree for SPRYD4 (if available)

Paralogs for SPRYD4 Gene

Paralogs for SPRYD4 Gene

Selected SIMAP similar genes for SPRYD4 Gene using alignment to 1 proteins: Pseudogenes for SPRYD4 Gene

genes like me logo Genes that share paralogs with SPRYD4: view

Variants for SPRYD4 Gene

Sequence variations from dbSNP and Humsavar for SPRYD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs10124 -- 56,469,731(-) ACAAG(A/G)TAGGG utr-variant-3-prime
rs2657880 -- 56,469,986(-) TCAGC(C/G)ATCTG utr-variant-3-prime
rs2657881 - 56,469,102(-) CACCC(A/G)TATCA reference, missense
rs2933243 -- 56,466,793(-) ACAGA(C/T)GTGAG upstream-variant-2KB
rs7302925 -- 56,467,674(+) CCATA(A/G)TCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRYD4 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789
esv2667114 CNV Deletion 23128226

Relevant External Links for SPRYD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRYD4 Gene

Disorders for SPRYD4 Gene

Relevant External Links for SPRYD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPRYD4: view

No data available for UniProtKB/Swiss-Prot for SPRYD4 Gene

Publications for SPRYD4 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PMID: 22286219) Kettunen J. … Ripatti S. (Nat. Genet. 2012) 3 48
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Cloning and characterization of a novel human SPRYD4 gene encoding a putative SPRY domain-containing protein. (PMID: 17852359) Zhong Z. … Yu L. (DNA Seq. 2008) 3

Products for SPRYD4 Gene

Sources for SPRYD4 Gene

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