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Aliases for SPRYD4 Gene

Aliases for SPRYD4 Gene

  • SPRY Domain Containing 4 2 3 5

External Ids for SPRYD4 Gene

Previous GeneCards Identifiers for SPRYD4 Gene

  • GC12P055149
  • GC12P056863
  • GC12P053905

Summaries for SPRYD4 Gene

GeneCards Summary for SPRYD4 Gene

SPRYD4 (SPRY Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is FSD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD4 Gene

Genomics for SPRYD4 Gene

Regulatory Elements for SPRYD4 Gene

Enhancers for SPRYD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPRYD4 on UCSC Golden Path with GeneCards custom track

Promoters for SPRYD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPRYD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPRYD4 Gene

56,468,517 bp from pter
56,479,707 bp from pter
11,191 bases
Plus strand

Genomic View for SPRYD4 Gene

Genes around SPRYD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD4 Gene

Proteins for SPRYD4 Gene

  • Protein details for SPRYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPRY domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • A8K7A5

    Protein attributes for SPRYD4 Gene

    207 amino acids
    Molecular mass:
    23129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRYD4 Gene

Proteomics data for SPRYD4 Gene at MOPED

Post-translational modifications for SPRYD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRYD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRYD4 Gene

Domains & Families for SPRYD4 Gene

Protein Domains for SPRYD4 Gene

Suggested Antigen Peptide Sequences for SPRYD4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Contains 1 B30.2/SPRY domain.
genes like me logo Genes that share domains with SPRYD4: view

No data available for Gene Families for SPRYD4 Gene

Function for SPRYD4 Gene

Gene Ontology (GO) - Molecular Function for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPRYD4: view
genes like me logo Genes that share phenotypes with SPRYD4: view

Animal Model Products

miRNA for SPRYD4 Gene

miRTarBase miRNAs that target SPRYD4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRYD4 Gene

Localization for SPRYD4 Gene

Subcellular locations from

Jensen Localization Image for SPRYD4 Gene COMPARTMENTS Subcellular localization image for SPRYD4 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPRYD4 Gene

Pathways & Interactions for SPRYD4 Gene

SuperPathways for SPRYD4 Gene

No Data Available

Interacting Proteins for SPRYD4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q8WW59-SPRY4_HUMAN ENSP00000338034 for SPRYD4 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for SPRYD4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRYD4 Gene

Drugs & Compounds for SPRYD4 Gene

No Compound Related Data Available

Transcripts for SPRYD4 Gene

mRNA/cDNA for SPRYD4 Gene

Unigene Clusters for SPRYD4 Gene

SPRY domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD4 Gene

No ASD Table

Relevant External Links for SPRYD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRYD4 Gene

mRNA expression in normal human tissues for SPRYD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRYD4 Gene

This gene is overexpressed in Liver (x7.8).

Protein differential expression in normal tissues from HIPED for SPRYD4 Gene

This gene is overexpressed in Liver, secretome (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPRYD4 Gene

SOURCE GeneReport for Unigene cluster for SPRYD4 Gene Hs.128676

genes like me logo Genes that share expression patterns with SPRYD4: view

Protein tissue co-expression partners for SPRYD4 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SPRYD4 Gene

Orthologs for SPRYD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPRYD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPRYD4 35
  • 89.86 (n)
  • 90.82 (a)
  • 90 (a)
(Canis familiaris)
Mammalia SPRYD4 35
  • 89.05 (n)
  • 89.37 (a)
  • 89 (a)
(Mus musculus)
Mammalia Spryd4 35
  • 87.92 (n)
  • 85.02 (a)
Spryd4 16
Spryd4 36
  • 85 (a)
(Pan troglodytes)
Mammalia SPRYD4 35
  • 99.84 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Spryd4 35
  • 87.6 (n)
  • 84.54 (a)
(Monodelphis domestica)
Mammalia SPRYD4 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SPRYD4 36
  • 62 (a)
(Anolis carolinensis)
Reptilia SPRYD4 36
  • 57 (a)
(Danio rerio)
Actinopterygii spryd4 35
  • 57.82 (n)
  • 56.63 (a)
spryd4 36
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for SPRYD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRYD4 Gene

Gene Tree for SPRYD4 (if available)
Gene Tree for SPRYD4 (if available)

Paralogs for SPRYD4 Gene

Paralogs for SPRYD4 Gene

(1) SIMAP similar genes for SPRYD4 Gene using alignment to 1 proteins: Pseudogenes for SPRYD4 Gene

genes like me logo Genes that share paralogs with SPRYD4: view

Variants for SPRYD4 Gene

Sequence variations from dbSNP and Humsavar for SPRYD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2657881 - 56,469,102(-) CACCC(A/G)TATCA reference, missense
rs10124 -- 56,469,731(-) ACAAG(A/G)TAGGG utr-variant-3-prime
rs7302925 -- 56,467,674(+) CCATA(A/G)TCTCC upstream-variant-2KB
rs34957254 -- 56,469,779(+) CCACC(-/A)AACTA utr-variant-3-prime
rs34982799 -- 56,469,042(+) GGCGT(-/C)CAGTT reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRYD4 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV Complex 15286789
esv2667114 CNV Deletion 23128226

Variation tolerance for SPRYD4 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.79% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPRYD4 Gene

Disorders for SPRYD4 Gene

Relevant External Links for SPRYD4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPRYD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRYD4 Gene

Publications for SPRYD4 Gene

  1. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PMID: 22286219) Kettunen J. … Ripatti S. (Nat. Genet. 2012) 3 48 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PMID: 22916037) Inouye M. … de Bakker P.I. (PLoS Genet. 2012) 3

Products for SPRYD4 Gene

Sources for SPRYD4 Gene