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Aliases for SPRYD4 Gene

Aliases for SPRYD4 Gene

  • SPRY Domain Containing 4 2 3 5

External Ids for SPRYD4 Gene

Previous GeneCards Identifiers for SPRYD4 Gene

  • GC12P055149
  • GC12P056863
  • GC12P053905

Summaries for SPRYD4 Gene

GeneCards Summary for SPRYD4 Gene

SPRYD4 (SPRY Domain Containing 4) is a Protein Coding gene. An important paralog of this gene is FSD2.

Additional gene information for SPRYD4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD4 Gene

Genomics for SPRYD4 Gene

GeneHancer (GH) Regulatory Elements for SPRYD4 Gene

Promoters and enhancers for SPRYD4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I056467 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 573.8 +0.4 425 2.6 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 SPRYD4 MIP NEMP1 BAZ2A PYM1 RN7SL809P DNAJC14 STAT2
GH12I056519 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.9 +56.6 56599 11.3 PKNOX1 ATF1 SIN3A FEZF1 GLI4 ZNF121 ZNF213 ZNF143 ATF7 SP3 RBMS2 SPRYD4 GC12P056589
GH12I056358 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 10.6 -108.6 -108632 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 STAT2 BAZ2A ZC3H10 NEMP1 DNAJC14 ENSG00000257303 ENSG00000258317 IL23A PAN2 RN7SL809P
GH12I056487 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.2 +19.8 19795 1.4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 GLIS2 GLS2 DNAJC14 ZBTB39 BAZ2A ZC3H10 PRIM1 ENSG00000258317 NEMP1 RBMS2 PAN2
GH12I056768 Enhancer 0.8 FANTOM5 15.7 +300.2 300151 0.2 FOXA2 TAF1 MAX CEBPG RAD21 YY1 IRF9 CTBP1 GATA3 GATAD2A APOF HSD17B6 RDH16 SPRYD4 GLS2 GPR182 NACA MYO1A PAN2 PIR51277
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SPRYD4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SPRYD4 gene promoter:

Genomic Locations for SPRYD4 Gene

Genomic Locations for SPRYD4 Gene
chr12:56,468,517-56,479,707
(GRCh38/hg38)
Size:
11,191 bases
Orientation:
Plus strand
chr12:56,862,301-56,864,769
(GRCh37/hg19)

Genomic View for SPRYD4 Gene

Genes around SPRYD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD4 Gene

Proteins for SPRYD4 Gene

  • Protein details for SPRYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WW59-SPRY4_HUMAN
    Recommended name:
    SPRY domain-containing protein 4
    Protein Accession:
    Q8WW59
    Secondary Accessions:
    • A8K7A5

    Protein attributes for SPRYD4 Gene

    Size:
    207 amino acids
    Molecular mass:
    23129 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRYD4 Gene

Post-translational modifications for SPRYD4 Gene

No Post-translational modifications

Other Protein References for SPRYD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRYD4 Gene

Domains & Families for SPRYD4 Gene

Gene Families for SPRYD4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for SPRYD4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRYD4: view

No data available for UniProtKB/Swiss-Prot for SPRYD4 Gene

Function for SPRYD4 Gene

Phenotypes From GWAS Catalog for SPRYD4 Gene

Gene Ontology (GO) - Molecular Function for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SPRYD4: view
genes like me logo Genes that share phenotypes with SPRYD4: view

Animal Model Products

CRISPR Products

miRNA for SPRYD4 Gene

miRTarBase miRNAs that target SPRYD4

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRYD4 Gene

Localization for SPRYD4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRYD4 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17852359
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with SPRYD4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPRYD4 Gene

Pathways & Interactions for SPRYD4 Gene

SuperPathways for SPRYD4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SPRYD4: view

No data available for Pathways by source and SIGNOR curated interactions for SPRYD4 Gene

Drugs & Compounds for SPRYD4 Gene

No Compound Related Data Available

Transcripts for SPRYD4 Gene

mRNA/cDNA for SPRYD4 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(131) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRYD4 Gene

SPRY domain containing 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD4 Gene

No ASD Table

Relevant External Links for SPRYD4 Gene

GeneLoc Exon Structure for
SPRYD4
ECgene alternative splicing isoforms for
SPRYD4

Expression for SPRYD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRYD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRYD4 Gene

This gene is overexpressed in Liver (x7.8).

Protein differential expression in normal tissues from HIPED for SPRYD4 Gene

This gene is overexpressed in Liver, secretome (28.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPRYD4 Gene



Protein tissue co-expression partners for SPRYD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRYD4 Gene:

SPRYD4

SOURCE GeneReport for Unigene cluster for SPRYD4 Gene:

Hs.128676

Evidence on tissue expression from TISSUES for SPRYD4 Gene

  • Liver(4.5)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with SPRYD4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRYD4 Gene

Orthologs for SPRYD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPRYD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRYD4 33 34
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia SPRYD4 33 34
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia SPRYD4 33 34
  • 89.05 (n)
mouse
(Mus musculus)
Mammalia Spryd4 33 16 34
  • 87.92 (n)
rat
(Rattus norvegicus)
Mammalia Spryd4 33
  • 87.6 (n)
oppossum
(Monodelphis domestica)
Mammalia SPRYD4 34
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPRYD4 34
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPRYD4 34
  • 57 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii spryd4 33 34
  • 57.82 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
OneToMany
Species where no ortholog for SPRYD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRYD4 Gene

ENSEMBL:
Gene Tree for SPRYD4 (if available)
TreeFam:
Gene Tree for SPRYD4 (if available)

Paralogs for SPRYD4 Gene

Paralogs for SPRYD4 Gene

(1) SIMAP similar genes for SPRYD4 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for SPRYD4 Gene

genes like me logo Genes that share paralogs with SPRYD4: view

Variants for SPRYD4 Gene

Sequence variations from dbSNP and Humsavar for SPRYD4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000499834 -- 56,467,813(+) T/C upstream_transcript_variant
rs1001112067 -- 56,467,471(+) C/T upstream_transcript_variant
rs1001899251 -- 56,466,944(+) C/T upstream_transcript_variant
rs1002353130 -- 56,467,178(+) A/C upstream_transcript_variant
rs1003111852 -- 56,467,164(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SPRYD4 Gene

Variant ID Type Subtype PubMed ID
esv2667114 CNV deletion 23128226
esv3629598 CNV loss 21293372
nsv1052713 CNV gain 25217958
nsv482992 CNV gain+loss 15286789

Variation tolerance for SPRYD4 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SPRYD4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRYD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRYD4 Gene

Disorders for SPRYD4 Gene

Additional Disease Information for SPRYD4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for SPRYD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRYD4 Gene

Publications for SPRYD4 Gene

  1. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PMID: 22286219) Kettunen J … Ripatti S (Nature genetics 2012) 3 44 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 58

Products for SPRYD4 Gene

Sources for SPRYD4 Gene

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