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SPRYD4 Gene

protein-coding   GIFtS: 51
GCID: GC12P056863

SPRY Domain Containing 4

  Search for SPRYD4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPRY Domain Containing 41 2
SPRY Domain-Containing Protein 42

External Ids:    HGNC: 274681   Entrez Gene: 2833772   Ensembl: ENSG000001764227   UniProtKB: Q8WW593   

Export aliases for SPRYD4 gene to outside databases

Previous GC identifers: GC12P055149 GC12P053905


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPRYD4 Gene:
SPRYD4 (SPRY domain containing 4) is a protein-coding gene. An important paralog of this gene is BSPRY.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPRYD4 gene promoter:
         Sp1   AP-2alpha isoform 3   ATF-2   AP-2alpha isoform 2   Max   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SPRYD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRYD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

SPRYD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRYD4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056863:  view genomic region     (about GC identifiers)

Start:
56,862,301 bp from pter      End:
56,864,769 bp from pter
Size:
2,469 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPRY4_HUMAN, Q8WW59 (See protein sequence)
Recommended Name: SPRY domain-containing protein 4  
Size: 207 amino acids; 23129 Da
Secondary accessions: A8K7A5

Explore the universe of human proteins at neXtProt for SPRYD4: NX_Q8WW59

Explore proteomics data for SPRYD4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPRYD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997227.1  
    ENSEMBL proteins: 
     ENSP00000338034  

    SPRYD4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SPRYD4

     
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    LSBio Antibodies in human, mouse, rat for SPRYD4

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    Cloud-Clone Corp. ELISAs for SPRYD4
    Cloud-Clone Corp. CLIAs for SPRYD4
    Search eBioscience for ELISAs for SPRYD4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR003879 Butyrophylin
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q8WW59

    ProtoNet protein and cluster: Q8WW59

    1 Blocks protein domain: IPB003879 Butyrophylin C-terminal DUF signature

    UniProtKB/Swiss-Prot: SPRY4_HUMAN, Q8WW59
    Similarity: Contains 1 B30.2/SPRY domain


    Find genes that share domains with SPRYD4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SPRYD4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPRYD4:
     Decreased influenza A/WSN/33 r 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRYD4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRYD4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRYD4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPRYD4:
    hsa-let-7b-5p (MIRT001588), hsa-let-7d-5p (MIRT032172), hsa-mir-320a (MIRT044580), hsa-mir-32-5p (MIRT028369), hsa-mir-196a-5p (MIRT026083)

    Block miRNA regulation of human, mouse, rat SPRYD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRYD4 (see all 38):
    hsa-miR-124* hsa-miR-582-3p hsa-miR-429 hsa-let-7d hsa-miR-25 hsa-let-7g hsa-miR-9 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidSPRYD4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPRYD4
    Predesigned siRNA for gene silencing in human, mouse, rat SPRYD4

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRYD4 (NM_207344)
    Sino Biological Human cDNA Clone for SPRYD4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRYD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRYD4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SPRYD4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRYD4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion3
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA17852359
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with SPRYD4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRYD4
    Interactions:

        Search GeneGlobe Interaction Network for SPRYD4

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SPRYD4 (Q8WW592, 3 ENSP000003380344) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932, 3, ENSP000003390074MINT-6169726 I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with SPRYD4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRYD4 (SPRY4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPRYD4 gene: 
    NM_207344.3  

    Unigene Cluster for SPRYD4:

    SPRY domain containing 4
    Hs.128676  [show with all ESTs]
    Unigene Representative Sequence: BX647957
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000338146(uc010sqo.1 uc001sli.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPRYD4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRYD4 (see all 38):
    hsa-miR-124* hsa-miR-582-3p hsa-miR-429 hsa-let-7d hsa-miR-25 hsa-let-7g hsa-miR-9 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidSPRYD4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPRYD4
    Predesigned siRNA for gene silencing in human, mouse, rat SPRYD4
    Clone
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    OriGene clones in human, mouse for SPRYD4 (see all 8)
    OriGene ORF clones in mouse, rat for SPRYD4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRYD4 (NM_207344)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRYD4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRYD4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPRYD4
    OriGene qSTAR qPCR primer pairs in human, mouse for SPRYD4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPRYD4
      QuantiTect SYBR Green Assays in human, mouse, rat SPRYD4
      QuantiFast Probe-based Assays in human, mouse, rat SPRYD4

    Additional mRNA sequence: 

    AF289571.1 AF451989.1 AK074733.1 AK291920.1 AK300594.1 AL832247.1 BC020844.1 BX647957.1 

    4 DOTS entries:

    DT.455017  DT.100780941  DT.97822611  DT.100037901 

    Selected AceView cDNA sequences (see all 131):

    AA994425 CR624785 CB159285 CR597464 BX338532 CR601006 AI420519 AA662283 
    T95418 CR618271 BQ000494 BQ927408 AL558531 BI962647 AL580329 CD369970 
    CB135999 BF434168 BX390657 BM717197 BE280969 BM669239 BM045127 AW390704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPRYD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTTGTTC
    SPRYD4 Expression
    About this image


    SPRYD4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
     
     Liver (Hepatobiliary System)
    SPRYD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRYD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128676
        Custom PCR Arrays for SPRYD4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPRYD4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRYD4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SPRYD4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spryd41 , 5 SPRY domain containing 41, 5 87.92(n)1
    85.02(a)1
      10 (76.44 cM)5
    667011  NM_025716.21  NP_079992.11 
     1282099085 
    lizard
    (Anolis carolinensis)
    Reptilia SPRYD46
    SPRY domain containing 4
    57(a)
    1 ↔ 1
    2(93177749-93182423)
    zebrafish
    (Danio rerio)
    Actinopterygii CK397931.12   -- 70.19(n)    CK397931.1 


    ENSEMBL Gene Tree for SPRYD4 (if available)
    TreeFam Gene Tree for SPRYD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPRYD4 gene
    BSPRY2  
    1 SIMAP similar gene for SPRYD4 using alignment to 1 protein entry:     SPRY4_HUMAN:
    FSD1L

    Find genes that share paralogs with SPRYD4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SPRYD4
    PGOHUM00000249349


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPRYD4 (see all 90)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834883121,2
    --56860369(+) GGGAGA/GGGAGG 1 -- us2k10--------
    rs1174572081,2
    C,F--56860379(+) GAAGAA/GTTTTT 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs29332431,2
    C--56860577(-) ACAGAC/TGTGAG 1 -- us2k10--------
    rs1885387501,2
    --56860746(+) GACAAA/GAGAAT 1 -- us2k10--------
    rs1927607561,2
    --56860770(+) GAGGCA/GGAGGT 1 -- us2k10--------
    rs1386236951,2
    C--56860871(+) GGGCAC/TCTGTA 1 -- us2k10--------
    rs731148721,2
    C,F--56861034(+) TCCTTT/CTTTGA 1 -- us2k13Minor allele frequency- C:0.13WA NA EA 358
    rs1162066011,2
    C,F--56861282(+) TGGTCC/TCAGCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs73029251,2
    C,F,A,H--56861458(+) CCATAG/ATCTCC 1 -- us2k124Minor allele frequency- A:0.35NS EA NA WA 2490
    rs358026191,2
    C--56861510(+) GTTCAG/TAAAAC 1 -- us2k11Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for SPRYD4 (56862301 - 56864769 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPRYD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667114CNV Deletion23128226
    nsv482992CNV Complex15286789

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRYD4
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRYD4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SPRYD4           About GenesLikeMe

    Genetic Association Database (GAD): SPRYD4
    Human Genome Epidemiology (HuGE) Navigator: SPRYD4 (1 document)

    Export disorders for SPRYD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPRYD4 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SPRYD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1, 4 Kettunen J....Ripatti S. (Nat. Genet. 2012)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    5. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. (PubMed id 22916037)1 Inouye M....de Bakker P.I. (PLoS Genet. 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (Science 2009)
    8. Cloning and characterization of a novel human SPRYD4 gene encoding a putative SPRY domain-containing protein. (PubMed id 17852359)1 Zhong Z....Yu L. (DNA Seq. 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 283377 HGNC: 27468 AceView: LOC283377 Ensembl:ENSG00000176422 euGenes: HUgn283377
    ECgene: SPRYD4 H-InvDB: SPRYD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPRYD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPRYD4 gene:
    Search GeneIP for patents involving SPRYD4

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     OriGene Antibodies for SPRYD4   OriGene RNAi products in human, mouse, rat for SPRYD4  
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     Block miRNA regulation of human, mouse, rat SPRYD4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPRYD4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRYD4 Predesigned siRNA for gene silencing in human, mouse, rat SPRYD4
     QuantiFast Probe-based Assays in human, mouse, rat SPRYD4 QuantiTect SYBR Green Assays in human, mouse, rat SPRYD4
     Custom PCR Arrays for SPRYD4 Search Chromatin IP Primers for SPRYD4
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     Search Tocris compounds for SPRYD4 (SPRY4)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRYD4
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     Search Addgene for plasmids for SPRYD4
      Search eBioscience for proteins for SPRYD4
      Search eBioscience for elisas for SPRYD4
      eBioscience FlowRNA Probe Sets
           
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