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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPRYD4 Gene

protein-coding GIFtS: 49
GCID: GC12P056863

SPRY domain containing 4

Search for SPRYD4
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SPRY Domain Containing 4¹ ²
DKFZp686N0877¹
SPRY Domain-Containing Protein 4²

External Ids:	HGNC: 27468¹	Entrez Gene: 283377²	Ensembl: ENSG00000176422⁷	UniProtKB: Q8WW59³

Export aliases for SPRYD4 gene to outside databases

Previous GC identifers: GC12P055149 GC12P053905

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPRYD4 gene promoter:
Sp1 AP-2alpha isoform 3 ATF-2 AP-2alpha isoform 2 Max AP-2alpha isoform 4 AP-2alpha AP-2alphaA c-Myc
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SPRYD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRYD4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3

SPRYD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRYD4 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P056863: view genomic region (about GC identifiers)

Start:	56,862,301 bp from pter	End:	56,864,769 bp from pter
Size:	2,469 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPRY4_HUMAN, Q8WW59 (See protein sequence)

Recommended Name: SPRY domain-containing protein 4

Size: 207 amino acids; 23129 Da

Secondary accessions: A8K7A5

Explore the universe of human proteins at neXtProt for SPRYD4: NX_Q8WW59

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8WW59

SPRYD4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_997227.1

ENSEMBL proteins:

ENSP00000338034

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	17852359
GO:0005739	mitochondrion	IEA	--

SPRYD4 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPRYD4 for domains About GeneDecksing

4 InterPro domains/families:

IPR001870 B30.2/SPRY

IPR003879 Butyrophylin

IPR008985 ConA-like_lec_gl_sf

IPR003877 SPRY_rcpt

Graphical View of Domain Structure for InterPro Entry Q8WW59

ProtoNet protein and cluster: Q8WW59

1 Blocks protein family: IPB003879 Butyrophylin C-terminal DUF signature

UniProtKB/Swiss-Prot: SPRY4_HUMAN, Q8WW59

Similarity: Contains 1 B30.2/SPRY domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		miRTarBase miRNAs that target SPRYD4: hsa-let-7b (MIRT001588)

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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

SPRYD4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SPRYD4:

Decreased influenza A/WSN/33 r

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPRYD4

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SPRYD4 (Q8WW59^{2, 3} ENSP00000338034⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993²^,³, ENSP00000339007⁴	MINT-6169726 I2D: score=1 STRING: ENSP00000339007

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

SPRYD4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPRYD4
Search CenterWatch for drugs/clinical trials and news about SPRYD4 / SPRY4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for SPRYD4 gene:

NM_207344.3

Unigene Cluster for SPRYD4:

SPRY domain containing 4

Hs.128676 [show with all ESTs]

Unigene Representative Sequence: BX647957

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000338146(uc010sqo.1 uc001sli.4)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRYD4
		8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRYD4 (see all 38):
		hsa-miR-124* hsa-miR-582-3p hsa-miR-429 hsa-let-7d hsa-miR-25 hsa-let-7g hsa-miR-9 hsa-miR-133a

		SwitchGear 3'UTR luciferase reporter plasmid: SPRYD4 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRYD4

Additional cDNA sequence:

AF289571.1 AF451989.1 AK074733.1 AK291920.1 AK300594.1 AL832247.1 BC020844.1 BX647957.1

4 DOTS entries:

DT.455017 DT.100780941 DT.97822611 DT.100037901

24/131 AceView cDNA sequences (see all 131):

BX338532 AA662283 CB159285 AA994425 BQ000494 CR624785 AI420519 CR618271

CR597464 CR601006 T95418 BM669239 CD369970 AL558531 BM924285 AK074733

BI561650 BC020844 AA648944 BQ018863 BG778062 T51133 BX398291 BE745537

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPRYD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTTGTTC

About this image

SPRYD4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Secondary Spermatocyte

Germ Cells, Male Gametocytes

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPRYD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRYD4

SOURCE GeneReport for Unigene cluster: Hs.128676

SABiosciences Custom PCR Arrays for SPRYD4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRYD4 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRYD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPRYD4 gene from 3/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spryd4^{1 , 5}	SPRY domain containing 4^{1, 5}	87.92(n)¹ 85.02(a)¹		10 (76.44 cM)⁵ 66701¹ NM_025716.2¹ NP_079992.1¹ 128209908⁵
lizard (Anolis carolinensis)	Reptilia	SPRYD4⁶	--	57(a)	1 ↔ 1	2(93177761-93182423)
zebrafish (Danio rerio)	Actinopterygii	CK397931.1²	--	70.19(n)		CK397931.1

ENSEMBL Gene Tree for SPRYD4 (if available)
TreeFam Gene Tree for SPRYD4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPRYD4 gene

FSD2² CMYA5²

1 SIMAP similar gene for SPRYD4 using alignment to 1 protein entry: SPRY4_HUMAN:

FSD1L

SPRYD4 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SPRYD4
PGOHUM00000249349

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183488312^1,2		--	56860369(+)	`GGGAGA/GGGAGG`	1	--	us2k¹		0	--	--	--	--
rs117457208^1,2		--	56860379(+)	`GAAGAA/GTTTTT`	1	--	us2k¹		1		EA	120
rs2933243^1,2		--	56860577(-)	`ACAGAC/TGTGAG`	1	--	us2k¹		0	--	--	--	--
rs188538750^1,2		--	56860746(+)	`GACAAA/GAGAAT`	1	--	us2k¹		0	--	--	--	--
rs192760756^1,2		--	56860770(+)	`GAGGCA/GGAGGT`	1	--	us2k¹		0	--	--	--	--
rs138623695^1,2		--	56860871(+)	`GGGCAC/TCTGTA`	1	--	us2k¹		0	--	--	--	--
rs73114872^1,2	C,F,	--	56861034(+)	`TCCTTT/CTTTGA`	1	--	us2k¹		3		WA NA EA	358
rs116206601^1,2	F,	--	56861282(+)	`TGGTCC/TCAGCT`	1	--	us2k¹		1		WA	118
rs7302925^1,2	C,F,A,H,	--	56861458(+)	`CCATAG/ATCTCC`	1	--	us2k¹		24		NS EA NA WA	2490
rs35802619^1,2	C	--	56861510(+)	`GTTCAG/TAAAAC`	1	--	us2k¹		1		NA	2

HapMap Linkage Disequilibrium report for SPRYD4 (56862301 - 56864769 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPRYD4
1 CNV: 0164

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPRYD4 for disorders About MalaCards

SPRYD4 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: SPRYD4 (1 document)

Export disorders for SPRYD4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPRYD4 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with SPRYD4)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)¹ Kettunen J....Ripatti S. (2012)
Novel Loci for metabolic networks and multi-tissue exp ression studies reveal genes for atherosclerosis. (PubMed id 22916037)¹ Inouye M....de Bakker P.I. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
Cloning and characterization of a novel human SPRYD4 gene encoding a putative SPRY domain-containing protein. (PubMed id 17852359)¹ Zhong Z....Yu L. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 283377	HGNC: 27468	AceView: LOC283377	Ensembl:ENSG00000176422	euGenes: HUgn283377
ECgene: SPRYD4	H-InvDB: SPRYD4

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPRYD4	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPRYD4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPRYD4 gene:
Search GeneIP for patents involving SPRYD4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	OriGene Custom Antibody Services for SPRYD4		OriGene Custom Protein Services for SPRYD4
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRYD4
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRYD4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRYD4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRYD4
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRYD4
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRYD4

	GenScript Custom Purified and Recombinant Proteins Services for SPRYD4		GenScript cDNA clones with any tag delivered in your preferred vector for SPRYD4
	GenScript Custom Assay Services for SPRYD4		GenScript Custom Superior Antibodies Services for SPRYD4
	GenScript Custom overexpressing Cell Line Services for SPRYD4		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for SPRYD4 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SPRYD4
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRYD4

	SwitchGear 3'UTR luciferase reporter plasmids for SPRYD4
	Browse SwitchGear Promoter luciferase reporter plasmids for SPRYD4

ThermoFisher Antibodies for SPRYD4

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRYD4

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPRYD4 gene at Home site.

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SPRYD4 Gene

SPRY domain containing 4

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SPRYD4 Gene

SPRY domain containing 4

Aliasesfor SPRYD4 gene

Summariesfor SPRYD4 gene

Genomic Viewsfor SPRYD4 gene

Proteinsfor SPRYD4 gene

Protein Domains /Familiesfor SPRYD4 gene

Functionfor SPRYD4 gene

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Genome Databases showing SPRYD4 gene

Other Databases showing SPRYD4 gene

Specialized Databases showing SPRYD4 gene

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Aliases
for SPRYD4 gene

Summaries
for SPRYD4 gene

Genomic Views
for SPRYD4 gene

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for SPRYD4 gene

Protein Domains /
Families
for SPRYD4 gene

Function
for SPRYD4 gene

Pathways & Interactions
for SPRYD4 gene

Drugs & Compounds
for SPRYD4 gene

Transcripts
for SPRYD4 gene

Expression
for SPRYD4 gene

Orthologs
for SPRYD4 gene

Paralogs
for SPRYD4 gene

Genomic Variants
for SPRYD4 gene

Disorders / Diseases
for SPRYD4 gene

Publications
for SPRYD4 gene

Intellectual Property
for SPRYD4 gene

Products
for SPRYD4 gene