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SPRYD3 Gene

protein-coding   GIFtS: 48
GCID: GC12M053458

SPRY Domain Containing 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SPRY Domain Containing 31 2
SPRY Domain-Containing Protein 32

External Ids:    HGNC: 259201   Entrez Gene: 849262   Ensembl: ENSG000001677787   UniProtKB: Q8NCJ53   

Export aliases for SPRYD3 gene to outside databases

Previous GC identifers: GC12M051746 GC12M050501


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPRYD3 Gene:
SPRYD3 (SPRY domain containing 3) is a protein-coding gene. Diseases associated with SPRYD3 include agammaglobulinemia. An important paralog of this gene is RANBP10.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPRYD3 gene promoter:
         SRF   AP-1   SRF (504 AA)   ATF-2   Lmo2   Nkx2-5   POU2F1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRYD3 promoter sequence
   Search Chromatin IP Primers for SPRYD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRYD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

SPRYD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRYD3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M053458:  view genomic region     (about GC identifiers)

Start:
53,458,100 bp from pter      End:
53,473,204 bp from pter
Size:
15,105 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPRY3_HUMAN, Q8NCJ5 (See protein sequence)
Recommended Name: SPRY domain-containing protein 3  
Size: 442 amino acids; 49694 Da
1 PDB 3D structure from and Proteopedia for SPRYD3:
2YYO (3D)    
Secondary accessions: B9EG99 Q96SK5

Explore the universe of human proteins at neXtProt for SPRYD3: NX_Q8NCJ5

Explore proteomics data for SPRYD3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys14
  • Modification sites at PhosphoSitePlus

  • See SPRYD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116229.1  
    ENSEMBL proteins: 
     ENSP00000301463   ENSP00000448845   ENSP00000449452   ENSP00000446156  

    SPRYD3 Human Recombinant Protein Products:

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    Novus Biologicals SPRYD3 Proteins
    Novus Biologicals SPRYD3 Lysate
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    Cloud-Clone Corp. Proteins for SPRYD3

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    Novus Biologicals SPRYD3 Antibodies
    Abcam antibodies for SPRYD3
    Cloud-Clone Corp. Antibodies for SPRYD3
    ThermoFisher Antibodies for SPRYD3
    LSBio Antibodies in human, mouse, rat for SPRYD3

    SPRYD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for SPRYD3
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    Cloud-Clone Corp. ELISAs for SPRYD3
    Cloud-Clone Corp. CLIAs for SPRYD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR018355 SPla/RYanodine_receptor_subgr
     IPR008985 ConA-like_lec_gl_sf

    Graphical View of Domain Structure for InterPro Entry Q8NCJ5

    ProtoNet protein and cluster: Q8NCJ5

    UniProtKB/Swiss-Prot: SPRY3_HUMAN, Q8NCJ5
    Similarity: Contains 1 B30.2/SPRY domain


    SPRYD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    SPRYD3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRYD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPRYD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRYD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRYD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPRYD3:
    hsa-mir-221-3p (MIRT046953), hsa-mir-16-5p (MIRT031713)

    Block miRNA regulation of human, mouse, rat SPRYD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRYD3 (see all 36):
    hsa-miR-302d hsa-miR-520e hsa-miR-330-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-200a hsa-miR-138-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSPRYD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPRYD3
    Predesigned siRNA for gene silencing in human, mouse, rat SPRYD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPRYD3

    Clone
    Products:
         
    OriGene clones in human, mouse for SPRYD3 (see all 7)
    OriGene ORF clones in mouse, rat for SPRYD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRYD3 (NM_032840)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRYD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRYD3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPRYD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPRYD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRYD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytoskeleton1
    cytosol1
    nucleus1
    peroxisome1
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRYD3
    Interactions:

        Search GeneGlobe Interaction Network for SPRYD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SPRYD3 (Q8NCJ53 ENSP000003014634) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP11P517843, ENSP000002183484I2D: score=2 STRING: ENSP00000218348
    MAEAENSP000003028304STRING: ENSP00000302830
    WDR26ENSP000002950244STRING: ENSP00000295024
    ARMC8ENSP000003512214STRING: ENSP00000351221
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRYD3 (SPRY3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPRYD3 gene: 
    NM_032840.2  

    Unigene Cluster for SPRYD3:

    SPRY domain containing 3
    Hs.343334  [show with all ESTs]
    Unigene Representative Sequence: NM_032840
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301463(uc001sbt.2 uc010snw.2) ENST00000547257 ENST00000547837
    ENST00000537540 ENST00000550564 ENST00000550252
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPRYD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRYD3 (see all 36):
    hsa-miR-302d hsa-miR-520e hsa-miR-330-5p hsa-miR-15a hsa-miR-485-3p hsa-miR-200a hsa-miR-138-2* hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidSPRYD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPRYD3
    Predesigned siRNA for gene silencing in human, mouse, rat SPRYD3
    Clone
    Products:
         
    OriGene clones in human, mouse for SPRYD3 (see all 7)
    OriGene ORF clones in mouse, rat for SPRYD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRYD3 (NM_032840)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRYD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRYD3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPRYD3
    OriGene qSTAR qPCR primer pairs in human, mouse for SPRYD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPRYD3
      QuantiTect SYBR Green Assays in human, mouse, rat SPRYD3
      QuantiFast Probe-based Assays in human, mouse, rat SPRYD3

    Additional mRNA sequence: 

    AF131774.1 AK027706.1 AK074566.1 AK074694.1 AK294092.1 BC019624.1 BC136312.1 

    14 DOTS entries:

    DT.100648283  DT.95151175  DT.121118061  DT.92441319  DT.40269374  DT.121118881  DT.92441325  DT.121117889 
    DT.121118187  DT.121118666  DT.121119152  DT.95151189  DT.99981026  DT.449115 

    Selected AceView cDNA sequences (see all 197):

    BI818606 NM_032840 BP341589 AA284816 AI475083 T36169 AK027706 W71988 
    BC019624 BG575947 BU149246 CA310928 AI970619 CA306677 F05047 BP346723 
    CA432118 CR619327 CN485195 F09164 AW175662 BU625185 BM712052 Z39991 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD3    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                          -                 -                                                         
    SP2:                                                                                                      
    SP3:                                                                                                      
    SP4:                          -                                                                           
    SP5:                                                                          -                           


    ECgene alternative splicing isoforms for SPRYD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPRYD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTCCTCCCC
    SPRYD3 Expression
    About this image


    SPRYD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)
             Cerebral Cortex
    SPRYD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRYD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.343334
        Custom PCR Arrays for SPRYD3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPRYD3
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    QuantiTect SYBR Green Assays in human, mouse, rat SPRYD3
    QuantiFast Probe-based Assays in human, mouse, rat SPRYD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRYD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SPRYD3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spryd31 , 5 SPRY domain containing 31, 5 92.99(n)1
    99.55(a)1
      15 (57.30 cM)5
    2239181  NM_001033277.31  NP_001028449.21 
     1021165285 
    chicken
    (Gallus gallus)
    Aves SPRYD31 SPRY domain containing 3 80.33(n)
    88.69(a)
      100858430  XM_003643456.2  XP_003643504.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPRYD36
    SPRY domain containing 3
    88(a)
    1 ↔ 1
    GL343212.1(2793454-2842692)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.302032 Xenopus laevis transcribed sequence with moderate similarity more 77.31(n)    48023072 
    zebrafish
    (Danio rerio)
    Actinopterygii spryd31 SPRY domain containing 3 71.16(n)
    76.63(a)
      100005036  NM_001105694.1  NP_001099164.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VID306
    Protein involved in proteasome-dependent catabolit...
    6(a)
    1 → many
    VII(69671-72547) YGL227W


    ENSEMBL Gene Tree for SPRYD3 (if available)
    TreeFam Gene Tree for SPRYD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPRYD3 gene
    RANBP102  RANBP92  

    SPRYD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPRYD3 (see all 337)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440322551,2
    C--53458700(+) ACAAGC/GAGCAA 1 -- ut310--------
    rs603642581,2
    C--53458731(+) AGGAAA/GAGGGG 1 -- ut313Minor allele frequency- G:0.23WA NA 240
    rs1171725141,2
    C,F--53458786(+) CTGGGG/ATCTTG 1 -- ut311Minor allele frequency- A:0.02EA 120
    rs1871077811,2
    --53458812(+) GGAGAC/GAGGCC 1 -- ut310--------
    rs1486979311,2
    C--53458912(+) AGTGCC/TCTGTC 1 -- ut310--------
    rs1896481361,2
    --53458948(+) ATGCAA/GCAGGC 1 -- ut310--------
    rs1135678781,2
    F--53458967(+) ATGTGG/AGTCCA 1 -- ut312Minor allele frequency- A:0.50CSA 4
    rs22930601,2
    C,F,H--53459002(-) ACCACA/CGAGGA 1 -- ut31 ese329Minor allele frequency- C:0.12EA NA NS 4358
    rs22930591,2
    C,F,H--53459101(-) GTCATC/TTCTGT 1 -- ut31 ese333Minor allele frequency- T:0.12EA NA NS 4780
    rs753460791,2
    C,F--53459308(+) AGGGCC/TGGTGA 1 -- ut311Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for SPRYD3 (53458100 - 53473204 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SPRYD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv712CNV Insertion18451855
    nsv470294CNV Loss18288195
    nsv899099CNV Loss21882294
    nsv517066CNV Loss19592680
    nsv832417CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRYD3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRYD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for SPRYD3:    
    About MalaCards
    agammaglobulinemia

    1 disease from the University of Copenhagen DISEASES database for SPRYD3:
    Agammaglobulinemia

    SPRYD3 for disorders           About GeneDecksing


    Export disorders for SPRYD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPRYD3 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with SPRYD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    7. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84926 HGNC: 25920 AceView: FLJ14800 Ensembl:ENSG00000167778 euGenes: HUgn84926
    ECgene: SPRYD3 H-InvDB: SPRYD3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPRYD3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPRYD3 gene:
    Search GeneIP for patents involving SPRYD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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