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Aliases for SPRYD3 Gene

Aliases for SPRYD3 Gene

  • SPRY Domain Containing 3 2 3 5

External Ids for SPRYD3 Gene

Previous GeneCards Identifiers for SPRYD3 Gene

  • GC12M051746
  • GC12M053458
  • GC12M050501

Summaries for SPRYD3 Gene

GeneCards Summary for SPRYD3 Gene

SPRYD3 (SPRY Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is RANBP9.

Additional gene information for SPRYD3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD3 Gene

Genomics for SPRYD3 Gene

Regulatory Elements for SPRYD3 Gene

Enhancers for SPRYD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H052894 2 FANTOM5 Ensembl ENCODE dbSUPER 14 +176.5 176493 16.1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 MEF2D AAAS ZNF740 PCBP2 SP1 MAP3K12 LOC100652999 ATF7 CALCOCO1 EIF4B ENSG00000257808
GH12H052180 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.9 +891.0 890956 15.1 PKNOX1 SIN3A FEZF1 ZNF2 ZBTB7B ZNF416 FOS SP3 REST SMARCB1 ZNF740 KRT80 KRT7 HNRNPA3P10 POU6F1 SPRYD3 CSAD ENSG00000257808 C12orf80 NR4A1
GH12H053498 1.4 ENCODE dbSUPER 14 -421.2 -421187 5 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ATF7 HNRNPA1 ZNF740 PCBP2 SP1 MAP3K12 CBX5 LOC100652999 ENSG00000258344 PRR13
GH12H053060 1.6 Ensembl ENCODE dbSUPER 5.4 +12.5 12492 13.5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A YBX1 DMAP1 ZNF2 ZBTB7B AAAS PFDN5 LOC100652999 PCBP2 ATF7 ZNF740 SP1 CALCOCO1 EIF4B LOC283335
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPRYD3 on UCSC Golden Path with GeneCards custom track

Promoters for SPRYD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052144 120 1401 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207

Genomic Locations for SPRYD3 Gene

Genomic Locations for SPRYD3 Gene
15,105 bases
Minus strand

Genomic View for SPRYD3 Gene

Genes around SPRYD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRYD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRYD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD3 Gene

Proteins for SPRYD3 Gene

  • Protein details for SPRYD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPRY domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • B9EG99
    • Q96SK5

    Protein attributes for SPRYD3 Gene

    442 amino acids
    Molecular mass:
    49694 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPRYD3 Gene

neXtProt entry for SPRYD3 Gene

Post-translational modifications for SPRYD3 Gene

  • Ubiquitination at posLast=1414
  • Modification sites at PhosphoSitePlus

Other Protein References for SPRYD3 Gene

No data available for DME Specific Peptides for SPRYD3 Gene

Domains & Families for SPRYD3 Gene

Gene Families for SPRYD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for SPRYD3 Gene

Suggested Antigen Peptide Sequences for SPRYD3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRYD3: view

No data available for UniProtKB/Swiss-Prot for SPRYD3 Gene

Function for SPRYD3 Gene

Phenotypes From GWAS Catalog for SPRYD3 Gene

genes like me logo Genes that share phenotypes with SPRYD3: view

Animal Models for SPRYD3 Gene

MGI Knock Outs for SPRYD3:

miRNA for SPRYD3 Gene

miRTarBase miRNAs that target SPRYD3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRYD3 Gene

Localization for SPRYD3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRYD3 gene
Compartment Confidence
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPRYD3 Gene

Pathways & Interactions for SPRYD3 Gene

SuperPathways for SPRYD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRYD3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRYD3 Gene

Drugs & Compounds for SPRYD3 Gene

No Compound Related Data Available

Transcripts for SPRYD3 Gene

Unigene Clusters for SPRYD3 Gene

SPRY domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - -
SP4: -
SP5: -

Relevant External Links for SPRYD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRYD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRYD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPRYD3 Gene

This gene is overexpressed in Placenta (20.0), Spleen (17.2), Ovary (10.2), CD4 Tcells (10.0), and CD8 Tcells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPRYD3 Gene

Protein tissue co-expression partners for SPRYD3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPRYD3 Gene:


SOURCE GeneReport for Unigene cluster for SPRYD3 Gene:


Evidence on tissue expression from TISSUES for SPRYD3 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with SPRYD3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRYD3 Gene

Orthologs for SPRYD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPRYD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SPRYD3 33 34
  • 93.97 (n)
(Bos Taurus)
Mammalia SPRYD3 33 34
  • 93.36 (n)
(Mus musculus)
Mammalia Spryd3 33 16 34
  • 92.99 (n)
(Rattus norvegicus)
Mammalia Spryd3 33
  • 92.99 (n)
(Pan troglodytes)
Mammalia SPRYD3 33 34
  • 92.01 (n)
(Ornithorhynchus anatinus)
Mammalia SPRYD3 34
  • 73 (a)
(Gallus gallus)
Aves SPRYD3 33 34
  • 80.33 (n)
(Anolis carolinensis)
Reptilia SPRYD3 34
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spryd3 33
  • 75.84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30203 33
(Danio rerio)
Actinopterygii spryd3 34 33
  • 71.16 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6236 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 34
  • 6 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
Species where no ortholog for SPRYD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRYD3 Gene

Gene Tree for SPRYD3 (if available)
Gene Tree for SPRYD3 (if available)

Paralogs for SPRYD3 Gene

Paralogs for SPRYD3 Gene

genes like me logo Genes that share paralogs with SPRYD3: view

Variants for SPRYD3 Gene

Sequence variations from dbSNP and Humsavar for SPRYD3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000135073 -- 53,065,736(+) AGGGG(A/C)CTGCT utr-variant-3-prime
rs1000326967 -- 53,079,521(+) GGCCC(G/T)GTGCC upstream-variant-2KB
rs1000385419 -- 53,075,903(+) AAGGG(C/G)CAGCA intron-variant
rs1000774987 -- 53,080,812(+) GAATT(A/C)TTGAA upstream-variant-2KB
rs1001211710 -- 53,075,297(+) GACTT(A/G)GAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRYD3 Gene

Variant ID Type Subtype PubMed ID
nsv832417 CNV gain 17160897
nsv712 CNV insertion 18451855
nsv517066 CNV loss 19592680
nsv470294 CNV loss 18288195
dgv2644n54 CNV loss 21841781

Variation tolerance for SPRYD3 Gene

Residual Variation Intolerance Score: 15.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRYD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRYD3 Gene

Disorders for SPRYD3 Gene

Relevant External Links for SPRYD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPRYD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRYD3 Gene

Publications for SPRYD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. FBXW7 modulates cellular stress response and metastatic potential through ​HSF1 post-translational modification. (PMID: 25720964) Kourtis N … Aifantis I (Nature cell biology 2015) 3 60
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa ME … Harper JW (Cell 2009) 3 60

Products for SPRYD3 Gene

Sources for SPRYD3 Gene

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