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Aliases for SPRYD3 Gene

Aliases for SPRYD3 Gene

  • SPRY Domain Containing 3 2 3

External Ids for SPRYD3 Gene

Previous GeneCards Identifiers for SPRYD3 Gene

  • GC12M051746
  • GC12M053458
  • GC12M050501

Summaries for SPRYD3 Gene

GeneCards Summary for SPRYD3 Gene

SPRYD3 (SPRY Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is RANBP9.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRYD3 Gene

Genomics for SPRYD3 Gene

Regulatory Elements for SPRYD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPRYD3 Gene

Chromosome:
12
Start:
53,064,316 bp from pter
End:
53,079,420 bp from pter
Size:
15,105 bases
Orientation:
Minus strand

Genomic View for SPRYD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRYD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRYD3 Gene

Proteins for SPRYD3 Gene

  • Protein details for SPRYD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCJ5-SPRY3_HUMAN
    Recommended name:
    SPRY domain-containing protein 3
    Protein Accession:
    Q8NCJ5
    Secondary Accessions:
    • B9EG99
    • Q96SK5

    Protein attributes for SPRYD3 Gene

    Size:
    442 amino acids
    Molecular mass:
    49694 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SPRYD3 Gene

neXtProt entry for SPRYD3 Gene

Proteomics data for SPRYD3 Gene at MOPED

Post-translational modifications for SPRYD3 Gene

  • Ubiquitination at Lys 14
  • Modification sites at PhosphoSitePlus

Other Protein References for SPRYD3 Gene

Antibody Products

No data available for DME Specific Peptides for SPRYD3 Gene

Domains & Families for SPRYD3 Gene

Protein Domains for SPRYD3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPRYD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCJ5

UniProtKB/Swiss-Prot:

SPRY3_HUMAN :
  • Contains 1 B30.2/SPRY domain.
Domain:
  • Contains 1 B30.2/SPRY domain.
genes like me logo Genes that share domains with SPRYD3: view

No data available for Gene Families for SPRYD3 Gene

Function for SPRYD3 Gene

Gene Ontology (GO) - Molecular Function for SPRYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SPRYD3: view

Phenotypes for SPRYD3 Gene

GenomeRNAi human phenotypes for SPRYD3:
genes like me logo Genes that share phenotypes with SPRYD3: view

Animal Model Products

miRNA for SPRYD3 Gene

miRTarBase miRNAs that target SPRYD3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRYD3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRYD3 Gene

Localization for SPRYD3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRYD3 Gene COMPARTMENTS Subcellular localization image for SPRYD3 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SPRYD3 Gene

Pathways & Interactions for SPRYD3 Gene

SuperPathways for SPRYD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRYD3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPRYD3 Gene

Drugs & Compounds for SPRYD3 Gene

No Compound Related Data Available

Transcripts for SPRYD3 Gene

Unigene Clusters for SPRYD3 Gene

SPRY domain containing 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRYD3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRYD3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:
SP4: -
SP5: -

Relevant External Links for SPRYD3 Gene

GeneLoc Exon Structure for
SPRYD3
ECgene alternative splicing isoforms for
SPRYD3

Expression for SPRYD3 Gene

mRNA expression in normal human tissues for SPRYD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPRYD3 Gene

This gene is overexpressed in Placenta (20.0), Spleen (17.2), Ovary (10.2), CD4 Tcells (10.0), and CD8 Tcells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPRYD3 Gene



SOURCE GeneReport for Unigene cluster for SPRYD3 Gene Hs.343334

genes like me logo Genes that share expression patterns with SPRYD3: view

Protein tissue co-expression partners for SPRYD3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPRYD3 Gene

Orthologs for SPRYD3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPRYD3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPRYD3 35
  • 93.36 (n)
  • 99.1 (a)
SPRYD3 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPRYD3 35
  • 93.97 (n)
  • 99.55 (a)
SPRYD3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spryd3 35
  • 92.99 (n)
  • 99.55 (a)
Spryd3 16
Spryd3 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPRYD3 35
  • 92.01 (n)
  • 90.18 (a)
SPRYD3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spryd3 35
  • 92.99 (n)
  • 99.55 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SPRYD3 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPRYD3 35
  • 80.33 (n)
  • 88.69 (a)
SPRYD3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPRYD3 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spryd3 35
  • 75.84 (n)
  • 87.76 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30203 35
zebrafish
(Danio rerio)
Actinopterygii spryd3 35
  • 71.16 (n)
  • 76.63 (a)
spryd3 36
  • 76 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6236 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for SPRYD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRYD3 Gene

ENSEMBL:
Gene Tree for SPRYD3 (if available)
TreeFam:
Gene Tree for SPRYD3 (if available)

Paralogs for SPRYD3 Gene

Paralogs for SPRYD3 Gene

genes like me logo Genes that share paralogs with SPRYD3: view

Variants for SPRYD3 Gene

Sequence variations from dbSNP and Humsavar for SPRYD3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs376364138 -- 53,075,256(+) GGGCT(C/G)GGAAA intron-variant
rs376469389 -- 53,075,176(+) CCAGC(C/T)CCACA missense, reference
rs376564559 -- 53,066,478(+) GTCAT(C/T)ACTGT missense, reference
rs376607939 -- 53,077,041(+) AAGTT(-/A)AAAAA intron-variant
rs376832993 -- 53,076,916(+) TGCAC(C/T)GTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRYD3 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680
nsv899099 CNV Loss 21882294
nsv470294 CNV Loss 18288195
nsv712 CNV Insertion 18451855
nsv832417 CNV Gain 17160897

Variation tolerance for SPRYD3 Gene

Residual Variation Intolerance Score: 15.54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRYD3 Gene

HapMap Linkage Disequilibrium report
SPRYD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRYD3 Gene

Disorders for SPRYD3 Gene

Relevant External Links for SPRYD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRYD3
genes like me logo Genes that share disorders with SPRYD3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRYD3 Gene

Publications for SPRYD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 67
  2. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 67
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for SPRYD3 Gene

Sources for SPRYD3 Gene

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