Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPRY4-IT1 Gene

Subcategory (RNA class) for SPRY4-IT1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for SPRY4-IT1 Gene

  • SPRY4 Intronic Transcript 1 2 3
  • SPRY4 Intronic Transcript 1 (Non-Protein Coding) 2

External Ids for SPRY4-IT1 Gene

Previous GeneCards Identifiers for SPRY4-IT1 Gene

  • GC05U901574

Summaries for SPRY4-IT1 Gene

Entrez Gene Summary for SPRY4-IT1 Gene

  • This gene produces a non-coding RNA that is upregulated in several different tumors, including melanoma and breast and prostate cancer cells. This transcript may mediate cell growth, proliferation, and apoptosis. It regulates levels of lipin 2, and therefore may be involved in lipid biosynthesis. The primary transcript is cleaved to release a mature product that localizes to the cytoplasm (PMID:25344859). The full length structure of the primary and cleaved transcripts is unclear, and it is possible that the primary transcript is a splice variant of SPRY4 (GeneID:81848). [provided by RefSeq, Mar 2015]

GeneCards Summary for SPRY4-IT1 Gene

SPRY4-IT1 (SPRY4 Intronic Transcript 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY4-IT1 Gene

Genomics for SPRY4-IT1 Gene

Genomic Location for SPRY4-IT1 Gene

Chromosome:
5
Start:
142,317,620 bp from pter
End:
142,318,322 bp from pter
Size:
703 bases
Orientation:
Minus strand

Genomic View for SPRY4-IT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRY4-IT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for Regulatory Elements and RefSeq DNA sequence for SPRY4-IT1 Gene

Proteins for SPRY4-IT1 Gene

Post-translational modifications for SPRY4-IT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SPRY4-IT1 Gene

Domains & Families for SPRY4-IT1 Gene

Gene Families for SPRY4-IT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRY4-IT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPRY4-IT1 Gene

Function for SPRY4-IT1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRY4-IT1 Gene

Localization for SPRY4-IT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPRY4-IT1 Gene

Pathways & Interactions for SPRY4-IT1 Gene

SuperPathways for SPRY4-IT1 Gene

No Data Available

Interacting Proteins for SPRY4-IT1 Gene

Gene Ontology (GO) - Biological Process for SPRY4-IT1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SPRY4-IT1 Gene

Drugs & Compounds for SPRY4-IT1 Gene

No Compound Related Data Available

Transcripts for SPRY4-IT1 Gene

mRNA/cDNA for SPRY4-IT1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY4-IT1 Gene

No ASD Table

Relevant External Links for SPRY4-IT1 Gene

GeneLoc Exon Structure for
SPRY4-IT1
ECgene alternative splicing isoforms for
SPRY4-IT1

Expression for SPRY4-IT1 Gene

mRNA expression in normal human tissues for SPRY4-IT1 Gene

mRNA expression in normal human tissues for SPRY4-IT1 Gene

SOURCE GeneReport for Unigene cluster for SPRY4-IT1 Gene Hs.684549

genes like me logo Genes that share expression patterns with SPRY4-IT1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPRY4-IT1 Gene

Orthologs for SPRY4-IT1 Gene

Evolution for SPRY4-IT1 Gene

ENSEMBL:
Gene Tree for SPRY4-IT1 (if available)
TreeFam:
Gene Tree for SPRY4-IT1 (if available)

No data available for Orthologs for SPRY4-IT1 Gene

Paralogs for SPRY4-IT1 Gene

No data available for Paralogs for SPRY4-IT1 Gene

Variants for SPRY4-IT1 Gene

Relevant External Links for SPRY4-IT1 Gene

HapMap Linkage Disequilibrium report
SPRY4-IT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SPRY4-IT1 Gene

Disorders for SPRY4-IT1 Gene

Relevant External Links for SPRY4-IT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRY4-IT1
genes like me logo Genes that share disorders with SPRY4-IT1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRY4-IT1 Gene

Publications for SPRY4-IT1 Gene

  1. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. (PMID: 21558391) Khaitan D. … Perera R.J. (Cancer Res. 2011) 2 67
  2. Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma. (PMID: 25608466) Tong Y.S. … Cao X.F. (Mol. Cancer 2015) 67
  3. Increased expression of SPRY4-IT1 predicts poor prognosis and promotes tumor growth and metastasis in bladder cancer. (PMID: 25973088) Zhao X.L. … Du X.Y. (Int J Clin Exp Pathol 2015) 67
  4. The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression. (PMID: 25742952) Shi Y. … Shu Y. (Mol. Cancer 2015) 67
  5. Decreased long noncoding RNA SPRY4-IT1 contributing to gastric cancer cell metastasis partly via affecting epithelial-mesenchymal transition. (PMID: 26238992) Xie M. … Liu X.H. (J Transl Med 2015) 67

Products for SPRY4-IT1 Gene

Sources for SPRY4-IT1 Gene

Back to Top

Content