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Aliases for SPRY4-IT1 Gene

Subcategory (RNA class) for SPRY4-IT1 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for SPRY4-IT1 Gene

  • SPRY4 Intronic Transcript 1 2 3 5
  • SPRY4 Intronic Transcript 1 (Non-Protein Coding) 2 3

External Ids for SPRY4-IT1 Gene

Previous GeneCards Identifiers for SPRY4-IT1 Gene

  • GC05U901574

Summaries for SPRY4-IT1 Gene

Entrez Gene Summary for SPRY4-IT1 Gene

  • This gene produces a non-coding RNA that is upregulated in several different tumors, including melanoma and breast and prostate cancer cells. This transcript may mediate cell growth, proliferation, and apoptosis. It regulates levels of lipin 2, and therefore may be involved in lipid biosynthesis. The primary transcript is cleaved to release a mature product that localizes to the cytoplasm (PMID:25344859). The full length structure of the primary and cleaved transcripts is unclear, and it is possible that the primary transcript is a splice variant of SPRY4 (sprouty RTK signaling antagonist 4). [provided by RefSeq, Feb 2016]

GeneCards Summary for SPRY4-IT1 Gene

SPRY4-IT1 (SPRY4 Intronic Transcript 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY4-IT1 Gene

Genomics for SPRY4-IT1 Gene

Regulatory Elements for SPRY4-IT1 Gene

Enhancers for SPRY4-IT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F142314 0.8 Ensembl ENCODE 0.8 -3.4 -3399 13.8 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 PCDHGA11 LINC01844 ENSG00000261757 LOC101926941 SPRY4-IT1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SPRY4-IT1 on UCSC Golden Path with GeneCards custom track

Promoters for SPRY4-IT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001874543 -1578 201 SCRT2 HNF4G ZNF652

Genomic Location for SPRY4-IT1 Gene

142,317,620 bp from pter
142,318,322 bp from pter
703 bases
Minus strand

Genomic View for SPRY4-IT1 Gene

Genes around SPRY4-IT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRY4-IT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRY4-IT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY4-IT1 Gene

Proteins for SPRY4-IT1 Gene

Post-translational modifications for SPRY4-IT1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SPRY4-IT1 Gene

Domains & Families for SPRY4-IT1 Gene

Gene Families for SPRY4-IT1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPRY4-IT1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for SPRY4-IT1 Gene

Function for SPRY4-IT1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRY4-IT1 Gene

Localization for SPRY4-IT1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPRY4-IT1 Gene

Pathways & Interactions for SPRY4-IT1 Gene

SuperPathways for SPRY4-IT1 Gene

No Data Available

Interacting Proteins for SPRY4-IT1 Gene

Gene Ontology (GO) - Biological Process for SPRY4-IT1 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRY4-IT1 Gene

Transcripts for SPRY4-IT1 Gene

mRNA/cDNA for SPRY4-IT1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY4-IT1 Gene

No ASD Table

Relevant External Links for SPRY4-IT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRY4-IT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRY4-IT1 Gene

mRNA expression in normal human tissues for SPRY4-IT1 Gene

SOURCE GeneReport for Unigene cluster for SPRY4-IT1 Gene:

genes like me logo Genes that share expression patterns with SPRY4-IT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SPRY4-IT1 Gene

Orthologs for SPRY4-IT1 Gene

Evolution for SPRY4-IT1 Gene

Gene Tree for SPRY4-IT1 (if available)
Gene Tree for SPRY4-IT1 (if available)

No data available for Orthologs for SPRY4-IT1 Gene

Paralogs for SPRY4-IT1 Gene

No data available for Paralogs for SPRY4-IT1 Gene

Variants for SPRY4-IT1 Gene

Sequence variations from dbSNP and Humsavar for SPRY4-IT1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs111589332 -- 142,318,805(+) CTTAC(A/G)AACTG intron-variant, upstream-variant-2KB
rs112903524 -- 142,317,136(+) GGTCA(A/G)GGCTG intron-variant, downstream-variant-500B, utr-variant-5-prime
rs114512677 -- 142,318,877(+) GAAGC(G/T)GCTAA intron-variant, upstream-variant-2KB
rs118014547 -- 142,319,354(+) GGAAG(A/G)CTCAG intron-variant, upstream-variant-2KB
rs137911332 -- 142,318,765(+) CTTAG(C/G)CAAAG intron-variant, upstream-variant-2KB

Relevant External Links for SPRY4-IT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for SPRY4-IT1 Gene

Disorders for SPRY4-IT1 Gene

Relevant External Links for SPRY4-IT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPRY4-IT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRY4-IT1 Gene

Publications for SPRY4-IT1 Gene

  1. The Long Noncoding RNA SPRIGHTLY Regulates Cell Proliferation in Primary Human Melanocytes. (PMID: 26829028) Zhao W. … Perera R.J. (J. Invest. Dermatol. 2016) 2 3 64
  2. The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion. (PMID: 21558391) Khaitan D. … Perera R.J. (Cancer Res. 2011) 2 3 64
  3. Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins. (PMID: 26680741) Xiao L. … Wang J.Y. (Mol. Biol. Cell 2016) 3 64
  4. Identification of the long non-coding RNA POU3F3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma. (PMID: 25608466) Tong Y.S. … Cao X.F. (Mol. Cancer 2015) 3 64
  5. The long noncoding RNA SPRY4-IT1 increases the proliferation of human breast cancer cells by upregulating ZNF703 expression. (PMID: 25742952) Shi Y. … Shu Y. (Mol. Cancer 2015) 3 64

Products for SPRY4-IT1 Gene

Sources for SPRY4-IT1 Gene

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