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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPRY4 Gene

protein-coding GIFtS: 59
GCID: GC05M141670

sprouty homolog 4 (Drosophila)

Explore 6 diseases affiliated with
SPRY4 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sprouty Homolog 4 (Drosophila)¹ ²
Protein Sprouty Homolog 4²
Spry-4³
Spry-4³

External Ids:	HGNC: 15533¹	Entrez Gene: 81848²	Ensembl: ENSG00000187678⁷	OMIM: 607984⁵	UniProtKB: Q9C004³

Export aliases for SPRY4 gene to outside databases

Previous GC identifers: GC05P141577 GC05M142272 GC05M141674 GC05M141718 GC05M136836

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPRY4:

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is

positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et

al., 2002 (PubMed 12027893)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: SPY4_HUMAN, Q9C004

Function: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK

activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent,

but not Ras-dependent, activation of RAF1

Gene Wiki entry for SPRY4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_029289.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPRY4 gene promoter:
Sox5 GCNF CUTL1 PPAR-gamma1 POU2F1 POU2F1a GCNF-1 STAT3 PPAR-gamma2 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPRY4 promoter sequence

Search SABiosciences Chromatin IP Primers for SPRY4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRY4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3

SPRY4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY4 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M141670: view genomic region (about GC identifiers)

Start:	141,689,992 bp from pter	End:	141,706,020 bp from pter
Size:	16,029 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPY4_HUMAN, Q9C004 (See protein sequence)

Recommended Name: Protein sprouty homolog 4

Size: 299 amino acids; 32541 Da

Subunit: Interacts with the C-terminus of TESK1. Interacts with RAF1

Subcellular location: Cytoplasm. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side

(Potential)

Sequence caution: Sequence=AAK00652.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for SPRY4:

3BUN (3D)

Secondary accessions: A4FVB2 A4FVB3 Q6QIX2 Q9C003

Alternative splicing: 2 isoforms: Q9C004-1 Q9C004-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPRY4: NX_Q9C004

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9C004

SPRY4 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001120968.1 NP_112226.2

ENSEMBL proteins:

ENSP00000344967 ENSP00000399468 ENSP00000424411

Human Recombinant Protein Products:

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	Novus Biologicals SPRY4 Protein Novus Biologicals SPRY4 Lysate
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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SPRY4

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0032587	ruffle membrane	IEA	--

SPRY4 for ontologies About GeneDecksing

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	ThermoFisher Antibody for SPRY4

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	Uscn ELISAs and CLIAs for SPRY4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPRY4 for domains About GeneDecksing

1 InterPro domain/family:

IPR007875 Sprouty

Graphical View of Domain Structure for InterPro Entry Q9C004

ProtoNet protein and cluster: Q9C004

1 Blocks protein family: IPB007875 Sprouty

UniProtKB/Swiss-Prot: SPY4_HUMAN, Q9C004

Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles

Similarity: Belongs to the sprouty family

Similarity: Contains 1 SPR (sprouty) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPY4_HUMAN, Q9C004

Function: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK

activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent,

but not Ras-dependent, activation of RAF1

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPRY4 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY4
		8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY4 (see all 90):
		hsa-miR-140-5p hsa-miR-300 hsa-miR-411 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-138-2* hsa-miR-519a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRY4 (see all 7) OriGene shRNA RFP: SPRY4 OriGene siRNA: SPRY4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRY4

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SPRY4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPRY4 (NM_030964)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPRY4
		Search LifeMap BioReagents cell lines for SPRY4

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY4

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12027893

SPRY4 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SPRY4:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for SPRY4: Spry4^tm1.2Mrt Spry4^tm1Ayos
9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Spry4):

craniofacial	growth/size	limbs/digits/tail	mortality/aging	nervous system
no phenotypic analysis	respiratory system	skeleton	vision/eye

SPRY4 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Jak-STAT signaling pathway

Jak-STAT signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for SPRY4):

Jak-STAT signaling pathway

SPRY4 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SPRY4

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/8 Interacting proteins for SPRY4 (Q9C004^{1, 2, 3} ENSP00000344967⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBL	P22681²^,³, ENSP00000264033⁴	MINT-6539615 MINT-6539242 MINT-6539271 MINT-6539257 MINT-6539196 MINT-6539182 MINT-6538940 MINT-6539167 MINT-6538999 I2D: score=2 STRING: ENSP00000264033
TESK1	Q15569¹^,³, ENSP00000338127⁴	EBI-354861,EBI-354852 I2D: score=3 STRING: ENSP00000338127
RAF1	P04049³, ENSP00000251849⁴	I2D: score=3 STRING: ENSP00000251849
SPRY2	O43597³	I2D: score=2
GRB2	P62993³	I2D: score=1

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--
GO:0043407	negative regulation of MAP kinase activity	IEA	--

SPRY4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPRY4

1 HMDB Compound for SPRY4 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about SPRY4 / SPY4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPRY4 gene (2 alternative transcripts):

NM_001127496.1 NM_030964.3

Unigene Cluster for SPRY4:

Sprouty homolog 4 (Drosophila)

Hs.323308 [show with all ESTs]

Unigene Representative Sequence: AK226147

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000344120(uc010jgi.1 uc003lml.2) ENST00000434127 ENST00000511815

ENST00000503582 ENST00000509364

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SPRY4 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY4
		8/90 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY4 (see all 90):
		hsa-miR-140-5p hsa-miR-300 hsa-miR-411 hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-138-2* hsa-miR-519a

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRY4 (see all 7) OriGene shRNA RFP: SPRY4 OriGene siRNA: SPRY4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRY4

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY4 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPRY4 (NM_030964)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRY4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPRY4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRY4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY4

Additional cDNA sequence:

AF227516.1 AF251060.1 AK096464.1 AK226147.1 BC125095.1 BC125096.1 BC141945.1

4 DOTS entries:

DT.91979599 DT.100774002 DT.95189209 DT.40232222

24/101 AceView cDNA sequences (see all 101):

BF589430 AA327851 CR605362 BF477472 BQ227264 BX101620 W48843 AF251060

AA292057 AI951419 BU682128 CB997273 BX330414 AA857230 BE906669 T35235

CB990941 AI683184 BQ677112 F06813 BG109652 AI038889 BU789679 W56562

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SPRY4 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d
SP1:					-		-				-
SP2:
SP3:					-		-		-		-
SP4:									-		-

ECgene alternative splicing isoforms for SPRY4

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPRY4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACAAACAG

About this image

SPRY4 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Mesoderm

Distal Mesodermal Progenitor Cells

Lung

Neural Tube

Spinal Neural Tube Cells

Neural Ectoderm

Limb

Limb

Limb

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor EN13 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Definitive endoderm-like cells (A scalable, suspensi...)

Epiblast-like cells (Reconstitution of mo...)

See SPRY4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRY4

SOURCE GeneReport for Unigene cluster: Hs.323308

SABiosciences Custom PCR Arrays for SPRY4

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRY4 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY4

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SPRY4 gene from 6/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spry4^{1 , 5}	sprouty homolog 4 (Drosophila)^{1, 5}	88.63(n)¹ 92.98(a)¹		18 (20.50 cM)⁵ 24066¹ NM_011898.2¹ NP_036028.2¹ 38586268⁵
chicken (Gallus gallus)	Aves	LOC100858637¹	protein sprouty homolog 4-like	78.11(n) 76.77(a)		100858637 XM_003642098.1 XP_003642146.1
lizard (Anolis carolinensis)	Reptilia	SPRY4⁶	--	74(a)	1 ↔ 1	2(126932490-126933392)
tropical clawed frog (Xenopus tropicalis)	Amphibia	142008609²	--	93.15(n)		142008609
zebrafish (Danio rerio)	Actinopterygii	spry4²	sprouty (Drosophila) homolog 4	76.97(n)		114437 AF371368.1
fruit fly (Drosophila melanogaster)	Insecta	sty⁶	sprouty	14(a)	1 → many	3L(3401137-3424935)

ENSEMBL Gene Tree for SPRY4 (if available)
TreeFam Gene Tree for SPRY4 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPRY4 gene

SPRY3² SPRY1² SPRY2²

3 SIMAP similar genes for SPRY4 using alignment to 2 protein entries: SPY4_HUMAN (see all proteins):

SPRY3 SPRY1 SPRY2

SPRY4 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186311509^1,2		--	141689521(+)	`CTTTCA/GAGGCT`	2	--	ds500¹		0	--	--	--	--
rs148616884^1,2		--	141689546(+)	`TGTGCA/GATATG`	2	--	ds500¹		0	--	--	--	--
rs116595746^1,2	F,	--	141689630(+)	`TTCATG/ATGTGT`	2	--	ds500¹		1		WA	118
rs191054557^1,2		--	141689679(+)	`AGGAAA/TGGACA`	2	--	ds500¹		0	--	--	--	--
rs78386426^1,2		--	141689681(+)	`GAATGG/AACAGG`	2	--	ds500¹		1		EA	120
rs142734365^1,2		--	141689712(+)	`TCTACC/TTCTTC`	2	--	ds500¹		0	--	--	--	--
rs182170945^1,2		--	141689776(+)	`CTTTCC/TCAGGA`	2	--	ds500¹		0	--	--	--	--
rs7723984^1,2	C,F,A,H,	--	141689777(+)	`TTTCCT/CAGGAA`	2	--	ds500¹		20		NS EA NA WA CSA	2345
rs75447760^1,2		--	141689899(+)	`GCCCTA/GTCTTC`	2	--	ds500¹		0	--	--	--	--
rs186151894^1,2		--	141690155(+)	`TATTCA/TATACA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPRY4 (141689992 - 141706020 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPRY4: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRY4

DNA2.0 Custom Variant and Variant Library Synthesis for SPRY4

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPRY4 for disorders           About GeneDecksing

OMIM gene information: 607984    OMIM disorders: --

6 diseases for SPRY4:    About MalaCards

testicular germ cell cancer germ cell cancer lung cancer prostate cancer

prostatitis schizophrenia

1 disease from the University of Copenhagen DISEASES database for SPRY4:

Testicular cancer

Human Genome Epidemiology (HuGE) Navigator: SPRY4 (3 documents)

Export disorders for SPRY4 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPRY4 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with SPRY4)

Utopia: connect your pdf to the dynamic
world of online information

Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. (PubMed id 14977631)^{1, 2, 9} Ding W.... Warburton D. (2004)
FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PubMed id 16465403)^{1, 3} Katoh Y. and Katoh M. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. (PubMed id 12717443)^{1, 2} Sasaki A....Yoshimura A. (2003)
Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. (PubMed id 12027893)^{1, 2} Leeksma O.C.... de Vries C.J.M. (2002)
Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. (PubMed id 23074222)¹ Sharma B....Platanias L.C. (2012)
Associations between variants in KITLG, SPRY4, BAK1, a nd DMRT1 and pediatric germ cell tumors. (PubMed id 22072546)¹ Poynter J.N....Ross J.A. (2012)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Sprouty4 levels are increased under hypoxic condition s by enhanced mRNA stability and transcription. (PubMed id 20482313)¹ Haigl B....SutterlA1ty H. (2010)
Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer. (PubMed id 20501643)¹ Tennis M.A....Winn R.A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 81848	HGNC: 15533	AceView: SPRY4	Ensembl:ENSG00000187678	euGenes: HUgn81848
ECgene: SPRY4	Kegg: 81848	H-InvDB: SPRY4

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for SPRY4	Pharmacogenomics, SNPs, Pathways

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sprouty homolog 4 (Drosophila)

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sprouty homolog 4 (Drosophila)

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