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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRY3 Gene

protein-coding   GIFtS: 51
GCID: GC0XP154997

sprouty homolog 3 (Drosophila)

(Previous name: sprouty (Drosophila) homolog 2 )
  Search for SPRY3
in our new
 Human Malady Compendium 
Biological research products
for SPRY3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Sprouty Homolog 3 (Drosophila)1 2     Protein Sprouty Homolog 32
HSPRY31 2     Spry-33
Sprouty (Drosophila) Homolog 21     Spry-33
Antagonist Of FGF Signaling2     

External Ids:    HGNC: 112711   Entrez Gene: 102512   Ensembl: ENSG000001689397   OMIM: 3005315   UniProtKB: O436103   

Export aliases for SPRY3 gene to outside databases

Previous GC identifers: GC00U990472 GC0YM050220 GC0XP153429 GC0YP057438 GC0XP154561 GC0XP154650 GC0XP143477


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610
Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
respiratory organogenesis

Gene Wiki entry for SPRY3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_000024.9  NC_018934.1  NT_167198.1  NT_167206.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRY3 gene promoter:
         HFH-1   Nkx2-2   Nkx2-5   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRY3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRY3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 and Yq12   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28 and Yq12

SPRY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP154997:  view genomic region     (about GC identifiers)

Start:
154,997,451 bp from pter      End:
155,012,121 bp from pter
Size:
14,671 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 59,100,457-59,115,123     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610 (See protein sequence)
Recommended Name: Protein sprouty homolog 3  
Size: 288 amino acids; 31222 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated
cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor)
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y
chromosomes
Sequence caution: Sequence=AAC39567.1; Type=Frameshift; Positions=96;
Secondary accessions: A8K0H8

Explore the universe of human proteins at neXtProt for SPRY3: NX_O43610

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43610

  • SPRY3 Protein expression data from MOPED and PaxDb:    About this image 
    SPRY3 Protein Expression
    REFSEQ proteins: NP_005831.1  
    ENSEMBL proteins: 
     ENSP00000302978  

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    Uscn Proteins for SPRY3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane NAS--

    SPRY3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SPRY3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007875 Sprouty

    Graphical View of Domain Structure for InterPro Entry O43610

    ProtoNet protein and cluster: O43610

    1 Blocks protein family: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610
    Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
    Similarity: Belongs to the sprouty family
    Similarity: Contains 1 SPR (sprouty) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPY3_HUMAN, O43610
    Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
    respiratory organogenesis
    Induction: By FGF signaling

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    SPRY3 for ontologies           About GeneDecksing


    Animal Models:
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    hsa-miR-576-3p hsa-miR-579 hsa-miR-520f hsa-miR-3938 hsa-miR-128 hsa-miR-1245 hsa-miR-3074-3p hsa-miR-342-3p
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Jak-STAT signaling pathway
    Jak-STAT signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for SPRY3):
        Jak-STAT signaling pathway


    SPRY3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRY3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for SPRY3 (O436103 ENSP000003029784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TESK1Q155693, ENSP000003381274I2D: score=1 STRING: ENSP00000338127
    GRB2P629933I2D: score=1 
    SOS1Q078893I2D: score=1 
    SPRY2O435973I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development NAS9458049
    GO:0009966regulation of signal transduction IEA--

    SPRY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRY3
    Search CenterWatch for drugs/clinical trials and news about SPRY3 / SPY3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRY3 gene: 
    NM_005840.1  

    Unigene Cluster for SPRY3:

    Sprouty homolog 3 (Drosophila)
    Hs.381912  [show with all ESTs]
    Unigene Representative Sequence: NM_005840
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302805(uc004fnq.1)

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    hsa-miR-576-3p hsa-miR-579 hsa-miR-520f hsa-miR-3938 hsa-miR-128 hsa-miR-1245 hsa-miR-3074-3p hsa-miR-342-3p
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    Inhib. RNA
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    Additional cDNA sequence: 

    AF041038.1 AK094610.1 AK125483.1 AK289543.1 AK311508.1 BC069609.1 BC074972.2 BC074973.2 

    5 DOTS entries:

    DT.110016  DT.120654065  DT.120654064  DT.40286527  DT.91907383 

    24/34 AceView cDNA sequences (see all 34):

    BC074973 BC069609 N52233 NM_005840 BC074972 H24223 BU164699 BQ228300 
    AI754212 AA994998 AK125483 AA682860 AA933967 R42219 BM311383 BQ012402 
    BU685186 BX115815 AA650036 BM932153 N73200 AI038709 BM311977 X97511 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRY3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAGCCAAG
    SPRY3 Expression
    About this image
    See SPRY3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRY3

    SOURCE GeneReport for Unigene cluster: Hs.381912

    UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610
    Tissue specificity: Widely expressed; particularly in the fetal tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPRY3 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SPRY31 sprouty homolog 3 (Drosophila) 70.7(n)
    66.55(a)
      428712  NM_001079736.1  NP_001073204.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPRY36
    --
    59(a)
    1 ↔ 1
    GL343202.1(2023560-2024420)
    zebrafish
    (Danio rerio)
    Actinopterygii wufk66h112 Transcribed sequence with moderate similarity to protein more 75.45(n)    57092611 
    fruit fly
    (Drosophila melanogaster)
    Insecta sty6
    sprouty
    14(a)
    1 → many
    3L(3401137-3424935)


    ENSEMBL Gene Tree for SPRY3 (if available)
    TreeFam Gene Tree for SPRY3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPRY3 gene
    SPRY12  SPRY22  SPRY42  
    3 SIMAP similar genes for SPRY3 using alignment to 1 protein entry:     SPY3_HUMAN:
    SPRY2    SPRY4    SPRY1

    SPRY3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SPRY3
         1 CNV: 0828
    Human Gene Mutation Database (HGMD): SPRY3
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRY3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRY3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPRY3 for disorders           About MalaCards

    SPRY3 for disorders           About GeneDecksing

    OMIM gene information: 300531    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: SPRY3 (1 document)

    Export disorders for SPRY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRY3 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SPRY3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)1, 2, 3 Hacohen N.... Krasnow M.A. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)1, 2 Ciccodicola A.... D'Urso M. (2000)
    5. Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. (PubMed id 17974561)1 Chandramouli S....Guy G.R. (2008)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    7. A functional interaction between sprouty proteins and caveolin-1. (PubMed id 16877379)1 Cabrita M.A....Christofori G. (2006)
    8. Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. (PubMed id 16500999)1 De Bonis M.L....D'Esposito M. (2006)
    9. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    10. Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. (PubMed id 15950061)1 Anteby E.Y....Yagel S. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10251 HGNC: 11271 AceView: SPRY3 Ensembl:ENSG00000168939 euGenes: HUgn10251
    ECgene: SPRY3 Kegg: 10251 H-InvDB: SPRY3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRY3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPRY3 gene:
    Search GeneIP for patents involving SPRY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
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     Browse OriGene Antibodies   OriGene shRNA RFP for SPRY3  
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     Regulatory tfbs in SPRY3 promoter
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     SPRY3 Proteins, Antibodies, CLIAs, and ELISAs
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    Sirion Biotech Customized:
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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