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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRY3 Gene

protein-coding   GIFtS: 47
GCID: GC0XP154997

Sprouty Homolog 3 (Drosophila)

(Previous name: sprouty (Drosophila) homolog 2)
  Search for SPRY3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sprouty Homolog 3 (Drosophila)1 2     Protein Sprouty Homolog 32
Antagonist Of FGF Signaling1 2     spry-32
Sprouty (Drosophila) Homolog 21     Spry-33
HSPRY32     

External Ids:    HGNC: 112711   Entrez Gene: 102512   Ensembl: ENSG000001689397   OMIM: 3005315   UniProtKB: O436103   

Export aliases for SPRY3 gene to outside databases

Previous GC identifers: GC00U990472 GC0YM050220 GC0XP153429 GC0YP057438 GC0XP154561 GC0XP154650 GC0XP143477


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPRY3 Gene: 
SPRY3 (sprouty homolog 3 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include molecular_function. An important paralog of this gene is SPRY1.

UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610
Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
respiratory organogenesis

Gene Wiki entry for SPRY3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  NC_000024.9  NT_167206.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRY3 gene promoter:
         HFH-1   Nkx2-2   Nkx2-5   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRY3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRY3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 and Yq12   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28 and Yq12

SPRY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY3 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP154997:  view genomic region     (about GC identifiers)

Start:
154,997,451 bp from pter      End:
155,012,121 bp from pter
Size:
14,671 bases      Orientation:
plus strand

1 alternative location:
ChrY+ 59,100,457-59,115,123     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610 (See protein sequence)
Recommended Name: Protein sprouty homolog 3  
Size: 288 amino acids; 31222 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in
unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth
factor)
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y
chromosomes
Sequence caution: Sequence=AAC39567.1; Type=Frameshift; Positions=96;
Secondary accessions: A8K0H8

Explore the universe of human proteins at neXtProt for SPRY3: NX_O43610

Explore proteomics data for SPRY3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43610

  • SPRY3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPRY3 Protein Expression
    REFSEQ proteins: NP_005831.1  
    ENSEMBL proteins: 
     ENSP00000302978  

    Human Recombinant Protein Products for SPRY3: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016020membrane NAS--

    SPRY3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PAR2: Pseudoautosomal regions / PAR2

    1 InterPro protein domain:
     IPR007875 Sprouty

    Graphical View of Domain Structure for InterPro Entry O43610

    ProtoNet protein and cluster: O43610

    1 Blocks protein domain: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610
    Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
    Similarity: Belongs to the sprouty family
    Similarity: Contains 1 SPR (sprouty) domain


    SPRY3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPY3_HUMAN, O43610
    Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
    respiratory organogenesis
    Induction: By FGF signaling

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    SPRY3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRY3 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRY3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for SPRY3 (O436103 ENSP000003029784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TESK1Q155693, ENSP000003381274I2D: score=1 STRING: ENSP00000338127
    GRB2P629933I2D: score=1 
    SOS1Q078893I2D: score=1 
    SPRY2O435973I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development NAS9458049
    GO:0009966regulation of signal transduction IEA--

    SPRY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRY3 (SPY3)

    Search CenterWatch for drugs/clinical trials and news about SPRY3 / SPY3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRY3 gene: 
    NM_005840.1  

    Unigene Cluster for SPRY3:

    Sprouty homolog 3 (Drosophila)
    Hs.381912  [show with all ESTs]
    Unigene Representative Sequence: NM_005840
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000302805(uc004fnq.1)
    miRNA
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    8/188 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY3 (see all 188):
    hsa-miR-576-3p hsa-miR-579 hsa-miR-520f hsa-miR-3938 hsa-miR-128 hsa-miR-1245 hsa-miR-3074-3p hsa-miR-342-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY3

    Additional mRNA sequence: 

    AF041038.1 AK094610.1 AK125483.1 AK289543.1 AK311508.1 BC069609.1 BC074972.2 BC074973.2 

    5 DOTS entries:

    DT.110016  DT.120654065  DT.120654064  DT.40286527  DT.91907383 

    24/34 AceView cDNA sequences (see all 34):

    BC074972 N52233 BU164699 BC069609 H24223 NM_005840 BC074973 BQ228300 
    AA682860 BM932153 AA933967 BX115815 BU685186 AI754212 AA650036 BQ012402 
    BM311383 AA994998 AK125483 R42219 T66756 AF041038 AI038709 AK094610 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRY3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAAGCCAAG
    SPRY3 Expression
    About this image


    See SPRY3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRY3

    SOURCE GeneReport for Unigene cluster: Hs.381912

    UniProtKB/Swiss-Prot: SPY3_HUMAN, O43610
    Tissue specificity: Widely expressed; particularly in the fetal tissues

        SABiosciences Custom PCR Arrays for SPRY3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPRY3 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spry31 sprouty homolog 3 (Drosophila) 91.67(n)
    93.4(a)
      236576  NM_001030293.2  NP_001025464.1 
    chicken
    (Gallus gallus)
    Aves SPRY31 sprouty homolog 3 (Drosophila) 70.7(n)
    66.55(a)
      428712  NM_001079736.1  NP_001073204.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPRY36
    Uncharacterized protein
    60(a)
    1 ↔ 1
    GL343202.1(2023560-2024420)
    zebrafish
    (Danio rerio)
    Actinopterygii wufk66h112 Transcribed sequence with moderate similarity to protein more 75.45(n)    57092611 
    fruit fly
    (Drosophila melanogaster)
    Insecta sty6
    sprouty
    15(a)
    1 → many
    3L(3401137-3424935)


    ENSEMBL Gene Tree for SPRY3 (if available)
    TreeFam Gene Tree for SPRY3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPRY3 gene
    SPRY12  SPRY42  SPRY22  
    3 SIMAP similar genes for SPRY3 using alignment to 1 protein entry:     SPY3_HUMAN:
    SPRY2    SPRY4    SPRY1

    SPRY3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in SPRY3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0345194
    ----see VAR_0345192 A T mis40--------

    HapMap Linkage Disequilibrium report for SPRY3 (154997451 - 155012121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPRY3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657377CNV Deletion23128226
    nsv471607CNV Gain+Loss15918152


    Human Gene Mutation Database (HGMD): SPRY3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRY3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRY3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPRY3 for disorders           About MalaCards
    OMIM gene information: 300531    OMIM disorders: --


    SPRY3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPRY3
    Human Genome Epidemiology (HuGE) Navigator: SPRY3 (1 document)

    Export disorders for SPRY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRY3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with SPRY3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)1, 2, 3 Hacohen N.... Krasnow M.A. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. (PubMed id 10655549)1, 2 Ciccodicola A.... D'Urso M. (2000)
    5. SPRED1 mutations (Legius syndrome): another clinicall y useful genotype for dissecting the neurofibromatosis type 1 phenotype. (PubMed id 19443465)4 Spurlock G....Upadhyaya M. (2009)
    6. Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. (PubMed id 17974561)1 Chandramouli S....Guy G.R. (2008)
    7. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    8. A functional interaction between sprouty proteins and caveolin-1. (PubMed id 16877379)1 Cabrita M.A....Christofori G. (2006)
    9. Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. (PubMed id 16500999)1 De Bonis M.L....D'Esposito M. (2006)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10251 HGNC: 11271 AceView: SPRY3 Ensembl:ENSG00000168939 euGenes: HUgn10251
    ECgene: SPRY3 H-InvDB: SPRY3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRY3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPRY3 gene:
    Search GeneIP for patents involving SPRY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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