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Aliases for SPRY3 Gene

Aliases for SPRY3 Gene

  • Sprouty RTK Signaling Antagonist 3 2 3 5
  • Antagonist Of FGF Signaling 2 3
  • Spry-3 3 4
  • Sprouty (Drosophila) Homolog 2 2
  • Sprouty Homolog 3 (Drosophila) 2
  • Sprouty Homolog 3 3

External Ids for SPRY3 Gene

Previous GeneCards Identifiers for SPRY3 Gene

  • GC00U990472
  • GC0YM050220
  • GC0XP153429
  • GC0YP057438
  • GC0XP154561
  • GC0XP154650
  • GC0XP154997
  • GC0XP143477

Summaries for SPRY3 Gene

GeneCards Summary for SPRY3 Gene

SPRY3 (Sprouty RTK Signaling Antagonist 3) is a Protein Coding gene. An important paralog of this gene is SPRY2.

UniProtKB/Swiss-Prot for SPRY3 Gene

  • May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Gene Wiki entry for SPRY3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY3 Gene

Genomics for SPRY3 Gene

Regulatory Elements for SPRY3 Gene

Promoters for SPRY3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPRY3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPRY3 Gene

155,610,950 bp from pter
155,782,459 bp from pter
171,510 bases
Plus strand

Genomic View for SPRY3 Gene

Genes around SPRY3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRY3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY3 Gene

Proteins for SPRY3 Gene

  • Protein details for SPRY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sprouty homolog 3
    Protein Accession:
    Secondary Accessions:
    • A8K0H8

    Protein attributes for SPRY3 Gene

    288 amino acids
    Molecular mass:
    31222 Da
    Quaternary structure:
    No Data Available
    • The gene coding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.
    • Sequence=AAC39567.1; Type=Frameshift; Positions=96; Evidence={ECO:0000305};

neXtProt entry for SPRY3 Gene

Proteomics data for SPRY3 Gene at MOPED

Post-translational modifications for SPRY3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRY3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRY3 Gene

Domains & Families for SPRY3 Gene

Gene Families for SPRY3 Gene

Protein Domains for SPRY3 Gene


Suggested Antigen Peptide Sequences for SPRY3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Belongs to the sprouty family.
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Contains 1 SPR (sprouty) domain.
  • Belongs to the sprouty family.
genes like me logo Genes that share domains with SPRY3: view

Function for SPRY3 Gene

Molecular function for SPRY3 Gene

UniProtKB/Swiss-Prot Function:
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
UniProtKB/Swiss-Prot Induction:
By FGF signaling.
genes like me logo Genes that share phenotypes with SPRY3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPRY3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRY3 Gene

Localization for SPRY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY3 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Subcellular locations from

Jensen Localization Image for SPRY3 Gene COMPARTMENTS Subcellular localization image for SPRY3 gene
Compartment Confidence
cytosol 4
plasma membrane 3
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SPRY3 Gene

Pathways & Interactions for SPRY3 Gene

SuperPathways for SPRY3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA,NAS 9458049
genes like me logo Genes that share ontologies with SPRY3: view

No data available for Pathways by source and SIGNOR curated interactions for SPRY3 Gene

Drugs & Compounds for SPRY3 Gene

No Compound Related Data Available

Transcripts for SPRY3 Gene

Unigene Clusters for SPRY3 Gene

Sprouty homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY3 Gene

No ASD Table

Relevant External Links for SPRY3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRY3 Gene

mRNA expression in normal human tissues for SPRY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRY3 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3) and Brain - Cerebellar Hemisphere (x4.2).

SOURCE GeneReport for Unigene cluster for SPRY3 Gene Hs.381912

mRNA Expression by UniProt/SwissProt for SPRY3 Gene

Tissue specificity: Widely expressed; particularly in the fetal tissues.
genes like me logo Genes that share expression patterns with SPRY3: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SPRY3 Gene

Orthologs for SPRY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPRY3 35
  • 92.59 (n)
  • 96.53 (a)
SPRY3 36
  • 97 (a)
(Canis familiaris)
Mammalia SPRY3 35
  • 95.25 (n)
  • 97.92 (a)
(Mus musculus)
Mammalia Spry3 35
  • 91.67 (n)
  • 93.4 (a)
Spry3 16
Spry3 36
  • 92 (a)
(Pan troglodytes)
Mammalia SPRY3 35
  • 99.65 (n)
  • 99.3 (a)
(Rattus norvegicus)
Mammalia Spry3 35
  • 83.81 (n)
  • 84.53 (a)
(Monodelphis domestica)
Mammalia SPRY3 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia SPRY3 36
  • 57 (a)
(Gallus gallus)
Aves SPRY3 35
  • 70.94 (n)
  • 66.55 (a)
SPRY3 36
  • 60 (a)
(Anolis carolinensis)
Reptilia SPRY3 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spry3 35
  • 63.73 (n)
  • 60.21 (a)
(Danio rerio)
Actinopterygii LOC100003704 35
  • 62.26 (n)
  • 56.98 (a)
wufk66h11 35
fruit fly
(Drosophila melanogaster)
Insecta sty 36
  • 16 (a)
Species with no ortholog for SPRY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRY3 Gene

Gene Tree for SPRY3 (if available)
Gene Tree for SPRY3 (if available)

Paralogs for SPRY3 Gene

Paralogs for SPRY3 Gene

(3) SIMAP similar genes for SPRY3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPRY3: view

Variants for SPRY3 Gene

Sequence variations from dbSNP and Humsavar for SPRY3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_034519 -
rs487307 -- 155,636,194(-) tgatt(C/T)ttggt intron-variant
rs488777 -- 155,677,244(+) GGAGA(C/T)ATAGA intron-variant
rs491636 -- 155,651,006(+) TGTAC(C/T)ATTTT intron-variant
rs491661 -- 155,651,008(+) TACTA(A/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRY3 Gene

Variant ID Type Subtype PubMed ID
esv2657377 CNV Deletion 23128226
nsv471607 CNV Gain+Loss 15918152

Variation tolerance for SPRY3 Gene

Residual Variation Intolerance Score: 67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRY3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRY3 Gene

Disorders for SPRY3 Gene

Relevant External Links for SPRY3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPRY3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRY3 Gene

Publications for SPRY3 Gene

  1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N. … Krasnow M.A. (Cell 1998) 2 3 4 67
  2. Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. (PMID: 17974561) Chandramouli S. … Guy G.R. (J. Biol. Chem. 2008) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Maintenance of X- and Y-inactivation of the pseudoautosomal (PAR2) gene SPRY3 is independent from DNA methylation and associated to multiple layers of epigenetic modifications. (PMID: 16500999) De Bonis M.L. … D'Esposito M. (Hum. Mol. Genet. 2006) 3
  5. A functional interaction between sprouty proteins and caveolin-1. (PMID: 16877379) Cabrita M.A. … Christofori G. (J. Biol. Chem. 2006) 3

Products for SPRY3 Gene

Sources for SPRY3 Gene

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