Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SPRY2 Gene

protein-coding   GIFtS: 66
GCID: GC13M080910

Sprouty Homolog 2 (Drosophila)

(Previous name: sprouty (Drosophila) homolog 2)
  See SPRY2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sprouty Homolog 2 (Drosophila)1 2     Sprouty 22
Sprouty (Drosophila) Homolog 21     spry-22
hSPRY22     Spry-23
Protein Sprouty Homolog 22     

External Ids:    HGNC: 112701   Entrez Gene: 102532   Ensembl: ENSG000001361587   OMIM: 6024665   UniProtKB: O435973   

Export aliases for SPRY2 gene to outside databases

Previous GC identifers: GC13M078877 GC13M074905 GC13M079846 GC13M078708 GC13M079808 GC13M061613


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SPRY2 Gene:
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal
cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is
required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal
endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein
is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling.
The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a
bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein
may play a role in alveoli branching during lung development as shown by a similar mouse protein. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SPRY2 Gene:
SPRY2 (sprouty homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with SPRY2 include legius syndrome, and thanatophoric dysplasia. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRY3.

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597
Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
respiratory organogenesis

Gene Wiki entry for SPRY2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPRY2 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Nkx2-5   SREBP-1b   POU2F2   MZF-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRY2 promoter sequence
   Search Chromatin IP Primers for SPRY2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

SPRY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M080910:  view genomic region     (about GC identifiers)

Start:
80,910,111 bp from pter      End:
80,915,086 bp from pter
Size:
4,976 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597 (See protein sequence)
Recommended Name: Protein sprouty homolog 2  
Size: 315 amino acids; 34688 Da
Subunit: Interacts with RAF1
2 PDB 3D structures from and Proteopedia for SPRY2:
3BUM (3D)        3OB1 (3D)    
Secondary accessions: Q5T6Z7

Explore the universe of human proteins at neXtProt for SPRY2: NX_O43597

Explore proteomics data for SPRY2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPRY2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005833.1  
    ENSEMBL proteins: 
     ENSP00000366306   ENSP00000366308   ENSP00000439027  
    Reactome Protein details: O43597

    SPRY2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SPRY2
    OriGene Protein Over-expression Lysate for SPRY2
    OriGene MassSpec for SPRY2
    OriGene Custom Protein Services for SPRY2
    GenScript Custom Purified and Recombinant Proteins Services for SPRY2
    Novus Biologicals SPRY2 Protein
    Novus Biologicals SPRY2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPRY2

     
    Search eBioscience for Proteins for SPRY2 

    SPRY2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SPRY2
    R&D Systems Antibodies for SPRY2
    OriGene Antibodies for SPRY2
    OriGene Custom Antibody Services for SPRY2
    Novus Biologicals SPRY2 Antibodies
    Abcam antibodies for SPRY2
    Cloud-Clone Corp. Antibodies for SPRY2
    ThermoFisher Antibodies for SPRY2
    LSBio Antibodies in human, mouse, rat for SPRY2

    SPRY2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPRY2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPRY2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPRY2
    Cloud-Clone Corp. CLIAs for SPRY2
    Search eBioscience for ELISAs for SPRY2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007875 Sprouty

    Graphical View of Domain Structure for InterPro Entry O43597

    ProtoNet protein and cluster: O43597

    1 Blocks protein domain: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597
    Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
    Similarity: Belongs to the sprouty family
    Similarity: Contains 1 SPR (sprouty) domain


    Find genes that share domains with SPRY2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPY2_HUMAN, O43597
    Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
    respiratory organogenesis
    Induction: By FGF signaling

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12815057
    GO:0019901protein kinase binding IPI--
    GO:0030291protein serine/threonine kinase inhibitor activity IC--
    GO:0043539protein serine/threonine kinase activator activity IMP18070883
         
    Find genes that share ontologies with SPRY2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPRY2:
     Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Spry2):
     craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  nervous system  reproductive system  respiratory system 
     tumorigenesis  vision/eye 

    Find genes that share phenotypes with SPRY2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SPRY2: Spry2tm1Ayos Spry2tm1.1Mrt

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRY2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPRY2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRY2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRY2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPRY2:
    hsa-mir-181a-5p (MIRT025117), hsa-mir-1 (MIRT023487), hsa-mir-21-5p (MIRT000672), hsa-mir-26b-5p (MIRT028756), hsa-mir-124-3p (MIRT022159), hsa-mir-148a-3p (MIRT025980), hsa-mir-27a-3p (MIRT005511)

    Block miRNA regulation of human, mouse, rat SPRY2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRY2 (see all 44):
    hsa-miR-607 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPRY2
    Predesigned siRNA for gene silencing in human, mouse, rat SPRY2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPRY2

    Clone
    Products:
         
    OriGene clones in human, mouse for SPRY2 (see all 6)
    OriGene ORF clones in mouse, rat for SPRY2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRY2 (NM_005842)
    Sino Biological Human cDNA Clone for SPRY2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPRY2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPRY2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    SPY2_HUMAN, O43597: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules
    in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth
    factor)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol4
    endosome1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0032587ruffle membrane IEA--

    Find genes that share ontologies with SPRY2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SPRY2 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by FGFR0.91
    Signaling by EGFR0.83
    Signaling by FGFR in disease0.91
    Signaling by EGFR in Cancer0.82
    2FGFR ligand binding and activation
    Negative regulation of FGFR signaling0.56
    Spry regulation of FGF signaling0.00
    3Signaling by GPCR
    Signal Transduction0.58
    4Glioma
    Signaling Pathways in Glioblastoma0.36
    5Prostate Cancer
    Prostate Cancer0.32


    Find genes that share SuperPaths with SPRY2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for SPRY2 (see all 6)
        EGFR1 Signaling Pathway
    Signaling Pathways in Glioblastoma
    Prostate Cancer
    FGF signaling pathway
    Internalization of ErbB1


    2 Reactome Pathways for SPRY2
        Spry regulation of FGF signaling
    EGFR downregulation


    2 Kegg Pathways  (Kegg details for SPRY2):
        Jak-STAT signaling pathway
    MicroRNAs in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRY2
    Interactions:

        GeneGlobe Interaction Network for SPRY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPRY2 (O435971, 2, 3 ENSP000003663064) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226811, 2, 3, ENSP000002640334EBI-742487,EBI-518228 MINT-6539050 MINT-6539113 MINT-6170575 MINT-6539098 MINT-6539601 MINT-6538989 MINT-6538901 MINT-6539083 MINT-6169721 MINT-6170624 MINT-6539143 MINT-6539038 MINT-8030771 MINT-6539128 MINT-6170593 MINT-6169688 MINT-6539063 I2D: score=4 STRING: ENSP00000264033
    SH3KBP1Q96B971, 2, 3, ENSP000003809214EBI-742487,EBI-346595 MINT-6170603 MINT-6170575 MINT-6170624 I2D: score=1 STRING: ENSP00000380921
    CSTBP040802, 3, ENSP000002915684MINT-8271982 I2D: score=2 STRING: ENSP00000291568
    NUBP1P533842, 3, ENSP000002830274MINT-8272039 I2D: score=2 STRING: ENSP00000283027
    SDHBP219122, 3, ENSP000003646494MINT-8272050 I2D: score=2 STRING: ENSP00000364649
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007275multicellular organismal development ----
    GO:0007605sensory perception of sound IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with SPRY2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRY2 (SPY2)

    1 Novoseek inferred chemical compound relationship for SPRY2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 54.6 12 12593796 (3), 17510316 (1), 19458088 (1), 19553596 (1) (see all 7)



    Find genes that share compounds with SPRY2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SPRY2 gene: 
    NM_005842.2  

    Unigene Cluster for SPRY2:

    Sprouty homolog 2 (Drosophila)
    Hs.18676  [show with all ESTs]
    Unigene Representative Sequence: BX648582
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377102(uc001vli.3) ENST00000377104(uc001vlj.3) ENST00000540649

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPRY2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRY2 (see all 44):
    hsa-miR-607 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPRY2
    Predesigned siRNA for gene silencing in human, mouse, rat SPRY2
    Clone
    Products:
         
    OriGene clones in human, mouse for SPRY2 (see all 6)
    OriGene ORF clones in mouse, rat for SPRY2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRY2 (NM_005842)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPRY2
    OriGene qSTAR qPCR primer pairs in human, mouse for SPRY2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPRY2
      QuantiTect SYBR Green Assays in human, mouse, rat SPRY2
      QuantiFast Probe-based Assays in human, mouse, rat SPRY2

    Additional mRNA sequence: 

    AF039843.1 AK313810.1 AL713749.1 BC004205.2 BC015745.1 BX648582.1 

    5 DOTS entries:

    DT.115967  DT.100773495  DT.92424395  DT.99945518  DT.100773497 

    Selected AceView cDNA sequences (see all 126):

    BM788302 BF062867 BU177673 AI373921 AI948693 AA443841 BQ183500 BQ446438 
    AA443699 BM680574 BE270351 BQ716297 BM703395 BU731049 BF440014 CD366243 
    AI333308 BQ005097 BQ575215 NM_005842 BG055247 CD678078 CA421275 AI679961 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPRY2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:        -     -     -     -                     
    SP2:              -     -     -                     
    SP3:                          -                     
    SP4:                                                


    ECgene alternative splicing isoforms for SPRY2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SPRY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATTGTAC
    SPRY2 Expression
    About this image


    SPRY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Lens Placode Cells Lens Placode
     
     Somite (Muscoskeletal System)    fully expand to see all 3 entries
             Tendon Progenitor Cells Syndetome
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Cervical Hypaxial Myotome
     
     Epithelial Cells
             Primary Lens Fiber Cells Lens
     
     Tendon & Ligament
             Tendon Progenitor Cells Syndetome
    SPRY2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRY2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18676
        Custom PCR Arrays for SPRY2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPRY2
    OriGene qSTAR qPCR primer pairs in human, mouse for SPRY2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPRY2
    QuantiTect SYBR Green Assays in human, mouse, rat SPRY2
    QuantiFast Probe-based Assays in human, mouse, rat SPRY2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SPRY2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spry21 , 5 sprouty homolog 2 (Drosophila)1, 5 91.93(n)1
    96.82(a)1
      14 (56.16 cM)5
    240641  NM_011897.31  NP_036027.11 
     1058919495 
    chicken
    (Gallus gallus)
    Aves SPRY21 sprouty homolog 2 (Drosophila) 80.62(n)
    85.94(a)
      395584  NM_204800.1  NP_990131.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPRY26
    sprouty homolog 2 (Drosophila)
    81(a)
    1 ↔ 1
    3(96689658-96690599)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983132 sprouty 2 74.89(n)    AF369901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD605806.12   -- 92.36(n)    CD605806.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sty3 negative regulation of EGF receptor
    signaling pathway less
    53(a)   63D2   --


    ENSEMBL Gene Tree for SPRY2 (if available)
    TreeFam Gene Tree for SPRY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SPRY2 gene
    SPRY32  SPRY12  SPRY42  
    3 SIMAP similar genes for SPRY2 using alignment to 1 protein entry:     SPY2_HUMAN:
    SPRY3    SPRY1    SPRY4

    Find genes that share paralogs with SPRY2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SPRY2 (see all 148)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73293431,2
    C,F,H--80909769(+) AAGGAA/CAGTCT 1 -- ds500111Minor allele frequency- C:0.03NS EA NA CSA WA 1204
    rs714365581,2
    C,F--80909789(+) AAGATT/ATAAAA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs716841031,2
    C--80909847(+) TCTGC-/AAAAAAAA 1 -- ds50010--------
    rs2013836351,2
    C--80909864(+) GGGGGG/TGGGGG 1 -- ds50010--------
    rs1917219021,2
    --80909905(+) TCCCAG/TATAAG 1 -- ds50010--------
    rs1830008591,2
    --80909920(+) GATAGA/TAAGTT 1 -- ds50010--------
    rs19285731,2
    C,F,A,H--80909943(-) TTCTAG/ACAATC 1 -- ds500120Minor allele frequency- A:0.11EA NA NS 3726
    rs1424892191,2
    --80910014(+) ATAGAC/GAAGTG 1 -- ds50010--------
    rs95454071,2
    C,F,H--80910052(+) TTAACA/CTAAAA 1 -- ds50014Minor allele frequency- C:0.01NS EA 364
    rs1395138021,2
    --80910156(+) ACATAG/TGCATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SPRY2 (80910111 - 80915086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPRY2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2747714CNV Deletion23290073
    nsv819288CNV Loss19587683
    nsv832660CNV Gain17160897

    Human Gene Mutation Database (HGMD): SPRY2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRY2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602466    OMIM disorders: --

    2 diseases for SPRY2:    
    About MalaCards
    legius syndrome    thanatophoric dysplasia


    Find genes that share disorders with SPRY2           About GenesLikeMe

    1 Novoseek inferred disease relationship for SPRY2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 17510316 (2), 19147787 (1)

    Genetic Association Database (GAD): SPRY2
    Human Genome Epidemiology (HuGE) Navigator: SPRY2 (6 documents)

    Export disorders for SPRY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SPRY2 gene, integrated from 10 sources (see all 136):
    (articles sorted by number of sources associating them with SPRY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)1, 2, 3 Hacohen N.... Krasnow M.A. (Cell 1998)
    2. Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. (PubMed id 10887178)1, 2, 9 Lim J.... Guy G.R. (J. Biol. Chem. 2000)
    3. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. (PubMed id 21706003)1, 4 KilpelAoinen T.O....Loos R.J. (Nat. Genet. 2011)
    4. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (Eur. J. Oral Sci. 2010)
    5. Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. (PubMed id 20023658)1, 4 Mangold E....NAPthen M.M. (Nat. Genet. 2010)
    6. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (PLoS ONE 2010)
    7. Search for pathogenetic variants of the SPRY2 gene in intestinal innervation defects. (PubMed id 19545245)1, 4 Borghini S....Ceccherini I. (Intern Med J 2009)
    8. Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)1, 4 Vieira A.R.... Murray J.C. (PLoS Genet. 2005)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10253 HGNC: 11270 AceView: SPRY2 Ensembl:ENSG00000136158 euGenes: HUgn10253
    ECgene: SPRY2 Kegg: 10253 H-InvDB: SPRY2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SPRY2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPRY2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SPRY2 gene:
    Search GeneIP for patents involving SPRY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of SPRY2
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for SPRY2 (SPRY2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SPRY2   OriGene RNAi products in human, mouse, rat for SPRY2  
     OriGene qPCR primer pairs and template standards for SPRY2   OriGene Protein Over-expression Lysate for SPRY2  
     OriGene MassSpec something-or-other for SPRY2   OriGene clones in human, mouse for SPRY2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPRY2   OriGene Purified Protein for SPRY2  
     OriGene ORF clones in mouse, rat for SPRY2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPRY2   OriGene Custom Protein Services for SPRY2  

     
     
     Block miRNA regulation of human, mouse, rat SPRY2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPRY2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRY2 Predesigned siRNA for gene silencing in human, mouse, rat SPRY2
     QuantiFast Probe-based Assays in human, mouse, rat SPRY2 QuantiTect SYBR Green Assays in human, mouse, rat SPRY2
     Custom PCR Arrays for SPRY2 Search Chromatin IP Primers for SPRY2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPRY2  GeneGlobe Interaction Network for SPRY2
     Regulatory tfbs in SPRY2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SPRY2 GenScript cDNA clones with any tag delivered in your preferred vector for SPRY2
     GenScript Custom Assay Services for SPRY2 GenScript Custom overexpressing Cell Line Services for SPRY2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SPRY2 (SPY2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SPRY2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SPRY2 antibodies
     SPRY2 proteins
     SPRY2 lysates
     Antibodies for SPRY2
     See all of Abcam's Antibodies, Kits and Proteins for SPRY2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SPRY2
     Antibodies for SPRY2
     ELISAs for SPRY2
     CLIAs for SPRY2



     Browse ESI BIO Cell Lines and PureStem Progenitors for SPRY2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY2
     SwitchGear 3'UTR luciferase reporter plasmids for SPRY2
     SwitchGear Promoter luciferase reporter plasmids for SPRY2
     ThermoFisher Antibodies for SPRY2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRY2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPRY2
     LSBio Antibodies in human, mouse, rat for SPRY2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SPRY2
      Search eBioscience for proteins for SPRY2
      Search eBioscience for elisas for SPRY2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPRY2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4