Aliases for SPRY2 Gene
External Ids for SPRY2 Gene
Previous GeneCards Identifiers for SPRY2 Gene
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for SPRY2 Gene
SPRY2 (Sprouty RTK Signaling Antagonist 2) is a Protein Coding gene. Diseases associated with SPRY2 include adrenal cortical adenocarcinoma and thanatophoric dysplasia, type ii. Among its related pathways are Signaling by GPCR and Negative regulation of FGFR3 signaling. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRY3.
UniProtKB/Swiss-Prot for SPRY2 Gene
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.