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Aliases for SPRY2 Gene

Aliases for SPRY2 Gene

  • Sprouty Homolog 2 (Drosophila) 2 3
  • Spry-2 3 4
  • Sprouty (Drosophila) Homolog 2 2
  • Protein Sprouty Homolog 2 3
  • Sprouty 2 3
  • HSPRY2 3

External Ids for SPRY2 Gene

Previous GeneCards Identifiers for SPRY2 Gene

  • GC13M078877
  • GC13M074905
  • GC13M079846
  • GC13M078708
  • GC13M079808
  • GC13M080910
  • GC13M061613

Summaries for SPRY2 Gene

Entrez Gene Summary for SPRY2 Gene

  • This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPRY2 Gene

SPRY2 (Sprouty Homolog 2 (Drosophila)) is a Protein Coding gene. Diseases associated with SPRY2 include thanatophoric dysplasia, type ii and legius syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRY3.

UniProtKB/Swiss-Prot for SPRY2 Gene

  • May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Gene Wiki entry for SPRY2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY2 Gene

Genomics for SPRY2 Gene

Regulatory Elements for SPRY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPRY2 Gene

80,335,976 bp from pter
80,340,968 bp from pter
4,993 bases
Minus strand

Genomic View for SPRY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY2 Gene

Proteins for SPRY2 Gene

  • Protein details for SPRY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sprouty homolog 2
    Protein Accession:
    Secondary Accessions:
    • B2R9J9
    • Q5T6Z7

    Protein attributes for SPRY2 Gene

    315 amino acids
    Molecular mass:
    34688 Da
    Quaternary structure:
    • Interacts with RAF1.

    Three dimensional structures from OCA and Proteopedia for SPRY2 Gene

neXtProt entry for SPRY2 Gene

Proteomics data for SPRY2 Gene at MOPED

Post-translational modifications for SPRY2 Gene

  • Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRY2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SPRY2 (SPRY2)

No data available for DME Specific Peptides for SPRY2 Gene

Domains for SPRY2 Gene

Protein Domains for SPRY2 Gene


Suggested Antigen Peptide Sequences for SPRY2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O43597
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Contains 1 SPR (sprouty) domain.
  • Belongs to the sprouty family.
genes like me logo Genes that share domains with SPRY2: view

No data available for Gene Families for SPRY2 Gene

Function for SPRY2 Gene

Molecular function for SPRY2 Gene

UniProtKB/Swiss-Prot Function:
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
UniProtKB/Swiss-Prot Induction:
By FGF signaling

Gene Ontology (GO) - Molecular Function for SPRY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12815057
GO:0019901 protein kinase binding IPI 20736167
GO:0030291 protein serine/threonine kinase inhibitor activity IC 20736167
GO:0043539 protein serine/threonine kinase activator activity IMP 18070883
genes like me logo Genes that share ontologies with SPRY2: view
genes like me logo Genes that share phenotypes with SPRY2: view

Animal Models for SPRY2 Gene

MGI Knock Outs for SPRY2:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRY2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPRY2 Gene

Localization for SPRY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY2 Gene

Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor).

Subcellular locations from

Jensen Localization Image for SPRY2 Gene COMPARTMENTS Subcellular localization image for SPRY2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SPRY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
GO:0005886 plasma membrane TAS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SPRY2: view

Pathways for SPRY2 Gene

genes like me logo Genes that share pathways with SPRY2: view

Gene Ontology (GO) - Biological Process for SPRY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007275 multicellular organismal development --
GO:0007605 sensory perception of sound IEA --
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with SPRY2: view

Compounds for SPRY2 Gene

(1) Novoseek inferred chemical compound relationships for SPRY2 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 54.6 9
genes like me logo Genes that share compounds with SPRY2: view

Transcripts for SPRY2 Gene

Unigene Clusters for SPRY2 Gene

Sprouty homolog 2 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRY2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - - -
SP2: - - -
SP3: -

Relevant External Links for SPRY2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRY2 Gene

mRNA expression in normal human tissues for SPRY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SPRY2 Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRY2 Gene

SOURCE GeneReport for Unigene cluster for SPRY2 Gene Hs.18676

genes like me logo Genes that share expressions with SPRY2: view

Expression partners for SPRY2 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPRY2 Gene

Orthologs for SPRY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPRY2 35
  • 88.36 (n)
  • 93.33 (a)
SPRY2 36
  • 93 (a)
(Canis familiaris)
Mammalia SPRY2 35
  • 93.97 (n)
  • 97.14 (a)
SPRY2 36
  • 96 (a)
(Mus musculus)
Mammalia Spry2 35
  • 91.93 (n)
  • 96.82 (a)
Spry2 16
Spry2 36
  • 94 (a)
(Pan troglodytes)
Mammalia SPRY2 35
  • 99.89 (n)
  • 100 (a)
SPRY2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Spry2 35
  • 92.14 (n)
  • 95.54 (a)
(Monodelphis domestica)
Mammalia SPRY2 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia SPRY2 36
  • 75 (a)
(Gallus gallus)
Aves SPRY2 35
  • 80.62 (n)
  • 85.94 (a)
SPRY2 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SPRY2 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spry2 35
  • 72.31 (n)
  • 74.76 (a)
Str.92 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398313 35
(Danio rerio)
Actinopterygii spry2 35
  • 62.86 (n)
  • 61.43 (a)
spry2 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta sty 37
  • 53 (a)
sty 36
  • 15 (a)
Species with no ortholog for SPRY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRY2 Gene

Gene Tree for SPRY2 (if available)
Gene Tree for SPRY2 (if available)

Paralogs for SPRY2 Gene

Paralogs for SPRY2 Gene

Selected SIMAP similar genes for SPRY2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPRY2: view

Variants for SPRY2 Gene

Sequence variations from dbSNP and Humsavar for SPRY2 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs4728 -- 80,336,651(-) GAAAG(G/T)TGGGA utr-variant-3-prime
rs11911 -- 80,336,716(-) TTTCT(G/T)TCTTT utr-variant-3-prime
rs485183 -- 80,339,303(+) CACAC(A/G)GCGAC intron-variant, utr-variant-5-prime
rs504122 - 80,337,390(-) GAGCC(A/C/G/T)CTCTG missense, reference
rs563692 -- 80,337,966(-) TGTAC(A/G)TCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRY2 Gene

Variant ID Type Subtype PubMed ID
esv2747714 CNV Deletion 23290073
nsv832660 CNV Gain 17160897
nsv819288 CNV Loss 19587683

Relevant External Links for SPRY2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRY2 Gene

Disorders for SPRY2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SPRY2 Gene in MalaCards »

(2) Diseases for SPRY2 Gene including...

(1) Novoseek inferred disease relationships for SPRY2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 3

Relevant External Links for SPRY2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPRY2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for SPRY2 Gene

Publications for SPRY2 Gene

  1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N. … Krasnow M.A. (Cell 1998) 2 3 4
  2. Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. (PMID: 10887178) Lim J. … Guy G.R. (J. Biol. Chem. 2000) 3 4 23
  3. Human SPRY2 inhibits FGF2 signalling by a secreted factor. (PMID: 10940627) Glienke J. … Thierauch K.H. (Mech. Dev. 2000) 3 23
  4. HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2. (PMID: 19864419) Edwin F. … Patel T.B. (J. Biol. Chem. 2010) 3 23
  5. Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. (PMID: 12717443) Sasaki A. … Yoshimura A. (Nat. Cell Biol. 2003) 3 4

Products for SPRY2 Gene

Sources for SPRY2 Gene

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