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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPRY2 Gene

protein-coding GIFtS: 66
GCID: GC13M080910

sprouty homolog 2 (Drosophila)

(Previous name: sprouty (Drosophila) homolog 2 )

Explore 23 diseases affiliated with
SPRY2 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Sprouty Homolog 2 (Drosophila)¹ ²		Sprouty 2²
HSPRY2¹		Spry-2³
Sprouty (Drosophila) Homolog 2¹		Spry-2³
Protein Sprouty Homolog 2²

External Ids:	HGNC: 11270¹	Entrez Gene: 10253²	Ensembl: ENSG00000136158⁷	OMIM: 602466⁵	UniProtKB: O43597³

Export aliases for SPRY2 gene to outside databases

Previous GC identifers: GC13M078877 GC13M074905 GC13M079846 GC13M078708 GC13M079808 GC13M061613

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPRY2:

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal

cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is

required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial

cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly

involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts

with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal

growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching

during lung development as shown by a similar mouse protein. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597

Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate

respiratory organogenesis

Gene Wiki entry for SPRY2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPRY2 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 Nkx2-5 SREBP-1b POU2F2 MZF-1 POU2F1 POU2F1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPRY2 promoter sequence

Search SABiosciences Chromatin IP Primers for SPRY2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRY2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1 Ensembl cytogenetic band: 13q31.1 HGNC cytogenetic band: 13q31.1

SPRY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY2 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M080910: view genomic region (about GC identifiers)

Start:	80,910,111 bp from pter	End:	80,915,086 bp from pter
Size:	4,976 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597 (See protein sequence)

Recommended Name: Protein sprouty homolog 2

Size: 315 amino acids; 34688 Da

Subunit: Interacts with RAF1

Subcellular location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in

unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor)

2 PDB 3D structures from and Proteopedia for SPRY2:

3BUM (3D)

3OB1 (3D)

Secondary accessions: Q5T6Z7

Explore the universe of human proteins at neXtProt for SPRY2: NX_O43597

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O43597

SPRY2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005833.1

ENSEMBL proteins:

ENSP00000366308 ENSP00000366306 ENSP00000439027

Reactome Protein details: O43597
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SPRY2 OriGene Protein Over-expression Lysate: SPRY2 OriGene Custom Protein Services for SPRY2
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	Novus Biologicals SPRY2 Protein Novus Biologicals SPRY2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SPRY2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0005874	microtubule	IEA	--
GO:0005886	plasma membrane	TAS	--
GO:0032587	ruffle membrane	IEA	--

SPRY2 for ontologies About GeneDecksing

SPRY2 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SPRY2
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	Novus Biologicals SPRY2 Antibodies
	Search for Antibodies for SPRY2 at Abcam
	Uscn Antibodies for SPRY2
	ThermoFisher Antibodies for SPRY2

Assay Products for SPRY2:

	EMD Millipore Kits and Assays for the Analysis of SPRY2
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SPRY2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SPRY2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPRY2 for domains About GeneDecksing

1 InterPro domain/family:

IPR007875 Sprouty

Graphical View of Domain Structure for InterPro Entry O43597

ProtoNet protein and cluster: O43597

1 Blocks protein family: IPB007875 Sprouty

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597

Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles

Similarity: Belongs to the sprouty family

Similarity: Contains 1 SPR (sprouty) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597

Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate

respiratory organogenesis

Induction: By FGF signaling

miRNA Products:		miRTarBase miRNAs that target SPRY2: hsa-mir-21 (MIRT000672), hsa-mir-27a (MIRT005511)

		OriGene 3'-UTR Clone: SPRY2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY2
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY2 (see all 44):
		hsa-miR-607 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-570 hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: SPRY2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRY2 (see all 7) OriGene shRNA RFP: SPRY2 OriGene siRNA: SPRY2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRY2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SPRY2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SPRY2 (NM_005842)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPRY2
		Search LifeMap BioReagents cell lines for SPRY2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0019901	protein kinase binding	IPI	--
GO:0030291	protein serine/threonine kinase inhibitor activity	IC	--
GO:0043539	protein serine/threonine kinase activator activity	IMP	18070883

SPRY2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for SPRY2:

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for SPRY2: Spry2^tm1Ayos Spry2^tm1.1Mrt
12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Spry2):

craniofacial	digestive/alimentary	endocrine/exocrine gland	growth/size	hearing/vestibular/ear
limbs/digits/tail	mortality/aging	nervous system	reproductive system	respiratory system
tumorigenesis	vision/eye

SPRY2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

	Signaling by FGFR	1.00			Signaling by EGFR	0.84
	Signaling by FGFR in disease	0.91			Signaling by EGFR in Cancer	0.83

Sprouty lures cytosolic CBL away from EGFR

	Sprouty lures cytosolic CBL away from EGFR	1.00			SPRY2 is serine phosphorylated in response to MAPK activation	0.25
	Sprouty lures membrane-bound CBL away from EGFR	1.00

FGFR2c binds to FGF

Negative regulation of FGFR signaling

0.33

Spry regulation of FGF signaling

0.00

Disease

Disease

1.00

Selected targets of CREB1

Selected targets of CREB1

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for SPRY2

Selected targets of CREB1

5 BioSystems Pathways for SPRY2

	Signaling Pathways in Glioblastoma
	EGFR1 Signaling Pathway
	Signaling events mediated by PTP1B
	Internalization of ErbB1
	FGF signaling pathway

5/12 Reactome Pathways for SPRY2 (see all 12)

	Sprouty lures cytosolic CBL away from EGFR
	SPRY2 is serine phosphorylated in response to MAPK activation
	Signaling by EGFR in Cancer
	Signaling by FGFR in disease
	Spry regulation of FGF signaling

1 Kegg Pathway (Kegg details for SPRY2):

Jak-STAT signaling pathway

SPRY2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SPRY2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/74 Interacting proteins for SPRY2 (O43597^{2, 3} ENSP00000366306⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 74)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBL	P22681²^,³, ENSP00000264033⁴	MINT-6539050 MINT-6539113 MINT-6170575 MINT-6539098 MINT-6539601 MINT-6538989 MINT-6538901 MINT-6539083 MINT-6169721 MINT-6170624 MINT-6539143 MINT-6539038 MINT-8030771 MINT-6539128 MINT-6170593 MINT-6169688 MINT-6539063 I2D: score=4 STRING: ENSP00000264033
SH3KBP1	Q96B97²^,³, ENSP00000380921⁴	MINT-6170603 MINT-6170575 MINT-6170624 I2D: score=1 STRING: ENSP00000380921
CSTB	P04080²^,³, ENSP00000291568⁴	MINT-8271982 I2D: score=2 STRING: ENSP00000291568
NUBP1	P53384²^,³, ENSP00000283027⁴	MINT-8272039 I2D: score=2 STRING: ENSP00000283027
SDHB	P21912²^,³, ENSP00000364649⁴	MINT-8272050 I2D: score=2 STRING: ENSP00000364649

About this table

Gene Ontology (GO): 5/26 biological process terms (GO ID links to tree view) (see all 26): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--
GO:0007605	sensory perception of sound	IEA	--
GO:0008285	negative regulation of cell proliferation	IEA	--
GO:0008543	fibroblast growth factor receptor signaling pathway	TAS	--
GO:0010628	positive regulation of gene expression	IMP	18070883

SPRY2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SPRY2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPRY2
1 Novoseek chemical compound relationship for SPRY2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	54.6	12	12593796 (3), 17510316 (1), 19458088 (1), 19553596 (1) (see all 7)

Search CenterWatch for drugs/clinical trials and news about SPRY2 / SPY2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPRY2 gene:

NM_005842.2

Unigene Cluster for SPRY2:

Sprouty homolog 2 (Drosophila)

Hs.18676 [show with all ESTs]

Unigene Representative Sequence: BX648582

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377104(uc001vlj.3) ENST00000377102(uc001vli.3) ENST00000540649

miRNA Products:		OriGene 3'-UTR Clone: SPRY2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY2
		8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY2 (see all 44):
		hsa-miR-607 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-570 hsa-miR-124

		SwitchGear 3'UTR luciferase reporter plasmid: SPRY2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRY2 (see all 7) OriGene shRNA RFP: SPRY2 OriGene siRNA: SPRY2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRY2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: SPRY2 (NM_005842)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRY2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPRY2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRY2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY2

Additional cDNA sequence:

AF039843.1 AK313810.1 AL713749.1 BC004205.2 BC015745.1 BX648582.1

5 DOTS entries:

DT.115967 DT.100773495 DT.92424395 DT.99945518 DT.100773497

24/126 AceView cDNA sequences (see all 126):

CD678078 CA421275 BM788302 BU177673 AI445358 AI373921 NM_005842 AI948693

BQ005097 BQ889545 AA453759 CR599246 AI193601 CD678077 AI683545 BU731049

BM680574 AI679521 BQ716297 CD366243 AA703183 BF062867 AI679961 AI333308

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SPRY2 About this scheme

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c
SP1:			-		-		-		-
SP2:					-		-		-
SP3:									-
SP4:

ECgene alternative splicing isoforms for SPRY2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPRY2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATTGTAC

About this image

SPRY2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/15 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 15)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Somite

Sacral Syndetome

Tendon Progenitor Cells

Tendons & Ligaments

Lung

Lung Bud

Distal Lung Progenitor Cells

Lung

Lung Bud

Lung Bud Progenitor Cells

Lung

Neural Ectoderm

Extraembryonic Tissues, Placenta

Primitive Streak

Primitive Streak Cells

Early Embryo

Somite

Cervical Epaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Hypaxial Myotome

Mononuclear Myocytes

Skeletal Muscle

Somite

Cervical Syndetome

Tendon Progenitor Cells

Tendons & Ligaments

Somite

Lumbar Syndetome

Tendon Progenitor Cells

Tendons & Ligaments

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPRY2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRY2

SOURCE GeneReport for Unigene cluster: Hs.18676

SABiosciences Custom PCR Arrays for SPRY2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRY2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPRY2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRY2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for SPRY2 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SPRY2¹	sprouty homolog 2 (Drosophila)	80.62(n) 85.94(a)		395584 NM_204800.1 NP_990131.1
lizard (Anolis carolinensis)	Reptilia	SPRY2⁶	--	82(a)	1 ↔ 1	3(96689658-96690599)
African clawed frog (Xenopus laevis)	Amphibia	LOC398313²	sprouty 2	74.89(n)		AF369901.1
zebrafish (Danio rerio)	Actinopterygii	CD605806.1²	--	92.36(n)		CD605806.1
fruit fly (Drosophila melanogaster)	Insecta	sty³	negative regulation of EGF receptor signaling pathway less	53(a)		63D2 --

ENSEMBL Gene Tree for SPRY2 (if available)
TreeFam Gene Tree for SPRY2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPRY2 gene

SPRY3² SPRY1² SPRY4²

3 SIMAP similar genes for SPRY2 using alignment to 1 protein entry: SPY2_HUMAN:

SPRY3 SPRY1 SPRY4

SPRY2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7329343^1,2	C,F,H,	--	80909769(+)	`AAGGAA/CAGTCT`	1	--	ds500¹		11		NS EA NA CSA WA	1204
rs71436558^1,2	C,	--	80909789(+)	`AAGATT/ATAAAA`	1	--	ds500¹		1		NA	2
rs11391235^1,2	C	--	80909847(+)	`AAAAAA/-GGGGG`	1	--	ds500¹		1		NA	2
rs71684103^1,2	C	--	80909847(+)	`TCTGC-/AAAAAAAA`	1	--	ds500¹		0	--	--	--	--
rs191721902^1,2		--	80909905(+)	`TCCCAG/TATAAG`	1	--	ds500¹		0	--	--	--	--
rs183000859^1,2		--	80909920(+)	`GATAGA/TAAGTT`	1	--	ds500¹		0	--	--	--	--
rs1928573^1,2	C,F,A,H,	--	80909943(-)	`TTCTAG/ACAATC`	1	--	ds500¹		20		EA NA NS	3726
rs142489219^1,2		--	80910014(+)	`ATAGAC/GAAGTG`	1	--	ds500¹		0	--	--	--	--
rs9545407^1,2	F,H,	--	80910052(+)	`TTAACA/CTAAAA`	1	--	ds500¹		4		NS EA	364
rs139513802^1,2		--	80910156(+)	`ACATAG/TGCATC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPRY2 (80910111 - 80915086 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPRY2
1 Indel: 58644
Human Gene Mutation Database (HGMD): SPRY2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPRY2 for disorders           About GeneDecksing

OMIM gene information: 602466    OMIM disorders: --

20/23 diseases for SPRY2 (see all 23):    About MalaCards

cleft lip/palate cleft lip thanatophoric dysplasia b-cell lymphomas

cleft palate achondroplasia cblc endometrial carcinoma

liver cancer hepatocellular carcinoma colon cancer periodontitis

pancreatic cancer prostate carcinoma lung cancer prostatitis

carcinoma prostate cancer pancreatitis sarcoma

1 Novoseek disease relationship for SPRY2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	4	17510316 (2), 19147787 (1)

Genetic Association Database (GAD): SPRY2
Human Genome Epidemiology (HuGE) Navigator: SPRY2 (6 documents)

Export disorders for SPRY2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPRY2 gene, integrated from 9 sources (see all 119):
(articles sorted by number of sources associating them with SPRY2)

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Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)^{1, 2, 3} Hacohen N.... Krasnow M.A. (1998)
Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. (PubMed id 10887178)^{1, 2, 9} Lim J.... Guy G.R. (2000)
Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)^{1, 4} Vieira A.R.... Murray J.C. (2005)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. (PubMed id 12717443)^{1, 2} Sasaki A....Yoshimura A. (2003)
hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. (PubMed id 12593796)^{1, 9} Hall A.B....Bar-Sagi D. (2003)
Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2. (PubMed id 16888801)^{1, 9} Nadeau R.J....Friesel R. (2007)
Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer. (PubMed id 15735753)^{1, 9} McKie A.B....Leung H.Y. (2005)
Direct binding of PP2A to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of fibroblast growth factor receptor stimulation. (PubMed id 17255109)^{1, 9} Lao D.H....Guy G.R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10253	HGNC: 11270	AceView: SPRY2	Ensembl:ENSG00000136158	euGenes: HUgn10253
ECgene: SPRY2	Kegg: 10253	H-InvDB: SPRY2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPRY2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPRY2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for SPRY2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SPRY2 gene:
Search GeneIP for patents involving SPRY2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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sprouty homolog 2 (Drosophila)

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SPRY2 Gene

sprouty homolog 2 (Drosophila)

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