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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRY2 Gene

protein-coding   GIFtS: 67
GCID: GC13M080910

Sprouty Homolog 2 (Drosophila)

(Previous name: sprouty (Drosophila) homolog 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sprouty Homolog 2 (Drosophila)1 2     Sprouty 22
Sprouty (Drosophila) Homolog 21     spry-22
hSPRY22     Spry-23
Protein Sprouty Homolog 22     

External Ids:    HGNC: 112701   Entrez Gene: 102532   Ensembl: ENSG000001361587   OMIM: 6024665   UniProtKB: O435973   

Export aliases for SPRY2 gene to outside databases

Previous GC identifers: GC13M078877 GC13M074905 GC13M079846 GC13M078708 GC13M079808 GC13M061613


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPRY2 Gene:
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal
cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is
required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal
endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein
is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling.
The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a
bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein
may play a role in alveoli branching during lung development as shown by a similar mouse protein. (provided by
RefSeq, Jul 2008)

GeneCards Summary for SPRY2 Gene: 
SPRY2 (sprouty homolog 2 (Drosophila)) is a protein-coding gene. Diseases associated with SPRY2 include cblc, and thanatophoric dysplasia, and among its related super-pathways are Signaling by FGFR and FGFR ligand binding and activation. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRY3.

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597
Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
respiratory organogenesis

Gene Wiki entry for SPRY2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRY2 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   Nkx2-5   SREBP-1b   POU2F2   MZF-1   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRY2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRY2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q31.1   Ensembl cytogenetic band:  13q31.1   HGNC cytogenetic band: 13q31.1

SPRY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY2 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M080910:  view genomic region     (about GC identifiers)

Start:
80,910,111 bp from pter      End:
80,915,086 bp from pter
Size:
4,976 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597 (See protein sequence)
Recommended Name: Protein sprouty homolog 2  
Size: 315 amino acids; 34688 Da
Subunit: Interacts with RAF1
Subcellular location: Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules
in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth
factor)
2 PDB 3D structures from and Proteopedia for SPRY2:
3BUM (3D)        3OB1 (3D)    
Secondary accessions: Q5T6Z7

Explore the universe of human proteins at neXtProt for SPRY2: NX_O43597

Explore proteomics data for SPRY2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43597

  • SPRY2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPRY2 Protein Expression
    REFSEQ proteins: NP_005833.1  
    ENSEMBL proteins: 
     ENSP00000366306   ENSP00000366308   ENSP00000439027  
    Reactome Protein details: O43597
    Human Recombinant Protein Products for SPRY2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals SPRY2 Protein
    Novus Biologicals SPRY2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPRY2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0032587ruffle membrane IEA--

    SPRY2 for ontologies           About GeneDecksing



    SPRY2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SPRY2 

    Assay Products for SPRY2: 
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    Cloud-Clone Corp. ELISAs for SPRY2 
    Cloud-Clone Corp. CLIAs for SPRY2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007875 Sprouty

    Graphical View of Domain Structure for InterPro Entry O43597

    ProtoNet protein and cluster: O43597

    1 Blocks protein domain: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPY2_HUMAN, O43597
    Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
    Similarity: Belongs to the sprouty family
    Similarity: Contains 1 SPR (sprouty) domain


    SPRY2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPY2_HUMAN, O43597
    Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
    respiratory organogenesis
    Induction: By FGF signaling

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12815057
    GO:0019901protein kinase binding IPI--
    GO:0030291protein serine/threonine kinase inhibitor activity IC--
    GO:0043539protein serine/threonine kinase activator activity IMP18070883
         
    SPRY2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPRY2:
     Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Spry2):
     craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  nervous system  reproductive system  respiratory system 
     tumorigenesis  vision/eye 

    SPRY2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SPRY2: Spry2tm1Ayos Spry2tm1.1Mrt

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRY2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPRY2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRY2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRY2 

    miRNA
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    miRTarBase miRNAs that target SPRY2:
    hsa-mir-21 (MIRT000672), hsa-mir-27a (MIRT005511)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY2
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY2 (see all 44):
    hsa-miR-607 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Sino Biological Human cDNA Clone for SPRY2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY2
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                         Customized lentivirus expression plasmids for stable overexpression of SPRY2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPRY2 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by FGFR0.92
    Signaling by EGFR0.84
    Signaling by FGFR in disease0.91
    Signaling by EGFR in Cancer0.83
    2FGFR2c ligand binding and activation
    Negative regulation of FGFR signaling0.57
    Spry regulation of FGF signaling0.35
    3Signaling by GPCR
    Signal Transduction0.55
    4Glioma
    Signaling Pathways in Glioblastoma0.36
    5Prostate Cancer
    Prostate Cancer0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SPRY2
        Selected targets of CREB1


    5/6 BioSystems Pathways for SPRY2 (see all 6)
        EGFR1 Signaling Pathway
    Signaling Pathways in Glioblastoma
    Prostate Cancer
    Signaling events mediated by PTP1B
    Internalization of ErbB1


    5/9        Reactome Pathways for SPRY2 (see all 9)
        Negative regulation of FGFR signaling
    Signaling by FGFR
    Signal Transduction
    Signaling by EGFR in Cancer
    Signaling by EGFR


    2         Kegg Pathways  (Kegg details for SPRY2):
        Jak-STAT signaling pathway
    MicroRNAs in cancer


    SPRY2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPRY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for SPRY2 (O435972, 3 ENSP000003663064) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226812, 3, ENSP000002640334MINT-6539050 MINT-6539113 MINT-6170575 MINT-6539098 MINT-6539601 MINT-6538989 MINT-6538901 MINT-6539083 MINT-6169721 MINT-6170624 MINT-6539143 MINT-6539038 MINT-8030771 MINT-6539128 MINT-6170593 MINT-6169688 MINT-6539063 I2D: score=4 STRING: ENSP00000264033
    SH3KBP1Q96B972, 3, ENSP000003809214MINT-6170603 MINT-6170575 MINT-6170624 I2D: score=1 STRING: ENSP00000380921
    CSTBP040802, 3, ENSP000002915684MINT-8271982 I2D: score=2 STRING: ENSP00000291568
    NUBP1P533842, 3, ENSP000002830274MINT-8272039 I2D: score=2 STRING: ENSP00000283027
    SDHBP219122, 3, ENSP000003646494MINT-8272050 I2D: score=2 STRING: ENSP00000364649
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007275multicellular organismal development ----
    GO:0007605sensory perception of sound IEA--
    GO:0008285negative regulation of cell proliferation IEA--
    GO:0008543fibroblast growth factor receptor signaling pathway TAS--

    SPRY2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPRY2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRY2 (SPY2)

    1 Novoseek inferred chemical compound relationship for SPRY2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 54.6 12 12593796 (3), 17510316 (1), 19458088 (1), 19553596 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about SPRY2 / SPY2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRY2 gene: 
    NM_005842.2  

    Unigene Cluster for SPRY2:

    Sprouty homolog 2 (Drosophila)
    Hs.18676  [show with all ESTs]
    Unigene Representative Sequence: BX648582
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377102(uc001vli.3) ENST00000377104(uc001vlj.3) ENST00000540649

    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY2 (see all 44):
    hsa-miR-607 hsa-miR-330-5p hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-138-2* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRY2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY2

    Additional mRNA sequence: 

    AF039843.1 AK313810.1 AL713749.1 BC004205.2 BC015745.1 BX648582.1 

    5 DOTS entries:

    DT.115967  DT.100773495  DT.92424395  DT.99945518  DT.100773497 

    24/126 AceView cDNA sequences (see all 126):

    BM680574 CD366243 AI193601 BM788302 AI679521 BU177673 CD678077 BQ575215 
    NM_005842 BQ716297 AI445358 BQ005097 BC015745 AI679961 AI373921 BF440014 
    AA443841 AA443699 AI683545 AA703183 BM703395 CR599246 BM684160 CD678078 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPRY2    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:        -     -     -     -                     
    SP2:              -     -     -                     
    SP3:                          -                     
    SP4:                                                


    ECgene alternative splicing isoforms for SPRY2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRY2 expression in normal human tissues (normalized intensities)      SPRY2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATTGTAC
    SPRY2 Expression
    About this image


    SPRY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Somite (Muscoskeletal System)    fully expand to see all 6 entries
             Tendon Progenitor Cells Thoracic Syndetome
     
     Tendon & Ligament
             Tendon Progenitor Cells Thoracic Syndetome
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Distal Lung Progenitor Cells Lung Bud
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             Secondary Enamel Knot Cells Enamel Knot
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Cervical Hypaxial Myotome

    See SPRY2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRY2

    SOURCE GeneReport for Unigene cluster: Hs.18676
        SABiosciences Custom PCR Arrays for SPRY2
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPRY2 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spry21 , 5 sprouty homolog 2 (Drosophila)1, 5 91.93(n)1
    96.82(a)1
      14 (56.16 cM)5
    240641  NM_011897.31  NP_036027.11 
     1058919495 
    chicken
    (Gallus gallus)
    Aves SPRY21 sprouty homolog 2 (Drosophila) 80.62(n)
    85.94(a)
      395584  NM_204800.1  NP_990131.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPRY26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    3(96689658-96690599)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3983132 sprouty 2 74.89(n)    AF369901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CD605806.12   -- 92.36(n)    CD605806.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sty3 negative regulation of EGF receptor
    signaling pathway less
    53(a)   63D2   --


    ENSEMBL Gene Tree for SPRY2 (if available)
    TreeFam Gene Tree for SPRY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPRY2 gene
    SPRY32  SPRY12  SPRY42  
    3 SIMAP similar genes for SPRY2 using alignment to 1 protein entry:     SPY2_HUMAN:
    SPRY3    SPRY1    SPRY4

    SPRY2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/148 SNPs in SPRY2 are shown (see all 148)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73293431,2
    C,F,H--80909769(+) AAGGAA/CAGTCT 1 -- ds500111Minor allele frequency- C:0.03NS EA NA CSA WA 1204
    rs714365581,2
    C,F--80909789(+) AAGATT/ATAAAA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs716841031,2
    C--80909847(+) TCTGC-/AAAAAAAA 1 -- ds50010--------
    rs2013836351,2
    C--80909864(+) GGGGGG/TGGGGG 1 -- ds50010--------
    rs1917219021,2
    --80909905(+) TCCCAG/TATAAG 1 -- ds50010--------
    rs1830008591,2
    --80909920(+) GATAGA/TAAGTT 1 -- ds50010--------
    rs19285731,2
    C,F,A,H--80909943(-) TTCTAG/ACAATC 1 -- ds500120Minor allele frequency- A:0.11EA NA NS 3726
    rs1424892191,2
    --80910014(+) ATAGAC/GAAGTG 1 -- ds50010--------
    rs95454071,2
    C,F,H--80910052(+) TTAACA/CTAAAA 1 -- ds50014Minor allele frequency- C:0.01NS EA 364
    rs1395138021,2
    --80910156(+) ACATAG/TGCATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SPRY2 (80910111 - 80915086 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPRY2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2747714CNV Deletion23290073
    nsv819288CNV Loss19587683
    nsv832660CNV Gain17160897


    Human Gene Mutation Database (HGMD): SPRY2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRY2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602466    OMIM disorders: --

    20/21 diseases for SPRY2 (see all 21):    About MalaCards
    cblc    thanatophoric dysplasia    achondroplasia    cleft lip
    cleft palate    endotheliitis    endometrial carcinoma    periodontitis
    neuroblastoma    b-cell lymphomas    pancreatic cancer    colon cancer
    prostatitis    hepatocellular carcinoma    lung cancer    sarcoma
    pancreatitis    glioblastoma    melanoma    prostate cancer


    SPRY2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SPRY2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 4 17510316 (2), 19147787 (1)

    Genetic Association Database (GAD): SPRY2
    Human Genome Epidemiology (HuGE) Navigator: SPRY2 (6 documents)

    Export disorders for SPRY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRY2 gene, integrated from 9 sources (see all 131):
    (articles sorted by number of sources associating them with SPRY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)1, 2, 3 Hacohen N.... Krasnow M.A. (1998)
    2. Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. (PubMed id 10887178)1, 2, 9 Lim J.... Guy G.R. (2000)
    3. Genetic variation near IRS1 associates with reduced a diposity and an impaired metabolic profile. (PubMed id 21706003)1, 4 KilpelAoinen T.O....Loos R.J. (2011)
    4. MTHFR and MSX1 contribute to the risk of nonsyndromic cleft lip/palate. (PubMed id 20572854)1, 4 JagomAogi T....Metspalu A. (2010)
    5. Genome-wide association study identifies two suscepti bility loci for nonsyndromic cleft lip with or without cleft palate. (PubMed id 20023658)1, 4 Mangold E....NAPthen M.M. (2010)
    6. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    7. Search for pathogenetic variants of the SPRY2 gene in intestinal innervation defects. (PubMed id 19545245)1, 4 Borghini S....Ceccherini I. (2009)
    8. Medical Sequencing of Candidate Genes for Nonsyndromic Cleft Lip and Palate. (PubMed id 16327884)1, 4 Vieira A.R.... Murray J.C. (2005)
    9. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10253 HGNC: 11270 AceView: SPRY2 Ensembl:ENSG00000136158 euGenes: HUgn10253
    ECgene: SPRY2 Kegg: 10253 H-InvDB: SPRY2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRY2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPRY2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPRY2 gene:
    Search GeneIP for patents involving SPRY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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