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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRY1 Gene

protein-coding   GIFtS: 59
GCID: GC04P124317

sprouty homolog 1, antagonist of FGF signaling (Drosophila)

(Previous name: sprouty (Drosophila) homolog 1 (antagonist of FGF signaling)...)
 Explore 11 diseases affiliated with
SPRY1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPRY1    

Aliases
for SPRY1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila)1 2     Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling)2
HSPRY11     Spry-13
Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling)1     Spry-13
Protein Sprouty Homolog 12     

External Ids:    HGNC: 112691   Entrez Gene: 102522   Ensembl: ENSG000001640567   OMIM: 6024655   UniProtKB: O436093   

Export aliases for SPRY1 gene to outside databases

Previous GC identifers: GC04P125233 GC04P124600 GC04P124713 GC04P124779 GC04P124776 GC04P124675 GC04P120044


Summaries
for SPRY1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609
Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
respiratory organogenesis

Gene Wiki entry for SPRY1


Genomic Views
for SPRY1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRY1 gene promoter:
         Oct-B1   AREB6   oct-B2   POU2F1   oct-B3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SPRY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q

SPRY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P124317:  view genomic region     (about GC identifiers)

Start:
 124,317,950 bp from pter      End:
 124,324,910 bp from pter
Size:
 6,961 bases      Orientation:
 plus strand

Proteins
for SPRY1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609 (See protein sequence)
Recommended Name: Protein sprouty homolog 1  
Size: 319 amino acids; 35122 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated
cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor)
Secondary accessions: D3DNX6 Q6PNE0

Explore the universe of human proteins at neXtProt for SPRY1: NX_O43609

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43609

    • SPRY1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001244967.1  NP_001244968.1  NP_005832.1  NP_955359.1  

    ENSEMBL proteins: 
     ENSP00000421622   ENSP00000343785   ENSP00000421036   ENSP00000377871   ENSP00000425946  
    Reactome Protein details: O43609
    Human Recombinant Protein Products: 
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    Novus Biologicals SPRY1 Proteins
    Novus Biologicals SPRY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPRY1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0030027lamellipodium NAS--


    SPRY1 for ontologies           About GeneDecksing



    SPRY1 Antibody Products: 
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    Uscn ELISAs and CLIAs for SPRY1

    Protein Domains /
    Families
    for SPRY1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPRY1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007875 Sprouty

    Graphical View of Domain Structure for InterPro Entry O43609

    ProtoNet protein and cluster: O43609

    1 Blocks protein family: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609
    Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
    Similarity: Belongs to the sprouty family
    Similarity: Contains 1 SPR (sprouty) domain


    Function
    for SPRY1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609
    Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
    respiratory organogenesis
    Induction: By FGF signaling

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SPRY1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY1 (see all 45):
    hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-29a hsa-miR-507 hsa-miR-550a* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: SPRY1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRY1 (see all 7)
    OriGene shRNA RFP: SPRY1
    OriGene siRNA: SPRY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRY1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPRY1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY1 (see all 5)
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SPRY1
    Search LifeMap BioReagents cell lines for SPRY1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--


    SPRY1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SPRY1:
     Decreased focal adhesion (FA)  

    Animal Models:
         Mouse knock-out Spry1tm1.1Jdli for SPRY1
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Spry1):
     endocrine/exocrine gland  mortality/aging  no phenotypic analysis  normal  renal/urinary system 
     reproductive system  tumorigenesis 

    SPRY1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SPRY1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Sprouty lures cytosolic CBL away from EGFR
    		Sprouty lures cytosolic CBL away from EGFR1.00
    		Sprouty lures membrane-bound CBL away from EGFR1.00
    2Signaling by FGFR
    		Signaling by EGFR0.84
    		Signaling by EGFR in Cancer0.83
    3MAP Kinase Signaling
    		MAP Kinase Signaling1.00
    4Disease
    		Disease1.00
    5Jak-STAT signaling pathway
    		Jak-STAT signaling pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SPRY1
        MAP Kinase Signaling

    5/7        Reactome Pathways for SPRY1 (see all 7)
        Sprouty lures cytosolic CBL away from EGFR
    Signal Transduction
    Signaling by EGFR in Cancer
    Signaling by EGFR
    Disease


    1         Kegg Pathway  (Kegg details for SPRY1):
        Jak-STAT signaling pathway


    SPRY1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for SPRY1 (O436091, 2, 3 ENSP000003437854) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932, 3, ENSP000003390074MINT-6169717 I2D: score=3 STRING: ENSP00000339007
    CBLP226812, 3, ENSP000002640334MINT-6169713 I2D: score=1 STRING: ENSP00000264033
    GEMIN4P576783, ENSP000003217064I2D: score=2 STRING: ENSP00000321706
    NEDD4P469343, ENSP000003455304I2D: score=1 STRING: ENSP00000345530
    TESK1Q155693, ENSP000003381274I2D: score=1 STRING: ENSP00000338127
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0001657ureteric bud development IEA--
    GO:0001759organ induction IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0008285negative regulation of cell proliferation IEA--


    SPRY1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPRY1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRY1
    Search CenterWatch for drugs/clinical trials and news about SPRY1 / SPY1 

    Transcripts
    for SPRY1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPRY1 gene (4 alternative transcripts): 
    NM_001258038.1  NM_001258039.1  NM_005841.2  NM_199327.2  

    Unigene Cluster for SPRY1:

    Sprouty homolog 1, antagonist of FGF signaling (Drosophila)
    Hs.436944  [show with all ESTs]
    Unigene Representative Sequence: NM_001258038
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505319 ENST00000339241(uc003ifa.3) ENST00000515726 ENST00000507703
    ENST00000394339(uc003ifb.3) ENST00000508849

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SPRY1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY1 (see all 45):
    hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-29a hsa-miR-507 hsa-miR-550a* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmid: SPRY1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRY1 (see all 7)
    OriGene shRNA RFP: SPRY1
    OriGene siRNA: SPRY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRY1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRY1 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SPRY1 (NM_005841)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRY1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY1

    Additional cDNA sequence: 

    AF041037.1 AK026960.1 AY192146.1 AY590694.1 BC063856.1 

    10 DOTS entries:

    DT.316390  DT.97841464  DT.99981553  DT.409490  DT.100664769  DT.100788758  DT.100788759  DT.100009994 
    DT.121264462  DT.92424612 

    24/171 AceView cDNA sequences (see all 171):

    BX281719 BQ882548 AI420101 AA627797 AI742465 AA055439 AL047498 CB241225 
    AA935405 NM_005841 AY590694 AI382440 AA505862 R73619 AA993018 AI588932 
    AI635042 BQ217397 AI039223 AI377693 BM972153 AI368389 AI421481 AW027076 

    GeneLoc Exon Structure


    Expression
    for SPRY1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTGAATATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPRY1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymePrechordal MesenchymeDiencephalic Neural Crest CellsNeural Crest
    Head MesenchymePrechordal MesenchymeMesencephalic Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    KidneyUreteric BudUreteric Bud Tip CellsKidney
    Neural EctodermNeural PlateIsthmus CellsNeural Ectoderm
    KidneyUreteric BudKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)

    See SPRY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRY1

    SOURCE GeneReport for Unigene cluster: Hs.436944
        SABiosciences Custom PCR Arrays for SPRY1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY1

    Orthologs
    for SPRY1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPRY1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPRY11 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 80.5(n)
    89.94(a)    		   395583  NM_001097524.1  NP_001090993.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SPRY16
    		 --
    		 86(a)
    		 1 ↔ 1
    		 5(138346599-138347561)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.100872 Xenopus laevis transcribed sequence with moderate similarity more 80.6(n)    BJ620864.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii spry11 sprouty homolog 1 (Drosophila) 60.53(n)
    65.04(a)    		   798229  NM_001122600.1  NP_001116072.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sty3 negative regulation of EGF receptor
    signaling more    		 46(a)   63D2   --


    ENSEMBL Gene Tree for SPRY1 (if available)
    TreeFam Gene Tree for SPRY1 (if available) 

    Paralogs
    for SPRY1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPRY1 gene
    SPRY32  SPRY22  SPRY42  
    3 SIMAP similar genes for SPRY1 using alignment to 5 protein entries:     SPY1_HUMAN (see all proteins):
    SPRY2    SPRY4    SPRY3

    SPRY1 for paralogs           About GeneDecksing



    Genomic Variants
    for SPRY1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SPRY1
         4 CNVs: 8454 3512 31186 2543
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRY1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRY1

    Disorders / Diseases
    for SPRY1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPRY1 for disorders           About GeneDecksing

    OMIM gene information: 602465    OMIM disorders: --

    11 diseases for SPRY1:    About MalaCards
    macular degeneration    chronic lymphocytic leukemia    lymphocytic leukemia    ovarian cancer
    prostate carcinoma    leukemia    prostatitis    prostate cancer
    ataxia    carcinoma    hepatocellular carcinoma

    Human Genome Epidemiology (HuGE) Navigator: SPRY1 (3 documents)

    Export disorders for SPRY1 gene to outside databases

    Publications
    for SPRY1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRY1 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with SPRY1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)1, 2, 3 Hacohen N.... Krasnow M.A. (1998)
    2. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PubMed id 15962011)1, 3 Haglund K.... Dikic I. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification and expression analysis of a novel splice variant of human Sprouty1 gene. (PubMed id 14533010)1, 2 Wang L.... Mao Y. (2003)
    5. Stromal expression of decorin, Semaphorin6D, SPARC, Sp routy1 and Tsukushi in developing prostate and decreased levels of decorin in pr ostate cancer. (PubMed id 22880013)1 Henke A....Thomson A.A. (2012)
    6. Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses. (PubMed id 23074222)1 Sharma B....Platanias L.C. (2012)
    7. Transcriptional and post-transcriptional regulation of Sprouty1, a receptor tyrosine kinase inhibitor in prostate cancer. (PubMed id 21826097)1 Darimipourain M....Kwabi-Addo B. (2011)
    8. Comparison of an expanded ataxia interactome with pat ient medical records reveals a relationship between macular degeneration and at axia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (2011)
    9. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
    10. Novel protein interactors of urokinase-type plasminog en activator receptor. (PubMed id 20696135)1 Mekkawy A.H....Pourgholami M.H. (2010)

    External Searches for SPRY1 gene

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    Genome Databases showing SPRY1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10252 HGNC: 11269 AceView: SPRY1 Ensembl:ENSG00000164056 euGenes: HUgn10252
    ECgene: SPRY1 Kegg: 10252 H-InvDB: SPRY1

    Other Databases showing SPRY1 gene

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    Specialized Databases showing SPRY1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for SPRY1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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