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Aliases for SPRY1 Gene

Aliases for SPRY1 Gene

  • Sprouty RTK Signaling Antagonist 1 2 3 5
  • Spry-1 3 4
  • Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling) 3
  • Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling 3
  • Protein Sprouty Homolog 1 3
  • HSPRY1 3

External Ids for SPRY1 Gene

Previous GeneCards Identifiers for SPRY1 Gene

  • GC04P125233
  • GC04P124600
  • GC04P124713
  • GC04P124779
  • GC04P124776
  • GC04P124675
  • GC04P124317
  • GC04P120044

Summaries for SPRY1 Gene

GeneCards Summary for SPRY1 Gene

SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include Adrenal Cortical Adenocarcinoma and Legius Syndrome. Among its related pathways are Signaling by GPCR and Angiogenesis (CST). An important paralog of this gene is SPRY2.

UniProtKB/Swiss-Prot for SPRY1 Gene

  • May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Gene Wiki entry for SPRY1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY1 Gene

Genomics for SPRY1 Gene

Regulatory Elements for SPRY1 Gene

Enhancers for SPRY1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G123442 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.9 +47.1 47109 2.2 PKNOX1 TCF12 GATA2 FOS ZNF263 SP5 SMARCA4 MYNN RCOR2 ETV4 SPRY1 ENSG00000249125
GH04G123477 1.6 FANTOM5 Ensembl ENCODE 12.1 +82.2 82215 4.0 HNRNPUL1 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 TCF12 SPRY1 ENSG00000249125 LINC02435
GH04G123552 1.5 Ensembl ENCODE dbSUPER 12.3 +158.5 158507 5.6 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 ZNF48 YY1 GLIS2 GATA2 SPRY1 ENSG00000249125 LOC105377405 LINC01091
GH04G123415 1.5 Ensembl ENCODE dbSUPER 12.2 +22.1 22146 7.8 PKNOX1 FOXA2 ATF1 MLX ARID4B SIN3A FEZF1 DMAP1 ETS1 TCF12 SPRY1 ENSG00000249125
GH04G123564 1.5 Ensembl ENCODE dbSUPER 12.2 +168.2 168239 0.9 PKNOX1 MLX ARNT ARID4B TCF12 ZNF766 CBX5 GATA2 ZNF143 REST SPRY1 LOC105377405 LINC01091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPRY1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPRY1 Gene

Chromosome:
4
Start:
123,396,791 bp from pter
End:
123,403,760 bp from pter
Size:
6,970 bases
Orientation:
Plus strand

Genomic View for SPRY1 Gene

Genes around SPRY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY1 Gene

Proteins for SPRY1 Gene

  • Protein details for SPRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43609-SPY1_HUMAN
    Recommended name:
    Protein sprouty homolog 1
    Protein Accession:
    O43609
    Secondary Accessions:
    • D3DNX6
    • Q6PNE0

    Protein attributes for SPRY1 Gene

    Size:
    319 amino acids
    Molecular mass:
    35122 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRY1 Gene

Post-translational modifications for SPRY1 Gene

  • Ubiquitination at posLast=167167
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPRY1 Gene

Domains & Families for SPRY1 Gene

Protein Domains for SPRY1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPRY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43609

UniProtKB/Swiss-Prot:

SPY1_HUMAN :
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
  • Belongs to the sprouty family.
Domain:
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles.
Family:
  • Belongs to the sprouty family.
genes like me logo Genes that share domains with SPRY1: view

No data available for Gene Families for SPRY1 Gene

Function for SPRY1 Gene

Molecular function for SPRY1 Gene

UniProtKB/Swiss-Prot Function:
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
UniProtKB/Swiss-Prot Induction:
By FGF signaling.

Gene Ontology (GO) - Molecular Function for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with SPRY1: view
genes like me logo Genes that share phenotypes with SPRY1: view

Animal Models for SPRY1 Gene

MGI Knock Outs for SPRY1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPRY1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRY1 Gene

Localization for SPRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRY1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
golgi apparatus 4
extracellular 2
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with SPRY1: view

Pathways & Interactions for SPRY1 Gene

genes like me logo Genes that share pathways with SPRY1: view

Pathways by source for SPRY1 Gene

3 Cell Signaling Technology pathways for SPRY1 Gene
3 Reactome pathways for SPRY1 Gene

SIGNOR curated interactions for SPRY1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IEA --
GO:0001759 organ induction IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with SPRY1: view

Drugs & Compounds for SPRY1 Gene

No Compound Related Data Available

Transcripts for SPRY1 Gene

Unigene Clusters for SPRY1 Gene

Sprouty homolog 1, antagonist of FGF signaling (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SPRY1

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY1 Gene

No ASD Table

Relevant External Links for SPRY1 Gene

GeneLoc Exon Structure for
SPRY1
ECgene alternative splicing isoforms for
SPRY1

Expression for SPRY1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPRY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRY1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.7) and Adipose - Visceral (Omentum) (x4.6).

Protein differential expression in normal tissues from HIPED for SPRY1 Gene

This gene is overexpressed in Breast (61.4) and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRY1 Gene



Protein tissue co-expression partners for SPRY1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRY1 Gene:

SPRY1

SOURCE GeneReport for Unigene cluster for SPRY1 Gene:

Hs.744854

Evidence on tissue expression from TISSUES for SPRY1 Gene

  • Nervous system(4.4)
  • Heart(2.5)
  • Lung(2.4)
  • Muscle(2.4)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with SPRY1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRY1 Gene

Orthologs for SPRY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRY1 34 35
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia SPRY1 34 35
  • 94.15 (n)
cow
(Bos Taurus)
Mammalia SPRY1 34 35
  • 93.42 (n)
mouse
(Mus musculus)
Mammalia Spry1 34 16 35
  • 82.96 (n)
oppossum
(Monodelphis domestica)
Mammalia SPRY1 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPRY1 34
  • 80.29 (n)
lizard
(Anolis carolinensis)
Reptilia SPRY1 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spry1 34
  • 75.39 (n)
Str.10330 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10087 34
zebrafish
(Danio rerio)
Actinopterygii spry1 34 35
  • 59.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta sty 36 35
  • 46 (a)
Species where no ortholog for SPRY1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRY1 Gene

ENSEMBL:
Gene Tree for SPRY1 (if available)
TreeFam:
Gene Tree for SPRY1 (if available)

Paralogs for SPRY1 Gene

Paralogs for SPRY1 Gene

(3) SIMAP similar genes for SPRY1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPRY1: view

Variants for SPRY1 Gene

Sequence variations from dbSNP and Humsavar for SPRY1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000475492 -- 123,399,887(+) GCTTG(A/C)AAATG intron-variant
rs1000789776 -- 123,398,904(+) AGTGT(A/G)CCTCA intron-variant, upstream-variant-2KB
rs1001285453 -- 123,399,506(+) TCCGT(C/T)AACTA intron-variant, utr-variant-5-prime
rs1002110121 -- 123,403,377(+) TGTGT(C/T)ACAGA utr-variant-3-prime
rs1002197646 -- 123,397,351(+) ACGCG(C/T)AGAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRY1 Gene

Variant ID Type Subtype PubMed ID
esv2759280 CNV gain 17122850
esv34581 CNV gain 17911159
esv3602044 CNV gain 21293372
nsv10562 CNV gain+loss 18304495

Variation tolerance for SPRY1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRY1 Gene

Human Gene Mutation Database (HGMD)
SPRY1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRY1 Gene

Disorders for SPRY1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPRY1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenocarcinoma
  • adrenocortical carcinoma
legius syndrome
  • neurofibromatosis type 1-like syndrome
- elite association - COSMIC cancer census association via MalaCards
Search SPRY1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPRY1

Genetic Association Database (GAD)
SPRY1
Human Genome Epidemiology (HuGE) Navigator
SPRY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRY1
genes like me logo Genes that share disorders with SPRY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRY1 Gene

Publications for SPRY1 Gene

  1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N. … Krasnow M.A. (Cell 1998) 2 3 4 64
  2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
  3. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PMID: 15962011) Haglund K. … Dikic I. (EMBO Rep. 2005) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification and expression analysis of a novel splice variant of human Sprouty1 gene. (PMID: 14533010) Wang L. … Mao Y. (Int. J. Mol. Med. 2003) 3 4 64

Products for SPRY1 Gene

  • Addgene plasmids for SPRY1

Sources for SPRY1 Gene

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