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SPRY1 Gene

protein-coding   GIFtS: 58
GCID: GC04P124317

Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila)

(Previous name: sprouty (Drosophila) homolog 1 (antagonist of FGF signaling))
  See SPRY1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila)1 2     Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling)2
Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling)1     spry-12
hSPRY12     Spry-13
Protein Sprouty Homolog 12     

External Ids:    HGNC: 112691   Entrez Gene: 102522   Ensembl: ENSG000001640567   OMIM: 6024655   UniProtKB: O436093   

Export aliases for SPRY1 gene to outside databases

Previous GC identifers: GC04P125233 GC04P124600 GC04P124713 GC04P124779 GC04P124776 GC04P124675 GC04P120044


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPRY1 Gene:
SPRY1 (sprouty homolog 1, antagonist of FGF signaling (Drosophila)) is a protein-coding gene. Diseases associated with SPRY1 include legius syndrome. An important paralog of this gene is SPRY3.

UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609
Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
respiratory organogenesis

Gene Wiki entry for SPRY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SPRY1 gene promoter:
         Oct-B1   AREB6   oct-B2   POU2F1   oct-B3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SPRY1 promoter sequence
   Search Chromatin IP Primers for SPRY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q

SPRY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P124317:  view genomic region     (about GC identifiers)

Start:
124,317,950 bp from pter      End:
124,324,910 bp from pter
Size:
6,961 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609 (See protein sequence)
Recommended Name: Protein sprouty homolog 1  
Size: 319 amino acids; 35122 Da
Secondary accessions: D3DNX6 Q6PNE0

Explore the universe of human proteins at neXtProt for SPRY1: NX_O43609

Explore proteomics data for SPRY1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys167
  • Modification sites at PhosphoSitePlus

  • See SPRY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001244967.1  NP_001244968.1  NP_005832.1  NP_955359.1  

    ENSEMBL proteins: 
     ENSP00000421622   ENSP00000343785   ENSP00000421036   ENSP00000377871   ENSP00000425946  
    Reactome Protein details: O43609

    SPRY1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SPRY1
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    Novus Biologicals SPRY1 Proteins
    Novus Biologicals SPRY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPRY1

     
    Search eBioscience for Proteins for SPRY1 

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    Search eBioscience for ELISAs for SPRY1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007875 Sprouty

    Graphical View of Domain Structure for InterPro Entry O43609

    ProtoNet protein and cluster: O43609

    1 Blocks protein domain: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609
    Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
    Similarity: Belongs to the sprouty family
    Similarity: Contains 1 SPR (sprouty) domain


    Find genes that share domains with SPRY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPY1_HUMAN, O43609
    Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
    respiratory organogenesis
    Induction: By FGF signaling

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with SPRY1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPRY1:
     Decreased focal adhesion (FA)  

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Spry1):
     endocrine/exocrine gland  mortality/aging  no phenotypic analysis  normal  renal/urinary system 
     reproductive system  tumorigenesis 

    Find genes that share phenotypes with SPRY1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Spry1tm1.1Jdli for SPRY1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRY1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPRY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRY1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRY1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPRY1:
    hsa-mir-98-5p (MIRT027552), hsa-mir-3615 (MIRT052850), hsa-mir-26b-5p (MIRT029134), hsa-mir-324-3p (MIRT042959)

    Block miRNA regulation of human, mouse, rat SPRY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRY1 (see all 45):
    hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-29a hsa-miR-507 hsa-miR-550a* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPRY1
    Predesigned siRNA for gene silencing in human, mouse, rat SPRY1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPRY1

    Clone
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    OriGene clones in human, mouse for SPRY1 (see all 14)
    OriGene ORF clones in mouse, rat for SPRY1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPRY1 (NM_005841)
    Sino Biological Human cDNA Clone for SPRY1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SPRY1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY1

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-14289) for SPRY1 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPY1_HUMAN, O43609: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in
    unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth
    factor)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus2
    cytoskeleton1
    endosome1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0030027lamellipodium ----

    Find genes that share ontologies with SPRY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPRY1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.83
    Signaling by EGFR in Cancer0.82
    2Signaling by GPCR
    Signal Transduction0.58
    3Prostate Cancer
    Prostate Cancer0.32
    4MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31
    5Jak-STAT signaling pathway
    Jak-STAT signaling pathway


    Find genes that share SuperPaths with SPRY1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SPRY1
        MAP Kinase Signaling

    1 BioSystems Pathway for SPRY1
        Prostate Cancer


    1 Reactome Pathway for SPRY1
        EGFR downregulation


    1 Kegg Pathway  (Kegg details for SPRY1):
        Jak-STAT signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRY1
    Interactions:

        Search GeneGlobe Interaction Network for SPRY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SPRY1 (O436091, 2, 3 ENSP000003437854) via UniProtKB, MINT, STRING, and/or I2D (see all 92)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932, 3, ENSP000003390074MINT-6169717 I2D: score=3 STRING: ENSP00000339007
    CBLP226812, 3, ENSP000002640334MINT-6169713 I2D: score=1 STRING: ENSP00000264033
    GEMIN4P576783, ENSP000003217064I2D: score=2 STRING: ENSP00000321706
    NEDD4P469343, ENSP000003455304I2D: score=1 STRING: ENSP00000345530
    TESK1Q155693, ENSP000003381274I2D: score=1 STRING: ENSP00000338127
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0001657ureteric bud development IEA--
    GO:0001759organ induction IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007275multicellular organismal development ----

    Find genes that share ontologies with SPRY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRY1 (SPY1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPRY1 gene (4 alternative transcripts): 
    NM_001258038.1  NM_001258039.1  NM_005841.2  NM_199327.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505319 ENST00000339241(uc003ifa.3) ENST00000515726 ENST00000507703
    ENST00000394339(uc003ifb.3) ENST00000508849
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPRY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRY1 (see all 45):
    hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-29a hsa-miR-507 hsa-miR-550a* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPRY1
    Predesigned siRNA for gene silencing in human, mouse, rat SPRY1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPRY1 (NM_005841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPRY1
    OriGene qSTAR qPCR primer pairs in human, mouse for SPRY1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPRY1
      QuantiTect SYBR Green Assays in human, mouse, rat SPRY1
      QuantiFast Probe-based Assays in human, mouse, rat SPRY1
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-14289) for SPRY1 

    Selected AceView cDNA sequences (see all 171):

    AA935405 AI277093 BM972153 BU151445 CB241225 AI742465 AI039223 BC063856 
    AI400015 AI805683 AA339799 BX386455 AI382440 AA627797 BQ217397 CA950581 
    BQ882548 AI635042 AI350357 BX281719 AY590694 BQ613949 AA055439 AA993018 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPRY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAATATA
    SPRY1 Expression
    About this image


    SPRY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Lens Placode Cells Lens Placode
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Isthmus Cells Neural Plate
             Floor plate-like cells
    SPRY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRY1 Protein Expression
        Custom PCR Arrays for SPRY1
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    Products:
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    QuantiFast Probe-based Assays in human, mouse, rat SPRY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPRY1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spry11 , 5 sprouty homolog 1 (Drosophila)1, 5 82.96(n)1
    85.21(a)1
      3 (18.46 cM)5
    240631  NM_011896.21  NP_036026.11 
     376399475 
    chicken
    (Gallus gallus)
    Aves SPRY11 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 80.29(n)
    89.94(a)
      395583  NM_001097524.1  NP_001090993.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPRY16
    sprouty homolog 1, antagonist of FGF signaling (Dr...
    86(a)
    1 ↔ 1
    5(138346599-138347561)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100872 Xenopus laevis transcribed sequence with moderate similarity more 80.6(n)    BJ620864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spry11 sprouty homolog 1 (Drosophila) 59.18(n)
    63.3(a)
      798229  NM_001122600.1  NP_001116072.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sty3 negative regulation of EGF receptor
    signaling more
    46(a)   63D2   --


    ENSEMBL Gene Tree for SPRY1 (if available)
    TreeFam Gene Tree for SPRY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPRY1 gene
    SPRY32  SPRY42  SPRY22  
    3 SIMAP similar genes for SPRY1 using alignment to 5 protein entries:     SPY1_HUMAN (see all proteins):
    SPRY2    SPRY4    SPRY3

    Find genes that share paralogs with SPRY1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPRY1 (see all 206)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472649141,2
    --124315972(+) CAATGC/TATACT 2 -- us2k10--------
    rs3005661,2
    C,F,A,H--124316038(+) AGGCAG/AGTTTC 2 -- us2k112Minor allele frequency- A:0.20NS NA WA CSA EA 492
    rs48332771,2
    C,F,A--124316052(+) CAATGT/CCTTTT 2 -- us2k110Minor allele frequency- C:0.41NA WA EA 372
    rs1871843621,2
    --124316082(+) TATACA/GTACAT 2 -- us2k10--------
    rs1913151391,2
    --124316169(+) ACTCTC/GTACAG 2 -- us2k10--------
    rs1408328731,2
    --124316265(+) ATACTC/TGATCT 2 -- us2k10--------
    rs1838406011,2
    --124316522(+) TCCATC/TACTAG 2 -- us2k10--------
    rs3005671,2
    C,F,H--124316684(-) CATCAC/TTAGAA 2 -- us2k113Minor allele frequency- T:0.01NS NA WA CSA EA 696
    rs1903136731,2
    --124316902(+) ACTTAC/TATGTT 2 -- us2k10--------
    rs1168937451,2
    F--124316917(+) TGATTT/CAGATT 2 -- us2k11Minor allele frequency- C:0.01EA 120

    HapMap Linkage Disequilibrium report for SPRY1 (124317950 - 124324910 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPRY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34581CNV Gain17911159
    nsv10562CNV Gain+Loss18304495
    dgv1669e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRY1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602465    OMIM disorders: --

    1 disease for SPRY1:    
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    legius syndrome


    Find genes that share disorders with SPRY1           About GenesLikeMe

    Genetic Association Database (GAD): SPRY1
    Human Genome Epidemiology (HuGE) Navigator: SPRY1 (3 documents)

    Export disorders for SPRY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPRY1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with SPRY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)1, 2, 3 Hacohen N.... Krasnow M.A. (Cell 1998)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    3. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PubMed id 15962011)1, 3 Haglund K.... Dikic I. (EMBO Rep. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Identification and expression analysis of a novel splice variant of human Sprouty1 gene. (PubMed id 14533010)1, 2 Wang L.... Mao Y. (Int. J. Mol. Med. 2003)
    6. miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1. (PubMed id 23441172)1 BrA...Sheikh S.P. (PLoS ONE 2013)
    7. Spry1 and Spry4 differentially regulate human aortic smooth muscle cell phenotype via Akt/FoxO/myocardin signaling. (PubMed id 23554919)1 Yang X....Friesel R.E. (PLoS ONE 2013)
    8. Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women. (PubMed id 23146288)1 Jin H.S....Jeong S.Y. (Mol. Genet. Metab. 2013)
    9. BCL11B is up-regulated by EWS/FLI and contributes to the transformed phenotype in Ewing sarcoma. (PubMed id 23527175)1 Wiles E.T....Lessnick S.L. (PLoS ONE 2013)
    10. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10252 HGNC: 11269 AceView: SPRY1 Ensembl:ENSG00000164056 euGenes: HUgn10252
    ECgene: SPRY1 Kegg: 10252 H-InvDB: SPRY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPRY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPRY1 gene:
    Search GeneIP for patents involving SPRY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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