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Aliases for SPRY1 Gene

Aliases for SPRY1 Gene

  • Sprouty RTK Signaling Antagonist 1 2 3
  • Spry-1 3 4
  • Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling) 3
  • Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila) 2
  • Sprouty Homolog 1, Antagonist Of FGF Signaling 3
  • HSPRY1 3

External Ids for SPRY1 Gene

Previous GeneCards Identifiers for SPRY1 Gene

  • GC04P125233
  • GC04P124600
  • GC04P124713
  • GC04P124779
  • GC04P124776
  • GC04P124675
  • GC04P124317
  • GC04P120044

Summaries for SPRY1 Gene

GeneCards Summary for SPRY1 Gene

SPRY1 (Sprouty RTK Signaling Antagonist 1) is a Protein Coding gene. Diseases associated with SPRY1 include adrenal cortical adenocarcinoma and legius syndrome. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. An important paralog of this gene is SPRY3.

UniProtKB/Swiss-Prot for SPRY1 Gene

  • May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis

Gene Wiki entry for SPRY1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY1 Gene

Genomics for SPRY1 Gene

Regulatory Elements for SPRY1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPRY1 Gene

Chromosome:
4
Start:
123,396,791 bp from pter
End:
123,403,760 bp from pter
Size:
6,970 bases
Orientation:
Plus strand

Genomic View for SPRY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY1 Gene

Proteins for SPRY1 Gene

  • Protein details for SPRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43609-SPY1_HUMAN
    Recommended name:
    Protein sprouty homolog 1
    Protein Accession:
    O43609
    Secondary Accessions:
    • D3DNX6
    • Q6PNE0

    Protein attributes for SPRY1 Gene

    Size:
    319 amino acids
    Molecular mass:
    35122 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRY1 Gene

Proteomics data for SPRY1 Gene at MOPED

Post-translational modifications for SPRY1 Gene

  • Ubiquitination at Lys 167
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SPRY1 (SPRY1)
  • Cloud-Clone Corp. Antibodies for SPRY1

No data available for DME Specific Peptides for SPRY1 Gene

Domains & Families for SPRY1 Gene

Protein Domains for SPRY1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPRY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43609

UniProtKB/Swiss-Prot:

SPY1_HUMAN :
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
  • Belongs to the sprouty family.
Domain:
  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
  • Contains 1 SPR (sprouty) domain.
Family:
  • Belongs to the sprouty family.
genes like me logo Genes that share domains with SPRY1: view

No data available for Gene Families for SPRY1 Gene

Function for SPRY1 Gene

Molecular function for SPRY1 Gene

UniProtKB/Swiss-Prot Function:
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis
UniProtKB/Swiss-Prot Induction:
By FGF signaling

Gene Ontology (GO) - Molecular Function for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23088713
genes like me logo Genes that share ontologies with SPRY1: view
genes like me logo Genes that share phenotypes with SPRY1: view

Animal Models for SPRY1 Gene

MGI Knock Outs for SPRY1:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRY1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPRY1 Gene

Localization for SPRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRY1 Gene COMPARTMENTS Subcellular localization image for SPRY1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
cytoskeleton 1
endosome 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SPRY1: view

Pathways & Interactions for SPRY1 Gene

genes like me logo Genes that share pathways with SPRY1: view

Pathways by source for SPRY1 Gene

3 Cell Signaling Technology pathways for SPRY1 Gene
1 BioSystems pathway for SPRY1 Gene
3 Reactome pathways for SPRY1 Gene

SIGNOR curated interactions for SPRY1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IEA --
GO:0001759 organ induction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SPRY1: view

Drugs & Compounds for SPRY1 Gene

No Compound Related Data Available

Transcripts for SPRY1 Gene

Unigene Clusters for SPRY1 Gene

Sprouty homolog 1, antagonist of FGF signaling (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRY1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY1 Gene

No ASD Table

Relevant External Links for SPRY1 Gene

GeneLoc Exon Structure for
SPRY1
ECgene alternative splicing isoforms for
SPRY1

Expression for SPRY1 Gene

mRNA expression in normal human tissues for SPRY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRY1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x4.7) and Adipose - Visceral (Omentum) (x4.6).

Protein differential expression in normal tissues from HIPED for SPRY1 Gene

This gene is overexpressed in Breast (61.4) and Heart (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRY1 Gene



SOURCE GeneReport for Unigene cluster for SPRY1 Gene Hs.744854

genes like me logo Genes that share expression patterns with SPRY1: view

Protein tissue co-expression partners for SPRY1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPRY1 Gene

Orthologs for SPRY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPRY1 35
  • 93.42 (n)
  • 96.24 (a)
SPRY1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPRY1 35
  • 94.15 (n)
  • 97.81 (a)
SPRY1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spry1 35
  • 82.96 (n)
  • 85.21 (a)
Spry1 16
Spry1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPRY1 35
  • 99.69 (n)
  • 99.69 (a)
SPRY1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPRY1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPRY1 35
  • 80.29 (n)
  • 89.94 (a)
lizard
(Anolis carolinensis)
Reptilia SPRY1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spry1 35
  • 75.39 (n)
  • 78.23 (a)
Str.10330 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10087 35
zebrafish
(Danio rerio)
Actinopterygii spry1 35
  • 59.18 (n)
  • 63.3 (a)
spry1 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sty 37
  • 46 (a)
sty 36
  • 16 (a)
OneToMany
Species with no ortholog for SPRY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRY1 Gene

ENSEMBL:
Gene Tree for SPRY1 (if available)
TreeFam:
Gene Tree for SPRY1 (if available)

Paralogs for SPRY1 Gene

Paralogs for SPRY1 Gene

(3) SIMAP similar genes for SPRY1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPRY1: view

Variants for SPRY1 Gene

Structural Variations from Database of Genomic Variants (DGV) for SPRY1 Gene

Variant ID Type Subtype PubMed ID
dgv1669e1 CNV Complex 17122850
nsv10562 CNV Gain+Loss 18304495
esv34581 CNV Gain 17911159

Variation tolerance for SPRY1 Gene

Residual Variation Intolerance Score: 19.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 20.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRY1 Gene

HapMap Linkage Disequilibrium report
SPRY1
Human Gene Mutation Database (HGMD)
SPRY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for SPRY1 Gene

Disorders for SPRY1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPRY1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adrenal cortical adenocarcinoma
  • adrenal cortex adenocarcinoma
legius syndrome
  • neurofibromatosis type 1-like syndrome
- elite association
Search SPRY1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPRY1

Genetic Association Database (GAD)
SPRY1
Human Genome Epidemiology (HuGE) Navigator
SPRY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRY1
genes like me logo Genes that share disorders with SPRY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRY1 Gene

Publications for SPRY1 Gene

  1. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PMID: 15962011) Haglund K. … Dikic I. (EMBO Rep. 2005) 2 67
  2. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N. … Krasnow M.A. (Cell 1998) 2 67
  3. Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation. (PMID: 24604720) Terada N. … Getzenberg R.H. (J. Cell. Biochem. 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Sprouty1 induces a senescence-associated secretory phenotype by regulating NFI_B activity: implications for tumorigenesis. (PMID: 24270409) MaciA A. … Encinas M. (Cell Death Differ. 2014) 67

Products for SPRY1 Gene

Sources for SPRY1 Gene

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