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Aliases for SPRY1 Gene

Aliases for SPRY1 Gene

  • Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila) 2 3
  • Spry-1 3 4
  • Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling) 3
  • Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling) 2
  • Protein Sprouty Homolog 1 3
  • HSPRY1 3

External Ids for SPRY1 Gene

Summaries for SPRY1 Gene

GeneCards Summary for SPRY1 Gene

SPRY1 (Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila)) is a Protein Coding gene. Diseases associated with SPRY1 include legius syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. An important paralog of this gene is SPRY3.

UniProtKB/Swiss-Prot for SPRY1 Gene

  • May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis

Gene Wiki entry for SPRY1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRY1 Gene

Genomics for SPRY1 Gene

Genomic Location for SPRY1 Gene

123,396,791 bp from pter
123,403,760 bp from pter
6,970 bases
Plus strand

Genomic View for SPRY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRY1 Gene

Regulatory Elements for SPRY1 Gene

Proteins for SPRY1 Gene

  • Protein details for SPRY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein sprouty homolog 1
    Protein Accession:
    Secondary Accessions:
    • D3DNX6
    • Q6PNE0

    Protein attributes for SPRY1 Gene

    319 amino acids
    Molecular mass:
    35122 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRY1 Gene

Proteomics data for SPRY1 Gene at MOPED

Post-translational modifications for SPRY1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys167

Other Protein References for SPRY1 Gene

No data available for DME Specific Peptides for SPRY1 Gene

Domains for SPRY1 Gene

Protein Domains for SPRY1 Gene



  • The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles:
    • O43609
  • Contains 1 SPR (sprouty) domain.:
    • O43609
  • Belongs to the sprouty family.:
    • O43609
genes like me logo Genes that share domains with SPRY1: view

No data available for Gene Families for SPRY1 Gene

Function for SPRY1 Gene

Molecular function for SPRY1 Gene

UniProtKB/Swiss-Prot Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis
UniProtKB/Swiss-Prot Induction: By FGF signaling

Gene Ontology (GO) - Molecular Function for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23088713
genes like me logo Genes that share ontologies with SPRY1: view
genes like me logo Genes that share phenotypes with SPRY1: view

Animal Models for SPRY1 Gene

MGI Knock Outs for SPRY1:

miRNA for SPRY1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPRY1 Gene

Localization for SPRY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRY1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Subcellular locations from

Jensen Localization Image for SPRY1 Gene COMPARTMENTS Subcellular localization image for SPRY1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
nucleus 2
cytoskeleton 1
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SPRY1: view

Pathways for SPRY1 Gene

genes like me logo Genes that share pathways with SPRY1: view

Pathways by source for SPRY1 Gene

1 Cell Signaling Technology pathway for SPRY1 Gene
1 BioSystems pathway for SPRY1 Gene

Gene Ontology (GO) - Biological Process for SPRY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0001656 metanephros development IEA --
GO:0001657 ureteric bud development IEA --
GO:0001759 organ induction IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with SPRY1: view

Transcripts for SPRY1 Gene

Unigene Clusters for SPRY1 Gene

Sprouty homolog 1, antagonist of FGF signaling (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRY1 Gene

No ASD Table

Relevant External Links for SPRY1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRY1 Gene

mRNA expression in normal human tissues for SPRY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRY1 Gene

This gene is overexpressed in Adipose - Subcutaneous (4.7) and Adipose - Visceral (Omentum) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRY1 Gene

SOURCE GeneReport for Unigene cluster for SPRY1 Gene Hs.744854

genes like me logo Genes that share expressions with SPRY1: view

Orthologs for SPRY1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRY1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRY1 36
  • 99.69 (n)
  • 99.69 (a)
SPRY1 37
  • 100 (a)
(Bos Taurus)
Mammalia SPRY1 36
  • 93.42 (n)
  • 96.24 (a)
SPRY1 37
  • 96 (a)
(Canis familiaris)
Mammalia SPRY1 36
  • 94.15 (n)
  • 97.81 (a)
SPRY1 37
  • 94 (a)
(Mus musculus)
Mammalia Spry1 36
  • 82.96 (n)
  • 85.21 (a)
Spry1 16
Spry1 37
  • 85 (a)
(Monodelphis domestica)
Mammalia SPRY1 37
  • 67 (a)
(Gallus gallus)
Aves SPRY1 36
  • 80.29 (n)
  • 89.94 (a)
(Anolis carolinensis)
Reptilia SPRY1 37
  • 86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10087 36
tropical clawed frog
(Silurana tropicalis)
Amphibia spry1 36
  • 75.39 (n)
  • 78.23 (a)
Str.10330 36
(Danio rerio)
Actinopterygii spry1 36
  • 59.18 (n)
  • 63.3 (a)
spry1 37
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta sty 37
  • 16 (a)
sty 38
  • 46 (a)
Species with no ortholog for SPRY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRY1 Gene

Gene Tree for SPRY1 (if available)
Gene Tree for SPRY1 (if available)

Paralogs for SPRY1 Gene

Paralogs for SPRY1 Gene

Selected SIMAP similar genes for SPRY1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPRY1: view

Variants for SPRY1 Gene

Sequence variations from dbSNP and Humsavar for SPRY1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs159762 -- 123,401,439(+) TAGGC(A/G)GTTTA intron-variant
rs186190 -- 123,401,282(+) TTCTG(C/T)TTCTT intron-variant
rs190974 -- 123,401,346(+) TTCCT(A/C)TATGA intron-variant
rs300566 -- 123,394,883(+) AGGCA(A/G)GTTTC upstream-variant-2KB
rs300567 -- 123,395,529(-) CATCA(C/T)TAGAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRY1 Gene

Variant ID Type Subtype PubMed ID
dgv1669e1 CNV Complex 17122850
nsv10562 CNV Gain+Loss 18304495
esv34581 CNV Gain 17911159

Relevant External Links for SPRY1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for SPRY1 Gene

(1) MalaCards Diseases for SPRY1 Gene

Search for SPRY1 Gene in MalaCards »

Relevant External Links for SPRY1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPRY1: view

No data available for UniProtKB/Swiss-Prot for SPRY1 Gene

Publications for SPRY1 Gene

  1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PMID: 9458049) Hacohen N. … Krasnow M.A. (Cell 1998) 2 3 4
  2. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PMID: 15962011) Haglund K. … Dikic I. (EMBO Rep. 2005) 2 3
  3. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 49
  4. Identification and expression analysis of a novel splice variant of human Sprouty1 gene. (PMID: 14533010) Wang L. … Mao Y. (Int. J. Mol. Med. 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SPRY1 Gene

  • antibodies-online proteins for SPRY1
  • antibodies-online antibodies for SPRY1
  • antibodies-online kits for SPRY1

Sources for SPRY1 Gene

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