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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRY1 Gene

protein-coding   GIFtS: 60
GCID: GC04P124317

Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila)

(Previous name: sprouty (Drosophila) homolog 1 (antagonist of FGF signaling))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sprouty Homolog 1, Antagonist Of FGF Signaling (Drosophila)1 2     Sprouty, Drosophila, Homolog Of, 1 (Antagonist Of FGF Signaling)2
Sprouty (Drosophila) Homolog 1 (Antagonist Of FGF Signaling)1     spry-12
hSPRY12     Spry-13
Protein Sprouty Homolog 12     

External Ids:    HGNC: 112691   Entrez Gene: 102522   Ensembl: ENSG000001640567   OMIM: 6024655   UniProtKB: O436093   

Export aliases for SPRY1 gene to outside databases

Previous GC identifers: GC04P125233 GC04P124600 GC04P124713 GC04P124779 GC04P124776 GC04P124675 GC04P120044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPRY1 Gene: 
SPRY1 (sprouty homolog 1, antagonist of FGF signaling (Drosophila)) is a protein-coding gene. Diseases associated with SPRY1 include chronic lymphocytic leukemia, and macular degeneration, and among its related super-pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include protein binding. An important paralog of this gene is SPRY3.

UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609
Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
respiratory organogenesis

Gene Wiki entry for SPRY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRY1 gene promoter:
         Oct-B1   AREB6   oct-B2   POU2F1   oct-B3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SPRY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.1   Ensembl cytogenetic band:  4q28.1   HGNC cytogenetic band: 4q

SPRY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRY1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P124317:  view genomic region     (about GC identifiers)

Start:
124,317,950 bp from pter      End:
124,324,910 bp from pter
Size:
6,961 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609 (See protein sequence)
Recommended Name: Protein sprouty homolog 1  
Size: 319 amino acids; 35122 Da
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in
unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth
factor)
Secondary accessions: D3DNX6 Q6PNE0

Explore the universe of human proteins at neXtProt for SPRY1: NX_O43609

Explore proteomics data for SPRY1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43609

  • SPRY1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPRY1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001244967.1  NP_001244968.1  NP_005832.1  NP_955359.1  

    ENSEMBL proteins: 
     ENSP00000421622   ENSP00000343785   ENSP00000421036   ENSP00000377871   ENSP00000425946  
    Reactome Protein details: O43609
    Human Recombinant Protein Products for SPRY1: 
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    GenScript Custom Purified and Recombinant Proteins Services for SPRY1
    Novus Biologicals SPRY1 Proteins
    Novus Biologicals SPRY1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPRY1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0030027lamellipodium NAS--

    SPRY1 for ontologies           About GeneDecksing



    SPRY1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for SPRY1 

    Assay Products for SPRY1: 
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    Cloud-Clone Corp. CLIAs for SPRY1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007875 Sprouty

    Graphical View of Domain Structure for InterPro Entry O43609

    ProtoNet protein and cluster: O43609

    1 Blocks protein domain: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPY1_HUMAN, O43609
    Domain: The Cys-rich domain is responsible for the localization of the protein to the membrane ruffles
    Similarity: Belongs to the sprouty family
    Similarity: Contains 1 SPR (sprouty) domain


    SPRY1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPY1_HUMAN, O43609
    Function: May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate
    respiratory organogenesis
    Induction: By FGF signaling

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    SPRY1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPRY1:
     Decreased focal adhesion (FA)  

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Spry1):
     endocrine/exocrine gland  mortality/aging  no phenotypic analysis  normal  renal/urinary system 
     reproductive system  tumorigenesis 

    SPRY1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Spry1tm1.1Jdli for SPRY1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRY1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPRY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRY1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRY1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRY1
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY1 (see all 45):
    hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-29a hsa-miR-507 hsa-miR-550a* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPRY1
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SPRY1 (NM_005841)
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                         Customized lentivirus expression plasmids for stable overexpression of SPRY1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPRY1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by FGFR
    Signaling by EGFR0.84
    Signaling by EGFR in Cancer0.83
    2Signaling by GPCR
    Signal Transduction0.55
    3Prostate Cancer
    Prostate Cancer0.32
    4Endocytic Trafficking of EGFR
    EGFR downregulation0.30
    5MAP Kinase Signaling
    MAP Kinase Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for SPRY1
        MAP Kinase Signaling

    1 BioSystems Pathway for SPRY1
        Prostate Cancer


    5        Reactome Pathways for SPRY1
        Signal Transduction
    Signaling by EGFR in Cancer
    Signaling by EGFR
    Disease
    EGFR downregulation


    1         Kegg Pathway  (Kegg details for SPRY1):
        Jak-STAT signaling pathway


    SPRY1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/32 Interacting proteins for SPRY1 (O436091, 2, 3 ENSP000003437854) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629932, 3, ENSP000003390074MINT-6169717 I2D: score=3 STRING: ENSP00000339007
    CBLP226812, 3, ENSP000002640334MINT-6169713 I2D: score=1 STRING: ENSP00000264033
    GEMIN4P576783, ENSP000003217064I2D: score=2 STRING: ENSP00000321706
    NEDD4P469343, ENSP000003455304I2D: score=1 STRING: ENSP00000345530
    TESK1Q155693, ENSP000003381274I2D: score=1 STRING: ENSP00000338127
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001656metanephros development IEA--
    GO:0001657ureteric bud development IEA--
    GO:0001759organ induction IEA--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007275multicellular organismal development ----

    SPRY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRY1 (SPY1)

    Search CenterWatch for drugs/clinical trials and news about SPRY1 / SPY1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRY1 gene (4 alternative transcripts): 
    NM_001258038.1  NM_001258039.1  NM_005841.2  NM_199327.2  

    Unigene Cluster for SPRY1:

    Sprouty homolog 1, antagonist of FGF signaling (Drosophila)
    Hs.744854  [show with all ESTs]
    Unigene Representative Sequence: NM_001258038
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505319 ENST00000339241(uc003ifa.3) ENST00000515726 ENST00000507703
    ENST00000394339(uc003ifb.3) ENST00000508849
    miRNA
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRY1 (see all 45):
    hsa-miR-300 hsa-miR-4272 hsa-miR-1224-3p hsa-miR-29a hsa-miR-507 hsa-miR-550a* hsa-miR-570 hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidSPRY1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRY1
    Clone
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    OriGene clones in human, mouse for SPRY1 (see all 15)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPRY1 (NM_005841)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRY1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRY1
    Sirion Biotech Customized lentivirus for stable overexpression of SPRY1 
                         Customized lentivirus expression plasmids for stable overexpression of SPRY1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPRY1
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPRY1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRY1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY1

    Additional mRNA sequence: 

    AF041037.1 AK026960.1 AY192146.1 AY590694.1 BC063856.1 

    10 DOTS entries:

    DT.316390  DT.97841464  DT.99981553  DT.409490  DT.100664769  DT.100788758  DT.100788759  DT.100009994 
    DT.121264462  DT.92424612 

    24/171 AceView cDNA sequences (see all 171):

    NM_005841 AA055439 AA505862 AI632034 CD521667 R73619 AI742465 AI093966 
    AI018640 CA448471 CB241225 AI264451 AI588932 BQ718566 AW027076 AA993018 
    AI277093 AI377693 BX281719 AA339799 AI866894 AI039223 BC063856 AI635042 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRY1 expression in normal human tissues (normalized intensities)      SPRY1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGAATATA
    SPRY1 Expression
    About this image


    SPRY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Thalamus
             Septum   
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 3 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Mesencephalic Neural Crest Cells Prechordal Mesenchyme
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Human Cardiac Myocytes-adult (HCM-a)   
     
     Neural Ectoderm (Nervous System)
             Isthmus Cells Neural Plate

    See SPRY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRY1

    SOURCE GeneReport for Unigene cluster: Hs.744854
        SABiosciences Custom PCR Arrays for SPRY1
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPRY1 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spry11 , 5 sprouty homolog 1 (Drosophila)1, 5 82.85(n)1
    84.98(a)1
      3 (18.46 cM)5
    240631  NM_011896.21  NP_036026.11 
     376399475 
    chicken
    (Gallus gallus)
    Aves SPRY11 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 80.5(n)
    89.94(a)
      395583  NM_001097524.1  NP_001090993.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPRY16
    Uncharacterized protein
    86(a)
    1 ↔ 1
    5(138346599-138347561)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.100872 Xenopus laevis transcribed sequence with moderate similarity more 80.6(n)    BJ620864.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spry11 sprouty homolog 1 (Drosophila) 60.53(n)
    65.04(a)
      798229  NM_001122600.1  NP_001116072.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sty3 negative regulation of EGF receptor
    signaling more
    46(a)   63D2   --


    ENSEMBL Gene Tree for SPRY1 (if available)
    TreeFam Gene Tree for SPRY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPRY1 gene
    SPRY32  SPRY42  SPRY22  
    3 SIMAP similar genes for SPRY1 using alignment to 5 protein entries:     SPY1_HUMAN (see all proteins):
    SPRY2    SPRY4    SPRY3

    SPRY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/206 SNPs in SPRY1 are shown (see all 206)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472649141,2
    --124315972(+) CAATGC/TATACT 2 -- us2k10--------
    rs3005661,2
    C,F,A,H--124316038(+) AGGCAG/AGTTTC 2 -- us2k112Minor allele frequency- A:0.20NS NA WA CSA EA 492
    rs48332771,2
    C,F,A--124316052(+) CAATGT/CCTTTT 2 -- us2k110Minor allele frequency- C:0.41NA WA EA 372
    rs1871843621,2
    --124316082(+) TATACA/GTACAT 2 -- us2k10--------
    rs1913151391,2
    --124316169(+) ACTCTC/GTACAG 2 -- us2k10--------
    rs1408328731,2
    --124316265(+) ATACTC/TGATCT 2 -- us2k10--------
    rs1838406011,2
    --124316522(+) TCCATC/TACTAG 2 -- us2k10--------
    rs3005671,2
    C,F,H--124316684(-) CATCAC/TTAGAA 2 -- us2k113Minor allele frequency- T:0.01NS NA WA CSA EA 696
    rs1903136731,2
    --124316902(+) ACTTAC/TATGTT 2 -- us2k10--------
    rs1168937451,2
    F--124316917(+) TGATTT/CAGATT 2 -- us2k11Minor allele frequency- C:0.01EA 120

    HapMap Linkage Disequilibrium report for SPRY1 (124317950 - 124324910 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPRY1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34581CNV Gain17911159
    nsv10562CNV Gain+Loss18304495
    dgv1669e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602465    OMIM disorders: --

    8 diseases for SPRY1:    About MalaCards
    chronic lymphocytic leukemia    macular degeneration    ataxia    prostatitis
    hepatocellular carcinoma    ovarian cancer    prostate cancer    leukemia


    SPRY1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPRY1
    Human Genome Epidemiology (HuGE) Navigator: SPRY1 (3 documents)

    Export disorders for SPRY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRY1 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with SPRY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (PubMed id 9458049)1, 2, 3 Hacohen N.... Krasnow M.A. (1998)
    2. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    3. Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation. (PubMed id 15962011)1, 3 Haglund K.... Dikic I. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification and expression analysis of a novel splice variant of human Sprouty1 gene. (PubMed id 14533010)1, 2 Wang L.... Mao Y. (2003)
    6. miR-21 promotes fibrogenic epithelial-to-mesenchymal t ransition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1. (PubMed id 23441172)1 Bronnum H....Sheikh S.P. (2013)
    7. Association between the SPRY1 gene polymorphism and ob esity-related traits and osteoporosis in Korean women. (PubMed id 23146288)1 Jin H.S....Jeong S.Y. (2013)
    8. BCL11B is up-regulated by EWS/FLI and contributes to t he transformed phenotype in Ewing sarcoma. (PubMed id 23527175)1 Wiles E.T....Lessnick S.L. (2013)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. Feedback regulations of miR-21 and MAPKs via Pdcd4 and Spry1 are involved in arsenite-induced cell malignant transformation. (PubMed id 23469214)1 Shen L....Liu Q. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10252 HGNC: 11269 AceView: SPRY1 Ensembl:ENSG00000164056 euGenes: HUgn10252
    ECgene: SPRY1 Kegg: 10252 H-InvDB: SPRY1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPRY1 gene:
    Search GeneIP for patents involving SPRY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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