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SPRTN Gene

protein-coding   GIFtS: 40
GCID: GC01P231473

SprT-Like N-Terminal Domain

(Previous name: chromosome 1 open reading frame 124)
(Previous symbol: C1orf124)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
SprT-Like N-Terminal Domain1 2     DNA Damage Protein Targeting VCP2 3
C1orf1241 2 3     Chromosome 1 Open Reading Frame 1241
DNA Damage-Targeting VCP (P97) Adaptor1 2     DDDL18802
SprT-Like Domain At The N Terminus1 2     PRO43232
Protein With SprT-Like Domain At The N Terminus2 3     dJ876B10.32
DVC12 3     SprT-Like Domain-Containing Protein Spartan2
Spartan2 3     Zinc Finger RAD18 Domain-Containing Protein C1orf1242

External Ids:    HGNC: 253561   Entrez Gene: 839322   Ensembl: ENSG000000100727   UniProtKB: Q9H0403   

Export aliases for SPRTN gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPRTN Gene:
SPRTN (SprT-like N-terminal domain) is a protein-coding gene. GO annotations related to this gene include ubiquitin binding and K63-linked polyubiquitin binding.

UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040
Function: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances
RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and
interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates
chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward
loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting
VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent
excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage

Gene Wiki entry for SPRTN (C1orf124) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for SPRTN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SPRTN promoter sequence
   Search Chromatin IP Primers for SPRTN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12-q43   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.12-q43

SPRTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRTN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P231473:  view genomic region     (about GC identifiers)

Start:
231,472,850 bp from pter      End:
231,490,769 bp from pter
Size:
17,920 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040 (See protein sequence)
Recommended Name: SprT-like domain-containing protein Spartan  
Size: 489 amino acids; 55134 Da
Subunit: Interacts with PCNA (when ubiquitinated). Interacts with RAD18. Interacts (via its SHP-box) with VCP/p97.
Interacts with KCTD13 and POLD3
Developmental stage: Predominantly expressed during S- and G2-phases and early M-phase. It then drops, and is
probably degraded by the APC/C complex
Sequence caution: Sequence=BAB55037.1; Type=Frameshift; Positions=224;
Secondary accessions: B1AKT0 B5MEF7 Q5TE78 Q6UWW6 Q96BC5 Q96KA0
Alternative splicing: 3 isoforms:  Q9H040-1   Q9H040-2   Q9H040-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPRTN: NX_Q9H040

Explore proteomics data for SPRTN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys84, Lys98, Lys203, Lys271, Lys280, Lys341, Lys361, Lys407, Lys414, Lys423,
                                 Lys424, Lys435
  • Modification sites at PhosphoSitePlus

  • See SPRTN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001010984.1  NP_001248391.1  NP_114407.3  

    ENSEMBL proteins: 
     ENSP00000375731   ENSP00000295050   ENSP00000008440   ENSP00000355604  

    SPRTN Human Recombinant Protein Products:

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    Novus Biologicals SPRTN Protein
    Novus Biologicals SPRTN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SPRTN 

     
    antibodies-online proteins for SPRTN (2 products) 

     
    antibodies-online peptides for SPRTN

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    LSBio Antibodies in human, mouse, rat for SPRTN
    antibodies-online antibodies for SPRTN (17 products) 

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SPRTN 
    antibodies-online kits for SPRTN (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR006642 Znf_Rad18_put
     IPR006640 SprT-like_domain

    Graphical View of Domain Structure for InterPro Entry Q9H040

    ProtoNet protein and cluster: Q9H040

    UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040
    Domain: The PIP-box mediates the interaction with PCNA, while the UBZ-type zinc finger mediates binding to
    'Lys-48'- and 'Lys-63'-linked polyubiquitin (PubMed:22894931, PubMed:22681887, PubMed:23042607, PubMed:23042605
    and PubMed:22987070)
    Similarity: Belongs to the Spartan family
    Similarity: Contains 1 SprT-like domain
    Similarity: Contains 1 UBZ-type zinc finger


    Find genes that share domains with SPRTN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRTN_HUMAN, Q9H040
    Function: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances
    RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and
    interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates
    chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward
    loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting
    VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent
    excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0043130ubiquitin binding IDA--
    GO:0046872metal ion binding IEA--
    GO:0070530K63-linked polyubiquitin binding IDA--
         
    Find genes that share ontologies with SPRTN           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRTN
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    miRNA
    Products:
        
    miRTarBase miRNAs that target SPRTN:
    hsa-mir-186-5p (MIRT021124), hsa-mir-125a-5p (MIRT045716), hsa-mir-125b-5p (MIRT045975), hsa-mir-548b-3p (MIRT016242)

    Block miRNA regulation of human, mouse, rat SPRTN using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SPRTN
    SwitchGear 3'UTR luciferase reporter plasmidSPRTN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPRTN

    Gene Editing
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    GenScript Custom all cDNA clones Services for SPRTN
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRTN

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPRTN_HUMAN, Q9H040: Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to
    stalled relication forks at sites of replication stress

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0016607nuclear speck IDA--

    Find genes that share ontologies with SPRTN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRTN
    Interactions:

        Search GeneGlobe Interaction Network for SPRTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SPRTN (Q9H0403 ENSP000002950504) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF11Q9Y3C53I2D: score=1 
    PCNAENSP000003684384STRING: ENSP00000368438
    RAD18ENSP000002649264STRING: ENSP00000264926
    UBBENSP000003046974STRING: ENSP00000304697
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair ----
    GO:0006974cellular response to DNA damage stimulus IDA--
    GO:0009411response to UV IDA--
    GO:0019985translesion synthesis IMP--
    GO:0031398positive regulation of protein ubiquitination IDA--

    Find genes that share ontologies with SPRTN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRTN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPRTN gene (3 alternative transcripts): 
    NM_001010984.2  NM_001261462.1  NM_032018.5  

    Unigene Cluster for SPRTN:

    SprT-like N-terminal domain
    Hs.554892  [show with all ESTs]
    Unigene Representative Sequence: NM_001010984
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391858(uc001hus.3 uc001hut.3) ENST00000295050(uc001hur.3)
    ENST00000008440 ENST00000492437 ENST00000366644 ENST00000469904
    miRNA
    Products:
         
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    SwitchGear 3'UTR luciferase reporter plasmidSPRTN 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRTN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPRTN
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      QuantiTect SYBR Green Assays in human, mouse, rat SPRTN
      QuantiFast Probe-based Assays in human, mouse, rat SPRTN

    Additional mRNA sequence: 

    AK027317.1 AK027613.1 AL512744.1 AY358611.1 BC015740.1 BC068478.1 

    8 DOTS entries:

    DT.409917  DT.312857  DT.99946301  DT.121385085  DT.101968840  DT.101956350  DT.109305  DT.121385094 

    Selected AceView cDNA sequences (see all 108):

    AA829880 F04699 AI860772 BM825143 CA307905 AA952985 F02793 BM127014 
    F01559 AI425019 BC015740 AY358611 AI250178 CB142597 AL601965 CA432649 
    AA825746 BM971303 CA438464 AL512744 BE301472 BI761715 Z39470 AI952663 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPRTN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                -               
    SP2:                          -     -               
    SP3:                                                


    ECgene alternative splicing isoforms for SPRTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPRTN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPRTN Expression
    About this image


    SPRTN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    SPRTN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRTN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.554892
        Custom PCR Arrays for SPRTN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPRTN gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sprtn1 , 5 predicted gene 5055
    SprT-like N-terminal domain1
    74.5(n)1
    72.35(a)1
      8 (72.83 cM)5
    2446661  NM_001111141.11  NP_001104611.11 
     1248978865 
    chicken
    (Gallus gallus)
    Aves C3H1ORF1241 chromosome 3 open reading frame, human C1orf124 59.24(n)
    52.65(a)
      421530  XM_419571.4  XP_419571.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPRTN6
    SprT-like N-terminal domain
    51(a)
    1 ↔ 1
    1(221751682-221761280)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX843701.12   -- 76.54(n)    BX843701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1018861621 sprT-like domain-containing protein Spartan-like 60.62(n)
    59.82(a)
      101886162  XM_005173806.1  XP_005173863.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92036
    --
    22(a)
    1 ↔ 1
    X(15366837-15369433)
    worm
    (Caenorhabditis elegans)
    Secernentea dvc-16
    Protein DVC-1 (dvc-1) mRNA, complete cds
    44(a)
    1 ↔ 1
    V(11237438-11239323) WBGene00011834


    ENSEMBL Gene Tree for SPRTN (if available)
    TreeFam Gene Tree for SPRTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPRTN (see all 364)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs574632981,2
    C--201970293(+) AAAAA-/A/AA  
            
    GACTG
    3 -- int11NA 2
    rs2016835661,2
    --231475601(+) AAGAAA/GGGATC 6 K R mis10--------
    rs2020967491,2
    --231475602(+) AGAAAA/GGATCT 6 K syn10--------
    rs10610651,2
    H--231475617(+) GAGGTA/TTTTTT 3 -- int16Minor allele frequency- T:0.01MN NS EA NA 598
    rs30719541,2
    C--231475793(-) TTTTT-/T/TT  
            
    ACTAT
    3 -- int1 trp31NA 2
    rs120817611,2
    A--231475808(+) AAAAAC/AAAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1404143011,2
    --231475859(+) ATCCCA/GACACT 3 -- int10--------
    rs66754481,2
    C--231475936(+) accccA/Gtctct 3 -- int10--------
    rs2037521,2
    C,H--231476036(-) tcctcG/Agttca 3 -- int18Minor allele frequency- A:0.00NA CSA 16
    rs1118006221,2
    C,F--231476055(+) TTGCAG/ATGAGC 3 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SPRTN (231472850 - 231490769 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPRTN: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRTN
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPRTN gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with SPRTN)
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    1. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. (PubMed id 22681887)1, 2, 3 Centore R.C.... Zou L. (Mol. Cell 2012)
    2. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. (PubMed id 22902628)1, 2 Ghosal G.... Chen J. (J. Biol. Chem. 2012)
    3. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. (PubMed id 23042605)1, 2 Mosbech A.... Mailand N. (Nat. Struct. Mol. Biol. 2012)
    4. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. (PubMed id 23042607)1, 2 Davis E.J....Rouse J. (Nat. Struct. Mol. Biol. 2012)
    5. Spartan/C1orf124 is important to prevent UV-induced mutagenesis. (PubMed id 22894931)1, 2 Machida Y.... Machida Y.J. (Cell Cycle 2012)
    6. Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance. (PubMed id 22987070)1, 2 Juhasz S.... Haracska L. (Nucleic Acids Res. 2012)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Regulation of error-prone translesion synthesis by Spartan/C1orf124. (PubMed id 23254330)1 Kim M.S....Machida Y.J. (Nucleic Acids Res. 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83932 HGNC: 25356 AceView: DKFZP547N043 Ensembl:ENSG00000010072 euGenes: HUgn83932
    ECgene: SPRTN H-InvDB: SPRTN

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPRTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for SPRTN gene:
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    GeneCards and IP:
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