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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRTN Gene

protein-coding   GIFtS: 39
GCID: GC01P231473

SprT-Like N-Terminal Domain

(Previous name: chromosome 1 open reading frame 124)
(Previous symbol: C1orf124)
  Search for SPRTN
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SprT-Like N-Terminal Domain1 2     DNA Damage Protein Targeting VCP2 3
C1orf1241 2 3     Chromosome 1 Open Reading Frame 1241
DNA Damage-Targeting VCP (P97) Adaptor1 2     DDDL18802
SprT-Like Domain At The N Terminus1 2     PRO43232
Protein With SprT-Like Domain At The N Terminus2 3     dJ876B10.32
DVC12 3     SprT-Like Domain-Containing Protein Spartan2
Spartan2 3     Zinc Finger RAD18 Domain-Containing Protein C1orf1242

External Ids:    HGNC: 253561   Entrez Gene: 839322   Ensembl: ENSG000000100727   UniProtKB: Q9H0403   

Export aliases for SPRTN gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPRTN Gene: 
SPRTN (SprT-like N-terminal domain) is a protein-coding gene. GO annotations related to this gene include ubiquitin binding and K63-linked polyubiquitin binding.

UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040
Function: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances
RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and
interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates
chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward
loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting
VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent
excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage

Gene Wiki entry for SPRTN (C1orf124) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SPRTN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SPRTN promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12-q43   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.12-q43

SPRTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRTN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P231473:  view genomic region     (about GC identifiers)

Start:
231,472,850 bp from pter      End:
231,490,769 bp from pter
Size:
17,920 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040 (See protein sequence)
Recommended Name: SprT-like domain-containing protein Spartan  
Size: 489 amino acids; 55134 Da
Subunit: Interacts with PCNA (when ubiquitinated). Interacts with RAD18. Interacts (via its SHP-box) with VCP/p97.
Interacts with KCTD13 and POLD3
Subcellular location: Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to
stalled relication forks at sites of replication stress
Developmental stage: Predominantly expressed during S- and G2-phases and early M-phase. It then drops, and is
probably degraded by the APC/C complex
Sequence caution: Sequence=BAB55037.1; Type=Frameshift; Positions=224;
Secondary accessions: B1AKT0 B5MEF7 Q5TE78 Q6UWW6 Q96BC5 Q96KA0
Alternative splicing: 3 isoforms:  Q9H040-1   Q9H040-2   Q9H040-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPRTN: NX_Q9H040

Explore proteomics data for SPRTN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H040

  • SPRTN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPRTN Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001010984.1  NP_001248391.1  NP_114407.3  

    ENSEMBL proteins: 
     ENSP00000375731   ENSP00000295050   ENSP00000008440   ENSP00000355604  

    Human Recombinant Protein Products for SPRTN: 
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    Novus Biologicals SPRTN Protein
    Novus Biologicals SPRTN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0016607nuclear speck IDA--

    SPRTN for ontologies           About GeneDecksing



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    Abcam antibodies for SPRTN
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    LSBio Antibodies in human, mouse, rat for SPRTN 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006642 Znf_Rad18_put
     IPR006640 SprT-like_domain

    Graphical View of Domain Structure for InterPro Entry Q9H040

    ProtoNet protein and cluster: Q9H040

    UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040
    Domain: The PIP-box mediates the interaction with PCNA, while the UBZ-type zinc finger mediates binding to
    'Lys-48'- and 'Lys-63'-linked polyubiquitin (PubMed:22894931, PubMed:22681887, PubMed:23042607, PubMed:23042605
    and PubMed:22987070)
    Similarity: Belongs to the Spartan family
    Similarity: Contains 1 SprT-like domain
    Similarity: Contains 1 UBZ-type zinc finger


    SPRTN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRTN_HUMAN, Q9H040
    Function: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances
    RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and
    interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates
    chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward
    loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting
    VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent
    excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0043130ubiquitin binding IDA--
    GO:0046872metal ion binding IEA--
    GO:0070530K63-linked polyubiquitin binding IDA--
         
    SPRTN for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRTN 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRTN 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidSPRTN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRTN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for SPRTN (Q9H0403 ENSP000002950504) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF11Q9Y3C53I2D: score=1 
    PCNAENSP000003684384STRING: ENSP00000368438
    RAD18ENSP000002649264STRING: ENSP00000264926
    UBBENSP000003046974STRING: ENSP00000304697
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair ----
    GO:0006974response to DNA damage stimulus IDA--
    GO:0009411response to UV IDA--
    GO:0019985translesion synthesis IMP--
    GO:0031398positive regulation of protein ubiquitination IDA--

    SPRTN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRTN

    Search CenterWatch for drugs/clinical trials and news about SPRTN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRTN gene (3 alternative transcripts): 
    NM_001010984.2  NM_001261462.1  NM_032018.5  

    Unigene Cluster for SPRTN:

    SprT-like N-terminal domain
    Hs.554892  [show with all ESTs]
    Unigene Representative Sequence: NM_001010984
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391858(uc001hus.3 uc001hut.3) ENST00000295050(uc001hur.3)
    ENST00000008440 ENST00000492437 ENST00000366644 ENST00000469904
    miRNA
    Products:
         
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    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPRTN
    SwitchGear 3'UTR luciferase reporter plasmidSPRTN 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRTN
    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of SPRTN 
    Primer
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    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat SPRTN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRTN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRTN

    Additional mRNA sequence: 

    AK027317.1 AK027613.1 AL512744.1 AY358611.1 BC015740.1 BC068478.1 

    8 DOTS entries:

    DT.409917  DT.312857  DT.99946301  DT.121385085  DT.101968840  DT.101956350  DT.109305  DT.121385094 

    24/108 AceView cDNA sequences (see all 108):

    AA757970 AL512744 CB142597 AA825746 BI761536 BE301472 F02793 BM127014 
    AI425019 BM825143 AA829880 Z39470 AL601965 AA952985 BI761715 AI860772 
    AI952663 CA307905 CA438464 AI250178 F04699 CA432649 F01559 BM971303 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPRTN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                -               
    SP2:                          -     -               
    SP3:                                                


    ECgene alternative splicing isoforms for SPRTN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See SPRTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRTN

    SOURCE GeneReport for Unigene cluster: Hs.554892
        SABiosciences Custom PCR Arrays for SPRTN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRTN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPRTN gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sprtn1 , 5 predicted gene 5055
    SprT-like N-terminal domain1
    74.43(n)1
    72.56(a)1
      8 (72.83 cM)5
    2446661  NM_001111141.11  NP_001104611.11 
     1248978865 
    chicken
    (Gallus gallus)
    Aves SPRTN1 SprT-like N-terminal domain 58.58(n)
    52.32(a)
      421530  XM_419571.3  XP_419571.2 
    lizard
    (Anolis carolinensis)
    Reptilia SPRTN6
    Uncharacterized protein
    48(a)
    1 ↔ 1
    1(221751682-221761280)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX843701.12   -- 76.54(n)    BX843701.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fam89a1 family with sequence similarity 89, member A 60.62(n)
    59.52(a)
      568145  XM_002665651.2  XP_002665697.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG92036
    --
    21(a)
    1 ↔ 1
    X(15366837-15369433)
    worm
    (Caenorhabditis elegans)
    Secernentea dvc-16
    SprT-like domain-containing protein Spartan
    44(a)
    1 ↔ 1
    V(11237438-11239323)


    ENSEMBL Gene Tree for SPRTN (if available)
    TreeFam Gene Tree for SPRTN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/364 SNPs in SPRTN are shown (see all 364)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs574632981,2
    C--201970293(+) AAAAA-/A/AA  
            
    GACTG
    3 -- int11NA 2
    rs2016835661,2
    --231475601(+) AAGAAA/GGGATC 6 K R mis10--------
    rs2020967491,2
    --231475602(+) AGAAAA/GGATCT 6 K syn10--------
    rs10610651,2
    H--231475617(+) GAGGTA/TTTTTT 3 -- int16Minor allele frequency- T:0.01MN NS EA NA 598
    rs30719541,2
    C--231475793(-) TTTTT-/T/TT  
            
    ACTAT
    3 -- int1 trp31NA 2
    rs120817611,2
    A--231475808(+) AAAAAC/AAAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1404143011,2
    --231475859(+) ATCCCA/GACACT 3 -- int10--------
    rs66754481,2
    C--231475936(+) accccA/Gtctct 3 -- int10--------
    rs2037521,2
    C,H--231476036(-) tcctcG/Agttca 3 -- int18Minor allele frequency- A:0.00NA CSA 16
    rs1118006221,2
    C,F--231476055(+) TTGCAG/ATGAGC 3 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for SPRTN (231472850 - 231490769 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPRTN: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRTN
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRTN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRTN gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with SPRTN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. (PubMed id 22681887)1, 2, 3 Centore R.C....Zou L. (2012)
    2. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. (PubMed id 22902628)1, 2 Ghosal G.... Chen J. (2012)
    3. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. (PubMed id 23042605)1, 2 Mosbech A.... Mailand N. (2012)
    4. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. (PubMed id 23042607)1, 2 Davis E.J....Rouse J. (2012)
    5. Spartan/C1orf124 is important to prevent UV-induced mutagenesis. (PubMed id 22894931)1, 2 Machida Y.... Machida Y.J. (2012)
    6. Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance. (PubMed id 22987070)1, 2 Juhasz S.... Haracska L. (2012)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Regulation of error-prone translesion synthesis by Spa rtan/C1orf124. (PubMed id 23254330)1 Kim M.S....Machida Y.J. (2013)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83932 HGNC: 25356 AceView: DKFZP547N043 Ensembl:ENSG00000010072 euGenes: HUgn83932
    ECgene: SPRTN H-InvDB: SPRTN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRTN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPRTN gene:
    Search GeneIP for patents involving SPRTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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