Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRTN Gene

protein-coding   GIFtS: 40
GCID: GC01P231473

SprT-like N-terminal domain

(Previous name: chromosome 1 open reading frame 124 )
(Previous symbol: C1orf124)
 Explore 1 disease affiliated with
SPRTN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPRTN    

Aliases
for SPRTN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SprT-Like N-Terminal Domain1 2     DDDL18802
C1orf1241 2 3     PRO43232
DVC11 2 3     DJ876B10.31
Spartan1 2 3     DNA Damage-Targeting VCP (P97) Adaptor2
Protein With SprT-Like Domain At The N Terminus2 3     SprT-Like Domain At The N Terminus2
DNA Damage Protein Targeting VCP2 3     SprT-Like Domain-Containing Protein Spartan2
DKFZP547N0431     Zinc Finger RAD18 Domain-Containing Protein C1orf1242
Chromosome 1 Open Reading Frame 1241     

External Ids:    HGNC: 253561   Entrez Gene: 839322   Ensembl: ENSG000000100727   UniProtKB: Q9H0403   

Export aliases for SPRTN gene to outside databases


Summaries
for SPRTN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040
Function: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances
RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts
with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin
association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance
PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA
damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA
synthesis and limit the incidence of mutations induced by DNA damage

Gene Wiki entry for SPRTN (C1orf124)


Genomic Views
for SPRTN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for SPRTN
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SPRTN promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRTN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRTN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.12-q43   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.12-q43

SPRTN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRTN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P231473:  view genomic region     (about GC identifiers)

Start:
 231,472,850 bp from pter      End:
 231,490,769 bp from pter
Size:
 17,920 bases      Orientation:
 plus strand

Proteins
for SPRTN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040 (See protein sequence)
Recommended Name: SprT-like domain-containing protein Spartan  
Size: 489 amino acids; 55134 Da
Subunit: Interacts with PCNA (when ubiquitinated). Interacts with RAD18. Interacts (via its SHP-box) with VCP/p97.
Interacts with KCTD13 and POLD3
Subcellular location: Nucleus. Chromosome. Note=Localizes to sites of UV damage via the PIP-box. Recruited to stalled
relication forks at sites of replication stress
Developmental stage: Predominantly expressed during S- and G2-phases and early M-phase. It then drops, and is probably
degraded by the APC/C complex
Secondary accessions: B5MEF7 Q5TE78 Q6UWW6 Q96BC5
Alternative splicing: 2 isoforms:  Q9H040-1   Q9H040-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPRTN: NX_Q9H040

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H040

    • SPRTN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001010984.1  NP_001248391.1  NP_114407.3  

    ENSEMBL proteins: 
     ENSP00000375731   ENSP00000295050   ENSP00000008440   ENSP00000355604  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: SPRTN
    OriGene Custom Protein Services for SPRTN 
    GenScript Custom Purified and Recombinant Proteins Services for SPRTN
    Novus Biologicals SPRTN Protein
    Novus Biologicals SPRTN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPRTN

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome IEA--
    GO:0016607nuclear speck IDA--


    SPRTN for ontologies           About GeneDecksing



    SPRTN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPRTN 
    GenScript Custom Superior Antibodies Services for SPRTN
    Novus Biologicals SPRTN Antibody
    Search for Antibodies for SPRTN at Abcam  
    Uscn Antibodies for SPRTN
    Search ThermoFisher Antibodies for SPRTN

    Assay Products for SPRTN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPRTN
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SPRTN

    Protein Domains /
    Families
    for SPRTN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPRTN for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR006640 SprT-like_domain
     IPR006642 Znf_Rad18_put

    Graphical View of Domain Structure for InterPro Entry Q9H040

    ProtoNet protein and cluster: Q9H040

    UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040
    Domain: The PIP-box mediates the interaction with PCNA, while the UBZ-type zinc finger mediates binding to 'Lys-48'-
    and 'Lys-63'-linked polyubiquitin (PubMed:22894931, PubMed:22681887, PubMed:23042607, PubMed:23042605 and
    PubMed:22987070)
    Similarity: Belongs to the Spartan family
    Similarity: Contains 1 SprT-like domain
    Similarity: Contains 1 UBZ-type zinc finger


    Function
    for SPRTN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPRTN_HUMAN, Q9H040
    Function: Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances
    RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts
    with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin
    association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance
    PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA
    damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA
    synthesis and limit the incidence of mutations induced by DNA damage

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SPRTN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRTN
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPRTN
    SwitchGear 3'UTR luciferase reporter plasmid: SPRTN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRTN (see all 6)
    OriGene shRNA RFP: SPRTN
    OriGene siRNA: SPRTN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRTN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPRTN

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRTN (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRTN (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for SPRTN
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRTN 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SPRTN
    Search LifeMap BioReagents cell lines for SPRTN

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRTN

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0043130ubiquitin binding IDA--
    GO:0046872metal ion binding IEA--
    GO:0070530K63-linked polyubiquitin binding IDA--


    SPRTN for ontologies           About GeneDecksing



    Pathways & Interactions
    for SPRTN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRTN

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for SPRTN (Q9H0403 ENSP000002950504) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF11Q9Y3C53I2D: score=1 
    PCNAENSP000003684384STRING: ENSP00000368438
    RAD18ENSP000002649264STRING: ENSP00000264926
    UBBENSP000003046974STRING: ENSP00000304697
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair ----
    GO:0006974response to DNA damage stimulus IDA--
    GO:0009411response to UV IDA--
    GO:0019985translesion synthesis IMP--
    GO:0031398positive regulation of protein ubiquitination IDA--


    SPRTN for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPRTN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRTN
    Search CenterWatch for drugs/clinical trials and news about SPRTN 

    Transcripts
    for SPRTN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPRTN gene (3 alternative transcripts): 
    NM_001010984.2  NM_001261462.1  NM_032018.5  

    Unigene Cluster for SPRTN:

    SprT-like N-terminal domain
    Hs.554892  [show with all ESTs]
    Unigene Representative Sequence: NM_001010984
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000391858(uc001hus.3 uc001hut.3) ENST00000295050(uc001hur.3)
    ENST00000008440 ENST00000492437 ENST00000366644 ENST00000469904

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SPRTN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRTN
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPRTN
    SwitchGear 3'UTR luciferase reporter plasmid: SPRTN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRTN (see all 6)
    OriGene shRNA RFP: SPRTN
    OriGene siRNA: SPRTN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRTN
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRTN (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRTN (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for SPRTN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRTN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRTN 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRTN
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat SPRTN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRTN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRTN

    Additional cDNA sequence: 

    AK027317.1 AK027613.1 AL512744.1 AY358611.1 BC015740.1 BC068478.1 

    8 DOTS entries:

    DT.409917  DT.312857  DT.99946301  DT.121385085  DT.101968840  DT.101956350  DT.109305  DT.121385094 

    24/108 AceView cDNA sequences (see all 108):

    CA307905 BM825143 AI860772 AA825746 AI425019 BI761715 AL512744 BI761536 
    AY358611 BM971303 F01559 AI250178 AI952663 Z39470 AL601965 BC015740 
    BM127014 CA432649 F04699 AA829880 AA757970 CB142597 AA952985 F02793 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPRTN    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b
    SP1:                                -               
    SP2:                          -     -               
    SP3:                                                


    ECgene alternative splicing isoforms for SPRTN

    Expression
    for SPRTN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    		 See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    SPRTN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesSecondary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPRTN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRTN

    SOURCE GeneReport for Unigene cluster: Hs.554892
        SABiosciences Custom PCR Arrays for SPRTN
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRTN
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat SPRTN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRTN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRTN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRTN

    Orthologs
    for SPRTN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPRTN gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sprtn1 , 5 predicted gene 5055
    SprT-like N-terminal domain1    		 74.43(n)1
    72.56(a)1    		   8 (72.83 cM)5
    2446661  NM_001111141.11  NP_001104611.11 
     1248978865 
    chicken
    (Gallus gallus)    		 Aves SPRTN1 SprT-like N-terminal domain 58.58(n)
    52.32(a)    		   421530  XM_419571.3  XP_419571.2 
    lizard
    (Anolis carolinensis)    		 Reptilia C1orf1246
    		 --
    		 53(a)
    		 1 ↔ 1
    		 1(221751682-221761232)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX843701.12   -- 76.54(n)    BX843701.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii fam89a1 family with sequence similarity 89, member A 60.62(n)
    59.52(a)    		   568145  XM_002665651.2  XP_002665697.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG92036
    		 --
    		 19(a)
    		 1 ↔ 1
    		 X(15366837-15369433)
    worm
    (Caenorhabditis elegans)    		 Secernentea T19B10.66
    		 Protein T19B10.6
    		 43(a)
    		 1 ↔ 1
    		 V(11237420-11239305)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    		 expressed protein
    		 16(a)
    13(a)
    		 many → 1
    many → 1
    		 3(6289728-6294363)
    9(14367031-14372668)


    ENSEMBL Gene Tree for SPRTN (if available)
    TreeFam Gene Tree for SPRTN (if available) 

    Paralogs
    for SPRTN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SPRTN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/315 NCBI SNPs in SPRTN are shown (see all 315)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2014830781,2
    		--231473503(+) CCGGGA/TCTCAC 4 -- us2k1 ut510--------
    rs2006478511,2
    		--231473525(+) CACTAC/TCGGCG 4 -- us2k1 ut510--------
    rs1922424831,2
    		--231473593(+) GAAGCA/GGGAAT 4 -- us2k10--------
    rs1113982851,2
    		--231473696(+) ATGCCA/GTCGGT 4 -- us2k1 ut512Minor allele frequency- G:0.04CSA EA 122
    rs1502925081,2
    		--231473757(+) CCGAGA/CGAAAT 4 -- ut51 us2k10--------
    rs1846240971,2
    		--231473789(+) AGCGTA/GACGTT 4 -- us2k1 ut510--------
    rs1122636801,2
    		--231473811(+) TAACCG/CGCAAA 4 -- us2k1 ut512Minor allele frequency- C:0.05CSA WA 120
    rs786581571,2
    		F,--231473839(+) AGCTTC/GCTGAA 4 -- ut51 us2k12Minor allele frequency- G:0.02NA EA 240
    rs1885208841,2
    		C,--231474100(+) GACGCC/GGGCGG 4 -- ut51 us2k10--------
    rs1379491151,2
    		C,--231474156(+) GCACTG/TCGGCT 7 L syn1 us2k10--------

    HapMap Linkage Disequilibrium report for SPRTN (231472850 - 231490769 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SPRTN: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRTN
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRTN

    Disorders / Diseases
    for SPRTN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPRTN for disorders           About GeneDecksing

    1 disease for SPRTN:    About MalaCards
    malaria


    Export disorders for SPRTN gene to outside databases

    Publications
    for SPRTN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRTN gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with SPRTN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response. (PubMed id 22681887)1, 2, 3 Centore R.C....Zou L. (2012)
    2. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. (PubMed id 22902628)1, 2 Ghosal G.... Chen J. (2012)
    3. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. (PubMed id 23042605)1, 2 Mosbech A.... Mailand N. (2012)
    4. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. (PubMed id 23042607)1, 2 Davis E.J....Rouse J. (2012)
    5. Spartan/C1orf124 is important to prevent UV-induced mutagenesis. (PubMed id 22894931)1, 2 Machida Y.... Machida Y.J. (2012)
    6. Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance. (PubMed id 22987070)1, 2 Juhasz S.... Haracska L. (2012)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for SPRTN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPRTN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83932 HGNC: 25356 AceView: DKFZP547N043 Ensembl:ENSG00000010072 euGenes: HUgn83932
    ECgene: SPRTN H-InvDB: SPRTN

    Other Databases showing SPRTN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPRTN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRTN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPRTN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPRTN gene:
    Search GeneIP for patents involving SPRTN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SPRTN gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SPRTN  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRTN   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRTN  
     OriGene Protein Over-expression Lysate for SPRTN   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SPRTN   OriGene 3'-UTR Clone for SPRTN  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRTN   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRTN  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPRTN   OriGene Custom Protein Services for SPRTN  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRTN
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRTN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRTN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRTN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRTN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRTN
     GenScript Custom Purified and Recombinant Proteins Services for SPRTN GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for SPRTN
     GenScript Custom Assay Services for SPRTN GenScript Custom Superior Antibodies Services for SPRTN
     GenScript Custom overexpressing Cell Line Services for SPRTN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for SPRTN
     Search Chromatin IP Primers for SPRTN
     Search RT2 qPCR Primer Assays in human, mouse, rat SPRTN
     Search GNC Networks for SPRTN
     SABiosciences Custom PCR Arrays for SPRTN
     Search Tocris compounds for SPRTN
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPRTN antibodies
     SPRTN proteins
     SPRTN lysates
     Search for Antibodies for SPRTN at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SPRTN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SPRTN Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SPRTN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRTN
     SwitchGear 3'UTR luciferase reporter plasmids for SPRTN
     SwitchGear Promoter luciferase reporter plasmids for SPRTN
     Search ThermoFisher Antibodies for SPRTN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRTN
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SPRTN gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4