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Aliases for SPRR4 Gene

Aliases for SPRR4 Gene

  • Small Proline Rich Protein 4 2 3
  • Small Proline-Rich Protein 4 2 5

External Ids for SPRR4 Gene

Previous GeneCards Identifiers for SPRR4 Gene

  • GC01M148727
  • GC01P149718
  • GC01P150159
  • GC01P149756
  • GC01P151209
  • GC01P124306

Summaries for SPRR4 Gene

GeneCards Summary for SPRR4 Gene

SPRR4 (Small Proline Rich Protein 4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPRR4 Gene

  • Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR4 Gene

Genomics for SPRR4 Gene

Regulatory Elements for SPRR4 Gene

Genomic Location for SPRR4 Gene

152,970,653 bp from pter
152,972,574 bp from pter
1,922 bases
Plus strand

Genomic View for SPRR4 Gene

Genes around SPRR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR4 Gene

Proteins for SPRR4 Gene

  • Protein details for SPRR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small proline-rich protein 4
    Protein Accession:
    Secondary Accessions:
    • Q2M1Y7
    • Q5T522

    Protein attributes for SPRR4 Gene

    79 amino acids
    Molecular mass:
    8793 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR4 Gene

Proteomics data for SPRR4 Gene at MOPED

Post-translational modifications for SPRR4 Gene

Other Protein References for SPRR4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR4 Gene

Domains & Families for SPRR4 Gene

Protein Domains for SPRR4 Gene


Suggested Antigen Peptide Sequences for SPRR4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cornifin (SPRR) family.
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR4: view

No data available for Gene Families for SPRR4 Gene

Function for SPRR4 Gene

Molecular function for SPRR4 Gene

UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.
UniProtKB/Swiss-Prot Induction:
By UV irradiation.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRR4 Gene

Localization for SPRR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR4 Gene

Cytoplasm. Cytoplasm, cell cortex. Note=Translocates to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes.

Subcellular locations from

Jensen Localization Image for SPRR4 Gene COMPARTMENTS Subcellular localization image for SPRR4 gene
Compartment Confidence
cytosol 3
extracellular 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SPRR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with SPRR4: view

Pathways & Interactions for SPRR4 Gene

SuperPathways for SPRR4 Gene

No Data Available

Interacting Proteins for SPRR4 Gene

Gene Ontology (GO) - Biological Process for SPRR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018149 peptide cross-linking IBA --
genes like me logo Genes that share ontologies with SPRR4: view

No data available for Pathways by source and SIGNOR curated interactions for SPRR4 Gene

Drugs & Compounds for SPRR4 Gene

No Compound Related Data Available

Transcripts for SPRR4 Gene

mRNA/cDNA for SPRR4 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR4 Gene

Small proline-rich protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR4 Gene

No ASD Table

Relevant External Links for SPRR4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRR4 Gene

mRNA expression in normal human tissues for SPRR4 Gene

mRNA differential expression in normal tissues according to GTEx for SPRR4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x32.1) and Skin - Sun Exposed (Lower leg) (x17.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRR4 Gene

SOURCE GeneReport for Unigene cluster for SPRR4 Gene Hs.433629

genes like me logo Genes that share expression patterns with SPRR4: view

Protein tissue co-expression partners for SPRR4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPRR4 Gene

Orthologs for SPRR4 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SPRR4 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Sprr4 36
  • 72 (a)
(Pan troglodytes)
Mammalia SPRR4 36
  • 96 (a)
Species with no ortholog for SPRR4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR4 Gene

Gene Tree for SPRR4 (if available)
Gene Tree for SPRR4 (if available)

Paralogs for SPRR4 Gene

(3) SIMAP similar genes for SPRR4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPRR4: view

No data available for Paralogs for SPRR4 Gene

Variants for SPRR4 Gene

Sequence variations from dbSNP and Humsavar for SPRR4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs16834786 - 152,972,023(+) AGGAT(C/T)CATGT reference, missense
rs883809 -- 152,968,915(-) AACTA(C/T)GCAGC upstream-variant-2KB
rs883810 -- 152,968,869(-) CATAT(A/G)CCTGG upstream-variant-2KB
rs1890284 -- 152,969,714(+) CATAT(A/G)AACTA upstream-variant-2KB
rs3170863 -- 152,972,118(+) AAGAG(C/T)AAACA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SPRR4 Gene

Variant ID Type Subtype PubMed ID
nsv831592 CNV Gain 17160897

Variation tolerance for SPRR4 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRR4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR4 Gene

Disorders for SPRR4 Gene

Relevant External Links for SPRR4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPRR4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR4 Gene

Publications for SPRR4 Gene

  1. SPRR4, a novel cornified envelope precursor: UV-dependent epidermal expression and selective incorporation into fragile envelopes. (PMID: 11719550) Cabral A. … Backendorf C. (J. Cell Sci. 2001) 2 3 4 67
  2. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 2 3 23
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PMID: 18643845) Kainu K. … Saarialho-Kere U. (Exp. Dermatol. 2009) 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3

Products for SPRR4 Gene

Sources for SPRR4 Gene

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