SPRR4 Gene
protein-coding GIFtS: 39
GCID: GC01P152943
|
|
small proline-rich protein 4
| |
Aliases
for SPRR4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Proline-Rich Protein 41 2 | | Small Proline Rich Protein 42 |
Export aliases for SPRR4 gene to outside databasesPrevious GC identifers: GC01M148727 GC01P149718 GC01P150159 GC01P149756 GC01P151209 GC01P124306 |
Summaries
for SPRR4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPRR4_HUMAN, Q96PI1Function: Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification
|
Genomic Views
for SPRR4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPRR4 gene promoter:
HOXA9B ER-alpha ISGF-3 NCX/Ncx Olf-1 FOXC1 SEF-1 (1) Meis-1a En-1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPRR4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3SPRR4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P152943: view genomic region
(about GC identifiers)
Start:
|
152,943,128 bp from pter |
End:
|
152,945,069 bp from pter |
Size:
|
1,942 bases |
Orientation:
|
plus strand |
|
Proteins
for SPRR4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPRR4_HUMAN, Q96PI1 (See
protein sequence)Recommended Name: Small proline-rich protein 4 Size: 79 amino acids; 8793 Da
Subcellular location: Cytoplasm. Cytoplasm, cell cortex. Note=Translocates to the cell periphery of keratinocytes andis integrated into both rigid and fragile cornified envelopes
Secondary accessions: Q2M1Y7 Q5T522Explore the universe of human proteins at neXtProt for SPRR4: NX_Q96PI1
Post-translational modifications:
Cross-linked to membrane proteins by transglutaminase (Probable)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PI1
SPRR4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775103.1
ENSEMBL proteins: ENSP00000332163
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005938 | cell cortex |
IEA | -- |
SPRR4 for ontologies About GeneDecksing
SPRR4 Antibody Products:
Assay Products for SPRR4: |
Protein
Domains /
Families
for SPRR4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPRR4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PI1ProtoNet protein and cluster: Q96PI1 UniProtKB/Swiss-Prot: SPRR4_HUMAN, Q96PI1Similarity: Belongs to the cornifin (SPRR) family |
Function
for SPRR4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPRR4_HUMAN, Q96PI1Function: Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornificationInduction: By UV irradiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPRR4 (NM_173080) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR4 |
|
Pathways & Interactions
for SPRR4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRR4
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0018149 | peptide cross-linking |
IEA | -- | | GO:0031424 | keratinization |
IEA | -- |
SPRR4 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPRR4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPRR4
Search CenterWatch for drugs/clinical trials and news about SPRR4
|
Transcripts
for SPRR4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPRR4 gene: NM_173080.1 Unigene Cluster for SPRR4: Small proline-rich protein 4 Hs.433629 [show with all ESTs]Unigene Representative Sequence: BG1907581 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000328051(uc001fav.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPRR4 (NM_173080) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR4 |
Additional cDNA sequence: BC069445.1 BC069549.1 BC112170.1 BC112172.1 2 DOTS entries: DT.95113183 DT.209448 22 AceView cDNA sequences: AI250771 AA339786 AI125483 W73951 NM_173080 W94063 BC069549 AA912611 AA777158 AI161017 W77994 BG181820 BC069445 AW961118 BG190758 AA339877 BF371044 BE716625 BE716719 AI265865 BE838395 BE716636
GeneLoc Exon Structure
|
Expression
for SPRR4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPRR4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPRR4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRR4
SOURCE GeneReport for Unigene cluster: Hs.433629
SABiosciences Custom PCR Arrays for SPRR4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRR4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPRR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR4 |
Orthologs
for SPRR4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for SPRR4 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for SPRR4 (if available)
TreeFam Gene Tree for SPRR4 (if available) |
Paralogs
for SPRR4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPRR4 gene
- SPRR1B2 SPRR2F2 SPRR2B2 SPRR2D2 SPRR2G2 SPRR2A2 SPRR1A2 SPRR2E2
- LELP12 SPRR32
3 SIMAP similar genes for SPRR4 using alignment to 1 protein entry: SPRR4_HUMAN:SPRR1B SPRR1A PRR9
SPRR4 for paralogs About GeneDecksing
|
Genomic Variants
for SPRR4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPRR4 (152943128 - 152945069 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPRR4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR4 |
|
Disorders
/ Diseases
for SPRR4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPRR4 for disorders About GeneDecksing
1  disease for SPRR4: About MalaCardspsoriasis
Export disorders for SPRR4 gene to outside databases
|
Publications
for SPRR4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPRR4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPRR4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- SPRR4, a novel cornified envelope precursor: UV-dependent epidermal expression and selective incorporation into fragile envelopes. (PubMed id 11719550)1, 2, 3 Cabral A....Backendorf C. (2001)
- Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PubMed id 11279051)1, 3, 9 Cabral A....Backendorf C. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PubMed id 18643845)1 Kainu K....Saarialho-Kere U. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SPRR4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPRR4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPRR4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPRR4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPRR4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPRR4 gene:
Search GeneIP for patents involving SPRR4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPRR4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPRR4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRR4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRR4 | | | OriGene Protein Over-expression Lysate for SPRR4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPRR4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPRR4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPRR4 | | OriGene Custom Protein Services for SPRR4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRR4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR4 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SPRR4 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SPRR4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR4 |
|  |  |  | | | | Search ThermoFisher Antibodies for SPRR4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR4 |
|
|
|
|
