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Aliases for SPRR3 Gene

Aliases for SPRR3 Gene

  • Small Proline-Rich Protein 3 2 3
  • 22 KDa Pancornulin 3 4
  • Cornifin Beta 3 4
  • Esophagin 3 4
  • SPRC 4

External Ids for SPRR3 Gene

Previous GeneCards Identifiers for SPRR3 Gene

  • GC01P150790
  • GC01P148756
  • GC01P149749
  • GC01P150190
  • GC01P149787
  • GC01P151240
  • GC01P152974
  • GC01P124337

Summaries for SPRR3 Gene

GeneCards Summary for SPRR3 Gene

SPRR3 (Small Proline-Rich Protein 3) is a Protein Coding gene. Diseases associated with SPRR3 include esophagitis. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SPRR1B.

UniProtKB/Swiss-Prot for SPRR3 Gene

  • Cross-linked envelope protein of keratinocytes

Gene Wiki entry for SPRR3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR3 Gene

Genomics for SPRR3 Gene

Regulatory Elements for SPRR3 Gene

Genomic Location for SPRR3 Gene

153,001,747 bp from pter
153,003,856 bp from pter
2,110 bases
Plus strand

Genomic View for SPRR3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR3 Gene

Proteins for SPRR3 Gene

  • Protein details for SPRR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small proline-rich protein 3
    Protein Accession:
    Secondary Accessions:
    • A5YKK8
    • B2R4G8
    • D3DV32
    • O75597
    • Q4ZGI7
    • Q5T525
    • Q8NET7
    • Q9UDG3

    Protein attributes for SPRR3 Gene

    169 amino acids
    Molecular mass:
    18154 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR3 Gene

Proteomics data for SPRR3 Gene at MOPED

Post-translational modifications for SPRR3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRR3 Gene

No data available for DME Specific Peptides for SPRR3 Gene

Domains for SPRR3 Gene

Protein Domains for SPRR3 Gene

Suggested Antigen Peptide Sequences for SPRR3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9UBC9
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR3: view

No data available for Gene Families for SPRR3 Gene

Function for SPRR3 Gene

Molecular function for SPRR3 Gene

GENATLAS Biochemistry: small proline rich protein 3,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function: Cross-linked envelope protein of keratinocytes
UniProtKB/Swiss-Prot Induction: During squamous differentiation of epidermal keratinocytes

Gene Ontology (GO) - Molecular Function for SPRR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 9889002
GO:0005515 protein binding IPI 10510474
genes like me logo Genes that share ontologies with SPRR3: view

Animal Model Products

miRNA for SPRR3 Gene

miRTarBase miRNAs that target SPRR3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPRR3 Gene

Localization for SPRR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR3 Gene


Subcellular locations from

Jensen Localization Image for SPRR3 Gene COMPARTMENTS Subcellular localization image for SPRR3 gene
Compartment Confidence
cytosol 3
extracellular 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SPRR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SPRR3: view

Pathways for SPRR3 Gene

SuperPathways for SPRR3 Gene

No Data Available

Interacting Proteins for SPRR3 Gene

Gene Ontology (GO) - Biological Process for SPRR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0018149 peptide cross-linking IEA --
GO:0030216 keratinocyte differentiation NAS 8325635
GO:0031424 keratinization IEA --
GO:0042060 wound healing TAS 10510474
genes like me logo Genes that share ontologies with SPRR3: view

No data available for Pathways by source for SPRR3 Gene

Compounds for SPRR3 Gene

(3) Novoseek inferred chemical compound relationships for SPRR3 Gene

Compound -log(P) Hits PubMed IDs
proline 58 3
retinoic acid 21.3 2
calcium 0 1
genes like me logo Genes that share compounds with SPRR3: view

Transcripts for SPRR3 Gene

Unigene Clusters for SPRR3 Gene

Small proline-rich protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP3: - -

Relevant External Links for SPRR3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRR3 Gene

mRNA expression in normal human tissues for SPRR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRR3 Gene

This gene is overexpressed in Esophagus - Mucosa (29.1), Vagina (10.2), Cervix - Ectocervix (8.8), and Minor Salivary Gland (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRR3 Gene

SOURCE GeneReport for Unigene cluster for SPRR3 Gene Hs.139322

genes like me logo Genes that share expressions with SPRR3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPRR3 Gene

Orthologs for SPRR3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPRR3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRR3 35
  • 98.55 (n)
  • 96.89 (a)
SPRR3 36
  • 96 (a)
(Bos Taurus)
Mammalia SPRR3 36
  • 67 (a)
(Canis familiaris)
Mammalia LOC100685649 35
  • 77.25 (n)
  • 70.59 (a)
SPRR3 36
  • 37 (a)
(Mus musculus)
Mammalia Sprr3 35
  • 68.86 (n)
  • 52.69 (a)
Sprr3 16
Sprr3 36
  • 38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
(Rattus norvegicus)
Mammalia Sprr3 35
  • 68.04 (n)
  • 51.24 (a)
Species with no ortholog for SPRR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR3 Gene

Gene Tree for SPRR3 (if available)
Gene Tree for SPRR3 (if available)

Paralogs for SPRR3 Gene

Paralogs for SPRR3 Gene

Selected SIMAP similar genes for SPRR3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPRR3: view

Variants for SPRR3 Gene

Sequence variations from dbSNP and Humsavar for SPRR3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946097 -- 153,002,256(+) TCAGG(A/G)AGGAC intron-variant
rs946098 -- 153,002,562(+) CAGGG(A/C)AGAGC intron-variant
rs1015995 -- 153,003,638(-) GGTGA(C/G)AATGT utr-variant-3-prime
rs1015996 -- 153,003,632(-) AATGT(A/G)CTGAT utr-variant-3-prime
rs1055935 - 153,003,465(-) TGGTA(C/G)CTTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPRR3 Gene

Variant ID Type Subtype PubMed ID
nsv831592 CNV Gain 17160897

Relevant External Links for SPRR3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR3 Gene

Disorders for SPRR3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SPRR3 Gene including...

Search for SPRR3 Gene in MalaCards »

(4) Novoseek inferred disease relationships for SPRR3 Gene

Disease -log(P) Hits PubMed IDs
esophageal carcinoma 44.4 2
skin diseases 37.6 3
carcinoma squamous cell 30.4 2
cancer 0 2
genes like me logo Genes that share disorders with SPRR3: view

No data available for UniProtKB/Swiss-Prot for SPRR3 Gene

Publications for SPRR3 Gene

  1. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3 4 23
  2. Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors. (PMID: 8809402) Abraham J.M. … Meltzer S.J. (Cell Growth Differ. 1996) 3 4 23
  3. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 3 23
  4. Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression. (PMID: 15221970) Kimos M.C. … Meltzer S.J. (Int. J. Cancer 2004) 3 23
  5. Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein. (PMID: 10510474) Steinert P.M. … Melino G. (Cell Death Differ. 1999) 3 23

Products for SPRR3 Gene

Sources for SPRR3 Gene

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