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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRR3 Gene

protein-coding   GIFtS: 52
GCID: GC01P152974

Small Proline-Rich Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Proline-Rich Protein 31 2
Cornifin Beta2 3
22 KDa Pancornulin2 3
esophagin2
Esophagin3
SPRC3

External Ids:    HGNC: 112681   Entrez Gene: 67072   Ensembl: ENSG000001632097   OMIM: 1822715   UniProtKB: Q9UBC93   

Export aliases for SPRR3 gene to outside databases

Previous GC identifers: GC01P150790 GC01P148756 GC01P149749 GC01P150190 GC01P149787 GC01P151240 GC01P124337


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPRR3 Gene: 
SPRR3 (small proline-rich protein 3) is a protein-coding gene. Diseases associated with SPRR3 include eosinophilic esophagitis, and verrucous carcinoma. GO annotations related to this gene include protein binding and structural molecule activity. An important paralog of this gene is SPRR1B.

UniProtKB/Swiss-Prot: SPRR3_HUMAN, Q9UBC9
Function: Cross-linked envelope protein of keratinocytes

Gene Wiki entry for SPRR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRR3 gene promoter:
         p300   LCR-F1   Ik-3   E47   C/EBPalpha   AREB6   Hand1   ZID   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21-q22

SPRR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P152974:  view genomic region     (about GC identifiers)

Start:
152,974,223 bp from pter      End:
152,976,332 bp from pter
Size:
2,110 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPRR3_HUMAN, Q9UBC9 (See protein sequence)
Recommended Name: Small proline-rich protein 3  
Size: 169 amino acids; 18154 Da
Subcellular location: Cytoplasm
Mass spectrometry: Mass=17239; Method=Electrospray; Range=2-169; Note=Variants Del 98-Cys--Pro-105 and Val-149;
Source=PubMed:20599699;
Mass spectrometry: Mass=18065; Method=Electrospray; Range=2-169; Source=PubMed:20599699;
Secondary accessions: A5YKK8 B2R4G8 D3DV32 O75597 Q4ZGI7 Q5T525 Q8NET7 Q9UDG3

Explore the universe of human proteins at neXtProt for SPRR3: NX_Q9UBC9

Explore proteomics data for SPRR3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UBC9

  • SPRR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPRR3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001091058.1  NP_005407.1  

    ENSEMBL proteins: 
     ENSP00000402016   ENSP00000295367   ENSP00000330391   ENSP00000441477  

    Human Recombinant Protein Products for SPRR3: 
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    Novus Biologicals SPRR3 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPRR3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    SPRR3 for ontologies           About GeneDecksing



    SPRR3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for SPRR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026075 SPRR/LCE
     IPR003302 Cornifin

    Graphical View of Domain Structure for InterPro Entry Q9UBC9

    ProtoNet protein and cluster: Q9UBC9

    2 Blocks protein domains:
    IPB003267 Small proline-rich protein signature
    IPB003302 Cornifin (SPRR)


    UniProtKB/Swiss-Prot: SPRR3_HUMAN, Q9UBC9
    Similarity: Belongs to the cornifin (SPRR) family


    SPRR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRR3_HUMAN, Q9UBC9
    Function: Cross-linked envelope protein of keratinocytes
    Induction: During squamous differentiation of epidermal keratinocytes

         Genatlas biochemistry entry for SPRR3:
    small proline rich protein 3,precursor of cornified cell envelope,cornifin,clustered in the epidermal
    differentiation complex (EDC)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity TAS9889002
    GO:0005515protein binding IPI10510474
         
    SPRR3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPRR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRR3 
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    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRR3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRR3:
    hsa-miR-651 hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidSPRR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRR3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SPRR3 (Q9UBC93 ENSP000002953674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IVLP074763, ENSP000003577534I2D: score=1 STRING: ENSP00000357753
    EVPLQ928173, ENSP000003016074I2D: score=1 STRING: ENSP00000301607
    NFKBIAP259633, ENSP000002167974I2D: score=1 STRING: ENSP00000216797
    LORENSP000003577314STRING: ENSP00000357731
    --O603543I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development NAS8325635
    GO:0018149peptide cross-linking IEA--
    GO:0030216keratinocyte differentiation NAS8325635
    GO:0031424keratinization IEA--
    GO:0042060wound healing TAS10510474

    SPRR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPRR3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRR3

    3 Novoseek inferred chemical compound relationships for SPRR3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 58 3 8809402 (1), 10510474 (1), 8631988 (1)
    retinoic acid 21.3 3 7769256 (1), 8631988 (1)
    calcium 0 1 8618063 (1)

    Search CenterWatch for drugs/clinical trials and news about SPRR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRR3 gene (2 alternative transcripts): 
    NM_001097589.1  NM_005416.2  

    Unigene Cluster for SPRR3:

    Small proline-rich protein 3
    Hs.139322  [show with all ESTs]
    Unigene Representative Sequence: EF553525
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495845 ENST00000443178 ENST00000295367 ENST00000331860(uc001fax.4 uc001faz.4 uc001fay.2)
    ENST00000542696
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRR3:
    hsa-miR-651 hsa-miR-624
    SwitchGear 3'UTR luciferase reporter plasmidSPRR3 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR3

    Additional mRNA sequence: 

    AJ243667.1 AK309626.1 AK311823.1 AY118269.1 BC017802.1 EF553525.1 

    5 DOTS entries:

    DT.40265322  DT.95261914  DT.91766932  DT.92003597  DT.91798410 

    24/114 AceView cDNA sequences (see all 114):

    AW204307 AL602972 AA583900 AL602918 AA583886 NM_005987 CD704302 AW082445 
    BM955457 AA595962 BM955470 BE183773 BX505203 AW135266 BM955466 BM955461 
    AW366290 BM955472 AA583834 AW872962 AA366720 AY118269 BM955459 NM_005416 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPRR3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
    SP1:              -                     
    SP2:                                    
    SP3:              -     -               


    ECgene alternative splicing isoforms for SPRR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRR3 expression in normal human tissues (normalized intensities)      SPRR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCCTGCTC
    SPRR3 Expression
    About this image


    SPRR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 5 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Basal Cells Respiratory Bronchioles
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             Tongue   
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Human EpiDermal Melanocytes-medium (HEM-m)   
     
     Melanocytes (Integumentary System)
             Human EpiDermal Melanocytes-medium (HEM-m)   

    See SPRR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRR3

    SOURCE GeneReport for Unigene cluster: Hs.139322
        SABiosciences Custom PCR Arrays for SPRR3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SPRR3 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sprr35
    Sprr1b1
    small proline-rich protein 35
    small proline-rich protein 1B1
    67.1(n)1
    58.17(a)1
      3 (40.14 cM)5
    207541  NM_009265.31  NP_033291.11 
     924565025 


    ENSEMBL Gene Tree for SPRR3 (if available)
    TreeFam Gene Tree for SPRR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPRR3 gene
    SPRR1B2  SPRR1A2  
    2 SIMAP similar genes for SPRR3 using alignment to 3 protein entries:     SPRR3_HUMAN (see all proteins):
    SPRR1B    SPRR1A

    SPRR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/206 SNPs in SPRR3 are shown (see all 206)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453908861,2
    --152972255(+) AAGTCC/TCAAGA 2 -- us2k10--------
    rs1379372521,2
    C--152972357(+) GACTCA/G/TCCTTC 2 -- us2k10--------
    rs1494760451,2
    --152972380(+) ATGTAA/TCCTCT 2 -- us2k10--------
    rs289247111,2
    C,F--152972382(+) GTATCC/GTCTCT 2 -- us2k16Minor allele frequency- G:0.01NS WA 308
    rs1873569111,2
    --152972388(+) TCTCTA/TAAACT 2 -- us2k10--------
    rs1438793551,2
    --152972455(+) AAAGAC/GGCTTA 2 -- us2k10--------
    rs1486069181,2
    --152972471(+) CAGGCA/GCTGAG 2 -- us2k10--------
    rs289247121,2
    C,F--152972503(+) AACAGG/CGTTGG 2 -- us2k15Minor allele frequency- C:0.00NS 190
    rs38062191,2
    C,F,A,H--152972522(+) GAGAAC/TTTCAA 2 -- us2k136Minor allele frequency- T:0.42EA NA NS WA CSA 4224
    rs289247131,2
    C,F--152972544(+) CAGAGA/CAGCTT 2 -- us2k16Minor allele frequency- C:0.02NS WA 308

    HapMap Linkage Disequilibrium report for SPRR3 (152974223 - 152976332 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SPRR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831592CNV Gain17160897


    Human Gene Mutation Database (HGMD): SPRR3
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRR3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182271    OMIM disorders: --

    15 diseases for SPRR3:    About MalaCards
    eosinophilic esophagitis    verrucous carcinoma    ichthyosis vulgaris    skin disease
    esophagitis    eczema    tonsillitis    ichthyosis
    esophageal cancer    esophageal squamous cell carcinoma    periodontitis    psoriasis
    squamous cell carcinoma    endotheliitis    breast cancer


    SPRR3 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for SPRR3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    esophageal carcinoma 44.4 3 11133802 (2)
    skin diseases 37.6 5 9008234 (2), 11069449 (1)
    carcinoma squamous cell 30.4 2 9008234 (1), 11069449 (1)
    cancer 0 4 11133802 (2)


    Export disorders for SPRR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRR3 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with SPRR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PubMed id 8325635)1, 2, 3, 9 Gibbs S.... Backendorf C. (1993)
    2. Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors. (PubMed id 8809402)1, 2, 9 Abraham J.M.... Meltzer S.J. (1996)
    3. Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and sub mandibular gland samples. (PubMed id 20599699)1, 2 Manconi B....Messana I. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)1, 2 Marenholz I....Mischke D. (2001)
    7. The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation. (PubMed id 7829876)1, 2 Greco M.A....Kvedar J.C. (1995)
    8. Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts. (PubMed id 8018055)1, 2 Robinson P.A.... Hume W.J. (1994)
    9. Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. (PubMed id 18832573)1, 9 Pyle A.L....Young P.P. (2008)
    10. Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression. (PubMed id 15221970)1, 9 Kimos M.C....Meltzer S.J. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6707 HGNC: 11268 AceView: SPRR3andSPRR1A Ensembl:ENSG00000163209 euGenes: HUgn6707
    ECgene: SPRR3 H-InvDB: SPRR3

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRR3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sprr3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPRR3 gene:
    Search GeneIP for patents involving SPRR3

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