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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPRR3 Gene

protein-coding GIFtS: 51
GCID: GC01P152974

small proline-rich protein 3

Explore 15 diseases affiliated with
SPRR3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Small Proline-Rich Protein 3¹ ²
Cornifin Beta² ³
22 KDa Pancornulin² ³
Esophagin³
Esophagin³
SPRC³

External Ids:	HGNC: 11268¹	Entrez Gene: 6707²	Ensembl: ENSG00000163209⁷	OMIM: 182271⁵	UniProtKB: Q9UBC9³

Export aliases for SPRR3 gene to outside databases

Previous GC identifers: GC01P150790 GC01P148756 GC01P149749 GC01P150190 GC01P149787 GC01P151240 GC01P124337

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPRR3_HUMAN, Q9UBC9

Function: Cross-linked envelope protein of keratinocytes

Gene Wiki entry for SPRR3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPRR3 gene promoter:
p300 LCR-F1 Ik-3 E47 C/EBPalpha AREB6 Hand1 ZID Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPRR3 promoter sequence

Search SABiosciences Chromatin IP Primers for SPRR3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21-q22

SPRR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRR3 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P152974: view genomic region (about GC identifiers)

Start:	152,974,223 bp from pter	End:	152,976,332 bp from pter
Size:	2,110 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPRR3_HUMAN, Q9UBC9 (See protein sequence)

Recommended Name: Small proline-rich protein 3

Size: 169 amino acids; 18154 Da

Subcellular location: Cytoplasm

Mass spectrometry: Mass=17239; Method=Electrospray; Range=2-169; Note=Variants Del 98-Cys--Pro-105 and Val-149;

Source=PubMed:20599699;

Mass spectrometry: Mass=18065; Method=Electrospray; Range=2-169; Source=PubMed:20599699;

Secondary accessions: A5YKK8 B2R4G8 D3DV32 O75597 Q4ZGI7 Q5T525 Q8NET7 Q9UDG3

Explore the universe of human proteins at neXtProt for SPRR3: NX_Q9UBC9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UBC9

SPRR3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001091058.1 NP_005407.1

ENSEMBL proteins:

ENSP00000402016 ENSP00000295367 ENSP00000330391 ENSP00000441477

Human Recombinant Protein Products for SPRR3:

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	Uscn Proteins for SPRR3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

SPRR3 for ontologies About GeneDecksing

SPRR3 Antibody Products:

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	Uscn ELISAs and CLIAs for SPRR3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPRR3 for domains About GeneDecksing

2 InterPro domains/families:

IPR003302 Cornifin

IPR026075 SPRR/LCE

Graphical View of Domain Structure for InterPro Entry Q9UBC9

ProtoNet protein and cluster: Q9UBC9

2 Blocks protein families:

IPB003267 Small proline-rich protein signature

IPB003302 Cornifin (SPRR)

UniProtKB/Swiss-Prot: SPRR3_HUMAN, Q9UBC9

Similarity: Belongs to the cornifin (SPRR) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SPRR3_HUMAN, Q9UBC9

Function: Cross-linked envelope protein of keratinocytes

Induction: During squamous differentiation of epidermal keratinocytes

Genatlas biochemistry entry for SPRR3:

small proline rich protein 3,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation

complex (EDC)

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	TAS	9889002
GO:0005515	protein binding	IPI	10510474

SPRR3 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPRR3

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRR3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRR3:
		hsa-miR-651 hsa-miR-624
		SwitchGear 3'UTR luciferase reporter plasmid: SPRR3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRR3 (see all 7) OriGene shRNA RFP: SPRR3 OriGene siRNA: SPRR3
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPRR3

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5 Interacting proteins for SPRR3 (Q9UBC9³ ENSP00000295367⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IVL	P07476³, ENSP00000357753⁴	I2D: score=1 STRING: ENSP00000357753
EVPL	Q92817³, ENSP00000301607⁴	I2D: score=1 STRING: ENSP00000301607
NFKBIA	P25963³, ENSP00000216797⁴	I2D: score=1 STRING: ENSP00000216797
LOR	ENSP00000357731⁴	STRING: ENSP00000357731
--	O60354³	I2D: score=1

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008544	epidermis development	NAS	8325635
GO:0018149	peptide cross-linking	IEA	--
GO:0030216	keratinocyte differentiation	NAS	8325635
GO:0031424	keratinization	IEA	--
GO:0042060	wound healing	TAS	10510474

SPRR3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SPRR3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPRR3
3 Novoseek chemical compound relationships for SPRR3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
proline	58	3	8809402 (1), 10510474 (1), 8631988 (1)
retinoic acid	21.3	3	7769256 (1), 8631988 (1)
calcium	0	1	8618063 (1)

Search CenterWatch for drugs/clinical trials and news about SPRR3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPRR3 gene (2 alternative transcripts):

NM_001097589.1 NM_005416.2

Unigene Cluster for SPRR3:

Small proline-rich protein 3

Hs.139322 [show with all ESTs]

Unigene Representative Sequence: EF553525

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000495845 ENST00000443178 ENST00000295367 ENST00000331860(uc001fax.4 uc001faz.4 uc001fay.2)

ENST00000542696

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRR3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRR3:
		hsa-miR-651 hsa-miR-624
		SwitchGear 3'UTR luciferase reporter plasmid: SPRR3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRR3 (see all 7) OriGene shRNA RFP: SPRR3 OriGene siRNA: SPRR3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR3
		Sirion Biotech Custom design and validation of potent shRNA sequences against SPRR3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR3 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR3 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SPRR3 (NM_001097589)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRR3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRR3 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR3

Additional cDNA sequence:

AJ243667.1 AK309626.1 AK311823.1 AY118269.1 BC017802.1 EF553525.1

5 DOTS entries:

DT.40265322 DT.95261914 DT.91766932 DT.92003597 DT.91798410

24/114 AceView cDNA sequences (see all 114):

CD704302 AA583886 AL602918 AW204307 AL602972 AA583900 NM_005987 BE183773

AY118269 BM955457 AA583834 AA366720 AW366290 BM955459 BE713212 BX505203

BE925218 AA595962 BM955472 AW082445 AW135266 BM955466 BM955470 AW872962

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SPRR3 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b
SP1:					-
SP2:
SP3:					-		-

ECgene alternative splicing isoforms for SPRR3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPRR3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCCTGCTC

About this image

SPRR3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPRR3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRR3

SOURCE GeneReport for Unigene cluster: Hs.139322

SABiosciences Custom PCR Arrays for SPRR3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRR3 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for SPRR3 (if available)
TreeFam Gene Tree for SPRR3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPRR3 gene

SPRR1B² SPRR4² SPRR2F² SPRR2B² SPRR2D² SPRR2G² SPRR2A² SPRR1A²

SPRR2E² LELP1²

2 SIMAP similar genes for SPRR3 using alignment to 3 protein entries: SPRR3_HUMAN (see all proteins):

SPRR1B SPRR1A

SPRR3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs145390886^1,2		--	152972255(+)	`AAGTCC/TCAAGA`	2	--	us2k¹		0	--	--	--	--
rs137937252^1,2		--	152972357(+)	`GACTCA/GCCTTC`	2	--	us2k¹		0	--	--	--	--
rs149476045^1,2		--	152972380(+)	`ATGTAA/TCCTCT`	2	--	us2k¹		0	--	--	--	--
rs28924711^1,2	C	--	152972382(+)	`GTATCC/GTCTCT`	2	--	us2k¹		6		NS WA	308
rs187356911^1,2		--	152972388(+)	`TCTCTA/TAAACT`	2	--	us2k¹		0	--	--	--	--
rs143879355^1,2		--	152972455(+)	`AAAGAC/GGCTTA`	2	--	us2k¹		0	--	--	--	--
rs148606918^1,2		--	152972471(+)	`CAGGCA/GCTGAG`	2	--	us2k¹		0	--	--	--	--
rs28924712^1,2	C	--	152972503(+)	`AACAGG/CGTTGG`	2	--	us2k¹		5		NS	190
rs3806219^1,2	C,F,A,H	--	152972522(+)	`GAGAAC/TTTCAA`	2	--	us2k¹		36		EA NA NS WA CSA	4224
rs28924713^1,2	C,F	--	152972544(+)	`CAGAGA/CAGCTT`	2	--	us2k¹		6		NS WA	308

HapMap Linkage Disequilibrium report for SPRR3 (152974223 - 152976332 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPRR3: --
Human Gene Mutation Database (HGMD): SPRR3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR3

DNA2.0 Custom Variant and Variant Library Synthesis for SPRR3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPRR3 for disorders           About GeneDecksing

OMIM gene information: 182271    OMIM disorders: --

15 diseases for SPRR3:    About MalaCards

ichthyosis vulgaris esophageal squamous cell carcinoma eosinophilic esophagitis squamous cell carcinoma

verrucous carcinoma skin disease esophagitis esophageal carcinoma

ichthyosis eczema tonsillitis carcinoma

esophageal cancer periodontitis psoriasis

4 Novoseek disease relationships for SPRR3 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
esophageal carcinoma	44.4	3	11133802 (2)
skin diseases	37.6	5	9008234 (2), 11069449 (1)
carcinoma squamous cell	30.4	2	9008234 (1), 11069449 (1)
cancer	0	4	11133802 (2)

Export disorders for SPRR3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPRR3 gene, integrated from 9 sources (see all 48):
(articles sorted by number of sources associating them with SPRR3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PubMed id 8325635)^{1, 2, 3, 9} Gibbs S.... Backendorf C. (1993)
Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors. (PubMed id 8809402)^{1, 2, 9} Abraham J.M.... Meltzer S.J. (1996)
Characterization of two isoforms of human SPRR3 from saliva of preterm human newborn and autoptic fetal oral mucosa, parotid and sub mandibular gland samples. (PubMed id 20599699)^{1, 2} Manconi B....Messana I. (2010)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)^{1, 2} Marenholz I....Mischke D. (2001)
The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation. (PubMed id 7829876)^{1, 2} Greco M.A....Kvedar J.C. (1995)
Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts. (PubMed id 8018055)^{1, 2} Robinson P.A.... Hume W.J. (1994)
Regulation of the atheroma-enriched protein, SPRR3, in vascular smooth muscle cells through cyclic strain is dependent on integrin alpha1beta1/collagen interaction. (PubMed id 18832573)^{1, 9} Pyle A.L....Young P.P. (2008)
Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression. (PubMed id 15221970)^{1, 9} Kimos M.C....Meltzer S.J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6707	HGNC: 11268	AceView: SPRR3andSPRR1A	Ensembl:ENSG00000163209	euGenes: HUgn6707
ECgene: SPRR3	H-InvDB: SPRR3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPRR3	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/sprr3/

Intellectual Property for SPRR3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SPRR3 gene:
Search GeneIP for patents involving SPRR3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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SPRR3 Gene

small proline-rich protein 3

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SPRR3 Gene

small proline-rich protein 3

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Specialized Databases showing SPRR3 gene

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for SPRR3 gene

Genomic Views
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for SPRR3 gene

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Families
for SPRR3 gene

Function
for SPRR3 gene

Pathways & Interactions
for SPRR3 gene

Drugs & Compounds
for SPRR3 gene

Transcripts
for SPRR3 gene

Expression
for SPRR3 gene

Orthologs
for SPRR3 gene

Paralogs
for SPRR3 gene

Genomic Variants
for SPRR3 gene

Disorders / Diseases
for SPRR3 gene

Publications
for SPRR3 gene

Intellectual Property
for SPRR3 gene

Products
for SPRR3 gene