SPRR2G Gene
protein-coding GIFtS: 39
GCID: GC01M153122
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small proline-rich protein 2G
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Aliases
for SPRR2G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Proline-Rich Protein 2G1 2 | | SPR-2G2 3 |
Export aliases for SPRR2G gene to outside databasesPrevious GC identifers: GC01U990161 GC01M151379 GC01M151390 GC01M124485 |
Summaries
for SPRR2G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPR2G_HUMAN, Q9BYE4Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membrane (By similarity)
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Genomic Views
for SPRR2G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPRR2G gene promoter:
MEF-2A TBP C/EBPbeta Pbx1a ATF-2 aMEF-2 CUTL1 MRF-2 Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPRR2G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR2G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21-q22SPRR2G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M153122: view genomic region
(about GC identifiers)
Start:
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153,122,058 bp from pter |
End:
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153,123,427 bp from pter |
Size:
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1,370 bases |
Orientation:
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minus strand |
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Proteins
for SPRR2G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPR2G_HUMAN, Q9BYE4 (See
protein sequence)Recommended Name: Small proline-rich protein 2G Size: 73 amino acids; 8158 Da
Subcellular location: Cytoplasm (By similarity)Explore the universe of human proteins at neXtProt for SPRR2G: NX_Q9BYE4
SPRR2G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001014313.1
ENSEMBL proteins: ENSP00000357737
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPRR2G for ontologies About GeneDecksing
SPRR2G Antibody Products:
Assay Products for SPRR2G: |
Protein
Domains /
Families
for SPRR2G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPRR2G for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BYE4ProtoNet protein and cluster: Q9BYE4 UniProtKB/Swiss-Prot: SPR2G_HUMAN, Q9BYE4Similarity: Belongs to the cornifin (SPRR) family |
Function
for SPRR2G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPR2G_HUMAN, Q9BYE4Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membrane (By similarity)Induction: During squamous differentiation of epidermal keratinocytes (By similarity) Genatlas biochemistry entry for SPRR2G:small proline rich protein 2G,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiationcomplex (EDC)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2G
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2G
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SPRR2G | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2G |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR2G |
|
Pathways & Interactions
for SPRR2G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRR2G
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SPRR2G (ENSP000003577374) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SPRR2G for ontologies About GeneDecksing
|
Drugs & Compounds
for SPRR2G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPRR2G
Search CenterWatch for drugs/clinical trials and news about SPRR2G / SPR2G
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Transcripts
for SPRR2G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPRR2G gene: NM_001014291.3 Unigene Cluster for SPRR2G: Small proline-rich protein 2G Hs.490253 [show with all ESTs]Unigene Representative Sequence: BG2008441 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000368748(uc009wod.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2G
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2G
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPRR2G (NM_001014291) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR2G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2G |
Additional cDNA sequence: BC130455.1 BC133041.1 2 DOTS entries: DT.203467 DT.91971948
GeneLoc Exon Structure
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Expression
for SPRR2G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPRR2G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCAAGCCCA
About this image
See SPRR2G Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRR2G
SOURCE GeneReport for Unigene cluster: Hs.490253
SABiosciences Custom PCR Arrays for SPRR2G
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPRR2G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR2G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR2G | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR2G |
Orthologs
for SPRR2G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SPRR2G (if available)
TreeFam Gene Tree for SPRR2G (if available) |
Paralogs
for SPRR2G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPRR2G gene
- SPRR1B2 SPRR42 SPRR2F2 SPRR2B2 SPRR2D2 SPRR1A2 SPRR2A2 SPRR2E2
- LELP12 SPRR32
SPRR2G for paralogs About GeneDecksing
|
Genomic Variants
for SPRR2G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPRR2G (153122058 - 153123427 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPRR2G: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR2G |
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Disorders
/ Diseases
for SPRR2G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPRR2G for disorders About GeneDecksing
2  diseases for SPRR2G: About MalaCardschronic interstitial cystitis psoriasis
2 diseases from the University of Copenhagen DISEASES database for SPRR2G:Interstitial cystitis Chronic interstitial cystitis Export disorders for SPRR2G gene to outside databases
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Publications
for SPRR2G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPRR2G gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPRR2G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PubMed id 11279051)1, 2, 3 Cabral A....Backendorf C. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PubMed id 8325635)1, 3 Gibbs S.... Backendorf C. (1993)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PubMed id 18643845)1 Kainu K....Saarialho-Kere U. (2009)
- Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus. (PubMed id 15232223)1 Hong S.H....Kim M.K. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues. (PubMed id 9888996)1 Song H.J....Kartasova T. (1999)
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External Searches for SPRR2G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPRR2G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPRR2G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPRR2G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPRR2G | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPRR2G gene:
Search GeneIP for patents involving SPRR2G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPRR2G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPRR2G | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRR2G | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for SPRR2G | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPRR2G | | OriGene 3'-UTR Clone for SPRR2G | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2G | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2G | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPRR2G | | OriGene Custom Protein Services for SPRR2G | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRR2G | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR2G | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR2G | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR2G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR2G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR2G |
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| | | | Search Tocris compounds for SPRR2G |
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 | | | SPRR2G Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR2G |
|  |  |  | | | | Search ThermoFisher Antibodies for SPRR2G |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2G |
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