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Aliases for SPRR2G Gene

Aliases for SPRR2G Gene

  • Small Proline-Rich Protein 2G 2 3
  • SPR-2G 3 4

External Ids for SPRR2G Gene

Previous GeneCards Identifiers for SPRR2G Gene

  • GC01U990161
  • GC01M151379
  • GC01M151390
  • GC01M124485

Summaries for SPRR2G Gene

GeneCards Summary for SPRR2G Gene

SPRR2G (Small Proline-Rich Protein 2G) is a Protein Coding gene. Diseases associated with SPRR2G include cystitis.

UniProtKB/Swiss-Prot for SPRR2G Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2G Gene

Genomics for SPRR2G Gene

Regulatory Elements for SPRR2G Gene

Genomic Location for SPRR2G Gene

153,149,582 bp from pter
153,150,951 bp from pter
1,370 bases
Minus strand

Genomic View for SPRR2G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR2G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2G Gene

Proteins for SPRR2G Gene

  • Protein details for SPRR2G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Small proline-rich protein 2G
    Protein Accession:
    Secondary Accessions:

    Protein attributes for SPRR2G Gene

    73 amino acids
    Molecular mass:
    8158 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2G Gene

Proteomics data for SPRR2G Gene at MOPED

Post-translational modifications for SPRR2G Gene

No Post-translational modifications

Other Protein References for SPRR2G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR2G Gene

Domains for SPRR2G Gene

Protein Domains for SPRR2G Gene


Suggested Antigen Peptide Sequences for SPRR2G Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BYE4
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR2G: view

No data available for Gene Families for SPRR2G Gene

Function for SPRR2G Gene

Molecular function for SPRR2G Gene

GENATLAS Biochemistry: small proline rich protein 2G,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
UniProtKB/Swiss-Prot Induction: During squamous differentiation of epidermal keratinocytes.

Animal Model Products

CRISPR Products

miRNA for SPRR2G Gene

miRTarBase miRNAs that target SPRR2G

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPRR2G Gene

Localization for SPRR2G Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2G Gene


Subcellular locations from

Jensen Localization Image for SPRR2G Gene COMPARTMENTS Subcellular localization image for SPRR2G gene
Compartment Confidence
cytoskeleton 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SPRR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope NAS 8325635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPRR2G: view

Pathways for SPRR2G Gene

SuperPathways for SPRR2G Gene

No Data Available

Interacting Proteins for SPRR2G Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357737 for SPRR2G Gene via STRING

Gene Ontology (GO) - Biological Process for SPRR2G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0030216 keratinocyte differentiation NAS 8325635
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with SPRR2G: view

No data available for Pathways by source for SPRR2G Gene

Transcripts for SPRR2G Gene

mRNA/cDNA for SPRR2G Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR2G Gene

Small proline-rich protein 2G:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR2G

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2G Gene

No ASD Table

Relevant External Links for SPRR2G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRR2G Gene

mRNA expression in normal human tissues for SPRR2G Gene

mRNA differential expression in normal tissues according to GTEx for SPRR2G Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (39.7) and Skin - Not Sun Exposed (Suprapubic) (10.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRR2G Gene

SOURCE GeneReport for Unigene cluster for SPRR2G Gene Hs.490253

genes like me logo Genes that share expressions with SPRR2G: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPRR2G Gene

Orthologs for SPRR2G Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPRR2G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRR2G 36
  • 99 (a)
Species with no ortholog for SPRR2G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR2G Gene

Gene Tree for SPRR2G (if available)
Gene Tree for SPRR2G (if available)

Paralogs for SPRR2G Gene

No data available for Paralogs for SPRR2G Gene

Variants for SPRR2G Gene

Sequence variations from dbSNP and Humsavar for SPRR2G Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs488552 -- 153,152,574(+) AACAA(C/T)ATGAG upstream-variant-2KB
rs509194 -- 153,149,695(-) GATCA(C/T)TGCCT utr-variant-3-prime
rs510277 -- 153,149,834(-) TCTTA(C/T)TCCCA utr-variant-3-prime
rs513555 -- 153,150,144(+) ATACA(C/T)ACGAA intron-variant
rs516280 -- 153,150,454(-) TAAGA(G/T)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRR2G Gene

Variant ID Type Subtype PubMed ID
nsv2921 CNV Insertion 18451855

Relevant External Links for SPRR2G Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR2G Gene

Disorders for SPRR2G Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SPRR2G Gene including...

Search for SPRR2G Gene in MalaCards »

(1) University of Copenhagen DISEASES for SPRR2G Gene

genes like me logo Genes that share disorders with SPRR2G: view

No data available for UniProtKB/Swiss-Prot for SPRR2G Gene

Publications for SPRR2G Gene

  1. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 2 3 4
  2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PMID: 18643845) Kainu K. … Saarialho-Kere U. (Exp. Dermatol. 2009) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for SPRR2G Gene

Sources for SPRR2G Gene

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