SPRR2F Gene
protein-coding GIFtS: 34
GCID: GC01M153084
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small proline-rich protein 2F
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Aliases
for SPRR2F gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Small Proline-Rich Protein 2F1 2 | | SPR-2F2 3 |
Export aliases for SPRR2F gene to outside databasesPrevious GC identifers: GC01U990160 GC01M149828 GC01M151280 GC01M151351 GC01M124447 |
Summaries
for SPRR2F gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPR2F_HUMAN, Q96RM1Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membrane (By similarity)
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Genomic Views
for SPRR2F gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPRR2F gene promoter:
TBP Zic1 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPRR2F
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR2F |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21-q22SPRR2F Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M153084: view genomic region
(about GC identifiers)
Start:
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153,084,590 bp from pter |
End:
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153,085,991 bp from pter |
Size:
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1,402 bases |
Orientation:
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minus strand |
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Proteins
for SPRR2F gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPR2F_HUMAN, Q96RM1 (See
protein sequence)Recommended Name: Small proline-rich protein 2F Size: 72 amino acids; 7805 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q5T9T3Explore the universe of human proteins at neXtProt for SPRR2F: NX_Q96RM1
SPRR2F Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001014450.1
ENSEMBL proteins: ENSP00000418193
Human Recombinant Protein Products for SPRR2F:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPRR2F for ontologies About GeneDecksing
SPRR2F Antibody Products:
Assay Products for SPRR2F: |
Protein
Domains /
Families
for SPRR2F gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPRR2F for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96RM1ProtoNet protein and cluster: Q96RM1 UniProtKB/Swiss-Prot: SPR2F_HUMAN, Q96RM1Similarity: Belongs to the cornifin (SPRR) family |
Function
for SPRR2F gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: SPR2F_HUMAN, Q96RM1Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membrane (By similarity)Induction: During squamous differentiation of epidermal keratinocytes (By similarity) Genatlas biochemistry entry for SPRR2F:small proline rich protein 2F,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiationcomplex (EDC)
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2F (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2F
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPRR2F (NM_001014450) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR2F | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2F |
|
Pathways & Interactions
for SPRR2F gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRR2F
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SPRR2F for ontologies About GeneDecksing
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Drugs & Compounds
for SPRR2F gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPRR2F
Search CenterWatch for drugs/clinical trials and news about SPRR2F / SPR2F
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Transcripts
for SPRR2F gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPRR2F gene: NM_001014450.1 Unigene Cluster for SPRR2F: Small proline-rich protein 2F Hs.490252 [show with all ESTs]Unigene Representative Sequence: NM_0010144501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000468739(uc001fbi.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2F (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2F
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPRR2F (NM_001014450) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR2F | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2F |
3 DOTS entries: DT.95375948 DT.91674741 DT.86839990
GeneLoc Exon Structure
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Expression
for SPRR2F gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPRR2F expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTTCCACC
About this image
See SPRR2F Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.490252
SABiosciences Custom PCR Arrays for SPRR2F
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPRR2F | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR2F | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR2F |
Orthologs
for SPRR2F gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for SPRR2F (if available)
TreeFam Gene Tree for SPRR2F (if available) |
Paralogs
for SPRR2F gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPRR2F gene
- SPRR1B2 SPRR42 SPRR2B2 SPRR2D2 SPRR2G2 SPRR1A2 SPRR2A2 SPRR2E2
- LELP12 SPRR32
SPRR2F for paralogs About GeneDecksing
|
Genomic Variants
for SPRR2F gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPRR2F (153084590 - 153085991 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPRR2F
1 CNV: 64986 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR2F |
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Disorders
/ Diseases
for SPRR2F gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPRR2F for disorders About GeneDecksing
1  disease for SPRR2F: About MalaCardspsoriasis
Export disorders for SPRR2F gene to outside databases
|
Publications
for SPRR2F gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPRR2F gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPRR2F) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PubMed id 11279051)1, 2, 3 Cabral A....Backendorf C. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PubMed id 8325635)1, 3 Gibbs S.... Backendorf C. (1993)
- Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PubMed id 18643845)1 Kainu K....Saarialho-Kere U. (2009)
- Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus. (PubMed id 15232223)1 Hong S.H....Kim M.K. (2004)
- Mouse Sprr2 genes: a clustered family of genes showing differential expression in epithelial tissues. (PubMed id 9888996)1 Song H.J....Kartasova T. (1999)
- Secretion of disulfide-linked human T-cell receptor gamma delta heterodimers. (PubMed id 8340374)1 Davodeau F....Jacques Y. (1993)
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External Searches for SPRR2F gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPRR2F gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPRR2F gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPRR2F gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPRR2F | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SPRR2F gene:
Search GeneIP for patents involving SPRR2F
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPRR2F gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPRR2F | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRR2F | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for SPRR2F | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPRR2F | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2F | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2F | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPRR2F | | OriGene Custom Protein Services for SPRR2F | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRR2F | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR2F | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR2F | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR2F | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR2F | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR2F |
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| | | | Search Tocris compounds for SPRR2F |
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 | | | SPRR2F Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for SPRR2F |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2F |
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