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Aliases for SPRR2F Gene

Aliases for SPRR2F Gene

  • Small Proline-Rich Protein 2F 2 3
  • SPR-2F 3 4

External Ids for SPRR2F Gene

Summaries for SPRR2F Gene

GeneCards Summary for SPRR2F Gene

SPRR2F (Small Proline-Rich Protein 2F) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPRR2F Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2F Gene

Genomics for SPRR2F Gene

Genomic Location for SPRR2F Gene

Start:
153,112,114 bp from pter
End:
153,113,515 bp from pter
Size:
1,402 bases
Orientation:
Minus strand

Genomic View for SPRR2F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2F Gene

Regulatory Elements for SPRR2F Gene

Transcription factor binding sites by QIAGEN in the SPRR2F gene promoter:

Proteins for SPRR2F Gene

  • Protein details for SPRR2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RM1-SPR2F_HUMAN
    Recommended name:
    Small proline-rich protein 2F
    Protein Accession:
    Q96RM1
    Secondary Accessions:
    • Q5T9T3

    Protein attributes for SPRR2F Gene

    Size:
    72 amino acids
    Molecular mass:
    7805 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2F Gene

Proteomics data for SPRR2F Gene at MOPED

Post-translational modifications for SPRR2F Gene

No Post-translational modifications

Other Protein References for SPRR2F Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR2F Gene

Domains for SPRR2F Gene

Protein Domains for SPRR2F Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SPR2F_HUMAN
Family:
  • Belongs to the cornifin (SPRR) family.:
    • Q96RM1
genes like me logo Genes that share domains with SPRR2F: view

No data available for Gene Families for SPRR2F Gene

Function for SPRR2F Gene

Molecular function for SPRR2F Gene

GENATLAS Biochemistry: small proline rich protein 2F,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity).
UniProtKB/Swiss-Prot Induction: During squamous differentiation of epidermal keratinocytes.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPRR2F Gene

Localization for SPRR2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2F Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR2F Gene COMPARTMENTS Subcellular localization image for SPRR2F gene
Compartment Confidence
cytoskeleton 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SPRR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope NAS 8325635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPRR2F: view

Pathways for SPRR2F Gene

SuperPathways for SPRR2F Gene

No Data Available

Interacting Proteins for SPRR2F Gene

Gene Ontology (GO) - Biological Process for SPRR2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0030216 keratinocyte differentiation NAS 8325635
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with SPRR2F: view

No data available for Pathways by source for SPRR2F Gene

Transcripts for SPRR2F Gene

mRNA/cDNA for SPRR2F Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR2F Gene

Small proline-rich protein 2F:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2F Gene

No ASD Table

Relevant External Links for SPRR2F Gene

GeneLoc Exon Structure for
SPRR2F
ECgene alternative splicing isoforms for
SPRR2F

Expression for SPRR2F Gene

mRNA expression in normal human tissues for SPRR2F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRR2F Gene

This gene is overexpressed in Esophagus - Mucosa (21.9), Minor Salivary Gland (17.9), and Ovary (9.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPRR2F Gene

SOURCE GeneReport for Unigene cluster for SPRR2F Gene Hs.490252

genes like me logo Genes that share expressions with SPRR2F: view

Orthologs for SPRR2F Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SPRR2F Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sprr2k 16
Species with no ortholog for SPRR2F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR2F Gene

ENSEMBL:
Gene Tree for SPRR2F (if available)
TreeFam:
Gene Tree for SPRR2F (if available)

Paralogs for SPRR2F Gene

No data available for Paralogs for SPRR2F Gene

Variants for SPRR2F Gene

Sequence variations from dbSNP and Humsavar for SPRR2F Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs366912 -- 153,114,476(-) ATTGT(G/T)CTCTA upstream-variant-2KB
rs383582 -- 153,111,770(-) TATTC(A/G)CAGCA downstream-variant-500B
rs1392805 -- 153,111,962(+) attaa(A/G)gaaaa downstream-variant-500B
rs1500941 -- 153,115,185(+) ACCTT(A/G)AGGCC upstream-variant-2KB
rs10157591 -- 153,114,067(+) CCCTG(G/T)GATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRR2F Gene

Variant ID Type Subtype PubMed ID
nsv464017 CNV Loss 19166990
esv22397 CNV Gain 19812545

Relevant External Links for SPRR2F Gene

HapMap Linkage Disequilibrium report
SPRR2F

Disorders for SPRR2F Gene

No disorders were found for SPRR2F Gene.

No data available for UniProtKB/Swiss-Prot for SPRR2F Gene

Publications for SPRR2F Gene

  1. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 2 3 4
  2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PMID: 18643845) Kainu K. … Saarialho-Kere U. (Exp. Dermatol. 2009) 3
  5. Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. (PMID: 23383108) Denner J. … AkyA1z L. (PLoS ONE 2013) 3

Products for SPRR2F Gene

Sources for SPRR2F Gene

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