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Aliases for SPRR2E Gene

Aliases for SPRR2E Gene

  • Small Proline-Rich Protein 2E 2 3
  • Small Proline-Rich Protein II 3 4
  • SPR-II 3 4
  • SPR-2E 3 4

External Ids for SPRR2E Gene

Summaries for SPRR2E Gene

Entrez Gene Summary for SPRR2E Gene

  • This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]

GeneCards Summary for SPRR2E Gene

SPRR2E (Small Proline-Rich Protein 2E) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SPRR2D.

UniProtKB/Swiss-Prot for SPRR2E Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2E Gene

Genomics for SPRR2E Gene

Genomic Location for SPRR2E Gene

Start:
153,093,135 bp from pter
End:
153,106,184 bp from pter
Size:
13,050 bases
Orientation:
Minus strand

Genomic View for SPRR2E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2E Gene

Regulatory Elements for SPRR2E Gene

Proteins for SPRR2E Gene

  • Protein details for SPRR2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22531-SPR2E_HUMAN
    Recommended name:
    Small proline-rich protein 2E
    Protein Accession:
    P22531
    Secondary Accessions:
    • Q5T9T4
    • Q96RM2

    Protein attributes for SPRR2E Gene

    Size:
    72 amino acids
    Molecular mass:
    7855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2E Gene

Proteomics data for SPRR2E Gene at MOPED

Post-translational modifications for SPRR2E Gene

No Post-translational modifications

Other Protein References for SPRR2E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR2E Gene

Domains for SPRR2E Gene

Protein Domains for SPRR2E Gene

Suggested Antigen Peptide Sequences for SPRR2E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22531

UniProtKB/Swiss-Prot:

SPR2E_HUMAN
Family:
  • Belongs to the cornifin (SPRR) family.:
    • P22531
genes like me logo Genes that share domains with SPRR2E: view

No data available for Gene Families for SPRR2E Gene

Function for SPRR2E Gene

Molecular function for SPRR2E Gene

GENATLAS Biochemistry: small proline rich protein 2E,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane
UniProtKB/Swiss-Prot Induction: During squamous differentiation of epidermal keratinocytes

Gene Ontology (GO) - Molecular Function for SPRR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 3133554
GO:0005515 protein binding IPI 9722562
genes like me logo Genes that share ontologies with SPRR2E: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPRR2E Gene

Localization for SPRR2E Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2E Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR2E Gene COMPARTMENTS Subcellular localization image for SPRR2E gene
Compartment Confidence
cytoskeleton 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SPRR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IEA --
GO:0005737 cytoplasm IDA 3133554
genes like me logo Genes that share ontologies with SPRR2E: view

Pathways for SPRR2E Gene

SuperPathways for SPRR2E Gene

No Data Available

Interacting Proteins for SPRR2E Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357739%0d%0a9606.ENSP00000378201%0d%0a9606.ENSP00000354884%0d%0a9606.ENSP00000368684%0d%0a
Selected Interacting proteins: ENSP00000357739 for SPRR2E Gene via STRING

Gene Ontology (GO) - Biological Process for SPRR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with SPRR2E: view

No data available for Pathways by source for SPRR2E Gene

Transcripts for SPRR2E Gene

mRNA/cDNA for SPRR2E Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR2E Gene

Small proline-rich protein 2E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2E Gene

No ASD Table

Relevant External Links for SPRR2E Gene

GeneLoc Exon Structure for
SPRR2E
ECgene alternative splicing isoforms for
SPRR2E

Expression for SPRR2E Gene

mRNA expression in normal human tissues for SPRR2E Gene

mRNA differential expression in normal tissues according to GTEx for SPRR2E Gene

This gene is overexpressed in Esophagus - Mucosa (21.4), Skin - Sun Exposed (Lower leg) (12.0), Skin - Not Sun Exposed (Suprapubic) (5.9), Minor Salivary Gland (5.3), and Cervix - Ectocervix (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRR2E Gene

SOURCE GeneReport for Unigene cluster for SPRR2E Gene Hs.568518

genes like me logo Genes that share expressions with SPRR2E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPRR2E Gene

Orthologs for SPRR2E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPRR2E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRR2E 36
  • 100 (a)
OneToOne
Species with no ortholog for SPRR2E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR2E Gene

ENSEMBL:
Gene Tree for SPRR2E (if available)
TreeFam:
Gene Tree for SPRR2E (if available)

Paralogs for SPRR2E Gene

Paralogs for SPRR2E Gene

genes like me logo Genes that share paralogs with SPRR2E: view

Variants for SPRR2E Gene

Sequence variations from dbSNP and Humsavar for SPRR2E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs628724 -- 153,095,731(+) TCTGT(C/T)CATTT upstream-variant-2KB
rs1933388 -- 153,093,786(+) TGATA(C/T)GACAG intron-variant
rs3737865 -- 153,093,596(+) CATTT(C/T)TGCTG reference, synonymous-codon
rs3843257 -- 153,092,811(-) ATAAT(G/T)AGCTG downstream-variant-500B
rs3843258 -- 153,094,549(+) AACCT(C/T)TTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRR2E Gene

Variant ID Type Subtype PubMed ID
nsv464017 CNV Loss 19166990
esv2718239 CNV Deletion 23290073

Relevant External Links for SPRR2E Gene

HapMap Linkage Disequilibrium report
SPRR2E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR2E Gene

Disorders for SPRR2E Gene

No disorders were found for SPRR2E Gene.

No data available for UniProtKB/Swiss-Prot for SPRR2E Gene

Publications for SPRR2E Gene

  1. Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes. (PMID: 3133554) Kartasova T. … van de Putte P. (Mol. Cell. Biol. 1988) 3 4
  2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3
  3. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PMID: 18643845) Kainu K. … Saarialho-Kere U. (Exp. Dermatol. 2009) 3

Products for SPRR2E Gene

Sources for SPRR2E Gene

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