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Aliases for SPRR2E Gene

Aliases for SPRR2E Gene

  • Small Proline Rich Protein 2E 2 3
  • Small Proline-Rich Protein II 3 4
  • Small Proline-Rich Protein 2E 2 5
  • SPR-II 3 4
  • SPR-2E 3 4

External Ids for SPRR2E Gene

Previous GeneCards Identifiers for SPRR2E Gene

  • GC01U990159
  • GC01M149827
  • GC01M151333
  • GC01M151337
  • GC01M124428

Summaries for SPRR2E Gene

Entrez Gene Summary for SPRR2E Gene

  • This gene encodes a member of a family of small proline-rich proteins clustered in the epidermal differentiation complex on chromosome 1q21. The encoded protein, along with other family members, is a component of the cornified cell envelope that forms beneath the plasma membrane in terminally differentiated stratified squamous epithelia. This envelope serves as a barrier against extracellular and environmental factors. The seven SPRR2 genes (A-G) appear to have been homogenized by gene conversion compared to others in the cluster that exhibit greater differences in protein structure. [provided by RefSeq, Feb 2014]

GeneCards Summary for SPRR2E Gene

SPRR2E (Small Proline Rich Protein 2E) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SPRR2B.

UniProtKB/Swiss-Prot for SPRR2E Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2E Gene

Genomics for SPRR2E Gene

Regulatory Elements for SPRR2E Gene

Enhancers for SPRR2E Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPRR2E on UCSC Golden Path with GeneCards custom track

Genomic Location for SPRR2E Gene

Chromosome:
1
Start:
153,093,135 bp from pter
End:
153,106,184 bp from pter
Size:
13,050 bases
Orientation:
Minus strand

Genomic View for SPRR2E Gene

Genes around SPRR2E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRR2E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRR2E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2E Gene

Proteins for SPRR2E Gene

  • Protein details for SPRR2E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22531-SPR2E_HUMAN
    Recommended name:
    Small proline-rich protein 2E
    Protein Accession:
    P22531
    Secondary Accessions:
    • Q5T9T4
    • Q96RM2

    Protein attributes for SPRR2E Gene

    Size:
    72 amino acids
    Molecular mass:
    7855 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2E Gene

Proteomics data for SPRR2E Gene at MOPED

Post-translational modifications for SPRR2E Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRR2E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR2E Gene

Domains & Families for SPRR2E Gene

Protein Domains for SPRR2E Gene

Suggested Antigen Peptide Sequences for SPRR2E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22531

UniProtKB/Swiss-Prot:

SPR2E_HUMAN :
  • Belongs to the cornifin (SPRR) family.
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR2E: view

No data available for Gene Families for SPRR2E Gene

Function for SPRR2E Gene

Molecular function for SPRR2E Gene

GENATLAS Biochemistry:
small proline rich protein 2E,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
UniProtKB/Swiss-Prot Induction:
During squamous differentiation of epidermal keratinocytes.

Gene Ontology (GO) - Molecular Function for SPRR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity TAS 3133554
genes like me logo Genes that share ontologies with SPRR2E: view

Phenotypes for SPRR2E Gene

GenomeRNAi human phenotypes for SPRR2E:
genes like me logo Genes that share phenotypes with SPRR2E: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRR2E Gene

Localization for SPRR2E Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2E Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR2E Gene COMPARTMENTS Subcellular localization image for SPRR2E gene
Compartment Confidence
plasma membrane 3
cytosol 2
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for SPRR2E Gene

Pathways & Interactions for SPRR2E Gene

SuperPathways for SPRR2E Gene

No Data Available

Interacting Proteins for SPRR2E Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357739%0d%0a9606.ENSP00000378201%0d%0a9606.ENSP00000368684%0d%0a9606.ENSP00000354884%0d%0a
Selected Interacting proteins: ENSP00000357739 for SPRR2E Gene via STRING

Gene Ontology (GO) - Biological Process for SPRR2E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0018149 peptide cross-linking IBA --
genes like me logo Genes that share ontologies with SPRR2E: view

No data available for Pathways by source and SIGNOR curated interactions for SPRR2E Gene

Drugs & Compounds for SPRR2E Gene

No Compound Related Data Available

Transcripts for SPRR2E Gene

mRNA/cDNA for SPRR2E Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR2E Gene

Small proline-rich protein 2E:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2E Gene

No ASD Table

Relevant External Links for SPRR2E Gene

GeneLoc Exon Structure for
SPRR2E
ECgene alternative splicing isoforms for
SPRR2E

Expression for SPRR2E Gene

mRNA expression in normal human tissues for SPRR2E Gene

mRNA differential expression in normal tissues according to GTEx for SPRR2E Gene

This gene is overexpressed in Esophagus - Mucosa (x21.4), Skin - Sun Exposed (Lower leg) (x12.0), Skin - Not Sun Exposed (Suprapubic) (x5.9), Minor Salivary Gland (x5.3), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for SPRR2E Gene

This gene is overexpressed in Cervix (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRR2E Gene



SOURCE GeneReport for Unigene cluster for SPRR2E Gene Hs.568518

genes like me logo Genes that share expression patterns with SPRR2E: view

Protein tissue co-expression partners for SPRR2E Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPRR2E Gene

Orthologs for SPRR2E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPRR2E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRR2E 36
  • 100 (a)
OneToOne
Species with no ortholog for SPRR2E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR2E Gene

ENSEMBL:
Gene Tree for SPRR2E (if available)
TreeFam:
Gene Tree for SPRR2E (if available)

Paralogs for SPRR2E Gene

Paralogs for SPRR2E Gene

genes like me logo Genes that share paralogs with SPRR2E: view

Variants for SPRR2E Gene

Sequence variations from dbSNP and Humsavar for SPRR2E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs628724 -- 153,095,731(+) TCTGT(C/T)CATTT upstream-variant-2KB
rs1933388 -- 153,093,786(+) TGATA(A/C/T)GACAG intron-variant
rs3737865 -- 153,093,596(+) CATTT(C/T)TGCTG reference, synonymous-codon
rs3843257 -- 153,092,811(-) ATAAT(G/T)AGCTG downstream-variant-500B
rs3843258 -- 153,094,549(+) AACCT(C/T)TTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRR2E Gene

Variant ID Type Subtype PubMed ID
nsv464017 CNV Loss 19166990
esv2718239 CNV Deletion 23290073

Variation tolerance for SPRR2E Gene

Residual Variation Intolerance Score: 77.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRR2E Gene

HapMap Linkage Disequilibrium report
SPRR2E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR2E Gene

Disorders for SPRR2E Gene

Relevant External Links for SPRR2E

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRR2E

No disorders were found for SPRR2E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR2E Gene

Publications for SPRR2E Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3
  3. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. (PMID: 24657165) Kim H. … D'Andrea A.D. (Mol. Cell 2014) 3
  4. Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1. (PMID: 24366813) Hauri S. … Gstaiger M. (Mol. Syst. Biol. 2013) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for SPRR2E Gene

Sources for SPRR2E Gene

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