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Aliases for SPRR2D Gene

Aliases for SPRR2D Gene

  • Small Proline Rich Protein 2D 2 3
  • Small Proline-Rich Protein 2D 2 5
  • Small Proline-Rich Protein II 3 4
  • SPR-2D 3 4
  • SPR-II 3 4

External Ids for SPRR2D Gene

Previous GeneCards Identifiers for SPRR2D Gene

  • GC01U990158
  • GC01M149826
  • GC01M151279
  • GC01M151281
  • GC01M124375

Summaries for SPRR2D Gene

GeneCards Summary for SPRR2D Gene

SPRR2D (Small Proline Rich Protein 2D) is a Protein Coding gene. An important paralog of this gene is SPRR2B.

UniProtKB/Swiss-Prot for SPRR2D Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2D Gene

Genomics for SPRR2D Gene

Regulatory Elements for SPRR2D Gene

Genomic Location for SPRR2D Gene

Chromosome:
1
Start:
153,039,725 bp from pter
End:
153,041,931 bp from pter
Size:
2,207 bases
Orientation:
Minus strand

Genomic View for SPRR2D Gene

Genes around SPRR2D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRR2D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRR2D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2D Gene

Proteins for SPRR2D Gene

  • Protein details for SPRR2D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22532-SPR2D_HUMAN
    Recommended name:
    Small proline-rich protein 2D
    Protein Accession:
    P22532
    Secondary Accessions:
    • A4QN03
    • A8K5K2
    • D3DV33
    • Q5T523
    • Q96RM3

    Protein attributes for SPRR2D Gene

    Size:
    72 amino acids
    Molecular mass:
    7905 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2D Gene

Proteomics data for SPRR2D Gene at MOPED

Post-translational modifications for SPRR2D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRR2D Gene

No data available for DME Specific Peptides for SPRR2D Gene

Domains & Families for SPRR2D Gene

Protein Domains for SPRR2D Gene

Suggested Antigen Peptide Sequences for SPRR2D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22532

UniProtKB/Swiss-Prot:

SPR2D_HUMAN :
  • Belongs to the cornifin (SPRR) family.
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR2D: view

No data available for Gene Families for SPRR2D Gene

Function for SPRR2D Gene

Molecular function for SPRR2D Gene

GENATLAS Biochemistry:
small proline rich protein 2D,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
UniProtKB/Swiss-Prot Induction:
During squamous differentiation of epidermal keratinocytes.

Phenotypes for SPRR2D Gene

GenomeRNAi human phenotypes for SPRR2D:
genes like me logo Genes that share phenotypes with SPRR2D: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRR2D Gene

Localization for SPRR2D Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR2D Gene COMPARTMENTS Subcellular localization image for SPRR2D gene
Compartment Confidence
plasma membrane 3
cytosol 2
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for SPRR2D Gene

Pathways & Interactions for SPRR2D Gene

SuperPathways for SPRR2D Gene

No Data Available

Interacting Proteins for SPRR2D Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000353542%0d%0a9606.ENSP00000343325%0d%0a9606.ENSP00000278568%0d%0a
Selected Interacting proteins: P22532-SPR2D_HUMAN ENSP00000353542 for SPRR2D Gene via I2D STRING MINT

Gene Ontology (GO) - Biological Process for SPRR2D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0018149 peptide cross-linking IBA --
genes like me logo Genes that share ontologies with SPRR2D: view

No data available for Pathways by source and SIGNOR curated interactions for SPRR2D Gene

Drugs & Compounds for SPRR2D Gene

No Compound Related Data Available

Transcripts for SPRR2D Gene

mRNA/cDNA for SPRR2D Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR2D Gene

Small proline-rich protein 2D:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2D Gene

No ASD Table

Relevant External Links for SPRR2D Gene

GeneLoc Exon Structure for
SPRR2D
ECgene alternative splicing isoforms for
SPRR2D

Expression for SPRR2D Gene

mRNA expression in normal human tissues for SPRR2D Gene

mRNA differential expression in normal tissues according to GTEx for SPRR2D Gene

This gene is overexpressed in Esophagus - Mucosa (x28.1), Minor Salivary Gland (x10.6), Cervix - Ectocervix (x5.5), and Vagina (x5.1).

Protein differential expression in normal tissues from HIPED for SPRR2D Gene

This gene is overexpressed in Cervix (40.8), Oral epithelium (12.4), and Esophagus (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRR2D Gene



SOURCE GeneReport for Unigene cluster for SPRR2D Gene Hs.505327

genes like me logo Genes that share expression patterns with SPRR2D: view

Protein tissue co-expression partners for SPRR2D Gene

- Elite partner

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPRR2D Gene

Orthologs for SPRR2D Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPRR2D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRR2D 36
  • 100 (a)
OneToOne
Species with no ortholog for SPRR2D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR2D Gene

ENSEMBL:
Gene Tree for SPRR2D (if available)
TreeFam:
Gene Tree for SPRR2D (if available)

Paralogs for SPRR2D Gene

Paralogs for SPRR2D Gene

genes like me logo Genes that share paralogs with SPRR2D: view

Variants for SPRR2D Gene

Sequence variations from dbSNP and Humsavar for SPRR2D Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1846857 - 153,040,289(+) TGGCG(C/T)GGGGC reference, missense
rs426360 -- 153,042,234(+) TCTTC(C/T)TTTGT upstream-variant-2KB
rs546666 -- 153,042,909(+) TGTCT(A/G)ATTTC upstream-variant-2KB
rs679378 -- 153,039,240(+) AACAC(A/G)GCTGC downstream-variant-500B
rs1140232 -- 153,039,989(-) CTGCC(A/C/G/T)GTGAT utr-variant-3-prime

Variation tolerance for SPRR2D Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRR2D Gene

HapMap Linkage Disequilibrium report
SPRR2D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPRR2D Gene

Disorders for SPRR2D Gene

Relevant External Links for SPRR2D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRR2D

No disorders were found for SPRR2D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR2D Gene

Publications for SPRR2D Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3
  3. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3
  5. Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PMID: 18643845) Kainu K. … Saarialho-Kere U. (Exp. Dermatol. 2009) 3

Products for SPRR2D Gene

Sources for SPRR2D Gene

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