Aliases for SPRR2B Gene
Aliases for SPRR2B Gene
External Ids for SPRR2B Gene
- HGNC: 11262
- Entrez Gene: 6701
- Ensembl: ENSG00000196805
- OMIM: 182268
- UniProtKB: P35325
Previous GeneCards Identifiers for SPRR2B Gene
- GC01M150859
- GC01M148825
- GC01M149818
- GC01M150259
- GC01M149825
- GC01M151278
- GC01M151309
- GC01M124405
Summaries for SPRR2B Gene
GeneCards Summary for SPRR2B Gene
SPRR2B (Small Proline Rich Protein 2B) is a Protein Coding gene. Among its related pathways are Developmental Biology.
UniProtKB/Swiss-Prot for SPRR2B Gene
-
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2B Gene
Genomics for SPRR2B Gene
Regulatory Elements for SPRR2B Gene
Enhancers for SPRR2B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01F153122 | 1.1 | Ensembl ENCODE | 6.9 | -52.0 | -51992 | 2.5 | TBP KLF17 YBX1 FEZF1 ZBTB40 RAD21 GLIS2 SCRT2 FOS ZNF263 | SPRR2C SPRR2G LELP1 SPRR2B SPRR2F |
| GH01F153119 | 0.7 | ENCODE | 6.9 | -48.0 | -47984 | 0.4 | LEF1 PKNOX1 ESRRA RFX1 NR2F1 NR4A1 ZEB2 DPF2 ARID1B NCOR1 | SPRR2G SPRR2B SPRR2F SPRR2C |
| GH01F153099 | 0.8 | ENCODE | 0.3 | -28.6 | -28564 | 2.3 | GTF2F1 HDAC1 ESRRA TAL1 JUN MAX RAD21 FOSL1 NCOR1 SMC3 | SPRR2C SPRR1B SPRR2F SPRR2E SPRR2B |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SPRR2B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for SPRR2B Gene
- Chromosome:
- 1
- Start:
- 153,070,224 bp from pter
- End:
- 153,071,608 bp from pter
- Size:
- 1,385 bases
- Orientation:
- Minus strand
Genomic View for SPRR2B Gene
Genes around SPRR2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
SPRR2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPRR2B Gene
Proteins for SPRR2B Gene
-
Protein details for SPRR2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35325-SPR2B_HUMAN
- Recommended name:
- Small proline-rich protein 2B
- Protein Accession:
- P35325
- Q5T528
Protein attributes for SPRR2B Gene
- Size:
- 72 amino acids
- Molecular mass:
- 7975 Da
- Quaternary structure:
- No Data Available
Protein Expression for SPRR2B Gene
Post-translational modifications for SPRR2B Gene
Other Protein References for SPRR2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for SPRR2B
Protein Products
-
OriGene Purified Proteins for SPRR2B
- Search Origene for MassSpec and Protein Over-expression Lysates for SPRR2B
- Origene Custom Protein Services for SPRR2B
- antibodies-online Proteins for SPRR2B: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SPRR2B
Assay Products
- antibodies-online Kits for SPRR2B: See all 1
No data available for DME Specific Peptides for SPRR2B Gene
Domains & Families for SPRR2B Gene
Gene Families for SPRR2B Gene
Protein Domains for SPRR2B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPRR2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35325- Family:
-
- Belongs to the cornifin (SPRR) family.
Function for SPRR2B Gene
Molecular function for SPRR2B Gene
- GENATLAS Biochemistry:
- small proline rich protein 2B,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
- UniProtKB/Swiss-Prot Function:
- Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
- UniProtKB/Swiss-Prot Induction:
- By UV irradiation and carcinogenic agents. During squamous differentiation of epidermal keratinocytes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IBA | -- |
Phenotypes for SPRR2B Gene
- GenomeRNAi human phenotypes for SPRR2B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPRR2B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPRR2B gene
- Search ViGene Biosciences for SPRR2B
CRISPR Products
-
OriGene CRISPR knockouts for SPRR2B
- GenScript: Design CRISPR guide RNA sequences for SPRR2B
miRNA Products
- Search ViGene Biosciences for SPRR2B
Inhibitory RNA Products
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for SPRR2B
- Browse OriGene Inhibitory RNA Products For SPRR2B
- Search ViGene Biosciences for SPRR2B
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPRR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPRR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SPRR2B
-
ViGene Biosciences adenoviral particle packaged cDNA for SPRR2B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPRR2B gene
- Search ViGene Biosciences for SPRR2B
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRR2B Gene
Localization for SPRR2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPRR2B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | NAS | 8325635 |
| GO:0005737 | cytoplasm | IEA,IBA | -- |
Pathways & Interactions for SPRR2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology | ||
Pathways by source for SPRR2B Gene
1 Reactome pathway for SPRR2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008544 | epidermis development | NAS | 8325635 |
| GO:0018149 | peptide cross-linking | IBA | -- |
| GO:0030216 | keratinocyte differentiation | NAS | 8325635 |
| GO:0031424 | keratinization | IEA | -- |
No data available for SIGNOR curated interactions for SPRR2B Gene
Transcripts for SPRR2B Gene
mRNA/cDNA for SPRR2B Gene
- (2) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (87) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPRR2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPRR2B
- GenScript: Design CRISPR guide RNA sequences for SPRR2B
miRNA Products
- Search ViGene Biosciences for SPRR2B
Inhibitory RNA Products
- Origene shRNA, siRNA, mouse_rna, and RNAi products in human, mouse, rat for SPRR2B
- Browse OriGene Inhibitory RNA Products For SPRR2B
- Search ViGene Biosciences for SPRR2B
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPRR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPRR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for SPRR2B Gene
mRNA differential expression in normal tissues according to GTEx for SPRR2B Gene
This gene is overexpressed in Esophagus - Mucosa (x23.9), Skin - Sun Exposed (Lower leg) (x8.3), Minor Salivary Gland (x7.3), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Cervix - Ectocervix (x4.0).
This gene is overexpressed in Cervix (66.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRR2B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SPRR2B Gene:
SPRR2BSOURCE GeneReport for Unigene cluster for SPRR2B Gene:
Hs.568239mRNA Expression by UniProt/SwissProt for SPRR2B Gene:
P35325-SPR2B_HUMAN
Tissue specificity:
Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SPRR2B Gene
Orthologs for SPRR2B Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPRR2B 35 |
|
OneToOne |
- Species where no ortholog for SPRR2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SPRR2B Gene
No data available for Paralogs for SPRR2B Gene
Variants for SPRR2B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1048268 | -- | ||||
| rs111332534 | -- | 153,071,399(+) | TATAT(-/A)TTTTT | intron-variant | |
| rs111739532 | -- | 153,072,780(+) | CATTT(C/T)AGTAC | upstream-variant-2KB | |
| rs11205181 | -- | 153,073,252(+) | GTCCA(C/T)ATGTC | upstream-variant-2KB | |
| rs11205182 | -- | 153,073,272(+) | GGGTG(C/T)AGTAA | upstream-variant-2KB |
Residual Variation Intolerance Score:
66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SPRR2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPRR2B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR2B Gene
Disorders for SPRR2B Gene
Relevant External Links for SPRR2B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SPRR2B
No disorders were found for SPRR2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR2B Gene
Publications for SPRR2B Gene
- Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3. (PMID: 14748073) Lehr E. … Brown D. (J. Med. Virol. 2004) 3 22 64
- Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 3 4 64
- Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. (PMID: 22374195) Epstein T.G. … Khurana Hershey G.K. (Ann. Allergy Asthma Immunol. 2012) 3 64
Products for SPRR2B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- OriGene Purified Proteins for SPRR2B
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- Origene Custom Protein Services for SPRR2B
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- Browse OriGene Inhibitory RNA Products For SPRR2B
- Browse OriGene qPCR primer pairs and template standards
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search antibodies-online for antibodies
- antibodies-online Kits for SPRR2B: See all 1
- antibodies-online Proteins for SPRR2B: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for SPRR2B
- Search GeneTex for Proteins for SPRR2B
- ViGene Biosciences adenoviral particle packaged cDNA for SPRR2B gene
- ViGene Biosciences lentiviral particle packaged cDNA for SPRR2B gene
- Search ViGene Biosciences for SPRR2B
- Horizon Cell Lines for SPRR2B
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPRR2B
- VectorBuilder custom plasmid, inducible vectors for SPRR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPRR2B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SPRR2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
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- (88) miRTarBase
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- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
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