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Aliases for SPRR2B Gene

Aliases for SPRR2B Gene

  • Small Proline-Rich Protein 2B 2 3
  • SPR-2B 3 4

External Ids for SPRR2B Gene

Previous GeneCards Identifiers for SPRR2B Gene

  • GC01M150859
  • GC01M148825
  • GC01M149818
  • GC01M150259
  • GC01M149825
  • GC01M151278
  • GC01M151309
  • GC01M124405

Summaries for SPRR2B Gene

GeneCards Summary for SPRR2B Gene

SPRR2B (Small Proline-Rich Protein 2B) is a Protein Coding gene. Diseases associated with SPRR2B include oral squamous cell carcinoma. An important paralog of this gene is SPRR2A.

UniProtKB/Swiss-Prot for SPRR2B Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2B Gene

Genomics for SPRR2B Gene

Regulatory Elements for SPRR2B Gene

Genomic Location for SPRR2B Gene

Start:
153,070,224 bp from pter
End:
153,071,608 bp from pter
Size:
1,385 bases
Orientation:
Minus strand

Genomic View for SPRR2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2B Gene

Proteins for SPRR2B Gene

  • Protein details for SPRR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35325-SPR2B_HUMAN
    Recommended name:
    Small proline-rich protein 2B
    Protein Accession:
    P35325
    Secondary Accessions:
    • Q5T528

    Protein attributes for SPRR2B Gene

    Size:
    72 amino acids
    Molecular mass:
    7975 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2B Gene

Proteomics data for SPRR2B Gene at MOPED

Post-translational modifications for SPRR2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRR2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR2B Gene

Domains for SPRR2B Gene

Protein Domains for SPRR2B Gene

Suggested Antigen Peptide Sequences for SPRR2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35325

UniProtKB/Swiss-Prot:

SPR2B_HUMAN :
  • P35325
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR2B: view

No data available for Gene Families for SPRR2B Gene

Function for SPRR2B Gene

Molecular function for SPRR2B Gene

GENATLAS Biochemistry: small proline rich protein 2B,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane
UniProtKB/Swiss-Prot Induction: By UV irradiation and carcinogenic agents. During squamous differentiation of epidermal keratinocytes

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPRR2B Gene

Localization for SPRR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR2B Gene COMPARTMENTS Subcellular localization image for SPRR2B gene
Compartment Confidence
cytoskeleton 5
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SPRR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope NAS 8325635
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPRR2B: view

Pathways for SPRR2B Gene

SuperPathways for SPRR2B Gene

No Data Available

Interacting Proteins for SPRR2B Gene

Gene Ontology (GO) - Biological Process for SPRR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0030216 keratinocyte differentiation NAS 8325635
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with SPRR2B: view

No data available for Pathways by source for SPRR2B Gene

Transcripts for SPRR2B Gene

mRNA/cDNA for SPRR2B Gene

(87) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR2B Gene

Small proline-rich protein 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR2B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2B Gene

No ASD Table

Relevant External Links for SPRR2B Gene

GeneLoc Exon Structure for
SPRR2B
ECgene alternative splicing isoforms for
SPRR2B

Expression for SPRR2B Gene

mRNA expression in normal human tissues for SPRR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRR2B Gene

This gene is overexpressed in Esophagus - Mucosa (23.9), Skin - Sun Exposed (Lower leg) (8.3), Minor Salivary Gland (7.3), Skin - Not Sun Exposed (Suprapubic) (4.3), and Cervix - Ectocervix (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPRR2B Gene

SOURCE GeneReport for Unigene cluster for SPRR2B Gene Hs.568239

mRNA Expression by UniProt/SwissProt for SPRR2B Gene

P35325-SPR2B_HUMAN
Tissue specificity: Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea
genes like me logo Genes that share expressions with SPRR2B: view

In Situ Assay Products

Orthologs for SPRR2B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SPRR2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRR2B 36
  • 100 (a)
OneToOne
Species with no ortholog for SPRR2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR2B Gene

ENSEMBL:
Gene Tree for SPRR2B (if available)
TreeFam:
Gene Tree for SPRR2B (if available)

Paralogs for SPRR2B Gene

Paralogs for SPRR2B Gene

genes like me logo Genes that share paralogs with SPRR2B: view

Variants for SPRR2B Gene

Sequence variations from dbSNP and Humsavar for SPRR2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs182561 -- 153,071,247(-) CTTCC(G/T)GAACA intron-variant
rs310102 -- 153,069,947(-) AAATA(A/G)TCTAA downstream-variant-500B
rs310103 -- 153,070,078(+) CAGAA(A/C)TAATA downstream-variant-500B
rs310104 -- 153,071,455(-) TTAGT(A/G/T)GATGG intron-variant
rs404408 -- 153,070,647(+) CTTTG(A/G)CTGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SPRR2B Gene

Variant ID Type Subtype PubMed ID
nsv464017 CNV Loss 19166990
esv2718239 CNV Deletion 23290073

Relevant External Links for SPRR2B Gene

HapMap Linkage Disequilibrium report
SPRR2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR2B Gene

Disorders for SPRR2B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SPRR2B Gene including...

Search for SPRR2B Gene in MalaCards »
genes like me logo Genes that share disorders with SPRR2B: view

No data available for UniProtKB/Swiss-Prot for SPRR2B Gene

Publications for SPRR2B Gene

  1. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3 4
  2. Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3. (PMID: 14748073) Lehr E. … Brown D. (J. Med. Virol. 2004) 3 23
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 3 4
  5. Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus. (PMID: 15232223) Hong S.H. … Kim M.K. (Mol. Cells 2004) 3

Products for SPRR2B Gene

Sources for SPRR2B Gene

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