Aliases for SPRR2B Gene
Aliases for SPRR2B Gene
External Ids for SPRR2B Gene
- HGNC: 11262
- Entrez Gene: 6701
- Ensembl: ENSG00000196805
- OMIM: 182268
- UniProtKB: P35325
Previous GeneCards Identifiers for SPRR2B Gene
- GC01M150859
- GC01M148825
- GC01M149818
- GC01M150259
- GC01M149825
- GC01M151278
- GC01M151309
- GC01M124405
Summaries for SPRR2B Gene
GeneCards Summary for SPRR2B Gene
SPRR2B (Small Proline Rich Protein 2B) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology. An important paralog of this gene is SPRR2A.
UniProtKB/Swiss-Prot for SPRR2B Gene
-
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Additional gene information for SPRR2B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2B Gene
Genomics for SPRR2B Gene
GeneHancer (GH) Regulatory Elements for SPRR2B Gene
Promoters and enhancers for SPRR2B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I153070 | Promoter | 0.5 | EPDnew | 550.8 | +0.8 | 837 | 0.1 | SPRR2B SPRR2A | ||
| GH01I153122 | Enhancer | 1.1 | Ensembl ENCODE | 6.9 | -52.0 | -51992 | 2.5 | CLOCK RB1 NEUROD1 KLF17 SIN3A FEZF1 YBX1 ZBTB40 RFX5 GLIS2 | SPRR2C SPRR2G LELP1 SPRR2B SPRR2F | |
| GH01I153094 | Promoter | 0.5 | EPDnew | 10.7 | -22.9 | -22937 | 0.1 | SPRR2E SPRR2B SPRR2C LELP1 SPRR2F | ||
| GH01I153119 | Enhancer | 0.6 | ENCODE | 6.9 | -48.0 | -47983 | 0.4 | MEIS2 LEF1 PKNOX1 RFX1 SOX6 NR4A1 CBFA2T3 DPF2 ZEB2 CTBP1 | SPRR2G SPRR2B SPRR2F SPRR2C | |
| GH01I153099 | Enhancer | 0.6 | ENCODE | 0.3 | -28.6 | -28564 | 2.3 | JUN MAX CEBPB EP300 RAD21 JUND MAFF CREB1 STAT3 SMC3 | SPRR2C SPRR1B SPRR2F SPRR2E SPRR2B |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around SPRR2B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for SPRR2B Gene
Genomic Locations for SPRR2B Gene
- chr1:153,070,224-153,071,608
- (GRCh38/hg38)
- Size:
- 1,385 bases
- Orientation:
- Minus strand
- chr1:153,042,700-153,113,927
- (GRCh37/hg19)
Genomic View for SPRR2B Gene
Genes around SPRR2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
SPRR2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPRR2B Gene
Proteins for SPRR2B Gene
-
Protein details for SPRR2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35325-SPR2B_HUMAN
- Recommended name:
- Small proline-rich protein 2B
- Protein Accession:
- P35325
- Q5T528
Protein attributes for SPRR2B Gene
- Size:
- 72 amino acids
- Molecular mass:
- 7975 Da
- Quaternary structure:
- No Data Available
Protein Expression for SPRR2B Gene
Post-translational modifications for SPRR2B Gene
No Post-translational modifications
Other Protein References for SPRR2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for SPRR2B
Protein Products
-
OriGene Purified Proteins for SPRR2B
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- antibodies-online: Search results for 3 available SPRR2B Proteins ranked by validation data
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-
Quality Products:
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Assay Products
- antibodies-online: Search results for 1 available SPRR2B Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for SPRR2B Gene
Domains & Families for SPRR2B Gene
Gene Families for SPRR2B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for SPRR2B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPRR2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35325- Family:
-
- Belongs to the cornifin (SPRR) family.
Function for SPRR2B Gene
Molecular function for SPRR2B Gene
- GENATLAS Biochemistry:
- small proline rich protein 2B,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
- UniProtKB/Swiss-Prot Function:
- Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
- UniProtKB/Swiss-Prot Induction:
- By UV irradiation and carcinogenic agents. During squamous differentiation of epidermal keratinocytes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IBA | -- |
Phenotypes for SPRR2B Gene
- GenomeRNAi human phenotypes for SPRR2B:
Animal Model Products
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-
-
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CRISPR Products
-
OriGene CRISPR knockouts for SPRR2B
- genomics-online: gRNA clones - Search results for available SPRR2B gene related products
- Applied Biological Materials CRISPR for SPRR2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRR2B
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SPRR2B gene related products
- orf clones - Search results for available SPRR2B gene related products
- Applied Biological Materials Clones for SPRR2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for SPRR2B
-
ViGene Biosciences adenoviral particle packaged cDNA for SPRR2B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPRR2B gene
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRR2B Gene
Localization for SPRR2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPRR2B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | TAS | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for SPRR2B Gene
Pathways & Interactions for SPRR2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratinization |
.33
|
|
| 2 | Developmental Biology | ||
Pathways by source for SPRR2B Gene
3 Reactome pathways for SPRR2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008544 | epidermis development | NAS | 8325635 |
| GO:0018149 | peptide cross-linking | IBA | -- |
| GO:0030216 | keratinocyte differentiation | NAS | 8325635 |
| GO:0031424 | keratinization | IEA | -- |
| GO:0070268 | cornification | TAS | -- |
No data available for SIGNOR curated interactions for SPRR2B Gene
Transcripts for SPRR2B Gene
mRNA/cDNA for SPRR2B Gene
- (2) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (87) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPRR2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPRR2B
- genomics-online: gRNA clones - Search results for available SPRR2B gene related products
- Applied Biological Materials CRISPR for SPRR2B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRR2B
- GenScript: Design CRISPR guide RNA sequences for SPRR2B
miRNA Products
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Inhibitory RNA Products
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- genomics-online: shRNA clones - Search results for available SPRR2B gene related products
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPRR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPRR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available SPRR2B gene related products
- orf clones - Search results for available SPRR2B gene related products
- Applied Biological Materials Clones for SPRR2B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for SPRR2B Gene
mRNA differential expression in normal tissues according to GTEx for SPRR2B Gene
This gene is overexpressed in Esophagus - Mucosa (x23.9), Skin - Sun Exposed (Lower leg) (x8.3), Minor Salivary Gland (x7.3), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Cervix - Ectocervix (x4.0).
This gene is overexpressed in Cervix (66.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRR2B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SPRR2B Gene:
SPRR2BSOURCE GeneReport for Unigene cluster for SPRR2B Gene:
Hs.568239mRNA Expression by UniProt/SwissProt for SPRR2B Gene:
P35325-SPR2B_HUMAN
Tissue specificity:
Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
Evidence on tissue expression from TISSUES for SPRR2B Gene
- Skin(4.4)
Primer Products
- genomics-online: primer clones - Search results for available SPRR2B gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRR2B Gene
Orthologs for SPRR2B Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPRR2B 34 |
|
OneToOne |
- Species where no ortholog for SPRR2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SPRR2B Gene
Variants for SPRR2B Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000162148 | -- | 153,073,444(-) | C/T | upstream_transcript_variant | |
| rs1000379882 | -- | 153,073,091(-) | C/G/T | upstream_transcript_variant | |
| rs1001881293 | -- | 153,069,829(-) | G/A | downstream_transcript_variant | |
| rs1002306000 | -- | 153,071,945(-) | T/C | upstream_transcript_variant | |
| rs1002399374 | -- | 153,072,184(-) | TCTGTCT/TCT | upstream_transcript_variant |
Residual Variation Intolerance Score:
66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.41% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for SPRR2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPRR2B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR2B Gene
Disorders for SPRR2B Gene
Additional Disease Information for SPRR2B
No disorders were found for SPRR2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR2B Gene
Publications for SPRR2B Gene
- Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S … Backendorf C (Genomics 1993) 2 3 4 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3. (PMID: 14748073) Lehr E … Brown D (Journal of medical virology 2004) 3 22 58
- Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A … Backendorf C (The Journal of biological chemistry 2001) 3 4 58
- Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. (PMID: 22374195) Epstein TG … Khurana Hershey GK (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2012) 3 58
Products for SPRR2B Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available SPRR2B related products ranked by validation data
- antibodies-online: Search results for 1 available SPRR2B Elisa Kits ranked by validation data
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- antibodies-online: Search results for 3 available SPRR2B Proteins ranked by validation data
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Sources for SPRR2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
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- (125) NCBI Bookshelf
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- (133) ENCODE
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
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- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew