SPRR2B Gene
protein-coding GIFtS: 39
GCID: GC01M153029
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small proline-rich protein 2B
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Aliases
for SPRR2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Proline-Rich Protein 2B1 2 | | SPR-2B2 3 |
Export aliases for SPRR2B gene to outside databasesPrevious GC identifers: GC01M150859 GC01M148825 GC01M149818 GC01M150259 GC01M149825 GC01M151278 GC01M151309 GC01M124405 |
Summaries
for SPRR2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPR2B_HUMAN, P35325Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membrane
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Genomic Views
for SPRR2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPRR2B gene promoter:
C/EBPbeta POU2F1 Nkx6-1 p53 POU2F1b POU2F1a c-Myb POU2F1c RORalpha2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPRR2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21-q22SPRR2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M153029: view genomic region
(about GC identifiers)
Start:
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153,042,704 bp from pter |
End:
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153,113,927 bp from pter |
Size:
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71,224 bases |
Orientation:
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minus strand |
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Proteins
for SPRR2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPR2B_HUMAN, P35325 (See
protein sequence)Recommended Name: Small proline-rich protein 2B Size: 72 amino acids; 7975 Da
Subcellular location: Cytoplasm
Developmental stage: Expressed during differentiation of squamous cells
Secondary accessions: Q5T528Explore the universe of human proteins at neXtProt for SPRR2B: NX_P35325
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35325
SPRR2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001017418.1
ENSEMBL proteins: ENSP00000357744 ENSP00000340703 ENSP00000357741
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPRR2B for ontologies About GeneDecksing
SPRR2B Antibody Products:
Assay Products for SPRR2B: |
Protein
Domains /
Families
for SPRR2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPRR2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P35325ProtoNet protein and cluster: P35325 1 Blocks protein family: IPB003267 Small proline-rich protein signature
UniProtKB/Swiss-Prot: SPR2B_HUMAN, P35325Similarity: Belongs to the cornifin (SPRR) family |
Function
for SPRR2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPR2B_HUMAN, P35325Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membraneInduction: By UV irradiation and carcinogenic agents. During squamous differentiation of epidermal keratinocytes Genatlas biochemistry entry for SPRR2B:small proline rich protein 2B,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiationcomplex (EDC)
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2B
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|
Pathways & Interactions
for SPRR2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRR2B
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SPRR2B for ontologies About GeneDecksing
|
Drugs & Compounds
for SPRR2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPRR2B
Search CenterWatch for drugs/clinical trials and news about SPRR2B / SPR2B
|
Transcripts
for SPRR2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPRR2B gene: NM_001017418.1 Unigene Cluster for SPRR2B: Small proline-rich protein 2B Hs.568239 [show with all ESTs]Unigene Representative Sequence: BG2052633 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368755 ENST00000341611(uc001fbg.3) ENST00000368752(uc001fbj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPRR2B (NM_001017418) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2B |
2 DOTS entries: DT.91674741 DT.91758274 24/87 AceView cDNA sequences (see all 87): BG183546 AW238280 AI860616 BG185626 BV199889 BV199888 BG197467 BG187580 AW780258 BE182189 BG201115 BG218533 BV203384 BG220895 AI276842 BV199891 BV199887 M21302 AW572396 BG214712 AW470486 BG192407 AI432162 BG194482
GeneLoc Exon Structure
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Expression
for SPRR2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPRR2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPRR2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRR2B
SOURCE GeneReport for Unigene cluster: Hs.568239
UniProtKB/Swiss-Prot: SPR2B_HUMAN, P35325Tissue specificity: Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue andtrachea
SABiosciences Custom PCR Arrays for SPRR2B
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPRR2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR2B |
Orthologs
for SPRR2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SPRR2B (if available)
TreeFam Gene Tree for SPRR2B (if available) |
Paralogs
for SPRR2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPRR2B gene
- SPRR1B2 SPRR42 SPRR2F2 SPRR2D2 SPRR2G2 SPRR1A2 SPRR2A2 SPRR2E2
- LELP12 SPRR32
SPRR2B for paralogs About GeneDecksing
|
Genomic Variants
for SPRR2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for SPRR2B (153042704 - 153113927 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPRR2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR2B |
|
Disorders
/ Diseases
for SPRR2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPRR2B for disorders About GeneDecksing
OMIM gene information: 182268
OMIM disorders: --
1  disease for SPRR2B: About MalaCardspsoriasis
Export disorders for SPRR2B gene to outside databases
|
Publications
for SPRR2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPRR2B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with SPRR2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PubMed id 8325635)1, 2, 3 Gibbs S.... Backendorf C. (1993)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PubMed id 11279051)1, 2 Cabral A....Backendorf C. (2001)
- Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3. (PubMed id 14748073)1, 9 Lehr E....Brown D. (2004)
- Genetic variation in small proline rich protein 2B as a predictor for asthma among children with eczema. (PubMed id 22374195)1 Epstein T.G....Khurana Hershey G.K. (2012)
- Four-gene expression model predictive of lymph node me tastases in oral squamous cell carcinoma. (PubMed id 21985131)1 Pasini F.S....Federico M.H. (2012)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PubMed id 18643845)1 Kainu K....Saarialho-Kere U. (2009)
- Expression and regulation of cornified envelope proteins in human corneal epithelium. (PubMed id 16639001)1 Tong L....Pflugfelder S.C. (2006)
- Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus. (PubMed id 15232223)1 Hong S.H....Kim M.K. (2004)
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External Searches for SPRR2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPRR2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPRR2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPRR2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPRR2B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPRR2B gene:
Search GeneIP for patents involving SPRR2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPRR2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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 | | | SPRR2B Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPRR2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2B |
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