Aliases for SPRR2B Gene
Aliases for SPRR2B Gene
External Ids for SPRR2B Gene
- HGNC: 11262
- Entrez Gene: 6701
- Ensembl: ENSG00000196805
- OMIM: 182268
- UniProtKB: P35325
Previous GeneCards Identifiers for SPRR2B Gene
- GC01M150859
- GC01M148825
- GC01M149818
- GC01M150259
- GC01M149825
- GC01M151278
- GC01M151309
- GC01M124405
Summaries for SPRR2B Gene
GeneCards Summary for SPRR2B Gene
SPRR2B (Small Proline Rich Protein 2B) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.
UniProtKB/Swiss-Prot for SPRR2B Gene
-
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2B Gene
Genomics for SPRR2B Gene
Regulatory Elements for SPRR2B Gene
Enhancers for SPRR2B Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G153122 | 1.2 | Ensembl ENCODE | 6.9 | -52.0 | -51992 | 2.5 | TBP FOXA2 SIN3A KLF17 FEZF1 YBX1 RAD21 ZBTB40 GLIS2 GATA2 | SPRR2C SPRR2G LELP1 SPRR2B SPRR2F |
| GH01G153119 | 0.7 | ENCODE | 6.9 | -48.0 | -47984 | 0.4 | LEF1 PKNOX1 ESRRA RFX1 NR2F1 NR4A1 DPF2 ZEB2 ARID1B NCOR1 | SPRR2G SPRR2B SPRR2F SPRR2C |
| GH01G153099 | 0.8 | ENCODE | 0.3 | -28.6 | -28564 | 2.3 | HDAC1 FOXA2 RAD21 TCF12 RCOR1 FOS CEBPB ZEB2 MAFF SMARCA4 | SPRR2C SPRR1B SPRR2F SPRR2E SPRR2B |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SPRR2B on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for SPRR2B Gene
- Chromosome:
- 1
- Start:
- 153,070,224 bp from pter
- End:
- 153,071,608 bp from pter
- Size:
- 1,385 bases
- Orientation:
- Minus strand
Genomic View for SPRR2B Gene
Genes around SPRR2B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
SPRR2B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SPRR2B Gene
Proteins for SPRR2B Gene
-
Protein details for SPRR2B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35325-SPR2B_HUMAN
- Recommended name:
- Small proline-rich protein 2B
- Protein Accession:
- P35325
- Q5T528
Protein attributes for SPRR2B Gene
- Size:
- 72 amino acids
- Molecular mass:
- 7975 Da
- Quaternary structure:
- No Data Available
Protein Expression for SPRR2B Gene
Post-translational modifications for SPRR2B Gene
Other Protein References for SPRR2B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Search GeneTex for Antibodies for SPRR2B
Protein Products
-
OriGene Purified Proteins for SPRR2B
- Search Origene for MassSpec and Protein Over-expression Lysates for SPRR2B
- Origene Custom Protein Services for SPRR2B
- antibodies-online Proteins for SPRR2B: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for SPRR2B
Assay Products
- antibodies-online Kits for SPRR2B: See all 1
No data available for DME Specific Peptides for SPRR2B Gene
Domains & Families for SPRR2B Gene
Gene Families for SPRR2B Gene
Protein Domains for SPRR2B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for SPRR2B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35325- Family:
-
- Belongs to the cornifin (SPRR) family.
Function for SPRR2B Gene
Molecular function for SPRR2B Gene
- GENATLAS Biochemistry:
- small proline rich protein 2B,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
- UniProtKB/Swiss-Prot Function:
- Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
- UniProtKB/Swiss-Prot Induction:
- By UV irradiation and carcinogenic agents. During squamous differentiation of epidermal keratinocytes.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005198 | structural molecule activity | IBA | -- |
Phenotypes for SPRR2B Gene
- GenomeRNAi human phenotypes for SPRR2B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPRR2B
-
-
ViGene Biosciences lentiviral particle packaged cDNA for SPRR2B gene
- Search ViGene Biosciences for SPRR2B
CRISPR Products
-
OriGene CRISPR knockouts for SPRR2B
-
Applied Biological Materials CRISPR for SPRR2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRR2B
- GenScript: Design CRISPR guide RNA sequences for SPRR2B
miRNA Products
- Search ViGene Biosciences for SPRR2B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SPRR2B
- Browse OriGene Inhibitory RNA Products For SPRR2B
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Clone Products
-
OriGene ORF clones in human for SPRR2B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPRR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPRR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for SPRR2B
-
ViGene Biosciences adenoviral particle packaged cDNA for SPRR2B gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SPRR2B gene
- Search ViGene Biosciences for SPRR2B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRR2B Gene
Localization for SPRR2B Gene
Subcellular locations from UniProtKB/Swiss-Prot for SPRR2B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001533 | cornified envelope | TAS | -- |
| GO:0005737 | cytoplasm | IBA,IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for SPRR2B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Keratinization |
.33
|
|
| 2 | Developmental Biology | ||
Pathways by source for SPRR2B Gene
3 Reactome pathways for SPRR2B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008544 | epidermis development | NAS | 8325635 |
| GO:0018149 | peptide cross-linking | IBA | -- |
| GO:0030216 | keratinocyte differentiation | NAS | 8325635 |
| GO:0031424 | keratinization | IEA | -- |
| GO:0070268 | cornification | TAS | -- |
No data available for SIGNOR curated interactions for SPRR2B Gene
Transcripts for SPRR2B Gene
mRNA/cDNA for SPRR2B Gene
- (2) REFSEQ mRNAs :
- (0) Additional mRNA sequences :
- -
- (87) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SPRR2B Gene
CRISPR Products
-
OriGene CRISPR knockouts for SPRR2B
-
Applied Biological Materials CRISPR for SPRR2B
-
Santa Cruz Biotechnology (SCBT) CRISPR for SPRR2B
- GenScript: Design CRISPR guide RNA sequences for SPRR2B
miRNA Products
- Search ViGene Biosciences for SPRR2B
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for SPRR2B
- Browse OriGene Inhibitory RNA Products For SPRR2B
- Search ViGene Biosciences for SPRR2B
Clone Products
-
OriGene ORF clones in human for SPRR2B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for SPRR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPRR2B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for SPRR2B Gene
mRNA differential expression in normal tissues according to GTEx for SPRR2B Gene
This gene is overexpressed in Esophagus - Mucosa (x23.9), Skin - Sun Exposed (Lower leg) (x8.3), Minor Salivary Gland (x7.3), Skin - Not Sun Exposed (Suprapubic) (x4.3), and Cervix - Ectocervix (x4.0).
This gene is overexpressed in Cervix (66.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRR2B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SPRR2B Gene:
SPRR2BSOURCE GeneReport for Unigene cluster for SPRR2B Gene:
Hs.568239mRNA Expression by UniProt/SwissProt for SPRR2B Gene:
P35325-SPR2B_HUMAN
Tissue specificity:
Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
Evidence on tissue expression from TISSUES for SPRR2B Gene
- Skin(4.4)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPRR2B Gene
Orthologs for SPRR2B Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SPRR2B 35 |
|
OneToOne |
- Species where no ortholog for SPRR2B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for SPRR2B Gene
No data available for Paralogs for SPRR2B Gene
Variants for SPRR2B Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000162148 | -- | 153,073,444(+) | AGACT(C/T)CCCTT | upstream-variant-2KB | |
| rs1000379882 | -- | 153,073,091(+) | CACCT(C/T)TCAGT | upstream-variant-2KB | |
| rs1001881293 | -- | 153,069,829(+) | CTTCT(A/G)GGGGA | downstream-variant-500B | |
| rs1002306000 | -- | 153,071,945(+) | CATAT(C/T)GTTGT | upstream-variant-2KB | |
| rs1002399374 | -- | 153,072,184(+) | TCACC(-/TCTG)TCTTT | upstream-variant-2KB |
Residual Variation Intolerance Score:
66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.63;
13.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SPRR2B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SPRR2B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR2B Gene
Disorders for SPRR2B Gene
Relevant External Links for SPRR2B
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- SPRR2B
No disorders were found for SPRR2B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR2B Gene
Publications for SPRR2B Gene
- Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3 4 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3. (PMID: 14748073) Lehr E. … Brown D. (J. Med. Virol. 2004) 3 22 64
- Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. (PMID: 11279051) Cabral A. … Backendorf C. (J. Biol. Chem. 2001) 3 4 64
- Four-gene expression model predictive of lymph node metastases in oral squamous cell carcinoma. (PMID: 21985131) Pasini F.S. … Federico M.H. (Acta Oncol 2012) 3 64
Products for SPRR2B Gene
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- Browse R&D Systems for biochemical assays
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- Cloud-Clone Corp. primary cells service
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Search antibodies-online for antibodies
- antibodies-online Kits for SPRR2B: See all 1
- antibodies-online Proteins for SPRR2B: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for SPRR2B
- Search GeneTex for Proteins for SPRR2B
- ViGene Biosciences adenoviral particle packaged cDNA for SPRR2B gene
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- Horizon Cell Lines for SPRR2B
- Cyagen custom Knockout/knockin (KOKI) mouse models for SPRR2B
- VectorBuilder custom plasmid, inducible vectors for SPRR2B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for SPRR2B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SPRR2B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (118) ClinicalTrials
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- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio