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Aliases for SPRR2A Gene

Aliases for SPRR2A Gene

  • Small Proline-Rich Protein 2A 2 3
  • SPR-2A 3 4
  • 2-1 3 4

External Ids for SPRR2A Gene

Previous GeneCards Identifiers for SPRR2A Gene

  • GC01M150829
  • GC01M148811
  • GC01M149803
  • GC01M150245
  • GC01M149842
  • GC01M151295
  • GC01M124391

Summaries for SPRR2A Gene

GeneCards Summary for SPRR2A Gene

SPRR2A (Small Proline-Rich Protein 2A) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPRR2A Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane

Gene Wiki entry for SPRR2A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR2A Gene

Genomics for SPRR2A Gene

Regulatory Elements for SPRR2A Gene

Genomic Location for SPRR2A Gene

Chromosome:
1
Start:
153,056,113 bp from pter
End:
153,057,537 bp from pter
Size:
1,425 bases
Orientation:
Minus strand

Genomic View for SPRR2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR2A Gene

Proteins for SPRR2A Gene

  • Protein details for SPRR2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35326-SPR2A_HUMAN
    Recommended name:
    Small proline-rich protein 2A
    Protein Accession:
    P35326
    Secondary Accessions:
    • B2R4T3
    • D3DV35
    • Q5T529

    Protein attributes for SPRR2A Gene

    Size:
    72 amino acids
    Molecular mass:
    7965 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR2A Gene

Proteomics data for SPRR2A Gene at MOPED

Post-translational modifications for SPRR2A Gene

No Post-translational modifications

Other Protein References for SPRR2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR2A Gene

Domains & Families for SPRR2A Gene

Protein Domains for SPRR2A Gene

Suggested Antigen Peptide Sequences for SPRR2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35326

UniProtKB/Swiss-Prot:

SPR2A_HUMAN :
  • Belongs to the cornifin (SPRR) family.
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR2A: view

No data available for Gene Families for SPRR2A Gene

Function for SPRR2A Gene

Molecular function for SPRR2A Gene

GENATLAS Biochemistry:
small proline rich protein 2,precursor of cornified cell envelope,cornifin,associating with the nuclear matrix,putative target for ELF3,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane
UniProtKB/Swiss-Prot Induction:
During squamous differentiation of epidermal keratinocytes

Gene Ontology (GO) - Molecular Function for SPRR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IBA --
GO:0005515 protein binding IPI 18155796
genes like me logo Genes that share ontologies with SPRR2A: view

Phenotypes for SPRR2A Gene

GenomeRNAi human phenotypes for SPRR2A:
genes like me logo Genes that share phenotypes with SPRR2A: view

Animal Model Products

miRNA for SPRR2A Gene

miRTarBase miRNAs that target SPRR2A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR2A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRR2A Gene

Localization for SPRR2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR2A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR2A Gene COMPARTMENTS Subcellular localization image for SPRR2A gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SPRR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope NAS 8325635
GO:0005737 cytoplasm IDA 16639001
genes like me logo Genes that share ontologies with SPRR2A: view

Pathways & Interactions for SPRR2A Gene

SuperPathways for SPRR2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPRR2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development NAS 8325635
GO:0018149 peptide cross-linking IBA --
GO:0030216 keratinocyte differentiation NAS 8325635
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with SPRR2A: view

No data available for Pathways by source and SIGNOR curated interactions for SPRR2A Gene

Drugs & Compounds for SPRR2A Gene

(1) Drugs for SPRR2A Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra 0
genes like me logo Genes that share compounds with SPRR2A: view

Transcripts for SPRR2A Gene

mRNA/cDNA for SPRR2A Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR2A Gene

Small proline-rich protein 2A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR2A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR2A Gene

No ASD Table

Relevant External Links for SPRR2A Gene

GeneLoc Exon Structure for
SPRR2A
ECgene alternative splicing isoforms for
SPRR2A

Expression for SPRR2A Gene

mRNA expression in normal human tissues for SPRR2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRR2A Gene

This gene is overexpressed in Esophagus - Mucosa (x31.7), Minor Salivary Gland (x7.6), Cervix - Ectocervix (x7.4), and Vagina (x6.0).

Protein differential expression in normal tissues from HIPED for SPRR2A Gene

This gene is overexpressed in Cervix (49.5) and Esophagus (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRR2A Gene



SOURCE GeneReport for Unigene cluster for SPRR2A Gene Hs.355542

genes like me logo Genes that share expression patterns with SPRR2A: view

Protein tissue co-expression partners for SPRR2A Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPRR2A Gene

Orthologs for SPRR2A Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SPRR2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRR2A 35
  • 100 (n)
  • 100 (a)
SPRR2A 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sprr2a1 16
Species with no ortholog for SPRR2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR2A Gene

ENSEMBL:
Gene Tree for SPRR2A (if available)
TreeFam:
Gene Tree for SPRR2A (if available)

Paralogs for SPRR2A Gene

No data available for Paralogs for SPRR2A Gene

Variants for SPRR2A Gene

Sequence variations from dbSNP and Humsavar for SPRR2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs391534 -- 153,056,507(-) TTCAG(A/G)ATTCA utr-variant-3-prime
rs447187 -- 153,057,485(-) GATCT(A/G)CCTTG utr-variant-5-prime
rs454245 -- 153,059,503(+) CATTC(A/C)AACAG upstream-variant-2KB
rs1998818 -- 153,057,832(+) TCTTA(C/T)ACCTT upstream-variant-2KB
rs3737863 -- 153,056,403(+) GAGAA(A/G)GAAGC utr-variant-3-prime

Variation tolerance for SPRR2A Gene

Residual Variation Intolerance Score: 65.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.00; 0.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRR2A Gene

HapMap Linkage Disequilibrium report
SPRR2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPRR2A Gene

Disorders for SPRR2A Gene

Relevant External Links for SPRR2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRR2A
genes like me logo Genes that share disorders with SPRR2A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR2A Gene

Publications for SPRR2A Gene

  1. Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. (PMID: 18155796) Demetris A.J. … Wu T. (J. Hepatol. 2008) 23 67
  2. Small proline-rich proteins 2 are noncoordinately upregulated by IL-6/STAT3 signaling after bile duct ligation. (PMID: 15558059) Nozaki I. … Demetris A.J. (Lab. Invest. 2005) 23 67
  3. Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. (PMID: 14647409) Luo A. … Liu Z. (Oncogene 2004) 23 67
  4. Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. (PMID: 12624109) Cabral A. … Backendorf C. (J. Biol. Chem. 2003) 23 67
  5. Up-regulated gene expression in the conjunctival epithelium of patients with SjAPgren's syndrome. (PMID: 12823984) Kawasaki S. … Okubo K. (Exp. Eye Res. 2003) 23 67

Products for SPRR2A Gene

Sources for SPRR2A Gene

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