SPRR2A Gene
protein-coding GIFtS: 44
GCID: GC01M153028
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small proline-rich protein 2A
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Aliases
for SPRR2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Small Proline-Rich Protein 2A1 2 | | 2-12 3 | | SPR-2A2 3 |
Export aliases for SPRR2A gene to outside databasesPrevious GC identifers: GC01M150829 GC01M148811 GC01M149803 GC01M150245 GC01M149842 GC01M151295 GC01M124391 |
Summaries
for SPRR2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPR2A_HUMAN, P35326Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membrane
Gene Wiki entry for SPRR2A
|
Genomic Views
for SPRR2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPRR2A gene promoter:
C/EBPbeta Pbx1a p53 Nkx6-1 POU2F1 POU2F1b POU2F1a c-Myb Msx-1 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPRR2A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR2A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21-q22SPRR2A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M153028: view genomic region
(about GC identifiers)
Start:
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153,028,589 bp from pter |
End:
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153,030,013 bp from pter |
Size:
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1,425 bases |
Orientation:
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minus strand |
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Proteins
for SPRR2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPR2A_HUMAN, P35326 (See
protein sequence)Recommended Name: Small proline-rich protein 2A Size: 72 amino acids; 7965 Da
Subcellular location: Cytoplasm
Secondary accessions: B2R4T3 D3DV35 Q5T529Explore the universe of human proteins at neXtProt for SPRR2A: NX_P35326
SPRR2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005979.1
ENSEMBL proteins: ENSP00000376423
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SPRR2A for ontologies About GeneDecksing
SPRR2A Antibody Products:
Assay Products for SPRR2A: |
Protein
Domains /
Families
for SPRR2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPRR2A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P35326ProtoNet protein and cluster: P35326 1 Blocks protein family: IPB003267 Small proline-rich protein signature
UniProtKB/Swiss-Prot: SPR2A_HUMAN, P35326Similarity: Belongs to the cornifin (SPRR) family |
Function
for SPRR2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPR2A_HUMAN, P35326Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cellcytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in theformation of an insoluble envelope beneath the plasma membraneInduction: During squamous differentiation of epidermal keratinocytes Genatlas biochemistry entry for SPRR2A:small proline rich protein 2,precursor of cornified cell envelope,cornifin,associating with the nuclear matrix,putativetarget for ELF3,clustered in the epidermal differentiation complex (EDC)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: SPRR2A (NM_005988) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005488 | binding |
-- | -- |
SPRR2A for ontologies About GeneDecksing
|
Pathways & Interactions
for SPRR2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPRR2A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/11 Interacting proteins for SPRR2A (P353262, 3 ENSP000003764234) via UniProtKB, MINT, STRING, and/or I2D (see all 11)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| ABL1 | P005192, 3, ENSP000003614234 | MINT-7304327 I2D:
score=1 STRING: ENSP00000361423 | | CRK | P461082, 3, ENSP000003005744 | MINT-7304314 I2D:
score=1 STRING: ENSP00000300574 | | CTTN | Q142472, 3, ENSP000003018434 | MINT-7304360 I2D:
score=1 STRING: ENSP00000301843 | | DLG4 | P783522, 3, ENSP000002938134 | MINT-7304301 I2D:
score=1 STRING: ENSP00000293813 | | HCK | P086312, 3, ENSP000003650124 | MINT-7304343 I2D:
score=1 STRING: ENSP00000365012 |
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
SPRR2A for ontologies About GeneDecksing
|
Drugs & Compounds
for SPRR2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SPRR2A for compounds About GeneDecksing
 Browse Tocris compounds for SPRR2A
1 Novoseek chemical compound relationship for SPRR2A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| calcium |
0 |
1 |
10413601 (1) |
Search CenterWatch for drugs/clinical trials and news about SPRR2A / SPR2A
|
Transcripts
for SPRR2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPRR2A gene: NM_005988.2 Unigene Cluster for SPRR2A: Small proline-rich protein 2A Hs.355542 [show with all ESTs]Unigene Representative Sequence: BG1995841 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000392653(uc001fbd.3 uc001fbf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPRR2A (NM_005988) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRR2A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2A |
Additional cDNA sequence: AK311939.1 BC096108.1 BC096109.1 BC096110.1 BC096111.1 BC128049.1 5 DOTS entries: DT.91674741 DT.91758278 DT.91758282 DT.95375946 DT.95252248 15 AceView cDNA sequences: BE181484 BE181478 BE181596 BE181477 BE181113 BE182589 BE710505 BE181486 BE714433 BE714993 BF830417 BE181074 BE182586 BE182593 BE181521
GeneLoc Exon Structure
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Expression
for SPRR2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPRR2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGATCCCTG
About this image
See SPRR2A Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.355542
SABiosciences Custom PCR Arrays for SPRR2A
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPRR2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR2A |
Orthologs
for SPRR2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for SPRR2A (if available)
TreeFam Gene Tree for SPRR2A (if available) |
Paralogs
for SPRR2A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPRR2A gene
- SPRR1B2 SPRR42 SPRR2F2 SPRR2B2 SPRR2D2 SPRR2G2 SPRR1A2 SPRR2E2
- LELP12 SPRR32
SPRR2A for paralogs About GeneDecksing
|
Genomic Variants
for SPRR2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPRR2A (153028589 - 153030013 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPRR2A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR2A |
|
Disorders
/ Diseases
for SPRR2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPRR2A for disorders About GeneDecksing
OMIM gene information: 182267
OMIM disorders: --
8  diseases for SPRR2A: About MalaCardsesophageal squamous cell carcinoma squamous cell carcinoma anus cancer sjogren's syndrome
esophagitis gastric cancer psoriasis carcinoma
1 Novoseek disease relationship for SPRR2A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0 |
1 |
10773884 (1) |
Export disorders for SPRR2A gene to outside databases
|
Publications
for SPRR2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPRR2A gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with SPRR2A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PubMed id 8325635)1, 2, 3 Gibbs S.... Backendorf C. (1993)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes. (PubMed id 2388825)1, 2 Gibbs S.... Backendorf C. (1990)
- Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker. (PubMed id 9826750)1, 9 Fischer D.F....Backendorf C. (1998)
- Small proline-rich proteins (SPRR) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. (PubMed id 18155796)1, 9 Demetris A.J....Wu T. (2008)
- Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation. (PubMed id 12624109)1, 9 Cabral A.... Backendorf C. (2003)
- Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation. (PubMed id 8816448)1, 9 Fischer D.F....Backendorf C. (1996)
- Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. (PubMed id 18643845)1 Kainu K....Saarialho-Kere U. (2009)
- Expression and regulation of cornified envelope proteins in human corneal epithelium. (PubMed id 16639001)1 Tong L....Pflugfelder S.C. (2006)
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External Searches for SPRR2A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPRR2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPRR2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPRR2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPRR2A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPRR2A gene:
Search GeneIP for patents involving SPRR2A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPRR2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPRR2A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRR2A | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for SPRR2A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPRR2A | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRR2A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPRR2A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPRR2A | | OriGene Custom Protein Services for SPRR2A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRR2A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRR2A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR2A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR2A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR2A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR2A |
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| | | | Search Tocris compounds for SPRR2A |
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 | | | SPRR2A Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for SPRR2A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR2A |
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