Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRR1B Gene

protein-coding   GIFtS: 55
GCID: GC01P153003

Small Proline-Rich Protein 1B


(Previous symbol: SPRR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Small Proline-Rich Protein 1B1 2     cornifin1
SPRR11 2     CORNIFIN2
Small Proline-Rich Protein IB2 3     GADD332
14.9 KDa Pancornulin2 3     Cornifin B2
SPR-IB2 3     cornifin-B2

External Ids:    HGNC: 112601   Entrez Gene: 66992   Ensembl: ENSG000001694697   OMIM: 1822665   UniProtKB: P225283   

Export aliases for SPRR1B gene to outside databases

Previous GC identifers: GC01P150819 GC01P148786 GC01P149778 GC01P150220 GC01P149816 GC01P151270 GC01P124366


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPRR1B Gene: 
SPRR1B (small proline-rich protein 1B) is a protein-coding gene. Diseases associated with SPRR1B include ichthyosis vulgaris, and cervical intraepithelial neoplasia. GO annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is SPRR1A.

UniProtKB/Swiss-Prot: SPR1B_HUMAN, P22528
Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the
cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in
the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor
in transglutaminase-mediated cross-linkage

Gene Wiki entry for SPRR1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRR1B gene promoter:
         TBP   Sp1   AP-1   C/EBPalpha   AREB6   CHOP-10   Zic1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRR1B promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRR1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21-q22

SPRR1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRR1B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P153003:  view genomic region     (about GC identifiers)

Start:
153,003,678 bp from pter      End:
153,005,376 bp from pter
Size:
1,699 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPR1B_HUMAN, P22528 (See protein sequence)
Recommended Name: Cornifin-B  
Size: 89 amino acids; 9888 Da
Subcellular location: Cytoplasm
Developmental stage: Expressed during differentiation of squamous cells
Secondary accessions: B2R5H7 P22529 P22530 Q5T524

Explore the universe of human proteins at neXtProt for SPRR1B: NX_P22528

Explore proteomics data for SPRR1B at MOPED 

Post-translational modifications:

  • UniProtKB: The N-terminus is blocked
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22528

  • SPRR1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPRR1B Protein Expression
    REFSEQ proteins: NP_003116.2  
    ENSEMBL proteins: 
     ENSP00000306461   ENSP00000376429  

    Human Recombinant Protein Products for SPRR1B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SPRR1B
    GenScript Custom Purified and Recombinant Proteins Services for SPRR1B
    Novus Biologicals SPRR1B Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPRR1B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001533cornified envelope IDA10908733
    GO:0005737cytoplasm IEA--

    SPRR1B for ontologies           About GeneDecksing



    SPRR1B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPRR1B
    GenScript Custom Superior Antibodies Services for SPRR1B
    Abcam antibodies for SPRR1B
    Cloud-Clone Corp. Antibodies for SPRR1B 
    ThermoFisher Antibodies for SPRR1B
    LSBio Antibodies in human, mouse, rat for SPRR1B 

    Assay Products for SPRR1B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPRR1B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPRR1B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPRR1B 
    Cloud-Clone Corp. CLIAs for SPRR1B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR026075 SPRR/LCE
     IPR003302 Cornifin

    Graphical View of Domain Structure for InterPro Entry P22528

    ProtoNet protein and cluster: P22528

    2 Blocks protein domains:
    IPB003267 Small proline-rich protein signature
    IPB003302 Cornifin (SPRR)


    UniProtKB/Swiss-Prot: SPR1B_HUMAN, P22528
    Similarity: Belongs to the cornifin (SPRR) family


    SPRR1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPR1B_HUMAN, P22528
    Function: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the
    cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in
    the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor
    in transglutaminase-mediated cross-linkage
    Induction: By carcinogenic agents and by UV light. During squamous differentiation of epidermal keratinocytes

         Genatlas biochemistry entry for SPRR1B:
    small proline rich protein 1B,14kDa,precursor of cornified cell envelope,cornifin,clustered in the epidermal
    differentiation complex (EDC)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity IDA10908733
    GO:0030674protein binding, bridging IDA10908733
         
    SPRR1B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPRR1B:
     Decreased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRR1B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPRR1B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRR1B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRR1B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRR1B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPRR1B
    SwitchGear 3'UTR luciferase reporter plasmidSPRR1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPRR1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR1B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPRR1B
    Sirion Biotech Customized adenovirus for overexpression of SPRR1B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SPRR1B (see all 4)
    OriGene ORF clones in mouse, rat for SPRR1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRR1B (NM_003125)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR1B
    Sirion Biotech Customized lentivirus for stable overexpression of SPRR1B 
                         Customized lentivirus expression plasmids for stable overexpression of SPRR1B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPRR1B
    Search LifeMap BioReagents cell lines for SPRR1B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR1B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRR1B

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPRR1B (P225283 ENSP000003064614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    USF2Q158533, ENSP000002223054I2D: score=1 STRING: ENSP00000222305
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008544epidermis development TAS1627333
    GO:0018149peptide cross-linking IDA10908733
    GO:0030216keratinocyte differentiation IDA10908733
    GO:0031424keratinization IEA--

    SPRR1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPRR1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRR1B (SPR1B)

    5 Novoseek inferred chemical compound relationships for SPRR1B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 57.6 8 8370963 (3), 10389939 (2), 11205873 (1), 8747384 (1) (see all 5)
    proline 50.5 4 8809402 (1), 1438308 (1), 7593315 (1)
    diethylstilbestrol 43.7 1 8912806 (1)
    dexamethasone 5.48 1 8912806 (1)
    calcium 0 1 8618063 (1)

    Search CenterWatch for drugs/clinical trials and news about SPRR1B / SPR1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRR1B gene: 
    NM_003125.2  

    Unigene Cluster for SPRR1B:

    Small proline-rich protein 1B
    Hs.1076  [show with all ESTs]
    Unigene Representative Sequence: AI541215
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307098(uc001fba.3) ENST00000392661
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPRR1B
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPRR1B
    SwitchGear 3'UTR luciferase reporter plasmidSPRR1B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPRR1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR1B
    Clone
    Products:
         
    OriGene clones in human, mouse for SPRR1B (see all 4)
    OriGene ORF clones in mouse, rat for SPRR1B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPRR1B (NM_003125)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRR1B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR1B
    Sirion Biotech Customized lentivirus for stable overexpression of SPRR1B 
                         Customized lentivirus expression plasmids for stable overexpression of SPRR1B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SPRR1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPRR1B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR1B
      Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR1B

    Additional mRNA sequence: 

    AK312191.1 BC056240.1 DQ323996.1 M19888.1 M21300.1 M21301.1 

    5 DOTS entries:

    DT.312392  DT.121443262  DT.95160284  DT.95160281  DT.95259492 

    24/82 AceView cDNA sequences (see all 82):

    CK300778 W77949 AA587019 AA587163 AW137292 BG319578 BC056240 T28446 
    AA447684 AA582893 AA122335 BV178563 AI285828 AI368120 BM968490 BQ189648 
    W72751 BG220727 AI588998 BE932410 M19888 BU600928 M21300 BX119256 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRR1B expression in normal human tissues (normalized intensities)      SPRR1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTTGAGGA
    SPRR1B Expression
    About this image


    SPRR1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 6 entries
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Basal Cells Respiratory Bronchioles
             Human Bronchial Epithelial Cells (HBEpiC)   
     
     Epidermis (Integumentary System)    fully expand to see all 2 entries
             Human EpiDermal Keratinocytes (HEK)   
     
     Eye (Sensory Organs)
             Human Corneal Epithelial Cells (HCEpiC)   
     
     Fibroblast
             Human Dermal Fibroblasts-fetal (HDF-f)   

    See SPRR1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPRR1B

    SOURCE GeneReport for Unigene cluster: Hs.1076

    UniProtKB/Swiss-Prot: SPR1B_HUMAN, P22528
    Tissue specificity: Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and
    trachea

        SABiosciences Custom PCR Arrays for SPRR1B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SPRR1B
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SPRR1B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR1B
    Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SPRR1B gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sprr1b5 small proline-rich protein 1B   --   3 (40.14 cM) 92436809 


    ENSEMBL Gene Tree for SPRR1B (if available)
    TreeFam Gene Tree for SPRR1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPRR1B gene
    SPRR1A2  SPRR32  
    4 SIMAP similar genes for SPRR1B using alignment to 2 protein entries:     SPR1B_HUMAN (see all proteins):
    SPRR1A    SPRR3    SPRR4    TTN

    SPRR1B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/153 SNPs in SPRR1B are shown (see all 153)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0021654
    ----see VAR_0021652 V L mis40--------
    VAR_0021644
    ----see VAR_0021642 Q H mis40--------
    VAR_0021664
    ----see VAR_0021662 A P mis40--------
    rs1393694961,2
    --153001683(+) TGAAAG/TCTCCC 1 -- us2k10--------
    rs38062201,2
    C,F,H--153001688(+) GCTCCC/GCCAAG 1 -- us2k112Minor allele frequency- G:0.12NS EA CSA WA 1658
    rs795800951,2
    C,F--153001769(+) CCTGGG/ACCTGG 1 -- us2k12Minor allele frequency- A:0.04WA EA 238
    rs1432799151,2
    C--153001776(+) CTGGCA/GGCATG 1 -- us2k10--------
    rs1475189151,2
    --153001828(+) ATCCCA/TCCATA 1 -- us2k10--------
    rs1400597401,2
    --153001831(+) CCACCA/CTATTG 1 -- us2k10--------
    rs1914349711,2
    --153001846(+) CAAAGC/TGTGCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPRR1B (153003678 - 153005376 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SPRR1B: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRR1B
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRR1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182266    OMIM disorders: --

    16 diseases for SPRR1B:    About MalaCards
    ichthyosis vulgaris    cervical intraepithelial neoplasia    epidermolytic hyperkeratosis    verrucous carcinoma
    skin disease    vaginitis    ichthyosis    eye disease
    cholesteatoma    atopic dermatitis    dermatitis    cervicitis
    psoriasis    alcoholism    gastric cancer    esophagitis

    2 diseases from the University of Copenhagen DISEASES database for SPRR1B:
    Cholesteatoma     Epidermolytic hyperkeratosis

    SPRR1B for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for SPRR1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metaplasia 54.6 4 8624253 (2), 20042643 (1), 8370963 (1)
    cervical intraepithelial neoplasia 36.4 1 10389939 (1)
    premalignant 30 1 7698221 (1)
    carcinoma squamous cell 21 1 7698221 (1)
    skin diseases 16.3 1 11069449 (1)
    tumors 0 2 7698221 (2)

    Genetic Association Database (GAD): SPRR1B
    Human Genome Epidemiology (HuGE) Navigator: SPRR1B (1 document)

    Export disorders for SPRR1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRR1B gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with SPRR1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids. (PubMed id 1438308)1, 3, 9 Marvin K.W....Jetten A.M. (1992)
    2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PubMed id 8325635)1, 3, 9 Gibbs S.... Backendorf C. (1993)
    3. Variation in genes of the epidermal differentiation c omplex in German atopic dermatitis patients. (PubMed id 19601998)1, 4 Stemmler S....Hoffjan S. (2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation. (PubMed id 7829876)1, 2 Greco M.A....Kvedar J.C. (1995)
    7. Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP. (PubMed id 8388378)1, 2 An G. and Wu R. (1993)
    8. Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes. (PubMed id 3133554)1, 2 Kartasova T. and van de Putte P. (1988)
    9. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. (PubMed id 18172072)1, 9 Li S....McNamara N.A. (2008)
    10. Cloning and regulation of cornifin beta, a new member of the cornifin/spr family. Suppression by retinoic acid receptor-selective retinoids. (PubMed id 8631988)1, 9 Austin S.J....Jetten A.M. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6699 HGNC: 11260 AceView: SPRR1B Ensembl:ENSG00000169469 euGenes: HUgn6699
    ECgene: SPRR1B H-InvDB: SPRR1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRR1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPRR1B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/sprr1b/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPRR1B gene:
    Search GeneIP for patents involving SPRR1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPRR1B  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SPRR1B  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPRR1B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SPRR1B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPRR1B   OriGene Custom Protein Services for SPRR1B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRR1B
     QIAGEN SeqTarget long-range PCR primers for resequencing SPRR1B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRR1B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRR1B
     Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRR1B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRR1B
     GenScript Custom Purified and Recombinant Proteins Services for SPRR1B GenScript cDNA clones with any tag delivered in your preferred vector for SPRR1B
     GenScript Custom Assay Services for SPRR1B GenScript Custom Superior Antibodies Services for SPRR1B
     GenScript Custom overexpressing Cell Line Services for SPRR1B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SPRR1B promoter
     Search Chromatin IP Primers for SPRR1B
     RT2 qPCR Primer Assay in human, mouse / rat SPRR1B
     Search GNC Networks for SPRR1B
     SABiosciences Custom PCR Arrays for SPRR1B
     Search Tocris compounds for SPRR1B (SPR1B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPRR1B proteins
     Antibodies for SPRR1B
     See all of Abcam's Antibodies, Kits and Proteins for SPRR1B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SPRR1B
     Antibodies for SPRR1B
     ELISAs for SPRR1B
     CLIAs for SPRR1B
     Search LifeMap BioReagents cell lines for SPRR1B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRR1B
     SwitchGear 3'UTR luciferase reporter plasmids for SPRR1B
     SwitchGear Promoter luciferase reporter plasmids for SPRR1B
     ThermoFisher Antibodies for SPRR1B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRR1B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRR1B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPRR1B
    Customized:
     lentivirus for stable overexpression of SPRR1B
     lentivirus expression plasmids for stable overexpression of SPRR1B
     adenovirus for overexpression of SPRR1B
     LSBio Antibodies in human, mouse, rat for SPRR1B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPRR1B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4