Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPRR1B Gene

Aliases for SPRR1B Gene

  • Small Proline Rich Protein 1B 2 3
  • Small Proline-Rich Protein 1B 2 3 5
  • Small Proline-Rich Protein IB 3 4
  • 14.9 KDa Pancornulin 3 4
  • SPR-IB 3 4
  • Cornifin B 3
  • Cornifin 2
  • CORNIFIN 3
  • GADD33 3
  • SPRR1 3

External Ids for SPRR1B Gene

Previous HGNC Symbols for SPRR1B Gene

  • SPRR1

Previous GeneCards Identifiers for SPRR1B Gene

  • GC01P150819
  • GC01P148786
  • GC01P149778
  • GC01P150220
  • GC01P149816
  • GC01P151270
  • GC01P153003
  • GC01P124366

Summaries for SPRR1B Gene

Entrez Gene Summary for SPRR1B Gene

  • The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]

GeneCards Summary for SPRR1B Gene

SPRR1B (Small Proline Rich Protein 1B) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is SPRR3.

UniProtKB/Swiss-Prot for SPRR1B Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.

Gene Wiki entry for SPRR1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR1B Gene

Genomics for SPRR1B Gene

Regulatory Elements for SPRR1B Gene

Genomic Location for SPRR1B Gene

Chromosome:
1
Start:
153,031,202 bp from pter
End:
153,032,900 bp from pter
Size:
1,699 bases
Orientation:
Plus strand

Genomic View for SPRR1B Gene

Genes around SPRR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR1B Gene

Proteins for SPRR1B Gene

  • Protein details for SPRR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22528-SPR1B_HUMAN
    Recommended name:
    Cornifin-B
    Protein Accession:
    P22528
    Secondary Accessions:
    • B2R5H7
    • P22529
    • P22530
    • Q5T524

    Protein attributes for SPRR1B Gene

    Size:
    89 amino acids
    Molecular mass:
    9888 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR1B Gene

Proteomics data for SPRR1B Gene at MOPED

Post-translational modifications for SPRR1B Gene

Other Protein References for SPRR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR1B Gene

Domains & Families for SPRR1B Gene

Protein Domains for SPRR1B Gene

Suggested Antigen Peptide Sequences for SPRR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22528

UniProtKB/Swiss-Prot:

SPR1B_HUMAN :
  • Belongs to the cornifin (SPRR) family.
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR1B: view

No data available for Gene Families for SPRR1B Gene

Function for SPRR1B Gene

Molecular function for SPRR1B Gene

GENATLAS Biochemistry:
small proline rich protein 1B,14kDa,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
UniProtKB/Swiss-Prot Induction:
By carcinogenic agents and by UV light. During squamous differentiation of epidermal keratinocytes.

Gene Ontology (GO) - Molecular Function for SPRR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IDA 10908733
genes like me logo Genes that share ontologies with SPRR1B: view

Phenotypes for SPRR1B Gene

genes like me logo Genes that share phenotypes with SPRR1B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPRR1B Gene

Localization for SPRR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR1B Gene COMPARTMENTS Subcellular localization image for SPRR1B gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for SPRR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPRR1B: view

Pathways & Interactions for SPRR1B Gene

SuperPathways for SPRR1B Gene

No Data Available

Interacting Proteins for SPRR1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000306461%0d%0a9606.ENSP00000222305%0d%0a
Selected Interacting proteins: P22528-SPR1B_HUMAN ENSP00000306461 for SPRR1B Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SPRR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 1627333
GO:0018149 peptide cross-linking IDA 10908733
genes like me logo Genes that share ontologies with SPRR1B: view

No data available for Pathways by source and SIGNOR curated interactions for SPRR1B Gene

Drugs & Compounds for SPRR1B Gene

(4) Drugs for SPRR1B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SPRR1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPRR1B: view

Transcripts for SPRR1B Gene

mRNA/cDNA for SPRR1B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR1B Gene

Small proline-rich protein 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR1B Gene

No ASD Table

Relevant External Links for SPRR1B Gene

GeneLoc Exon Structure for
SPRR1B
ECgene alternative splicing isoforms for
SPRR1B

Expression for SPRR1B Gene

mRNA expression in normal human tissues for SPRR1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRR1B Gene

This gene is overexpressed in Esophagus - Mucosa (x17.1), Vagina (x11.4), Cervix - Ectocervix (x11.2), and Minor Salivary Gland (x7.8).

Protein differential expression in normal tissues from HIPED for SPRR1B Gene

This gene is overexpressed in Cervix (46.7), Oral epithelium (8.6), and Skin (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRR1B Gene



SOURCE GeneReport for Unigene cluster for SPRR1B Gene Hs.1076

mRNA Expression by UniProt/SwissProt for SPRR1B Gene

P22528-SPR1B_HUMAN
Tissue specificity: Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
genes like me logo Genes that share expression patterns with SPRR1B: view

Protein tissue co-expression partners for SPRR1B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SPRR1B Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPRR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRR1B 35
  • 98.5 (n)
  • 98.88 (a)
SPRR1B 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Sprr1a 36
  • 53 (a)
ManyToMany
Species with no ortholog for SPRR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR1B Gene

ENSEMBL:
Gene Tree for SPRR1B (if available)
TreeFam:
Gene Tree for SPRR1B (if available)

Paralogs for SPRR1B Gene

Paralogs for SPRR1B Gene

(4) SIMAP similar genes for SPRR1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPRR1B: view

Variants for SPRR1B Gene

Sequence variations from dbSNP and Humsavar for SPRR1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_002164 -
VAR_002165 -
VAR_002166 -
rs3795382 - 153,032,377(+) TTGCA(C/T)CCCAC reference, missense
rs2711 -- 153,032,680(+) TTCTG(C/T)GTATG utr-variant-3-prime

Variation tolerance for SPRR1B Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRR1B Gene

HapMap Linkage Disequilibrium report
SPRR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPRR1B Gene

Disorders for SPRR1B Gene

Relevant External Links for SPRR1B

Genetic Association Database (GAD)
SPRR1B
Human Genome Epidemiology (HuGE) Navigator
SPRR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRR1B

No disorders were found for SPRR1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPRR1B Gene

Publications for SPRR1B Gene

  1. Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids. (PMID: 1438308) Marvin K.W. … Jetten A.M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 23 67
  2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3 23
  3. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. (PMID: 18172072) Li S. … McNamara N.A. (Invest. Ophthalmol. Vis. Sci. 2008) 3 23
  4. Cloning and regulation of cornifin beta, a new member of the cornifin/spr family. Suppression by retinoic acid receptor-selective retinoids. (PMID: 8631988) Austin S.J. … Jetten A.M. (J. Biol. Chem. 1996) 3 23
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for SPRR1B Gene

Sources for SPRR1B Gene

Back to Top

Content