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Aliases for SPRR1B Gene

Aliases for SPRR1B Gene

  • Small Proline-Rich Protein 1B 2 3
  • Small Proline-Rich Protein IB 3 4
  • 14.9 KDa Pancornulin 3 4
  • SPR-IB 3 4
  • Cornifin B 3
  • Cornifin-B 3
  • Cornifin 2
  • CORNIFIN 3
  • GADD33 3
  • SPRR1 3

External Ids for SPRR1B Gene

Previous HGNC Symbols for SPRR1B Gene

  • SPRR1

Previous GeneCards Identifiers for SPRR1B Gene

  • GC01P150819
  • GC01P148786
  • GC01P149778
  • GC01P150220
  • GC01P149816
  • GC01P151270
  • GC01P153003
  • GC01P124366

Summaries for SPRR1B Gene

GeneCards Summary for SPRR1B Gene

SPRR1B (Small Proline-Rich Protein 1B) is a Protein Coding gene. Diseases associated with SPRR1B include epidermolytic hyperkeratosis. GO annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is SPRR3.

UniProtKB/Swiss-Prot for SPRR1B Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage

Gene Wiki entry for SPRR1B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR1B Gene

Genomics for SPRR1B Gene

Regulatory Elements for SPRR1B Gene

Genomic Location for SPRR1B Gene

Start:
153,031,202 bp from pter
End:
153,032,900 bp from pter
Size:
1,699 bases
Orientation:
Plus strand

Genomic View for SPRR1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR1B Gene

Proteins for SPRR1B Gene

  • Protein details for SPRR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22528-SPR1B_HUMAN
    Recommended name:
    Cornifin-B
    Protein Accession:
    P22528
    Secondary Accessions:
    • B2R5H7
    • P22529
    • P22530
    • Q5T524

    Protein attributes for SPRR1B Gene

    Size:
    89 amino acids
    Molecular mass:
    9888 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR1B Gene

Proteomics data for SPRR1B Gene at MOPED

Post-translational modifications for SPRR1B Gene

Other Protein References for SPRR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRR1B Gene

Domains for SPRR1B Gene

Protein Domains for SPRR1B Gene

Suggested Antigen Peptide Sequences for SPRR1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22528

UniProtKB/Swiss-Prot:

SPR1B_HUMAN :
  • P22528
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR1B: view

No data available for Gene Families for SPRR1B Gene

Function for SPRR1B Gene

Molecular function for SPRR1B Gene

GENATLAS Biochemistry:
small proline rich protein 1B,14kDa,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage
UniProtKB/Swiss-Prot Induction:
By carcinogenic agents and by UV light. During squamous differentiation of epidermal keratinocytes

Gene Ontology (GO) - Molecular Function for SPRR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IDA 10908733
GO:0030674 protein binding, bridging IDA 10908733
genes like me logo Genes that share ontologies with SPRR1B: view

Phenotypes for SPRR1B Gene

GenomeRNAi human phenotypes for SPRR1B:
genes like me logo Genes that share phenotypes with SPRR1B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPRR1B Gene

Localization for SPRR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR1B Gene COMPARTMENTS Subcellular localization image for SPRR1B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for SPRR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 10908733
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SPRR1B: view

Pathways for SPRR1B Gene

SuperPathways for SPRR1B Gene

No Data Available

Interacting Proteins for SPRR1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000306461%0d%0a9606.ENSP00000222305%0d%0a
Selected Interacting proteins: ENSP00000306461 P22528-SPR1B_HUMAN for SPRR1B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SPRR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 1627333
GO:0018149 peptide cross-linking IDA 10908733
GO:0030216 keratinocyte differentiation IDA 10908733
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with SPRR1B: view

No data available for Pathways by source for SPRR1B Gene

Compounds for SPRR1B Gene

(5) Novoseek inferred chemical compound relationships for SPRR1B Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 57.6 8
proline 50.5 3
diethylstilbestrol 43.7 1
dexamethasone 5.48 1
calcium 0 1
genes like me logo Genes that share compounds with SPRR1B: view

Transcripts for SPRR1B Gene

mRNA/cDNA for SPRR1B Gene

(82) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR1B Gene

Small proline-rich protein 1B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR1B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR1B Gene

No ASD Table

Relevant External Links for SPRR1B Gene

GeneLoc Exon Structure for
SPRR1B
ECgene alternative splicing isoforms for
SPRR1B

Expression for SPRR1B Gene

mRNA expression in normal human tissues for SPRR1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRR1B Gene

This gene is overexpressed in Esophagus - Mucosa (17.1), Vagina (11.4), Cervix - Ectocervix (11.2), and Minor Salivary Gland (7.8).

Protein differential expression in normal tissues for SPRR1B Gene

This gene is overexpressed in Cervix (46.7), Oral epithelium (8.6), and Skin (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRR1B Gene

SOURCE GeneReport for Unigene cluster for SPRR1B Gene Hs.1076

mRNA Expression by UniProt/SwissProt for SPRR1B Gene

P22528-SPR1B_HUMAN
Tissue specificity: Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea
genes like me logo Genes that share expressions with SPRR1B: view

Expression partners for SPRR1B Gene

In Situ Assay Products

Orthologs for SPRR1B Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPRR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRR1B 35
  • 98.5 (n)
  • 98.88 (a)
SPRR1B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sprr1b 16
Sprr1a 36
  • 53 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
Species with no ortholog for SPRR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR1B Gene

ENSEMBL:
Gene Tree for SPRR1B (if available)
TreeFam:
Gene Tree for SPRR1B (if available)

Paralogs for SPRR1B Gene

Paralogs for SPRR1B Gene

Selected SIMAP similar genes for SPRR1B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPRR1B: view

Variants for SPRR1B Gene

Sequence variations from dbSNP and Humsavar for SPRR1B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2711 -- 153,032,680(+) TTCTG(C/T)GTATG utr-variant-3-prime
rs12195 -- 153,032,507(+) GTGCC(C/T)GAGCC reference, synonymous-codon
rs370162 -- 153,033,012(+) CTGAT(A/G)CTCAC downstream-variant-500B
rs423692 -- 153,033,205(+) CCTGA(G/T)TGCCT downstream-variant-500B
rs436466 -- 153,033,120(-) CCCTT(C/G/T)TCCAG downstream-variant-500B

Relevant External Links for SPRR1B Gene

HapMap Linkage Disequilibrium report
SPRR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPRR1B Gene

Disorders for SPRR1B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SPRR1B Gene in MalaCards »

(1) Diseases for SPRR1B Gene including...

(2) University of Copenhagen DISEASES for SPRR1B Gene

(6) Novoseek inferred disease relationships for SPRR1B Gene

Disease -log(P) Hits PubMed IDs
metaplasia 54.6 4
cervical intraepithelial neoplasia 36.4 1
premalignant 30 1
carcinoma squamous cell 21 1
skin diseases 16.3 1

Relevant External Links for SPRR1B

Genetic Association Database (GAD)
SPRR1B
Human Genome Epidemiology (HuGE) Navigator
SPRR1B
genes like me logo Genes that share disorders with SPRR1B: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SPRR1B Gene

Publications for SPRR1B Gene

  1. Cornifin, a cross-linked envelope precursor in keratinocytes that is down-regulated by retinoids. (PMID: 1438308) Marvin K.W. … Jetten A.M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 3 23
  2. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3 23
  3. Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes. (PMID: 3133554) Kartasova T. … van de Putte P. (Mol. Cell. Biol. 1988) 3 4
  4. The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation. (PMID: 7829876) Greco M.A. … Kvedar J.C. (J. Invest. Dermatol. 1995) 3 4
  5. Isolation and characterization of the human spr1 gene and its regulation of expression by phorbol ester and cyclic AMP. (PMID: 8388378) An G. … Wu R. (J. Biol. Chem. 1993) 3 4

Products for SPRR1B Gene

Sources for SPRR1B Gene

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