Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPRR1A Gene

Aliases for SPRR1A Gene

  • Small Proline-Rich Protein 1A 2 3
  • Small Proline-Rich Protein IA 3 4
  • 19 KDa Pancornulin 3 4
  • SPR-IA 3 4
  • SPRK 3 4
  • Cornifin A 3
  • Cornifin-A 3

External Ids for SPRR1A Gene

Previous GeneCards Identifiers for SPRR1A Gene

  • GC01P150773
  • GC01P148739
  • GC01P149731
  • GC01P150174
  • GC01P149769
  • GC01P151223
  • GC01P152956
  • GC01P124319

Summaries for SPRR1A Gene

GeneCards Summary for SPRR1A Gene

SPRR1A (Small Proline-Rich Protein 1A) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity and protein binding, bridging. An important paralog of this gene is SPRR3.

UniProtKB/Swiss-Prot for SPRR1A Gene

  • Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane

Gene Wiki entry for SPRR1A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRR1A Gene

Genomics for SPRR1A Gene

Regulatory Elements for SPRR1A Gene

Genomic Location for SPRR1A Gene

Start:
152,984,088 bp from pter
End:
152,985,814 bp from pter
Size:
1,727 bases
Orientation:
Plus strand

Genomic View for SPRR1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRR1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRR1A Gene

Proteins for SPRR1A Gene

  • Protein details for SPRR1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35321-SPR1A_HUMAN
    Recommended name:
    Cornifin-A
    Protein Accession:
    P35321
    Secondary Accessions:
    • B1AN47
    • D3DV31
    • Q2M303
    • Q9UDG4

    Protein attributes for SPRR1A Gene

    Size:
    89 amino acids
    Molecular mass:
    9877 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPRR1A Gene

Proteomics data for SPRR1A Gene at MOPED

Post-translational modifications for SPRR1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPRR1A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPRR1A Gene

Domains for SPRR1A Gene

Protein Domains for SPRR1A Gene

Suggested Antigen Peptide Sequences for SPRR1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35321

UniProtKB/Swiss-Prot:

SPR1A_HUMAN :
  • P35321
Family:
  • Belongs to the cornifin (SPRR) family.
genes like me logo Genes that share domains with SPRR1A: view

No data available for Gene Families for SPRR1A Gene

Function for SPRR1A Gene

Molecular function for SPRR1A Gene

GENATLAS Biochemistry:
small proline rich protein 1A,precursor of cornified cell envelope,cornifin,clustered in the epidermal differentiation complex (EDC)
UniProtKB/Swiss-Prot Function:
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane
UniProtKB/Swiss-Prot Induction:
During squamous differentiation of epidermal keratinocytes

Gene Ontology (GO) - Molecular Function for SPRR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IDA 10908733
GO:0005515 protein binding IPI 10066784
GO:0030674 protein binding, bridging IDA 10908733
genes like me logo Genes that share ontologies with SPRR1A: view

Phenotypes for SPRR1A Gene

GenomeRNAi human phenotypes for SPRR1A:
genes like me logo Genes that share phenotypes with SPRR1A: view

Animal Model Products

miRNA for SPRR1A Gene

miRTarBase miRNAs that target SPRR1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPRR1A Gene

Localization for SPRR1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRR1A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRR1A Gene COMPARTMENTS Subcellular localization image for SPRR1A gene
Compartment Confidence
cytoskeleton 5
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for SPRR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001533 cornified envelope IDA 10908733
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPRR1A: view

Pathways for SPRR1A Gene

SuperPathways for SPRR1A Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat
    • Nephrotoxicity in human,mouse,rat

Interacting Proteins for SPRR1A Gene

Selected Interacting proteins: P35321-SPR1A_HUMAN for SPRR1A Gene via I2D

Symbol External ID(s) Details
ACTA1

Gene Ontology (GO) - Biological Process for SPRR1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 8325635
GO:0018149 peptide cross-linking IDA 10908733
GO:0030216 keratinocyte differentiation IDA 10908733
GO:0031424 keratinization IEA --
genes like me logo Genes that share ontologies with SPRR1A: view

No data available for Pathways by source for SPRR1A Gene

Transcripts for SPRR1A Gene

mRNA/cDNA for SPRR1A Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(114) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRR1A Gene

Small proline-rich protein 1A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR1A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRR1A Gene

No ASD Table

Relevant External Links for SPRR1A Gene

GeneLoc Exon Structure for
SPRR1A
ECgene alternative splicing isoforms for
SPRR1A

Expression for SPRR1A Gene

mRNA expression in normal human tissues for SPRR1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRR1A Gene

This gene is overexpressed in Esophagus - Mucosa (24.5), Vagina (11.7), Cervix - Ectocervix (9.5), and Minor Salivary Gland (4.8).

Protein differential expression in normal tissues for SPRR1A Gene

This gene is overexpressed in Cervix (47.6), Esophagus (7.1), and Oral epithelium (6.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPRR1A Gene

SOURCE GeneReport for Unigene cluster for SPRR1A Gene Hs.46320

genes like me logo Genes that share expressions with SPRR1A: view

Expression partners for SPRR1A Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPRR1A Gene

Orthologs for SPRR1A Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPRR1A Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Sprr1a 35
  • 79.39 (n)
  • 80 (a)
Sprr1a 16
Sprr1b 36
  • 46 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Sprr1a 35
  • 80.81 (n)
  • 86.87 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SPRR1A 36
  • 100 (a)
OneToOne
Species with no ortholog for SPRR1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRR1A Gene

ENSEMBL:
Gene Tree for SPRR1A (if available)
TreeFam:
Gene Tree for SPRR1A (if available)

Paralogs for SPRR1A Gene

Paralogs for SPRR1A Gene

Selected SIMAP similar genes for SPRR1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPRR1A: view

Variants for SPRR1A Gene

Sequence variations from dbSNP and Humsavar for SPRR1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1129654 -- 152,985,762(-) GATCC(C/T)TCCCC utr-variant-3-prime
rs1129655 -- 152,985,791(+) CTTCC(C/T)TCAAT utr-variant-3-prime
rs1415962 -- 152,986,255(-) CATGT(A/G)TTGGG downstream-variant-500B
rs1415964 -- 152,982,609(-) GAGTG(A/G)CAGCG upstream-variant-2KB
rs1611753 -- 152,983,905(+) CCAGC(C/T)AGTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPRR1A Gene

Variant ID Type Subtype PubMed ID
nsv831592 CNV Gain 17160897
nsv508038 CNV Loss 20534489

Relevant External Links for SPRR1A Gene

HapMap Linkage Disequilibrium report
SPRR1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRR1A Gene

Disorders for SPRR1A Gene

Relevant External Links for SPRR1A

Genetic Association Database (GAD)
SPRR1A
Human Genome Epidemiology (HuGE) Navigator
SPRR1A

No disorders were found for SPRR1A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPRR1A Gene

Publications for SPRR1A Gene

  1. Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins. (PMID: 8325635) Gibbs S. … Backendorf C. (Genomics 1993) 2 3 4
  2. Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients. (PMID: 19601998) Stemmler S. … Hoffjan S. (Int. J. Immunogenet. 2009) 3 48
  3. Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth. (PMID: 11850458) Bonilla I.E. … Strittmatter S.M. (J. Neurosci. 2002) 3 23
  4. S100A11, S100A10, annexin I, desmosomal proteins, small proline-rich proteins, plasminogen activator inhibitor-2, and involucrin are components of the cornified envelope of cultured human epidermal keratinocytes. (PMID: 9115270) Robinson N.A. … Eckert R.L. (J. Biol. Chem. 1997) 3 23
  5. Structure and organization of the genes encoding mouse small proline-rich proteins, mSPRR1A and 1B. (PMID: 9931436) Reddy S.P. … Wu R. (Gene 1998) 3 23

Products for SPRR1A Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat
    • Nephrotoxicity in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate SPRR1A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SPRR1A
    • Block miRNA regulation of SPRR1A using miScript Target Protectors

    Sources for SPRR1A Gene

    Back to Top

    Content