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Aliases for SPRN Gene

Aliases for SPRN Gene

  • Shadow Of Prion Protein Homolog (Zebrafish) 2 3 5
  • Hypothetical Protein BC004409 2 3
  • Protein Shadoo 3 4
  • SHO 3 4
  • BA108K14.1 3
  • SHADOO 3

External Ids for SPRN Gene

Previous GeneCards Identifiers for SPRN Gene

  • GC10U900602
  • GC10M135085
  • GC10M135234
  • GC10M128777

Summaries for SPRN Gene

GeneCards Summary for SPRN Gene

SPRN (Shadow Of Prion Protein Homolog (Zebrafish)) is a Protein Coding gene. Diseases associated with SPRN include paranoid personality disorder and avoidant personality disorder. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SPRN Gene

  • Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRN Gene

Genomics for SPRN Gene

Regulatory Elements for SPRN Gene

Enhancers for SPRN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPRN on UCSC Golden Path with GeneCards custom track

Genomic Location for SPRN Gene

133,420,666 bp from pter
133,424,617 bp from pter
3,952 bases
Minus strand

Genomic View for SPRN Gene

Genes around SPRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRN Gene

Proteins for SPRN Gene

  • Protein details for SPRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Shadow of prion protein
    Protein Accession:

    Protein attributes for SPRN Gene

    151 amino acids
    Molecular mass:
    14522 Da
    Quaternary structure:
    No Data Available
    • Shadoo means shadow in Japanese.

neXtProt entry for SPRN Gene

Proteomics data for SPRN Gene at MOPED

Post-translational modifications for SPRN Gene

Other Protein References for SPRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRN Gene

Domains & Families for SPRN Gene

Protein Domains for SPRN Gene


Suggested Antigen Peptide Sequences for SPRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPRN family.
  • Belongs to the SPRN family.
genes like me logo Genes that share domains with SPRN: view

No data available for Gene Families for SPRN Gene

Function for SPRN Gene

Molecular function for SPRN Gene

UniProtKB/Swiss-Prot Function:
Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).
genes like me logo Genes that share phenotypes with SPRN: view

Animal Models for SPRN Gene

MGI Knock Outs for SPRN:

Animal Model Products

miRNA for SPRN Gene

miRTarBase miRNAs that target SPRN

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRN Gene

Localization for SPRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRN Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for SPRN Gene COMPARTMENTS Subcellular localization image for SPRN gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SPRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0031225 anchored component of membrane IEA --
GO:0031982 vesicle IEA --
genes like me logo Genes that share ontologies with SPRN: view

Pathways & Interactions for SPRN Gene

SuperPathways for SPRN Gene

No Data Available

Interacting Proteins for SPRN Gene

Selected Interacting proteins: Q5BIV9-SPRN_HUMAN for SPRN Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPRN Gene


No data available for Pathways by source and SIGNOR curated interactions for SPRN Gene

Drugs & Compounds for SPRN Gene

No Compound Related Data Available

Transcripts for SPRN Gene

mRNA/cDNA for SPRN Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRN Gene

Shadow of prion protein homolog (zebrafish):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRN Gene

No ASD Table

Relevant External Links for SPRN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRN Gene

mRNA expression in normal human tissues for SPRN Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRN Gene

SOURCE GeneReport for Unigene cluster for SPRN Gene Hs.64968

mRNA Expression by UniProt/SwissProt for SPRN Gene

Tissue specificity: Mainly expressed in brain. In brain, it is expressed in hippocampus.
genes like me logo Genes that share expression patterns with SPRN: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for SPRN Gene

Orthologs for SPRN Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPRN Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPRN 35
  • 74.13 (n)
  • 69.93 (a)
  • 81 (a)
(Canis familiaris)
Mammalia LOC100855950 35
  • 82.17 (n)
  • 79.84 (a)
  • 83 (a)
(Mus musculus)
Mammalia Sprn 35
  • 76.42 (n)
  • 76.87 (a)
Sprn 16
Sprn 36
  • 82 (a)
(Pan troglodytes)
Mammalia SPRN 35
  • 98.9 (n)
  • 98.68 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Sprn 35
  • 75.06 (n)
  • 74.83 (a)
Species with no ortholog for SPRN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRN Gene

Gene Tree for SPRN (if available)
Gene Tree for SPRN (if available)

Paralogs for SPRN Gene

No data available for Paralogs for SPRN Gene

Variants for SPRN Gene

Sequence variations from dbSNP and Humsavar for SPRN Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2492666 - 133,423,662(-) CGCAA(C/T)GTGCT reference, missense
rs3087638 -- 133,422,438(-) CTTTG(A/G)ACTTC utr-variant-3-prime
rs3197116 -- 133,422,323(-) ACGCA(C/T)TTCCC utr-variant-3-prime
rs4077586 -- 133,423,499(+) GAGGA(A/G)CCCGG reference, synonymous-codon
rs2297033 -- 133,421,344(+) TGGAA(C/T)ATTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPRN Gene

Variant ID Type Subtype PubMed ID
nsv528260 CNV Loss 19592680
dgv880n71 CNV Loss 21882294
dgv2e196 CNV Duplication 17116639
essv9566 CNV CNV 17122850
nsv428243 CNV Gain 18775914
dgv3e196 CNV Duplication 17116639
esv2750853 CNV Gain 17911159
dgv889n71 CNV Loss 21882294
nsv470981 CNV Gain 18288195
nsv896317 CNV Loss 21882294
dgv35e55 CNV Gain 17911159
dgv329e1 CNV Complex 17122850
nsv7631 CNV Loss 18451855
dgv123n27 CNV Gain 19166990
nsv832041 CNV Gain 17160897
nsv896318 CNV Gain 21882294
dgv890n71 CNV Gain 21882294
nsv517180 CNV Gain+Loss 19592680
dgv124n27 CNV Gain 19166990
dgv125n27 CNV Gain 19166990
dgv891n71 CNV Loss 21882294
nsv896321 CNV Gain 21882294
nsv469597 CNV Gain 16826518
nsv514545 CNV Gain 21397061
dgv892n71 CNV Gain 21882294
dgv893n71 CNV Gain+Loss 21882294
esv33719 CNV Gain 17666407
esv28562 CNV Gain+Loss 19812545

Variation tolerance for SPRN Gene

Gene Damage Index Score: 9.83; 89.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRN Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRN Gene

Disorders for SPRN Gene

MalaCards: The human disease database

(6) MalaCards diseases for SPRN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
paranoid personality disorder
avoidant personality disorder
  • anxious personality disorder
prion disease
  • prion disease pathway
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
- elite association - COSMIC cancer census association via MalaCards
Search SPRN in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPRN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRN Gene

Publications for SPRN Gene

  1. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. (PMID: 14527721) Premzl M. … Gready J.E. (Gene 2003) 2 3 4 23 67
  2. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. (PMID: 18805828) Beck J.A. … Mead S. (J. Med. Genet. 2008) 3 23
  3. Evolution of vertebrate genes related to prion and Shadoo proteins- Clues from comparative genomic analysis. (PMID: 15342797) Premzl M. … Marshall Graves J.A. (Mol. Biol. Evol. 2004) 3 23
  4. Disruption of Glycosylation Enhances Ubiquitin-Mediated Proteasomal Degradation of Shadoo in Scrapie-Infected Rodents and Cultured Cells. (PMID: 24390475) Zhang J. … Dong X.P. (Mol. Neurobiol. 2014) 3
  5. Conserved stress-protective activity between prion protein and Shadoo. (PMID: 21257747) Sakthivelu V. … Tatzelt J. (J. Biol. Chem. 2011) 3

Products for SPRN Gene

Sources for SPRN Gene