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SPRN Gene

protein-coding   GIFtS: 43
GCID: GC10M135234

Shadow Of Prion Protein Homolog (Zebrafish)

  See SPRN-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Shadow Of Prion Protein Homolog (Zebrafish)1 2     SHADOO2 5
SHO2 3 5     bA108K14.12
Hypothetical Protein BC0044091 2     Shadow Of Prion Protein2
Protein Shadoo2 3     

External Ids:    HGNC: 168711   Entrez Gene: 5035422   Ensembl: ENSG000002037727   OMIM: 6104475   UniProtKB: Q5BIV93   

Export aliases for SPRN gene to outside databases

Previous GC identifers: GC10U900602 GC10M135085 GC10M128777


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPRN Gene:
SPRN (shadow of prion protein homolog (zebrafish)) is a protein-coding gene. Diseases associated with SPRN include variant creutzfeldt-jakob disease.

UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9
Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the
biological actions of normal and abnormal PrP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPRN gene promoter:
         GR   AP-1   GR-beta   MIF-1   Nkx5-1   Max   GR-alpha   c-Myc   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRN promoter sequence
   Search Chromatin IP Primers for SPRN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

SPRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135234:  view genomic region     (about GC identifiers)

Start:
135,234,170 bp from pter      End:
135,382,916 bp from pter
Size:
148,747 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9 (See protein sequence)
Recommended Name: Shadow of prion protein precursor  
Size: 151 amino acids; 14522 Da
Miscellaneous: 'Shadoo' means 'shadow' in Japanese

Explore the universe of human proteins at neXtProt for SPRN: NX_Q5BIV9

Explore proteomics data for SPRN at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn111

  • See SPRN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001012526.2  
    ENSEMBL proteins: 
     ENSP00000433712   ENSP00000443979  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q5BIV9

    UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9
    Similarity: Belongs to the SPRN family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRN_HUMAN, Q5BIV9
    Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the
    biological actions of normal and abnormal PrP (By similarity)

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sprn):

     behavior/neurological  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with SPRN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Sprntm1Geno for SPRN

       genOway: Develop your customized and physiologically relevant rodent model for SPRN

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPRN_HUMAN, Q5BIV9: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with SPRN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRN
    Interactions:

        Search GeneGlobe Interaction Network for SPRN

    1 Interacting protein for SPRN (Q5BIV93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STRN4Q9NRL33I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRN



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPRN gene: 
    NM_001012508.3  

    Unigene Cluster for SPRN:

    Shadow of prion protein homolog (zebrafish)
    Hs.64968  [show with all ESTs]
    Unigene Representative Sequence: NM_001012508
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414069(uc001lnf.4) ENST00000541506
    miRNA
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    Additional mRNA sequence: BC040198.1 

    2 DOTS entries:

    DT.100811551  DT.87016111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPRN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGGGCA
    SPRN Expression
    About this image


    SPRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
    SPRN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.64968

    UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9
    Tissue specificity: Mainly expressed in brain. In brain, it is expressed in hippocampus

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for SPRN gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sprn1 , 5 shadow of prion protein1, 5 76.42(n)1
    76.87(a)1
      7 (85.17 cM)5
    2125181  NM_183147.21  NP_898970.11 
     1401506285 


    ENSEMBL Gene Tree for SPRN (if available)
    TreeFam Gene Tree for SPRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPRN (see all 3101)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71004971,2
    C,F,A--135234736(+) GCATCG/ATGCCA 1 -- ut31 ese31Minor allele frequency- A:0.04WA 118
    rs79046261,2
    C,F,A,H--135234761(+) TGGGGC/TAGGAA 1 -- ut31 ese35Minor allele frequency- T:0.01NS EA WA 530
    rs557775111,2
    C,F--135234839(+) CATCAT/CAACTG 1 -- ut312Minor allele frequency- C:0.02NA EU 713
    rs22970331,2
    C,F,A--135234848(+) TGGAAC/TATTCC 1 -- ut31 ese38Minor allele frequency- T:0.35EA WA NA CSA EU 2457
    rs1909866621,2
    --135234868(+) CAGTGC/TTGTGG 1 -- ut310--------
    rs1455901771,2
    --135234881(+) TGTGAA/GGGTCT 1 -- ut310--------
    rs1825946891,2
    C--135234919(+) GGCATC/GTGCAA 1 -- ut310--------
    rs1477132941,2
    C--135234939(+) GGCTCC/TGGTGG 1 -- ut310--------
    rs1881064981,2
    --135235014(+) CTCTGC/TCTATG 1 -- ut310--------
    rs1425065911,2
    --135235017(+) TGCCTA/GTGAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SPRN (135234170 - 135382916 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPRN (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    dgv891n71CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv528260CNV Loss19592680
    dgv889n71CNV Loss21882294
    nsv7631CNV Loss18451855
    nsv896317CNV Loss21882294
    dgv35e55CNV Gain17911159
    nsv428243CNV Gain18775914

    Human Gene Mutation Database (HGMD): SPRN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRN
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610447    OMIM disorders: --

    1 disease for SPRN:    
    About MalaCards
    variant creutzfeldt-jakob disease


    Find genes that share disorders with SPRN           About GenesLikeMe

    Genetic Association Database (GAD): SPRN
    Human Genome Epidemiology (HuGE) Navigator: SPRN (5 documents)

    Export disorders for SPRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPRN gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SPRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. (PubMed id 14527721)1, 2, 3, 9 Premzl M.... Gready J.E. (Gene 2003)
    2. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. (PubMed id 18805828)1, 4, 9 Beck J.A....Mead S. (J. Med. Genet. 2008)
    3. Evolution of vertebrate genes related to prion and Shadoo proteins- Clues from comparative genomic analysis. (PubMed id 15342797)1, 2, 9 Premzl M....Marshall Graves J.A. (Mol. Biol. Evol. 2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Conserved stress-protective activity between prion protein and Shadoo. (PubMed id 21257747)1 Sakthivelu V....Tatzelt J. (J. Biol. Chem. 2011)
    7. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    8. A novel solid phase technology for high-throughput gene synthesis. (PubMed id 18778261)1 Van den Brulle J....Schwer H. (BioTechniques 2008)
    9. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (BMC Med. Genet. 2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 503542 HGNC: 16871 Ensembl:ENSG00000203772 euGenes: HUgn503542 ECgene: SPRN
    H-InvDB: SPRN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPRN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPRN gene:
    Search GeneIP for patents involving SPRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Block miRNA regulation of human, mouse, rat SPRN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPRN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRN Predesigned siRNA for gene silencing in human, mouse, rat SPRN
     QuantiFast Probe-based Assays in human, mouse, rat SPRN QuantiTect SYBR Green Assays in human, mouse, rat SPRN
     Custom PCR Arrays for SPRN Search Chromatin IP Primers for SPRN
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat SPRN Search GeneGlobe Interaction Network for SPRN
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     Search for Antibodies & Assays

     Search Tocris compounds for SPRN
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for SPRN at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SPRN
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     Browse ESI BIO Cell Lines and PureStem Progenitors for SPRN
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     SwitchGear 3'UTR luciferase reporter plasmids for SPRN
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     Search ThermoFisher Antibodies for SPRN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRN
     Browse compounds at ApexBio
     Search Addgene for plasmids for SPRN
      Search eBioscience for proteins for SPRN
      Search eBioscience for elisas for SPRN
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SPRN
     antibodies-online antibodies for SPRN (24 products)
     antibodies-online kits for SPRN (11 products)
     antibodies-online peptides for SPRN
     antibodies-online proteins for SPRN (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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