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Aliases for SPRN Gene

Aliases for SPRN Gene

  • Shadow Of Prion Protein Homolog (Zebrafish) 2 3 5
  • Hypothetical Protein BC004409 2 3
  • Protein Shadoo 3 4
  • SHO 3 4
  • Shadow Of Prion Protein 3
  • BA108K14.1 3
  • SHADOO 3

External Ids for SPRN Gene

Previous GeneCards Identifiers for SPRN Gene

  • GC10U900602
  • GC10M135085
  • GC10M135234
  • GC10M128777

Summaries for SPRN Gene

GeneCards Summary for SPRN Gene

SPRN (Shadow Of Prion Protein Homolog (Zebrafish)) is a Protein Coding gene. Diseases associated with SPRN include Prion Disease and Paranoid Personality Disorder. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for SPRN Gene

  • Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRN Gene

Genomics for SPRN Gene

Regulatory Elements for SPRN Gene

Enhancers for SPRN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F133393 1.1 ENCODE 0.3 +30.0 29962 2.4 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SCART1 ENSG00000235245 OR6L1P RPL23AP60 TUBGCP2 MIR202HG PAOX MTG1 SPRN
GH10F133400 0.4 ENCODE 0.3 +23.4 23444 1.5 JUNB STAT3 SCART1 MTG1 SPRN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPRN on UCSC Golden Path with GeneCards custom track

Promoters for SPRN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001765563 517 1401 POLR2A EZH2

Genomic Location for SPRN Gene

Chromosome:
10
Start:
133,420,666 bp from pter
End:
133,424,617 bp from pter
Size:
3,952 bases
Orientation:
Minus strand

Genomic View for SPRN Gene

Genes around SPRN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRN Gene

Proteins for SPRN Gene

  • Protein details for SPRN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BIV9-SPRN_HUMAN
    Recommended name:
    Shadow of prion protein
    Protein Accession:
    Q5BIV9

    Protein attributes for SPRN Gene

    Size:
    151 amino acids
    Molecular mass:
    14522 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Shadoo means shadow in Japanese.

neXtProt entry for SPRN Gene

Post-translational modifications for SPRN Gene

Other Protein References for SPRN Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRN Gene

Domains & Families for SPRN Gene

Protein Domains for SPRN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPRN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5BIV9

UniProtKB/Swiss-Prot:

SPRN_HUMAN :
  • Belongs to the SPRN family.
Family:
  • Belongs to the SPRN family.
genes like me logo Genes that share domains with SPRN: view

No data available for Gene Families for SPRN Gene

Function for SPRN Gene

Molecular function for SPRN Gene

UniProtKB/Swiss-Prot Function:
Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity).

Gene Ontology (GO) - Molecular Function for SPRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with SPRN: view
genes like me logo Genes that share phenotypes with SPRN: view

Animal Models for SPRN Gene

MGI Knock Outs for SPRN:

Animal Model Products

miRNA for SPRN Gene

miRTarBase miRNAs that target SPRN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPRN Gene

Localization for SPRN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRN Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRN gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SPRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPRN: view

Pathways & Interactions for SPRN Gene

genes like me logo Genes that share pathways with SPRN: view

Interacting Proteins for SPRN Gene

Selected Interacting proteins: Q5BIV9-SPRN_HUMAN for SPRN Gene via IID

Symbol External ID(s) Details
STRN4

Gene Ontology (GO) - Biological Process for SPRN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
genes like me logo Genes that share ontologies with SPRN: view

No data available for SIGNOR curated interactions for SPRN Gene

Transcripts for SPRN Gene

mRNA/cDNA for SPRN Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRN Gene

Shadow of prion protein homolog (zebrafish):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRN Gene

No ASD Table

Relevant External Links for SPRN Gene

GeneLoc Exon Structure for
SPRN
ECgene alternative splicing isoforms for
SPRN

Expression for SPRN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRN Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPRN Gene



NURSA nuclear receptor signaling pathways regulating expression of SPRN Gene:

SPRN

SOURCE GeneReport for Unigene cluster for SPRN Gene:

Hs.64968

mRNA Expression by UniProt/SwissProt for SPRN Gene:

Q5BIV9-SPRN_HUMAN
Tissue specificity: Mainly expressed in brain. In brain, it is expressed in hippocampus.
genes like me logo Genes that share expression patterns with SPRN: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for SPRN Gene

Orthologs for SPRN Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPRN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRN 34 35
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia SPRN 35
  • 83 (a)
OneToOne
LOC100855950 34
  • 82.17 (n)
mouse
(Mus musculus)
Mammalia Sprn 34 16 35
  • 76.42 (n)
rat
(Rattus norvegicus)
Mammalia Sprn 34
  • 75.06 (n)
cow
(Bos Taurus)
Mammalia SPRN 34 35
  • 74.13 (n)
Species where no ortholog for SPRN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRN Gene

ENSEMBL:
Gene Tree for SPRN (if available)
TreeFam:
Gene Tree for SPRN (if available)

Paralogs for SPRN Gene

No data available for Paralogs for SPRN Gene

Variants for SPRN Gene

Sequence variations from dbSNP and Humsavar for SPRN Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1052582 -- 133,420,336(+) CAGGG(C/G)CCAAG intron-variant, utr-variant-3-prime
rs1056521 -- 133,422,386(-) GGCAC(A/G)GCAAC utr-variant-3-prime
rs10776681 -- 133,422,185(+) TGGCC(A/C)CCTGC utr-variant-3-prime
rs10857714 -- 133,421,866(+) CTGTC(A/C)CCAGG utr-variant-3-prime
rs11101746 -- 133,423,859(+) TTAAC(C/T)TCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRN Gene

Variant ID Type Subtype PubMed ID
dgv1000n100 CNV gain 25217958
dgv1001n100 CNV gain 25217958
dgv123n27 CNV gain 19166990
dgv124n27 CNV gain 19166990
dgv125n27 CNV gain 19166990
dgv1486n54 CNV gain 21841781
dgv1487n54 CNV gain 21841781
dgv1488n54 CNV gain 21841781
dgv1489n54 CNV gain 21841781
dgv2e196 CNV duplication 17116639
dgv304e212 CNV gain 25503493
dgv35e55 CNV gain 17911159
dgv39n111 CNV duplication 26073780
dgv3e196 CNV duplication 17116639
dgv999n100 CNV gain 25217958
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv2760130 CNV gain+loss 21179565
esv2764146 CNV gain+loss 21179565
esv28562 CNV gain+loss 19812545
esv33719 CNV gain 17666407
esv3579239 CNV loss 25503493
nsv1043323 CNV gain 25217958
nsv1052033 CNV gain 25217958
nsv1052904 CNV gain 25217958
nsv428243 CNV gain 18775914
nsv469597 CNV gain 16826518
nsv470981 CNV gain 18288195
nsv514545 CNV gain 21397061
nsv517180 CNV gain+loss 19592680
nsv528260 CNV loss 19592680
nsv552589 CNV gain 21841781
nsv7631 CNV deletion 18451855
nsv832041 CNV gain 17160897
nsv952708 CNV deletion 24416366

Variation tolerance for SPRN Gene

Gene Damage Index Score: 9.83; 89.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRN Gene

Human Gene Mutation Database (HGMD)
SPRN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPRN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRN Gene

Disorders for SPRN Gene

MalaCards: The human disease database

(6) MalaCards diseases for SPRN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prion disease
  • prion disease pathway
paranoid personality disorder
avoidant personality disorder
  • anxious personality disorder
scrapie
creutzfeldt-jakob disease
  • creutzfeldt-jakob disease, variant
- elite association - COSMIC cancer census association via MalaCards
Search SPRN in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPRN

Genetic Association Database (GAD)
SPRN
Human Genome Epidemiology (HuGE) Navigator
SPRN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRN
genes like me logo Genes that share disorders with SPRN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRN Gene

Publications for SPRN Gene

  1. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. (PMID: 14527721) Premzl M. … Gready J.E. (Gene 2003) 2 3 4 22 64
  2. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. (PMID: 18805828) Beck J.A. … Mead S. (J. Med. Genet. 2008) 3 22 46 64
  3. Evolution of vertebrate genes related to prion and Shadoo proteins- Clues from comparative genomic analysis. (PMID: 15342797) Premzl M. … Marshall Graves J.A. (Mol. Biol. Evol. 2004) 3 4 22 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for SPRN Gene

Sources for SPRN Gene

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