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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPRN Gene

protein-coding   GIFtS: 44
GCID: GC10M135234

Shadow Of Prion Protein Homolog (Zebrafish)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Shadow Of Prion Protein Homolog (Zebrafish)1 2     SHADOO2 5
SHO2 3 5     bA108K14.12
Hypothetical Protein BC0044091 2     Shadow Of Prion Protein2
Protein Shadoo2 3     

External Ids:    HGNC: 168711   Entrez Gene: 5035422   Ensembl: ENSG000002037727   OMIM: 6104475   UniProtKB: Q5BIV93   

Export aliases for SPRN gene to outside databases

Previous GC identifers: GC10U900602 GC10M135085 GC10M128777


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPRN Gene: 
SPRN (shadow of prion protein homolog (zebrafish)) is a protein-coding gene. Diseases associated with SPRN include variant creutzfeldt-jakob disease, and prion disease.

UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9
Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the
biological actions of normal and abnormal PrP (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_008818.16  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPRN gene promoter:
         GR   AP-1   GR-beta   MIF-1   Nkx5-1   Max   GR-alpha   c-Myc   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRN promoter sequence
   Search SABiosciences Chromatin IP Primers for SPRN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.3   Ensembl cytogenetic band:  10q26.3   HGNC cytogenetic band: 10q26.3

SPRN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRN gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M135234:  view genomic region     (about GC identifiers)

Start:
135,234,170 bp from pter      End:
135,382,916 bp from pter
Size:
148,747 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9 (See protein sequence)
Recommended Name: Shadow of prion protein precursor  
Size: 151 amino acids; 14522 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
Miscellaneous: 'Shadoo' means 'shadow' in Japanese

Explore the universe of human proteins at neXtProt for SPRN: NX_Q5BIV9

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5BIV9

  • SPRN Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001012526.2  
    ENSEMBL proteins: 
     ENSP00000433712   ENSP00000443979  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0031225anchored to membrane IEA--

    SPRN for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q5BIV9

    UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9
    Similarity: Belongs to the SPRN family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRN_HUMAN, Q5BIV9
    Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the
    biological actions of normal and abnormal PrP (By similarity)

    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sprn):

     behavior/neurological  growth/size  mortality/aging  nervous system 

    SPRN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Sprntm1Geno for SPRN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPRN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPRN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRN 

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    SwitchGear 3'UTR luciferase reporter plasmidSPRN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRN

    1 Interacting protein for SPRN (Q5BIV93) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STRN4Q9NRL33I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPRN

    Search CenterWatch for drugs/clinical trials and news about SPRN

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPRN gene: 
    NM_001012508.3  

    Unigene Cluster for SPRN:

    Shadow of prion protein homolog (zebrafish)
    Hs.64968  [show with all ESTs]
    Unigene Representative Sequence: NM_001012508
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000414069(uc001lnf.4) ENST00000541506
    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate SPRN (see all 9):
    hsa-miR-34c-5p hsa-miR-449b hsa-miR-133b hsa-miR-449a hsa-miR-34a hsa-miR-133a hsa-miR-4302 hsa-miR-205*
    SwitchGear 3'UTR luciferase reporter plasmidSPRN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRN
    Clone
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    OriGene clones in human, mouse for SPRN (see all 6)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRN
    Sirion Biotech Customized lentivirus for stable overexpression of SPRN 
                         Customized lentivirus expression plasmids for stable overexpression of SPRN 
    Primer
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    OriGene qPCR primer pairs and template standards for SPRN
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRN

    Additional mRNA sequence: BC040198.1 

    2 DOTS entries:

    DT.100811551  DT.87016111 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPRN expression in normal human tissues (normalized intensities)      SPRN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCAGGGCA
    SPRN Expression
    About this image


    SPRN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    Genevestigator expression for SPRN

    SOURCE GeneReport for Unigene cluster: Hs.64968

    UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9
    Tissue specificity: Mainly expressed in brain. In brain, it is expressed in hippocampus

        SABiosciences Custom PCR Arrays for SPRN
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPRN gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sprn1 , 5 shadow of prion protein1, 5 78.91(n)1
    81.63(a)1
      7 (85.17 cM)5
    2125181  NM_183147.21  NP_898970.11 
     1401506285 
    zebrafish
    (Danio rerio)
    Actinopterygii sprn6
    shadow of prion protein
    44(a)
    1 ↔ 1
    13(21822982-21828388)


    ENSEMBL Gene Tree for SPRN (if available)
    TreeFam Gene Tree for SPRN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3101 SNPs in SPRN are shown (see all 3101)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71004971,2
    C,F,A--135234736(+) GCATCG/ATGCCA 1 -- ut31 ese31Minor allele frequency- A:0.04WA 118
    rs79046261,2
    C,F,A,H--135234761(+) TGGGGC/TAGGAA 1 -- ut31 ese35Minor allele frequency- T:0.01NS EA WA 530
    rs557775111,2
    C,F--135234839(+) CATCAT/CAACTG 1 -- ut312Minor allele frequency- C:0.02NA EU 713
    rs22970331,2
    C,F,A--135234848(+) TGGAAC/TATTCC 1 -- ut31 ese38Minor allele frequency- T:0.35EA WA NA CSA EU 2457
    rs1909866621,2
    --135234868(+) CAGTGC/TTGTGG 1 -- ut310--------
    rs1455901771,2
    --135234881(+) TGTGAA/GGGTCT 1 -- ut310--------
    rs1825946891,2
    C--135234919(+) GGCATC/GTGCAA 1 -- ut310--------
    rs1477132941,2
    C--135234939(+) GGCTCC/TGGTGG 1 -- ut310--------
    rs1881064981,2
    --135235014(+) CTCTGC/TCTATG 1 -- ut310--------
    rs1425065911,2
    --135235017(+) TGCCTA/GTGAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SPRN (135234170 - 135382916 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/28 variations for SPRN (see all 28):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv2e196CNV Duplication17116639
    dgv3e196CNV Duplication17116639
    dgv891n71CNV Loss21882294
    dgv880n71CNV Loss21882294
    nsv528260CNV Loss19592680
    dgv889n71CNV Loss21882294
    nsv7631CNV Loss18451855
    nsv896317CNV Loss21882294
    dgv35e55CNV Gain17911159
    nsv428243CNV Gain18775914


    Human Gene Mutation Database (HGMD): SPRN
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SPRN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610447    OMIM disorders: --

    2 diseases for SPRN:    About MalaCards
    variant creutzfeldt-jakob disease    prion disease


    SPRN for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPRN
    Human Genome Epidemiology (HuGE) Navigator: SPRN (5 documents)

    Export disorders for SPRN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPRN gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SPRN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. (PubMed id 14527721)1, 2, 3, 9 Premzl M.... Gready J.E. (2003)
    2. Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. (PubMed id 18805828)1, 4, 9 Beck J.A....Mead S. (2008)
    3. Evolution of vertebrate genes related to prion and Shadoo proteins- Clues from comparative genomic analysis. (PubMed id 15342797)1, 2, 9 Premzl M....Marshall Graves J.A. (2004)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. Conserved stress-protective activity between prion pr otein and Shadoo. (PubMed id 21257747)1 Sakthivelu V....Tatzelt J. (2011)
    7. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    8. A novel solid phase technology for high-throughput gene synthesis. (PubMed id 18778261)1 Van den Brulle J....Schwer H. (2008)
    9. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
    10. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PubMed id 17903301)4 Vasan R.S....Benjamin E.J. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 503542 HGNC: 16871 Ensembl:ENSG00000203772 euGenes: HUgn503542 ECgene: SPRN
    H-InvDB: SPRN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPRN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPRN gene:
    Search GeneIP for patents involving SPRN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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