SPRN Gene
protein-coding GIFtS: 44
GCID: GC10M135234
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shadow of prion protein homolog (zebrafish)
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Aliases
for SPRN gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Shadow Of Prion Protein Homolog (Zebrafish)1 2 | | FLJ411971 | | SHO2 3 5 | | Shadoo1 | | BA108K14.11 | | Sprn1 | | Protein Shadoo2 3 | | Hypothetical Protein BC0044092 | | SHADOO2 5 | | Shadow Of Prion Protein2 |
Export aliases for SPRN gene to outside databasesPrevious GC identifers: GC10U900602 GC10M135085 GC10M128777 |
Summaries
for SPRN gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biologicalactions of normal and abnormal PrP (By similarity)
|
Genomic Views
for SPRN gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008818.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPRN gene promoter:
GR AP-1 GR-beta MIF-1 Nkx5-1 Max GR-alpha c-Myc Ik-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPRN
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRN |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3SPRN Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M135234: view genomic region
(about GC identifiers)
Start:
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135,234,170 bp from pter |
End:
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135,382,916 bp from pter |
Size:
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148,747 bases |
Orientation:
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minus strand |
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Proteins
for SPRN gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9 (See
protein sequence)Recommended Name: Shadow of prion protein precursor Size: 151 amino acids; 14522 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
Miscellaneous: 'Shadoo' means 'shadow' in JapaneseExplore the universe of human proteins at neXtProt for SPRN: NX_Q5BIV9
Post-translational modifications:
N-glycosylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5BIV9
SPRN Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001012526.2
ENSEMBL proteins: ENSP00000433712 ENSP00000443979
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0031225 | anchored to membrane |
IEA | -- |
SPRN for ontologies About GeneDecksing
SPRN Antibody Products:
Assay Products for SPRN: |
Protein
Domains /
Families
for SPRN gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5BIV9 UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9Similarity: Belongs to the SPRN family |
Function
for SPRN gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9Function: Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biologicalactions of normal and abnormal PrP (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for SPRN | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRN | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRN |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRN |
Animal Models:
Mouse knock-out Sprntm1Geno for SPRN
4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Sprn):
SPRN for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPRN gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPRN
1 Interacting protein for SPRN (Q5BIV93) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for SPRN gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPRN
Search CenterWatch for drugs/clinical trials and news about SPRN
|
Transcripts
for SPRN gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPRN gene: NM_001012508.3 Unigene Cluster for SPRN: Shadow of prion protein homolog (zebrafish) Hs.64968 [show with all ESTs]Unigene Representative Sequence: NM_0010125082 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000414069(uc001lnf.4) ENST00000541506
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRN (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRN
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for SPRN | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRN | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRN |
Additional cDNA sequence: BC040198.1 4 DOTS entries: DT.100811551 DT.87016111 DT.109218 DT.95225971
GeneLoc Exon Structure
|
Expression
for SPRN gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPRN expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCAGGGCA
About this image
Genevestigator expression for SPRN
SOURCE GeneReport for Unigene cluster: Hs.64968
UniProtKB/Swiss-Prot: SPRN_HUMAN, Q5BIV9Tissue specificity: Mainly expressed in brain. In brain, it is expressed in hippocampus
SABiosciences Custom PCR Arrays for SPRN
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRN
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SPRN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRN | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRN |
Orthologs
for SPRN gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for SPRN gene from 2/7 species (see all 7) About this table
ENSEMBL Gene Tree for SPRN (if available)
TreeFam Gene Tree for SPRN (if available) |
Paralogs
for SPRN gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPRN gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPRN (135234170 - 135382916 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 21 variations for SPRN
15/21 CNVs (see all 21): 2896 71206 6852 5270 8673 5272 2162 53842 48474 5273 48475 65826 34537 8671 3830
Human Gene Mutation Database (HGMD): SPRN
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRN |
|
Disorders
/ Diseases
for SPRN gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPRN for disorders About GeneDecksing
OMIM gene information: 610447
OMIM disorders: --
2  diseases for SPRN: About MalaCardsvariant creutzfeldt-jakob disease prion disease
Human Genome Epidemiology (HuGE) Navigator: SPRN (5 documents)
Export disorders for SPRN gene to outside databases
|
Publications
for SPRN gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPRN gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with SPRN) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. (PubMed id 14527721)1, 2, 3, 9 Premzl M.... Gready J.E. (2003)
- Evolution of vertebrate genes related to prion and Shadoo proteins- Clues from comparative genomic analysis. (PubMed id 15342797)1, 2, 9 Premzl M....Marshall Graves J.A. (2004)
- Association of a null allele of SPRN with variant Creutzfeldt-Jakob disease. (PubMed id 18805828)1, 9 Beck J.A....Mead S. (2008)
- Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
- Conserved stress-protective activity between prion pr otein and Shadoo. (PubMed id 21257747)1 Sakthivelu V....Tatzelt J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A novel solid phase technology for high-throughput gene synthesis. (PubMed id 18778261)1 Van den Brulle J....Schwer H. (2008)
- Comparative genomic analysis of prion genes. (PubMed id 17199895)2 Premzl M. and Gamulin V. (2007)
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External Searches for SPRN gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPRN gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPRN gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPRN gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPRN | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPRN gene:
Search GeneIP for patents involving SPRN
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPRN gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPRN | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRN | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRN | | | OriGene Protein Over-expression Lysate for SPRN | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPRN | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRN | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRN | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPRN | | OriGene Custom Protein Services for SPRN | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRN | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRN | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRN | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRN | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRN | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRN |
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| | | | Search Tocris compounds for SPRN |
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 | | | SPRN Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRN |
|  |  |  | | | | ThermoFisher Antibodies for SPRN |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRN |
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