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SPRED3 Gene

protein-coding   GIFtS: 46
GCID: GC19P038880

Sprouty-Related, EVH1 Domain Containing 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sprouty-Related, EVH1 Domain Containing 31 2
Eve-32
spred-32
Sprouty-Related, EVH1 Domain-Containing Protein 32
EVE-33
Spred-33

External Ids:    HGNC: 310411   Entrez Gene: 3994732   Ensembl: ENSG000001887667   OMIM: 6092935   UniProtKB: Q2MJR03   

Export aliases for SPRED3 gene to outside databases

Previous GC identifers: GC19U900378 GC19P043574 GC19P035328


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPRED3 Gene:
This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal
Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a
family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly
during organogenesis. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul
2012)

GeneCards Summary for SPRED3 Gene:
SPRED3 (sprouty-related, EVH1 domain containing 3) is a protein-coding gene. Diseases associated with SPRED3 include legius syndrome, and neurofibromatosis. An important paralog of this gene is ENAH.

UniProtKB/Swiss-Prot: SPRE3_HUMAN, Q2MJR0
Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity)

Gene Wiki entry for SPRED3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPRED3 gene promoter:
         E2F-4   E2F-3a   Elk-1   E2F-5   Nkx2-5   E2F-2   NRF-2   E2F-1   E2F   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SPRED3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRED3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13

SPRED3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRED3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P038880:  view genomic region     (about GC identifiers)

Start:
38,879,061 bp from pter      End:
38,886,881 bp from pter
Size:
7,821 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPRE3_HUMAN, Q2MJR0 (See protein sequence)
Recommended Name: Sprouty-related, EVH1 domain-containing protein 3  
Size: 410 amino acids; 42670 Da
Subunit: Interacts with Ras (By similarity)
Secondary accessions: Q2MJR1
Alternative splicing: 2 isoforms:  Q2MJR0-1   Q2MJR0-2   

Explore the universe of human proteins at neXtProt for SPRED3: NX_Q2MJR0

Explore proteomics data for SPRED3 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPRED3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001035987.1  
    ENSEMBL proteins: 
     ENSP00000467540   ENSP00000466568   ENSP00000467532   ENSP00000345405   ENSP00000465713  

    SPRED3 Human Recombinant Protein Products:

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    SPRED3 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for SPRED3

    SPRED3 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR007875 Sprouty
     IPR011993 PH_like_dom
     IPR000697 WH1/EVH1
     IPR023337 KBD

    Graphical View of Domain Structure for InterPro Entry Q2MJR0

    ProtoNet protein and cluster: Q2MJR0

    1 Blocks protein domain: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPRE3_HUMAN, Q2MJR0
    Similarity: Contains 1 KBD domain
    Similarity: Contains 1 SPR (sprouty) domain
    Similarity: Contains 1 WH1 domain


    SPRED3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRE3_HUMAN, Q2MJR0
    Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRED3
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    3 qRT-PCR Assays for microRNAs that regulate SPRED3:
    hsa-miR-3690 hsa-miR-3607-3p hsa-miR-2114*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPRED3

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    GenScript: all cDNA clones in your preferred vector (see all 2): SPRED3 (NM_001042522)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRED3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRED3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRED3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPRE3_HUMAN, Q2MJR0: Membrane; Peripheral membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    SPRED3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPRED3 About    
    See pathways by source

    SuperPathContained pathways About
    1Jak-STAT signaling pathway
    Jak-STAT signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for SPRED3):
        Jak-STAT signaling pathway


    SPRED3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRED3
    Interactions:

        Search GeneGlobe Interaction Network for SPRED3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SPRED3 (Q2MJR03 ENSP000003454054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    DAB2ENSP000003133914STRING: ENSP00000313391
    --ENSP000003602774STRING: ENSP00000360277
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0009966regulation of signal transduction ----

    SPRED3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRED3 (SPRE3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPRED3 gene (2 alternative transcripts): 
    NM_001042522.2  NM_001039616.1  

    Unigene Cluster for SPRED3:

    Sprouty-related, EVH1 domain containing 3
    Hs.196011  [show with all ESTs]
    Unigene Representative Sequence: NM_001042522
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587013 ENST00000586301 ENST00000587947 ENST00000338502(uc002oim.3)
    ENST00000587564 ENST00000586958 ENST00000590962
    miRNA
    Products:
         
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    3 qRT-PCR Assays for microRNAs that regulate SPRED3:
    hsa-miR-3690 hsa-miR-3607-3p hsa-miR-2114*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPRED3
    Predesigned siRNA for gene silencing in human, mouse, rat SPRED3
    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRED3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRED3
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat SPRED3
      QuantiFast Probe-based Assays in human, mouse, rat SPRED3

    Additional mRNA sequence: 

    BC151136.1 DQ323927.1 DQ323928.1 NR_073032.1 

    7 DOTS entries:

    DT.75100748  DT.97785874  DT.121459297  DT.95150352  DT.95203186  DT.95148822  DT.100661048 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPRED3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCGGGTCC
    SPRED3 Expression
    About this image

    SPRED3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRED3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.196011

    UniProtKB/Swiss-Prot: SPRE3_HUMAN, Q2MJR0
    Tissue specificity: Expression is restricted to liver

        Custom PCR Arrays for SPRED3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRED3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPRED3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spred31 , 5 sprouty-related, EVH1 domain containing 31, 5 87.14(n)1
    95.33(a)1
      7 (16.94 cM)5
    1018091  NM_182927.31  NP_891557.31 
     291588295 
    lizard
    (Anolis carolinensis)
    Reptilia SPRED36
    sprouty-related, EVH1 domain containing 3
    41(a)
    1 ↔ 1
    GL343427.1(438718-446593)
    fruit fly
    (Drosophila melanogaster)
    Insecta Spred6
    Sprouty-related protein with EVH-1 domain
    30(a)
    1 → many
    2R(10647151-10656927)


    ENSEMBL Gene Tree for SPRED3 (if available)
    TreeFam Gene Tree for SPRED3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPRED3 gene
    ENAH2  SPRED12  VASP2  EVL2  SPRED22  
    3 SIMAP similar genes for SPRED3 using alignment to 5 protein entries:     SPRE3_HUMAN (see all proteins):
    SPRED2    EVL    SPRED1

    SPRED3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPRED3 (see all 209)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420626941,2
    --38880734(+) AGAGAA/GAAGAG 2 -- us2k10--------
    rs3695854261,2
    C--38880871(+) GGAACA/GTCCAT 2 -- ut51 us2k10--------
    rs1470993341,2
    --38880884(+) GGAGAG/TCAGGG 2 -- ut51 us2k10--------
    rs3707014071,2
    C--38881095(+) ATCCAC/TGGGGA 3 H syn1 int10--------
    rs767939361,2
    C--38881127(+) GAGCCA/GCCCTG 2 -- int10--------
    rs1384659731,2
    --38881216(+) AGCCTA/GGGAAT 2 -- int10--------
    rs1806728871,2
    --38881259(+) CTGTCC/TTGTAG 2 -- int10--------
    rs1161320361,2
    F--38881368(+) TCCTCC/TCCGCT 2 -- int11Minor allele frequency- T:0.08WA 118
    rs1441271651,2
    --38881370(+) CTCCCC/TGCTCC 2 -- int10--------
    rs2001129771,2
    --38881413(+) CCCCC-/CACCCCG 2 -- int10--------

    HapMap Linkage Disequilibrium report for SPRED3 (38879061 - 38886881 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SPRED3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3857n71CNV Loss21882294
    nsv833823CNV Loss17160897
    nsv911658CNV Loss21882294
    nsv833822CNV Loss17160897
    nsv911659CNV Loss21882294
    nsv911660CNV Gain21882294
    nsv470140CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRED3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRED3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609293    OMIM disorders: --

    2 diseases for SPRED3:    
    About MalaCards
    legius syndrome    neurofibromatosis


    SPRED3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPRED3
    Human Genome Epidemiology (HuGE) Navigator: SPRED3 (1 document)

    Export disorders for SPRED3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPRED3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SPRED3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. (PubMed id 16478641)1, 2 King J.A.J.... Hovens C.M. (J. Hepatol. 2006)
    2. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. (PubMed id 14618415)1, 3 Mizoguchi M....Louis D.N. (Neurogenetics 2004)
    3. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PubMed id 16465403)1, 9 Katoh Y. and Katoh M. (Int. J. Mol. Med. 2006)
    4. Sprouty proteins: modified modulators, matchmakers or missing links? (PubMed id 19423641)1 Guy G.R....Chow S.Y. (J. Endocrinol. 2009)
    5. SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. (PubMed id 19443465)4 Spurlock G.... Upadhyaya M. (J. Med. Genet. 2009)
    6. Spred-2 steady-state levels are regulated by phosphorylation and Cbl- mediated ubiquitination. (PubMed id 17094949)1 Lock P.... Stylli S.S. (Biochem. Biophys. Res. Commun. 2006)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. (PubMed id 12646235)1 Kato R....Yoshimura A. (Biochem. Biophys. Res. Commun. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 399473 HGNC: 31041 Ensembl:ENSG00000188766 euGenes: HUgn399473 ECgene: SPRED3 Kegg: 399473
    H-InvDB: SPRED3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPRED3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPRED3 gene:
    Search GeneIP for patents involving SPRED3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Block miRNA regulation of human, mouse, rat SPRED3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPRED3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRED3 Predesigned siRNA for gene silencing in human, mouse, rat SPRED3
     QuantiFast Probe-based Assays in human, mouse, rat SPRED3 QuantiTect SYBR Green Assays in human, mouse, rat SPRED3
     Custom PCR Arrays for SPRED3 Search Chromatin IP Primers for SPRED3
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     Search Tocris compounds for SPRED3 (SPRE3)
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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     Browse ESI BIO Cell Lines and PureStem Progenitors for SPRED3
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     Search ThermoFisher Antibodies for SPRED3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRED3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRED3
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     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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