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Aliases for SPRED3 Gene

Aliases for SPRED3 Gene

  • Sprouty Related EVH1 Domain Containing 3 2 3 5
  • Spred-3 3 4
  • Eve-3 3 4
  • Sprouty-Related, EVH1 Domain-Containing Protein 3 3

External Ids for SPRED3 Gene

Previous GeneCards Identifiers for SPRED3 Gene

  • GC19U900378
  • GC19P043574
  • GC19P038880
  • GC19P035328

Summaries for SPRED3 Gene

Entrez Gene Summary for SPRED3 Gene

  • This gene encodes a protein with a C-terminal Sprouty-like cysteine-rich domain (SRY) and an N-terminal Ena/Vasodilator-stimulated phosphoprotein (VASP) homology-1 (EVH-1) domain. The encoded protein is a member of a family of proteins that negatively regulates mitogen-activated protein (MAP) kinase signaling, particularly during organogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for SPRED3 Gene

SPRED3 (Sprouty Related EVH1 Domain Containing 3) is a Protein Coding gene. Diseases associated with SPRED3 include Legius Syndrome. Among its related pathways are RET signaling and Immune System. An important paralog of this gene is SPRED2.

UniProtKB/Swiss-Prot for SPRED3 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.

Gene Wiki entry for SPRED3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED3 Gene

Genomics for SPRED3 Gene

Regulatory Elements for SPRED3 Gene

Enhancers for SPRED3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F038269 1.3 Ensembl ENCODE 10.4 -117.7 -117717 1.7 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF121 GLIS2 GATA2 KLF7 YY2 C19orf33 CATSPERG ENSG00000269688 ENSG00000266963 ENSG00000269445 ENSG00000267375 ENSG00000269172 ZNF573 KCNK6 DPF1
GH19F038361 1.1 ENCODE 11 -26.1 -26070 1.6 HDGF ATF1 PKNOX1 ZNF133 SIN3A ZNF2 ZNF48 YY1 ZNF121 GLIS2 C19orf33 ENSG00000266963 CATSPERG ENSG00000269445 ENSG00000267375 ENSG00000269172 ENSG00000267892 SPRED3 GGN FAM98C
GH19F038272 1.1 Ensembl ENCODE 10.4 -114.8 -114758 3.0 SOX13 ELF3 DRAP1 SAP130 DMAP1 ZNF384 BCL11B YY1 RARA ZNF121 C19orf33 CATSPERG ENSG00000266963 ENSG00000269445 ENSG00000267375 ENSG00000269172 DPF1 YIF1B KCNK6 SPRED3
GH19F038453 0.9 ENCODE 11.9 +64.7 64735 0.2 TBP ATF1 PKNOX1 CBX3 CREB3L1 CREM CEBPB HDAC8 SP1 TFDP1 FAM98C SPRED3 GGN CATSPERG PPP1R14A GC19P038435 GC19P038502
GH19F038233 0.9 ENCODE 10.3 -154.4 -154426 0.2 PKNOX1 KLF17 ARID4B ZNF48 ZNF2 RAD21 ZNF121 GLIS2 SCRT2 ZNF143 YIF1B PPP1R14A KCNK6 CATSPERG RASGRP4 RYR1 GGN SPRED3 FAM98C GC19M038235
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPRED3 on UCSC Golden Path with GeneCards custom track

Promoters for SPRED3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000346273 179 2801 HDGF ZNF133 ZNF2 ZNF48 ZNF121 GLIS2 ZNF143 KLF7 ZNF263 SP3

Genomic Location for SPRED3 Gene

38,388,421 bp from pter
38,399,884 bp from pter
11,464 bases
Plus strand

Genomic View for SPRED3 Gene

Genes around SPRED3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPRED3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPRED3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED3 Gene

Proteins for SPRED3 Gene

  • Protein details for SPRED3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q2MJR1

    Protein attributes for SPRED3 Gene

    410 amino acids
    Molecular mass:
    42670 Da
    Quaternary structure:
    • Interacts with Ras.

    Alternative splice isoforms for SPRED3 Gene


neXtProt entry for SPRED3 Gene

Post-translational modifications for SPRED3 Gene

Other Protein References for SPRED3 Gene

No data available for DME Specific Peptides for SPRED3 Gene

Domains & Families for SPRED3 Gene

Protein Domains for SPRED3 Gene

Suggested Antigen Peptide Sequences for SPRED3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KBD domain.
  • Contains 1 KBD domain.
  • Contains 1 SPR (sprouty) domain.
  • Contains 1 WH1 domain.
genes like me logo Genes that share domains with SPRED3: view

No data available for Gene Families for SPRED3 Gene

Function for SPRED3 Gene

Molecular function for SPRED3 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
genes like me logo Genes that share phenotypes with SPRED3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPRED3 Gene

Localization for SPRED3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED3 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPRED3 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SPRED3: view

Pathways & Interactions for SPRED3 Gene

SuperPathways for SPRED3 Gene

SuperPathway Contained pathways
1 RET signaling
2 Developmental Biology
3 Cytokine Signaling in Immune system
4 Immune System
5 Signaling by PTK6
genes like me logo Genes that share pathways with SPRED3: view

Pathways by source for SPRED3 Gene

Interacting Proteins for SPRED3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
Selected Interacting proteins: ENSP00000345405 Q2MJR0-SPRE3_HUMAN for SPRED3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for SPRED3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with SPRED3: view

No data available for SIGNOR curated interactions for SPRED3 Gene

Transcripts for SPRED3 Gene

mRNA/cDNA for SPRED3 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPRED3 Gene

Sprouty-related, EVH1 domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED3 Gene

No ASD Table

Relevant External Links for SPRED3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRED3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPRED3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPRED3 Gene

This gene is overexpressed in Artery - Aorta (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRED3 Gene

Protein tissue co-expression partners for SPRED3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SPRED3 Gene:


SOURCE GeneReport for Unigene cluster for SPRED3 Gene:


mRNA Expression by UniProt/SwissProt for SPRED3 Gene:

Tissue specificity: Expression is restricted to liver.
genes like me logo Genes that share expression patterns with SPRED3: view

Primer Products

No data available for Protein differential expression in normal tissues for SPRED3 Gene

Orthologs for SPRED3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRED3 34 35
  • 99.59 (n)
(Canis familiaris)
Mammalia SPRED3 34 35
  • 92.6 (n)
(Bos Taurus)
Mammalia SPRED3 34 35
  • 91.33 (n)
(Mus musculus)
Mammalia Spred3 34 16 35
  • 87.14 (n)
(Rattus norvegicus)
Mammalia Spred3 34
  • 83.02 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 30 (a)
(Anolis carolinensis)
Reptilia SPRED3 35
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spred 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 35
  • 22 (a)
Species where no ortholog for SPRED3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPRED3 Gene

Gene Tree for SPRED3 (if available)
Gene Tree for SPRED3 (if available)

Paralogs for SPRED3 Gene

Paralogs for SPRED3 Gene

(3) SIMAP similar genes for SPRED3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SPRED3: view

Variants for SPRED3 Gene

Sequence variations from dbSNP and Humsavar for SPRED3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111246621 -- 38,393,654(+) TACGG(C/T)CTATC intron-variant
rs111992491 -- 38,392,326(+) GGGTA(A/G)GGGTT intron-variant
rs112133734 -- 38,396,073(+) CTGCG(C/T)GCGTG nc-transcript-variant, reference, synonymous-codon
rs112201791 -- 38,394,772(+) GCCGC(A/C/T)GCTCC nc-transcript-variant, reference, missense
rs112397399 -- 38,391,340(+) AAAAA(-/G)AGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRED3 Gene

Variant ID Type Subtype PubMed ID
nsv1064275 CNV loss 25217958
nsv470140 CNV gain 18288195
nsv833822 CNV loss 17160897
nsv833823 CNV loss 17160897
nsv953296 CNV deletion 24416366

Variation tolerance for SPRED3 Gene

Gene Damage Index Score: 2.68; 46.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRED3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED3 Gene

Disorders for SPRED3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPRED3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
legius syndrome
  • neurofibromatosis type 1-like syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPRED3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPRED3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRED3 Gene

Publications for SPRED3 Gene

  1. Eve-3: a liver enriched suppressor of Ras/MAPK signaling. (PMID: 16478641) King J.A.J. … Hovens C.M. (J. Hepatol. 2006) 3 4 64
  2. FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells. (PMID: 16465403) Katoh Y. … Katoh M. (Int. J. Mol. Med. 2006) 3 22 64
  3. Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma. (PMID: 14618415) Mizoguchi M. … Louis D.N. (Neurogenetics 2004) 2 3 64
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3 64
  5. Sprouty proteins: modified modulators, matchmakers or missing links? (PMID: 19423641) Guy G.R. … Chow S.Y. (J. Endocrinol. 2009) 3 64

Products for SPRED3 Gene

Sources for SPRED3 Gene

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