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SPRED2 Gene

protein-coding   GIFtS: 62
GCID: GC02M065537

Sprouty-Related, EVH1 Domain Containing 2

  See SPRED2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sprouty-Related, EVH1 Domain Containing 21 2
Spred-22 3
Sprouty Protein With EVH-1 Domain 2, Related Sequence2
Sprouty-Related, EVH1 Domain-Containing Protein 22

External Ids:    HGNC: 177221   Entrez Gene: 2007342   Ensembl: ENSG000001983697   OMIM: 6092925   UniProtKB: Q7Z6983   

Export aliases for SPRED2 gene to outside databases

Previous GC identifers: GC02M065495 GC02M065512 GC02M065449 GC02M065272


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPRED2 Gene:
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth
factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 (PubMed
15465815)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SPRED2 Gene:
SPRED2 (sprouty-related, EVH1 domain containing 2) is a protein-coding gene. Diseases associated with SPRED2 include legius syndrome. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRED3.

UniProtKB/Swiss-Prot: SPRE2_HUMAN, Q7Z698
Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase

Gene Wiki entry for SPRED2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPRED2 gene promoter:
         Bach1   FOXF2   Pax-5   NF-AT   FOXL1   NF-AT4   SRY   NF-AT2   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPRED2 promoter sequence
   Search Chromatin IP Primers for SPRED2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPRED2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p14   Ensembl cytogenetic band:  2p14   HGNC cytogenetic band: 2p14

SPRED2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPRED2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M065537:  view genomic region     (about GC identifiers)

Start:
65,537,985 bp from pter      End:
65,659,771 bp from pter
Size:
121,787 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPRE2_HUMAN, Q7Z698 (See protein sequence)
Recommended Name: Sprouty-related, EVH1 domain-containing protein 2  
Size: 418 amino acids; 47558 Da
Subunit: Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form
heterodimers
1 PDB 3D structure from and Proteopedia for SPRED2:
2JP2 (3D)    
Secondary accessions: A1L3V4 B7Z5K7 D6W5F7 E9PEP0 Q2NKX6
Alternative splicing: 2 isoforms:  Q7Z698-1   Q7Z698-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPRED2: NX_Q7Z698

Explore proteomics data for SPRED2 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination1
  • Ubiquitinated; leading to degradation by the proteasome1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPRED2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001121682.1  NP_861449.2  

    ENSEMBL proteins: 
     ENSP00000348753   ENSP00000393697   ENSP00000390595   ENSP00000407627   ENSP00000414551  
     ENSP00000406481   ENSP00000393148  

    SPRED2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SPRED2
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    Novus Biologicals SPRED2 Proteins
    Novus Biologicals SPRED2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPRED2

     
    Search eBioscience for Proteins for SPRED2 

    SPRED2 Antibody Products:

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    Search eBioscience for ELISAs for SPRED2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR007875 Sprouty
     IPR011993 PH_like_dom
     IPR000697 WH1/EVH1
     IPR023337 KBD

    Graphical View of Domain Structure for InterPro Entry Q7Z698

    ProtoNet protein and cluster: Q7Z698

    1 Blocks protein domain: IPB007875 Sprouty

    UniProtKB/Swiss-Prot: SPRE2_HUMAN, Q7Z698
    Similarity: Contains 1 KBD domain
    Similarity: Contains 1 SPR (sprouty) domain
    Similarity: Contains 1 WH1 domain


    Find genes that share domains with SPRED2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPRE2_HUMAN, Q7Z698
    Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005173stem cell factor receptor binding ISS--
    GO:0005515protein binding IPI19822672
    GO:0019901protein kinase binding IPI--
    GO:0030291protein serine/threonine kinase inhibitor activity ISS--
         
    Find genes that share ontologies with SPRED2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SPRED2:
     Decreased focal adhesion (FA)   Decreased viability with pacli 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Spred2):
     growth/size/body  hematopoietic system  limbs/digits/tail  reproductive system  skeleton 

    Find genes that share phenotypes with SPRED2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Spred2tm1Taga for SPRED2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPRED2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPRED2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPRED2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPRED2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPRED2:
    hsa-mir-186-5p (MIRT021167)

    Block miRNA regulation of human, mouse, rat SPRED2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPRED2 (see all 32):
    hsa-miR-485-5p hsa-miR-3146 hsa-miR-509-5p hsa-miR-487a hsa-miR-485-3p hsa-miR-938 hsa-miR-340 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidSPRED2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPRED2
    Predesigned siRNA for gene silencing in human, mouse, rat SPRED2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): SPRED2 (NM_181784)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPRED2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRED2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRED2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPRE2_HUMAN, Q7Z698: Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic
    vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm.
    Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with SPRED2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPRED2 About    
    See pathways by source

    SuperPathContained pathways About
    1Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)0.37
    Kit Receptor Signaling Pathway0.37
    2Jak-STAT signaling pathway
    Jak-STAT signaling pathway


    Find genes that share SuperPaths with SPRED2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for SPRED2
        Kit Receptor Signaling Pathway
    Signaling events mediated by Stem cell factor receptor (c-Kit)


    1 Kegg Pathway  (Kegg details for SPRED2):
        Jak-STAT signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPRED2
    Interactions:

        Search GeneGlobe Interaction Network for SPRED2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SPRED2 (Q7Z6982, 3 ENSP000003487534) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CBLP226812, 3, ENSP000002640334MINT-8031653 MINT-8034108 I2D: score=1 STRING: ENSP00000264033
    KITP107213, ENSP000002881354I2D: score=2 STRING: ENSP00000288135
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    TESK1Q155693, ENSP000003381274I2D: score=1 STRING: ENSP00000338127
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000188inactivation of MAPK activity ISS--
    GO:0007275multicellular organismal development IEA--
    GO:0009966regulation of signal transduction ----
    GO:0010801negative regulation of peptidyl-threonine phosphorylation IMP--
    GO:0043517positive regulation of DNA damage response, signal transduction by p53 class mediator ISS--

    Find genes that share ontologies with SPRED2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPRED2 (SPRE2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPRED2 gene (2 alternative transcripts): 
    NM_001128210.1  NM_181784.2  

    Unigene Cluster for SPRED2:

    Sprouty-related, EVH1 domain containing 2
    Hs.59332  [show with all ESTs]
    Unigene Representative Sequence: NM_181784
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356388(uc010fcw.3 uc002sdr.4 uc010fcx.1) ENST00000443619
    ENST00000452315 ENST00000421087 ENST00000474228 ENST00000426832 ENST00000440972
    ENST00000427238
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate SPRED2 (see all 32):
    hsa-miR-485-5p hsa-miR-3146 hsa-miR-509-5p hsa-miR-487a hsa-miR-485-3p hsa-miR-938 hsa-miR-340 hsa-miR-218
    SwitchGear 3'UTR luciferase reporter plasmidSPRED2 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for SPRED2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPRED2
      QuantiTect SYBR Green Assays in human, mouse, rat SPRED2
      QuantiFast Probe-based Assays in human, mouse, rat SPRED2

    Additional mRNA sequence: 

    AF052178.1 AK025550.1 AK056479.1 AK299079.1 AK307714.1 AY299090.1 BC029300.1 BC111495.1 
    BC130292.1 BC136334.1 

    11 DOTS entries:

    DT.451903  DT.40106961  DT.201521  DT.95098343  DT.101958206  DT.95098342  DT.120962114  DT.120962124 
    DT.92425600  DT.95098292  DT.95190414 

    Selected AceView cDNA sequences (see all 246):

    BX505919 AA635014 AA210702 AA736862 AA766026 AA370348 AA890045 BM470807 
    AI694982 AA478058 AA864731 CR609442 BC029300 BQ267914 CF528598 R19506 
    BQ008450 AI015646 BE888305 AA827661 AW169350 AA488875 AI017816 BE466474 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPRED2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
    SP1:              -                                 
    SP2:                                                
    SP3:        -     -                                 
    SP4:              -           -                     


    ECgene alternative splicing isoforms for SPRED2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPRED2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGACATTTA
    SPRED2 Expression
    About this image


    SPRED2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    SPRED2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPRED2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59332

    UniProtKB/Swiss-Prot: SPRE2_HUMAN, Q7Z698
    Tissue specificity: Expressed in liver, skin, small intestine, salivary gland and prostate

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    QuantiFast Probe-based Assays in human, mouse, rat SPRED2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRED2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPRED2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spred21 , 5 sprouty-related, EVH1 domain containing 21, 5 88.21(n)1
    93.9(a)1
      11 (12.79 cM)5
    1147161  NM_033523.41  NP_277058.11 
     199243755 
    chicken
    (Gallus gallus)
    Aves SPRED21 sprouty-related, EVH1 domain containing 2 76.6(n)
    86.21(a)
      421271  XM_419341.4  XP_419341.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPRED26
    sprouty-related, EVH1 domain containing 2
    86(a)
    1 ↔ 1
    1(124573904-124658401)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM261751.12   -- 81.24(n)    BM261751.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb93f082 Transcribed sequence with weak similarity to protein more 77.06(n)    57044097 
    fruit fly
    (Drosophila melanogaster)
    Insecta Spred1 Sprouty-related protein with EVH-1 domain 49.39(n)
    38.95(a)
      36643  NM_137144.3  NP_610988.1 


    ENSEMBL Gene Tree for SPRED2 (if available)
    TreeFam Gene Tree for SPRED2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPRED2 gene
    SPRED32  ENAH2  SPRED12  VASP2  EVL2  
    3 SIMAP similar genes for SPRED2 using alignment to 6 protein entries:     SPRE2_HUMAN (see all proteins):
    SPRED1    EVL    SPRED3

    Find genes that share paralogs with SPRED2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPRED2 (see all 2619)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs720056931,2
    C--65438638(+) GTTGT-/TTTTTTT 2 -- int10--------
    rs1119597911,2
    C--65486668(+) AAGGCT/-TTTTT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs3693953351,2
    C--65537593(+) CAAAC-/ACACAC
            
    CACAC
    2 -- int10--------
    rs1400950911,2
    --65537789(+) CATCCA/GAGCCC 2 -- int10--------
    rs1454166851,2
    --65537881(+) TCCTTC/TGGCAC 2 -- int10--------
    rs1849186581,2
    --65537882(+) CCTTCA/GGCACA 2 -- int10--------
    rs1477015151,2
    --65537934(+) GCCAAC/TGCTCT 2 -- int10--------
    rs1878409991,2
    --65537935(+) CCAACA/GCTCTA 2 -- int10--------
    rs587997441,2
    C,F--65537937(+) AACGCT/GCTAGC 2 -- int11Minor allele frequency- G:0.05WA 118
    rs1409291681,2
    --65537981(+) AGCCAG/TCGATC 2 -- int10--------

    HapMap Linkage Disequilibrium report for SPRED2 (65537985 - 65659771 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for SPRED2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2045738CNV Deletion18987734
    esv2720155CNV Deletion23290073
    esv2720156CNV Deletion23290073
    esv2720153CNV Deletion23290073
    esv2720158CNV Deletion23290073
    esv2720154CNV Deletion23290073
    esv2720157CNV Deletion23290073
    nsv2758CNV Insertion18451855
    nsv213210CNV Loss16902084
    nsv874239CNV Gain21882294

    Human Gene Mutation Database (HGMD): SPRED2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPRED2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPRED2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609292    OMIM disorders: --

    1 disease for SPRED2:    
    About MalaCards
    legius syndrome


    Find genes that share disorders with SPRED2           About GenesLikeMe

    Genetic Association Database (GAD): SPRED2
    Human Genome Epidemiology (HuGE) Navigator: SPRED2 (7 documents)

    Export disorders for SPRED2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPRED2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with SPRED2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Spred-2 steady-state levels are regulated by phosphorylation and Cbl- mediated ubiquitination. (PubMed id 17094949)1, 2, 9 Lock P.... Stylli S.S. (Biochem. Biophys. Res. Commun. 2006)
    2. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PubMed id 21383967)1, 4 Zhernakova A....Plenge R.M. (PLoS Genet. 2011)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    6. Distinct requirements for the Sprouty domain for functional activity of Spred proteins. (PubMed id 15683364)1, 2 King J.A.J.... Hovens C.M. (Biochem. J. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. 1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain. (PubMed id 15213456)1, 2 Zimmermann J.... Ball L.J. (J. Biomol. NMR 2004)
    9. Expression and subcellular localization of Spred proteins in mouse and human tissues. (PubMed id 15580519)1, 2 Engelhardt C.M.... Schuh K. (Histochem. Cell Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 200734 HGNC: 17722 AceView: SPRED2 Ensembl:ENSG00000198369 euGenes: HUgn200734
    ECgene: SPRED2 Kegg: 200734 H-InvDB: SPRED2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SPRED2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SPRED2 gene:
    Search GeneIP for patents involving SPRED2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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