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Aliases for SPRED2 Gene

Aliases for SPRED2 Gene

  • Sprouty-Related, EVH1 Domain Containing 2 2 3
  • Spred-2 3 4
  • Sprouty Protein With EVH-1 Domain 2, Related Sequence 3
  • Sprouty-Related, EVH1 Domain-Containing Protein 2 3

External Ids for SPRED2 Gene

Previous GeneCards Identifiers for SPRED2 Gene

  • GC02M065495
  • GC02M065512
  • GC02M065449
  • GC02M065537

Summaries for SPRED2 Gene

Entrez Gene Summary for SPRED2 Gene

  • SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SPRED2 Gene

SPRED2 (Sprouty-Related, EVH1 Domain Containing 2) is a Protein Coding gene. Diseases associated with SPRED2 include legius syndrome. Among its related pathways are Kit Receptor Signaling Pathway and Kit Receptor Signaling Pathway. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is SPRED1.

UniProtKB/Swiss-Prot for SPRED2 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase

Gene Wiki entry for SPRED2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED2 Gene

Genomics for SPRED2 Gene

Regulatory Elements for SPRED2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPRED2 Gene

65,307,442 bp from pter
65,432,637 bp from pter
125,196 bases
Minus strand

Genomic View for SPRED2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED2 Gene

Proteins for SPRED2 Gene

  • Protein details for SPRED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • A1L3V4
    • B7Z5K7
    • D6W5F7
    • E9PEP0
    • Q2NKX6

    Protein attributes for SPRED2 Gene

    418 amino acids
    Molecular mass:
    47558 Da
    Quaternary structure:
    • Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers.

    Three dimensional structures from OCA and Proteopedia for SPRED2 Gene

    Alternative splice isoforms for SPRED2 Gene


neXtProt entry for SPRED2 Gene

Proteomics data for SPRED2 Gene at MOPED

Post-translational modifications for SPRED2 Gene

  • Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination.
  • Ubiquitinated; leading to degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SPRED2 Gene

Domains for SPRED2 Gene

Protein Domains for SPRED2 Gene


Suggested Antigen Peptide Sequences for SPRED2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q7Z698
  • Contains 1 KBD domain.
  • Contains 1 SPR (sprouty) domain.
  • Contains 1 WH1 domain.
genes like me logo Genes that share domains with SPRED2: view

No data available for Gene Families for SPRED2 Gene

Function for SPRED2 Gene

Molecular function for SPRED2 Gene

UniProtKB/Swiss-Prot Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase

Gene Ontology (GO) - Molecular Function for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005173 stem cell factor receptor binding ISS --
GO:0005515 protein binding IPI 19822672
GO:0019901 protein kinase binding IPI 20736167
GO:0030291 protein serine/threonine kinase inhibitor activity ISS 20736167
genes like me logo Genes that share ontologies with SPRED2: view
genes like me logo Genes that share phenotypes with SPRED2: view

Animal Models for SPRED2 Gene

MGI Knock Outs for SPRED2:

Animal Model Products

CRISPR Products

miRNA for SPRED2 Gene

miRTarBase miRNAs that target SPRED2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPRED2 Gene

Localization for SPRED2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED2 Gene

Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.

Subcellular locations from

Jensen Localization Image for SPRED2 Gene COMPARTMENTS Subcellular localization image for SPRED2 gene
Compartment Confidence
cytosol 3
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SPRED2: view

Pathways for SPRED2 Gene

genes like me logo Genes that share pathways with SPRED2: view

Pathways by source for SPRED2 Gene

Gene Ontology (GO) - Biological Process for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0007275 multicellular organismal development IEA --
GO:0009966 regulation of signal transduction --
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP 20736167
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator ISS 20736167
genes like me logo Genes that share ontologies with SPRED2: view

Transcripts for SPRED2 Gene

Unigene Clusters for SPRED2 Gene

Sprouty-related, EVH1 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP3: - -
SP4: - -

Relevant External Links for SPRED2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRED2 Gene

mRNA expression in normal human tissues for SPRED2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPRED2 Gene

SOURCE GeneReport for Unigene cluster for SPRED2 Gene Hs.59332

mRNA Expression by UniProt/SwissProt for SPRED2 Gene

Tissue specificity: Expressed in liver, skin, small intestine, salivary gland and prostate.
genes like me logo Genes that share expressions with SPRED2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPRED2 Gene

Orthologs for SPRED2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPRED2 35
  • 98.79 (n)
  • 98.3 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SPRED2 35
  • 94.16 (n)
  • 97.84 (a)
  • 91 (a)
(Canis familiaris)
Mammalia SPRED2 35
  • 92.86 (n)
  • 95.13 (a)
  • 94 (a)
(Mus musculus)
Mammalia Spred2 35
  • 88.21 (n)
  • 93.9 (a)
Spred2 16
Spred2 36
  • 94 (a)
(Monodelphis domestica)
Mammalia SPRED2 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia SPRED2 36
  • 79 (a)
(Rattus norvegicus)
Mammalia Spred2 35
  • 88.78 (n)
  • 94.15 (a)
(Gallus gallus)
Aves SPRED2 35
  • 76.6 (n)
  • 86.21 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia SPRED2 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spred2 35
  • 71.56 (n)
  • 77.02 (a)
Str.15856 35
(Danio rerio)
Actinopterygii spred2a 36
  • 67 (a)
spred2b 35
  • 70.53 (n)
  • 72.41 (a)
spred2b 36
  • 69 (a)
wufb93f08 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012085 35
  • 35.78 (n)
  • 22.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spred 35
  • 49.39 (n)
  • 38.95 (a)
Spred 36
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 36
  • 24 (a)
Species with no ortholog for SPRED2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRED2 Gene

Gene Tree for SPRED2 (if available)
Gene Tree for SPRED2 (if available)

Paralogs for SPRED2 Gene

Paralogs for SPRED2 Gene

Selected SIMAP similar genes for SPRED2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SPRED2: view

Variants for SPRED2 Gene

Sequence variations from dbSNP and Humsavar for SPRED2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8827 -- 65,313,771(-) GACGC(C/G)CCCGA synonymous-codon, reference, intron-variant
rs11161 -- 65,313,343(-) AGGGA(C/T)GCTGC utr-variant-3-prime, intron-variant
rs14294 -- 65,311,953(-) AGACA(C/T)GGCCT utr-variant-3-prime, intron-variant
rs15221 -- 65,311,983(+) GAAAG(A/G)TCGTG utr-variant-3-prime, intron-variant
rs174847 -- 65,378,060(-) GGATG(A/G)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRED2 Gene

Variant ID Type Subtype PubMed ID
esv2720153 CNV Deletion 23290073
esv2720154 CNV Deletion 23290073
nsv213210 CNV Loss 16902084
esv2720155 CNV Deletion 23290073
esv2720156 CNV Deletion 23290073
esv2045738 CNV Deletion 18987734
esv2720157 CNV Deletion 23290073
esv2720158 CNV Deletion 23290073
nsv2758 CNV Insertion 18451855
nsv874239 CNV Gain 21882294

Relevant External Links for SPRED2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED2 Gene

Disorders for SPRED2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SPRED2 Gene including...

Search for SPRED2 Gene in MalaCards »

Relevant External Links for SPRED2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPRED2: view

No data available for UniProtKB/Swiss-Prot for SPRED2 Gene

Publications for SPRED2 Gene

  1. Spred-2 steady-state levels are regulated by phosphorylation and Cbl- mediated ubiquitination. (PMID: 17094949) Lock P. … Stylli S.S. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. 1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain. (PMID: 15213456) Zimmermann J. … Ball L.J. (J. Biomol. NMR 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Expression and subcellular localization of Spred proteins in mouse and human tissues. (PMID: 15580519) Engelhardt C.M. … Schuh K. (Histochem. Cell Biol. 2004) 3 4

Products for SPRED2 Gene

Sources for SPRED2 Gene

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