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Aliases for SPRED2 Gene

Aliases for SPRED2 Gene

  • Sprouty-Related, EVH1 Domain Containing 2 2 3
  • Spred-2 3 4
  • Sprouty Protein With EVH-1 Domain 2, Related Sequence 3

External Ids for SPRED2 Gene

Previous GeneCards Identifiers for SPRED2 Gene

  • GC02M065495
  • GC02M065512
  • GC02M065449
  • GC02M065537

Summaries for SPRED2 Gene

Entrez Gene Summary for SPRED2 Gene

  • SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SPRED2 Gene

SPRED2 (Sprouty-Related, EVH1 Domain Containing 2) is a Protein Coding gene. Diseases associated with SPRED2 include legius syndrome. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and stem cell factor receptor binding. An important paralog of this gene is SPRED1.

UniProtKB/Swiss-Prot for SPRED2 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase

Gene Wiki entry for SPRED2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED2 Gene

Genomics for SPRED2 Gene

Regulatory Elements for SPRED2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPRED2 Gene

Chromosome:
2
Start:
65,307,435 bp from pter
End:
65,432,637 bp from pter
Size:
125,203 bases
Orientation:
Minus strand

Genomic View for SPRED2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRED2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED2 Gene

Proteins for SPRED2 Gene

  • Protein details for SPRED2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z698-SPRE2_HUMAN
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 2
    Protein Accession:
    Q7Z698
    Secondary Accessions:
    • A1L3V4
    • B7Z5K7
    • D6W5F7
    • E9PEP0
    • Q2NKX6

    Protein attributes for SPRED2 Gene

    Size:
    418 amino acids
    Molecular mass:
    47558 Da
    Quaternary structure:
    • Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers.

    Three dimensional structures from OCA and Proteopedia for SPRED2 Gene

    Alternative splice isoforms for SPRED2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPRED2 Gene

Proteomics data for SPRED2 Gene at MOPED

Post-translational modifications for SPRED2 Gene

  • Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination.
  • Ubiquitinated; leading to degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for SPRED2

No data available for DME Specific Peptides for SPRED2 Gene

Domains & Families for SPRED2 Gene

Protein Domains for SPRED2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPRED2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z698

UniProtKB/Swiss-Prot:

SPRE2_HUMAN :
  • Contains 1 KBD domain.
Domain:
  • Contains 1 KBD domain.
  • Contains 1 SPR (sprouty) domain.
  • Contains 1 WH1 domain.
genes like me logo Genes that share domains with SPRED2: view

No data available for Gene Families for SPRED2 Gene

Function for SPRED2 Gene

Molecular function for SPRED2 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase

Gene Ontology (GO) - Molecular Function for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005173 stem cell factor receptor binding ISS --
GO:0005515 protein binding IPI 19822672
GO:0019901 protein kinase binding IPI 20736167
GO:0030291 protein serine/threonine kinase inhibitor activity ISS 20736167
genes like me logo Genes that share ontologies with SPRED2: view
genes like me logo Genes that share phenotypes with SPRED2: view

Animal Models for SPRED2 Gene

MGI Knock Outs for SPRED2:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPRED2 Gene

Localization for SPRED2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED2 Gene

Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRED2 Gene COMPARTMENTS Subcellular localization image for SPRED2 gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0030658 transport vesicle membrane IEA --
genes like me logo Genes that share ontologies with SPRED2: view

Pathways & Interactions for SPRED2 Gene

SuperPathways for SPRED2 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Immune System
3 Signaling by GPCR
4 Developmental Biology
5 Kit Receptor Signaling Pathway
genes like me logo Genes that share pathways with SPRED2: view

Gene Ontology (GO) - Biological Process for SPRED2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0007275 multicellular organismal development IEA --
GO:0009966 regulation of signal transduction --
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP 20736167
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator ISS 20736167
genes like me logo Genes that share ontologies with SPRED2: view

No data available for SIGNOR curated interactions for SPRED2 Gene

Drugs & Compounds for SPRED2 Gene

No Compound Related Data Available

Transcripts for SPRED2 Gene

Unigene Clusters for SPRED2 Gene

Sprouty-related, EVH1 domain containing 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2:
SP3: - -
SP4: - -

Relevant External Links for SPRED2 Gene

GeneLoc Exon Structure for
SPRED2
ECgene alternative splicing isoforms for
SPRED2

Expression for SPRED2 Gene

mRNA expression in normal human tissues for SPRED2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPRED2 Gene

This gene is overexpressed in Pancreas (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPRED2 Gene



SOURCE GeneReport for Unigene cluster for SPRED2 Gene Hs.59332

mRNA Expression by UniProt/SwissProt for SPRED2 Gene

Q7Z698-SPRE2_HUMAN
Tissue specificity: Expressed in liver, skin, small intestine, salivary gland and prostate.
genes like me logo Genes that share expression patterns with SPRED2: view

Protein tissue co-expression partners for SPRED2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPRED2 Gene

Orthologs for SPRED2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPRED2 35
  • 94.16 (n)
  • 97.84 (a)
SPRED2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPRED2 35
  • 92.86 (n)
  • 95.13 (a)
SPRED2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spred2 35
  • 88.21 (n)
  • 93.9 (a)
Spred2 16
Spred2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPRED2 35
  • 98.79 (n)
  • 98.3 (a)
SPRED2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spred2 35
  • 88.78 (n)
  • 94.15 (a)
oppossum
(Monodelphis domestica)
Mammalia SPRED2 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPRED2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPRED2 35
  • 76.6 (n)
  • 86.21 (a)
SPRED2 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPRED2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spred2 35
  • 71.56 (n)
  • 77.02 (a)
Str.15856 35
zebrafish
(Danio rerio)
Actinopterygii spred2b 35
  • 70.53 (n)
  • 72.41 (a)
wufb93f08 35
spred2a 36
  • 67 (a)
OneToMany
spred2b 36
  • 69 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012085 35
  • 35.78 (n)
  • 22.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spred 35
  • 49.39 (n)
  • 38.95 (a)
Spred 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 36
  • 24 (a)
OneToMany
Species with no ortholog for SPRED2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRED2 Gene

ENSEMBL:
Gene Tree for SPRED2 (if available)
TreeFam:
Gene Tree for SPRED2 (if available)

Paralogs for SPRED2 Gene

Paralogs for SPRED2 Gene

(3) SIMAP similar genes for SPRED2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SPRED2: view

Variants for SPRED2 Gene

Sequence variations from dbSNP and Humsavar for SPRED2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs35282483 -- 65,353,940(+) TGTCC(-/T)TAGTC intron-variant
rs35288733 -- 65,359,423(+) GAAAG(-/A)AACTC intron-variant
rs35290573 -- 65,331,277(+) AAGGA(A/G)AGAAA intron-variant
rs35312858 -- 65,391,501(+) TTCAG(A/T)TTTGT intron-variant
rs35314632 -- 65,353,391(+) ATTTT(-/T)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRED2 Gene

Variant ID Type Subtype PubMed ID
esv2720153 CNV Deletion 23290073
esv2720154 CNV Deletion 23290073
nsv213210 CNV Loss 16902084
esv2720155 CNV Deletion 23290073
esv2720156 CNV Deletion 23290073
esv2045738 CNV Deletion 18987734
esv2720157 CNV Deletion 23290073
esv2720158 CNV Deletion 23290073
nsv2758 CNV Insertion 18451855
nsv874239 CNV Gain 21882294

Variation tolerance for SPRED2 Gene

Residual Variation Intolerance Score: 18.59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRED2 Gene

HapMap Linkage Disequilibrium report
SPRED2
Human Gene Mutation Database (HGMD)
SPRED2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED2 Gene

Disorders for SPRED2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPRED2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
legius syndrome
  • neurofibromatosis type 1-like syndrome
- elite association

Relevant External Links for SPRED2

Genetic Association Database (GAD)
SPRED2
Human Genome Epidemiology (HuGE) Navigator
SPRED2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPRED2
genes like me logo Genes that share disorders with SPRED2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPRED2 Gene

Publications for SPRED2 Gene

  1. Spred-2 steady-state levels are regulated by phosphorylation and Cbl- mediated ubiquitination. (PMID: 17094949) Lock P. … Stylli S.S. (Biochem. Biophys. Res. Commun. 2006) 23 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. (PMID: 24782177) Jiang L. … Xu H. ( 2014) 67
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 67
  5. Evidence for downregulation of the negative regulator SPRED2 in clinical prostate cancer. (PMID: 23169297) Kachroo N. … Gnanapragasam V.J. (Br. J. Cancer 2013) 67

Products for SPRED2 Gene

Sources for SPRED2 Gene

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