Aliases for SPRED1 Gene
External Ids for SPRED1 Gene
Previous GeneCards Identifiers for SPRED1 Gene
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]
GeneCards Summary for SPRED1 Gene
SPRED1 (Sprouty Related EVH1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SPRED1 include Legius Syndrome and Neurofibromatosis, Type 1. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Kit Receptor Signaling Pathway. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is ENAH.
UniProtKB/Swiss-Prot for SPRED1 Gene
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).