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Aliases for SPRED1 Gene

Aliases for SPRED1 Gene

  • Sprouty-Related, EVH1 Domain Containing 1 2 3
  • Spred-1 3 4
  • HSpred1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 147 3
  • Suppressor Of Ras/MAPK Activation 3
  • Regulatory Subunit 147 2
  • Protein Phosphatase 1 2
  • PPP1R147 3
  • NFLS 3

External Ids for SPRED1 Gene

Previous GeneCards Identifiers for SPRED1 Gene

  • GC15P031440
  • GC15P036123
  • GC15P036260
  • GC15P036331
  • GC15P038545
  • GC15P015389

Summaries for SPRED1 Gene

Entrez Gene Summary for SPRED1 Gene

  • The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

GeneCards Summary for SPRED1 Gene

SPRED1 (Sprouty-Related, EVH1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SPRED1 include legius syndrome and neurofibromatosis, type 1. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include protein kinase binding and protein serine/threonine kinase inhibitor activity. An important paralog of this gene is ENAH.

UniProtKB/Swiss-Prot for SPRED1 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).

Gene Wiki entry for SPRED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED1 Gene

Genomics for SPRED1 Gene

Regulatory Elements for SPRED1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPRED1 Gene

38,252,087 bp from pter
38,357,249 bp from pter
105,163 bases
Plus strand

Genomic View for SPRED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED1 Gene

Proteins for SPRED1 Gene

  • Protein details for SPRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • B2RPJ8
    • Q05D53
    • Q8N256

    Protein attributes for SPRED1 Gene

    444 amino acids
    Molecular mass:
    50477 Da
    Quaternary structure:
    • Interacts with Ras. Interacts with TAOK2 and TESK1 (By similarity). Homodimer and heterodimer. Interacts with CAV1. Able to interact with SPRED2 to form heterodimers.
    • Sequence=AAH18015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPRED1 Gene

neXtProt entry for SPRED1 Gene

Proteomics data for SPRED1 Gene at MOPED

Post-translational modifications for SPRED1 Gene

Other Protein References for SPRED1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SPRED1 Gene

Domains & Families for SPRED1 Gene

Gene Families for SPRED1 Gene

Protein Domains for SPRED1 Gene


Suggested Antigen Peptide Sequences for SPRED1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 KBD domain.
  • Contains 1 KBD domain.
  • Contains 1 SPR (sprouty) domain.
  • Contains 1 WH1 domain.
genes like me logo Genes that share domains with SPRED1: view

Function for SPRED1 Gene

Molecular function for SPRED1 Gene

UniProtKB/Swiss-Prot Function:
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).

Gene Ontology (GO) - Molecular Function for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005173 stem cell factor receptor binding ISS --
GO:0005515 protein binding IPI 15231748
GO:0019901 protein kinase binding IPI 20736167
GO:0019902 phosphatase binding IDA 19389623
GO:0030291 protein serine/threonine kinase inhibitor activity ISS 20736167
genes like me logo Genes that share ontologies with SPRED1: view
genes like me logo Genes that share phenotypes with SPRED1: view

Animal Models for SPRED1 Gene

MGI Knock Outs for SPRED1:

Animal Model Products

miRNA for SPRED1 Gene

miRTarBase miRNAs that target SPRED1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SPRED1 Gene

Localization for SPRED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED1 Gene

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions.

Subcellular locations from

Jensen Localization Image for SPRED1 Gene COMPARTMENTS Subcellular localization image for SPRED1 gene
Compartment Confidence
nucleus 4
plasma membrane 3
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SPRED1: view

Pathways & Interactions for SPRED1 Gene

SuperPathways for SPRED1 Gene

Superpath Contained pathways
1 Interleukin receptor SHC signaling
2 Immune System
3 Signaling by GPCR
4 Developmental Biology
5 Kit Receptor Signaling Pathway
genes like me logo Genes that share pathways with SPRED1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000188 inactivation of MAPK activity ISS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with SPRED1: view

No data available for SIGNOR curated interactions for SPRED1 Gene

Drugs & Compounds for SPRED1 Gene

No Compound Related Data Available

Transcripts for SPRED1 Gene

Unigene Clusters for SPRED1 Gene

Sprouty-related, EVH1 domain containing 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPRED1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED1 Gene

No ASD Table

Relevant External Links for SPRED1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPRED1 Gene

mRNA expression in normal human tissues for SPRED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPRED1 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPRED1 Gene

SOURCE GeneReport for Unigene cluster for SPRED1 Gene Hs.525781

mRNA Expression by UniProt/SwissProt for SPRED1 Gene

Tissue specificity: Weakly expressed in embryonic cell line HEK293.
genes like me logo Genes that share expression patterns with SPRED1: view

Protein tissue co-expression partners for SPRED1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPRED1 Gene

Orthologs for SPRED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPRED1 35
  • 93.67 (n)
  • 93.44 (a)
  • 93 (a)
(Canis familiaris)
Mammalia SPRED1 35
  • 95.1 (n)
  • 95.48 (a)
  • 95 (a)
(Mus musculus)
Mammalia Spred1 35
  • 91.5 (n)
  • 93.45 (a)
Spred1 16
Spred1 36
  • 93 (a)
(Pan troglodytes)
Mammalia SPRED1 35
  • 99.85 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Spred1 35
  • 90.82 (n)
  • 92.1 (a)
(Monodelphis domestica)
Mammalia SPRED1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SPRED1 36
  • 73 (a)
(Gallus gallus)
Aves SPRED1 35
  • 83.09 (n)
  • 84.63 (a)
  • 79 (a)
(Anolis carolinensis)
Reptilia SPRED1 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spred1 35
  • 67.93 (n)
  • 71.21 (a)
(Danio rerio)
Actinopterygii spred1 35
  • 62.21 (n)
  • 63.75 (a)
spred1 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spred 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 36
  • 25 (a)
Species with no ortholog for SPRED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRED1 Gene

Gene Tree for SPRED1 (if available)
Gene Tree for SPRED1 (if available)

Paralogs for SPRED1 Gene

Paralogs for SPRED1 Gene

(3) SIMAP similar genes for SPRED1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPRED1: view

Variants for SPRED1 Gene

Sequence variations from dbSNP and Humsavar for SPRED1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs940026 -- 38,253,598(+) TAGCT(A/G)TTTCA intron-variant
rs954832 -- 38,326,056(-) aaact(C/T)gcctc intron-variant
rs955777 -- 38,256,801(+) tatgt(A/G)tatgt intron-variant
rs1357382 -- 38,307,724(+) ATTAT(G/T)GTAAC intron-variant
rs1357383 -- 38,257,841(+) ATTCC(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRED1 Gene

Variant ID Type Subtype PubMed ID
nsv832973 CNV Gain 17160897
nsv832974 CNV Loss 17160897
dgv2357n71 CNV Loss 21882294
nsv94413 CNV Loss 16902084
esv6112 CNV Gain 19470904
nsv510394 CNV Loss 20534489

Variation tolerance for SPRED1 Gene

Residual Variation Intolerance Score: 57.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPRED1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPRED1 Gene

Disorders for SPRED1 Gene

MalaCards: The human disease database

(12) MalaCards diseases for SPRED1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
legius syndrome
  • neurofibromatosis type 1-like syndrome
neurofibromatosis, type 1
  • type 1 neurofibromatosis
optic disk drusen
  • optic nerve head drusen
dyschromatosis universalis hereditaria
  • duh
  • von reklinghausen disease
- elite association


  • Neurofibromatosis 1-like syndrome (NFLS) [MIM:611431]: A disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity. {ECO:0000269 PubMed:17704776, ECO:0000269 PubMed:19443465, ECO:0000269 PubMed:20108422, ECO:0000269 PubMed:21089071}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SPRED1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPRED1: view

No data available for Genatlas for SPRED1 Gene

Publications for SPRED1 Gene

  1. TGF-beta modulates the functionality of tumor-infiltrating CD8+ T cells through effects on TCR signaling and Spred1 expression. (PMID: 19319531) di Bari M.G. … Sabzevari H. (Cancer Immunol. Immunother. 2009) 23 67
  2. Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome. (PMID: 19920235) Messiaen L. … Legius E. (JAMA 2009) 23 67
  3. Spred-2 steady-state levels are regulated by phosphorylation and Cbl- mediated ubiquitination. (PMID: 17094949) Lock P. … Stylli S.S. (Biochem. Biophys. Res. Commun. 2006) 23 67
  4. The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. (PMID: 16115197) Nonami A. … Yoshimura A. (Genes Cells 2005) 23 67
  5. MicroRNAs 206 and 21 cooperate to promote RAS-extracellular signal-regulated kinase signaling by suppressing the translation of RASA1 and SPRED1. (PMID: 25202123) Sharma S.B. … Ruppert J.M. (Mol. Cell. Biol. 2014) 67

Products for SPRED1 Gene

Sources for SPRED1 Gene

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