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Aliases for SPRED1 Gene

Aliases for SPRED1 Gene

  • Sprouty-Related, EVH1 Domain Containing 1 2 3
  • Spred-1 3 4
  • HSpred1 3 4
  • NFLS 3 6
  • Sprouty-Related, EVH1 Domain-Containing Protein 1 3
  • Protein Phosphatase 1, Regulatory Subunit 147 3
  • Suppressor Of Ras/MAPK Activation 3
  • Regulatory Subunit 147 2
  • Protein Phosphatase 1 2
  • PPP1R147 3

External Ids for SPRED1 Gene

Summaries for SPRED1 Gene

Entrez Gene Summary for SPRED1 Gene

  • The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinase in response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 to regulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS). [provided by RefSeq, Jul 2008]

GeneCards Summary for SPRED1 Gene

SPRED1 (Sprouty-Related, EVH1 Domain Containing 1) is a Protein Coding gene. Diseases associated with SPRED1 include legius syndrome and neurofibromatosis, type 1. Among its related pathways are Kit Receptor Signaling Pathway and Kit Receptor Signaling Pathway. GO annotations related to this gene include protein kinase binding and stem cell factor receptor binding. An important paralog of this gene is ENAH.

UniProtKB/Swiss-Prot for SPRED1 Gene

  • Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).

Gene Wiki entry for SPRED1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPRED1 Gene

Genomics for SPRED1 Gene

Genomic Location for SPRED1 Gene

Start:
38,252,326 bp from pter
End:
38,357,249 bp from pter
Size:
104,924 bases
Orientation:
Plus strand

Genomic View for SPRED1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPRED1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPRED1 Gene

Regulatory Elements for SPRED1 Gene

Proteins for SPRED1 Gene

  • Protein details for SPRED1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z699-SPRE1_HUMAN
    Recommended name:
    Sprouty-related, EVH1 domain-containing protein 1
    Protein Accession:
    Q7Z699
    Secondary Accessions:
    • B2RPJ8
    • Q05D53
    • Q8N256

    Protein attributes for SPRED1 Gene

    Size:
    444 amino acids
    Molecular mass:
    50477 Da
    Quaternary structure:
    • Interacts with Ras. Interacts with TAOK2 and TESK1 (By similarity). Homodimer and heterodimer. Interacts with CAV1. Able to interact with SPRED2 to form heterodimers.
    SequenceCaution:
    • Sequence=AAH18015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPRED1 Gene

neXtProt entry for SPRED1 Gene

Proteomics data for SPRED1 Gene at MOPED

Post-translational modifications for SPRED1 Gene

Other Protein References for SPRED1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPRED1 Gene

Domains for SPRED1 Gene

Protein Domains for SPRED1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SPRE1_HUMAN
Domain:
  • Contains 1 KBD domain.:
    • Q7Z699
  • Contains 1 SPR (sprouty) domain.:
    • Q7Z699
  • Contains 1 WH1 domain.:
    • Q7Z699
genes like me logo Genes that share domains with SPRED1: view

No data available for Gene Families for SPRED1 Gene

Function for SPRED1 Gene

Molecular function for SPRED1 Gene

UniProtKB/Swiss-Prot Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By similarity).

Gene Ontology (GO) - Molecular Function for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005173 stem cell factor receptor binding ISS --
GO:0005515 protein binding IPI 15231748
GO:0019901 protein kinase binding IPI 20736167
GO:0019902 phosphatase binding IDA 19389623
GO:0030291 protein serine/threonine kinase inhibitor activity ISS 20736167
genes like me logo Genes that share ontologies with SPRED1: view
genes like me logo Genes that share phenotypes with SPRED1: view

Animal Models for SPRED1 Gene

MGI Knock Outs for SPRED1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPRED1 Gene

Localization for SPRED1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPRED1 Gene

Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPRED1 Gene COMPARTMENTS Subcellular localization image for SPRED1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
cytoskeleton 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane --
GO:0005901 caveola IEA --
genes like me logo Genes that share ontologies with SPRED1: view

Pathways for SPRED1 Gene

genes like me logo Genes that share pathways with SPRED1: view

Pathways by source for SPRED1 Gene

Gene Ontology (GO) - Biological Process for SPRED1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity ISS --
GO:0007275 multicellular organismal development IEA --
GO:0009966 regulation of signal transduction --
GO:0010801 negative regulation of peptidyl-threonine phosphorylation IMP 20736167
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with SPRED1: view

Transcripts for SPRED1 Gene

Unigene Clusters for SPRED1 Gene

Sprouty-related, EVH1 domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPRED1 Gene

No ASD Table

Relevant External Links for SPRED1 Gene

GeneLoc Exon Structure for
SPRED1
ECgene alternative splicing isoforms for
SPRED1

Expression for SPRED1 Gene

mRNA expression in normal human tissues for SPRED1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPRED1 Gene

SOURCE GeneReport for Unigene cluster for SPRED1 Gene Hs.525781

mRNA Expression by UniProt/SwissProt for SPRED1 Gene

Q7Z699-SPRE1_HUMAN
Tissue specificity: Weakly expressed in embryonic cell line HEK293.
genes like me logo Genes that share expressions with SPRED1: view

Orthologs for SPRED1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPRED1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPRED1 36
  • 99.85 (n)
  • 100 (a)
SPRED1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPRED1 36
  • 93.67 (n)
  • 93.44 (a)
SPRED1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPRED1 36
  • 95.1 (n)
  • 95.48 (a)
SPRED1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spred1 36
  • 91.5 (n)
  • 93.45 (a)
Spred1 16
Spred1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPRED1 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPRED1 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spred1 36
  • 90.82 (n)
  • 92.1 (a)
chicken
(Gallus gallus)
Aves SPRED1 36
  • 83.09 (n)
  • 84.63 (a)
SPRED1 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPRED1 37
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spred1 36
  • 67.93 (n)
  • 71.21 (a)
zebrafish
(Danio rerio)
Actinopterygii spred1 36
  • 62.21 (n)
  • 63.75 (a)
spred1 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Spred 37
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10713 37
  • 25 (a)
OneToMany
Species with no ortholog for SPRED1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPRED1 Gene

ENSEMBL:
Gene Tree for SPRED1 (if available)
TreeFam:
Gene Tree for SPRED1 (if available)

Paralogs for SPRED1 Gene

Paralogs for SPRED1 Gene

Selected SIMAP similar genes for SPRED1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPRED1: view

Variants for SPRED1 Gene

Sequence variations from dbSNP and Humsavar for SPRED1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs940026 -- 38,253,598(+) TAGCT(A/G)TTTCA intron-variant
rs954832 -- 38,326,056(-) aaact(C/T)gcctc intron-variant
rs955777 -- 38,256,801(+) tatgt(A/G)tatgt intron-variant
rs1357382 -- 38,307,724(+) ATTAT(G/T)GTAAC intron-variant
rs1357383 -- 38,257,841(+) ATTCC(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPRED1 Gene

Variant ID Type Subtype PubMed ID
nsv832973 CNV Gain 17160897
nsv832974 CNV Loss 17160897
dgv2357n71 CNV Loss 21882294
nsv94413 CNV Loss 16902084
esv6112 CNV Gain 19470904
nsv510394 CNV Loss 20534489

Relevant External Links for SPRED1 Gene

HapMap Linkage Disequilibrium report
SPRED1
Human Gene Mutation Database (HGMD)
SPRED1
Locus Specific Mutation Databases (LSDB)
SPRED1

Disorders for SPRED1 Gene

(1) OMIM Diseases for SPRED1 Gene (609291)

UniProtKB/Swiss-Prot

SPRE1_HUMAN
  • Neurofibromatosis 1-like syndrome (NFLS) [MIM:611431]: A disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity. {ECO:0000269 PubMed:17704776, ECO:0000269 PubMed:19443465, ECO:0000269 PubMed:20108422, ECO:0000269 PubMed:21089071}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for SPRED1 Gene

Relevant External Links for SPRED1

Genetic Association Database (GAD)
SPRED1
Human Genome Epidemiology (HuGE) Navigator
SPRED1
genes like me logo Genes that share disorders with SPRED1: view

Publications for SPRED1 Gene

  1. Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome. (PMID: 19920235) Messiaen L. … Legius E. (JAMA 2009) 3 23 49
  2. The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. (PMID: 16115197) Nonami A. … Yoshimura A. (Genes Cells 2005) 3 4 23
  3. SPRED1 mutations (Legius syndrome): another clinically useful genotype for dissecting the neurofibromatosis type 1 phenotype. (PMID: 19443465) Spurlock G. … Upadhyaya M. (J. Med. Genet. 2009) 3 4 49
  4. Distinct requirements for the Sprouty domain for functional activity of Spred proteins. (PMID: 15683364) King J.A.J. … Hovens C.M. (Biochem. J. 2005) 3 4
  5. Spred-2 steady-state levels are regulated by phosphorylation and Cbl- mediated ubiquitination. (PMID: 17094949) Lock P. … Stylli S.S. (Biochem. Biophys. Res. Commun. 2006) 3 23

Products for SPRED1 Gene

Sources for SPRED1 Gene

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