SPRED1 Gene
protein-coding GIFtS: 61
GCID: GC15P038545
|
|
sprouty-related, EVH1 domain containing 1
| |
Aliases
for SPRED1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sprouty-Related, EVH1 Domain Containing 11 2 | | Spred-13 | | HSpred11 | | Sprouty-Related, EVH1 Domain-Containing Protein 12 | | NFLS2 5 | | Suppressor Of Ras/MAPK Activation2 | | FLJ339031 | | Spred-13 |
Export aliases for SPRED1 gene to outside databasesPrevious GC identifers: GC15P031440 GC15P036123 GC15P036260 GC15P036331 GC15P015389 |
Summaries
for SPRED1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPRED1:
The protein encoded by this gene is a member of the Sprouty family of proteins and is phosphorylated by tyrosine kinasein response to several growth factors. The encoded protein can act as a homodimer or as a heterodimer with SPRED2 toregulate activation of the MAP kinase cascade. Defects in this gene are a cause of neurofibromatosis type 1-likesyndrome (NFLS). (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: SPRE1_HUMAN, Q7Z699Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulateshematopoiesis of bone marrow (By similarity)
Gene Wiki entry for SPRED1
|
Genomic Views
for SPRED1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPRED1 gene promoter:
TBP AML1a FOXF2 MEF-2 POU6F1 (c2) MEF-2A POU2F1 POU2F1a aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPRED1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRED1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14SPRED1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P038545: view genomic region
(about GC identifiers)
Start:
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38,544,527 bp from pter |
End:
|
38,649,450 bp from pter |
Size:
|
104,924 bases |
Orientation:
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plus strand |
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Proteins
for SPRED1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPRE1_HUMAN, Q7Z699 (See
protein sequence)Recommended Name: Sprouty-related, EVH1 domain-containing protein 1 Size: 444 amino acids; 50477 Da
Subunit: Interacts with Ras. Interacts with TAOK2 and TESK1 (By similarity). Homodimer and heterodimer. Interacts withCAV1. Able to interact with SPRED2 to form heterodimers
Subcellular location: Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.Nucleus. Note=Localized in cholesterol-rich membrane raft/caveola fractions
Sequence caution: Sequence=AAH18015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
1 PDB 3D structure from  and Proteopedia  for SPRED1:3SYX (3D)
Secondary accessions: B2RPJ8 Q05D53 Q8N256Explore the universe of human proteins at neXtProt for SPRED1: NX_Q7Z699
Post-translational modifications:
Phosphorylated on tyrosine (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z699
SPRED1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689807.1
ENSEMBL proteins: ENSP00000299084 ENSP00000453680
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
SPRED1 for ontologies About GeneDecksing
SPRED1 Antibody Products:
Assay Products for SPRED1: |
Protein
Domains /
Families
for SPRED1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPRED1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z699ProtoNet protein and cluster: Q7Z699 1 Blocks protein family: IPB007875 Sprouty
UniProtKB/Swiss-Prot: SPRE1_HUMAN, Q7Z699Similarity: Contains 1 KBD domainSimilarity: Contains 1 SPR (sprouty) domainSimilarity: Contains 1 WH1 domain |
Function
for SPRED1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPRE1_HUMAN, Q7Z699Function: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulateshematopoiesis of bone marrow (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRED1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRED1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPRED1 (NM_152594) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRED1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRED1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRED1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
SPRED1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for SPRED1:
Animal Models:
Mouse knock-out Spred1tm1Hiin for SPRED1
8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Spred1):
SPRED1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPRED1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling events mediated by Stem cell factor receptor (c-Kit) | | | 2 | Jak-STAT signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for SPRED1
1 
Kegg Pathway (Kegg details for SPRED1):
SPRED1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPRED1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)
5/14 Interacting proteins for SPRED1 (Q7Z6991, 2, 3 ENSP000002990844) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000188 | inactivation of MAPK activity |
ISS | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
IMP | -- | | GO:0010923 | negative regulation of phosphatase activity |
IDA | 19389623 | | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator |
ISS | -- |
SPRED1 for ontologies About GeneDecksing
|
Drugs & Compounds
for SPRED1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPRED1
Search CenterWatch for drugs/clinical trials and news about SPRED1 / SPRE1
|
Transcripts
for SPRED1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPRED1 gene: NM_152594.2 Unigene Cluster for SPRED1: Sprouty-related, EVH1 domain containing 1 Hs.525781 [show with all ESTs]Unigene Representative Sequence: NM_1525943 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000299084(uc001zka.4) ENST00000561205 ENST00000561317
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRED1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRED1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPRED1 (NM_152594) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPRED1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRED1 |
Additional cDNA sequence: AK091222.1 AK095219.1 AL833561.1 AY299089.1 BC018015.1 BC137480.1 BC137481.1 BX538234.1 8 DOTS entries: DT.40106859 DT.91901809 DT.91874375 DT.100780094 DT.97778989 DT.75150117 DT.95179405 DT.91799898 24/112 AceView cDNA sequences (see all 112): AA970844 BE502726 BF512854 AA678672 AK095219 BM264115 AI392710 AW269789 BF592872 CK824662 BU753010 BC018015 AA565605 AL119827 BQ961421 BG548770 AI270700 AW612605 AI742347 BM837523 BM263824 N67355 AI889730 BQ026104
GeneLoc Exon Structure
|
Expression
for SPRED1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPRED1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SPRED1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPRED1
SOURCE GeneReport for Unigene cluster: Hs.525781
UniProtKB/Swiss-Prot: SPRE1_HUMAN, Q7Z699Tissue specificity: Weakly expressed in embryonic cell line HEK293
SABiosciences Expression via Pathway-Focused PCR Array including SPRED1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRED1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPRED1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRED1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRED1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRED1 |
Orthologs
for SPRED1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SPRED1 gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
SPRED11 |
sprouty-related, EVH1 domain containing 1 |
83.09(n)
84.63(a) |
|
423292 NM_001199709.1 NP_001186638.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SPRED16 |
-- |
74(a) |
1 ↔ 1 |
1(32584838-32606759) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
CF264274.12 |
-- |
75.62(n) |
|
CF264274.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
spred11 |
sprouty-related, EVH1 domain containing 1 |
62.21(n)
63.75(a) |
|
406513 NM_213232.1 NP_998397.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Spred1 |
Sprouty-related protein with EVH-1 domain |
52.56(n)
48.72(a) |
|
36643 NM_137144.3 NP_610988.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
unc-346 |
UNCoordinated family member (unc-34) |
10(a) |
1 → many |
V(982535-995405) |
ENSEMBL Gene Tree for SPRED1 (if available)
TreeFam Gene Tree for SPRED1 (if available) |
Paralogs
for SPRED1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPRED1 gene
- SPRED32 SPRED22
3 SIMAP similar genes for SPRED1 using alignment to 3 protein entries: SPRE1_HUMAN (see all proteins):SPRED2 EVL SPRED3
SPRED1 for paralogs About GeneDecksing
|
Genomic Variants
for SPRED1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPRED1 (38544527 - 38649450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SPRED1
1 CNV: 5777
1 Indel: 60173
Human Gene Mutation Database (HGMD): SPRED1
Locus Specific Mutation Databases (LSDB): SPRED1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRED1 |
|
Disorders
/ Diseases
for SPRED1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPRED1 for disorders About GeneDecksing
OMIM gene information: 609291
OMIM disorders: 611431
UniProtKB/Swiss-Prot: SPRE1_HUMAN, Q7Z699
Defects in SPRED1 are the cause of neurofibromatosis type 1-like syndrome (NFLS) [MIM:611431]. It is adisorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations ofneurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-likefacial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity
13  diseases for SPRED1: About MalaCardsneurofibromatosis optic disk drusen juvenile myelomonocytic leukemia legius syndrome
learning disability myelomonocytic leukemia noonan syndrome lipoma
hematopoiesis hepatocellular carcinoma leukemia carcinoma
neuronitis
2 diseases from the University of Copenhagen DISEASES database for SPRED1:Neurofibromatosis Optic disk drusen Human Genome Epidemiology (HuGE) Navigator: SPRED1 (5 documents)
Export disorders for SPRED1 gene to outside databases
|
Publications
for SPRED1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPRED1 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with SPRED1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. (PubMed id 16115197)1, 2, 9 Nonami A.... Yoshimura A. (2005)
- SPRED1 mutations (Legius syndrome): another clinicall y useful genotype for dissecting the neurofibromatosis type 1 phenotype. (PubMed id 19443465)1, 2 Spurlock G....Upadhyaya M. (2009)
- Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype. (PubMed id 17704776)1, 2 Brems H.... Legius E. (2007)
- Distinct requirements for the Sprouty domain for functional activity of Spred proteins. (PubMed id 15683364)1, 2 King J.A.J.... Hovens C.M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Clinical and mutational spectrum of neurofibromatosis type 1-like syndrome. (PubMed id 19920235)1, 9 Messiaen L....Legius E. (2009)
- Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. (PubMed id 17094949)1, 9 Lock P....Stylli S.S. (2006)
- A shared molecular mechanism underlies the human rasop athies Legius syndrome and Neurofibromatosis-1. (PubMed id 22751498)1 Stowe I.B....McCormick F. (2012)
- Protein phosphatase 1a interacting proteins in the hum an brain. (PubMed id 22321011)1 Esteves S.L....da Cruz e Silva E.F. (2012)
- Sprouty2 and Spred1-2 proteins inhibit the activation of the ERK pathway elicited by cyclopentenone prostanoids. (PubMed id 21364986)1 GarcA-a-DomA-nguez C.A....Rojas J.M. (2011)
|
External Searches for SPRED1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPRED1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPRED1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPRED1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPRED1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SPRED1 gene:
Search GeneIP for patents involving SPRED1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPRED1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for SPRED1 | | OriGene shRNA RFP for SPRED1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPRED1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPRED1 | | | OriGene Protein Over-expression Lysate for SPRED1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPRED1 | | OriGene 3'-UTR Clone for SPRED1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPRED1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPRED1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPRED1 | | OriGene Custom Protein Services for SPRED1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPRED1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPRED1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPRED1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPRED1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPRED1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPRED1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for SPRED1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | SPRED1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPRED1 |
|  |  |  | | | | ThermoFisher Antibodies for SPRED1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPRED1 |
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