SPR Gene
protein-coding GIFtS: 67
GCID: GC02P073026
|
|
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
| |
Aliases
for SPR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Sepiapterin Reductase (7,8-Dihydrobiopterin:NADP+ Oxidoreductase)1 2 | | SDR38C11 2 | | EC 1.1.1.1533 8 | | Sepiapterin Reductase2 | | Short Chain Dehydrogenase/Reductase Family 38C, Member 12 |
Export aliases for SPR gene to outside databasesPrevious GC identifers: GC02P073124 GC02P073325 GC02P073089 GC02P072968 GC02P072850 |
Summaries
for SPR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SPR:
This gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and isimportant in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystoniadue to sepiaterin reductase deficiency. A pseudogene has been identified on chromosome 1. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: SPRE_HUMAN, P35270Function: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form5,6,7,8-tetrahydrobiopterin
Gene Wiki entry for SPR
|
Genomic Views
for SPR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPR gene promoter:
N-Myc TBP C/EBPbeta PPAR-gamma1 PPAR-gamma2 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p14-p12 Ensembl cytogenetic band: 2p13.2 HGNC cytogenetic band: 2p14-p12SPR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P073026: view genomic region
(about GC identifiers)
Start:
|
73,114,489 bp from pter |
End:
|
73,119,289 bp from pter |
Size:
|
4,801 bases |
Orientation:
|
plus strand |
|
Proteins
for SPR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPRE_HUMAN, P35270 (See
protein sequence)Recommended Name: Sepiapterin reductase Size: 261 amino acids; 28048 Da
Subunit: Homodimer
Subcellular location: Cytoplasm
1 PDB 3D structure from  and Proteopedia  for SPR:1Z6Z (3D)
Secondary accessions: A8K741 D6W5H2 Q53GI9 Q9UBB1Explore the universe of human proteins at neXtProt for SPR: NX_P35270
Post-translational modifications:
In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P35270
2 DME Specific Peptides for SPR (P35270)
SPR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003115.1
ENSEMBL proteins: ENSP00000234454 Reactome Protein details: P35270
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
SPR for ontologies About GeneDecksing
SPR Antibody Products:
Assay Products for SPR: |
Protein
Domains /
Families
for SPR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPR for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P35270ProtoNet protein and cluster: P35270 1 Blocks protein family: IPB002198 Short-chain dehydrogenase/reductase SDR
UniProtKB/Swiss-Prot: SPRE_HUMAN, P35270Similarity: Belongs to the sepiapterin reductase family |
Function
for SPR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPRE_HUMAN, P35270Function: Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form5,6,7,8-tetrahydrobiopterinCatalytic activity: L-erythro-7,8-dihydrobiopterin + NADP(+) = sepiapterin + NADPHCatalytic activity: L-erythro-tetrahydrobiopterin + 2 NADP(+) = 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPHBiophysicochemical properties: Kinetic parameters: KM=14.3 uM for sepiapterin; KM=10 uM for NADPH; Genatlas biochemistry entry for SPR:sepiapterin reductase,catalyzing the final step of tetrahydrobiopterin (BH4) synthesis,cofactor for aromatic aminoacidhydroxylase and nitric oxid synthase
Enzyme Number (IUBMB): EC 1.1.1.1531 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPR (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPR (NM_003124) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPR |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
SPR for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for SPR:
Animal Models:
Mouse knock-outs for SPR: Sprtm1Lex Sprtm1Spo
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Spr):
SPR for phenotypes About GeneDecksing
|
Pathways & Interactions
for SPR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism of nitric oxide | | | 2 | Metabolism | | | 3 | Folate biosynthesis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for SPR
4 
Reactome Pathways for SPR
2 
Kegg Pathways (Kegg details for SPR):
SPR for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPR
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/7 Interacting proteins for SPR (P352702, 3 ENSP000002344544) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
SPR for ontologies About GeneDecksing
|
Drugs & Compounds
for SPR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
SPR for compounds About GeneDecksing
 Browse Tocris compounds for SPR
9 HMDB Compounds for SPR About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Dihydrobiopterin | (S-(R*,S*))-2-amino-6-(1,2-dihydroxypropyl)-7,8-dihydro-4(1H)-Pteridinone (see all 15) | 6779-87-9 | 3888618 | | Tetrahydrobiopterin | (1R,2S)-(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)-1,2-propandiol (see all 11) | 17528-72-2 | 9165069 | | 1-hydroxy-2-Oxopropyl tetrahydropterin | | -- | -- | | 6-Lactoyltetrahydropterin | 6-Lactoyl tetrahydropterin (see all 4) | 33405-80-0 | -- | | Dyspropterin | 6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin (see all 5) | 89687-39-8 | -- | | NADP | Adenine-nicotinamide dinucleotide phosphate (see all 18) | 53-59-8 | -- | | NADPH | 2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23) | 53-57-6 | -- | | Sapropterin | (6R)-5,6,7,8-Tetrahydro-L-biopterin (see all 11) | 62989-33-7 | -- | | Sepiapterin | L-sepiapterin (see all 8) | 17094-01-8 | -- |
4 DrugBank Compounds for SPR About this table
10/17 Novoseek chemical compound relationships for SPR gene (see all 17) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sepiapterin |
99.1 |
137 |
2154472 (3), 1883349 (3), 1544933 (3), 17074599 (3) (see all 70) |
| 6-pyruvoyltetrahydropterin |
97.4 |
22 |
2154472 (3), 16917893 (2), 12003346 (1), 15197144 (1) (see all 17) |
| tetrahydrobiopterin |
95.1 |
39 |
1883349 (2), 8137944 (2), 12604243 (2), 11592814 (2) (see all 27) |
| dihydropteridine |
92.5 |
9 |
16917893 (2), 12003346 (1), 2039522 (1), 11902126 (1) (see all 7) |
| dihydroneopterin triphosphate |
89.1 |
1 |
1797835 (1) |
| pterin |
85 |
4 |
1544933 (1), 16532389 (1), 17074599 (1) |
| gtp |
79.9 |
41 |
2154472 (2), 19234759 (2), 16917893 (2), 12003346 (1) (see all 22) |
| n-acetylserotonin |
79.3 |
5 |
18511317 (2), 1544933 (1), 8569700 (1), 12604243 (1) |
| pteridine |
74.4 |
1 |
2039522 (1) |
| phenylalanine |
61.7 |
4 |
12414107 (1), 17690069 (1), 19234759 (1) |
Search CenterWatch for drugs/clinical trials and news about SPR / SPRE
|
Transcripts
for SPR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPR gene: NM_003124.4 Unigene Cluster for SPR: Sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) Hs.301540 [show with all ESTs]Unigene Representative Sequence: NM_0031242 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000234454(uc002sik.2) ENST00000498749
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPR (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPR (NM_003124) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPR |
Additional cDNA sequence: AK222942.1 AK291856.1 AK299712.1 BC017310.2 M76231.1 S71376.1 7 DOTS entries: DT.444056 DT.95218055 DT.91929740 DT.120976166 DT.120976161 DT.100790157 DT.121357073 24/181 AceView cDNA sequences (see all 181): AW950012 CA427814 AI858977 CB160993 BU185346 S71376 BM982265 BM714162 BM976526 CD673155 M76231 BQ681529 AA344925 CA455162 BQ680362 AU142468 BM560296 BF182777 BQ926641 AA399128 BC017310 BX413078 BM817436 NM_003124
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SPR About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for SPR
|
Expression
for SPR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCAGCCCA
About this image
See SPR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPR
SOURCE GeneReport for Unigene cluster: Hs.301540
SABiosciences Custom PCR Arrays for SPR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPR |
Orthologs
for SPR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for SPR gene from 6/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Spr1 , 5 |
sepiapterin reductase1, 5 |
79.2(n)1
74.81(a)1 |
|
6 (37.15 cM)5
207511 NM_011467.21 NP_035597.21
851336785 |
chicken
(Gallus gallus) |
Aves |
SPR1 |
sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) |
68.12(n)
65.08(a) |
|
425255 XM_423038.3 XP_423038.1 |
lizard
(Anolis carolinensis) |
Reptilia |
SPR6 |
-- |
65(a) |
1 ↔ 1 |
GL343632.1(40293-42818) |
African clawed frog
(Xenopus laevis) |
Amphibia |
spr-prov2 |
sepiapterin reductase (7,8-dihydrobiopterinNADP+ oxidoreductase) |
78.01(n) |
|
BC043999.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
spra1 |
sepiapterin reductase a |
60.39(n)
52.55(a) |
|
554136 NM_001024430.1 NP_001019601.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Sptr1 , 3 |
sepiapterin reductase3
Sepiapterin reductase1 |
33(a)3
46.75(n)1
34.66(a)1 |
|
7E113
317811 NM_167157.11 NP_727265.11 |
ENSEMBL Gene Tree for SPR (if available)
TreeFam Gene Tree for SPR (if available) |
Paralogs
for SPR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPR gene
SPR for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SPR
PGOHUM00000244737
|
Genomic Variants
for SPR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPR (73114489 - 73119289 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPR: --
Human Gene Mutation Database (HGMD): SPR
Locus Specific Mutation Databases (LSDB): SPR
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPR |
|
Disorders
/ Diseases
for SPR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPR for disorders About GeneDecksing
OMIM gene information: 182125
OMIM disorders: 612716
UniProtKB/Swiss-Prot: SPRE_HUMAN, P35270
Defects in SPR are the cause of dystonia DOPA-responsive due to sepiapterin reductase deficiency (DRDSPRD)[MIM:612716]. In the majority of cases, patients manifest progressive psychomotor retardation, dystonia andspasticity. Cognitive anomalies are also often present. The disease is due to severe dopamine and serotonindeficiencies in the central nervous system caused by a defect in BH4 synthesis. Dystonia is defined by the presence ofsustained involuntary muscle contractions, often leading to abnormal postures
15  diseases for SPR: About MalaCardsdopa-responsive dystonia sepiapterin reductase deficiency dihydropteridine reductase deficiency hyperphenylalaninemia
tetrahydrobiopterin deficiency spina bifida hypersomnia cervical dystonia
phenylketonuria parkinson's disease bipolar disorder neurologic diseases
spasticity cervicitis neuroblastoma
2 diseases from the University of Copenhagen DISEASES database for SPR:Phenylketonuria Bladder transitional cell carcinoma 3 Novoseek disease relationships for SPR gene About this table
Human Genome Epidemiology (HuGE) Navigator: SPR (30 documents)
Export disorders for SPR gene to outside databases
|
Publications
for SPR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPR gene, integrated from 9 sources (see all 98):
(articles sorted by number of sources associating them with SPR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and sequencing of cDNA encoding human sepiapterin reductase -- an enzyme involved in tetrahydrobiopterin biosynthesis. (PubMed id 1883349)1, 2, 3, 9 Ichinose H.... Nagatsu T. (1991)
- Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca2+/calmodulin-dependent protein kinase II. (PubMed id 11825621)1, 2, 9 Fujimoto K.... Katoh S. (2002)
- Genomic organization and chromosomal localization of the human sepiapterin reductase gene. (PubMed id 9792819)1, 2, 9 Ohye T.... Ichinose H. (1998)
- Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine-neurotransmitter deficiency without hyperphenylalaninemia. (PubMed id 11443547)1, 2, 9 Bonafe L.... Blau N. (2001)
- Detection of a novel sepiapterin reductase mRNA: assay of mRNA in various cells and tissues of various species. (PubMed id 8440319)1, 2, 9 Maier J.... Ziegler I. (1993)
- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sepiapterin reductase expression is increased in Parkinson's disease brain tissue. (PubMed id 17270157)1, 9 Tobin J.E....Myers R.H. (2007)
- Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. (PubMed id 19415819)1, 9 McHugh P.C....Kennedy M.R. (2009)
- The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations. (PubMed id 16443856)1, 9 Sharma M....Gasser T. (2006)
|
External Searches for SPR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SPR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPR | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/SPR |
|
| | |
About This Section
| Patent Information for SPR gene:
Search GeneIP for patents involving SPR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for SPR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for SPR | | OriGene shRNA RFP for SPR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPR | | | OriGene Protein Over-expression Lysate for SPR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPR | | OriGene 3'-UTR Clone for SPR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for SPR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPR | | OriGene Custom Protein Services for SPR | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPR |
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| | | | Search Tocris compounds for SPR |
| |  |  |  |  | | | | | | Recombinant Protein for SPR |
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 | | | SPR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPR |
|  |  |  | | | | ThermoFisher Antibodies for SPR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPR |
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