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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPPL3 Gene

protein-coding   GIFtS: 47
GCID: GC12M121231

Signal Peptide Peptidase Like 3

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Signal Peptide Peptidase Like 31 2     SPP-Like 32 3
Intramembrane Protease 21 2 3     MDHV18872
Presenilin-Like Protein 41 2 3     PRO43322
IMP22 3 5     Signal Peptide Peptidase-Like 32
Presenilin Homologous Protein 12 3     EC 3.4.23.-3
PSH12 3     IMP-23
PSL42 3     

External Ids:    HGNC: 304241   Entrez Gene: 1216652   Ensembl: ENSG000001578377   OMIM: 6082405   UniProtKB: Q8TCT63   

Export aliases for SPPL3 gene to outside databases

Previous GC identifers: GC12P119943 GC12M120799 GC12M120983 GC12M119612 GC12M119663 GC12M121201 GC12M118210 GC12M121202 GC12M121210


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPPL3 Gene: 
SPPL3 (signal peptide peptidase like 3) is a protein-coding gene. Diseases associated with SPPL3 include malaria. GO annotations related to this gene include protein homodimerization activity and aspartic endopeptidase activity, intramembrane cleaving. An important paralog of this gene is HM13.

UniProtKB/Swiss-Prot: SPPL3_HUMAN, Q8TCT6
Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
hydrophobic plane of the membrane

Gene Wiki entry for SPPL3 (UNQ1887) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009775.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPPL3 gene promoter:
         STAT1   p53   STAT1beta   CUTL1   STAT1alpha   POU2F1   POU2F1a   FOXO4   AP-2beta   ZID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SPPL3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPPL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.31   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.31

SPPL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPPL3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M121231:  view genomic region     (about GC identifiers)

Start:
121,200,313 bp from pter      End:
121,342,174 bp from pter
Size:
141,862 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPPL3_HUMAN, Q8TCT6 (See protein sequence)
Recommended Name: Signal peptide peptidase-like 3  
Size: 385 amino acids; 42563 Da
Subunit: Monomer. Homodimer
Subcellular location: Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane
protein. Note=Restricted to the early secretory compartment
Sequence caution: Sequence=BAC11290.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q3MJ04 Q8TAU4 Q96DD9
Alternative splicing: 3 isoforms:  Q8TCT6-1   Q8TCT6-2   Q8TCT6-3   

Explore the universe of human proteins at neXtProt for SPPL3: NX_Q8TCT6

Explore proteomics data for SPPL3 at MOPED 

Post-translational modifications:

  • UniProtKB: Not glycosylated
  • View neXtProt modification sites for NX_Q8TCT6

  • SPPL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPPL3 Protein Expression
    REFSEQ proteins: NP_620584.2  
    ENSEMBL proteins: 
     ENSP00000288680   ENSP00000442484   ENSP00000437603   ENSP00000439390   ENSP00000446088  
     ENSP00000444821  

    Human Recombinant Protein Products for SPPL3: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005791rough endoplasmic reticulum IDA15998642
    GO:0016021integral to membrane ----
    GO:0030660Golgi-associated vesicle membrane IDA16829952
    GO:0071458integral to cytosolic side of endoplasmic reticulum membrane IDA15385547
    GO:0071556integral to lumenal side of endoplasmic reticulum membrane IDA15385547

    SPPL3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006639 Peptidase_A22
     IPR007369 Peptidase_A22B_SPP

    Graphical View of Domain Structure for InterPro Entry Q8TCT6

    ProtoNet protein and cluster: Q8TCT6

    1 Blocks protein domain: IPB006639 Presenilin signal peptide peptidase

    UniProtKB/Swiss-Prot: SPPL3_HUMAN, Q8TCT6
    Domain: The PAL motif is required for normal active site conformation (By similarity). The catalytic domains
    embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it
    is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP
    Domain: The first transmembrane domain may act as a type I signal anchor
    Similarity: Belongs to the peptidase A22B family


    SPPL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPPL3_HUMAN, Q8TCT6
    Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
    hydrophobic plane of the membrane
    Enzyme regulation: Its proteolytic activity is blocked by signal peptide peptidase (SPP) inhibitors

         Enzyme Number (IUBMB): EC 3.4.23.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity ----
    GO:0042500aspartic endopeptidase activity, intramembrane cleaving IMP16873890
    GO:0042803protein homodimerization activity IDA15385547
         
    SPPL3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Sppl3):
     behavior/neurological  growth/size  reproductive system 

    SPPL3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPPL3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPPL3 
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    miRNA
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    miRTarBase miRNAs that target SPPL3:
    hsa-mir-18a (MIRT004384)

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    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate SPPL3 (see all 84):
    hsa-miR-124* hsa-miR-582-3p hsa-miR-300 hsa-miR-938 hsa-miR-605 hsa-miR-374a hsa-miR-3138 hsa-miR-3653
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPPL3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPPL3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SPPL3 (ENSP000002886804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006509NOT membrane protein ectodomain proteolysis IMP16829952

    SPPL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPPL3

    Search CenterWatch for drugs/clinical trials and news about SPPL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPPL3 gene: 
    NM_139015.4  

    Unigene Cluster for SPPL3:

    Signal peptide peptidase like 3
    Hs.507087  [show with all ESTs]
    Unigene Representative Sequence: NM_139015
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000353487(uc001tzc.3 uc001tzd.3) ENST00000392495 ENST00000545209
    ENST00000536996 ENST00000543608 ENST00000543854 ENST00000543181 ENST00000534966
    ENST00000540091
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    hsa-miR-124* hsa-miR-582-3p hsa-miR-300 hsa-miR-938 hsa-miR-605 hsa-miR-374a hsa-miR-3138 hsa-miR-3653
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    Additional mRNA sequence: 

    AB252457.1 AF086117.1 AJ345030.1 AJ420898.1 AK074916.1 AK223590.1 AK291161.1 AL110147.1 
    AY169313.1 AY358767.1 BC009551.1 BC025781.1 BC073910.1 BC101625.1 BC101627.1 BX640849.1 

    12 DOTS entries:

    DT.451557  DT.100680256  DT.121175215  DT.100796289  DT.91751925  DT.100665379  DT.100796290  DT.100796294 
    DT.91702594  DT.95098244  DT.97845833  DT.91945092 

    4 AceView cDNA sequences:

    BC011943 BG260754 AK097149 BG339618 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPPL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCACCCAGA
    SPPL3 Expression
    About this image


    See SPPL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPPL3

    SOURCE GeneReport for Unigene cluster: Hs.507087

    UniProtKB/Swiss-Prot: SPPL3_HUMAN, Q8TCT6
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPPL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPPL3 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sppl31 , 5 signal peptide peptidase 31, 5 91.23(n)1
    100(a)1
      5 (55.99 cM)5
    745851  NM_029012.21  NP_083288.21 
     1150111375 
    chicken
    (Gallus gallus)
    Aves LOC4169681 signal peptide peptidase-like 3-like 84.29(n)
    98.18(a)
      416968  XM_415261.3  XP_415261.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPPL36
    signal peptide peptidase like 3
    97(a)
    1 ↔ 1
    GL343338.1(203364-228851)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC529752 similar to presenilin-like protein 4 79.81(n)    BC045217.1 
    zebrafish
    (Danio rerio)
    Actinopterygii sppl31 signal peptide peptidase 3 77.87(n)
    94.75(a)
      548609  NM_001015068.1  NP_001015068.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG173701 , 3 CG173701 65(a)3
    61.61(n)1
    67.48(a)1
      96F63
    431281  NM_170244.11  NP_733123.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKL100C6
    Putative protein of unknown function with similari...
    14(a)
    1 → many
    XI(253697-255460)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SPPL11 signal peptide peptidase-like 1 46.08(n)
    37.65(a)
      829478  NM_119495.2  NP_567918.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g03931001 hypothetical protein 45.69(n)
    37.92(a)
      4348538  NM_001071053.1  NP_001064518.1 


    ENSEMBL Gene Tree for SPPL3 (if available)
    TreeFam Gene Tree for SPPL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPPL3 gene
    HM132  SPPL2C2  SPPL2A2  

    SPPL3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPPL3
    PGOHUM00000235097


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3225 SNPs in SPPL3 are shown (see all 3225)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862559791,2
    Cuntested1121247974(+) GAGACA/GGGGTC 1 -- int10--------
    rs1131083101,2
    C--118301219(+) CACAT-/ACACAC
            
    ACACA
    1 -- int11Minor allele frequency- ACACAC:0.50CSA 2
    rs5800761,2
    C,F,H--121199842(+) CACACT/CAGGCT 1 -- int112Minor allele frequency- C:0.06MN NS EA NA WA 1496
    rs1900699051,2
    --121199872(+) ATATCG/TTCATT 1 -- int10--------
    rs5802401,2
    C,F,A,H--121199903(+) GTTATG/TAAAAA 1 -- int120Minor allele frequency- N:0.00EA NA MN WA CSA 823
    rs775938621,2
    C--121199934(+) CAGTCT/GCTTTG 1 -- int11Minor allele frequency- G:0.01EA 120
    rs1927084341,2
    --121199975(+) AGGAAA/TCTGCT 1 -- int10--------
    rs1472295931,2
    --121200065(+) TAAGAA/GGCGGA 1 -- int10--------
    rs1143545471,2
    C,F--121200067(+) AGAGGC/GGGACC 1 -- int11Minor allele frequency- G:0.04WA 118
    rs1389252051,2
    --121200069(+) AGGCGC/GACCTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPPL3 (121200313 - 121342174 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SPPL3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2591284CNV Deletion19546169
    esv2672947CNV Deletion23128226
    esv1190904CNV Deletion17803354
    esv2746478CNV Deletion23290073
    esv1624453CNV Insertion17803354
    nsv908CNV Insertion18451855
    esv23186CNV Loss19812545
    nsv521928CNV Gain19592680
    nsv899559CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608240    OMIM disorders: --

    2 diseases for SPPL3:    About MalaCards
    malaria    


    SPPL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPPL3
    Human Genome Epidemiology (HuGE) Navigator: SPPL3 (3 documents)

    Export disorders for SPPL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPPL3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with SPPL3)
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    1. Novel class of polytopic proteins with domains associated with putative protease activity. (PubMed id 12139484)1, 2, 3 Grigorenko A.P.... Rogaev E.I. (2002)
    2. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. (PubMed id 16873890)1, 2, 9 Nyborg A.C....Golde T.E. (2006)
    3. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. (PubMed id 15385547)1, 2, 9 Friedmann E.... Martoglio B. (2004)
    4. Genome-wide association studies in an isolated founde r population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (2009)
    5. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. (PubMed id 16829952)1, 2 Friedmann E....Martoglio B. (2006)
    6. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. (PubMed id 15998642)1, 2 Krawitz P....Haass C. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Identification of signal peptide peptidase, a presenilin-type aspartic protease. (PubMed id 12077416)1, 2 Weihofen A.... Martoglio B. (2002)
    10. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. (PubMed id 17965014)1, 9 Martin L....Haass C. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121665 HGNC: 30424 AceView: SPPL3.1 Ensembl:ENSG00000157837 euGenes: HUgn121665
    ECgene: SPPL3 H-InvDB: SPPL3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPPL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPPL3 gene:
    Search GeneIP for patents involving SPPL3

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