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Aliases for SPPL2C Gene

Aliases for SPPL2C Gene

  • Signal Peptide Peptidase Like 2C 2 3
  • Intramembrane Protease 5 2 3 4
  • Imp5 3 4 6
  • SPP-Like 2C 3 4
  • IMP-5 3 4
  • Signal Peptide Peptidase-Like 2C 3
  • EC 3.4.23.- 4
  • SPPL2c 4

External Ids for SPPL2C Gene

Previous GeneCards Identifiers for SPPL2C Gene

  • GC17P043923

Summaries for SPPL2C Gene

GeneCards Summary for SPPL2C Gene

SPPL2C (Signal Peptide Peptidase Like 2C) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and aspartic-type endopeptidase activity. An important paralog of this gene is SPPL3.

UniProtKB/Swiss-Prot for SPPL2C Gene

  • Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPPL2C Gene

Genomics for SPPL2C Gene

Genomic Location for SPPL2C Gene

45,844,835 bp from pter
45,847,072 bp from pter
2,238 bases
Plus strand

Genomic View for SPPL2C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPPL2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPPL2C Gene

No data available for Regulatory Elements for SPPL2C Gene

Proteins for SPPL2C Gene

  • Protein details for SPPL2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Signal peptide peptidase-like 2C
    Protein Accession:
    Secondary Accessions:
    • Q8TC67
    • Q8WVZ6

    Protein attributes for SPPL2C Gene

    684 amino acids
    Molecular mass:
    74503 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPPL2C Gene

Proteomics data for SPPL2C Gene at MOPED

Post-translational modifications for SPPL2C Gene

Other Protein References for SPPL2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPPL2C Gene

Domains for SPPL2C Gene

Protein Domains for SPPL2C Gene

Suggested Antigen Peptide Sequences for SPPL2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8IUH8
  • The PAL motif is required for normal active site conformation (By similarity). The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.
  • Contains 1 PA (protease associated) domain.
  • Belongs to the peptidase A22B family.
genes like me logo Genes that share domains with SPPL2C: view

No data available for Gene Families for SPPL2C Gene

Function for SPPL2C Gene

Molecular function for SPPL2C Gene

UniProtKB/Swiss-Prot Function: Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane.

Enzyme Numbers (IUBMB) for SPPL2C Gene

Gene Ontology (GO) - Molecular Function for SPPL2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004190 aspartic-type endopeptidase activity IEA --
GO:0042803 protein homodimerization activity IDA 15385547
genes like me logo Genes that share ontologies with SPPL2C: view

Animal Model Products

CRISPR Products

miRNA for SPPL2C Gene

miRTarBase miRNAs that target SPPL2C

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPPL2C

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPPL2C Gene

Localization for SPPL2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPPL2C Gene

Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SPPL2C Gene COMPARTMENTS Subcellular localization image for SPPL2C gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SPPL2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IDA 16829952
GO:0016021 integral component of membrane --
GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IDA 15385547
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IDA 15385547
genes like me logo Genes that share ontologies with SPPL2C: view

Pathways for SPPL2C Gene

SuperPathways for SPPL2C Gene

No Data Available

Interacting Proteins for SPPL2C Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000332488 for SPPL2C Gene via STRING

Gene Ontology (GO) - Biological Process for SPPL2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006509 NOT membrane protein ectodomain proteolysis IMP 17965014
GO:0031293 NOT membrane protein intracellular domain proteolysis IMP 16829952
genes like me logo Genes that share ontologies with SPPL2C: view

No data available for Pathways by source for SPPL2C Gene

Transcripts for SPPL2C Gene

mRNA/cDNA for SPPL2C Gene

(2) Additional mRNA sequences :
(23) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPPL2C Gene

Signal peptide peptidase like 2C:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPPL2C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPPL2C Gene

No ASD Table

Relevant External Links for SPPL2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPPL2C Gene

mRNA expression in normal human tissues for SPPL2C Gene

mRNA differential expression in normal tissues according to GTEx for SPPL2C Gene

This gene is overexpressed in Testis (44.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPPL2C Gene

SOURCE GeneReport for Unigene cluster for SPPL2C Gene Hs.144491

mRNA Expression by UniProt/SwissProt for SPPL2C Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with SPPL2C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SPPL2C Gene

Orthologs for SPPL2C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SPPL2C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPPL2C 35
  • 98.93 (n)
  • 98.83 (a)
  • 99 (a)
(Bos Taurus)
Mammalia SPPL2C 35
  • 81.33 (n)
  • 75 (a)
  • 74 (a)
(Canis familiaris)
Mammalia SPPL2C 35
  • 79.48 (n)
  • 72.89 (a)
  • 73 (a)
(Mus musculus)
Mammalia Sppl2c 35
  • 76.05 (n)
  • 69.78 (a)
Sppl2c 16
Sppl2c 36
  • 69 (a)
(Monodelphis domestica)
Mammalia SPPL2C 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia SPPL2C 36
  • 38 (a)
(Rattus norvegicus)
Mammalia Sppl2c 35
  • 76.88 (n)
  • 72.31 (a)
(Gallus gallus)
Aves SPPL2B 36
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
(Danio rerio)
Actinopterygii sppl2 36
  • 47 (a)
(Caenorhabditis elegans)
Secernentea imp-1 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 16 (a)
Species with no ortholog for SPPL2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPPL2C Gene

Gene Tree for SPPL2C (if available)
Gene Tree for SPPL2C (if available)

Paralogs for SPPL2C Gene

Paralogs for SPPL2C Gene

Selected SIMAP similar genes for SPPL2C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPPL2C: view

Variants for SPPL2C Gene

Sequence variations from dbSNP and Humsavar for SPPL2C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_038048 -
VAR_038049 -
VAR_038050 -
VAR_038051 -
VAR_038052 -

Relevant External Links for SPPL2C Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPPL2C Gene

Disorders for SPPL2C Gene

No disorders were found for SPPL2C Gene.

No data available for UniProtKB/Swiss-Prot for SPPL2C Gene

Publications for SPPL2C Gene

  1. Novel class of polytopic proteins with domains associated with putative protease activity. (PMID: 12139484) Grigorenko A.P. … Rogaev E.I. (Biokhimiia 2002) 2 3 4
  2. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. (PMID: 15385547) Friedmann E. … Martoglio B. (J. Biol. Chem. 2004) 3 4
  3. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. (PMID: 16829952) Friedmann E. … Martoglio B. (Nat. Cell Biol. 2006) 3 4
  4. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. (PMID: 17965014) Martin L. … Haass C. (J. Biol. Chem. 2008) 3 23
  5. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. (PMID: 21738487) Do C.B. … Eriksson N. (PLoS Genet. 2011) 3

Products for SPPL2C Gene

Sources for SPPL2C Gene

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