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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPPL2B Gene

protein-coding   GIFtS: 48
GCID: GC19P002328

signal peptide peptidase like 2B
 Explore 3 diseases affiliated with
SPPL2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPPL2B    

Aliases
for SPPL2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Signal Peptide Peptidase Like 2B1 2     IMP-42 3
IMP41 2 3 5     PSH42 3
PSL11 2 3     SPP-Like 2B2 3
KIAA15321 3 5     Signal Peptide Peptidase-Like 2B2
Intramembrane Protease 42 3     EC 3.4.23.-3
Presenilin Homologous Protein 42 3     SPPL2b3
Presenilin-Like Protein 12 3     SNPPL2B5

External Ids:    HGNC: 306271   Entrez Gene: 569282   Ensembl: ENSG000000052067   OMIM: 6082395   UniProtKB: Q8TCT73   

Export aliases for SPPL2B gene to outside databases

Previous GC identifers: GC19P002391 GC19P002268 GC19P002279 GC19P002099


Summaries
for SPPL2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPPL2B:
This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with
two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes,
lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the
intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SPP2B_HUMAN, Q8TCT7
Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the
anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling
to the nucleus. May play a role in the regulation of innate and adaptive immunity

Gene Wiki entry for SPPL2B


Genomic Views
for SPPL2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPPL2B gene promoter:
         GR   Sp1   GR-alpha   STAT5A   E47   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPPL2B promoter sequence
   Search SABiosciences Chromatin IP Primers for SPPL2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPPL2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

SPPL2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPPL2B gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P002328:  view genomic region     (about GC identifiers)

Start:
 2,328,617 bp from pter      End:
 2,355,100 bp from pter
Size:
 26,484 bases      Orientation:
 plus strand

Proteins
for SPPL2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPP2B_HUMAN, Q8TCT7 (See protein sequence)
Recommended Name: Signal peptide peptidase-like 2B precursor  
Size: 592 amino acids; 64644 Da
Subunit: Monomer. Homodimer. Interacts with ITM2B and TNF
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein. Note=targeted through the entire secretory
pathway to endosomes/lysosomes
Sequence caution: Sequence=AAC05601.1; Type=Erroneous gene model prediction; Sequence=AAG45441.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened; Sequence=BAA96056.1; Type=Erroneous initiation; Note=Translation
N-terminally shortened;
Secondary accessions: D6W609 O60365 Q567S3 Q8IUH9 Q9BUY6 Q9H3M4 Q9NPN2 Q9P1Z6
Alternative splicing: 4 isoforms:  Q8TCT7-1   Q8TCT7-2   Q8TCT7-3   Q8TCT7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPPL2B: NX_Q8TCT7

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TCT7

    • SPPL2B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001070706.1  NP_694533.1  

    Human Recombinant Protein Products: 
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    Uscn Proteins for SPPL2B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA15998642
    GO:0005886plasma membrane IDA--
    GO:0010008endosome membrane IDA15998642
    GO:0030660Golgi-associated vesicle membrane IDA17965014
    GO:0071458integral to cytosolic side of endoplasmic reticulum membrane IDA15385547


    SPPL2B for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for SPPL2B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPPL2B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006639 Peptidase_A22
     IPR003137 Protease-assoc_domain
     IPR007369 Peptidase_A22B_SPP

    Graphical View of Domain Structure for InterPro Entry Q8TCT7

    ProtoNet protein and cluster: Q8TCT7

    UniProtKB/Swiss-Prot: SPP2B_HUMAN, Q8TCT7
    Domain: The PAL motif is required for normal active site conformation (By similarity). The catalytic domains embedded
    in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted
    to cleave type II-oriented substrate peptides like the prototypic protease SPP
    Similarity: Belongs to the peptidase A22B family
    Similarity: Contains 1 PA (protease associated) domain


    Function
    for SPPL2B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPP2B_HUMAN, Q8TCT7
    Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
    hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the
    anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling
    to the nucleus. May play a role in the regulation of innate and adaptive immunity

    Enzyme Number (IUBMB): EC 3.4.23.-1

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17965014
    GO:0042500NOT aspartic endopeptidase activity, intramembrane cleaving IMP16873890
    GO:0042803protein homodimerization activity IDA15385547


    SPPL2B for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SPPL2B:
     Decreased viability with pacli  Synthetic lethal with Ras 


    Pathways & Interactions
    for SPPL2B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPPL2B

    1 Interacting protein for SPPL2B (Q8TCT73) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PACSIN1Q9BY113I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006509membrane protein ectodomain proteolysis IDA16829951
    GO:0031293membrane protein intracellular domain proteolysis IMP--
    GO:0050776regulation of immune response IMP16829952


    SPPL2B for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPPL2B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPPL2B
    Search CenterWatch for drugs/clinical trials and news about SPPL2B / SPP2B 

    Transcripts
    for SPPL2B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPPL2B gene (2 alternative transcripts): 
    NM_001077238.1  NM_152988.2  

    Unigene Cluster for SPPL2B:

    Signal peptide peptidase like 2B
    Hs.744026  [show with all ESTs]
    Unigene Representative Sequence: NM_001077238
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585725 ENST00000592845 ENST00000586332 ENST00000590982 ENST00000586377
    ENST00000593198 ENST00000592738 ENST00000586111 ENST00000587851 ENST00000593243
    ENST00000591959 ENST00000590295 ENST00000590902 ENST00000589515 ENST00000452401(uc010dsw.1 uc010dsy.1 uc010dsz.1 uc002lvr.3 uc002lvs.3 uc010dta.1 uc002lvu.3)
    ENST00000382189

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate SPPL2B:
    hsa-miR-135b hsa-miR-2909 hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-135a hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmid: SPPL2B 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SPPL2B
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB040965.1 AJ345027.1 AJ420897.1 AK226130.1 AK308973.1 AK309122.1 AY169315.1 BC001788.1 
    BC028391.2 BC093046.1 

    19 DOTS entries:

    DT.100789037  DT.313472  DT.100789039  DT.100027540  DT.100789045  DT.430864  DT.97778080  DT.121414634 
    DT.100027537  DT.100789044  DT.100773424  DT.100027541  DT.92437934  DT.100763805  DT.121414494  DT.92437940 
    DT.99966551  DT.95259900  DT.95307752 

    24/252 AceView cDNA sequences (see all 252):

    BQ681216 BE048448 AW955165 BM791099 BQ677981 AL040279 NM_020172 CA419230 
    BU782927 BE253442 AJ420897 CR602216 AI680443 BF001571 BG394865 BE552158 
    BG474186 BE254254 AA453953 BI029051 BU782805 F10738 CR624124 BU838197 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for SPPL2B (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                    -     -                 -           -                                                     -     -                                       
    SP2:                    -     -                 -           -                                                     -     -                                       
    SP3:                    -     -                 -           -                                                                                                   
    SP4:                    -     -                 -           -     -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 17b · 17c ^ 18a · 18b
    SP1:        -               
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for SPPL2B

    Expression
    for SPPL2B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPPL2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGCACACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SPPL2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPPL2B

    SOURCE GeneReport for Unigene cluster: Hs.744026

    UniProtKB/Swiss-Prot: SPP2B_HUMAN, Q8TCT7
    Tissue specificity: Expressed predominantly in adrenal cortex and mammary gland

        SABiosciences Custom PCR Arrays for SPPL2B
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    In Situ
    Assay Products:     
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    Orthologs
    for SPPL2B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPPL2B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Sppl2b1 , 5 RIKEN cDNA 3110056O03 gene5
    signal peptide peptidase like 2B1    		 80.45(n)1
    80.28(a)1    		   10 (39.72 cM)5
    732181  NM_175195.31  NP_780404.21 
     808552755 
    chicken
    (Gallus gallus)    		 Aves SPPL2B1 signal peptide peptidase like 2B 70.55(n)
    78.32(a)    		   420056  NM_001030933.1  NP_001026104.1 
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC691132 hypothetical protein MGC69113 75.31(n)    BC056100.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC044512.12   -- 76.26(n)    BC044512.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SPPL31 signal peptide peptidase-like 3 45.13(n)
    37.17(a)    		   818909  NM_180052.3  NP_850383.2 
    rice
    (Oryza sativa)    		 Liliopsida Os01g09147001 hypothetical protein 49.25(n)
    37.69(a)    		   4324348  NM_001051717.1  NP_001045182.1 


    ENSEMBL Gene Tree for SPPL2B (if available)
    TreeFam Gene Tree for SPPL2B (if available) 

    Paralogs
    for SPPL2B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SPPL2B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/722 NCBI SNPs in SPPL2B are shown (see all 722)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs562028001,2
    		C--2118169(+) ACTCAC/TGCGCT 1 -- int10--------
    rs800674831,2
    		F,--2330839(+) TTATCC/TGGAGG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs739169251,2
    		C,--2330840(+) TATCCG/TGAGGG 2 -- int12Minor allele frequency- T:0.27WA 120
    rs1854509841,2
    		--2330851(+) TGGGGA/CGTCAA 2 -- int10--------
    rs37950401,2
    		C,F,H,--2330933(+) TGAGAC/AGCCTG 2 -- int18Minor allele frequency- A:0.01EA NS 2356
    rs735205481,2
    		C,F,--2330962(+) GCTTCG/ACGGCA 2 -- int17Minor allele frequency- A:0.33WA NA CSA 248
    rs735205511,2
    		C,--2331057(+) TTGCTA/GCCATT 2 -- int13Minor allele frequency- G:0.34WA 122
    rs1895239051,2
    		--2331104(+) AGACAC/GCTCCC 2 -- int10--------
    rs1808081421,2
    		--2331130(+) GAGCCC/GGCTCC 2 -- int10--------
    rs118823301,2
    		C,F,A,H,--2331181(+) CGGCCC/TGGCTC 2 -- int115Minor allele frequency- T:0.09NS EA NA 1962

    HapMap Linkage Disequilibrium report for SPPL2B (2328617 - 2355100 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for SPPL2B
         2 CNVs: 5068 73281
         3 Indels: 102766 26222 45743

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    Disorders / Diseases
    for SPPL2B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPPL2B for disorders           About GeneDecksing

    OMIM gene information: 608239    OMIM disorders: --

    3 diseases for SPPL2B:    About MalaCards
    alzheimer's disease    malaria    dementia


    Export disorders for SPPL2B gene to outside databases

    Publications
    for SPPL2B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPPL2B gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with SPPL2B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. (PubMed id 16873890)1, 2, 9 Nyborg A.C....Golde T.E. (2006)
    3. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. (PubMed id 17965014)1, 2, 9 Martin L....Haass C. (2008)
    4. The alpha-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). (PubMed id 22194595)1, 2 Fluhrer R.... Haass C. (2012)
    5. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. (PubMed id 19114711)1, 2 Martin L....Haass C. (2009)
    6. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. (PubMed id 16829951)1, 2 Fluhrer R....Haass C. (2006)
    7. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. (PubMed id 16829952)1, 2 Friedmann E....Martoglio B. (2006)
    8. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. (PubMed id 15998642)1, 2 Krawitz P....Haass C. (2005)
    9. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. (PubMed id 15385547)1, 2 Friedmann E.... Martoglio B. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for SPPL2B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SPPL2B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56928 HGNC: 30627 AceView: SPPL2B Ensembl:ENSG00000005206 euGenes: HUgn56928
    ECgene: SPPL2B H-InvDB: SPPL2B

    Other Databases showing SPPL2B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1532

    Specialized Databases showing SPPL2B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for SPPL2B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPPL2B gene:
    Search GeneIP for patents involving SPPL2B

    GeneCards and IP:
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