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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPPL2A Gene

protein-coding GIFtS: 54
GCID: GC15M050999

Signal Peptide Peptidase Like 2A

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Signal Peptide Peptidase Like 2A¹ ²		SPP-Like 2A² ³
Intramembrane Protease 3¹ ² ³		Intramembrane Cleaving Protease²
Presenilin-Like Protein 2¹ ² ³		Signal Peptide Peptidase-Like 2A²
IMP3² ³ ⁵		EC 3.4.23.-³
IMP-3² ³		SPPL2a³
PSL2² ³

External Ids:	HGNC: 30227¹	Entrez Gene: 84888²	Ensembl: ENSG00000138600⁷	OMIM: 608238⁵	UniProtKB: Q8TCT8³

Export aliases for SPPL2A gene to outside databases

Previous GC identifers: GC15M046557 GC15M044045 GC15M048578 GC15M048715 GC15M048787 GC15M027830

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPPL2A Gene:

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two

conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal

peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and

localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on

chromosome 15. (provided by RefSeq, Feb 2012)

GeneCards Summary for SPPL2A Gene:

SPPL2A (signal peptide peptidase like 2A) is a protein-coding gene. Diseases associated with SPPL2A include psoriatic arthritis, and malaria. GO annotations related to this gene include aspartic-type endopeptidase activity and protein homodimerization activity. An important paralog of this gene is HM13.

UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8

Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the

hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane

cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain

(ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG,

which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of

innate and adaptive immunity

Gene Wiki entry for SPPL2A Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NT_010194.17 NC_018926.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPPL2A gene promoter:
GR Elk-1 E47 Evi-1 MEF-2A POU2F1 POU2F1a GR-alpha aMEF-2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPPL2A promoter sequence

Search SABiosciences Chromatin IP Primers for SPPL2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPPL2A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.2

SPPL2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPPL2A gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M050999: view genomic region (about GC identifiers)

Start:	50,999,506 bp from pter	End:	51,058,005 bp from pter
Size:	58,500 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8 (See protein sequence)

Recommended Name: Signal peptide peptidase-like 2A precursor

Size: 520 amino acids; 58143 Da

Subunit: Interacts with ITM2B

Subcellular location: Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane;

Multi-pass membrane protein (By similarity). Cell membrane. Note=Colocalizes with palmitoylated and myristoylated

proteins at the plasma membrane

Sequence caution: Sequence=BAB55117.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=CAD13133.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: B2RDS0 Q8TAW1 Q96SZ8

Explore the universe of human proteins at neXtProt for SPPL2A: NX_Q8TCT8

Explore proteomics data for SPPL2A at MOPED

Post-translational modifications:

UniProtKB: Glycosylated

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q8TCT8

SPPL2A Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_116191.2

ENSEMBL proteins:

ENSP00000261854 ENSP00000453927 ENSP00000453932

Human Recombinant Protein Products for SPPL2A:

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Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005765	lysosomal membrane	IDA	17897319
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	--	--
GO:0030660	Golgi-associated vesicle membrane	IDA	17965014
GO:0031902	late endosome membrane	IEA	--

SPPL2A for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro protein domains:

IPR006639 Peptidase_A22

IPR003137 Protease-assoc_domain

IPR007369 Peptidase_A22B_SPP

Graphical View of Domain Structure for InterPro Entry Q8TCT8

ProtoNet protein and cluster: Q8TCT8

1 Blocks protein domain: IPB003137 Protease-associated PA

UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8

Domain: The PAL motif is required for normal active site conformation (By similarity). The catalytic domains

embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it

is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP

Similarity: Belongs to the peptidase A22B family

Similarity: Contains 1 PA (protease associated) domain

SPPL2A for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: SPP2A_HUMAN, Q8TCT8

Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the

hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane

cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain

(ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG,

which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of

innate and adaptive immunity

Enzyme Number (IUBMB): EC 3.4.23.-¹

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004190	aspartic-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	17965014
GO:0042803	protein homodimerization activity	IDA	15385547

SPPL2A for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SPPL2A:

Increased G1 DNA content

Increased HPV18 LCR reporter a

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Sppl2a):

cellular

hematopoietic system

immune system

SPPL2A for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for SPPL2A: Sppl2a^tm1Basc Sppl2a^tm1Dgen

inGenious Targeting Laboratory - Custom generated mouse model solutions for SPPL2A

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPPL2A

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPPL2A

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPPL2A

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPPL2A
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPPL2A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPPL2A

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for SPPL2A (Q8TCT8^{2, 3} ENSP00000261854⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SGTA	O43765²^,³, ENSP00000221566⁴	MINT-67903 I2D: score=5 STRING: ENSP00000221566
LAMP2	P13473³	I2D: score=1
TFRC	P02786²	MINT-8412736
SUGT1	ENSP00000367208⁴	STRING: ENSP00000367208
NFKB1	ENSP00000226574⁴	STRING: ENSP00000226574

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006509	membrane protein ectodomain proteolysis	IDA	16829951
GO:0031293	membrane protein intracellular domain proteolysis	IMP	16829952
GO:0050776	regulation of immune response	IMP	16829952

SPPL2A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPPL2A (SPP2A)

Search CenterWatch for drugs/clinical trials and news about SPPL2A / SPP2A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPPL2A gene:

NM_032802.3

Unigene Cluster for SPPL2A:

Signal peptide peptidase like 2A

Hs.401537 [show with all ESTs]

Unigene Representative Sequence: BC025740

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000261854(uc001zyv.3) ENST00000558934 ENST00000559293 ENST00000558146

ENST00000559527 ENST00000558414 ENST00000560288

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		hsa-miR-124 hsa-miR-506
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Additional mRNA sequence:

AJ345028.1 AJ420896.1 AK027446.1 AK075454.1 AK315651.1 AY169314.1 BC025740.1

11 DOTS entries:

DT.113009 DT.100784170 DT.100784166 DT.95374734 DT.65285814 DT.100784167 DT.91742488 DT.91742490

DT.97841869 DT.99947206 DT.95374728

24/73 AceView cDNA sequences (see all 73):

BQ016314 NM_032802 BP338432 AJ420896 BI492849 BU633276 BI770056 BQ049401

AA988423 AW304186 BP343058 BC025740 CR626792 AY169314 AJ345028 BM919716

AK027446 BX476355 BI833590 BG541552 AI823363 BE465131 BU676225 BI818316

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for SPPL2A About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	·	13c	^	14	^	15a	·	15b	^	16	^	17
SP1:									-														-		-						-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for SPPL2A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPPL2A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATACTTACAT

About this image

See SPPL2A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPPL2A

SOURCE GeneReport for Unigene cluster: Hs.401537

UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8

Tissue specificity: Ubiquitous

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPPL2A gene from 7/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Sppl2a^{1 , 5}	RIKEN cDNA 2010106G01 gene⁵ signal peptide peptidase like 2A¹	83.82(n)¹ 80.54(a)¹		2 (61.76 cM)⁵ 66552¹ NM_023220.2¹ NP_075709.2¹ 126890391⁵
chicken (Gallus gallus)	Aves	SPPL2A¹	signal peptide peptidase like 2A	74.54(n) 72.07(a)		415450 NM_001012769.1 NP_001012787.1
lizard (Anolis carolinensis)	Reptilia	SPPL2A⁶	signal peptide peptidase like 2A	53(a)	1 ↔ 1	GL343747.1(82531-196635)
zebrafish (Danio rerio)	Actinopterygii	zgc:123258¹	zgc:123258	55.51(n) 50.62(a)		641502 NM_001037439.1 NP_001032516.1
worm (Caenorhabditis elegans)	Secernentea	C36B1.12³	--	28(a)		I(8760309-8763421) --
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	YKL100C⁶	Putative protein of unknown function with similari...	13(a)	1 → many	XI(253697-255460)
rice (Oryza sativa)	Liliopsida	Os11g0433200¹	hypothetical protein	48.47(n) 35.01(a)		4350402 NM_001074329.1 NP_001067797.1

ENSEMBL Gene Tree for SPPL2A (if available)
TreeFam Gene Tree for SPPL2A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPPL2A gene

HM13² SPPL2C² SPPL3²

2 SIMAP similar genes for SPPL2A using alignment to 3 protein entries: SPP2A_HUMAN (see all proteins):

SPPL2B SPPL2C

SPPL2A for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for SPPL2A
PGOHUM00000246782

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72740493^1,2	C,F	--	50999258(+)	`TCACCG/TTTGAA`	1	--	ds500¹		3		WA NA EA	358
rs12911654^1,2	C,F,A,H	--	50999299(+)	`TTCTAC/TAGAGC`	1	--	ds500¹		12		NS EA NA CSA WA	776
rs12912841^1,2		--	50999332(+)	`TTTTTT/GTGGGA`	1	--	ds500¹		2		NA	122
rs12912843^1,2	C	--	50999333(+)	`TTTTTG/TGGGAT`	1	--	ds500¹		1		NA	2
rs78789557^1,2	C	--	50999391(+)	`GCTCAC/GTGCAA`	1	--	ds500¹		0	--	--	--	--
rs28373855^1,2		--	50999488(+)	`TTTTTG/TGTATT`	1	--	ds500¹		0	--	--	--	--
rs150435817^1,2	C	--	50999516(+)	`TCACCA/GTGTTA`	1	--	ds500¹		0	--	--	--	--
rs183865904^1,2		--	50999536(+)	`GTCTCA/GATCTC`	1	--	ds500¹		0	--	--	--	--
rs188643878^1,2	C	--	50999561(+)	`CGCCCA/GCCTTG`	1	--	ds500¹		0	--	--	--	--
rs138117429^1,2		--	50999582(+)	`GTGTTC/GGGATT`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SPPL2A (50999506 - 51058005 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for SPPL2A: About this table

Variant ID	Type	Subtype	PubMed ID
esv2609237	CNV	Deletion	19546169
esv2659888	CNV	Deletion	23128226
nsv457137	CNV	Loss	19166990
nsv904213	CNV	Loss	21882294
nsv904212	CNV	Gain	21882294
dgv317n27	CNV	Gain	19166990
nsv471242	CNV	Gain	18288195

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608238 OMIM disorders: --

5 diseases for SPPL2A: About MalaCards

psoriatic arthritis malaria alzheimer's disease psoriasis

arthritis

SPPL2A for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

1 Novoseek inferred disease relationship for SPPL2A gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	48.8	1	15549135 (1)

Export disorders for SPPL2A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SPPL2A gene, integrated from 9 sources (see all 42):
(articles sorted by number of sources associating them with SPPL2A)

Utopia: connect your pdf to the dynamic
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Novel class of polytopic proteins with domains associated with putative protease activity. (PubMed id 12139484)^{1, 2, 3} Grigorenko A.P.... Rogaev E.I. (2002)
Identification of signal peptide peptidase, a presenilin-type aspartic protease. (PubMed id 12077416)^{1, 2, 3} Weihofen A.... Martoglio B. (2002)
Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. (PubMed id 15385547)^{1, 2, 9} Friedmann E.... Martoglio B. (2004)
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. (PubMed id 17965014)^{1, 2, 9} Martin L....Haass C. (2008)
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. (PubMed id 17557115)^{1, 2, 9} Kirkin V....Zornig M. (2007)
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. (PubMed id 16829951)^{1, 2} Fluhrer R....Haass C. (2006)
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. (PubMed id 16829952)^{1, 2} Friedmann E....Martoglio B. (2006)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84888	HGNC: 30227	AceView: SPPL2A	Ensembl:ENSG00000138600	euGenes: HUgn84888
ECgene: SPPL2A	H-InvDB: SPPL2A

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for SPPL2A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPPL2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for SPPL2A gene:
Search GeneIP for patents involving SPPL2A

GeneCards and IP:
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