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SPPL2A Gene

protein-coding   GIFtS: 55
GCID: GC15M050999

Signal Peptide Peptidase Like 2A

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Signal Peptide Peptidase Like 2A1 2     SPP-Like 2A2 3
Intramembrane Protease 31 2 3     Intramembrane Cleaving Protease2
Presenilin-Like Protein 21 2 3     Signal Peptide Peptidase-Like 2A2
IMP32 3 5     EC 3.4.23.-3
IMP-32 3     SPPL2a3
PSL22 3     

External Ids:    HGNC: 302271   Entrez Gene: 848882   Ensembl: ENSG000001386007   OMIM: 6082385   UniProtKB: Q8TCT83   

Export aliases for SPPL2A gene to outside databases

Previous GC identifers: GC15M046557 GC15M044045 GC15M048578 GC15M048715 GC15M048787 GC15M027830


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPPL2A Gene:
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two
conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal
peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and
localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on
chromosome 15. (provided by RefSeq, Feb 2012)

GeneCards Summary for SPPL2A Gene:
SPPL2A (signal peptide peptidase like 2A) is a protein-coding gene. Diseases associated with SPPL2A include psoriatic arthritis, and malaria. GO annotations related to this gene include aspartic-type endopeptidase activity and protein homodimerization activity. An important paralog of this gene is HM13.

UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8
Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane
cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain
(ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG,
which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of
innate and adaptive immunity

Gene Wiki entry for SPPL2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPPL2A gene promoter:
         GR   Elk-1   E47   Evi-1   MEF-2A   POU2F1   POU2F1a   GR-alpha   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPPL2A promoter sequence
   Search Chromatin IP Primers for SPPL2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPPL2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

SPPL2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPPL2A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050999:  view genomic region     (about GC identifiers)

Start:
50,999,506 bp from pter      End:
51,058,005 bp from pter
Size:
58,500 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8 (See protein sequence)
Recommended Name: Signal peptide peptidase-like 2A precursor  
Size: 520 amino acids; 58143 Da
Subunit: Interacts with ITM2B
Sequence caution: Sequence=BAB55117.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD13133.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RDS0 Q8TAW1 Q96SZ8

Explore the universe of human proteins at neXtProt for SPPL2A: NX_Q8TCT8

Explore proteomics data for SPPL2A at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn58, Asn66, Asn74, Asn116, Asn126, Asn149, Asn155
  • Modification sites at PhosphoSitePlus

  • See SPPL2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116191.2  
    ENSEMBL proteins: 
     ENSP00000261854   ENSP00000453927   ENSP00000453932  

    SPPL2A Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006639 Preselin/SPP
     IPR003137 Protease-assoc_domain
     IPR007369 Peptidase_A22B_SPP

    Graphical View of Domain Structure for InterPro Entry Q8TCT8

    ProtoNet protein and cluster: Q8TCT8

    1 Blocks protein domain: IPB003137 Protease-associated PA

    UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8
    Domain: The PAL motif is required for normal active site conformation (By similarity). The catalytic domains
    embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it
    is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP
    Similarity: Belongs to the peptidase A22B family
    Similarity: Contains 1 PA (protease associated) domain


    SPPL2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPP2A_HUMAN, Q8TCT8
    Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
    hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane
    cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain
    (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG,
    which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of
    innate and adaptive immunity

         Enzyme Number (IUBMB): EC 3.4.23.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity IEA--
    GO:0005515protein binding IPI17965014
    GO:0042803protein homodimerization activity IDA15385547
         
    SPPL2A for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SPPL2A:
     Increased G1 DNA content  Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Sppl2a):
     cellular  hematopoietic system  immune system 

    SPPL2A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SPPL2A: Sppl2atm1Basc Sppl2atm1Dgen

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPPL2A
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    miRNA
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    miRTarBase miRNAs that target SPPL2A:
    hsa-mir-26b-5p (MIRT028891), hsa-mir-34a-5p (MIRT025305)

    Block miRNA regulation of human, mouse, rat SPPL2A using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SPPL2A:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSPPL2A 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPP2A_HUMAN, Q8TCT8: Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane;
    Multi-pass membrane protein (By similarity). Cell membrane. Note=Colocalizes with palmitoylated and myristoylated
    proteins at the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    endosome5
    golgi apparatus5
    lysosome5
    plasma membrane5
    vacuole5
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane ----
    GO:0030660Golgi-associated vesicle membrane IDA17965014
    GO:0031902late endosome membrane IEA--

    SPPL2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPPL2A
    Interactions:

        Search GeneGlobe Interaction Network for SPPL2A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for SPPL2A (Q8TCT82, 3 ENSP000002618544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGTAO437652, 3, ENSP000002215664MINT-67903 I2D: score=5 STRING: ENSP00000221566
    LAMP2P134733, ENSP000004084114I2D: score=1 STRING: ENSP00000408411
    TFRCP027862MINT-8412736
    SUGT1ENSP000003672084STRING: ENSP00000367208
    NFKB1ENSP000002265744STRING: ENSP00000226574
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006509membrane protein ectodomain proteolysis IDA16829951
    GO:0031293membrane protein intracellular domain proteolysis IMP16829952
    GO:0050776regulation of immune response IMP16829952

    SPPL2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPPL2A (SPP2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPPL2A gene: 
    NM_032802.3  

    Unigene Cluster for SPPL2A:

    Signal peptide peptidase like 2A
    Hs.401537  [show with all ESTs]
    Unigene Representative Sequence: BC025740
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261854(uc001zyv.3) ENST00000558934 ENST00000559293 ENST00000558146
    ENST00000559527 ENST00000558414 ENST00000560288

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate SPPL2A:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidSPPL2A 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SPPL2A
      QuantiFast Probe-based Assays in human, mouse, rat SPPL2A

    Additional mRNA sequence: 

    AJ345028.1 AJ420896.1 AK027446.1 AK075454.1 AK315651.1 AY169314.1 BC025740.1 

    11 DOTS entries:

    DT.113009  DT.100784170  DT.100784166  DT.95374734  DT.65285814  DT.100784167  DT.91742488  DT.91742490 
    DT.97841869  DT.99947206  DT.95374728 

    Selected AceView cDNA sequences (see all 73):

    BC025740 BI770056 BP338432 BI492849 NM_032802 AW304186 AA988423 CR626792 
    AJ420896 BU633276 AY169314 BQ016314 BP343058 AJ345028 BQ049401 BE465131 
    BU076239 BI764078 BU676225 AK027446 BI834817 AI823363 BG541552 CA841385 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPPL2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                          -                                         -     -                 -                                 
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for SPPL2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPPL2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATACTTACAT
    SPPL2A Expression
    About this image

    SPPL2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPPL2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.401537

    UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPPL2A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Sppl2a1 , 5 RIKEN cDNA 2010106G01 gene5
    signal peptide peptidase like 2A1
    83.75(n)1
    80.54(a)1
      2 (61.76 cM)5
    665521  NM_023220.21  NP_075709.21 
     1268903915 
    chicken
    (Gallus gallus)
    Aves SPPL2A1 signal peptide peptidase like 2A 74.37(n)
    71.78(a)
      415450  NM_001012769.1  NP_001012787.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPPL2A6
    signal peptide peptidase like 2A
    53(a)
    1 ↔ 1
    GL343747.1(82531-196635)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia sppl2a1 signal peptide peptidase like 2A 65.36(n)
    61.89(a)
      100135083  NM_001113822.1  NP_001107294.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1232581 zgc:123258 55.67(n)
    51.06(a)
      641502  NM_001037439.1  NP_001032516.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C36B1.123
    imp-11
    imp-11 28(a)3
    48.54(n)1
    33.63(a)1
      I(8760309-8763421)3
    1726841  NM_001025854.31  NP_001021025.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative protein of unknown function with similari...
    16(a)
    1 → many
    XI(253697-255460) YKL100C
    rice
    (Oryza sativa)
    Liliopsida Os11g04332001 Os11g0433200 48.02(n)
    35.12(a)
      4350402  NM_001074329.1  NP_001067797.1 


    ENSEMBL Gene Tree for SPPL2A (if available)
    TreeFam Gene Tree for SPPL2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPPL2A gene
    HM132  SPPL2C2  SPPL32  
    2 SIMAP similar genes for SPPL2A using alignment to 3 protein entries:     SPP2A_HUMAN (see all proteins):
    SPPL2B    SPPL2C

    SPPL2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPPL2A
    PGOHUM00000246782


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPPL2A (see all 1269)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs727404931,2
    C,F--50999258(+) TCACCG/TTTGAA 1 -- ds50013Minor allele frequency- T:0.20WA NA EA 358
    rs129116541,2
    C,F,A,H--50999299(+) TTCTAC/TAGAGC 1 -- ds500112Minor allele frequency- T:0.10NS EA NA CSA WA 776
    rs129128411,2
    --50999332(+) TTTTTT/GTGGGA 1 -- ds50012Minor allele frequency- G:0.13NA 122
    rs129128431,2
    C--50999333(+) TTTTTG/TGGGAT 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs787895571,2
    C--50999391(+) GCTCAC/GTGCAA 1 -- ds50010--------
    rs283738551,2
    --50999488(+) TTTTTG/TGTATT 1 -- ds50010--------
    rs1504358171,2
    C--50999516(+) TCACCA/GTGTTA 1 -- ds50010--------
    rs1838659041,2
    --50999536(+) GTCTCA/GATCTC 1 -- ds50010--------
    rs1886438781,2
    C--50999561(+) CGCCCA/GCCTTG 1 -- ds50010--------
    rs1381174291,2
    --50999582(+) GTGTTC/GGGATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SPPL2A (50999506 - 51058005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for SPPL2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2609237CNV Deletion19546169
    esv2659888CNV Deletion23128226
    nsv457137CNV Loss19166990
    nsv904213CNV Loss21882294
    nsv904212CNV Gain21882294
    dgv317n27CNV Gain19166990
    nsv471242CNV Gain18288195

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608238    OMIM disorders: --

    5 diseases for SPPL2A:    
    About MalaCards
    psoriatic arthritis    malaria    alzheimer's disease    psoriasis
    arthritis


    SPPL2A for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for SPPL2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 48.8 1 15549135 (1)


    Export disorders for SPPL2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPPL2A gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with SPPL2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel class of polytopic proteins with domains associated with putative protease activity. (PubMed id 12139484)1, 2, 3 Grigorenko A.P.... Rogaev E.I. (Biokhimiia 2002)
    2. Identification of signal peptide peptidase, a presenilin-type aspartic protease. (PubMed id 12077416)1, 2, 3 Weihofen A.... Martoglio B. (Science 2002)
    3. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. (PubMed id 15385547)1, 2, 9 Friedmann E.... Martoglio B. (J. Biol. Chem. 2004)
    4. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. (PubMed id 17965014)1, 2, 9 Martin L.... Haass C. (J. Biol. Chem. 2008)
    5. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. (PubMed id 17557115)1, 2, 9 Kirkin V....Zornig M. (Cell Death Differ. 2007)
    6. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. (PubMed id 16829951)1, 2 Fluhrer R....Haass C. (Nat. Cell Biol. 2006)
    7. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. (PubMed id 16829952)1, 2 Friedmann E.... Martoglio B. (Nat. Cell Biol. 2006)
    8. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 84888 HGNC: 30227 AceView: SPPL2A Ensembl:ENSG00000138600 euGenes: HUgn84888
    ECgene: SPPL2A H-InvDB: SPPL2A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SPPL2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SPPL2A gene:
    Search GeneIP for patents involving SPPL2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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