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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPPL2A Gene

protein-coding   GIFtS: 52
GCID: GC15M050999

signal peptide peptidase like 2A
 Explore 5 diseases affiliated with
SPPL2A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPPL2A    

Aliases
for SPPL2A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Signal Peptide Peptidase Like 2A1 2     SPP-Like 2A2 3
IMP31 2 3 5     Intramembrane Cleaving Protease2
PSL21 2 3     Signal Peptide Peptidase-Like 2A2
Intramembrane Protease 32 3     EC 3.4.23.-3
Presenilin-Like Protein 22 3     SPPL2a3
IMP-32 3     

External Ids:    HGNC: 302271   Entrez Gene: 848882   Ensembl: ENSG000001386007   OMIM: 6082385   UniProtKB: Q8TCT83   

Export aliases for SPPL2A gene to outside databases

Previous GC identifers: GC15M046557 GC15M044045 GC15M048578 GC15M048715 GC15M048787 GC15M027830


Summaries
for SPPL2A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPPL2A:
This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two
conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide
peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to
late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15. (provided
by RefSeq, Feb 2012)

UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8
Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage
of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for
signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes
the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive
immunity

Gene Wiki entry for SPPL2A


Genomic Views
for SPPL2A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPPL2A gene promoter:
         GR   Elk-1   E47   Evi-1   MEF-2A   POU2F1   POU2F1a   GR-alpha   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPPL2A promoter sequence
   Search SABiosciences Chromatin IP Primers for SPPL2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPPL2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.2   Ensembl cytogenetic band:  15q21.2   HGNC cytogenetic band: 15q21.2

SPPL2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPPL2A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M050999:  view genomic region     (about GC identifiers)

Start:
 50,999,506 bp from pter      End:
 51,058,005 bp from pter
Size:
 58,500 bases      Orientation:
 minus strand

Proteins
for SPPL2A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8 (See protein sequence)
Recommended Name: Signal peptide peptidase-like 2A precursor  
Size: 520 amino acids; 58143 Da
Subunit: Interacts with ITM2B
Subcellular location: Late endosome membrane; Multi-pass membrane protein (By similarity). Lysosome membrane;
Multi-pass membrane protein (By similarity). Cell membrane. Note=Colocalizes with palmitoylated and myristoylated
proteins at the plasma membrane
Sequence caution: Sequence=BAB55117.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD13133.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RDS0 Q8TAW1 Q96SZ8

Explore the universe of human proteins at neXtProt for SPPL2A: NX_Q8TCT8

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TCT8

    • SPPL2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116191.2  
    ENSEMBL proteins: 
     ENSP00000261854   ENSP00000453927   ENSP00000453932  

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    Uscn Proteins for SPPL2A

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IEA--
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane ----
    GO:0030660Golgi-associated vesicle membrane IDA17965014
    GO:0031902late endosome membrane IEA--


    SPPL2A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SPPL2A

    Protein Domains /
    Families
    for SPPL2A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPPL2A for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006639 Peptidase_A22
     IPR003137 Protease-assoc_domain
     IPR007369 Peptidase_A22B_SPP

    Graphical View of Domain Structure for InterPro Entry Q8TCT8

    ProtoNet protein and cluster: Q8TCT8

    1 Blocks protein family: IPB003137 Protease-associated PA

    UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8
    Domain: The PAL motif is required for normal active site conformation (By similarity). The catalytic domains embedded
    in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted
    to cleave type II-oriented substrate peptides like the prototypic protease SPP
    Similarity: Belongs to the peptidase A22B family
    Similarity: Contains 1 PA (protease associated) domain


    Function
    for SPPL2A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8
    Function: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the
    hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage
    of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for
    signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes
    the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and adaptive
    immunity

    Enzyme Number (IUBMB): EC 3.4.23.-1

    miRNA
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    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: SPPL2A 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SPPL2A
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for SPPL2A

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004190aspartic-type endopeptidase activity IEA--
    GO:0005515protein binding IPI17965014
    GO:0042803protein homodimerization activity IDA15385547


    SPPL2A for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SPPL2A:
     Increased G1 DNA content  Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for SPPL2A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPPL2A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for SPPL2A (Q8TCT82, 3 ENSP000002618544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SGTAO437652, 3, ENSP000002215664MINT-67903 I2D: score=5 STRING: ENSP00000221566
    LAMP2P134733I2D: score=1 
    TFRCP027862MINT-8412736
    SUGT1ENSP000003672084STRING: ENSP00000367208
    NFKB1ENSP000002265744STRING: ENSP00000226574
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006509membrane protein ectodomain proteolysis IDA16829951
    GO:0031293membrane protein intracellular domain proteolysis IMP16829952
    GO:0050776regulation of immune response IMP16829952


    SPPL2A for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPPL2A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPPL2A
    Search CenterWatch for drugs/clinical trials and news about SPPL2A / SPP2A 

    Transcripts
    for SPPL2A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPPL2A gene: 
    NM_032802.3  

    Unigene Cluster for SPPL2A:

    Signal peptide peptidase like 2A
    Hs.401537  [show with all ESTs]
    Unigene Representative Sequence: BC025740
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261854(uc001zyv.3) ENST00000558934 ENST00000559293 ENST00000558146
    ENST00000559527 ENST00000558414 ENST00000560288

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate SPPL2A:
    hsa-miR-124 hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: SPPL2A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPPL2A (see all 4)
    OriGene shRNA RFP: SPPL2A
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPPL2A
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPPL2A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPPL2A

    Additional cDNA sequence: 

    AJ345028.1 AJ420896.1 AK027446.1 AK075454.1 AK315651.1 AY169314.1 BC025740.1 

    11 DOTS entries:

    DT.113009  DT.100784170  DT.100784166  DT.95374734  DT.65285814  DT.100784167  DT.91742488  DT.91742490 
    DT.97841869  DT.99947206  DT.95374728 

    24/73 AceView cDNA sequences (see all 73):

    AY169314 AA988423 BC025740 BQ049401 CR626792 AW304186 BP343058 BU633276 
    BI770056 AJ420896 BI492849 BQ016314 BP338432 NM_032802 AJ345028 AK027446 
    BE465131 AF090911 BQ220105 BI495520 BM919716 CA841385 BU076490 BU676225 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPPL2A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                          -                                         -     -                 -                                 
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              


    ECgene alternative splicing isoforms for SPPL2A

    Expression
    for SPPL2A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPPL2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATACTTACAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See SPPL2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPPL2A

    SOURCE GeneReport for Unigene cluster: Hs.401537

    UniProtKB/Swiss-Prot: SPP2A_HUMAN, Q8TCT8
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:     
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    Orthologs
    for SPPL2A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPPL2A gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPPL2A1 signal peptide peptidase like 2A 74.54(n)
    72.07(a)    		   415450  NM_001012769.1  NP_001012787.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SPPL2A6
    		 --
    		 58(a)
    		 1 ↔ 1
    		 GL343747.1(173232-190820)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc:1232581 zgc:123258 55.51(n)
    50.62(a)    		   641502  NM_001037439.1  NP_001032516.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C36B1.123   -- 28(a)   I(8760309-8763421)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons SPPL36
    SPPL26
    (see all 4)    		 signal peptide peptidase-like 2
    (see all 4)    		 26(a)
    26(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 2(17910888-17914870)
    1(23618378-23622396)
    rice
    (Oryza sativa)    		 Liliopsida Os11g04332001 hypothetical protein 48.47(n)
    35.01(a)    		   4350402  NM_001074329.1  NP_001067797.1 


    ENSEMBL Gene Tree for SPPL2A (if available)
    TreeFam Gene Tree for SPPL2A (if available) 

    Paralogs
    for SPPL2A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPPL2A gene
    SPPL2C2  HM132  SPPL32  
    2 SIMAP similar genes for SPPL2A using alignment to 3 protein entries:     SPP2A_HUMAN (see all proteins):
    SPPL2B    SPPL2C

    SPPL2A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SPPL2A
    PGOHUM00000246782


    Genomic Variants
    for SPPL2A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1130 NCBI SNPs in SPPL2A are shown (see all 1130)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs727404931,2
    		C,F,--50999258(+) TCACCG/TTTGAA 1 -- ds50013Minor allele frequency- T:0.20WA NA EA 358
    rs129116541,2
    		C,F,A,H,--50999299(+) TTCTAC/TAGAGC 1 -- ds500112Minor allele frequency- T:0.10NS EA NA CSA WA 776
    rs129128411,2
    		--50999332(+) TTTTTT/GTGGGA 1 -- ds50012Minor allele frequency- G:0.13NA 122
    rs129128431,2
    		C,--50999333(+) TTTTTG/TGGGAT 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs787895571,2
    		C,--50999391(+) GCTCAC/GTGCAA 1 -- ds50010--------
    rs283738551,2
    		--50999488(+) TTTTTG/TGTATT 1 -- ds50010--------
    rs1504358171,2
    		--50999516(+) TCACCA/GTGTTA 1 -- ds50010--------
    rs1838659041,2
    		--50999536(+) GTCTCA/GATCTC 1 -- ds50010--------
    rs1886438781,2
    		--50999561(+) CGCCCA/GCCTTG 1 -- ds50010--------
    rs1381174291,2
    		--50999582(+) GTGTTC/GGGATT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SPPL2A (50999506 - 51058005 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SPPL2A
         3 CNVs: 102100 53349 29644

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    Disorders / Diseases
    for SPPL2A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPPL2A for disorders           About GeneDecksing

    OMIM gene information: 608238    OMIM disorders: --

    5 diseases for SPPL2A:    About MalaCards
    psoriatic arthritis    alzheimer's disease    arthritis    psoriasis
    malaria

    1 Novoseek disease relationship for SPPL2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 48.8 1 15549135 (1)


    Export disorders for SPPL2A gene to outside databases

    Publications
    for SPPL2A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPPL2A gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with SPPL2A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel class of polytopic proteins with domains associated with putative protease activity. (PubMed id 12139484)1, 2, 3 Grigorenko A.P.... Rogaev E.I. (2002)
    2. Identification of signal peptide peptidase, a presenilin-type aspartic protease. (PubMed id 12077416)1, 2, 3 Weihofen A.... Martoglio B. (2002)
    3. Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins. (PubMed id 15385547)1, 2, 9 Friedmann E.... Martoglio B. (2004)
    4. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. (PubMed id 17965014)1, 2, 9 Martin L....Haass C. (2008)
    5. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. (PubMed id 17557115)1, 2, 9 Kirkin V....Zornig M. (2007)
    6. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. (PubMed id 16829951)1, 2 Fluhrer R....Haass C. (2006)
    7. SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production. (PubMed id 16829952)1, 2 Friedmann E....Martoglio B. (2006)
    8. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for SPPL2A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    OMIM
    NCBI Bookshelf
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    Genome Databases showing SPPL2A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84888 HGNC: 30227 AceView: SPPL2A Ensembl:ENSG00000138600 euGenes: HUgn84888
    ECgene: SPPL2A H-InvDB: SPPL2A

    Other Databases showing SPPL2A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPPL2A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for SPPL2A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPPL2A gene:
    Search GeneIP for patents involving SPPL2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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