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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPP2 Gene

protein-coding   GIFtS: 47
GCID: GC02P234975

Secreted Phosphoprotein 2, 24kDa

(Previous names: secreted phosphoprotein 2, 24kD)
  Search for SPP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Secreted Phosphoprotein 2, 24kDa1 2     Secreted Phosphoprotein 242
SPP242 3     Spp-243
Secreted Phosphoprotein 2, 24kD1     Secreted Phosphoprotein 23
SPP-242     

External Ids:    HGNC: 112561   Entrez Gene: 66942   Ensembl: ENSG000000720807   OMIM: 6026375   UniProtKB: Q131033   

Export aliases for SPP2 gene to outside databases

Previous GC identifers: GC02P232967 GC02P233641 GC02P235246 GC02P234741 GC02P234624 GC02P226759


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPP2 Gene:
This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. (provided by RefSeq, Oct
2008)

GeneCards Summary for SPP2 Gene: 
SPP2 (secreted phosphoprotein 2, 24kDa) is a protein-coding gene. GO annotations related to this gene include endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103
Function: Could coordinate an aspect of bone turnover (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005120.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPP2 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   GCNF   E2F-2   E2F-1   E2F   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

SPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234975:  view genomic region     (about GC identifiers)

Start:
234,959,323 bp from pter      End:
234,985,778 bp from pter
Size:
26,456 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103 (See protein sequence)
Recommended Name: Secreted phosphoprotein 24 precursor  
Size: 211 amino acids; 24338 Da
Subcellular location: Secreted
Developmental stage: Found in fetal liver and kidney
Secondary accessions: A4QMV3 Q3B892 Q546M5

Explore the universe of human proteins at neXtProt for SPP2: NX_Q13103

Explore proteomics data for SPP2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13103

  • SPP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPP2 Protein Expression
    REFSEQ proteins: NP_008875.1  
    ENSEMBL proteins: 
     ENSP00000362466   ENSP00000168148   ENSP00000417036  

    Human Recombinant Protein Products for SPP2: 
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    Cloud-Clone Corp. Proteins for SPP2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0043234protein complex IEA--

    SPP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR010892 Spp-24

    Graphical View of Domain Structure for InterPro Entry Q13103

    ProtoNet protein and cluster: Q13103

    1 Blocks protein domain: IPB010892 Secreted phosphoprotein 24

    UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103
    Similarity: Belongs to the SPP2 family


    SPP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPP24_HUMAN, Q13103
    Function: Could coordinate an aspect of bone turnover (By similarity)

         Genatlas biochemistry entry for SPP2:
    secreted phosphoprotein2,24kDa,expressed in bone,bovine spp24 homolog

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS7814406
    GO:0004869cysteine-type endopeptidase inhibitor activity ----
         
    SPP2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPP2 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPP2

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS7814406
    GO:0006461protein complex assembly IEA--
    GO:0010951negative regulation of endopeptidase activity TAS7814406
    GO:0046849bone remodeling IEA--

    SPP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPP2 (SPP24)

    Search CenterWatch for drugs/clinical trials and news about SPP2 / SPP24

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPP2 gene: 
    NM_006944.2  

    Unigene Cluster for SPP2:

    Secreted phosphoprotein 2, 24kDa
    Hs.444488  [show with all ESTs]
    Unigene Representative Sequence: NM_006944
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373368(uc010fyl.1) ENST00000168148(uc002vvk.1) ENST00000425558
    ENST00000492481
    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPP2
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    Additional mRNA sequence: 

    AJ308099.1 BC069401.1 BC106705.1 BC112438.1 BC113972.1 U20530.1 

    4 DOTS entries:

    DT.453598  DT.92417474  DT.92417475  DT.91943145 

    24/31 AceView cDNA sequences (see all 31):

    BX405937 AV718912 AJ308099 BX097970 CR607621 AW340137 AW119013 AV645964 
    N74450 BC069401 NM_006944 N54053 CB163851 CB164241 AV656125 AI005085 
    R29227 U20530 BX496642 AI221684 AI032584 W03162 AA054823 BE971485 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPP2 expression in normal human tissues (normalized intensities)      SPP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACGGTGGT
    SPP2 Expression
    About this image


    SPP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Proximal Tubule Cells Proximal Tubule
             Proximal Tubule
             visceral organ/metanephros/renal cortex   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Liver (Hepatobiliary System)
             Liver Lobule
     
     Spleen (Hematopoietic System)

    See SPP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPP2

    SOURCE GeneReport for Unigene cluster: Hs.444488

    UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103
    Tissue specificity: Detected in liver and plasma

        SABiosciences Custom PCR Arrays for SPP2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPP2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spp21 , 5 secreted phosphoprotein 21, 5 75.71(n)1
    69.35(a)1
      1 (44.63 cM)5
    753961  NM_029269.21  NP_083545.11 
     884069615 
    chicken
    (Gallus gallus)
    Aves SPP26
    secreted phosphoprotein 24
    38(a)
    1 ↔ 1
    7(5546056-5553781)
    zebrafish
    (Danio rerio)
    Actinopterygii SPP26
    secreted phosphoprotein 2, 24kDa
    24(a)
    1 ↔ 1
    1(28688682-28692942)


    ENSEMBL Gene Tree for SPP2 (if available)
    TreeFam Gene Tree for SPP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/767 SNPs in SPP2 are shown (see all 767)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs32164941,2
    C--226761525(+) AAAAAA/CATCAC 1 -- int10--------
    rs599078851,2
    C--226767951(+) ATGTCTT/-GGGTG 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1436863881,2
    C--234330323(+) TTTGGC/TTTTTG 1 -- us2k10--------
    rs1471928561,2
    --234330353(+) TTTAGC/TCATGA 1 -- us2k10--------
    rs1405541761,2
    --234330374(+) CATGCC/TTATGT 1 -- us2k10--------
    rs1905620391,2
    C--234330434(+) TTTTAC/TGTTTA 1 -- us2k10--------
    rs1443980141,2
    C--234330435(+) TTTACA/GTTTAA 1 -- us2k10--------
    rs178647991,2
    C,H--234330500(+) TTTCAG/TCTTTC 1 -- us2k17Minor allele frequency- T:0.22NS EA CSA NA 540
    rs178657021,2
    C,F,H--234330571(+) TGAACC/AGACAC 1 -- us2k17Minor allele frequency- A:0.11NS EA CSA NA 540
    rs1116301451,2
    C--234330646(+) TTAGAA/GAAATG 1 -- us2k11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for SPP2 (234959323 - 234985778 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SPP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv10224CNV Loss18304495
    nsv834571CNV Gain17160897


    Human Gene Mutation Database (HGMD): SPP2
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SPP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPP2 for disorders           About MalaCards
    OMIM gene information: 602637    OMIM disorders: --


    SPP2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPP2
    Human Genome Epidemiology (HuGE) Navigator: SPP2 (1 document)

    Export disorders for SPP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPP2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SPP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. (PubMed id 15062857)1, 2, 9 Bennett C.S....Dalgleish R. (2004)
    2. Assignment of secreted phosphoprotein 24 (SPP2) to human chromosome band 2q37-->qter by in situ hybridization. (PubMed id 9533032)1, 3, 9 Swallow J.E....Dalgleish R. (1997)
    3. An integration of genome-wide association study and g ene expression profiling to prioritize the discovery of novel susceptibility Lo ci for osteoporosis-related traits. (PubMed id 20548944)1, 4 Hsu Y.H....Kiel D.P. (2010)
    4. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (2009)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Bone morphogenetic protein-2 activity is regulated by secreted phosphoprotein-24 kd, an extracellular pseudoreceptor, the gene for which maps to a region of the human genome important for bone quality. (PubMed id 19375587)1, 9 Brochmann E.J....Murray S.S. (2009)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6694 HGNC: 11256 AceView: SPP2 Ensembl:ENSG00000072080 euGenes: HUgn6694
    ECgene: SPP2 H-InvDB: SPP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPP2 gene:
    Search GeneIP for patents involving SPP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     OriGene Custom Antibody Services for SPP2   OriGene Custom Protein Services for SPP2  

     
     
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     Regulatory tfbs in SPP2 promoter
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     Search Tocris compounds for SPP2 (SPP24)
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     Proteins for SPP2
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     Search ThermoFisher Antibodies for SPP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPP2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPP2
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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