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Aliases for SPP2 Gene

Aliases for SPP2 Gene

  • Secreted Phosphoprotein 2 2 3 4 5
  • Secreted Phosphoprotein 2, 24kDa 2 3
  • Secreted Phosphoprotein 2, 24kD 2 3
  • SPP-24 3 4
  • SPP24 3 4

External Ids for SPP2 Gene

Previous GeneCards Identifiers for SPP2 Gene

  • GC02P232967
  • GC02P233641
  • GC02P234975
  • GC02P235246
  • GC02P234741
  • GC02P234624
  • GC02P226759

Summaries for SPP2 Gene

Entrez Gene Summary for SPP2 Gene

  • This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]

GeneCards Summary for SPP2 Gene

SPP2 (Secreted Phosphoprotein 2) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPP2 Gene

  • Could coordinate an aspect of bone turnover.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPP2 Gene

Genomics for SPP2 Gene

Regulatory Elements for SPP2 Gene

Enhancers for SPP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPP2 Gene

234,050,679 bp from pter
234,077,134 bp from pter
26,456 bases
Plus strand

Genomic View for SPP2 Gene

Genes around SPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPP2 Gene

Proteins for SPP2 Gene

  • Protein details for SPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secreted phosphoprotein 24
    Protein Accession:
    Secondary Accessions:
    • A4QMV3
    • Q3B892
    • Q546M5

    Protein attributes for SPP2 Gene

    211 amino acids
    Molecular mass:
    24338 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPP2 Gene

Proteomics data for SPP2 Gene at MOPED

Post-translational modifications for SPP2 Gene

  • Phosphorylation sites are present in the extracellular medium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPP2 Gene

Domains & Families for SPP2 Gene

Protein Domains for SPP2 Gene


Suggested Antigen Peptide Sequences for SPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SPP2 family.
  • Belongs to the SPP2 family.
genes like me logo Genes that share domains with SPP2: view

No data available for Gene Families for SPP2 Gene

Function for SPP2 Gene

Molecular function for SPP2 Gene

GENATLAS Biochemistry:
secreted phosphoprotein2,24kDa,expressed in bone,bovine spp24 homolog
UniProtKB/Swiss-Prot Function:
Could coordinate an aspect of bone turnover.
genes like me logo Genes that share phenotypes with SPP2: view

Animal Models for SPP2 Gene

MGI Knock Outs for SPP2:
  • Spp2 tm1(cre/ERT2)Amc

Animal Model Products

  • Taconic Biosciences Mouse Models for SPP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPP2 Gene

Localization for SPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPP2 Gene


Subcellular locations from

Jensen Localization Image for SPP2 Gene COMPARTMENTS Subcellular localization image for SPP2 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SPP2 Gene

Pathways & Interactions for SPP2 Gene

genes like me logo Genes that share pathways with SPP2: view

Interacting Proteins for SPP2 Gene

Gene Ontology (GO) - Biological Process for SPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0010951 negative regulation of endopeptidase activity TAS 7814406
genes like me logo Genes that share ontologies with SPP2: view

No data available for SIGNOR curated interactions for SPP2 Gene

Drugs & Compounds for SPP2 Gene

No Compound Related Data Available

Transcripts for SPP2 Gene

Unigene Clusters for SPP2 Gene

Secreted phosphoprotein 2, 24kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPP2 Gene

No ASD Table

Relevant External Links for SPP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPP2 Gene

mRNA expression in normal human tissues for SPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPP2 Gene

This gene is overexpressed in Liver (x52.4).

Protein differential expression in normal tissues from HIPED for SPP2 Gene

This gene is overexpressed in Serum (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPP2 Gene

SOURCE GeneReport for Unigene cluster for SPP2 Gene Hs.444488

mRNA Expression by UniProt/SwissProt for SPP2 Gene

Tissue specificity: Detected in liver and plasma.
genes like me logo Genes that share expression patterns with SPP2: view

Primer Products

No data available for Protein tissue co-expression partners for SPP2 Gene

Orthologs for SPP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPP2 35
  • 76.68 (n)
  • 66.5 (a)
SPP2 36
  • 67 (a)
(Canis familiaris)
Mammalia SPP2 35
  • 77.38 (n)
  • 70.92 (a)
SPP2 36
  • 70 (a)
(Mus musculus)
Mammalia Spp2 35
  • 75.04 (n)
  • 68.34 (a)
Spp2 16
Spp2 36
  • 68 (a)
(Pan troglodytes)
Mammalia SPP2 35
  • 96.84 (n)
  • 94.79 (a)
SPP2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Spp2 35
  • 73.57 (n)
  • 67.68 (a)
(Monodelphis domestica)
Mammalia SPP2 36
  • 49 (a)
(Gallus gallus)
Aves SPP2 36
  • 38 (a)
(Danio rerio)
Actinopterygii SPP2 36
  • 24 (a)
Species with no ortholog for SPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPP2 Gene

Gene Tree for SPP2 (if available)
Gene Tree for SPP2 (if available)

Paralogs for SPP2 Gene

No data available for Paralogs for SPP2 Gene

Variants for SPP2 Gene

Sequence variations from dbSNP and Humsavar for SPP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs34347825 - 234,050,998(+) TCCAT(C/T)CTCCT reference, missense
rs593668 -- 234,058,895(-) CATGT(A/T)GTCTC reference, synonymous-codon
rs607402 -- 234,068,957(-) agact(C/T)tgagc intron-variant
rs613714 -- 234,063,331(-) GGAAA(G/T)TCTTC intron-variant
rs617970 -- 234,054,345(-) AGGGG(A/C)TACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPP2 Gene

Variant ID Type Subtype PubMed ID
nsv834571 CNV Gain 17160897
nsv10224 CNV Loss 18304495

Variation tolerance for SPP2 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPP2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPP2 Gene

Disorders for SPP2 Gene

Relevant External Links for SPP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPP2 Gene

Publications for SPP2 Gene

  1. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. (PMID: 15062857) Bennett C.S. … Dalgleish R. (Matrix Biol. 2004) 3 4 23 67
  2. Assignment of secreted phosphoprotein 24 (SPP2) to human chromosome band 2q37-->qter by in situ hybridization. (PMID: 9533032) Swallow J.E. … Dalgleish R. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. Bone morphogenetic protein-2 activity is regulated by secreted phosphoprotein-24 kd, an extracellular pseudoreceptor, the gene for which maps to a region of the human genome important for bone quality. (PMID: 19375587) Brochmann E.J. … Murray S.S. (Metab. Clin. Exp. 2009) 3 23
  4. The bone matrix protein secreted phosphoprotein 24 kD (Spp24): bone metabolism regulator and starting material for biotherapeutic materials. (PMID: 25339413) Murray S.S. … Brochmann Murray E.J. (Histol. Histopathol. 2015) 3
  5. A carboxy terminal BMP/TGF-I^ binding site in secreted phosphoprotein 24 kD independently affects BMP-2 activity. (PMID: 25418420) Tian H. … Murray S.S. (J. Cell. Biochem. 2015) 3

Products for SPP2 Gene

Sources for SPP2 Gene