Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPP2 Gene

Aliases for SPP2 Gene

  • Secreted Phosphoprotein 2 2 3 4 5
  • Secreted Phosphoprotein 2, 24kDa 2 3
  • Secreted Phosphoprotein 2, 24kD 2 3
  • SPP-24 3 4
  • SPP24 3 4
  • Secreted Phosphoprotein 24 3

External Ids for SPP2 Gene

Previous GeneCards Identifiers for SPP2 Gene

  • GC02P232967
  • GC02P233641
  • GC02P234975
  • GC02P235246
  • GC02P234741
  • GC02P234624
  • GC02P226759

Summaries for SPP2 Gene

Entrez Gene Summary for SPP2 Gene

  • This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]

GeneCards Summary for SPP2 Gene

SPP2 (Secreted Phosphoprotein 2) is a Protein Coding gene. Diseases associated with SPP2 include Retinitis Pigmentosa. Among its related pathways are Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include endopeptidase inhibitor activity and cysteine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPP2 Gene

  • Could coordinate an aspect of bone turnover.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPP2 Gene

Genomics for SPP2 Gene

Regulatory Elements for SPP2 Gene

Enhancers for SPP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F234419 1.7 FANTOM5 Ensembl ENCODE 9.7 +374.2 374194 10.1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF548 FOS ZNF202 TSHZ1 REST USP40 LOC100422710 ARL4C SPP2 LOC105373935 GC02P234330
GH02F234333 1.4 FANTOM5 Ensembl ENCODE 9.5 +284.4 284448 3.0 SIN3A ZEB1 ZNF335 ZNF366 POLR2A RFX1 BHLHE40 REST ZEB2 TSHZ1 ARL4C SPP2 GC02P234330 LOC105373935
GH02F234164 1.1 FANTOM5 Ensembl ENCODE 10.3 +114.7 114689 2.7 GLIS1 EBF1 MAFK NR2F2 ARL4C SPP2 LOC105373932 ENSG00000226442
GH02F234132 1 Ensembl ENCODE 10.8 +84.7 84664 6.2 CTCF TFAP4 ESRRA PKNOX1 JUN CHD4 SIN3A RAD21 GATA3 SCRT2 ARL4C SPP2 ENSG00000226442 LOC105373932
GH02F233989 0.9 FANTOM5 ENCODE 11 -59.8 -59758 2.6 MTA2 IKZF1 MLLT1 TBX21 MAFK EP300 CHD2 SPP2 USP40 ENSG00000237581
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPP2 Gene

Chromosome:
2
Start:
234,050,679 bp from pter
End:
234,077,134 bp from pter
Size:
26,456 bases
Orientation:
Plus strand

Genomic View for SPP2 Gene

Genes around SPP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPP2 Gene

Proteins for SPP2 Gene

  • Protein details for SPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13103-SPP24_HUMAN
    Recommended name:
    Secreted phosphoprotein 24
    Protein Accession:
    Q13103
    Secondary Accessions:
    • A4QMV3
    • Q3B892
    • Q546M5

    Protein attributes for SPP2 Gene

    Size:
    211 amino acids
    Molecular mass:
    24338 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPP2 Gene

Post-translational modifications for SPP2 Gene

  • Phosphorylation sites are present in the extracellular medium.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPP2 Gene

No data available for DME Specific Peptides for SPP2 Gene

Domains & Families for SPP2 Gene

Protein Domains for SPP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13103

UniProtKB/Swiss-Prot:

SPP24_HUMAN :
  • Belongs to the SPP2 family.
Family:
  • Belongs to the SPP2 family.
genes like me logo Genes that share domains with SPP2: view

No data available for Gene Families for SPP2 Gene

Function for SPP2 Gene

Molecular function for SPP2 Gene

GENATLAS Biochemistry:
secreted phosphoprotein2,24kDa,expressed in bone,bovine spp24 homolog
UniProtKB/Swiss-Prot Function:
Could coordinate an aspect of bone turnover.

Gene Ontology (GO) - Molecular Function for SPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 7814406
genes like me logo Genes that share ontologies with SPP2: view
genes like me logo Genes that share phenotypes with SPP2: view

Animal Models for SPP2 Gene

MGI Knock Outs for SPP2:
  • Spp2 tm1(cre/ERT2)Amc

Animal Model Products

  • Taconic Biosciences Mouse Models for SPP2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPP2 Gene

Localization for SPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPP2 gene
Compartment Confidence
extracellular 5
plasma membrane 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0031089 platelet dense granule lumen TAS --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SPP2: view

Pathways & Interactions for SPP2 Gene

genes like me logo Genes that share pathways with SPP2: view

Interacting Proteins for SPP2 Gene

Selected Interacting proteins: Q13103-SPP24_HUMAN for SPP2 Gene via IID

Symbol External ID(s) Details
PITX3

Gene Ontology (GO) - Biological Process for SPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 7814406
GO:0002576 platelet degranulation TAS --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0046849 bone remodeling IEA --
genes like me logo Genes that share ontologies with SPP2: view

No data available for SIGNOR curated interactions for SPP2 Gene

Transcripts for SPP2 Gene

Unigene Clusters for SPP2 Gene

Secreted phosphoprotein 2, 24kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPP2 Gene

No ASD Table

Relevant External Links for SPP2 Gene

GeneLoc Exon Structure for
SPP2
ECgene alternative splicing isoforms for
SPP2

Expression for SPP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPP2 Gene

This gene is overexpressed in Liver (x52.4).

Protein differential expression in normal tissues from HIPED for SPP2 Gene

This gene is overexpressed in Serum (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPP2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPP2 Gene:

SPP2

SOURCE GeneReport for Unigene cluster for SPP2 Gene:

Hs.444488

mRNA Expression by UniProt/SwissProt for SPP2 Gene:

Q13103-SPP24_HUMAN
Tissue specificity: Detected in liver and plasma.
genes like me logo Genes that share expression patterns with SPP2: view

Primer Products

No data available for Protein tissue co-expression partners for SPP2 Gene

Orthologs for SPP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPP2 34 35
  • 96.84 (n)
dog
(Canis familiaris)
Mammalia SPP2 34 35
  • 77.38 (n)
cow
(Bos Taurus)
Mammalia SPP2 34 35
  • 76.68 (n)
mouse
(Mus musculus)
Mammalia Spp2 34 16 35
  • 75.04 (n)
rat
(Rattus norvegicus)
Mammalia Spp2 34
  • 73.57 (n)
oppossum
(Monodelphis domestica)
Mammalia SPP2 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPP2 35
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SPP2 35
  • 24 (a)
OneToOne
Species where no ortholog for SPP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPP2 Gene

ENSEMBL:
Gene Tree for SPP2 (if available)
TreeFam:
Gene Tree for SPP2 (if available)

Paralogs for SPP2 Gene

No data available for Paralogs for SPP2 Gene

Variants for SPP2 Gene

Sequence variations from dbSNP and Humsavar for SPP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10168712 -- 234,053,517(+) GGATG(A/G)TCGAC intron-variant
rs10170519 -- 234,068,385(+) TGTCA(A/G)AATCT intron-variant
rs10171064 -- 234,058,136(+) CTCAC(A/G)ACCAA intron-variant
rs10171587 -- 234,053,441(+) CCAAG(C/T)GCAGT intron-variant
rs10172000 -- 234,054,475(+) AATTC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPP2 Gene

Variant ID Type Subtype PubMed ID
nsv998149 CNV gain 25217958
nsv834571 CNV gain 17160897
nsv10224 CNV loss 18304495
nsv1013712 CNV loss 25217958
esv3594686 CNV loss 21293372
esv3594685 CNV gain 21293372
dgv4190n100 CNV loss 25217958

Variation tolerance for SPP2 Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPP2 Gene

Human Gene Mutation Database (HGMD)
SPP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPP2 Gene

Disorders for SPP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards
Search SPP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPP2

Genetic Association Database (GAD)
SPP2
Human Genome Epidemiology (HuGE) Navigator
SPP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPP2
genes like me logo Genes that share disorders with SPP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPP2 Gene

Publications for SPP2 Gene

  1. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. (PMID: 15062857) Bennett C.S. … Dalgleish R. (Matrix Biol. 2004) 3 4 22 64
  2. Assignment of secreted phosphoprotein 24 (SPP2) to human chromosome band 2q37-->qter by in situ hybridization. (PMID: 9533032) Swallow J.E. … Dalgleish R. (Cytogenet. Cell Genet. 1997) 2 3 22 64
  3. An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. (PMID: 20548944) Hsu Y.H. … Kiel D.P. (PLoS Genet. 2010) 3 46 64
  4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64
  5. Bone morphogenetic protein-2 activity is regulated by secreted phosphoprotein-24 kd, an extracellular pseudoreceptor, the gene for which maps to a region of the human genome important for bone quality. (PMID: 19375587) Brochmann E.J. … Murray S.S. (Metab. Clin. Exp. 2009) 3 22 64

Products for SPP2 Gene

Sources for SPP2 Gene

Content
Loading form....