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Aliases for SPP2 Gene

Aliases for SPP2 Gene

  • Secreted Phosphoprotein 2, 24kDa 2 3
  • Secreted Phosphoprotein 2, 24kD 2 3
  • SPP-24 3 4
  • SPP24 3 4
  • Secreted Phosphoprotein 24 3
  • Secreted Phosphoprotein 2 4

External Ids for SPP2 Gene

Previous GeneCards Identifiers for SPP2 Gene

  • GC02P232967
  • GC02P233641
  • GC02P234975
  • GC02P235246
  • GC02P234741
  • GC02P234624
  • GC02P226759

Summaries for SPP2 Gene

Entrez Gene Summary for SPP2 Gene

  • This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]

GeneCards Summary for SPP2 Gene

SPP2 (Secreted Phosphoprotein 2, 24kDa) is a Protein Coding gene. GO annotations related to this gene include endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for SPP2 Gene

  • Could coordinate an aspect of bone turnover.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPP2 Gene

Genomics for SPP2 Gene

Regulatory Elements for SPP2 Gene

Genomic Location for SPP2 Gene

234,050,679 bp from pter
234,077,134 bp from pter
26,456 bases
Plus strand

Genomic View for SPP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPP2 Gene

Proteins for SPP2 Gene

  • Protein details for SPP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Secreted phosphoprotein 24
    Protein Accession:
    Secondary Accessions:
    • A4QMV3
    • Q3B892
    • Q546M5

    Protein attributes for SPP2 Gene

    211 amino acids
    Molecular mass:
    24338 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPP2 Gene

Proteomics data for SPP2 Gene at MOPED

Post-translational modifications for SPP2 Gene

  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPP2 Gene

Domains for SPP2 Gene

Protein Domains for SPP2 Gene


Suggested Antigen Peptide Sequences for SPP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q13103
  • Belongs to the SPP2 family.
genes like me logo Genes that share domains with SPP2: view

No data available for Gene Families for SPP2 Gene

Function for SPP2 Gene

Molecular function for SPP2 Gene

GENATLAS Biochemistry: secreted phosphoprotein2,24kDa,expressed in bone,bovine spp24 homolog
UniProtKB/Swiss-Prot Function: Could coordinate an aspect of bone turnover.

Gene Ontology (GO) - Molecular Function for SPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004866 endopeptidase inhibitor activity TAS 7814406
GO:0004869 cysteine-type endopeptidase inhibitor activity --
genes like me logo Genes that share ontologies with SPP2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPP2 Gene

Localization for SPP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPP2 Gene


Subcellular locations from

Jensen Localization Image for SPP2 Gene COMPARTMENTS Subcellular localization image for SPP2 gene
Compartment Confidence
extracellular 5
cytosol 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0043234 protein complex IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SPP2: view

Pathways for SPP2 Gene

SuperPathways for SPP2 Gene

No Data Available

Interacting Proteins for SPP2 Gene

Gene Ontology (GO) - Biological Process for SPP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 7814406
GO:0006461 protein complex assembly IEA --
GO:0010951 negative regulation of endopeptidase activity TAS 7814406
GO:0046849 bone remodeling IEA --
genes like me logo Genes that share ontologies with SPP2: view

No data available for Pathways by source for SPP2 Gene

Transcripts for SPP2 Gene

Unigene Clusters for SPP2 Gene

Secreted phosphoprotein 2, 24kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPP2 Gene

No ASD Table

Relevant External Links for SPP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPP2 Gene

mRNA expression in normal human tissues for SPP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPP2 Gene

This gene is overexpressed in Liver (52.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPP2 Gene

SOURCE GeneReport for Unigene cluster for SPP2 Gene Hs.444488

mRNA Expression by UniProt/SwissProt for SPP2 Gene

Tissue specificity: Detected in liver and plasma.
genes like me logo Genes that share expressions with SPP2: view

In Situ Assay Products

Orthologs for SPP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SPP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPP2 35
  • 96.84 (n)
  • 94.79 (a)
SPP2 36
  • 98 (a)
(Bos Taurus)
Mammalia SPP2 35
  • 76.68 (n)
  • 66.5 (a)
SPP2 36
  • 67 (a)
(Canis familiaris)
Mammalia SPP2 35
  • 77.38 (n)
  • 70.92 (a)
SPP2 36
  • 70 (a)
(Mus musculus)
Mammalia Spp2 35
  • 75.04 (n)
  • 68.34 (a)
Spp2 16
Spp2 36
  • 68 (a)
(Monodelphis domestica)
Mammalia SPP2 36
  • 49 (a)
(Rattus norvegicus)
Mammalia Spp2 35
  • 73.57 (n)
  • 67.68 (a)
(Gallus gallus)
Aves SPP2 36
  • 38 (a)
(Danio rerio)
Actinopterygii SPP2 36
  • 24 (a)
Species with no ortholog for SPP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPP2 Gene

Gene Tree for SPP2 (if available)
Gene Tree for SPP2 (if available)

Paralogs for SPP2 Gene

No data available for Paralogs for SPP2 Gene

Variants for SPP2 Gene

Sequence variations from dbSNP and Humsavar for SPP2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs250968 -- 234,077,467(-) gaggc(A/G)gagct downstream-variant-500B
rs250969 -- 234,077,423(-) gcctg(A/G)gtgac downstream-variant-500B
rs250970 -- 234,076,217(-) AGCAC(G/T)CAAGG intron-variant
rs250971 -- 234,076,187(-) ACTGT(C/T)GGGTG intron-variant
rs250972 -- 234,074,881(-) tgtgt(C/T)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPP2 Gene

Variant ID Type Subtype PubMed ID
nsv834571 CNV Gain 17160897
nsv10224 CNV Loss 18304495

Relevant External Links for SPP2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPP2 Gene

Disorders for SPP2 Gene

Relevant External Links for SPP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPP2: view

No data available for UniProtKB/Swiss-Prot for SPP2 Gene

Publications for SPP2 Gene

  1. Assignment of secreted phosphoprotein 24 (SPP2) to human chromosome band 2q37-->qter by in situ hybridization. (PMID: 9533032) Swallow J.E. … Dalgleish R. (Cytogenet. Cell Genet. 1997) 2 3 23
  2. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. (PMID: 15062857) Bennett C.S. … Dalgleish R. (Matrix Biol. 2004) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48

Products for SPP2 Gene

Sources for SPP2 Gene

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