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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPP2 Gene

protein-coding   GIFtS: 48
GCID: GC02P234975

secreted phosphoprotein 2, 24kDa

(Previous names: secreted phosphoprotein 2, 24kD )
 Explore 1 disease affiliated with
SPP2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPP2    

Aliases
for SPP2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Secreted Phosphoprotein 2, 24kDa1 2     Secreted Phosphoprotein 242
SPP241 2 3     Spp-243
Secreted Phosphoprotein 2, 24kD1     Secreted Phosphoprotein 23
SPP-242     

External Ids:    HGNC: 112561   Entrez Gene: 66942   Ensembl: ENSG000000720807   OMIM: 6026375   UniProtKB: Q131033   

Export aliases for SPP2 gene to outside databases

Previous GC identifers: GC02P232967 GC02P233641 GC02P235246 GC02P234741 GC02P234624 GC02P226759


Summaries
for SPP2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPP2:
This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. (provided by RefSeq, Oct
2008)

UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103
Function: Could coordinate an aspect of bone turnover (By similarity)




Genomic Views
for SPP2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPP2 gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   GCNF   E2F-2   E2F-1   E2F   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.1   Ensembl cytogenetic band:  2q37.1   HGNC cytogenetic band: 2q37.1

SPP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPP2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P234975:  view genomic region     (about GC identifiers)

Start:
 234,959,323 bp from pter      End:
 234,985,778 bp from pter
Size:
 26,456 bases      Orientation:
 plus strand

Proteins
for SPP2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103 (See protein sequence)
Recommended Name: Secreted phosphoprotein 24 precursor  
Size: 211 amino acids; 24338 Da
Subcellular location: Secreted
Developmental stage: Found in fetal liver and kidney
Secondary accessions: A4QMV3 Q3B892 Q546M5

Explore the universe of human proteins at neXtProt for SPP2: NX_Q13103

Post-translational modifications:

  • Phosphorylation sites are present in the extracellular medium1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13103

    • SPP2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008875.1  
    ENSEMBL proteins: 
     ENSP00000362466   ENSP00000168148   ENSP00000417036  

    Human Recombinant Protein Products: 
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    Uscn Proteins for SPP2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0043234protein complex IEA--


    SPP2 for ontologies           About GeneDecksing



    SPP2 Antibody Products: 
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    Uscn Antibodies for SPP2
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    Uscn ELISAs and CLIAs for SPP2

    Protein Domains /
    Families
    for SPP2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPP2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR010892 Spp-24

    Graphical View of Domain Structure for InterPro Entry Q13103

    ProtoNet protein and cluster: Q13103

    1 Blocks protein family: IPB010892 Secreted phosphoprotein 24

    UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103
    Similarity: Belongs to the SPP2 family


    Function
    for SPP2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103
    Function: Could coordinate an aspect of bone turnover (By similarity)

         Genatlas biochemistry entry for SPP2:
    secreted phosphoprotein2,24kDa,expressed in bone,bovine spp24 homolog

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPP2
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    SwitchGear 3'UTR luciferase reporter plasmid: SPP2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPP2 (see all 7)
    OriGene shRNA RFP: SPP2
    OriGene siRNA: SPP2
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPP2 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: SPP2 (NM_006944)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPP2 

    Cell Line
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    Search LifeMap BioReagents cell lines for SPP2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPP2

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004866endopeptidase inhibitor activity TAS7814406


    SPP2 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SPP2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPP2

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS7814406
    GO:0006461protein complex assembly IEA--
    GO:0010951negative regulation of endopeptidase activity TAS7814406
    GO:0046849bone remodeling IEA--


    SPP2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPP2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPP2
    Search CenterWatch for drugs/clinical trials and news about SPP2 / SPP24 

    Transcripts
    for SPP2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPP2 gene: 
    NM_006944.2  

    Unigene Cluster for SPP2:

    Secreted phosphoprotein 2, 24kDa
    Hs.444488  [show with all ESTs]
    Unigene Representative Sequence: NM_006944
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373368(uc010fyl.1) ENST00000168148(uc002vvk.1) ENST00000425558
    ENST00000492481

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPP2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SPP2
    SwitchGear 3'UTR luciferase reporter plasmid: SPP2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPP2 (see all 7)
    OriGene shRNA RFP: SPP2
    OriGene siRNA: SPP2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPP2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPP2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPP2 (NM_006944)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPP2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPP2

    Additional cDNA sequence: 

    AJ308099.1 BC069401.1 BC106705.1 BC112438.1 BC113972.1 U20530.1 

    4 DOTS entries:

    DT.453598  DT.92417474  DT.92417475  DT.91943145 

    24/31 AceView cDNA sequences (see all 31):

    AJ308099 BX405937 BX097970 AV718912 CR607621 N74450 BX496642 AV656125 
    U20530 NM_006944 CB164241 AW119013 AV645964 AW340137 CB163851 BC069401 
    N54053 AI005085 R29227 AI221684 AI032584 W03162 BE971485 H59135 

    GeneLoc Exon Structure


    Expression
    for SPP2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCACGGTGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPP2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    KidneyProximal TubuleProximal Tubule CellsKidney
    KidneyEpithelial TubuleKidney
    KidneyMetanephrosKidney
    KidneyProximal TubuleKidney
    LiverLiver LobuleLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPP2

    SOURCE GeneReport for Unigene cluster: Hs.444488

    UniProtKB/Swiss-Prot: SPP24_HUMAN, Q13103
    Tissue specificity: Detected in liver and plasma

        SABiosciences Custom PCR Arrays for SPP2
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPP2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPP2

    Orthologs
    for SPP2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for SPP2 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Spp21 , 5 secreted phosphoprotein 21, 5 75.71(n)1
    69.35(a)1    		   1 (44.63 cM)5
    753961  NM_029269.21  NP_083545.11 
     884069615 
    chicken
    (Gallus gallus)    		 Aves SPP26
    		 secreted phosphoprotein 24
    		 38(a)
    		 1 ↔ 1
    		 7(5598689-5608914)
    zebrafish
    (Danio rerio)    		 Actinopterygii si:dkey-1h24.46
    		 si:dkey-1h24.4
    		 23(a)
    		 1 ↔ 1
    		 1(28688682-28692942)


    ENSEMBL Gene Tree for SPP2 (if available)
    TreeFam Gene Tree for SPP2 (if available) 

    Paralogs
    for SPP2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SPP2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/657 NCBI SNPs in SPP2 are shown (see all 657)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289036981,2
    		C,H,--226757296(+) GTATAA/CGGTGT 1 -- us2k1 tfbs33Minor allele frequency- C:0.00NS EA 296
    rs104515381,2
    		C,--226757583(+) actttT/Cacact 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs124776511,2
    		C,H--226758094(+) atgtaG/Tatgat 1 -- us2k11Minor allele frequency- T:0.00EA 176
    rs133917341,2
    		C,F,H,--226758193(+) tatatA/Gtttaa 1 -- us2k15Minor allele frequency- G:0.07NS EA 538
    rs739994191,2
    		C,--226758665(+) GACCCC/TTATAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs15075161,2
    		C,F,H,--226760271(+) CCCATC/ACCTCC 1 -- int110Minor allele frequency- A:0.00EA NA MN NS 926
    rs771600381,2
    		C,F,--226760599(+) TCCTGG/AATCAG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs289039861,2
    		C,F,H,--226760661(+) ATTGGC/TATTTA 1 -- int17Minor allele frequency- T:0.03NS EA NA WA 540
    rs67318231,2
    		C,F,H,--226760860(+) GAGATG/AAGCTA 1 -- int16Minor allele frequency- A:0.01NS EA CSA 600
    rs289039871,2
    		C,F,H,--226760868(+) CTATTG/TTGAGG 1 -- int17Minor allele frequency- T:0.02NS EA NA WA 540

    HapMap Linkage Disequilibrium report for SPP2 (234959323 - 234985778 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for SPP2
         2 CNVs: 32398 90343
    Human Gene Mutation Database (HGMD): SPP2

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPP2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPP2

    Disorders / Diseases
    for SPP2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPP2 for disorders           About GeneDecksing

    OMIM gene information: 602637    OMIM disorders: --

    1 disease for SPP2:    About MalaCards
    osteoporosis

    Human Genome Epidemiology (HuGE) Navigator: SPP2 (1 document)

    Export disorders for SPP2 gene to outside databases

    Publications
    for SPP2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPP2 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SPP2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human secreted phosphoprotein 24 gene (SPP2) and comparison of the protein sequence in nine species. (PubMed id 15062857)1, 2, 9 Bennett C.S....Dalgleish R. (2004)
    2. Assignment of secreted phosphoprotein 24 (SPP2) to human chromosome band 2q37-->qter by in situ hybridization. (PubMed id 9533032)1, 3, 9 Swallow J.E....Dalgleish R. (1997)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Bone morphogenetic protein-2 activity is regulated by secreted phosphoprotein-24 kd, an extracellular pseudoreceptor, the gene for which maps to a region of the human genome important for bone quality. (PubMed id 19375587)1, 9 Brochmann E.J....Murray S.S. (2009)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. An integration of genome-wide association study and g ene expression profiling to prioritize the discovery of novel susceptibility Lo ci for osteoporosis-related traits. (PubMed id 20548944)1 Hsu Y.H....Kiel D.P. (2010)
    8. Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for SPP2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SPP2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6694 HGNC: 11256 AceView: SPP2 Ensembl:ENSG00000072080 euGenes: HUgn6694
    ECgene: SPP2 H-InvDB: SPP2

    Other Databases showing SPP2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPP2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPP2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPP2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPP2 gene:
    Search GeneIP for patents involving SPP2

    GeneCards and IP:
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     SPP2 Proteins, Antibodies, CLIAs, and ELISAs
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