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Aliases for SPP1 Gene

Aliases for SPP1 Gene

  • Secreted Phosphoprotein 1 2 3 4
  • OPN 3 4 6
  • Early T-Lymphocyte Activation 1 2 3
  • Urinary Stone Protein 3 4
  • Nephropontin 3 4
  • Osteopontin 2 3
  • Uropontin 3 4
  • BNSP 3 4
  • Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-Lymphocyte Activation 1) 3
  • Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein 3
  • Bone Sialoprotein I 2
  • SPP1/CALPHA1 Fusion 3
  • Bone Sialoprotein 1 4
  • ETA-1 3
  • SPP-1 4
  • BSPI 3

External Ids for SPP1 Gene

Previous Symbols for SPP1 Gene

  • BNSP
  • OPN

Summaries for SPP1 Gene

Entrez Gene Summary for SPP1 Gene

  • The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPP1 Gene

SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include tendinitis and calcific tendinitis. Among its related pathways are PI3K-Akt signaling pathway and Signaling by FGFR. GO annotations related to this gene include cytokine activity and extracellular matrix binding.

UniProtKB/Swiss-Prot for SPP1 Gene

  • Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction

  • Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Gene Wiki entry for SPP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPP1 Gene

Genomics for SPP1 Gene

Genomic Location for SPP1 Gene

Start:
87,975,650 bp from pter
End:
87,983,426 bp from pter
Size:
7,777 bases
Orientation:
Plus strand

Genomic View for SPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPP1 Gene

Regulatory Elements for SPP1 Gene

Transcription factor binding sites by QIAGEN in the SPP1 gene promoter:

Proteins for SPP1 Gene

  • Protein details for SPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10451-OSTP_HUMAN
    Recommended name:
    Osteopontin
    Protein Accession:
    P10451
    Secondary Accessions:
    • B2RDA1
    • Q15681
    • Q15682
    • Q15683
    • Q4W597
    • Q567T5
    • Q8NBK2
    • Q96IZ1

    Protein attributes for SPP1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35423 Da
    Quaternary structure:
    • Ligand for integrin alpha-V/beta-3

    Three dimensional structures from OCA and Proteopedia for SPP1 Gene

    Alternative splice isoforms for SPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPP1 Gene

Proteomics data for SPP1 Gene at MOPED

Post-translational modifications for SPP1 Gene

  • Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.
  • N- and O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn79, Asn106, Thr134, Thr138, Thr143, Thr147, and Thr152

Other Protein References for SPP1 Gene

No data available for DME Specific Peptides for SPP1 Gene

Domains for SPP1 Gene

Gene Families for SPP1 Gene

HGNC:

Protein Domains for SPP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P10451

UniProtKB/Swiss-Prot:

OSTP_HUMAN
Family:
  • Belongs to the osteopontin family.:
    • P10451
genes like me logo Genes that share domains with SPP1: view

Function for SPP1 Gene

Molecular function for SPP1 Gene

GENATLAS Biochemistry: secreted phosphoprotein 1 (osteopontin),regulated by CBFA1 and ETS1 in the skeletal tissue
UniProtKB/Swiss-Prot Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction
UniProtKB/Swiss-Prot Function: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Gene Ontology (GO) - Molecular Function for SPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with SPP1: view
genes like me logo Genes that share phenotypes with SPP1: view

Animal Models for SPP1 Gene

MGI Knock Outs for SPP1:

miRNA for SPP1 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPP1 Gene

Localization for SPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPP1 Gene COMPARTMENTS Subcellular localization image for SPP1 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
plasma membrane 2
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 15516325
GO:0005737 cytoplasm --
GO:0031988 membrane-bounded vesicle --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with SPP1: view

Pathways for SPP1 Gene

genes like me logo Genes that share pathways with SPP1: view

Gene Ontology (GO) - Biological Process for SPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification --
GO:0001649 osteoblast differentiation IEA --
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion IEA --
GO:0007566 embryo implantation TAS 16720713
genes like me logo Genes that share ontologies with SPP1: view

Compounds for SPP1 Gene

(110) Novoseek inferred chemical compound relationships for SPP1 Gene

Compound -log(P) Hits PubMed IDs
calcium oxalate 78.9 73
grgds 76.3 26
alizarin 75.8 6
hydroxyapatite 74.7 93
1,25 dihydroxy vitamin d3 60.5 12
genes like me logo Genes that share compounds with SPP1: view

Transcripts for SPP1 Gene

Unigene Clusters for SPP1 Gene

Secreted phosphoprotein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - - -

Relevant External Links for SPP1 Gene

GeneLoc Exon Structure for
SPP1
ECgene alternative splicing isoforms for
SPP1

Expression for SPP1 Gene

mRNA expression in normal human tissues for SPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPP1 Gene

This gene is overexpressed in Kidney - Cortex (18.1), Brain - Spinal cord (cervical c-1) (9.2), and Brain - Substantia nigra (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPP1 Gene

SOURCE GeneReport for Unigene cluster for SPP1 Gene Hs.313

mRNA Expression by UniProt/SwissProt for SPP1 Gene

P10451-OSTP_HUMAN
Tissue specificity: Bone. Found in plasma
genes like me logo Genes that share expressions with SPP1: view

Orthologs for SPP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPP1 35
  • 99.04 (n)
  • 97.77 (a)
SPP1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPP1 35
  • 80.1 (n)
  • 69.78 (a)
SPP1 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPP1 35
  • 77.03 (n)
  • 63.21 (a)
SPP1 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spp1 35
  • 72.77 (n)
  • 66.1 (a)
Spp1 16
Spp1 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPP1 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPP1 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spp1 35
  • 73.58 (n)
  • 66.56 (a)
Species with no ortholog for SPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPP1 Gene

ENSEMBL:
Gene Tree for SPP1 (if available)
TreeFam:
Gene Tree for SPP1 (if available)

Paralogs for SPP1 Gene

Selected SIMAP similar genes for SPP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPP1: view

No data available for Paralogs for SPP1 Gene

Variants for SPP1 Gene

Sequence variations from dbSNP and Humsavar for SPP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4660 - 87,982,853(+) ATTTC(A/G)TATTT missense, reference
rs4754 -- 87,981,540(+) GATGA(C/T)GACCA synonymous-codon, reference
rs9138 -- 87,983,190(+) GTAGA(A/C)GCAAA utr-variant-3-prime
rs1126616 -- 87,982,701(+) AAAGC(C/G/T)AATGA reference, synonymous-codon
rs1126772 -- 87,983,034(+) TAACT(A/G)ATGTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPP1 Gene

Variant ID Type Subtype PubMed ID
nsv7364 OTHER Inversion 18451855
esv2665331 CNV Deletion 23128226

Relevant External Links for SPP1 Gene

HapMap Linkage Disequilibrium report
SPP1
Human Gene Mutation Database (HGMD)
SPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPP1 Gene

Disorders for SPP1 Gene

(98) Novoseek inferred disease relationships for SPP1 Gene

Disease -log(P) Hits PubMed IDs
calcification 77.6 196
metastasis 64.3 215
dentinogenesis imperfecta 63.3 2
renal stone 62.9 29
urinary stones 59.8 35

Relevant External Links for SPP1

Genetic Association Database (GAD)
SPP1
Human Genome Epidemiology (HuGE) Navigator
SPP1
genes like me logo Genes that share disorders with SPP1: view

No data available for UniProtKB/Swiss-Prot for SPP1 Gene

Publications for SPP1 Gene

  1. Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin. (PMID: 1575754) Kohri K. … Kurita T. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. (PMID: 1729712) Shiraga H. … Hoyer J.R. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  3. Expression of osteopontin in human glioma. Its correlation with the malignancy. (PMID: 7837791) Saitoh Y. … Ushio Y. (Lab. Invest. 1995) 3 4 23
  4. Genomic organization of the human osteopontin gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II. (PMID: 7665163) Crosby A.H. … Dixon M.J. (Genomics 1995) 3 4 23
  5. An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus. (PMID: 11933203) Forton A.C. … Sullivan K.E. (Hum. Mutat. 2002) 3 23 48

Products for SPP1 Gene

  • Addgene plasmids for SPP1

Sources for SPP1 Gene

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