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Aliases for SPP1 Gene

Aliases for SPP1 Gene

  • Secreted Phosphoprotein 1 2 3 4 5
  • Early T-Lymphocyte Activation 1 2 3
  • Urinary Stone Protein 3 4
  • Nephropontin 3 4
  • Osteopontin 2 3
  • Uropontin 3 4
  • BNSP 3 4
  • OPN 3 4
  • Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-Lymphocyte Activation 1) 3
  • Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein 3
  • Secreted Phosphoprotein 1 Variant 6 3
  • Bone Sialoprotein I 2
  • SPP1/CALPHA1 Fusion 3
  • Bone Sialoprotein 1 4
  • ETA-1 3
  • SPP-1 4
  • BSPI 3

External Ids for SPP1 Gene

Previous HGNC Symbols for SPP1 Gene

  • BNSP
  • OPN

Previous GeneCards Identifiers for SPP1 Gene

  • GC04P089054
  • GC04P089198
  • GC04P089355
  • GC04P089253
  • GC04P089115
  • GC04P088896
  • GC04P084643

Summaries for SPP1 Gene

Entrez Gene Summary for SPP1 Gene

  • The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPP1 Gene

SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Malignant Pleural Mesothelioma and Pediatric Systemic Lupus Erythematosus. Among its related pathways are Transcription_Role of VDR in regulation of genes involved in osteoporosis and Phospholipase-C Pathway. GO annotations related to this gene include cytokine activity and extracellular matrix binding.

UniProtKB/Swiss-Prot for SPP1 Gene

  • Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.

  • Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Gene Wiki entry for SPP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPP1 Gene

Genomics for SPP1 Gene

Regulatory Elements for SPP1 Gene

Enhancers for SPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G087909 1.4 Ensembl ENCODE dbSUPER 19.3 -64.4 -64405 3.7 FOXA2 MLX ARID4B YY1 PPARG KAT8 SSRP1 SMARCA4 RCOR2 ETV4 SPP1 PKD2 MEPE PIR37483
GH04G087843 1.2 FANTOM5 Ensembl ENCODE 21.1 -131.4 -131388 1.0 JUND JUN BHLHE40 SIN3A FOSL2 FOS REST SPP1 MEPE PKD2 HSD17B11 HSP90AB3P
GH04G087849 1 FANTOM5 Ensembl 22.2 -125.8 -125764 0.6 SMARCE1 RUNX1 CEBPA HMBOX1 CEBPB CEBPG MYC GABPA SPP1 IBSP HSD17B11 MEPE HSP90AB3P
GH04G087895 1.3 FANTOM5 Ensembl ENCODE 15.7 -79.1 -79082 1.6 GTF2F1 JUN CEBPG SMC3 RCOR1 FOS TCF7L2 CHD2 CEBPB ZNF398 SPP1 PKD2 HSP90AB3P PIR37483
GH04G087916 1 ENCODE dbSUPER 19 -56.1 -56127 5.8 TAL1 CHD1 MAFG FEZF1 OSR2 ZNF316 JUND POLR2A SMARCA4 POU5F1 SPP1 MEPE PIR37483
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPP1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SPP1 gene promoter:

Genomic Location for SPP1 Gene

Chromosome:
4
Start:
87,975,650 bp from pter
End:
87,983,426 bp from pter
Size:
7,777 bases
Orientation:
Plus strand

Genomic View for SPP1 Gene

Genes around SPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPP1 Gene

Proteins for SPP1 Gene

  • Protein details for SPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10451-OSTP_HUMAN
    Recommended name:
    Osteopontin
    Protein Accession:
    P10451
    Secondary Accessions:
    • B2RDA1
    • Q15681
    • Q15682
    • Q15683
    • Q4W597
    • Q567T5
    • Q8NBK2
    • Q96IZ1

    Protein attributes for SPP1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35423 Da
    Quaternary structure:
    • Ligand for integrin alpha-V/beta-3.

    Three dimensional structures from OCA and Proteopedia for SPP1 Gene

    Alternative splice isoforms for SPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPP1 Gene

Post-translational modifications for SPP1 Gene

  • Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif.
  • N- and O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.
  • Glycosylation at Asn79, Asn106, posLast=134134, Thr138, posLast=143143, isoforms=5, 2, 3, 4147, and Thr152
  • Modification sites at PhosphoSitePlus

Assay Products

  • Enzo Life Sciences assays for SPP1

No data available for DME Specific Peptides for SPP1 Gene

Domains & Families for SPP1 Gene

Gene Families for SPP1 Gene

Protein Domains for SPP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P10451

UniProtKB/Swiss-Prot:

OSTP_HUMAN :
  • Belongs to the osteopontin family.
Family:
  • Belongs to the osteopontin family.
genes like me logo Genes that share domains with SPP1: view

Function for SPP1 Gene

Molecular function for SPP1 Gene

GENATLAS Biochemistry:
secreted phosphoprotein 1 (osteopontin),regulated by CBFA1 and ETS1 in the skeletal tissue
UniProtKB/Swiss-Prot Function:
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
UniProtKB/Swiss-Prot Function:
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

Gene Ontology (GO) - Molecular Function for SPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 16189514
GO:0050840 extracellular matrix binding IBA --
genes like me logo Genes that share ontologies with SPP1: view
genes like me logo Genes that share phenotypes with SPP1: view

Animal Models for SPP1 Gene

MGI Knock Outs for SPP1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPP1

CRISPR Products

miRNA for SPP1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPP1 Gene

Localization for SPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPP1 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
cytoskeleton 2
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA,IDA 15516325
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IDA --
GO:0031982 vesicle IEA --
genes like me logo Genes that share ontologies with SPP1: view

Pathways & Interactions for SPP1 Gene

genes like me logo Genes that share pathways with SPP1: view

SIGNOR curated interactions for SPP1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for SPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IBA --
GO:0006710 androgen catabolic process IDA 26482249
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion IBA --
GO:0007566 embryo implantation TAS 16720713
genes like me logo Genes that share ontologies with SPP1: view

Drugs & Compounds for SPP1 Gene

(59) Drugs for SPP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(51) Additional Compounds for SPP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPP1: view

Transcripts for SPP1 Gene

Unigene Clusters for SPP1 Gene

Secreted phosphoprotein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6: - - - -

Relevant External Links for SPP1 Gene

GeneLoc Exon Structure for
SPP1
ECgene alternative splicing isoforms for
SPP1

Expression for SPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPP1 Gene

This gene is overexpressed in Kidney - Cortex (x18.1), Brain - Spinal cord (cervical c-1) (x9.2), and Brain - Substantia nigra (x5.7).

Protein differential expression in normal tissues from HIPED for SPP1 Gene

This gene is overexpressed in Urine (29.6), Milk (15.5), Amniocyte (10.7), and Cerebrospinal fluid (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPP1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPP1 Gene:

SPP1

SOURCE GeneReport for Unigene cluster for SPP1 Gene:

Hs.313

mRNA Expression by UniProt/SwissProt for SPP1 Gene:

P10451-OSTP_HUMAN
Tissue specificity: Bone. Found in plasma.

Evidence on tissue expression from TISSUES for SPP1 Gene

  • Kidney(5)
  • Nervous system(5)
  • Liver(4.7)
  • Pancreas(4.5)
  • Bone(4.3)
  • Lung(4.3)
  • Blood(3.8)
  • Eye(3.8)
  • Gall bladder(3.1)
  • Heart(2.9)
  • Muscle(2.8)
  • Skin(2.8)
  • Bone marrow(2.6)
  • Intestine(2.6)
  • Lymph node(2.3)
  • Urine(2.1)
genes like me logo Genes that share expression patterns with SPP1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPP1 Gene

Orthologs for SPP1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPP1 34 35
  • 99.04 (n)
cow
(Bos Taurus)
Mammalia SPP1 34 35
  • 80.1 (n)
dog
(Canis familiaris)
Mammalia SPP1 34 35
  • 77.03 (n)
rat
(Rattus norvegicus)
Mammalia Spp1 34
  • 73.58 (n)
mouse
(Mus musculus)
Mammalia Spp1 34 16 35
  • 72.77 (n)
oppossum
(Monodelphis domestica)
Mammalia SPP1 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPP1 35
  • 50 (a)
OneToOne
Species where no ortholog for SPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPP1 Gene

ENSEMBL:
Gene Tree for SPP1 (if available)
TreeFam:
Gene Tree for SPP1 (if available)

Paralogs for SPP1 Gene

(1) SIMAP similar genes for SPP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPP1: view

No data available for Paralogs for SPP1 Gene

Variants for SPP1 Gene

Sequence variations from dbSNP and Humsavar for SPP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000203079 -- 87,982,283(+) CATAT(C/G)TAAGT intron-variant
rs1000274104 -- 87,976,190(+) AATGA(C/T)GTATC intron-variant, upstream-variant-2KB
rs1000542175 -- 87,983,794(+) GATTC(C/T)ACATA downstream-variant-500B
rs1001010225 -- 87,977,596(+) GCTGA(A/T)GTTAG intron-variant, utr-variant-5-prime
rs1001531751 -- 87,973,891(+) TCATA(C/T)TGAAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPP1 Gene

Variant ID Type Subtype PubMed ID
esv2665331 CNV deletion 23128226
esv3893976 CNV loss 25118596
nsv7364 OTHER inversion 18451855

Variation tolerance for SPP1 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPP1 Gene

Human Gene Mutation Database (HGMD)
SPP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPP1 Gene

Disorders for SPP1 Gene

MalaCards: The human disease database

(51) MalaCards diseases for SPP1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
malignant pleural mesothelioma
  • malignant mesothelioma of pleura
pediatric systemic lupus erythematosus
  • sle, pediatric onset
dentin dysplasia
  • dentinal dysplasia
tendinitis
  • tendinopathy
calcific tendinitis
- elite association - COSMIC cancer census association via MalaCards
Search SPP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPP1

Genetic Association Database (GAD)
SPP1
Human Genome Epidemiology (HuGE) Navigator
SPP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPP1
genes like me logo Genes that share disorders with SPP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPP1 Gene

Publications for SPP1 Gene

  1. The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis. (PMID: 20219412) Chiu Y.W. … Kao S.Y. (Oral Oncol. 2010) 3 22 46 64
  2. The impact of osteopontin promoter polymorphisms on the risk of calcium urolithiasis. (PMID: 20144595) Liu C.C. … Wu M.T. (Clin. Chim. Acta 2010) 3 22 46 64
  3. Association between osteopontin and human abdominal aortic aneurysm. (PMID: 17170369) Golledge J. … Norman P.E. (Arterioscler. Thromb. Vasc. Biol. 2007) 3 22 46 64
  4. Post-translationally modified residues of native human osteopontin are located in clusters: identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. (PMID: 15869464) Christensen B. … Sorensen E.S. (Biochem. J. 2005) 3 4 22 64
  5. A polymorphism of the osteopontin gene is related to urinary calcium stones. (PMID: 16145474) Gao B. … Kohri K. (J. Urol. 2005) 3 22 46 64

Products for SPP1 Gene

  • Addgene plasmids for SPP1

Sources for SPP1 Gene

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