Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPP1 Gene

protein-coding GIFtS: 73
GCID: GC04P088896

secreted phosphoprotein 1

(Previous names: osteopontin, bone sialoprotein I )
(Previous symbols: BNSP, OPN)

Explore 232 diseases affiliated with
SPP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Secreted Phosphoprotein 1¹ ² ³		Nephropontin³
OPN¹ ² ³ ⁵		Osteopontin/Immunoglobulin Alpha 1 Heavy Chain Constant Region Fusion Protein²
BNSP¹ ² ³		Secreted Phosphoprotein 1 (Osteopontin, Bone Sialoprotein I, Early T-Lymphocyte Activation 1)²
BSPI¹ ²		SPP1/CALPHA1 Fusion²
ETA-1¹ ²		Uropontin³
Osteopontin¹		Nephropontin³
Urinary Stone Protein² ³		SPP-1³
Bone Sialoprotein I¹		Uropontin³
Early T-Lymphocyte Activation 1²		Bone Sialoprotein 1³

External Ids:	HGNC: 11255¹	Entrez Gene: 6696²	Ensembl: ENSG00000118785⁷	OMIM: 166490⁵	UniProtKB: P10451³

Export aliases for SPP1 gene to outside databases

Previous GC identifers: GC04P089054 GC04P089198 GC04P089355 GC04P089253 GC04P089115 GC04P084643

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPP1:

The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The

encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found

in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that

upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms

have been found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably

important to cell-matrix interaction

Function: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing

production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity)

Gene Wiki entry for SPP1 (Osteopontin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_016354.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPP1 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SPP1 promoter sequence

Search SABiosciences Chromatin IP Primers for SPP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q22.1 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q22.1

SPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPP1 gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P088896: view genomic region (about GC identifiers)

Start:	88,896,802 bp from pter	End:	88,904,563 bp from pter
Size:	7,762 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451 (See protein sequence)

Recommended Name: Osteopontin precursor

Size: 314 amino acids; 35423 Da

Subunit: Ligand for integrin alpha-V/beta-3

Subcellular location: Secreted

2 PDB 3D structures from and Proteopedia for SPP1:

3CXD (3D)

3DSF (3D)

Secondary accessions: B2RDA1 Q15681 Q15682 Q15683 Q4W597 Q567T5 Q8NBK2 Q96IZ1

Alternative splicing: 5 isoforms: P10451-1 P10451-2 P10451-3 P10451-4 P10451-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPP1: NX_P10451

Post-translational modifications:

Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif¹

N- and O-glycosylated. Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10451

SPP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (5 alternative transcripts):

NP_000573.1 NP_001035147.1 NP_001035149.1 NP_001238758.1 NP_001238759.1

ENSEMBL proteins:

ENSP00000237623 ENSP00000378517 ENSP00000354042 ENSP00000422973

Reactome Protein details: P10451
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for SPP1 (Osteopontin/OPN)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: SPP1 OriGene Protein Over-expression Lysate (see all 3): SPP1 OriGene Custom Protein Services for SPP1
	GenScript Custom Purified and Recombinant Proteins Services for SPP1
	Novus Biologicals SPP1 Proteins Novus Biologicals SPP1 Lysates
	Sino Biological Recombinant Protein for SPP1
	ProSpec Recombinant Protein for SPP1
	Uscn Proteins for SPP1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IDA	15516325
GO:0005737	cytoplasm	--	--
GO:0031988	membrane-bounded vesicle	IEA	--
GO:0042995	cell projection	IEA	--

SPP1 for ontologies About GeneDecksing

SPP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of SPP1
	R&D Systems Antibodies for SPP1 (Osteopontin/OPN)
	OriGene Antibodies (see all 3): SPP1 OriGene Custom Antibody Services for SPP1
	GenScript Custom Superior Antibodies Services for SPP1
	Novus Biologicals SPP1 Antibodies
	Abcam antibodies for SPP1
	Uscn Antibodies for SPP1
	ThermoFisher Antibodies for SPP1

Assay Products for SPP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for SPP1 (Osteopontin/OPN) (see all)
	GenScript Custom Assay Services for SPP1
	Enzo Life Sciences assays for SPP1
	Uscn ELISAs and CLIAs for SPP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPP1 for domains About GeneDecksing

2 InterPro domains/families:

IPR002038 Osteopontin

IPR019841 Osteopontin_CS

Graphical View of Domain Structure for InterPro Entry P10451

ProtoNet protein and cluster: P10451

1 Blocks protein family: IPB002038 Osteopontin

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

Similarity: Belongs to the osteopontin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably

important to cell-matrix interaction

Function: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing

production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity)

Genatlas biochemistry entry for SPP1:

secreted phosphoprotein 1 (osteopontin),regulated by CBFA1 and ETS1 in the skeletal tissue

miRNA Products:		miRTarBase miRNAs that target SPP1: hsa-mir-299-5p (MIRT004565)

		OriGene 3'-UTR Clone (see all 3): SPP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPP1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SPP1:
		hsa-miR-181c hsa-miR-3065-5p hsa-miR-33b hsa-miR-181a hsa-miR-181d hsa-miR-33a hsa-miR-181b hsa-miR-4262

		SwitchGear 3'UTR luciferase reporter plasmid: SPP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPP1 (see all 7) OriGene shRNA RFP: SPP1 OriGene siRNA: SPP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SPP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPP1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPP1 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SPP1 (NM_001040058)
		Sino Biological Human cDNA Clone for SPP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SPP1
		LifeMap BioReagents: cell lines associated with SPP1: Osteogenic Package SK11, Osteogenic Package SM30, PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPP1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0050840	extracellular matrix binding	IEA	--

SPP1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for SPP1:

Decreased CXCL12 induced migra

Decreased viability with pacli

Animal Models:
Mouse knock-outs for SPP1: Spp1^tm1Blh Spp1^tm1Rit
15/17 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Spp1) (see all 17):

behavior/neurological	cardiovascular system	cellular	growth/size	hematopoietic system
homeostasis/metabolism	immune system	integument	liver/biliary system	mortality/aging
muscle	nervous system	renal/urinary system	reproductive system	respiratory system

SPP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

Development_Hedgehog and PTH signaling pathways in bone and cartilage development

1.00

Development Hedgehog and PTH signaling pathways in bone and cartilage development

0.97

PTEN Pathway

PTEN Pathway

1.00

Phospholipase-C Pathway

0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for SPP1

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Transcription Role of VDR in regulation of genes involved in osteoporosis

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SPP1 (see all 15)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	PI3K Signaling in B-Lymphocyte
	Transendothelial Migration of Leukocytes

2 GeneGo (Thomson Reuters) Pathways for SPP1

	Development Hedgehog and PTH signaling pathways in bone and cartilage development
	Transcription Role of VDR in regulation of genes involved in osteoporosis

5/10 BioSystems Pathways for SPP1 (see all 10)

	Osteopontin Signaling
	Focal Adhesion
	TGF Beta Signaling Pathway
	Endochondral Ossification
	Toll-like receptor signaling pathway

3 Reactome Pathways for SPP1

	Integrin cell surface interactions
	Signal Transduction
	Signaling by PDGF

3 Kegg Pathways (Kegg details for SPP1):

	Focal adhesion
	ECM-receptor interaction
	Toll-like receptor signaling pathway

SPP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for SPP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for SPP1 (P10451^{2, 3} ENSP00000378517⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABCF3	Q9NUQ8²^,³	MINT-65157 I2D: score=4
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2863322 MINT-2863341 I2D: score=4 STRING: ENSP00000357292
SGTA	O43765²^,³, ENSP00000221566⁴	MINT-66220 I2D: score=5 STRING: ENSP00000221566
CTNNBL1	Q8WYA6²^,³, ENSP00000355050⁴	MINT-67203 I2D: score=5 STRING: ENSP00000355050
PDLIM7	Q9NR12²^,³, ENSP00000348099⁴	MINT-66700 I2D: score=5 STRING: ENSP00000348099

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	--	--
GO:0001649	osteoblast differentiation	IEA	--
GO:0006954	inflammatory response	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007566	embryo implantation	TAS	16720713

SPP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SPP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPP1
10/110 Novoseek chemical compound relationships for SPP1 gene (see all 110) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium oxalate	78.9	137	19581305 (5), 10461108 (5), 12706004 (4), 16104927 (4) (see all 44)
grgds	76.3	42	7522656 (6), 8972713 (4), 1421573 (2), 11787071 (1) (see all 17)
alizarin	75.8	6	15165454 (1), 15271969 (1), 20413153 (1), 15956138 (1) (see all 6)
hydroxyapatite	74.7	143	16007483 (9), 8010953 (4), 7615968 (4), 16011845 (4) (see all 58)
1,25 dihydroxy vitamin d3	60.5	12	10404392 (1), 11834737 (1), 7571189 (1), 8900396 (1) (see all 12)
lm 609	60.4	2	10726209 (1), 7522656 (1)
nimorazole	59.5	2	16198981 (2)
calcium	52.6	169	16145474 (4), 10460892 (4), 7988430 (4), 20144595 (3) (see all 91)
titanium	52	14	20155835 (2), 18983324 (2), 17437306 (2), 11173803 (1) (see all 6)
vitamin d	50	43	19246678 (2), 7708050 (1), 9556070 (1), 1665202 (1) (see all 28)

Search CenterWatch for drugs/clinical trials and news about SPP1 / OSTP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPP1 gene (5 alternative transcripts):

NM_000582.2 NM_001040058.1 NM_001040060.1 NM_001251829.1 NM_001251830.1

Unigene Cluster for SPP1:

Secreted phosphoprotein 1

Hs.313 [show with all ESTs]

Unigene Representative Sequence: NM_001251830

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000237623(uc003hra.3 uc003hrb.3 uc003hrc.3 uc003hrd.3)

ENST00000395080 ENST00000360804 ENST00000504310 ENST00000513981 ENST00000509334

ENST00000508233 ENST00000509659(uc011cde.2) ENST00000508002 ENST00000505146

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SPP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPP1
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SPP1:
		hsa-miR-181c hsa-miR-3065-5p hsa-miR-33b hsa-miR-181a hsa-miR-181d hsa-miR-33a hsa-miR-181b hsa-miR-4262

		SwitchGear 3'UTR luciferase reporter plasmid: SPP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPP1 (see all 7) OriGene shRNA RFP: SPP1 OriGene siRNA: SPP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPP1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPP1 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SPP1 (NM_001040058)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPP1
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPP1

Additional cDNA sequence:

AB019562.1 AB209987.1 AB469789.1 AF052124.1 AK057738.1 AK075463.1 AK290090.1 AK290104.1

AK295491.1 AK296035.1 AK315461.1 AY956318.1 BC007016.1 BC017387.1 BC022844.1 BC093033.1

BX648003.1 D28759.1 D28760.1 D28761.1 DQ839491.1 DQ846870.1 DQ846871.1 HQ874460.1

HQ874461.1 J04765.1 M83248.1 X13694.1

24/50 DOTS entries (see all 50):

DT.100889418 DT.99982600 DT.95324972 DT.92471676 DT.100889364 DT.454110 DT.91739764 DT.91690113

DT.92471713 DT.92410290 DT.121247185 DT.100889395 DT.100889393 DT.100889376 DT.95299295 DT.435134

DT.100889441 DT.95311246 DT.100889421 DT.92471710 DT.121247173 DT.121247212 DT.121247266 DT.100889380

24/1338 AceView cDNA sequences (see all 1338):

BI491007 BU164427 BG167131 BQ775873 AI924770 CA428029 CR610632 BG164584

AL542581 CB139553 BC007016 CA412415 BQ639810 BU736483 AF052124 BQ340439

BU158575 CR610609 CR618080 CA413769 BG142252 CR621889 BU617661 AA911756

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SPP1 (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b
SP1:									-		-						-
SP2:									-		-						-
SP3:											-						-
SP4:																	-
SP5:									-		-

ECgene alternative splicing isoforms for SPP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAGAAATT

About this image

SPP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/80 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 80)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Autopod Growth Plate

Hypertrophic Chondrocytes

Selective marker (cell-identifying gene)

Bone, Cartilage

Bone

Autopod Growth Plate

Terminal Chondrocytes

Bone, Cartilage

Bone

Autopod Periosteum

Endochondral Osteoblasts

Bone

Autopod Periosteum

Endochondral Osteocytes

Bone

Autopod Periosteum

Immature Endochondral Osteoblasts

Bone

Caudal Endochondral Bones

Endochondral Osteoblasts

Bone

Caudal Endochondral Bones

Endochondral Osteocytes

Bone

Caudal Endochondral Bones

Hypertrophic Chondrocytes

Bone, Cartilage

Bone

Caudal Endochondral Bones

Terminal Chondrocytes

Bone, Cartilage

Bone

Cervical Vertebrae

Endochondral Osteocytes

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/27 LifeMap Cells (see all 27)

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor SM22 (Embryonic Progenitor Cell)

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See SPP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPP1

SOURCE GeneReport for Unigene cluster: Hs.313

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

Tissue specificity: Bone. Found in plasma

SABiosciences Expression via Pathway-Focused PCR Arrays including SPP1 (see all 18):

Lung Cancer in human mouse rat

Extracellular Matrix & Adhesion Molecules in human mouse rat

Antiviral Response in human mouse rat

T-cell & B-cell Activation in human mouse rat

Estrogen Receptor Signaling in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SPP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPP1
		Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPP1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPP1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Spp1^{1 , 5}	secreted phosphoprotein 1^{1, 5}	73.93(n)¹ 68.05(a)¹		5 (50.68 cM)⁵ 20750¹ NM_001204201.1¹ NP_001191130.1¹ 104435118⁵
chicken (Gallus gallus)	Aves	SPP1⁶	osteopontin	27(a)	1 ↔ 1	4(47107503-47110531)
lizard (Anolis carolinensis)	Reptilia	SPP1⁶	--	29(a)	1 ↔ 1	5(45561836-45565946)

ENSEMBL Gene Tree for SPP1 (if available)
TreeFam Gene Tree for SPP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPP1
1 Inversion: 37256
Human Gene Mutation Database (HGMD): SPP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPP1

DNA2.0 Custom Variant and Variant Library Synthesis for SPP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPP1 for disorders           About GeneDecksing

OMIM gene information: 166490    OMIM disorders: --

20/232 diseases for SPP1 (see all 232):    About MalaCards

vogt-koyanagi-harada disease open-angle glaucoma atypical teratoid rhabdoid tumor relapsing-remitting multiple sclerosis

calcific tendinitis pigmented villonodular synovitis dentinogenesis imperfecta villonodular synovitis

dentin dysplasia primary open angle glaucoma dentin dysplasia, type ii osteofibrous dysplasia

neuromyelitis optica central nervous system lymphoma periventricular leukomalacia autoimmune lymphoproliferative syndrome

lichen planus allergic contact dermatitis coronary restenosis contact dermatitis

6 diseases from the University of Copenhagen DISEASES database for SPP1:

Cancer Kidney disease Osteoporosis Atherosclerosis

Calcinosis Heart disease

10/98 Novoseek disease relationships for SPP1 gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
calcification	77.6	339	10766759 (10), 15041047 (7), 19902145 (6), 15820201 (6) (see all 99)
metastasis	64.3	485	16831281 (6), 11315992 (6), 18972404 (5), 9637769 (4) (see all 99)
dentinogenesis imperfecta	63.3	2	9541230 (1), 7665163 (1)
renal stone	62.9	44	8619372 (5), 8761944 (4), 7571189 (3), 7735136 (3) (see all 17)
urinary stones	59.8	59	8325891 (4), 10929424 (4), 9365840 (3), 1575754 (2) (see all 25)
dentin dysplasia	58.1	1	9541230 (1)
osteosarcoma	56.5	28	12404059 (5), 17022822 (4), 14975209 (2), 14994076 (2) (see all 13)
tumors	54.6	841	9761120 (9), 8080043 (8), 15355566 (7), 20377868 (7) (see all 99)
lymphatic metastasis	49.3	13	16880782 (2), 17148500 (2), 16816376 (2), 17181739 (1) (see all 6)
pleural malignant mesothelioma	48.9	14	17493236 (2), 19528482 (2), 17504993 (2), 16221779 (2) (see all 8)

Genetic Association Database (GAD): SPP1
Human Genome Epidemiology (HuGE) Navigator: SPP1 (56 documents)

Export disorders for SPP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPP1 gene, integrated from 9 sources (see all 1938):
(articles sorted by number of sources associating them with SPP1)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin. (PubMed id 1575754)^{1, 2, 3, 9} Kohri K.... Kurita T. (1992)
Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism. (PubMed id 15742430)^{1, 4, 9} Xu G....Zhang J. (2005)
Expression of osteopontin in human glioma. Its correlation with the malignancy. (PubMed id 7837791)^{1, 2, 9} Saitoh Y.... Ushio Y. (1995)
A polymorphism of the osteopontin gene is related to urinary calcium stones. (PubMed id 16145474)^{1, 4, 9} Gao B....Kohri K. (2005)
Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study. (PubMed id 15744522)^{1, 4, 9} Taylor B.C....Sidney S. (2005)
Osteopontin polymorphisms and disease course in multiple sclerosis. (PubMed id 12761568)^{1, 4, 9} Caillier S....Oksenberg J.R. (2003)
Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients. (PubMed id 12620651)^{1, 4, 9} Niino M....Tashiro K. (2003)
Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. (PubMed id 1729712)^{1, 2, 9} Shiraga H.... Hoyer J.R. (1992)
Osteopontin gene polymorphisms in Spanish patients with rheumatoid arthritis. (PubMed id 15742429)^{1, 4, 9} Urcelay E....de la Concha E. (2005)
Two single-nucleotide polymorphisms in the 5' and 3' ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus. (PubMed id 15692970)^{1, 4, 9} D'Alfonso S....Momigliano-Richiardi P. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6696	HGNC: 11255	AceView: SPP1	Ensembl:ENSG00000118785	euGenes: HUgn6696
ECgene: SPP1	Kegg: 6696	H-InvDB: SPP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SPP1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Osteopontin

Intellectual Property for SPP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPP1 gene:
Search GeneIP for patents involving SPP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of SPP1

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for SPP1 (Osteopontin/OPN)		Browse Cell Culture Products
	ELISAs for SPP1 (Osteopontin/OPN)		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents for SPP1 (Osteopontin/OPN)
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for SPP1 (Osteopontin/OPN)

	OriGene Antibodies for SPP1		OriGene shRNA RFP for SPP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPP1
	OriGene Protein Over-expression Lysate for SPP1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SPP1		OriGene 3'-UTR Clone for SPP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for SPP1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SPP1		OriGene Custom Protein Services for SPP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPP1
	Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPP1

	GenScript Custom Purified and Recombinant Proteins Services for SPP1		GenScript cDNA clones with any tag delivered in your preferred vector for SPP1
	GenScript Custom Assay Services for SPP1		GenScript Custom Superior Antibodies Services for SPP1
	GenScript Custom overexpressing Cell Line Services for SPP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SPP1 promoter
	Search Chromatin IP Primers for SPP1
	RT² qPCR Primer Assay in human, mouse, rat SPP1
	GNC Network for SPP1
	SABiosciences PCR Arrays including human, mouse, rat SPP1

Search Tocris compounds for SPP1

	Proteins and Antibodies for SPP1
	cDNA Clones for SPP1
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Assays for SPP1
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SPP1 antibodies
	SPP1 proteins
	SPP1 lysates

	Antibodies for SPP1
	See all of Abcam's Antibodies, Kits and Proteins for SPP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for SPP1

SPP1 Proteins, Antibodies, CLIAs, and ELISAs

Cell Lines associated with SPP1: Osteogenic Package SK11,
Osteogenic Package SM30, PureStem 7SMOO32, NCr-fac & Meso Progenitor, PureStem SK11, NCr-fac & Meso-prx Progenitor

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPP1

	SwitchGear 3'UTR luciferase reporter plasmids for SPP1
	SwitchGear Promoter luciferase reporter plasmids for SPP1

ThermoFisher Antibodies for SPP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPP1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPP1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

SPP1 Gene

secreted phosphoprotein 1

Aliases
for SPP1 gene

Summaries
for SPP1 gene

Genomic Views
for SPP1 gene

Proteins
for SPP1 gene

Protein Domains /
Families
for SPP1 gene

Function
for SPP1 gene

Pathways & Interactions
for SPP1 gene

Drugs & Compounds
for SPP1 gene

Transcripts
for SPP1 gene

Expression
for SPP1 gene

Orthologs
for SPP1 gene

Paralogs
for SPP1 gene

Genomic Variants
for SPP1 gene

Disorders / Diseases
for SPP1 gene

Publications
for SPP1 gene

External Searches for SPP1 gene

Genome Databases showing SPP1 gene

Other Databases showing SPP1 gene

Specialized Databases showing SPP1 gene

Intellectual Property
for SPP1 gene

Products
for SPP1 gene

View Random Gene

Coronary Restenosis
Calcific tendinitis
OSTEOFIBROUS DYSPLASIA
Renal Cancer
nonmetastatic
Sclerosis
Dentinogenesis Imperfecta
aggressiveness
ADENOCARCINOMA LUNG
allergy
Bone Diseases
Intoxication
Atherosclerosis
Lymphatic Metastasis
Breast Cancer
Neovascularization
primary tumor
NSCLC
Adenocarcinoma
Neck Cancer
Cancer
NEPHROPATHY OBSTRUCTIVE
bone loss
RENAL STONE
HYPERPHOSPHATEMIA
Periodontal Diseases
Ovarian Cancer
RENAL DISEASE
Osteolysis
Nephropathy IGA
Multiple Sclerosis
Inflammation
BONE LESION
glomerulosclerosis
HNSCC
osteolytic
MYELOMA
Rheumatoid Arthritis
prostate cancer
Malignant mesothelioma
Tumors
Aortic Stenosis
Metastasis
Hyperoxaluria
Multiple Sclerosis Relapsing-Remitting
Necrosis
Carotid Atherosclerosis
Collagen fibril
neoplastic transformation
FIBROSIS IDIOPATHIC PULMONARY
Nephrotic Syndrome Minimal Change
Gastric Cancer
Autoimmune Diseases
BREAST CARCINOMA
Melanoma
Urolithiasis
atherosclerotic plaque
BONE TUMOR
NSCLC Stage I
Astrocytoma
Carcinoma
Osteoarthritis
Rhabdoid Tumor
Calcinosis
OSTEOCLASTOMA
Osteosarcoma
Osteoporosis
PLEURAL MALIGNANT MESOTHELIOMA
Calculi
metastatic cancer
HEPATOCELLULAR CARCINOMA
Calcification
Arteriosclerosis
Biliary Atresia
THYROID PAPILLARY CARCINOMA
Carcinoma Renal Cell
Nephrolithiasis
Cancer Lung
AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME
Uremia
gestational trophoblastic disease
Ascites
mesothelioma
Coronary atheroma
solid tumor
Carcinoma Squamous Cell
papillary thyroid cancer
ventricular hypertrophy
Granuloma
Lupus Nephritis
Nephrocalcinosis
Glomerulonephritis
BONE DESTRUCTION
Urinary Stones
Dentin Dysplasia
bone metastases
Renal Failure Chronic
Lupus Erythematosus Systemic

Advanced Search

Export list of displayed genes

SPP1 Gene

secreted phosphoprotein 1

Aliasesfor SPP1 gene

Summariesfor SPP1 gene

Genomic Viewsfor SPP1 gene

Proteinsfor SPP1 gene

Protein Domains /Familiesfor SPP1 gene

Functionfor SPP1 gene

Pathways & Interactionsfor SPP1 gene

Drugs & Compoundsfor SPP1 gene

Transcriptsfor SPP1 gene

Expression for SPP1 gene

Orthologsfor SPP1 gene

Paralogsfor SPP1 gene

Genomic Variantsfor SPP1 gene

Disorders / Diseasesfor SPP1 gene

Publicationsfor SPP1 gene

External Searches for SPP1 gene

Genome Databases showing SPP1 gene

Other Databases showing SPP1 gene

Specialized Databases showing SPP1 gene

Intellectual Propertyfor SPP1 gene

Productsfor SPP1 gene

View Random Gene

Aliases
for SPP1 gene

Summaries
for SPP1 gene

Genomic Views
for SPP1 gene

Proteins
for SPP1 gene

Protein Domains /
Families
for SPP1 gene

Function
for SPP1 gene

Pathways & Interactions
for SPP1 gene

Drugs & Compounds
for SPP1 gene

Transcripts
for SPP1 gene

Expression
for SPP1 gene

Orthologs
for SPP1 gene

Paralogs
for SPP1 gene

Genomic Variants
for SPP1 gene

Disorders / Diseases
for SPP1 gene

Publications
for SPP1 gene

Intellectual Property
for SPP1 gene

Products
for SPP1 gene