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SPP1 Gene

protein-coding GIFtS: 69

GC04P089115

secreted phosphoprotein 1
(Previous names: osteopontin, bone sialoprotein I )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: BNSP, OPN)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BNSP ^², ³
BSPI ^¹, ²
ETA-1 ^¹, ²
MGC110940 ^²
Nephropontin ^³
OPN ^², ³, ⁵
SPP-1 ^³
Uropontin ^³
osteopontin ^¹, ²

Descriptions
Bone sialoprotein 1 ^³
SPP1/CALPHA1 fusion ^²
Urinary stone protein ^³
bone sialoprotein I ^¹, ²
early T-lymphocyte activation 1 ^²
osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein ^²
secreted phosphoprotein 1 ^², ³
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) ^²
secreted phosphoprotein-1 (osteopontin, bone sialoprotein) ^²

External Ids
HGNC: 11255¹
Entrez Gene: 6696²
UniProtKB: P10451³
Ensembl: ENSG00000118785⁷

Search outside databases for aliases for SPP1 gene

Previous GC identifers: GC04P089054 GC04P089198 GC04P089355 GC04P089253

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

Function: Acts as a cytokine involved in enhancing production of interferon-gamma and

interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that

leads to type I immunity (By similarity)

Gene Wiki entry for SPP1 (Osteopontin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the SPP1 gene

Entrez Gene cytogenetic band: 4q21-q25 Ensembl cytogenetic band: 4q22.1 HGNC cytogenetic band: 4q22.1

SPP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P089115: (about GC identifiers)

Start:	89,115,826 bp from pter
End:	89,123,587 bp from pter
Size:	7,762 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451 (See protein sequence)

Recommended Name: Osteopontin precursor

Size: 314 amino acids; 35423 Da

Subunit: Ligand for integrin alpha-V/beta-3

Subcellular location: Secreted

PDB structure from and Proteopedia :

3CXD (3D)

3DSF (3D)

Secondary accessions: Q15681 Q15682 Q15683 Q8NBK2 Q96IZ1

Alternative splicing: 4 isoforms: P10451-1 P10451-2 P10451-3 P10451-4

Post-translational modifications:

Extensively phosphorylated on clustered serine residues¹

N- and O-glycosylated¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_000573.1 NP_001035147.1 NP_001035149.1

ENSEMBL proteins:

ENSP00000354042 ENSP00000378517 ENSP00000237623 ENSP00000351971

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant SPP1 Protein
	Sigma-Aldrich Proteins for SPP1
	R&D Systems Recombinant & Natural Proteins for SPP1 (Osteopontin)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Osteopontin)
	Human Recombinant Proteins from Abnova (SPP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005615	extracellular space	IEA	--

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Antibodies for SPP1:

	Invitrogen Antibodies for SPP1
	Millipore Mono- and Polyclonal Antibodies for the study of SPP1
	Sigma-Aldrich Antibodies for SPP1
	R&D Systems Antibodies for SPP1 (Osteopontin)
	Antibodies from Abcam (Osteopontin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (SPP1)
	Novus Biologicals Antibodies for SPP1

Assays for SPP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for SPP1 (Osteopontin) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P10451

ProtoNet protein and cluster: P10451

1 Blocks protein family: IPB002038 Osteopontin

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

Similarity: Belongs to the osteopontin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC017387

Applied Biosystems Silencer® siRNAs for SPP1

Sigma-Aldrich siRNA for SPP1

Sigma-Aldrich shRNA Panels and shRNA for SPP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for SPP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000582
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000582
untagged cDNA clones in CMV expression vector (see all 5): BC017387

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC017387

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

Function: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized

matrix. Probably important to cell-matrix interaction

Function: Acts as a cytokine involved in enhancing production of interferon-gamma and

interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that

leads to type I immunity (By similarity)

Genatlas biochemistry entry for SPP1:

secreted phosphoprotein 1 (osteopontin),regulated by CBFA1 and ETS1 in the skeletal tissue

8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Spp1):

	hematopoietic system	homeostasis/metabolism	immune system	life span-post-weaning/aging
nervous system	reproductive system	skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005125	cytokine activity	IEA	--
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for SPP1 (Your Favorite Gene powered by Ingenuity)

VDR/RXR Activation
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency

GeneDecks SPP1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for SPP1

5/186 Interacting proteins for SPP1 (P10451² ENSP00000237623³) via UniProtKB, MINT, and/or STRING (see all 186 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBQLN4	Q9NRR5²	MINT-2863322 MINT-2863341
CTNNBL1	Q8WYA6²	MINT-67203
PDLIM7	Q9NR12²	MINT-66700
SGTA	O43765²	MINT-66220
ITGAV	ENSP00000364042³	STRING (score=.993)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001503	ossification	IEA	--
GO:0007155	cell adhesion	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for SPP1
10/47 Novoseek chemical compound relationships for SPP1 gene (see all 47 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium oxalate	79.12	111	10461108 (5), 12706004 (4), 16104927 (4), 9453017 (3) (see all 40)
alizarin	76.48	5	15165454 (1), 15271969 (1), 15956138 (1), 17868116 (1) (see all 5)
hydroxyapatite	73.66	112	16007483 (9), 8010953 (4), 16011845 (4), 7615968 (4) (see all 49)
1,25 dihydroxy vitamin d3	62.41	12	10404392 (1), 11834737 (1), 7571189 (1), 8900396 (1) (see all 12)
lm 609	62.28	2	10726209 (1), 7522656 (1)
grgdsp	51.91	8	9639398 (3), 8293561 (1), 16960829 (1)
calcium	50.73	139	16145474 (4), 10460892 (4), 7988430 (4), 1447223 (3) (see all 76)
gamma-carboxyglutamic acid	49.20	2	9516456 (1), 17095733 (1)
ptms	44.29	4	15869464 (1), 11792563 (1), 18072945 (1)
titanium	44.17	12	18983324 (2), 17437306 (2), 11173803 (1), 18688796 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (SPP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (SPP1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): BC017387

Sigma-Aldrich siRNA for SPP1

Sigma-Aldrich shRNA Panels and shRNA for SPP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000582 NM_001040058 NM_001040060

REFSEQ mRNAs for SPP1 gene (3 alternative transcripts):

NM_000582.2 NM_001040058.1 NM_001040060.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000582 NM_001040058 NM_001040060

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_000582
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_000582
                                 untagged cDNA clones in CMV expression vector (see all 5): BC017387

Additional cDNA sequence:

AB019562.1 AB209987.1 AF052124.1 AK057738.1 AK075463.1 AK290090.1 AK290104.1 AK295491.1

AK296035.1 AK315461.1 AY956318.1 BC007016.1 BC017387.1 BC022844.1 BC093033.1 BX648003.1

CR590548.1 CR590765.1 CR591447.1 CR591466.1 CR591781.1 CR591902.1 CR592228.1 CR592500.1

CR593010.1 CR593792.1 CR593987.1 CR594254.1 CR594618.1 CR594667.1 CR594911.1 CR594979.1

CR595305.1 CR596445.1 CR596475.1 CR597399.1 CR597759.1 CR599125.1 CR600336.1 CR600682.1

CR600714.1 CR600744.1 CR601143.1 CR601537.1 CR602328.1 CR602900.1 CR603218.1 CR603247.1

CR604739.1 CR605902.1 CR606646.1 CR607920.1 CR608403.1 CR608709.1 CR608820.1 CR609665.1

CR610220.1 CR610252.1 CR610312.1 CR610546.1 CR610609.1 CR610632.1 CR610677.1 CR611180.1

CR612096.1 CR612661.1 CR612712.1 CR613043.1 CR613121.1 CR613156.1 CR613454.1 CR613613.1

CR614122.1 CR614125.1 CR614191.1 CR615073.1 CR615383.1 CR615698.1 CR616615.1 CR616812.1

CR617116.1 CR617515.1 CR618080.1 CR618220.1 CR618369.1 CR618594.1 CR618956.1 CR619414.1

CR619578.1 CR619881.1 CR620974.1 CR621274.1 CR621360.1 CR621428.1 CR621889.1 CR622075.1

CR623036.1 CR624029.1 CR624157.1 CR624176.1 CR624416.1 CR624537.1 CR624945.1 CR625643.1

CR625710.1 CR625747.1 CR626471.1 CR626718.1 D28759.1 D28760.1 D28761.1 DQ839491.1

DQ846870.1 DQ846871.1 J04765.1 M83248.1 X13694.1

24/50 DOTS entries (see all 50 ):

DT.100889418 DT.99982600 DT.92471676 DT.95324972 DT.454110 DT.100889364 DT.91739764 DT.91690113

DT.92471713 DT.92410290 DT.121247185 DT.100889395 DT.100889376 DT.100889393 DT.95299295 DT.435134

DT.100889441 DT.95311246 DT.100889421 DT.92471710 DT.121247173 DT.121247212 DT.121247266 DT.100889380

24/1338 AceView cDNA sequences (see all 1338 ):

CR624537 BX396687 BP348139 CR601537 BG170652 CR594979 CR600714 CR618220

BG164441 BX458441 BU619656 AA379957 BG164524 AI924770 CR624416 CR603218

BX398560 AA345409 BQ212304 AA232574 AI086391 CR612712 BQ638427 AA357374

highest scoring ESTs for SPP1:

AF052124 J04765 AA021512 AA101270 AA171630 AA232626 AA242891 AA252035 AA300291 AA345409

Unigene Cluster for SPP1:

Secreted phosphoprotein 1

Hs.313 [show with all ESTs]

Unigene Representative Sequence: BF698898

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SPP1 (see all 6 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	·	8c	^	9a	·	9b
SP1:									-		-						-
SP2:									-		-						-
SP3:											-						-
SP4:																	-
SP5:									-		-

About this scheme

ECgene alternative splicing isoforms for SPP1

4 Ensembl transcripts including schematic representations:

ENST00000360804 ENST00000395080 ENST00000237623 ENST00000359072

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

SPP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for SPP1

¹ / ² / ³

5 probe-sets matching SPP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
2092_s_at²^{, 3}	U95-A	1	1.00	1.00	0.99	0.84	J04765	1.00	1.00	1.00	1
74815_at²^{, 3}	U95-D	1	1.00	1.00	1.00	1.24	AI864016	0.60	1.00	0.82	1
34342_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	0.93	AF052124	1.00	1.00	1.00	1
209875_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M83248	0.80	1.00	0.91	1
209875_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks SPP1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATAGAAATT

SOURCE GeneReport for Unigene cluster: Hs.313
Expression variation in blood from EXPOLDB for SPP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for SPP1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	SPP1¹	--	secreted phosphoprotein 1	77.82(n) 63.24(a)	478471 XM_535649.2 XP_535649.2
chimpanzee (Pan troglodytes)	SPP1¹	--	secreted phosphoprotein 1	98.95(n) 97.56(a)	461366 XM_001159723.1 XP_001159723.1
cow (Bos taurus)	SPP1¹	--	secreted phosphoprotein 1	78.88(n) 68.92(a)	281499 NM_174187.2 NP_776612.1
rat (Rattus norvegicus)	Spp1¹	--	secreted phosphoprotein 1	74.42(n) 67.16(a)	25353 NM_012881.1 NP_037013.1
mouse (Mus musculus)	Spp1^{1, 5}	5 (56.00 cM)⁵	secreted phosphoprotein 1^{1, 5}	73.93(n)¹ 68.05(a)¹	20750¹ NM_009263.1¹ NP_033289.1¹ AA960535⁵ AF515708⁵ (see all 39)

About this table Species with no ortholog for SPP1

ENSEMBL Gene Tree for SPP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/105 NCBI SNPs in SPP1 are shown (see all 105 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 73)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs9138^1,2	A,C,F,H,O	89123366(+)	`GTAGAA/CGCAAA`	3	--	ut3¹		15	MN NS NA EU EA WA	1082
--	rs2853744^1,2	A,C,F,H	89115272(+)	`ATCCTG/TCTCTC`	3	--	ng5¹		4	EU EA WA	412
	rs1126772^1,2	A,C,F,H	89123210(+)	`TAACTA/GATGTG`	3	--	ut3¹		14	MN EA NA EU WA	1246
	rs11730582^1,2	A,C,F	89115445(+)	`AAGTTT/CTCTGA`	3	--	ng5¹		5	NA EA	386
	rs7435825^1,2	C,F,H	89122798(+)	`GGACAG/ATTATG`	3	N/S	mis¹		17	NS NA EU EA WA	1136
	rs4660^1,2	C,F,H	89123029(+)	`ATTTCG/ATATTT`	3	H/R	mis¹ ese³		15	MN NA EU EA WA	1466
	rs2728127^1,2	A,C,F	89114139(+)	`TTTTCA/GGACTT`	3	--	ng5¹		4	EA NA	216
--	rs35335469^1,2	C,F	89123709(+)	`TAATT-/ATCATATC`	3	--	ng3¹		1	NA	42
--	rs1126893^1,2	F,H	89123418(+)	`ATGTCA/CCTATA`	3	--	ut3¹ ese³		5	MN EU EA WA	586
--	rs41351345^1,2	F	89115458(+)	`TCCTTG/TCAGGC`	3	--	ng5¹		1	NA	36

About this table

HapMap Linkage Disequilibrium images for SPP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 166490

UniProtKB/Swiss-Prot: OSTP_HUMAN, P10451

This protein plays a principal role in urinary stone formation as the stone matrix

10/94 Novoseek disease relationships for SPP1 gene (see all 94 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcification	75.93	276	10766759 (10), 15041047 (7), 15820201 (6), 9099263 (5) (see all 99)
dentinogenesis imperfecta	65.34	2	9541230 (1), 7665163 (1)
renal stone	63.34	38	8619372 (5), 8761944 (4), 7571189 (3), 7735136 (3) (see all 15)
metastasis	62.47	393	16831281 (6), 11315992 (6), 18972404 (5), 9637769 (4) (see all 99)
urinary stones	62.30	59	8325891 (4), 10929424 (4), 9365840 (3), 1575754 (2) (see all 25)
dentin dysplasia	60.27	1	9541230 (1)
osteosarcoma	57.41	28	12404059 (5), 17022822 (4), 14975209 (2), 14994076 (2) (see all 13)
tumors	52.31	712	9761120 (9), 8080043 (8), 15355566 (7), 15501463 (6) (see all 99)
lymphatic metastasis	50.67	12	16880782 (2), 17148500 (2), 16816376 (2), 17181739 (1) (see all 5)
atherosclerotic plaque	50.10	36	7918316 (4), 8293561 (2), 8408622 (2), 17128682 (1) (see all 17)

About this table

Human Gene Mutation Database: SPP1
Genetic Association Database: SPP1
Human Genome Epidemiology Navigator: SPP1 (34 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1428 PubMed articles for SPP1 gene (see all 1428 ):

Molecular cloning and sequencing of cDNA encoding urinary stone protein, which is identical to osteopontin. (PubMed id 1575754)^{1, 2, 3, 4} Kohri K.... Kurita T. (1992)
Overexpression of osteopontin in rheumatoid synovial mononuclear cells is associated with joint inflammation, not with genetic polymorphism. (PubMed id 15742430)^{1, 3, 6} Xu G....Zhang J. (2005)
Expression of osteopontin in human glioma. Its correlation with the malignancy. (PubMed id 7837791)^{1, 3, 4} Saitoh Y.... Ushio Y. (1995)
A polymorphism of the osteopontin gene is related to urinary calcium stones. (PubMed id 16145474)^{1, 3, 6} Gao B....Kohri K. (2005)
Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study. (PubMed id 15744522)^{1, 3, 6} Taylor B.C....Sidney S. (2005)
Osteopontin polymorphisms and disease course in multiple sclerosis. (PubMed id 12761568)^{1, 3, 6} Caillier S....Oksenberg J.R. (2003)
Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa Bone Development Study. (PubMed id 12879219)^{1, 3, 6} Willing M.C....Levy S.M. (2003)
Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients. (PubMed id 12620651)^{1, 3, 6} Niino M....Tashiro K. (2003)
Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. (PubMed id 1729712)^{1, 3, 4} Shiraga H.... Hoyer J.R. (1992)
Osteopontin gene polymorphisms in Spanish patients with rheumatoid arthritis. (PubMed id 15742429)^{1, 3, 6} Urcelay E....de la Concha E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6696	HGNC: 11255	AceView: SPP1	Ensembl:ENSG00000118785	euGenes: HUgn6696
ECgene: SPP1	H-InvDB: SPP1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for SPP1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for SPP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for SPP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for SPP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for SPP1		Antibodies for SPP1
	Explore super-pooled esiRNAs		Proteins for SPP1
	Lentivirus-delivered shRNAs for SPP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (SPP1)
	Antibodies (SPP1)
	Chimera RNAi (SPP1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Osteopontin)
	Antibodies (Osteopontin)

Search OriGene for SPP1

Search Tocris compounds for SPP1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for SPP1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
SPP1 Gene at Home site.
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SPP1 Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for SPP1

Summaries
for SPP1

Genomic Location
for SPP1

Proteins
for SPP1

Protein Domains/
Families
for SPP1

Gene Function
for SPP1

Pathways & Interactions
for SPP1

Drugs & Compounds
for SPP1

Transcripts
for SPP1

Expression
for SPP1

Orthologs
for SPP1

Paralogs
for SPP1

SNPs/Variants
for SPP1

Disorders & Mutations
for SPP1

Medical News
for SPP1

Publications
for SPP1

Search for SPP1

Genome Databases showing SPP1

Other Databases showing SPP1

Specialized Databases showing SPP1

Licensable Technologies
for SPP1

Services
for SPP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

SPP1 Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor SPP1

Summariesfor SPP1

Genomic Locationfor SPP1

Proteinsfor SPP1

Protein Domains/Familiesfor SPP1

Gene Functionfor SPP1

Pathways & Interactionsfor SPP1

Drugs & Compoundsfor SPP1

Transcriptsfor SPP1

Expression for SPP1

Orthologsfor SPP1

Paralogsfor SPP1

SNPs/Variantsfor SPP1

Disorders & Mutationsfor SPP1

Medical Newsfor SPP1

Publicationsfor SPP1

Search for SPP1

Genome Databases showing SPP1

Other Databases showing SPP1

Specialized Databases showing SPP1

Licensable Technologiesfor SPP1

Servicesfor SPP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for SPP1

Summaries
for SPP1

Genomic Location
for SPP1

Proteins
for SPP1

Protein Domains/
Families
for SPP1

Gene Function
for SPP1

Pathways & Interactions
for SPP1

Drugs & Compounds
for SPP1

Transcripts
for SPP1

Expression
for SPP1

Orthologs
for SPP1

Paralogs
for SPP1

SNPs/Variants
for SPP1

Disorders & Mutations
for SPP1

Medical News
for SPP1

Publications
for SPP1

Licensable Technologies
for SPP1

Services
for SPP1