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Aliases for SPOUT1 Gene

Aliases for SPOUT1 Gene

  • SPOUT Domain Containing Methyltransferase 1 2 3 5
  • Centromere Protein 32 2 3 4
  • Kinetochore-Associated Protein 3 4
  • C9orf114 3 4
  • CENP-32 3 4
  • SPOUT Domain-Containing Methyltransferase 1 4
  • Chromosome 9 Open Reading Frame 114 2
  • Putative Methyltransferase C9orf114 3
  • EC 2.1.1.- 4
  • HSPC109 3
  • CENP32 3

External Ids for SPOUT1 Gene

Previous HGNC Symbols for SPOUT1 Gene

  • C9orf114

Summaries for SPOUT1 Gene

GeneCards Summary for SPOUT1 Gene

SPOUT1 (SPOUT Domain Containing Methyltransferase 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SPOUT1 Gene

  • Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325).

Additional gene information for SPOUT1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOUT1 Gene

Genomics for SPOUT1 Gene

Regulatory Elements for SPOUT1 Gene

Enhancers for SPOUT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H128828 1.1 ENCODE 69.8 +0.4 361 1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 FOS DEK SPOUT1 CIZ1 GOLGA2 NUP188 ODF2 PKN3 LOC101929314 SLC25A25-AS1 TOR1B ENSG00000272696
GH09H128837 1 ENCODE 65.4 -8.5 -8521 1 FOXA2 ZNF493 ZFP64 ARID4B GLIS2 ZNF202 SP5 ZC3H11A REST PPARG NUP188 SPOUT1 ODF2 CIZ1 GOLGA2 URM1 GLE1 LOC101929314 NAIF1 SWI5
GH09H129457 2 FANTOM5 Ensembl ENCODE dbSUPER 31.3 -630.0 -630001 4 HDGF FOXA2 ARID4B SIN3A YBX1 DMAP1 YY1 ZNF766 ZNF143 FOS LOC101929314 SPOUT1 LOC101929270 NTMT1 C9orf50 NUP188 LINC00963 USP20 C9orf106 ASB6
GH09H129605 1.8 FANTOM5 ENCODE dbSUPER 29.2 -779.0 -779036 5 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MCM3 ZFP41 SSRP1 NUP188 LOC101929314 FUBP3 SPOUT1 PKN3 C9orf50 UBE2V1P4 NCS1 MIGA2 USP20
GH09H129623 1.7 FANTOM5 ENCODE dbSUPER 30.2 -796.9 -796878 6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DEK NUP188 SPOUT1 FUBP3 PKN3 PRRX2 TOR1B ENSG00000234055 LOC101929314 NTMT1 C9orf50
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPOUT1 on UCSC Golden Path with GeneCards custom track

Promoters for SPOUT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241910 147 1001 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 FOS

Genomic Location for SPOUT1 Gene

Chromosome:
9
Start:
128,819,651 bp from pter
End:
128,829,847 bp from pter
Size:
10,197 bases
Orientation:
Minus strand

Genomic View for SPOUT1 Gene

Genes around SPOUT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOUT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOUT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOUT1 Gene

Proteins for SPOUT1 Gene

  • Protein details for SPOUT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T280-CI114_HUMAN
    Recommended name:
    Putative methyltransferase C9orf114
    Protein Accession:
    Q5T280
    Secondary Accessions:
    • Q0D2P6
    • Q6P469
    • Q6PGP9
    • Q6PIJ1
    • Q6PJV9

    Protein attributes for SPOUT1 Gene

    Size:
    376 amino acids
    Molecular mass:
    42009 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Depletion with RNAi causes a significant accumulation of cells in later prometaphase with misaligned chromosomes.

    Three dimensional structures from OCA and Proteopedia for SPOUT1 Gene

neXtProt entry for SPOUT1 Gene

Post-translational modifications for SPOUT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPOUT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPOUT1 Gene

Domains & Families for SPOUT1 Gene

Gene Families for SPOUT1 Gene

Suggested Antigen Peptide Sequences for SPOUT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T280

UniProtKB/Swiss-Prot:

CI114_HUMAN :
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily.
Family:
  • Belongs to the class IV-like SAM-binding methyltransferase superfamily.
genes like me logo Genes that share domains with SPOUT1: view

Function for SPOUT1 Gene

Molecular function for SPOUT1 Gene

UniProtKB/Swiss-Prot Function:
Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:20813266, PubMed:25657325). Also involved in chromosome alignment (PubMed:20813266). May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis (PubMed:25657325).

Enzyme Numbers (IUBMB) for SPOUT1 Gene

Phenotypes From GWAS Catalog for SPOUT1 Gene

Gene Ontology (GO) - Molecular Function for SPOUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0035198 miRNA binding IDA 28431233
genes like me logo Genes that share ontologies with SPOUT1: view
genes like me logo Genes that share phenotypes with SPOUT1: view

Animal Models for SPOUT1 Gene

MGI Knock Outs for SPOUT1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPOUT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPOUT1 Gene

Localization for SPOUT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOUT1 Gene

Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with the outer kinetochore. {ECO:0000269 PubMed:20813266}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOUT1 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPOUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA,IEA 25657325
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005575 cellular_component ND --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SPOUT1: view

Pathways & Interactions for SPOUT1 Gene

SuperPathways for SPOUT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SPOUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008150 biological_process ND --
GO:0010608 posttranscriptional regulation of gene expression IMP 28431233
GO:0032259 methylation IEA --
GO:0035196 production of miRNAs involved in gene silencing by miRNA IMP 28431233
genes like me logo Genes that share ontologies with SPOUT1: view

No data available for Pathways by source and SIGNOR curated interactions for SPOUT1 Gene

Drugs & Compounds for SPOUT1 Gene

No Compound Related Data Available

Transcripts for SPOUT1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPOUT1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPOUT1 Gene

No ASD Table

Relevant External Links for SPOUT1 Gene

GeneLoc Exon Structure for
SPOUT1
ECgene alternative splicing isoforms for
SPOUT1

Expression for SPOUT1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPOUT1 Gene:

SPOUT1

Evidence on tissue expression from TISSUES for SPOUT1 Gene

  • Nervous system(4.3)
  • Blood(4.1)
  • Eye(4)
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOUT1 Gene

Orthologs for SPOUT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPOUT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf114 33
  • 99.38 (n)
C9orf114 34
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9orf114 34
  • 93 (a)
OneToOne
C9H9orf114 33
  • 88.92 (n)
cow
(Bos Taurus)
Mammalia C9orf114 34
  • 93 (a)
OneToOne
C11H9orf114 33
  • 88.59 (n)
mouse
(Mus musculus)
Mammalia D2Wsu81e 34 33
  • 85.65 (n)
OneToOne
Spout1 16
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf114 34
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C9orf114 34
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9orf114 33
  • 72.33 (n)
C17H9ORF114 34
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf114 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf114 33
  • 67.78 (n)
Str.1277 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.26356 33
zebrafish
(Danio rerio)
Actinopterygii zgc:101748 33
  • 69.25 (n)
C21H9orf114 34
  • 65 (a)
OneToOne
sbcb90 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007570 33
  • 58.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12128 33 34
  • 56.12 (n)
worm
(Caenorhabditis elegans)
Secernentea B0361.6 33 34
  • 48.74 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 22 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
-- 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19300 33
  • 51.01 (n)
rice
(Oryza sativa)
Liliopsida Os04g0244500 33
  • 54.07 (n)
Os.9692 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU00597 33
  • 50.63 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5582 33
Species where no ortholog for SPOUT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOUT1 Gene

ENSEMBL:
Gene Tree for SPOUT1 (if available)
TreeFam:
Gene Tree for SPOUT1 (if available)

Paralogs for SPOUT1 Gene

No data available for Paralogs for SPOUT1 Gene

Variants for SPOUT1 Gene

Sequence variations from dbSNP and Humsavar for SPOUT1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs864309587 Benign 128,822,605(+) GCAGT(-/AAGT)GAGGG reference, utr-variant-3-prime, frameshift-variant
rs1000000084 -- 128,830,830(+) TATTT(C/T)TAGTA intron-variant, upstream-variant-2KB
rs1000377291 -- 128,819,721(+) ACAGT(A/C)ATGTA intron-variant, utr-variant-3-prime
rs1000456416 -- 128,830,467(+) CAGGA(A/G)CGTGC intron-variant, upstream-variant-2KB
rs1000742076 -- 128,819,925(+) GGCTG(C/T)TGTGG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPOUT1 Gene

Variant ID Type Subtype PubMed ID
nsv521120 CNV loss 19592680
nsv615411 CNV loss 21841781
nsv615412 CNV loss 21841781
nsv6724 CNV insertion 18451855

Variation tolerance for SPOUT1 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.63; 93.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPOUT1 Gene

Human Gene Mutation Database (HGMD)
SPOUT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPOUT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOUT1 Gene

Disorders for SPOUT1 Gene

Relevant External Links for SPOUT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPOUT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPOUT1

No disorders were found for SPOUT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPOUT1 Gene

Publications for SPOUT1 Gene

  1. CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly. (PMID: 25657325) Ohta S … Earnshaw WC (Molecular biology of the cell 2015) 2 3 4 60
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S … Rappsilber J (Cell 2010) 2 3 4 60
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for SPOUT1 Gene

Sources for SPOUT1 Gene

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