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SPOPL Gene

protein-coding   GIFtS: 46
GCID: GC02P139259

Speckle-Type POZ Protein-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Speckle-Type POZ Protein-Like1 2
HIB Homolog 21 2 3
Roadkill Homolog 21 2 3
BTBD332

External Ids:    HGNC: 279341   Entrez Gene: 3397452   Ensembl: ENSG000001442287   UniProtKB: Q6IQ163   

Export aliases for SPOPL gene to outside databases

Previous GC identifers: GC02P138977 GC02P131251


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPOPL Gene:
SPOPL (speckle-type POZ protein-like) is a protein-coding gene. An important paralog of this gene is SPOP.

UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16
Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency.
Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the
heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May
function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase
complexes that contain SPOP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPOPL gene promoter:
         POU2F1   FOXO4   POU2F1a   FOXD1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPOPL promoter sequence
   Search Chromatin IP Primers for SPOPL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPOPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22.1   Ensembl cytogenetic band:  2q22.1   HGNC cytogenetic band: 2q22.1

SPOPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOPL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P139259:  view genomic region     (about GC identifiers)

Start:
139,259,350 bp from pter      End:
139,331,117 bp from pter
Size:
71,768 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16 (See protein sequence)
Recommended Name: Speckle-type POZ protein-like  
Size: 392 amino acids; 44647 Da
Subunit: Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein
ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3
and H2AFY

Explore the universe of human proteins at neXtProt for SPOPL: NX_Q6IQ16

Explore proteomics data for SPOPL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPOPL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001664.1  
    ENSEMBL proteins: 
     ENSP00000280098   ENSP00000410201   ENSP00000396006  

    SPOPL Human Recombinant Protein Products:

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    Novus Biologicals SPOPL Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPOPL

     
    Search eBioscience for Proteins for SPOPL 

     
    antibodies-online proteins for SPOPL (2 products) 

     
    antibodies-online peptides for SPOPL

    SPOPL Antibody Products:

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    Novus Biologicals SPOPL Antibodies
    Abcam antibodies for SPOPL
    Cloud-Clone Corp. Antibodies for SPOPL
    Search ThermoFisher Antibodies for SPOPL
    antibodies-online antibodies for SPOPL (17 products) 

    SPOPL Assay Products:

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    Cloud-Clone Corp. ELISAs for SPOPL
    Cloud-Clone Corp. CLIAs for SPOPL
    Search eBioscience for ELISAs for SPOPL 
    antibodies-online kits for SPOPL (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BTBD: BTB/POZ domain containing

    5 InterPro protein domains:
     IPR008974 TRAF-like
     IPR002083 MATH
     IPR011333 BTB/POZ_fold
     IPR013069 BTB_POZ
     IPR000210 BTB/POZ-like

    Graphical View of Domain Structure for InterPro Entry Q6IQ16

    ProtoNet protein and cluster: Q6IQ16

    1 Blocks protein domain: IPB002083 Meprin/TRAF-like MATH

    UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16
    Similarity: Belongs to the Tdpoz family
    Similarity: Contains 1 BTB (POZ) domain
    Similarity: Contains 1 MATH domain


    Find genes that share domains with SPOPL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPOPL_HUMAN, Q6IQ16
    Function: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates
    the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency.
    Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the
    heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May
    function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase
    complexes that contain SPOP

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with SPOPL           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for SPOPL:
     G0/1 arrest  Increased G1 DNA content  Increased cell number in G1, s  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SPOPL

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPOPL:
    hsa-mir-93-5p (MIRT027973), hsa-mir-324-5p (MIRT043207), hsa-mir-130b-3p (MIRT020138)

    Block miRNA regulation of human, mouse, rat SPOPL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPOPL (see all 131):
    hsa-miR-193a-3p hsa-miR-520f hsa-miR-631 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-298 hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: SPOPL (NM_001001664)
    Sino Biological Human cDNA Clone for SPOPL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOPL

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOPL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPOPL_HUMAN, Q6IQ16: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0031463Cul3-RING ubiquitin ligase complex IDA--

    Find genes that share ontologies with SPOPL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPOPL
    Interactions:

        Search GeneGlobe Interaction Network for SPOPL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for SPOPL (ENSP000002800984) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDX1ENSP000002316564STRING: ENSP00000231656
    EIF1ADENSP000003091754STRING: ENSP00000309175
    SUMO1ENSP000003760764STRING: ENSP00000376076
    GSTA4ENSP000003599984STRING: ENSP00000359998
    GLI2ENSP000003545864STRING: ENSP00000354586
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0031397negative regulation of protein ubiquitination IMP--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IMP--

    Find genes that share ontologies with SPOPL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPOPL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPOPL gene: 
    NM_001001664.2  

    Unigene Cluster for SPOPL:

    Speckle-type POZ protein-like
    Hs.333297  [show with all ESTs]
    Unigene Representative Sequence: NM_001001664
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280098(uc002tvh.3) ENST00000430968 ENST00000420679 ENST00000467775

    miRNA
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    Block miRNA regulation of human, mouse, rat SPOPL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPOPL (see all 131):
    hsa-miR-193a-3p hsa-miR-520f hsa-miR-631 hsa-miR-106a hsa-miR-128 hsa-miR-519a hsa-miR-298 hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPOPL
    Clone
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    OriGene clones in human, mouse for SPOPL (see all 8)
    OriGene ORF clones in mouse, rat for SPOPL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPOPL (NM_001001664)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOPL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOPL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPOPL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPOPL
      QuantiTect SYBR Green Assays in human, mouse, rat SPOPL
      QuantiFast Probe-based Assays in human, mouse, rat SPOPL

    Additional mRNA sequence: 

    AK094583.1 AK293850.1 BC071613.1 BX538143.1 

    7 DOTS entries:

    DT.99975092  DT.95295989  DT.410661  DT.86841653  DT.97824745  DT.95151247  DT.95362195 

    Selected AceView cDNA sequences (see all 141):

    AL700259 AA199609 AL597083 AL700478 AI093132 BF516590 AI367576 CA395342 
    AA279289 AA236924 AL597084 CK819602 AW304714 H78481 AK094583 AA737682 
    AA669111 BM831350 AA586331 BM785974 BF034206 AA586326 BE645523 CB145288 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPOPL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATCTTGTTG
    SPOPL Expression
    About this image

    SPOPL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPOPL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333297
        Custom PCR Arrays for SPOPL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOPL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPOPL gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spopl1 , 5 speckle-type POZ protein-like1, 5 92.52(n)1
    96.43(a)1
      2 (15.48 cM)5
    768571  NM_029773.21  NP_084049.21 
     235062205 
    chicken
    (Gallus gallus)
    Aves SPOPL1 speckle-type POZ protein-like 89.54(n)
    95.41(a)
      424299  XM_422144.4  XP_422144.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPOPL6
    speckle-type POZ protein-like
    93(a)
    1 ↔ 1
    1(98452786-98500005)
    zebrafish
    (Danio rerio)
    Actinopterygii spopla1 speckle-type POZ protein-like a 77.98(n)
    91.07(a)
      541318  NM_001013447.1  NP_001013465.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rdx6
    roadkill
    35(a)
    1 → many
    3R(9793674-9857777)
    worm
    (Caenorhabditis elegans)
    Secernentea bath-436
    Protein BATH-43, isoform a
    52(a)
    1 → many
    III(10090862-10098081) WBGene00011815
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons BPM11 BPM1 44.63(n)
    35.2(a)
      832018  NM_121905.2  NP_197401.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g06553001 Os07g0655300 44.24(n)
    34.55(a)
      4344139  NM_001067030.1  NP_001060495.1 


    ENSEMBL Gene Tree for SPOPL (if available)
    TreeFam Gene Tree for SPOPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPOPL gene
    SPOP2  KBTBD42  
    2 SIMAP similar genes for SPOPL using alignment to 3 protein entries:     SPOPL_HUMAN (see all proteins):
    SPOP    BTBD3

    Find genes that share paralogs with SPOPL           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for SPOPL
    PGOHUM00000245571 PGOHUM00000245578 PGOHUM00000245949


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPOPL (see all 1490)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1131047451,2
    F--139257376(+) GCTGGC/TGTTTG 1 -- us2k12Minor allele frequency- T:0.50CSA 4
    rs1813739631,2
    --139257474(+) ACTTTG/TGGAGT 1 -- us2k10--------
    rs1446845681,2
    --139257569(+) GAAAAC/TCTTTG 1 -- us2k10--------
    rs1151823211,2
    C,F--139257586(+) ATTTTG/ATCTTA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1466841841,2
    --139257665(+) TGGGAC/GGCAGA 1 -- us2k10--------
    rs757002171,2
    C,F--139257956(+) GCCTGC/TCCAGT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1909514831,2
    --139258054(+) TTTTAA/GAGAGG 1 -- us2k10--------
    rs1403535721,2
    --139258173(+) AGCAAG/TGAGAA 1 -- us2k10--------
    rs607348581,2
    C,F--139258245(+) GGTGGG/CAGGAT 1 -- us2k12Minor allele frequency- C:0.05WA 120
    rs1823958381,2
    --139258300(+) GACCTA/CGTCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPOPL (139259350 - 139331117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPOPL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv875159CNV Gain21882294
    nsv834390CNV Gain17160897
    nsv7329OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPOPL
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with SPOPL           About GenesLikeMe

    Genetic Association Database (GAD): SPOPL

    Export disorders for SPOPL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPOPL gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SPOPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. (PubMed id 16651542)1, 2 Kent D.... Hooper J.E. (Development 2006)
    2. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. (PubMed id 16740475)1, 2 Zhang Q.... Jiang J. (Dev. Cell 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. (PubMed id 23241943)1 Clark S.L....van den Oord E.J. (Pharmacogenet. Genomics 2013)
    5. Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. (PubMed id 22632832)2 Errington W.J.... Prive G.G. (Structure 2012)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339745 HGNC: 27934 AceView: LOC339745 Ensembl:ENSG00000144228 euGenes: HUgn339745
    ECgene: SPOPL H-InvDB: SPOPL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SPOPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SPOPL gene:
    Search GeneIP for patents involving SPOPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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