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Aliases for SPOPL Gene

Aliases for SPOPL Gene

  • Speckle Type BTB/POZ Protein Like 2 3
  • Roadkill Homolog 2 2 3 4
  • HIB Homolog 2 2 3 4
  • Speckle Type POZ Protein Like 3 5
  • Speckle-Type POZ Protein-Like 2
  • BTBD33 3

External Ids for SPOPL Gene

Previous GeneCards Identifiers for SPOPL Gene

  • GC02P138977
  • GC02P139259
  • GC02P131251

Summaries for SPOPL Gene

GeneCards Summary for SPOPL Gene

SPOPL (Speckle Type BTB/POZ Protein Like) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Hedgehog. An important paralog of this gene is SPOP.

UniProtKB/Swiss-Prot for SPOPL Gene

  • Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOPL Gene

Genomics for SPOPL Gene

Regulatory Elements for SPOPL Gene

Promoters for SPOPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPOPL on UCSC Golden Path with GeneCards custom track

Genomic Location for SPOPL Gene

Chromosome:
2
Start:
138,501,780 bp from pter
End:
138,573,547 bp from pter
Size:
71,768 bases
Orientation:
Plus strand

Genomic View for SPOPL Gene

Genes around SPOPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOPL Gene

Proteins for SPOPL Gene

  • Protein details for SPOPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IQ16-SPOPL_HUMAN
    Recommended name:
    Speckle-type POZ protein-like
    Protein Accession:
    Q6IQ16

    Protein attributes for SPOPL Gene

    Size:
    392 amino acids
    Molecular mass:
    44647 Da
    Quaternary structure:
    • Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY.

neXtProt entry for SPOPL Gene

Proteomics data for SPOPL Gene at MOPED

Post-translational modifications for SPOPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPOPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPOPL Gene

Domains & Families for SPOPL Gene

Gene Families for SPOPL Gene

Protein Domains for SPOPL Gene

Suggested Antigen Peptide Sequences for SPOPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IQ16

UniProtKB/Swiss-Prot:

SPOPL_HUMAN :
  • Contains 1 BTB (POZ) domain.
  • Belongs to the Tdpoz family.
Domain:
  • Contains 1 BTB (POZ) domain.
  • Contains 1 MATH domain.
Family:
  • Belongs to the Tdpoz family.
genes like me logo Genes that share domains with SPOPL: view

Function for SPOPL Gene

Molecular function for SPOPL Gene

UniProtKB/Swiss-Prot Function:
Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.
genes like me logo Genes that share phenotypes with SPOPL: view

Animal Models for SPOPL Gene

MGI Knock Outs for SPOPL:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPOPL Gene

Localization for SPOPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOPL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPOPL Gene COMPARTMENTS Subcellular localization image for SPOPL gene
Compartment Confidence
nucleus 4
cytosol 3
endosome 1

No data available for Gene Ontology (GO) - Cellular Components for SPOPL Gene

Pathways & Interactions for SPOPL Gene

genes like me logo Genes that share pathways with SPOPL: view

Pathways by source for SPOPL Gene

3 Reactome pathways for SPOPL Gene

UniProtKB/Swiss-Prot Q6IQ16-SPOPL_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for SPOPL Gene

None

No data available for SIGNOR curated interactions for SPOPL Gene

Drugs & Compounds for SPOPL Gene

No Compound Related Data Available

Transcripts for SPOPL Gene

Unigene Clusters for SPOPL Gene

Speckle-type POZ protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPOPL Gene

No ASD Table

Relevant External Links for SPOPL Gene

GeneLoc Exon Structure for
SPOPL
ECgene alternative splicing isoforms for
SPOPL

Expression for SPOPL Gene

mRNA expression in normal human tissues for SPOPL Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPOPL Gene



SOURCE GeneReport for Unigene cluster for SPOPL Gene Hs.333297

genes like me logo Genes that share expression patterns with SPOPL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPOPL Gene

Orthologs for SPOPL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPOPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPOPL 35
  • 95.49 (n)
  • 97.96 (a)
SPOPL 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPOPL 35
  • 96.17 (n)
  • 98.72 (a)
SPOPL 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spopl 35
  • 92.52 (n)
  • 96.43 (a)
Spopl 16
Spopl 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPOPL 35
  • 99.91 (n)
  • 100 (a)
SPOPL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spopl 35
  • 92.09 (n)
  • 96.17 (a)
oppossum
(Monodelphis domestica)
Mammalia SPOPL 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPOPL 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPOPL 35
  • 89.54 (n)
  • 95.41 (a)
SPOPL 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPOPL 36
  • 93 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii spopla 35
  • 77.98 (n)
  • 91.07 (a)
spopla 36
  • 91 (a)
OneToMany
spoplb 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta rdx 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea bath-43 36
  • 52 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons BPM1 35
  • 44.63 (n)
  • 35.2 (a)
rice
(Oryza sativa)
Liliopsida Os07g0655300 35
  • 44.24 (n)
  • 34.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2083 36
  • 72 (a)
OneToMany
Species with no ortholog for SPOPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPOPL Gene

ENSEMBL:
Gene Tree for SPOPL (if available)
TreeFam:
Gene Tree for SPOPL (if available)

Paralogs for SPOPL Gene

Paralogs for SPOPL Gene

(2) SIMAP similar genes for SPOPL Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SPOPL Gene

genes like me logo Genes that share paralogs with SPOPL: view

Variants for SPOPL Gene

Sequence variations from dbSNP and Humsavar for SPOPL Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs36099753 - 138,550,538(-) CCTCT(C/T)GACAA intron-variant, reference, missense, utr-variant-5-prime
rs1053678 -- 138,569,341(+) TTTTT(A/T)TTGTG utr-variant-3-prime
rs1053679 -- 138,569,344(+) TTATT(G/T)TGCCT utr-variant-3-prime
rs1357156 -- 138,554,667(-) TCTGC(A/G)TCACT intron-variant
rs1045918 -- 138,572,487(+) GAACA(A/G)GGATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPOPL Gene

Variant ID Type Subtype PubMed ID
nsv7329 OTHER Inversion 18451855
nsv875159 CNV Gain 21882294
nsv834390 CNV Gain 17160897

Variation tolerance for SPOPL Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPOPL Gene

HapMap Linkage Disequilibrium report
SPOPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOPL Gene

Disorders for SPOPL Gene

Relevant External Links for SPOPL

Genetic Association Database (GAD)
SPOPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPOPL

No disorders were found for SPOPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPOPL Gene

Publications for SPOPL Gene

  1. Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase. (PMID: 22632832) Errington W.J. … Prive G.G. (Structure 2012) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment. (PMID: 23241943) Clark S.L. … van den Oord E.J. (Pharmacogenet. Genomics 2013) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. (PMID: 16651542) Kent D. … Hooper J.E. (Development 2006) 3

Products for SPOPL Gene

Sources for SPOPL Gene

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