SPOPL Gene
protein-coding GIFtS: 43
GCID: GC02P139259
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speckle-type POZ protein-like
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Aliases
for SPOPL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Speckle-Type POZ Protein-Like1 2 | | BTBD331 2 | | Roadkill Homolog 22 3 | | HIB Homolog 22 3 |
Export aliases for SPOPL gene to outside databasesPrevious GC identifers: GC02P138977 GC02P131251 |
Summaries
for SPOPL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16Function: In complex with a cullin, may act in ubiquitination and proteasomal degradation processes (By similarity)
|
Genomic Views
for SPOPL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPOPL gene promoter:
POU2F1 FOXO4 POU2F1a FOXD1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPOPL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOPL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q22.1 Ensembl cytogenetic band: 2q22.1 HGNC cytogenetic band: 2q22.1SPOPL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P139259: view genomic region
(about GC identifiers)
Start:
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139,259,350 bp from pter |
End:
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139,331,117 bp from pter |
Size:
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71,768 bases |
Orientation:
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plus strand |
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Proteins
for SPOPL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16 (See
protein sequence)Recommended Name: Speckle-type POZ protein-like Size: 392 amino acids; 44647 Da
Subcellular location: Nucleus (By similarity)Explore the universe of human proteins at neXtProt for SPOPL: NX_Q6IQ16
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IQ16
SPOPL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001664.1
ENSEMBL proteins: ENSP00000280098 ENSP00000410201 ENSP00000396006
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
SPOPL for ontologies About GeneDecksing
SPOPL Antibody Products:
Assay Products for SPOPL: |
Protein
Domains /
Families
for SPOPL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPOPL for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6IQ16ProtoNet protein and cluster: Q6IQ16 1 Blocks protein family: IPB002083 Meprin/TRAF-like MATH
UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16Similarity: Belongs to the Tdpoz familySimilarity: Contains 1 BTB (POZ) domainSimilarity: Contains 1 MATH domain |
Function
for SPOPL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16Function: In complex with a cullin, may act in ubiquitination and proteasomal degradation processes (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPOPL (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPOPL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPOPL (NM_001001664) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPOPL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOPL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOPL |
4 GenomeRNAi human phenotypes for SPOPL:
|
Pathways & Interactions
for SPOPL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: SPOPL_HUMAN, Q6IQ16Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPOPL
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SPOPL (ENSP000002800984) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- |
SPOPL for ontologies About GeneDecksing
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Drugs & Compounds
for SPOPL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPOPL
Search CenterWatch for drugs/clinical trials and news about SPOPL
|
Transcripts
for SPOPL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SPOPL gene: NM_001001664.2 Unigene Cluster for SPOPL: Speckle-type POZ protein-like Hs.333297 [show with all ESTs]Unigene Representative Sequence: NM_0010016644 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000280098(uc002tvh.3) ENST00000430968 ENST00000420679 ENST00000467775
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPOPL (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPOPL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPOPL (NM_001001664) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPOPL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOPL |
Additional cDNA sequence: AK094583.1 AK293850.1 BC071613.1 BX538143.1 7 DOTS entries: DT.99975092 DT.95295989 DT.410661 DT.86841653 DT.97824745 DT.95151247 DT.95362195 24/141 AceView cDNA sequences (see all 141): BX281767 AL597083 AA199609 CB145288 BQ010147 AA737682 BM785974 AW304714 AA586331 AL700478 AA826451 AA767739 BX099830 AI093132 CK819602 BM129616 BF516590 BE645523 AA947871 AK094583 CK819603 AL597084 BF034206 AA369930
GeneLoc Exon Structure
|
Expression
for SPOPL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPOPL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATCTTGTTG
About this image
See SPOPL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPOPL
SOURCE GeneReport for Unigene cluster: Hs.333297
SABiosciences Custom PCR Arrays for SPOPL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPOPL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPOPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOPL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOPL |
Orthologs
for SPOPL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SPOPL gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for SPOPL (if available)
TreeFam Gene Tree for SPOPL (if available) |
Paralogs
for SPOPL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SPOPL gene
- SPOP2
2 SIMAP similar genes for SPOPL using alignment to 3 protein entries: SPOPL_HUMAN (see all proteins):SPOP BTBD3
SPOPL for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for SPOPL
PGOHUM00000245571 PGOHUM00000245578 PGOHUM00000245949
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Genomic Variants
for SPOPL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPOPL (139259350 - 139331117 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SPOPL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPOPL |
|
Disorders
/ Diseases
for SPOPL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPOPL for disorders About GeneDecksing
2  diseases for SPOPL: About MalaCardspharyngitis neuronitis
Export disorders for SPOPL gene to outside databases
|
Publications
for SPOPL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPOPL gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPOPL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. (PubMed id 16740475)1, 2 Zhang Q.... Jiang J. (2006)
- Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. (PubMed id 16651542)1, 2 Kent D.... Hooper J.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for SPOPL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SPOPL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SPOPL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPOPL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPOPL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SPOPL gene:
Search GeneIP for patents involving SPOPL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPOPL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPOPL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPOPL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPOPL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPOPL | | OriGene 3'-UTR Clone for SPOPL | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPOPL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPOPL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPOPL | | OriGene Custom Protein Services for SPOPL | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPOPL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPOPL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOPL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOPL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOPL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOPL |
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 |  |  |  | |
| | | | Search Tocris compounds for SPOPL |
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 | | | SPOPL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOPL |
|  |  |  | | | | Search ThermoFisher Antibodies for SPOPL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOPL |
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