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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPON2 Gene

protein-coding   GIFtS: 54
GCID: GC04M001150

spondin 2, extracellular matrix protein
 Explore 7 diseases affiliated with
SPON2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPON2    

Aliases
for SPON2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Spondin 2, Extracellular Matrix Protein1 2     M-SPONDIN2
DIL11 2 3     MINDIN2
Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 12 3     Spondin-21
DIL-12 3     Mindin3

External Ids:    HGNC: 112531   Entrez Gene: 104172   Ensembl: ENSG000001596747   OMIM: 6059185   UniProtKB: Q9BUD63   

Export aliases for SPON2 gene to outside databases

Previous GC identifer: GC04M001166


Summaries
for SPON2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6
Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly
to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the
initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial
pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS)




Genomic Views
for SPON2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_037622.5  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPON2 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPON2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPON2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPON2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

SPON2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPON2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M001150:  view genomic region     (about GC identifiers)

Start:
 1,160,720 bp from pter      End:
 1,202,750 bp from pter
Size:
 42,031 bases      Orientation:
 minus strand

Proteins
for SPON2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6 (See protein sequence)
Recommended Name: Spondin-2 precursor  
Size: 331 amino acids; 35846 Da
Subunit: Monomer. Interacts with integrin
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
1 PDB 3D structure from and Proteopedia for SPON2:
3D34 (3D)    
Secondary accessions: Q4W5N4 Q9ULW1

Explore the universe of human proteins at neXtProt for SPON2: NX_Q9BUD6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BUD6

    • SPON2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001121797.1  NP_001185950.1  NP_036577.1  

    ENSEMBL proteins: 
     ENSP00000290902   ENSP00000424542   ENSP00000425871   ENSP00000422516   ENSP00000421634  
     ENSP00000421379   ENSP00000423414   ENSP00000421858   ENSP00000394832  

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    OriGene Protein Over-expression Lysate (see all 2): SPON2
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    Novus Biologicals SPON2 Protein
    Novus Biologicals SPON2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPON2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--


    SPON2 for ontologies           About GeneDecksing



    SPON2 Antibody Products: 
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    Uscn ELISAs and CLIAs for SPON2

    Protein Domains /
    Families
    for SPON2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPON2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000884 Thrombospondin_1_rpt
     IPR009465 Spondin_N

    Graphical View of Domain Structure for InterPro Entry Q9BUD6

    ProtoNet protein and cluster: Q9BUD6

    2 Blocks protein families:
    IPB000884 Thrombospondin
    IPB009465 Spondin


    UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6
    Similarity: Contains 1 spondin domain
    Similarity: Contains 1 TSP type-1 domain


    Function
    for SPON2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6
    Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly
    to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the
    initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial
    pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS)

         Genatlas biochemistry entry for SPON2:
    spondin 2,differentially expressed in cancerous (high expression) and non cancerous lung cells (low expression)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPON2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SPON2:
    hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmid: SPON2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPON2 (see all 7)
    OriGene shRNA RFP: SPON2
    OriGene siRNA: SPON2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPON2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPON2

    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPON2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPON2 

    Cell Line
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    Search LifeMap BioReagents cell lines for SPON2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPON2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0046872metal ion binding IEA--


    SPON2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Spon2tm1Mjb for SPON2
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Spon2):
     homeostasis/metabolism  immune system 

    SPON2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SPON2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    		Inhibition of Angiogenesis by TSP10.37
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3PTEN Pathway
    		PTEN Pathway1.00
    		Phospholipase-C Pathway0.56

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SPON2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPON2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPON2 (ENSP000002909024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAMENSP000002874974STRING: ENSP00000287497
    ITGB2ENSP000003032424STRING: ENSP00000303242
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007411axon guidance TAS10512675
    GO:0045087innate immune response IEA--


    SPON2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPON2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPON2
    Search CenterWatch for drugs/clinical trials and news about SPON2 

    Transcripts
    for SPON2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPON2 gene (3 alternative transcripts): 
    NM_001128325.2  NM_001199021.1  NM_012445.3  

    Unigene Cluster for SPON2:

    Spondin 2, extracellular matrix protein
    Hs.635350  [show with all ESTs]
    Unigene Representative Sequence: AK124606
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000290902(uc003gco.4 uc021xkj.1 uc003gcm.1) ENST00000509697
    ENST00000507466 ENST00000503765 ENST00000504909 ENST00000512888 ENST00000512150
    ENST00000515004 ENST00000502483 ENST00000514490 ENST00000509233 ENST00000511679
    ENST00000511672 ENST00000506266 ENST00000504871 ENST00000502657 ENST00000400762(uc003gcp.3)
    ENST00000505653

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): SPON2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPON2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate SPON2:
    hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmid: SPON2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPON2 (see all 7)
    OriGene shRNA RFP: SPON2
    OriGene siRNA: SPON2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPON2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPON2 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SPON2 (NM_012445)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPON2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPON2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPON2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPON2

    Additional cDNA sequence: 

    AB027466.1 AK074618.1 AK074770.1 AK124606.1 AK130164.1 AY358948.1 BC002707.2 BC036341.1 

    17 DOTS entries:

    DT.100754070  DT.314001  DT.97859062  DT.101957142  DT.100794793  DT.101965468  DT.100683332  DT.101969797 
    DT.101968662  DT.100794804  DT.121254067  DT.100839112  DT.121254037  DT.121254057  DT.121254065  DT.121254084 
    DT.99934062 

    24/254 AceView cDNA sequences (see all 254):

    AI336463 CF139901 CD671595 AA374109 AA658397 CR610928 CA454591 BU683600 
    AW188597 T81066 AI377966 CR607322 CB305638 AI190971 CR594320 CR612649 
    CR596195 AI288103 CA426950 BQ949254 AI866359 BM997077 CR595091 CR596311 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPON2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
    SP1:                                -                 -     -                                         -         
    SP2:              -     -           -                 -     -                                                   
    SP3:              -     -           -                                                                           
    SP4:                                -                                                                           
    SP5:                                                  -     -                                                   


    ECgene alternative splicing isoforms for SPON2

    Expression
    for SPON2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPON2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATGGATCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPON2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Embryoid bodies (Two-step protocol fo...)
    Extraembryonic endoderm-like cells (Generation of extrae...)
    HyStem+TGF?3+GDF5-induced 7SMOO32 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone
    Human kidney epithelial cell spheroids (Kidney spheroids for...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPON2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPON2

    SOURCE GeneReport for Unigene cluster: Hs.635350

    UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6
    Tissue specificity: Expressed in normal lung tissue but not in lung carcinoma cell lines

        SABiosciences Custom PCR Arrays for SPON2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPON2

    Orthologs
    for SPON2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPON2 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Spon21 , 5 spondin 2, extracellular matrix protein1, 5 79.53(n)1
    85.71(a)1    		   5 (17.50 cM)5
    1006891  NM_133903.31  NP_598664.31 
     332135185 
    chicken
    (Gallus gallus)    		 Aves SPON21 spondin 2, extracellular matrix protein 64.64(n)
    70.52(a)    		   422905  XM_420847.3  XP_420847.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SPON26
    --
    		 --
    		 70(a)
    4(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343447.1(618715-630153)
    1(97993454-98045607)
    zebrafish
    (Danio rerio)    		 Actinopterygii spon2b2 spondin 2b, extracellular matrix protein 73.89(n)   30202  AB006085.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mspo1 , 3 M-spondin1 52(a)
    (best of 4)3
    53.47(n)1
    42.92(a)1    		   366321  NM_166063.11  NP_725407.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea spon-16
    		 SPONdin (extracellular matrix glycoprotein) family...
    		 12(a)
    		 1 ↔ 1
    		 II(7116529-7120500)


    ENSEMBL Gene Tree for SPON2 (if available)
    TreeFam Gene Tree for SPON2 (if available) 

    Paralogs
    for SPON2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPON2 gene
    THSD7A2  THSD7B2  
    1 SIMAP similar gene for SPON2 using alignment to 8 protein entries:     SPON2_HUMAN (see all proteins):
    FLJ00108

    SPON2 for paralogs           About GeneDecksing



    Genomic Variants
    for SPON2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for SPON2
         1 CNV: 53617
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPON2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPON2

    Disorders / Diseases
    for SPON2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPON2 for disorders           About GeneDecksing

    OMIM gene information: 605918    OMIM disorders: --

    7 diseases for SPON2:    About MalaCards
    lung carcinoma    nephropathy    prostate cancer    prostatitis
    thyroiditis    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: SPON2 (1 document)

    Export disorders for SPON2 gene to outside databases

    Publications
    for SPON2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPON2 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SPON2)    		    Utopia: connect your pdf to the dynamic
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    1. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PubMed id 10512675)1, 2, 3, 9 Manda R.... Yokota J. (1999)
    2. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. (PubMed id 19153605)1, 2, 9 Li Y....Mariuzza R.A. (2009)
    3. The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities. (PubMed id 15094111)1, 3 Feinstein Y. and Klar A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Spondin-2 (SPON2), a more prostate-cancer-specific dia gnostic biomarker. (PubMed id 22615945)1 Qian X....Zhou J. (2012)
    8. Mindin: a novel marker for podocyte injury in diabeti c nephropathy. (PubMed id 21098016)1 Murakoshi M....Tomino Y. (2011)
    9. Cardiac-specific mindin overexpression attenuates car diac hypertrophy via blocking AKT/GSK3I^ and TGF-I^1-Smad signalling. (PubMed id 21632881)1 Yan L....Li H. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for SPON2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SPON2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10417 HGNC: 11253 AceView: SPON2 Ensembl:ENSG00000159674 euGenes: HUgn10417
    ECgene: SPON2 H-InvDB: SPON2

    Other Databases showing SPON2 gene

    (According to HUGE)
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    Specialized Databases showing SPON2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPON2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPON2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SPON2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for SPON2 gene:
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