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Aliases for SPON2 Gene

Aliases for SPON2 Gene

  • Spondin 2, Extracellular Matrix Protein 2 3
  • Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 1 3 4
  • MINDIN 3 4
  • DIL-1 3 4
  • DIL1 3 4
  • M-Spondin 2
  • M-SPONDIN 3
  • Spondin-2 3
  • Mindin 2

External Ids for SPON2 Gene

Previous GeneCards Identifiers for SPON2 Gene

  • GC04M001166

Summaries for SPON2 Gene

GeneCards Summary for SPON2 Gene

SPON2 (Spondin 2, Extracellular Matrix Protein) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. An important paralog of this gene is THSD7A.

UniProtKB/Swiss-Prot for SPON2 Gene

  • Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPON2 Gene

Genomics for SPON2 Gene

Regulatory Elements for SPON2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPON2 Gene

Start:
1,166,932 bp from pter
End:
1,208,962 bp from pter
Size:
42,031 bases
Orientation:
Minus strand

Genomic View for SPON2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPON2 Gene

Proteins for SPON2 Gene

  • Protein details for SPON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUD6-SPON2_HUMAN
    Recommended name:
    Spondin-2
    Protein Accession:
    Q9BUD6
    Secondary Accessions:
    • D3DVN9
    • Q4W5N4
    • Q9ULW1

    Protein attributes for SPON2 Gene

    Size:
    331 amino acids
    Molecular mass:
    35846 Da
    Quaternary structure:
    • Monomer. Interacts with integrin.

    Three dimensional structures from OCA and Proteopedia for SPON2 Gene

neXtProt entry for SPON2 Gene

Proteomics data for SPON2 Gene at MOPED

Post-translational modifications for SPON2 Gene

  • Glycosylation at Trp283
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SPON2 Gene

Domains for SPON2 Gene

Protein Domains for SPON2 Gene

Suggested Antigen Peptide Sequences for SPON2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BUD6

UniProtKB/Swiss-Prot:

SPON2_HUMAN :
  • Q9BUD6
Domain:
  • Contains 1 spondin domain.
  • Contains 1 TSP type-1 domain.
genes like me logo Genes that share domains with SPON2: view

No data available for Gene Families for SPON2 Gene

Function for SPON2 Gene

Molecular function for SPON2 Gene

GENATLAS Biochemistry: spondin 2,differentially expressed in cancerous (high expression) and non cancerous lung cells (low expression)
UniProtKB/Swiss-Prot Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Gene Ontology (GO) - Molecular Function for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0003823 antigen binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SPON2: view

Phenotypes for SPON2 Gene

genes like me logo Genes that share phenotypes with SPON2: view

Animal Models for SPON2 Gene

MGI Knock Outs for SPON2:

Animal Model Products

CRISPR Products

miRNA for SPON2 Gene

miRTarBase miRNAs that target SPON2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPON2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPON2 Gene

Localization for SPON2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPON2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPON2 Gene COMPARTMENTS Subcellular localization image for SPON2 gene
Compartment Confidence
extracellular 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0031012 extracellular matrix --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SPON2: view

Pathways for SPON2 Gene

genes like me logo Genes that share pathways with SPON2: view

Pathways by source for SPON2 Gene

Interacting Proteins for SPON2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000290902%0d%0a9606.ENSP00000303242%0d%0a9606.ENSP00000441691%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000290902 Q9BUD6-SPON2_HUMAN for SPON2 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002448 mast cell mediated immunity IEA --
GO:0007155 cell adhesion IEA --
GO:0007411 axon guidance TAS 10512675
GO:0008228 opsonization IEA --
GO:0032496 response to lipopolysaccharide --
genes like me logo Genes that share ontologies with SPON2: view

Transcripts for SPON2 Gene

Unigene Clusters for SPON2 Gene

Spondin 2, extracellular matrix protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPON2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPON2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for SPON2 Gene

GeneLoc Exon Structure for
SPON2
ECgene alternative splicing isoforms for
SPON2

Expression for SPON2 Gene

mRNA expression in normal human tissues for SPON2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPON2 Gene

SOURCE GeneReport for Unigene cluster for SPON2 Gene Hs.635350

mRNA Expression by UniProt/SwissProt for SPON2 Gene

Q9BUD6-SPON2_HUMAN
Tissue specificity: Expressed in normal lung tissue but not in lung carcinoma cell lines.
genes like me logo Genes that share expressions with SPON2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SPON2 Gene

Orthologs for SPON2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPON2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPON2 35
  • 99.4 (n)
  • 99.4 (a)
SPON2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPON2 35
  • 82.88 (n)
  • 81.57 (a)
SPON2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102155429 35
  • 79.78 (n)
  • 77.87 (a)
SPON2 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spon2 35
  • 80.33 (n)
  • 88.2 (a)
Spon2 16
Spon2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPON2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPON2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spon2 35
  • 80.87 (n)
  • 89.51 (a)
chicken
(Gallus gallus)
Aves SPON2 35
  • 65.45 (n)
  • 73.84 (a)
SPON2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPON2 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spon2 35
  • 62.36 (n)
  • 65.56 (a)
zebrafish
(Danio rerio)
Actinopterygii spon2b 35
  • 63.25 (n)
  • 64.24 (a)
spon2b 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mspo 35
  • 53.8 (n)
  • 44.19 (a)
mspo 36
  • 21 (a)
OneToOne
CG17739 37
  • 34 (a)
mspo 37
  • 52 (a)
CG30046 37
  • 32 (a)
CG30203 37
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
ManyToMany
Species with no ortholog for SPON2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPON2 Gene

ENSEMBL:
Gene Tree for SPON2 (if available)
TreeFam:
Gene Tree for SPON2 (if available)

Paralogs for SPON2 Gene

Paralogs for SPON2 Gene

Selected SIMAP similar genes for SPON2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPON2: view

Variants for SPON2 Gene

Sequence variations from dbSNP and Humsavar for SPON2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs878323 -- 1,176,025(+) GAGGG(G/T)GACAT intron-variant
rs878324 -- 1,176,063(+) TTTTC(C/T)GGATC intron-variant
rs878325 -- 1,176,150(+) GTGAC(A/G)GAGTG intron-variant
rs1053676 -- 1,167,080(-) GTGCT(C/T)TAGGC utr-variant-3-prime
rs1383658 -- 1,177,289(+) TGCTG(C/T)GGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPON2 Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
nsv829835 CNV Gain 17160897
nsv878328 CNV Loss 21882294
dgv5401n71 CNV Loss 21882294
nsv878330 CNV Loss 21882294
nsv519106 CNV Loss 19592680
dgv636n27 CNV Loss 19166990
esv2726766 CNV Deletion 23290073
dgv5402n71 CNV Loss 21882294
nsv508988 CNV Insertion 20534489
nsv293242 CNV Loss 16902084
esv2726767 CNV Deletion 23290073
esv2726768 CNV Deletion 23290073

Relevant External Links for SPON2 Gene

HapMap Linkage Disequilibrium report
SPON2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPON2 Gene

Disorders for SPON2 Gene

Relevant External Links for SPON2

Genetic Association Database (GAD)
SPON2
Human Genome Epidemiology (HuGE) Navigator
SPON2
genes like me logo Genes that share disorders with SPON2: view

No data available for UniProtKB/Swiss-Prot for SPON2 Gene

Publications for SPON2 Gene

  1. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PMID: 10512675) Manda R. … Yokota J. (Genomics 1999) 2 3 4 23
  2. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. (PMID: 19153605) Li Y. … Mariuzza R.A. (EMBO J. 2009) 3 4 23
  3. Sequence variants in the RNF212 gene associate with genome-wide recombination rate. (PMID: 18239089) Kong A. … Stefansson K. (Science 2008) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for SPON2 Gene

Sources for SPON2 Gene

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