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SPON2 Gene

protein-coding   GIFtS: 60
GCID: GC04M001150

Spondin 2, Extracellular Matrix Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Spondin 2, Extracellular Matrix Protein1 2     M-spondin1
Mindin1 3     M-SPONDIN2
Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 12 3     MINDIN2
DIL-12 3     spondin-22
DIL12 3     

External Ids:    HGNC: 112531   Entrez Gene: 104172   Ensembl: ENSG000001596747   OMIM: 6059185   UniProtKB: Q9BUD63   
ORGUL members:         

Export aliases for SPON2 gene to outside databases

Previous GC identifer: GC04M001166


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPON2 Gene:
SPON2 (spondin 2, extracellular matrix protein) is a protein-coding gene. Diseases associated with SPON2 include uterine fibroid, and diabetic nephropathy. An important paralog of this gene is THSD7A.

UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6
Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds
directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria.
Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in
the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPON2 gene promoter:
         E2F-4   E2F-3a   E2F-1   E2F   E2F-2   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPON2 promoter sequence
   Search Chromatin IP Primers for SPON2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPON2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

SPON2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPON2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M001150:  view genomic region     (about GC identifiers)

Start:
1,160,720 bp from pter      End:
1,202,750 bp from pter
Size:
42,031 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6 (See protein sequence)
Recommended Name: Spondin-2 precursor  
Size: 331 amino acids; 35846 Da
Subunit: Monomer. Interacts with integrin
1 PDB 3D structure from and Proteopedia for SPON2:
3D34 (3D)    
Secondary accessions: D3DVN9 Q4W5N4 Q9ULW1

Explore the universe of human proteins at neXtProt for SPON2: NX_Q9BUD6

Explore proteomics data for SPON2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Trp283
  • Modification sites at PhosphoSitePlus

  • See SPON2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001121797.1  NP_001185950.1  NP_036577.1  

    ENSEMBL proteins: 
     ENSP00000290902   ENSP00000424542   ENSP00000425871   ENSP00000422516   ENSP00000421634  
     ENSP00000421379   ENSP00000423414   ENSP00000421858   ENSP00000394832  
    Reactome Protein details: Q9BUD6

    SPON2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SPON2
    OriGene Custom MassSpec
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    Novus Biologicals SPON2 Protein
    Novus Biologicals SPON2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPON2

    SPON2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SPON2 (Mindin)
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    LSBio Antibodies in human, mouse, rat for SPON2

    SPON2 Assay Products:

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    Cloud-Clone Corp. ELISAs for SPON2
    Cloud-Clone Corp. CLIAs for SPON2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000884 Thrombospondin_1_rpt
     IPR009465 Spondin_N

    Graphical View of Domain Structure for InterPro Entry Q9BUD6

    ProtoNet protein and cluster: Q9BUD6

    2 Blocks protein domains:
    IPB000884 Thrombospondin
    IPB009465 Spondin


    UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6
    Similarity: Contains 1 spondin domain
    Similarity: Contains 1 TSP type-1 domain


    SPON2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPON2_HUMAN, Q9BUD6
    Function: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds
    directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria.
    Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in
    the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS)

         Genatlas biochemistry entry for SPON2:
    spondin 2,differentially expressed in cancerous (high expression) and non cancerous lung cells (low expression)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046872metal ion binding IEA--
         
    SPON2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spon2):
     homeostasis/metabolism  immune system 

    SPON2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Spon2tm1Mjb for SPON2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPON2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPON2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPON2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPON2

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPON2:
    hsa-mir-9-5p (MIRT021428)

    Block miRNA regulation of human, mouse, rat SPON2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SPON2:
    hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidSPON2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPON2
    Predesigned siRNA for gene silencing in human, mouse, rat SPON2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): SPON2 (NM_012445)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPON2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPON2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPON2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPON2_HUMAN, Q9BUD6: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    SPON2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPON2 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SPON2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway

    1 Reactome Pathway for SPON2
        O-glycosylation of TSR domain-containing proteins



    SPON2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPON2
    Interactions:

        Search GeneGlobe Interaction Network for SPON2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for SPON2 (ENSP000002909024) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGAMENSP000002874974STRING: ENSP00000287497
    ITGB2ENSP000003032424STRING: ENSP00000303242
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007411axon guidance TAS10512675
    GO:0045087innate immune response IEA--

    SPON2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPON2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPON2 gene (3 alternative transcripts): 
    NM_001128325.2  NM_001199021.1  NM_012445.3  

    Unigene Cluster for SPON2:

    Spondin 2, extracellular matrix protein
    Hs.635350  [show with all ESTs]
    Unigene Representative Sequence: AK124606
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000290902(uc003gco.4 uc021xkj.1 uc003gcm.1) ENST00000509697
    ENST00000507466 ENST00000503765 ENST00000504909 ENST00000512888 ENST00000512150
    ENST00000515004 ENST00000502483 ENST00000514490 ENST00000509233 ENST00000511679
    ENST00000511672 ENST00000506266 ENST00000504871 ENST00000502657 ENST00000400762(uc003gcp.3)
    ENST00000505653
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPON2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate SPON2:
    hsa-miR-202
    SwitchGear 3'UTR luciferase reporter plasmidSPON2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPON2
    Predesigned siRNA for gene silencing in human, mouse, rat SPON2
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SPON2 (NM_012445)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPON2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPON2
    Primer
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    OriGene qPCR primer pairs and template standards for SPON2
    OriGene qSTAR qPCR primer pairs in human, mouse for SPON2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPON2
      QuantiTect SYBR Green Assays in human, mouse, rat SPON2
      QuantiFast Probe-based Assays in human, mouse, rat SPON2

    Additional mRNA sequence: 

    AB027466.1 AK074618.1 AK074770.1 AK124606.1 AK130164.1 AY358948.1 BC002707.2 BC036341.1 

    17 DOTS entries:

    DT.100754070  DT.314001  DT.97859062  DT.101957142  DT.100794793  DT.101965468  DT.100683332  DT.101969797 
    DT.101968662  DT.100794804  DT.121254067  DT.100839112  DT.121254037  DT.121254057  DT.121254065  DT.121254084 
    DT.99934062 

    Selected AceView cDNA sequences (see all 254):

    AI367500 CR594320 CR604996 AI866359 AI336463 BU623072 CR596362 BE047605 
    AW188597 BQ949254 CR607322 AA235464 AI799666 CR592321 AA658397 CF139901 
    AI190971 CR626363 CR597252 AI288103 CR596195 BM997077 CR593652 AI274628 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPON2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
    SP1:                                -                 -     -                                         -         
    SP2:              -     -           -                 -     -                                                   
    SP3:              -     -           -                                                                           
    SP4:                                -                                                                           
    SP5:                                                  -     -                                                   


    ECgene alternative splicing isoforms for SPON2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPON2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATGGATCT
    SPON2 Expression
    About this image


    SPON2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 4 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Natural Killer Cells Peripheral Blood
             Umbilical cord blood-derived mesenchymal stem cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             TGFbeta3+BMP7-induced chondrocytes
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
    SPON2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPON2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.635350

    UniProtKB/Swiss-Prot: SPON2_HUMAN, Q9BUD6
    Tissue specificity: Expressed in normal lung tissue but not in lung carcinoma cell lines

        Custom PCR Arrays for SPON2
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    QuantiFast Probe-based Assays in human, mouse, rat SPON2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPON2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPON2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spon21 , 5 spondin 2, extracellular matrix protein1, 5 80.33(n)1
    88.2(a)1
      5 (17.50 cM)5
    1006891  NM_133903.31  NP_598664.31 
     332135185 
    chicken
    (Gallus gallus)
    Aves SPON21 spondin 2, extracellular matrix protein 65.45(n)
    73.84(a)
      422905  XM_420847.4  XP_420847.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPON26
    spondin 2, extracellular matrix protein
    69(a)
    1 ↔ 1
    GL343447.1(615026-631059)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia spon21 spondin 2, extracellular matrix protein 62.36(n)
    65.56(a)
      780015  NM_001079092.1  NP_001072560.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spon2b2 spondin 2b, extracellular matrix protein 73.89(n)   30202  AB006085.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mspo1 , 3 M-spondin1 52(a)
    (best of 4)3
    53.8(n)1
    44.19(a)1
      366321  NM_166063.21  NP_725407.11 


    ENSEMBL Gene Tree for SPON2 (if available)
    TreeFam Gene Tree for SPON2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPON2 gene
    THSD7A2  THSD7B2  
    1 SIMAP similar gene for SPON2 using alignment to 7 protein entries:     SPON2_HUMAN (see all proteins):
    FLJ00108

    SPON2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPON2 (see all 693)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1460946071,2
    --1160222(+) GGCCAC/TGACAG 3 -- int10--------
    rs744402591,2
    C,F--1160344(+) CCCCCA/GTGAAC 3 -- int11Minor allele frequency- G:0.08EA 120
    rs1397412041,2
    --1160448(+) TGATCA/GTCCTG 3 -- int10--------
    rs1497777391,2
    --1160463(+) CAGGCA/GCGTGC 3 -- int10--------
    rs285403721,2
    C,F--1160465(+) GGCGCG/CTGCCT 3 -- int14Minor allele frequency- C:0.24WA NA EA 360
    rs1897067591,2
    --1160517(+) TTCTGA/GAATCC 3 -- int10--------
    rs730677061,2
    C,F--1160559(+) GAGATC/TTGTAG 3 -- int15Minor allele frequency- T:0.28WA CSA NA 243
    rs1812917361,2
    --1160584(+) TCCCAC/TACACA 3 -- int10--------
    rs1850674251,2
    C--1160649(+) GTGTCC/TCCAAT 3 -- int10--------
    rs1898801791,2
    --1160789(+) GCTTCC/TGAAAC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for SPON2 (1160720 - 1202750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPON2 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726768CNV Deletion23290073
    esv2726767CNV Deletion23290073
    esv2726766CNV Deletion23290073
    nsv508988CNV Insertion20534489
    dgv636n27CNV Loss19166990
    nsv519106CNV Loss19592680
    dgv5401n71CNV Loss21882294
    nsv878330CNV Loss21882294
    nsv293242CNV Loss16902084
    nsv878328CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605918    OMIM disorders: --

    7 diseases for SPON2:    
    About MalaCards
    uterine fibroid    diabetic nephropathy    prostate cancer    prostatitis
    thyroiditis    neuronitis    endotheliitis


    SPON2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPON2
    Human Genome Epidemiology (HuGE) Navigator: SPON2 (1 document)

    Export disorders for SPON2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPON2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with SPON2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PubMed id 10512675)1, 2, 3, 9 Manda R.... Yokota J. (Genomics 1999)
    2. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. (PubMed id 19153605)1, 2, 9 Li Y....Mariuzza R.A. (EMBO J. 2009)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Sequence variants in the RNF212 gene associate with genome-wide recombination rate. (PubMed id 18239089)1, 4 Kong A.... Stefansson K. (Science 2008)
    5. The neuronal class 2 TSR proteins F-spondin and Mindin: a small family with divergent biological activities. (PubMed id 15094111)1, 3 Feinstein Y. and Klar A. (amp 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker. (PubMed id 22615945)1 Qian X....Zhou J. (PLoS ONE 2012)
    10. Mindin: a novel marker for podocyte injury in diabetic nephropathy. (PubMed id 21098016)1 Murakoshi M....Tomino Y. (Nephrol. Dial. Transplant. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10417 HGNC: 11253 AceView: SPON2 Ensembl:ENSG00000159674 euGenes: HUgn10417
    ECgene: SPON2 H-InvDB: SPON2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SPON2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPON2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SPON2 gene:
    Search GeneIP for patents involving SPON2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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