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Aliases for SPON2 Gene

Aliases for SPON2 Gene

  • Spondin 2 2 3 5
  • Mindin 2 3 4
  • Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 1 3 4
  • Spondin 2, Extracellular Matrix Protein 2 3
  • M-Spondin 2 3
  • DIL-1 3 4
  • DIL1 3 4
  • Spondin-2 3

External Ids for SPON2 Gene

Previous GeneCards Identifiers for SPON2 Gene

  • GC04M001166

Summaries for SPON2 Gene

GeneCards Summary for SPON2 Gene

SPON2 (Spondin 2) is a Protein Coding gene. Among its related pathways are Phospholipase-C Pathway and O-glycosylation of TSR domain-containing proteins. GO annotations related to this gene include antigen binding and lipopolysaccharide binding. An important paralog of this gene is SPON1.

UniProtKB/Swiss-Prot for SPON2 Gene

  • Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPON2 Gene

Genomics for SPON2 Gene

Regulatory Elements for SPON2 Gene

Enhancers for SPON2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G001170 1.5 Ensembl ENCODE dbSUPER 13 +36.4 36399 3.8 HNRNPUL1 HDGF FOXA2 PKNOX1 SIN3A ZNF2 CBX5 ZNF143 ZNF207 KLF13 UVSSA SPON2 ENSG00000251188 CTBP1-AS2 CTBP1 MAEA ZNF732 CRIPAK ENSG00000273179 ENSG00000251639
GH04G001293 1.2 Ensembl ENCODE 11.4 -85.8 -85818 1.9 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 GLIS2 MXD4 MXD3 GLIS1 CRIPAK MAEA CTBP1 CTBP1-AS2 SPON2 RNF212 UVSSA GC04M001299
GH04G001288 1.1 ENCODE 11.4 -81.1 -81068 3.5 PKNOX1 CREB3L1 ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF143 FOS SP3 MAEA UVSSA HAUS3 CTBP1 CTBP1-AS2 SPON2 FGFRL1 GC04M001299
GH04G001267 1.1 Ensembl ENCODE 11.3 -58.9 -58874 1.6 PKNOX1 FOXA2 RB1 ZNF2 RAD21 ZNF143 ZNF207 RELB IKZF2 ZNF654 UVSSA MAEA CRIPAK ABCA11P ZNF732 ENSG00000251188 ZNF141 SPON2 LOC100129917 TMEM129
GH04G001228 0.5 dbSUPER 13 -20.5 -20456 1.9 ZFHX2 KLF1 POLR2A MNT EGR2 CRIPAK CTBP1-AS2 SPON2 CTBP1 MAEA LOC105374344 RNF212 CTBP1-AS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPON2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPON2 Gene

Chromosome:
4
Start:
1,166,932 bp from pter
End:
1,208,962 bp from pter
Size:
42,031 bases
Orientation:
Minus strand

Genomic View for SPON2 Gene

Genes around SPON2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPON2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPON2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPON2 Gene

Proteins for SPON2 Gene

  • Protein details for SPON2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUD6-SPON2_HUMAN
    Recommended name:
    Spondin-2
    Protein Accession:
    Q9BUD6
    Secondary Accessions:
    • D3DVN9
    • Q4W5N4
    • Q9ULW1

    Protein attributes for SPON2 Gene

    Size:
    331 amino acids
    Molecular mass:
    35846 Da
    Quaternary structure:
    • Monomer. Interacts with integrin.

    Three dimensional structures from OCA and Proteopedia for SPON2 Gene

neXtProt entry for SPON2 Gene

Post-translational modifications for SPON2 Gene

  • Glycosylation at isoforms=283
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for SPON2 Gene

Domains & Families for SPON2 Gene

Protein Domains for SPON2 Gene

Suggested Antigen Peptide Sequences for SPON2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPON2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPON2 Gene

Function for SPON2 Gene

Molecular function for SPON2 Gene

GENATLAS Biochemistry:
spondin 2,differentially expressed in cancerous (high expression) and non cancerous lung cells (low expression)
UniProtKB/Swiss-Prot Function:
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).

Gene Ontology (GO) - Molecular Function for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IEA --
GO:0003823 antigen binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SPON2: view
genes like me logo Genes that share phenotypes with SPON2: view

Animal Models for SPON2 Gene

MGI Knock Outs for SPON2:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPON2

CRISPR Products

miRNA for SPON2 Gene

miRTarBase miRNAs that target SPON2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPON2 Gene

Localization for SPON2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPON2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPON2 gene
Compartment Confidence
extracellular 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SPON2: view

Pathways & Interactions for SPON2 Gene

genes like me logo Genes that share pathways with SPON2: view

Interacting Proteins for SPON2 Gene

Gene Ontology (GO) - Biological Process for SPON2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002448 mast cell mediated immunity IEA --
GO:0007155 cell adhesion IEA --
GO:0007411 axon guidance TAS 10512675
GO:0008228 opsonization IEA --
genes like me logo Genes that share ontologies with SPON2: view

No data available for SIGNOR curated interactions for SPON2 Gene

Drugs & Compounds for SPON2 Gene

No Compound Related Data Available

Transcripts for SPON2 Gene

Unigene Clusters for SPON2 Gene

Spondin 2, extracellular matrix protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPON2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6:
SP7:

Relevant External Links for SPON2 Gene

GeneLoc Exon Structure for
SPON2
ECgene alternative splicing isoforms for
SPON2

Expression for SPON2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPON2 Gene

Protein differential expression in normal tissues from HIPED for SPON2 Gene

This gene is overexpressed in Amniocyte (59.1) and Synovial fluid (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPON2 Gene



Protein tissue co-expression partners for SPON2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPON2 Gene:

SPON2

SOURCE GeneReport for Unigene cluster for SPON2 Gene:

Hs.635350

mRNA Expression by UniProt/SwissProt for SPON2 Gene:

Q9BUD6-SPON2_HUMAN
Tissue specificity: Expressed in normal lung tissue but not in lung carcinoma cell lines.

Evidence on tissue expression from TISSUES for SPON2 Gene

  • Intestine(4.3)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with SPON2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPON2 Gene

Orthologs for SPON2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPON2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPON2 34 35
  • 99.4 (n)
cow
(Bos Taurus)
Mammalia SPON2 34 35
  • 82.88 (n)
rat
(Rattus norvegicus)
Mammalia Spon2 34
  • 80.87 (n)
mouse
(Mus musculus)
Mammalia Spon2 34 16 35
  • 80.33 (n)
dog
(Canis familiaris)
Mammalia LOC102155429 34
  • 79.78 (n)
SPON2 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPON2 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPON2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPON2 34 35
  • 65.45 (n)
lizard
(Anolis carolinensis)
Reptilia SPON2 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spon2 34
  • 62.36 (n)
zebrafish
(Danio rerio)
Actinopterygii spon2b 34 35
  • 63.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta mspo 36 34 35
  • 53.8 (n)
CG17739 36
  • 34 (a)
CG30046 36
  • 32 (a)
CG30203 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 13 (a)
ManyToMany
Species where no ortholog for SPON2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPON2 Gene

ENSEMBL:
Gene Tree for SPON2 (if available)
TreeFam:
Gene Tree for SPON2 (if available)

Paralogs for SPON2 Gene

Paralogs for SPON2 Gene

(1) SIMAP similar genes for SPON2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPON2: view

Variants for SPON2 Gene

Sequence variations from dbSNP and Humsavar for SPON2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000124113 -- 1,203,125(+) AGCCT(A/G)CCGGC intron-variant, upstream-variant-2KB
rs1000231576 -- 1,178,687(+) CAGGG(-/T)TTTTT intron-variant
rs1000254855 -- 1,186,046(+) GAGAC(C/T)ATCCT intron-variant
rs1000437332 -- 1,201,651(+) GATCT(C/T)GGCTC intron-variant, upstream-variant-2KB
rs1000470940 -- 1,209,602(+) TTAAG(C/T)GTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPON2 Gene

Variant ID Type Subtype PubMed ID
dgv636n27 CNV loss 19166990
dgv8890n54 CNV loss 21841781
dgv8891n54 CNV loss 21841781
esv2726766 CNV deletion 23290073
esv2726767 CNV deletion 23290073
esv2726768 CNV deletion 23290073
nsv1012892 CNV loss 25217958
nsv1074662 CNV deletion 25765185
nsv293242 CNV deletion 16902084
nsv475579 CNV novel sequence insertion 20440878
nsv508988 CNV insertion 20534489
nsv519106 CNV loss 19592680
nsv593278 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv829835 CNV gain 17160897
nsv950331 CNV deletion 24416366

Variation tolerance for SPON2 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 71.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPON2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPON2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPON2 Gene

Disorders for SPON2 Gene

Relevant External Links for SPON2

Genetic Association Database (GAD)
SPON2
Human Genome Epidemiology (HuGE) Navigator
SPON2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPON2

No disorders were found for SPON2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPON2 Gene

Publications for SPON2 Gene

  1. Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display. (PMID: 10512675) Manda R. … Yokota J. (Genomics 1999) 2 3 4 22 64
  2. Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. (PMID: 19153605) Li Y. … Mariuzza R.A. (EMBO J. 2009) 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Sequence variants in the RNF212 gene associate with genome-wide recombination rate. (PMID: 18239089) Kong A. … Stefansson K. (Science 2008) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for SPON2 Gene

Sources for SPON2 Gene

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