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Aliases for SPON1 Gene

Aliases for SPON1 Gene

  • Spondin 1, Extracellular Matrix Protein 2 3
  • Spondin 1, (F-Spondin) Extracellular Matrix Protein 2 3
  • Vascular Smooth Muscle Cell Growth-Promoting Factor 3 4
  • F-Spondin 3 4
  • VSGP/F-Spondin 3
  • Spondin-1 3
  • KIAA0762 4
  • VSGP 4

External Ids for SPON1 Gene

Previous GeneCards Identifiers for SPON1 Gene

  • GC11P015256
  • GC11P014734
  • GC11P014023
  • GC11P013948
  • GC11P013663

Summaries for SPON1 Gene

GeneCards Summary for SPON1 Gene

SPON1 (Spondin 1, Extracellular Matrix Protein) is a Protein Coding gene. Among its related pathways are NF-KappaB Family Pathway and NF-KappaB Family Pathway.

UniProtKB/Swiss-Prot for SPON1 Gene

  • Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.

Gene Wiki entry for SPON1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPON1 Gene

Genomics for SPON1 Gene

Regulatory Elements for SPON1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPON1 Gene

Start:
13,962,637 bp from pter
End:
14,268,133 bp from pter
Size:
305,497 bases
Orientation:
Plus strand

Genomic View for SPON1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPON1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPON1 Gene

Proteins for SPON1 Gene

  • Protein details for SPON1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCB6-SPON1_HUMAN
    Recommended name:
    Spondin-1
    Protein Accession:
    Q9HCB6
    Secondary Accessions:
    • A8K6W5
    • O94862
    • Q8NCD7
    • Q8WUR5

    Protein attributes for SPON1 Gene

    Size:
    807 amino acids
    Molecular mass:
    90973 Da
    Quaternary structure:
    • Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.

    Three dimensional structures from OCA and Proteopedia for SPON1 Gene

neXtProt entry for SPON1 Gene

Proteomics data for SPON1 Gene at MOPED

Post-translational modifications for SPON1 Gene

  • Glycosylation at Thr192, Asn214, Trp448, Trp451, Trp507, Trp510, Trp564, Trp620, Trp623, Trp674, and Asn681
  • Modification sites at PhosphoSitePlus

Other Protein References for SPON1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SPON1 (F-Spondin/SPON1)

No data available for DME Specific Peptides for SPON1 Gene

Domains for SPON1 Gene

Suggested Antigen Peptide Sequences for SPON1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCB6

UniProtKB/Swiss-Prot:

SPON1_HUMAN :
  • Q9HCB6
Domain:
  • Contains 1 reelin domain.
  • Contains 1 spondin domain.
  • Contains 6 TSP type-1 domains.
genes like me logo Genes that share domains with SPON1: view

No data available for Gene Families for SPON1 Gene

Function for SPON1 Gene

Molecular function for SPON1 Gene

GENATLAS Biochemistry:
spondin 1 (f-spondin) extracellular matrix protein
UniProtKB/Swiss-Prot Function:
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.

Gene Ontology (GO) - Molecular Function for SPON1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14983046
genes like me logo Genes that share ontologies with SPON1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPON1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPON1 Gene

Localization for SPON1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPON1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPON1 Gene COMPARTMENTS Subcellular localization image for SPON1 gene
Compartment Confidence
extracellular 4
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPON1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with SPON1: view

Pathways for SPON1 Gene

genes like me logo Genes that share pathways with SPON1: view

Pathways by source for SPON1 Gene

Interacting Proteins for SPON1 Gene

Gene Ontology (GO) - Biological Process for SPON1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0007155 cell adhesion IEA --
GO:0036066 protein O-linked fucosylation TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SPON1: view

Compounds for SPON1 Gene

(1) Novoseek inferred chemical compound relationships for SPON1 Gene

Compound -log(P) Hits PubMed IDs
vegf 27.9 3
genes like me logo Genes that share compounds with SPON1: view

Transcripts for SPON1 Gene

mRNA/cDNA for SPON1 Gene

(248) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPON1 Gene

Spondin 1, extracellular matrix protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPON1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPON1 Gene

No ASD Table

Relevant External Links for SPON1 Gene

GeneLoc Exon Structure for
SPON1
ECgene alternative splicing isoforms for
SPON1

Expression for SPON1 Gene

mRNA expression in normal human tissues for SPON1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SPON1 Gene

This gene is overexpressed in Vitreous humor (33.9) and Heart (7.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SPON1 Gene

SOURCE GeneReport for Unigene cluster for SPON1 Gene Hs.643864

mRNA Expression by UniProt/SwissProt for SPON1 Gene

Q9HCB6-SPON1_HUMAN
Tissue specificity: Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.
genes like me logo Genes that share expressions with SPON1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for SPON1 Gene

Orthologs for SPON1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPON1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPON1 35
  • 92.61 (n)
  • 97.52 (a)
dog
(Canis familiaris)
Mammalia SPON1 35
  • 92.81 (n)
  • 98.27 (a)
mouse
(Mus musculus)
Mammalia Spon1 35
  • 89.63 (n)
  • 96.28 (a)
Spon1 16
chimpanzee
(Pan troglodytes)
Mammalia SPON1 35
  • 99.63 (n)
  • 99.75 (a)
rat
(Rattus norvegicus)
Mammalia Spon1 35
  • 89.43 (n)
  • 96.78 (a)
chicken
(Gallus gallus)
Aves SPON1 35
  • 78.56 (n)
  • 89.22 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spon1 35
  • 77.15 (n)
  • 86.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia spon1-A 35
zebrafish
(Danio rerio)
Actinopterygii spon1a 35
  • 70.79 (n)
  • 79.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17739 37
  • 25 (a)
CG30046 37
  • 31 (a)
CG30203 37
  • 31 (a)
fat-spondin 37
  • 32 (a)
CG17739 35
  • 48.49 (n)
  • 38.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012307 35
  • 42.77 (n)
  • 30.77 (a)
worm
(Caenorhabditis elegans)
Secernentea F10E7.4 37
  • 27 (a)
Species with no ortholog for SPON1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPON1 Gene

ENSEMBL:
Gene Tree for SPON1 (if available)
TreeFam:
Gene Tree for SPON1 (if available)

Paralogs for SPON1 Gene

No data available for Paralogs for SPON1 Gene

Variants for SPON1 Gene

Sequence variations from dbSNP and Humsavar for SPON1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8964 -- 14,267,031(+) TTCTT(C/T)TTTTA utr-variant-3-prime
rs11238 -- 14,266,582(+) TAGAC(G/T)TTCAA utr-variant-3-prime
rs11369 -- 14,266,550(+) TGCCT(A/G)AATTT utr-variant-3-prime
rs11565 -- 14,267,107(+) ACTAC(A/G)AATTT utr-variant-3-prime
rs12152 -- 14,267,664(+) AACAT(G/T)ACTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPON1 Gene

Variant ID Type Subtype PubMed ID
esv2668036 CNV Deletion 23128226
nsv897004 CNV Loss 21882294
esv2597158 CNV Deletion 19546169
esv1173943 CNV Deletion 17803354
esv1763444 CNV Insertion 17803354
esv29123 CNV Loss 19812545

Relevant External Links for SPON1 Gene

HapMap Linkage Disequilibrium report
SPON1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPON1 Gene

Disorders for SPON1 Gene

Relevant External Links for SPON1

Genetic Association Database (GAD)
SPON1
Human Genome Epidemiology (HuGE) Navigator
SPON1

No disorders were found for SPON1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPON1 Gene

Publications for SPON1 Gene

  1. Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary. (PMID: 11368520) Miyamoto K. … Minegishi T. (Arch. Biochem. Biophys. 2001) 3 4 23
  2. The crystal structure of the heparin-binding reelin-N domain of f- spondin. (PMID: 18602404) Tan K. … Wang J.H. (J. Mol. Biol. 2008) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  4. C-mannosylation and O-fucosylation of thrombospondin type 1 repeats. (PMID: 12096136) Gonzalez de Peredo A. … Hofsteenge J. (Mol. Cell. Proteomics 2002) 3 4
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4

Products for SPON1 Gene

Sources for SPON1 Gene

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