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Aliases for SPON1 Gene

Aliases for SPON1 Gene

  • Spondin 1 2 3 5
  • Spondin 1, (F-Spondin) Extracellular Matrix Protein 2 3
  • Vascular Smooth Muscle Cell Growth-Promoting Factor 3 4
  • F-Spondin 3 4
  • Spondin 1, Extracellular Matrix Protein 3
  • VSGP/F-Spondin 3
  • Spondin-1 3
  • KIAA0762 4
  • VSGP 4

External Ids for SPON1 Gene

Previous GeneCards Identifiers for SPON1 Gene

  • GC11P015256
  • GC11P014734
  • GC11P014023
  • GC11P013948
  • GC11P013663

Summaries for SPON1 Gene

GeneCards Summary for SPON1 Gene

SPON1 (Spondin 1) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Phospholipase-C Pathway. An important paralog of this gene is THSD7A.

UniProtKB/Swiss-Prot for SPON1 Gene

  • Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.

Gene Wiki entry for SPON1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPON1 Gene

Genomics for SPON1 Gene

Regulatory Elements for SPON1 Gene

Enhancers for SPON1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G014028 1 Ensembl ENCODE 18 +67.2 67172 2.1 NFIB FEZF1 ZBTB40 E2F1 ZFHX2 CTBP1 EGR1 FOS MAFK EGR2 SPON1 GC11M013996 GC11M014052
GH11G014015 1.1 Ensembl ENCODE 15.1 +53.2 53161 1.5 PKNOX1 ESRRA JUN INSM2 ZNF644 RARA TEAD3 CTBP1 GATA3 GATA2 SPON1 GC11M013996 GC11M014052
GH11G014421 1.6 FANTOM5 Ensembl ENCODE 9.8 +460.5 460528 3.8 HDGF SIN3A TCF12 ZNF766 GATA2 FOS DEK MAFF SMARCA4 PBX2 SPON1-AS1 SPON1 COPB1 RRAS2 LOC105376670
GH11G013962 1.4 FANTOM5 Ensembl ENCODE 8.8 +2.7 2734 6.1 ZNF2 RAD21 ZNF366 ZNF263 CEBPB REST ZNF843 CBX8 ZNF341 CEBPA SPON1 GC11M013996
GH11G014373 1 Ensembl ENCODE 10.8 +412.1 412116 2.1 ELF3 CTCF MAX CEBPG RAD21 YY1 NCOR1 HNF4G ZNF3 JUNB SPON1 RRAS2 LOC105376670
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPON1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPON1 Gene

Chromosome:
11
Start:
13,962,637 bp from pter
End:
14,268,133 bp from pter
Size:
305,497 bases
Orientation:
Plus strand

Genomic View for SPON1 Gene

Genes around SPON1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPON1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPON1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPON1 Gene

Proteins for SPON1 Gene

  • Protein details for SPON1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCB6-SPON1_HUMAN
    Recommended name:
    Spondin-1
    Protein Accession:
    Q9HCB6
    Secondary Accessions:
    • A8K6W5
    • O94862
    • Q8NCD7
    • Q8WUR5

    Protein attributes for SPON1 Gene

    Size:
    807 amino acids
    Molecular mass:
    90973 Da
    Quaternary structure:
    • Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.

    Three dimensional structures from OCA and Proteopedia for SPON1 Gene

neXtProt entry for SPON1 Gene

Post-translational modifications for SPON1 Gene

  • Glycosylation at isoforms=192, posLast=214214, posLast=448448, Trp451, posLast=507507, isoforms=510, isoforms=564, Trp620, isoforms=623, Trp674, and Asn681
  • Modification sites at PhosphoSitePlus

Other Protein References for SPON1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SPON1 (F-Spondin/SPON1)
  • Cloud-Clone Corp. Antibodies for SPON1

No data available for DME Specific Peptides for SPON1 Gene

Domains & Families for SPON1 Gene

Suggested Antigen Peptide Sequences for SPON1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPON1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for SPON1 Gene

Function for SPON1 Gene

Molecular function for SPON1 Gene

GENATLAS Biochemistry:
spondin 1 (f-spondin) extracellular matrix protein
UniProtKB/Swiss-Prot Function:
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.

Gene Ontology (GO) - Molecular Function for SPON1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14983046
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with SPON1: view
genes like me logo Genes that share phenotypes with SPON1: view

Animal Models for SPON1 Gene

MGI Knock Outs for SPON1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPON1

miRNA for SPON1 Gene

miRTarBase miRNAs that target SPON1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPON1 Gene

Localization for SPON1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPON1 Gene

Secreted, extracellular space, extracellular matrix.

Gene Ontology (GO) - Cellular Components for SPON1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0031012 colocalizes_with extracellular matrix ISS 22261194
genes like me logo Genes that share ontologies with SPON1: view

No data available for Subcellular locations from COMPARTMENTS for SPON1 Gene

Pathways & Interactions for SPON1 Gene

genes like me logo Genes that share pathways with SPON1: view

Interacting Proteins for SPON1 Gene

Gene Ontology (GO) - Biological Process for SPON1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0036066 protein O-linked fucosylation TAS --
genes like me logo Genes that share ontologies with SPON1: view

No data available for SIGNOR curated interactions for SPON1 Gene

Drugs & Compounds for SPON1 Gene

(1) Additional Compounds for SPON1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPON1: view

Transcripts for SPON1 Gene

mRNA/cDNA for SPON1 Gene

Unigene Clusters for SPON1 Gene

Spondin 1, extracellular matrix protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPON1 Gene

No ASD Table

Relevant External Links for SPON1 Gene

GeneLoc Exon Structure for
SPON1
ECgene alternative splicing isoforms for
SPON1

Expression for SPON1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPON1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPON1 Gene

This gene is overexpressed in Vitreous humor (33.9) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPON1 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPON1 Gene:

SPON1

SOURCE GeneReport for Unigene cluster for SPON1 Gene:

Hs.643864

mRNA Expression by UniProt/SwissProt for SPON1 Gene:

Q9HCB6-SPON1_HUMAN
Tissue specificity: Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.
genes like me logo Genes that share expression patterns with SPON1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPON1 Gene

Orthologs for SPON1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPON1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPON1 34
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia SPON1 34
  • 92.81 (n)
cow
(Bos Taurus)
Mammalia SPON1 34
  • 92.61 (n)
mouse
(Mus musculus)
Mammalia Spon1 34 16
  • 89.63 (n)
rat
(Rattus norvegicus)
Mammalia Spon1 34
  • 89.43 (n)
chicken
(Gallus gallus)
Aves SPON1 34
  • 78.56 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia spon1 34
  • 77.15 (n)
African clawed frog
(Xenopus laevis)
Amphibia spon1-A 34
zebrafish
(Danio rerio)
Actinopterygii spon1a 34
  • 70.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17739 36 34
  • 48.49 (n)
fat-spondin 36
  • 32 (a)
CG30046 36
  • 31 (a)
CG30203 36
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012307 34
  • 42.77 (n)
worm
(Caenorhabditis elegans)
Secernentea F10E7.4 36
  • 27 (a)
Species where no ortholog for SPON1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPON1 Gene

ENSEMBL:
Gene Tree for SPON1 (if available)
TreeFam:
Gene Tree for SPON1 (if available)

Paralogs for SPON1 Gene

Paralogs for SPON1 Gene

genes like me logo Genes that share paralogs with SPON1: view

Variants for SPON1 Gene

Sequence variations from dbSNP and Humsavar for SPON1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000002516 -- 14,007,656(+) CAATC(A/G)AGTTG intron-variant
rs1000004728 -- 14,138,992(+) TGCCC(A/G)TGCTG intron-variant
rs1000041105 -- 14,188,281(+) AGATG(G/T)TTATA intron-variant
rs1000042459 -- 13,963,272(+) CCCTT(A/C)TGTCC intron-variant
rs1000045510 -- 14,227,844(+) AATTA(A/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPON1 Gene

Variant ID Type Subtype PubMed ID
dgv324e212 CNV loss 25503493
esv1173943 CNV deletion 17803354
esv1763444 CNV insertion 17803354
esv2597158 CNV deletion 19546169
esv2668036 CNV deletion 23128226
esv29123 CNV loss 19812545
esv3625418 CNV loss 21293372
nsv1070011 CNV deletion 25765185
nsv1070434 CNV deletion 25765185
nsv478941 CNV novel sequence insertion 20440878
nsv951310 CNV deletion 24416366

Relevant External Links for SPON1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPON1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPON1 Gene

Disorders for SPON1 Gene

Relevant External Links for SPON1

Genetic Association Database (GAD)
SPON1
Human Genome Epidemiology (HuGE) Navigator
SPON1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPON1

No disorders were found for SPON1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPON1 Gene

Publications for SPON1 Gene

  1. The crystal structure of the heparin-binding reelin-N domain of f- spondin. (PMID: 18602404) Tan K. … Wang J.H. (J. Mol. Biol. 2008) 3 4 22 64
  2. Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary. (PMID: 11368520) Miyamoto K. … Minegishi T. (Arch. Biochem. Biophys. 2001) 3 4 22 64
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  4. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S. … Arnett D.K. (Pharmacogenet. Genomics 2012) 3 46 64
  5. The structure of the CaA^+-binding, glycosylated F-spondin domain of F-spondin - A C2-domain variant in an extracellular matrix protein. (PMID: 21569239) Tan K. … Lawler J. (BMC Struct. Biol. 2011) 3 4 64

Products for SPON1 Gene

Sources for SPON1 Gene

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