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Aliases for SPON1 Gene

Aliases for SPON1 Gene

  • Spondin 1 2 3
  • Spondin 1, (F-Spondin) Extracellular Matrix Protein 2 3
  • Vascular Smooth Muscle Cell Growth-Promoting Factor 3 4
  • Spondin 1, Extracellular Matrix Protein 3 5
  • F-Spondin 3 4
  • VSGP/F-Spondin 3
  • KIAA0762 4
  • VSGP 4

External Ids for SPON1 Gene

Previous GeneCards Identifiers for SPON1 Gene

  • GC11P015256
  • GC11P014734
  • GC11P014023
  • GC11P013948
  • GC11P013663

Summaries for SPON1 Gene

GeneCards Summary for SPON1 Gene

SPON1 (Spondin 1) is a Protein Coding gene. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification. An important paralog of this gene is THSD7A.

UniProtKB/Swiss-Prot for SPON1 Gene

  • Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.

Gene Wiki entry for SPON1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPON1 Gene

Genomics for SPON1 Gene

Regulatory Elements for SPON1 Gene

Genomic Location for SPON1 Gene

13,962,637 bp from pter
14,268,133 bp from pter
305,497 bases
Plus strand

Genomic View for SPON1 Gene

Genes around SPON1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPON1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPON1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPON1 Gene

Proteins for SPON1 Gene

  • Protein details for SPON1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K6W5
    • O94862
    • Q8NCD7
    • Q8WUR5

    Protein attributes for SPON1 Gene

    807 amino acids
    Molecular mass:
    90973 Da
    Quaternary structure:
    • Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP.

    Three dimensional structures from OCA and Proteopedia for SPON1 Gene

neXtProt entry for SPON1 Gene

Proteomics data for SPON1 Gene at MOPED

Post-translational modifications for SPON1 Gene

  • Glycosylation at Thr 192, Asn 214, Trp 448, Trp 451, Trp 507, Trp 510, Trp 564, Trp 620, Trp 623, Trp 674, and Asn 681
  • Modification sites at PhosphoSitePlus

Other Protein References for SPON1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for SPON1 (F-Spondin/SPON1)

No data available for DME Specific Peptides for SPON1 Gene

Domains & Families for SPON1 Gene

Suggested Antigen Peptide Sequences for SPON1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 reelin domain.
  • Contains 1 reelin domain.
  • Contains 1 spondin domain.
  • Contains 6 TSP type-1 domains.
genes like me logo Genes that share domains with SPON1: view

No data available for Gene Families for SPON1 Gene

Function for SPON1 Gene

Molecular function for SPON1 Gene

GENATLAS Biochemistry:
spondin 1 (f-spondin) extracellular matrix protein
UniProtKB/Swiss-Prot Function:
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Major factor for vascular smooth muscle cell.
genes like me logo Genes that share phenotypes with SPON1: view

Animal Models for SPON1 Gene

MGI Knock Outs for SPON1:

Animal Model Products

miRNA for SPON1 Gene

miRTarBase miRNAs that target SPON1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPON1 Gene

Localization for SPON1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPON1 Gene

Secreted, extracellular space, extracellular matrix.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for SPON1 Gene

Pathways & Interactions for SPON1 Gene

genes like me logo Genes that share pathways with SPON1: view

Interacting Proteins for SPON1 Gene

Gene Ontology (GO) - Biological Process for SPON1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with SPON1: view

No data available for SIGNOR curated interactions for SPON1 Gene

Drugs & Compounds for SPON1 Gene

(1) Additional Compounds for SPON1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPON1: view

Transcripts for SPON1 Gene

mRNA/cDNA for SPON1 Gene

Unigene Clusters for SPON1 Gene

Spondin 1, extracellular matrix protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPON1 Gene

No ASD Table

Relevant External Links for SPON1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPON1 Gene

mRNA expression in normal human tissues for SPON1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SPON1 Gene

This gene is overexpressed in Vitreous humor (33.9) and Heart (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SPON1 Gene

SOURCE GeneReport for Unigene cluster for SPON1 Gene Hs.643864

mRNA Expression by UniProt/SwissProt for SPON1 Gene

Tissue specificity: Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen.
genes like me logo Genes that share expression patterns with SPON1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SPON1 Gene

Orthologs for SPON1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPON1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPON1 35
  • 92.61 (n)
  • 97.52 (a)
(Canis familiaris)
Mammalia SPON1 35
  • 92.81 (n)
  • 98.27 (a)
(Mus musculus)
Mammalia Spon1 35
  • 89.63 (n)
  • 96.28 (a)
Spon1 16
(Pan troglodytes)
Mammalia SPON1 35
  • 99.63 (n)
  • 99.75 (a)
(Rattus norvegicus)
Mammalia Spon1 35
  • 89.43 (n)
  • 96.78 (a)
(Gallus gallus)
Aves SPON1 35
  • 78.56 (n)
  • 89.22 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spon1 35
  • 77.15 (n)
  • 86.01 (a)
African clawed frog
(Xenopus laevis)
Amphibia spon1-A 35
(Danio rerio)
Actinopterygii spon1a 35
  • 70.79 (n)
  • 79.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17739 37
  • 25 (a)
CG30046 37
  • 31 (a)
CG30203 37
  • 31 (a)
fat-spondin 37
  • 32 (a)
CG17739 35
  • 48.49 (n)
  • 38.53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012307 35
  • 42.77 (n)
  • 30.77 (a)
(Caenorhabditis elegans)
Secernentea F10E7.4 37
  • 27 (a)
Species with no ortholog for SPON1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPON1 Gene

Gene Tree for SPON1 (if available)
Gene Tree for SPON1 (if available)

Paralogs for SPON1 Gene

Paralogs for SPON1 Gene

genes like me logo Genes that share paralogs with SPON1: view

Variants for SPON1 Gene

Sequence variations from dbSNP and Humsavar for SPON1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs8964 -- 14,267,031(+) TTCTT(C/T)TTTTA utr-variant-3-prime
rs11238 -- 14,266,582(+) TAGAC(G/T)TTCAA utr-variant-3-prime
rs11369 -- 14,266,550(+) TGCCT(A/G)AATTT utr-variant-3-prime
rs11565 -- 14,267,107(+) ACTAC(A/G)AATTT utr-variant-3-prime
rs12152 -- 14,267,664(+) AACAT(G/T)ACTCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPON1 Gene

Variant ID Type Subtype PubMed ID
esv2668036 CNV Deletion 23128226
nsv897004 CNV Loss 21882294
esv2597158 CNV Deletion 19546169
esv1173943 CNV Deletion 17803354
esv1763444 CNV Insertion 17803354
esv29123 CNV Loss 19812545

Relevant External Links for SPON1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for SPON1 Gene

Disorders for SPON1 Gene

Relevant External Links for SPON1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPON1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPON1 Gene

Publications for SPON1 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation. (PMID: 18780763) Attur M.G. … Abramson S.B. (FASEB J. 2009) 3 23
  3. The crystal structure of the heparin-binding reelin-N domain of f- spondin. (PMID: 18602404) Tan K. … Wang J.H. (J. Mol. Biol. 2008) 3 23
  4. Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells. (PMID: 16965763) Kitagawa M. … Takata T. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. VSGP/F-spondin: a new ovarian cancer marker. (PMID: 16103746) Pyle-Chenault R.A. … Xu J. (Tumour Biol. 2005) 3 23

Products for SPON1 Gene

Sources for SPON1 Gene

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