Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPON1 Gene

protein-coding   GIFtS: 56
GCID: GC11P013940

Spondin 1, Extracellular Matrix Protein

(Previous names: spondin 1, (f-spondin) extracellular matrix protein)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spondin 1, Extracellular Matrix Protein1 2     spondin-12
Spondin 1, (F-Spondin) Extracellular Matrix Protein1 2     F-spondin3
Vascular Smooth Muscle Cell Growth-Promoting Factor2 3     KIAA07623
VSGP/F-spondin2     VSGP3
f-spondin2     

External Ids:    HGNC: 112521   Entrez Gene: 104182   Ensembl: ENSG000001522687   OMIM: 6049895   UniProtKB: Q9HCB63   

Export aliases for SPON1 gene to outside databases

Previous GC identifers: GC11P015256 GC11P014734 GC11P014023 GC11P013948 GC11P013663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPON1 Gene: 
SPON1 (spondin 1, extracellular matrix protein) is a protein-coding gene. Diseases associated with SPON1 include peters plus syndrome, and sleep apnea, and among its related super-pathways are Rac1 Pathway and Ras Pathway. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: SPON1_HUMAN, Q9HCB6
Function: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the
outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and
the PNS (By similarity). Major factor for vascular smooth muscle cell

Gene Wiki entry for SPON1 (Spondin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPON1 gene promoter:
         RP58   AML1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Tal-1beta   LCR-F1   POU3F2   E47   C/EBPalpha   SRY   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPON1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPON1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPON1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.2   Ensembl cytogenetic band:  11p15.2   HGNC cytogenetic band: 11p15.2

SPON1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPON1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P013940:  view genomic region     (about GC identifiers)

Start:
13,983,914 bp from pter      End:
14,289,656 bp from pter
Size:
305,743 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPON1_HUMAN, Q9HCB6 (See protein sequence)
Recommended Name: Spondin-1 precursor  
Size: 807 amino acids; 90973 Da
Subunit: Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP (By
similarity)
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
4 PDB 3D structures from and Proteopedia for SPON1:
2ZOT (3D)        2ZOU (3D)        3COO (3D)        3Q13 (3D)    
Secondary accessions: A8K6W5 O94862 Q8NCD7 Q8WUR5

Explore the universe of human proteins at neXtProt for SPON1: NX_Q9HCB6

Explore proteomics data for SPON1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HCB6

  • SPON1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPON1 Protein Expression
    REFSEQ proteins: NP_006099.2  
    Human Recombinant Protein Products for SPON1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SPON1 (F-Spondin/SPON1)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SPON1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SPON1
    GenScript Custom Purified and Recombinant Proteins Services for SPON1
    Novus Biologicals SPON1 Protein
    Novus Biologicals SPON1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPON1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA--
    GO:0031012colocalizes with extracellular matrix ISS--

    SPON1 for ontologies           About GeneDecksing



    SPON1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SPON1 (F-Spondin/SPON1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPON1
    GenScript Custom Superior Antibodies Services for SPON1
    Novus Biologicals SPON1 Antibodies
    Abcam antibodies for SPON1
    Cloud-Clone Corp. Antibodies for SPON1 
    ThermoFisher Antibodies for SPON1
    LSBio Antibodies in human, mouse, rat for SPON1 

    Assay Products for SPON1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPON1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPON1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPON1 
    Cloud-Clone Corp. CLIAs for SPON1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000884 Thrombospondin_1_rpt
     IPR009465 Spondin_N
     IPR002861 Reeler_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCB6

    ProtoNet protein and cluster: Q9HCB6

    3 Blocks protein domains:
    IPB002861 Reeler region
    IPB008085 Thrombospondin type 1 repeat signature
    IPB009465 Spondin


    UniProtKB/Swiss-Prot: SPON1_HUMAN, Q9HCB6
    Similarity: Contains 1 reelin domain
    Similarity: Contains 1 spondin domain
    Similarity: Contains 6 TSP type-1 domains


    SPON1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPON1_HUMAN, Q9HCB6
    Function: Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the
    outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and
    the PNS (By similarity). Major factor for vascular smooth muscle cell

         Genatlas biochemistry entry for SPON1:
    spondin 1 (f-spondin) extracellular matrix protein

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14983046
         
    SPON1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPON1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPON1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPON1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPON1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPON1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SPON1 (see all 22):
    hsa-miR-4311 hsa-miR-4307 hsa-miR-218-1* hsa-miR-513c hsa-miR-624 hsa-miR-3190 hsa-miR-570 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSPON1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPON1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPON1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPON1
    Sirion Biotech Customized adenovirus for overexpression of SPON1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SPON1 (see all 7)
    OriGene ORF clones in mouse, rat for SPON1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPON1 (NM_006108)
    Sino Biological Human cDNA Clone for SPON1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPON1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPON1
    Sirion Biotech Customized lentivirus for stable overexpression of SPON1 
                         Customized lentivirus expression plasmids for stable overexpression of SPON1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPON1
    Search LifeMap BioReagents cell lines for SPON1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPON1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPON1 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    2GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    3Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    5/60 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SPON1 (see all 60)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPON1

    5 Interacting proteins for SPON1 (Q9HCB61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP05067-41EBI-2431846,EBI-302641 I2D: score=2 
    YIPF5Q969M33I2D: score=2 
    APLP1P516933I2D: score=1 
    APLP2Q064813I2D: score=1 
    --Q9WMX22MINT-7049881
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--

    SPON1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPON1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPON1

    1 Novoseek inferred chemical compound relationship for SPON1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vegf 27.9 4 11473366 (1), 12173346 (1), 17984117 (1)

    Search CenterWatch for drugs/clinical trials and news about SPON1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPON1 gene: 
    NM_006108.3  

    Unigene Cluster for SPON1:

    Spondin 1, extracellular matrix protein
    Hs.643864  [show with all ESTs]
    Unigene Representative Sequence: NM_006108
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533633 ENST00000526298 ENST00000310358(uc001mle.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPON1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate SPON1 (see all 22):
    hsa-miR-4311 hsa-miR-4307 hsa-miR-218-1* hsa-miR-513c hsa-miR-624 hsa-miR-3190 hsa-miR-570 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidSPON1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPON1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPON1
    Clone
    Products:
         
    OriGene clones in human, mouse for SPON1 (see all 7)
    OriGene ORF clones in mouse, rat for SPON1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPON1 (NM_006108)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPON1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPON1
    Sirion Biotech Customized lentivirus for stable overexpression of SPON1 
                         Customized lentivirus expression plasmids for stable overexpression of SPON1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SPON1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPON1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPON1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPON1

    Additional mRNA sequence: 

    AB018305.2 AB051390.1 AK001584.1 AK074803.1 AK291780.1 BC019825.1 BC041974.1 BC136513.1 
    BC136563.1 

    7 DOTS entries:

    DT.87017050  DT.91949150  DT.120698756  DT.92433194  DT.120698737  DT.91728592  DT.92433184 

    24/248 AceView cDNA sequences (see all 248):

    AI567994 BM970741 AW152432 BX439110 BM677750 AI632649 AA581107 BE049402 
    BC019825 BM474366 BM725316 BM671036 AW572585 AW197421 AI424944 AI632660 
    N39444 BE315203 AI800087 AK001584 AA055340 AU130615 AI700043 AB018305 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPON1 expression in normal human tissues (normalized intensities)      SPON1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCTTGTTG
    SPON1 Expression
    About this image


    SPON1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Fibroblast
             Human periodontal ligament Fibroblasts (HPLF)   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Eye (Sensory Organs)    fully expand to see all 3 entries
             Human corneal endothelial cells
             Human Keratocyte (HK)   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             N2/LSB/S/F8/CHIR-induced cells ( Generation of midbrain dopaminergic, forebrain and...
     
     Dermis (Uncategorized)    fully expand to see all 3 entries
             Human Dermal Fibroblasts-adult (HDF-a)   
             hair follicle bulge   

    See SPON1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPON1

    SOURCE GeneReport for Unigene cluster: Hs.643864

    UniProtKB/Swiss-Prot: SPON1_HUMAN, Q9HCB6
    Tissue specificity: Highest expression in lung, lower expression in brain, heart, kidney, liver and testis, and
    lowest expression in pancreas, skeletal muscle and ovary. Not expressed in spleen

        SABiosciences Custom PCR Arrays for SPON1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SPON1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPON1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPON1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPON1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPON1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPON1 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spon11 , 5 spondin 1, (f-spondin) extracellular matrix protein1, 5 89.63(n)1
    96.28(a)1
      7 (59.25 cM)5
    2337441  NM_145584.21  NP_663559.11 
     1137659985 
    chicken
    (Gallus gallus)
    Aves SPON11 spondin 1, extracellular matrix protein 78.14(n)
    88.24(a)
      395657  NM_204851.1  NP_990182.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia spon1-A2 spondin 1, (f-spondin) extracellular matrix protein 77.9(n)    L09123.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spon1a2 spondin 1a 76.65(n)   58027  AB006086.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fat-spondin3
    CG177391
    CG177391 32(a)
    (best of 4)3
    48.39(n)1
    38.54(a)1
      363331  NM_136913.21  NP_610757.11 


    ENSEMBL Gene Tree for SPON1 (if available)
    TreeFam Gene Tree for SPON1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1303 SNPs in SPON1 are shown (see all 1303)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456058911,2
    C--13983841(+) CATCTA/GTAAAG 1 -- us2k10--------
    rs717566871,2
    C--13984256(+) CTTGG-/GCTCA 
            
    CTCAG
    1 -- ut510--------
    rs1414828151,2
    C--13984734(+) CGGTCC/GCCGGA 1 -- int10--------
    rs50227761,2
    H--13988811(+) GCCTTC/TTGGAT 1 -- int14Minor allele frequency- T:0.00NS EA 420
    rs61442231,2
    C--13990783(+) AAAAA-/A/AA/AA
    AA
    /AAAAAA
    TTAGC
    2 -- int1 cds11NA 2
    rs724693221,2
    C--13991028(+) ATAAA-/AGAGGAA 1 -- int10--------
    rs1472895981,2
    C--13991563(+) GGCCCA/GAATCA 1 -- int10--------
    rs1117291431,2
    C--13994486(+) TTCCA-/TCTCTCT 1 -- int11Minor allele frequency- TC:0.50CSA 2
    rs1404478541,2
    C--13994503(+) CTCTCG/TGTCCC 1 -- int10--------
    rs1448662941,2
    C--13997011(+) AAAGAG/TGCAGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SPON1 (13983914 - 14233914 bp, first 250kb of SPON1)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SPON1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2597158CNV Deletion19546169
    esv1173943CNV Deletion17803354
    esv2668036CNV Deletion23128226
    esv1763444CNV Insertion17803354
    esv29123CNV Loss19812545
    nsv897004CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPON1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPON1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604989    OMIM disorders: --

    16 diseases for SPON1:    About MalaCards
    peters plus syndrome    sleep apnea    congenital disorder of glycosylation    hypoxia
    osteoarthritis    periodontitis    glioblastoma    gastric cancer
    hypertension    alzheimer's disease    ovarian cancer    endotheliitis
    adenocarcinoma    pancreatitis    neuronitis    breast cancer


    SPON1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SPON1
    Human Genome Epidemiology (HuGE) Navigator: SPON1 (1 document)

    Export disorders for SPON1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPON1 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with SPON1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (1998)
    2. Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary. (PubMed id 11368520)1, 2, 9 Miyamoto K.... Minegishi T. (2001)
    3. The crystal structure of the heparin-binding reelin-N domain of f- spondin. (PubMed id 18602404)1, 2, 9 Tan K.... Wang J.H. (2008)
    4. A genome-wide association study of inflammatory biomar ker changes in response to fenofibrate treatment in the Genetics of Lipid Loweri ng Drug and Diet Network. (PubMed id 22228203)1, 4 Aslibekyan S....Arnett D.K. (2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. C-mannosylation and O-fucosylation of thrombospondin type 1 repeats. (PubMed id 12096136)1, 2 Gonzalez de Peredo A.... Hofsteenge J. (2002)
    9. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    10. F-spondin, a neuroregulatory protein, is up-regulated in osteoarthritis and regulates cartilage metabolism via TGF-beta activation. (PubMed id 18780763)1, 9 Attur M.G....Abramson S.B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10418 HGNC: 11252 AceView: SPON1 Ensembl:ENSG00000152268 euGenes: HUgn10418
    ECgene: SPON1 H-InvDB: SPON1

    (According to HUGE)
    About This Section
    HUGE: KIAA0762

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPON1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPON1 gene:
    Search GeneIP for patents involving SPON1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SPON1 (F-Spondin/SPON1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for SPON1 (F-Spondin/SPON1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPON1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SPON1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SPON1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPON1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SPON1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPON1   OriGene Custom Protein Services for SPON1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPON1
     QIAGEN SeqTarget long-range PCR primers for resequencing SPON1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPON1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPON1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPON1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPON1
     GenScript Custom Purified and Recombinant Proteins Services for SPON1 GenScript cDNA clones with any tag delivered in your preferred vector for SPON1
     GenScript Custom Assay Services for SPON1 GenScript Custom Superior Antibodies Services for SPON1
     GenScript Custom overexpressing Cell Line Services for SPON1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SPON1 promoter
     Search Chromatin IP Primers for SPON1
     RT2 qPCR Primer Assay in human, mouse, rat SPON1
     GNC Network for SPON1
     SABiosciences PCR Arrays including human, mouse, rat SPON1
     Search Tocris compounds for SPON1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for SPON1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPON1 antibodies
     SPON1 proteins
     SPON1 lysates
     Antibodies for SPON1
     See all of Abcam's Antibodies, Kits and Proteins for SPON1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SPON1
     Antibodies for SPON1
     ELISAs for SPON1
     CLIAs for SPON1
     Search LifeMap BioReagents cell lines for SPON1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPON1
     SwitchGear 3'UTR luciferase reporter plasmids for SPON1
     SwitchGear Promoter luciferase reporter plasmids for SPON1
     ThermoFisher Antibodies for SPON1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPON1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPON1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPON1
    Customized:
     lentivirus for stable overexpression of SPON1
     lentivirus expression plasmids for stable overexpression of SPON1
     adenovirus for overexpression of SPON1
     LSBio Antibodies in human, mouse, rat for SPON1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPON1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4