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SPOCK3 Gene

protein-coding   GIFtS: 53
GCID: GC04M167654

Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican)
31 2
TICN32 3
HSAJ14542
TES-32
testican-32
SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 33

External Ids:    HGNC: 135651   Entrez Gene: 508592   Ensembl: ENSG000001961047   OMIM: 6079895   UniProtKB: Q9BQ163   

Export aliases for SPOCK3 gene to outside databases

Previous GC identifers: GC04M168064 GC04M168238 GC04M168350 GC04M168029 GC04M167891 GC04M163410


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPOCK3 Gene:
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin
type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the
activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SPOCK3 Gene:
SPOCK3 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3) is a protein-coding gene. Diseases associated with SPOCK3 include adult t-cell leukemia, and t-cell leukemia. GO annotations related to this gene include metalloendopeptidase inhibitor activity and calcium ion binding. An important paralog of this gene is SPOCK1.

UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16
Function: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix
metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPOCK3 gene promoter:
         Egr-3   LHX3b/Lhx3b   NCX/Ncx   FOXD1   E4BP4   Ik-3   HNF-1A   HNF-1   LHX3a/Lhx3a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPOCK3 promoter sequence
   Search Chromatin IP Primers for SPOCK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPOCK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

SPOCK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOCK3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M167654:  view genomic region     (about GC identifiers)

Start:
167,654,535 bp from pter      End:
168,155,947 bp from pter
Size:
501,413 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16 (See protein sequence)
Recommended Name: Testican-3 precursor  
Size: 436 amino acids; 49429 Da
Secondary accessions: B2R7M7 B3KR67 B4DGK5 B4DHB4 B4DHV3 B4DI46 E7EP61 F5H099 O75705 Q6UW53
Q96Q26
Alternative splicing: 9 isoforms:  Q9BQ16-3   Q9BQ16-1   Q9BQ16-2   Q9BQ16-4   Q9BQ16-5   Q9BQ16-6   Q9BQ16-7   Q9BQ16-8   
Q9BQ16-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPOCK3: NX_Q9BQ16

Explore proteomics data for SPOCK3 at MOPED

Post-translational modifications: 

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides (By similarity)1
  • Glycosylation2 at Ser384, Ser389
  • Modification sites at PhosphoSitePlus

  • See SPOCK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001035249.1  NP_001191281.1  NP_001191282.1  NP_001191283.1  NP_001191284.1  NP_001191285.1  NP_001191287.1  NP_001238896.1  
    NP_058646.2  

    ENSEMBL proteins: 
     ENSP00000349677   ENSP00000350153   ENSP00000425570   ENSP00000423421   ENSP00000420920  
     ENSP00000426716   ENSP00000423606   ENSP00000425712   ENSP00000426318   ENSP00000425502  
     ENSP00000424677   ENSP00000424980   ENSP00000422170   ENSP00000426177   ENSP00000423176  
     ENSP00000425859   ENSP00000424674   ENSP00000420928   ENSP00000422336   ENSP00000423367  
     ENSP00000426995   ENSP00000424168   ENSP00000425407   ENSP00000445430   ENSP00000438142  
     ENSP00000411344   ENSP00000441396   ENSP00000444789  

    SPOCK3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SPOCK3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SPOCK3
    GenScript Custom Purified and Recombinant Proteins Services for SPOCK3
    Novus Biologicals SPOCK3 Proteins
    Novus Biologicals SPOCK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SPOCK3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SPOCK3 (Testican 3/SPOCK3)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPOCK3
    Novus Biologicals SPOCK3 Antibodies
    Abcam antibodies for SPOCK3
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for SPOCK3
    LSBio Antibodies in human, mouse, rat for SPOCK3

    SPOCK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPOCK3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPOCK3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR011992 EF-hand-dom_pair
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR000716 Thyroglobulin_1

    Graphical View of Domain Structure for InterPro Entry Q9BQ16

    ProtoNet protein and cluster: Q9BQ16

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    SPOCK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TICN3_HUMAN, Q9BQ16
    Function: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix
    metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding IEA--
    GO:0008191metalloendopeptidase inhibitor activity IEA--
         
    SPOCK3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Spock3):
     normal 

    SPOCK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Spock3tm1Htmm for SPOCK3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPOCK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPOCK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPOCK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPOCK3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SPOCK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPOCK3 (see all 24):
    hsa-miR-548j hsa-miR-548i hsa-miR-15a hsa-miR-424 hsa-miR-124 hsa-miR-548x hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPOCK3
    Predesigned siRNA for gene silencing in human, mouse, rat SPOCK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPOCK3

    Clone
    Products:
         
    OriGene clones in human, mouse for SPOCK3 (see all 11)
    OriGene ORF clones in mouse, rat for SPOCK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 10): SPOCK3 (NM_001204355)
    Sino Biological Human cDNA Clone for SPOCK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SPOCK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPOCK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TICN3_HUMAN, Q9BQ16: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA11751414
    GO:0031012extracellular matrix IDA11751414

    SPOCK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPOCK3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SPOCK3 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPOCK3
    Interactions:

        Search GeneGlobe Interaction Network for SPOCK3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for SPOCK3 (Q9BQ162, 3 ENSP000003501534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP14P502813, ENSP000003082084I2D: score=2 STRING: ENSP00000308208
    MMP3P082543, ENSP000002998554I2D: score=2 STRING: ENSP00000299855
    SPOCK2Q925633, ENSP000003211084I2D: score=2 STRING: ENSP00000321108
    CREB3O438893I2D: score=1 
    --Q9WMX22MINT-7047918
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0010951negative regulation of endopeptidase activity IDA11751414
    GO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA--

    SPOCK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPOCK3 (TICN3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPOCK3 gene (10 alternative transcripts): 
    NM_001040159.1  NM_001204352.1  NM_001204353.1  NM_001204354.1  NM_001204355.1  NM_001204356.1  NM_001204358.1  NM_001251967.1  
    NM_016950.2  NM_001204359.1  

    Unigene Cluster for SPOCK3:

    Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
    Hs.481133  [show with all ESTs]
    Unigene Representative Sequence: NM_001204352
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000357154(uc021xuf.1 uc011cjq.1 uc011cjr.1 uc003iri.1 uc011cjs.1 uc003irj.1 uc011cjt.1 uc011cjp.2 uc011cju.1 uc011cjv.1)
    ENST00000357545 ENST00000504953 ENST00000511531 ENST00000506886 ENST00000507137
    ENST00000510741 ENST00000502330 ENST00000511905 ENST00000512681 ENST00000511269
    ENST00000507370 ENST00000502821 ENST00000505187 ENST00000512648(uc003irk.4)
    ENST00000510403 ENST00000515143 ENST00000511226
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPOCK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPOCK3 (see all 24):
    hsa-miR-548j hsa-miR-548i hsa-miR-15a hsa-miR-424 hsa-miR-124 hsa-miR-548x hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPOCK3
    Predesigned siRNA for gene silencing in human, mouse, rat SPOCK3
    Clone
    Products:
         
    OriGene clones in human, mouse for SPOCK3 (see all 11)
    OriGene ORF clones in mouse, rat for SPOCK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 10): SPOCK3 (NM_001204355)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SPOCK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPOCK3
      QuantiTect SYBR Green Assays in human, mouse, rat SPOCK3
      QuantiFast Probe-based Assays in human, mouse, rat SPOCK3

    Additional mRNA sequence: 

    AB056866.1 AJ001454.1 AK091078.1 AK294293.1 AK294346.1 AK294637.1 AK295015.1 AK295281.1 
    AK295407.1 AK295414.1 AK296291.1 AK313042.1 AY358973.1 BC000460.2 BC003017.1 BC013983.2 

    10 DOTS entries:

    DT.40112755  DT.75113992  DT.100835778  DT.121268883  DT.121268866  DT.97858294  DT.121268802  DT.121268805 
    DT.95079316  DT.95079317 

    Selected AceView cDNA sequences (see all 82):

    BP361814 BX463580 AA861657 AL120454 AW250783 N47945 AA084138 BC003017 
    BC000460 CR607485 BF222625 AW023630 BG701497 AB056866 BI757179 BG191023 
    BI549875 BI600087 AK091078 BM505167 AY358973 BI597096 NM_016950 AV725167 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPOCK3 expression in normal human tissues (normalized intensities)      SPOCK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPOCK3 Expression
    About this image


    SPOCK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mesenchymal Condensate Cells Zeugopod
             Zeugopod Epiphyseal End
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Mesenchymal Condensate Cells Zeugopod
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    SPOCK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPOCK3 Protein Expression

    Genevestigator expression for SPOCK3

    SOURCE GeneReport for Unigene cluster: Hs.481133

    UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16
    Tissue specificity: Expressed in brain

        Custom PCR Arrays for SPOCK3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPOCK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPOCK3
    QuantiTect SYBR Green Assays in human, mouse, rat SPOCK3
    QuantiFast Probe-based Assays in human, mouse, rat SPOCK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPOCK3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spock31 , 5 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more1, 5 89.72(n)1
    90.98(a)1
      8 (31.97 cM)5
    729021  NM_001252620.11  NP_001239549.11 
     629510095 
    chicken
    (Gallus gallus)
    Aves SPOCK31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 83.04(n)
    87.59(a)
      422425  XM_420393.4  XP_420393.2 
    lizard
    (Anolis carolinensis)
    Reptilia SPOCK36
    sparc/osteonectin, cwcv and kazal-like domains pro...
    85(a)
    1 ↔ 1
    GL343317.1(1030579-1129453)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia spock31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 76.07(n)
    80.86(a)
      100124745  NM_001102726.1  NP_001096196.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.129412 Transcribed sequence with weak similarity to protein more 75.16(n)    CK357112.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138306
    --
    19(a)
    1 → many
    3R(18896371-18938437)
    worm
    (Caenorhabditis elegans)
    Secernentea C54E4.21 C54E4.2 52.08(n)
    43.75(a)
      177010  NM_001027927.3  NP_001023098.1 


    ENSEMBL Gene Tree for SPOCK3 (if available)
    TreeFam Gene Tree for SPOCK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPOCK3 gene
    SPOCK12  SPOCK22  
    4 SIMAP similar genes for SPOCK3 using alignment to 12 protein entries:     TICN3_HUMAN (see all proteins):
    tmp_locus_3    SPOCK1    SPOCK2    WUGSC

    SPOCK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPOCK3 (see all 9568)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840805051,2
    --167654043(+) GCTTTA/CTTGGG 8 -- ds50010--------
    rs287135091,2
    F--167654077(+) AAAAGC/TCTAAC 8 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs175976431,2
    C,F--167654104(+) TTGTTA/GCTTTA 8 -- ds50014Minor allele frequency- G:0.03NA 262
    rs284623061,2
    F--167654120(+) ATTTGT/CTAAAC 8 -- ds50012Minor allele frequency- C:0.33CSA 3
    rs1455670841,2
    --167654157(+) TTCCCA/CACCAG 8 -- ds50010--------
    rs176960221,2
    C,F--167654212(+) TCAAAA/GTGCTG 8 -- ds50014Minor allele frequency- G:0.01NA EA 260
    rs284517851,2
    F--167654223(+) TTGCTA/GTAGAA 8 -- ds50013Minor allele frequency- G:0.06CSA WA 122
    rs119421441,2
    C,F,H--167654337(+) ATAAAC/TCACCA 8 -- ds50016Minor allele frequency- T:0.43WA NA CSA EA 364
    rs100213431,2
    C,F,A--167654397(+) AAGAGC/G/TGCTAA 8 -- ds50018NA WA CSA EA 368
    rs339553431,2
    C--167654414(+) ATTCT-/AAAATT 8 -- ds50011Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for SPOCK3 (167654535 - 167904535 bp, first 250kb of SPOCK3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPOCK3 (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3863CNV Deletion18987735
    esv2728699CNV Deletion23290073
    nsv436416CNV Deletion17901297
    dgv97n16CNV Deletion17901297
    nsv820858CNV Deletion20802225
    esv2673273CNV Deletion23128226
    esv2675353CNV Deletion23128226
    esv2432618CNV Deletion19546169
    esv1005052CNV Deletion20482838
    dgv990e199CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPOCK3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607989    OMIM disorders: --

    7 diseases for SPOCK3:    About MalaCards
    adult t-cell leukemia    t-cell leukemia    smallpox    leukemia
    retinitis    obesity    endotheliitis


    SPOCK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPOCK3
    Human Genome Epidemiology (HuGE) Navigator: SPOCK3 (2 documents)

    Export disorders for SPOCK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPOCK3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with SPOCK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of membrane-type 1 matrix metalloproteinase (MMP)- mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. (PubMed id 11751414)1, 2, 3 Nakada M.... Sato H. (Cancer Res. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    7. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    8. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    9. Testican 3 expression in adult T-cell leukemia. (PubMed id 19144404)1 Kamioka M....Sugiura T. (Leuk. Res. 2009)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50859 HGNC: 13565 AceView: SPOCK3 Ensembl:ENSG00000196104 euGenes: HUgn50859
    ECgene: SPOCK3 H-InvDB: SPOCK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPOCK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPOCK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPOCK3 gene:
    Search GeneIP for patents involving SPOCK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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