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Aliases & Descriptions for SPOCK3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases HSAJ1454 2 TES-3 2 TICN3 3 testican-3 1
Descriptions SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3 3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 2 testican 3 2
Search outside databases for aliases for SPOCK3 genePrevious GC identifers: GC04M168064 GC04M168238 GC04M168350 GC04M168029
Summaries for SPOCK3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for SPOCK3 : Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, arecomponents of the extracellular matrix. SPOCK3 encodes a member of a novel Ca(2+)-bindingproteoglycan family.[supplied by OMIM] UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16 Function : May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrixmetalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion
Genomic Location for SPOCK3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the SPOCK3 gene Entrez Gene cytogenetic band: 4q32.3 Ensembl cytogenetic band: 4q32.3 HGNC cytogenetic band: 4q32.3 SPOCK3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure
GeneLoc location for GC04M167891:
(about GC identifiers )
Start:
167,891,110 bp from pter
End:
168,392,316 bp from pter
Size:
501,207 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000004.10 NT_022792.17 Proteins for SPOCK3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16 (See
protein sequence )Recommended Name: Testican-3 precursor Size : 436 amino acids; 49429 Da
Subcellular location : Secreted, extracellular space, extracellular matrix
Secondary accessions : B2R7M7 O75705 Q6UW53 Q96Q26Alternative splicing : 3 isoforms : Q9BQ16-3 Q9BQ16-1 Q9BQ16-2
Post-translational modifications:
Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides (By similarity)1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001035249.1 NP_058646.2 ENSEMBL proteins: ENSP00000349677 ENSP00000350153 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA -- GO:0005578 proteinaceous extracellular matrix
IEA --
About this table Antibodies for SPOCK3: Assays for SPOCK3:
Protein
Domains/ Families for SPOCK3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9BQ16 ProtoNet protein and cluster: Q9BQ16
2 Blocks protein families : IPB000716 Thyroglobulin type-1 IPB011497 Protease inhibitor UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16 Similarity : Contains 1 Kazal-like domainSimilarity : Contains 1 thyroglobulin type-1 domain
Gene Function for SPOCK3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016950 Applied Biosystems Silencer ® siRNAs for SPOCK3 Sigma-Aldrich siRNA for SPOCK3 Sigma-Aldrich shRNA Panels and shRNA for SPOCK3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040159                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040159                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001040159  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016950 UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16 Function : May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrixmetalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion
3 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004857 enzyme inhibitor activity
IEA -- GO:0005509 calcium ion binding
IEA -- GO:0008191 metalloendopeptidase inhibitor activity
IEA --
About this table
Pathways & Interactions for SPOCK3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Interacting proteins for SPOCK3 (ENSP00000349677 3 Q9BQ16 2 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007165 signal transduction
IEA --
About this table
Drugs & Compounds for SPOCK3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for SPOCK3
Transcripts for SPOCK3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016950 Sigma-Aldrich siRNA for SPOCK3 Sigma-Aldrich shRNA Panels and shRNA for SPOCK3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001040159 NM_016950
REFSEQ mRNAs for SPOCK3 gene (2 alternative transcripts): NM_001040159.1 NM_016950.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001040159 NM_016950
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040159                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001040159                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001040159  
Additional cDNA sequence: AB056866.1 AJ001454.1 AK091078.1 AK294293.1 AK294346.1 AK294637.1 AK295015.1 AK295281.1 AK295407.1 AK295414.1 AK296291.1 AK313042.1 AY358973.1 BC000460.2 BC003017.1 BC013983.2 CR607485.1
10 DOTS entries : DT.40112755 DT.75113992 DT.100835778 DT.121268883 DT.121268866 DT.97858294 DT.121268802 DT.121268805 DT.95079316 DT.95079317
24/82 AceView cDNA sequences (see all 82
):AA861657 AA084138 CR607485 N47945 BP361814 BX463580 AW250783 BC000460 AL120454 BF222625 BC003017 BI552050 AI038716 BI600087 BI548904 BG705231 BI602818 AW023630 BF309481 BI603782 BC013983 BM505167 BP350070 BI597096
highest scoring ESTs for SPOCK3 :AJ001454 AI808090 AB056866 AK091078 AY358973 BC000460 BC003017 BC013983 BE267201 BE267395
Unigene Cluster for SPOCK3: Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 Hs.481133 [show with all ESTs ] Unigene Representative Sequence: NM_016950 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000357154
ENST00000357545
Expression for SPOCK3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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SPOCK3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for SPOCK3 1 / 2 / 3
9 probe-sets matching SPOCK3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.481133 Expression variation in blood from EXPOLDB for SPOCK3
UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16 Tissue specificity : Expressed in brain
Orthologs for SPOCK3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for SPOCK3 gene from 5 species
About this table Species with no ortholog for SPOCK3 ENSEMBL Gene Tree for SPOCK3 Paralogs for SPOCK3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for SPOCK3 gene SPOCK1 2 SPOCK2 2
SNPs/Variants for SPOCK3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for SPOCK3 (up to first 250kb)
Disorders & Mutations for SPOCK3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607989
Medical News for SPOCK3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for SPOCK3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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7 PubMed articles for SPOCK3 gene : Suppression of membrane-type 1 matrix metalloproteinase (MMP)- mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. (PubMed id 11751414) 2, 3, 4 Nakada M.... Sato H. (2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3, 4 Clark H.F....Gray A. (2003) Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. (PubMed id 12810672) 3 Nakada M....Sato H. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 4 Aoki H.... Hino O. (2000)
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Genome Databases showing SPOCK3
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing SPOCK3
(According to HUGE )
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Specialized Databases showing SPOCK3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for SPOCK3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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