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Aliases for SPOCK3 Gene

Aliases for SPOCK3 Gene

  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 3 2 3 5
  • TICN3 3 4
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 3 4
  • HSAJ1454 3
  • TES-3 3

External Ids for SPOCK3 Gene

Previous GeneCards Identifiers for SPOCK3 Gene

  • GC04M168064
  • GC04M168238
  • GC04M168350
  • GC04M168029
  • GC04M167891
  • GC04M167654
  • GC04M163410

Summaries for SPOCK3 Gene

Entrez Gene Summary for SPOCK3 Gene

  • This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK3 Gene

SPOCK3 (Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 3) is a Protein Coding gene. Diseases associated with SPOCK3 include adult t-cell leukemia. Among its related pathways are ERK Signaling and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is SPOCK2.

UniProtKB/Swiss-Prot for SPOCK3 Gene

  • May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK3 Gene

Genomics for SPOCK3 Gene

Regulatory Elements for SPOCK3 Gene

Promoters for SPOCK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPOCK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPOCK3 Gene

Chromosome:
4
Start:
166,733,384 bp from pter
End:
167,234,796 bp from pter
Size:
501,413 bases
Orientation:
Minus strand

Genomic View for SPOCK3 Gene

Genes around SPOCK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK3 Gene

Proteins for SPOCK3 Gene

  • Protein details for SPOCK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ16-TICN3_HUMAN
    Recommended name:
    Testican-3
    Protein Accession:
    Q9BQ16
    Secondary Accessions:
    • B2R7M7
    • B3KR67
    • B4DGK5
    • B4DHB4
    • B4DHV3
    • B4DI46
    • B4DJY3
    • E7EP61
    • F5H099
    • O75705
    • Q6UW53
    • Q96Q26

    Protein attributes for SPOCK3 Gene

    Size:
    436 amino acids
    Molecular mass:
    49429 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAG58995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK3 Gene

neXtProt entry for SPOCK3 Gene

Proteomics data for SPOCK3 Gene at MOPED

Post-translational modifications for SPOCK3 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at Ser 384 and Ser 389
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for SPOCK3 (Testican 3/SPOCK3)

No data available for DME Specific Peptides for SPOCK3 Gene

Domains & Families for SPOCK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BQ16

UniProtKB/Swiss-Prot:

TICN3_HUMAN :
  • Contains 1 Kazal-like domain.
Domain:
  • Contains 1 Kazal-like domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with SPOCK3: view

No data available for Gene Families for SPOCK3 Gene

Function for SPOCK3 Gene

Molecular function for SPOCK3 Gene

UniProtKB/Swiss-Prot Function:
May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.
genes like me logo Genes that share phenotypes with SPOCK3: view

Animal Models for SPOCK3 Gene

MGI Knock Outs for SPOCK3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK3

miRNA for SPOCK3 Gene

miRTarBase miRNAs that target SPOCK3

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPOCK3 Gene

Localization for SPOCK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPOCK3 Gene COMPARTMENTS Subcellular localization image for SPOCK3 gene
Compartment Confidence
extracellular 5
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for SPOCK3 Gene

Pathways & Interactions for SPOCK3 Gene

genes like me logo Genes that share pathways with SPOCK3: view

Interacting Proteins for SPOCK3 Gene

Gene Ontology (GO) - Biological Process for SPOCK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SPOCK3: view

No data available for SIGNOR curated interactions for SPOCK3 Gene

Drugs & Compounds for SPOCK3 Gene

No Compound Related Data Available

Transcripts for SPOCK3 Gene

Unigene Clusters for SPOCK3 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK3 Gene

No ASD Table

Relevant External Links for SPOCK3 Gene

GeneLoc Exon Structure for
SPOCK3
ECgene alternative splicing isoforms for
SPOCK3

Expression for SPOCK3 Gene

mRNA expression in normal human tissues for SPOCK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x8.5), Brain - Substantia nigra (x6.0), Brain - Putamen (basal ganglia) (x5.7), Brain - Hippocampus (x5.2), Brain - Caudate (basal ganglia) (x5.0), Brain - Nucleus accumbens (basal ganglia) (x4.3), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for SPOCK3 Gene

This gene is overexpressed in Vitreous humor (58.2) and Frontal cortex (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPOCK3 Gene



SOURCE GeneReport for Unigene cluster for SPOCK3 Gene Hs.481133

mRNA Expression by UniProt/SwissProt for SPOCK3 Gene

Q9BQ16-TICN3_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with SPOCK3: view

Protein tissue co-expression partners for SPOCK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SPOCK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SPOCK3 35
  • 91.1 (n)
  • 91.53 (a)
SPOCK3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spock3 35
  • 89.72 (n)
  • 90.98 (a)
Spock3 16
Spock3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPOCK3 35
  • 99.39 (n)
  • 99.31 (a)
SPOCK3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spock3 35
  • 89.39 (n)
  • 89.72 (a)
oppossum
(Monodelphis domestica)
Mammalia SPOCK3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPOCK3 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPOCK3 35
  • 83.04 (n)
  • 87.59 (a)
SPOCK3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPOCK3 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spock3 35
  • 76.07 (n)
  • 80.86 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12941 35
spock3 35
  • 66.57 (n)
  • 64.18 (a)
spock3 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13830 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C54E4.2 35
  • 52.08 (n)
  • 43.75 (a)
C54E4.2 36
  • 32 (a)
OneToMany
Species with no ortholog for SPOCK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOCK3 Gene

ENSEMBL:
Gene Tree for SPOCK3 (if available)
TreeFam:
Gene Tree for SPOCK3 (if available)

Paralogs for SPOCK3 Gene

Paralogs for SPOCK3 Gene

genes like me logo Genes that share paralogs with SPOCK3: view

Variants for SPOCK3 Gene

Sequence variations from dbSNP and Humsavar for SPOCK3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs9685645 - 167,000,374(+) ACTAA(C/G/T)GCAGA intron-variant, reference, missense
rs765749 -- 167,034,602(-) GCTAT(A/G)GTTTT intron-variant
rs921856 -- 166,824,065(-) TGACC(C/T)GTCTT intron-variant
rs921857 -- 166,824,050(-) ATGTC(A/T)CTCAG intron-variant
rs815211 -- 167,116,526(-) ataca(C/T)atacg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK3 Gene

Variant ID Type Subtype PubMed ID
nsv880770 CNV Loss 21882294
nsv4593 CNV Loss 18451855
nsv822822 CNV Gain 20364138
esv2673273 CNV Deletion 23128226
nsv508329 CNV Loss 20534489
dgv97n16 CNV Deletion 17901297
esv2619228 CNV Loss 19546169
esv2510827 CNV Deletion 19546169
esv1005052 CNV Deletion 20482838
esv2120481 CNV Deletion 18987734
nsv513177 CNV Loss 21212237
esv2728699 CNV Deletion 23290073
esv3863 CNV Deletion 18987735
esv2664916 CNV Deletion 23128226
nsv499072 CNV Loss 21111241
esv8954 CNV Loss 19470904
nsv528717 CNV Loss 19592680
nsv822823 CNV Loss 20364138
esv2728700 CNV Deletion 23290073
esv269876 CNV Insertion 20981092
esv29919 CNV Gain 19812545
nsv436877 CNV Insertion 17901297
dgv1712e1 CNV Complex 17122850
nsv436416 CNV Deletion 17901297
esv2675353 CNV Deletion 23128226
nsv881605 CNV Loss 21882294
esv24658 CNV Gain 19812545
nsv293099 CNV Insertion 16902084
nsv881679 CNV Gain 21882294
dgv990e199 CNV Deletion 23128226
esv2432618 CNV Deletion 19546169
nsv436442 CNV Deletion 17901297
nsv820858 CNV Deletion 20802225
esv2728701 CNV Deletion 23290073
esv1003468 CNV Gain 20482838
esv28141 CNV Gain+Loss 19812545
esv2540605 CNV Loss 19546169
esv2475463 OTHER Inversion 19546169
nsv880344 CNV Gain 21882294

Variation tolerance for SPOCK3 Gene

Residual Variation Intolerance Score: 55.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPOCK3 Gene

HapMap Linkage Disequilibrium report
SPOCK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK3 Gene

Disorders for SPOCK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPOCK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
adult t-cell leukemia
  • adult t-cell leukemia/lymphoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPOCK3

Genetic Association Database (GAD)
SPOCK3
Human Genome Epidemiology (HuGE) Navigator
SPOCK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPOCK3
genes like me logo Genes that share disorders with SPOCK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPOCK3 Gene

Publications for SPOCK3 Gene

  1. Suppression of membrane-type 1 matrix metalloproteinase (MMP)- mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. (PMID: 11751414) Nakada M. … Sato H. (Cancer Res. 2001) 2 3 4 67
  2. SPOCK3, a risk gene for adult ADHD and personality disorders. (PMID: 24292267) Weber H. … Reif A. (Eur Arch Psychiatry Clin Neurosci 2014) 3
  3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for SPOCK3 Gene

Sources for SPOCK3 Gene

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