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Aliases for SPOCK3 Gene

Aliases for SPOCK3 Gene

  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 3 2 3
  • TICN3 3 4
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 3 4
  • Testican-3 3
  • HSAJ1454 3
  • TES-3 3

External Ids for SPOCK3 Gene

Previous GeneCards Identifiers for SPOCK3 Gene

  • GC04M168064
  • GC04M168238
  • GC04M168350
  • GC04M168029
  • GC04M167891
  • GC04M167654
  • GC04M163410

Summaries for SPOCK3 Gene

Entrez Gene Summary for SPOCK3 Gene

  • This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK3 Gene

SPOCK3 (Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 3) is a Protein Coding gene. Diseases associated with SPOCK3 include adult t-cell leukemia and t-cell leukemia. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding and metalloendopeptidase inhibitor activity. An important paralog of this gene is SPOCK2.

UniProtKB/Swiss-Prot for SPOCK3 Gene

  • May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK3 Gene

Genomics for SPOCK3 Gene

Regulatory Elements for SPOCK3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPOCK3 Gene

166,733,384 bp from pter
167,234,796 bp from pter
501,413 bases
Minus strand

Genomic View for SPOCK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPOCK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK3 Gene

Proteins for SPOCK3 Gene

  • Protein details for SPOCK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R7M7
    • B3KR67
    • B4DGK5
    • B4DHB4
    • B4DHV3
    • B4DI46
    • B4DJY3
    • E7EP61
    • F5H099
    • O75705
    • Q6UW53
    • Q96Q26

    Protein attributes for SPOCK3 Gene

    436 amino acids
    Molecular mass:
    49429 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAG58995.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK3 Gene

neXtProt entry for SPOCK3 Gene

Proteomics data for SPOCK3 Gene at MOPED

Post-translational modifications for SPOCK3 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at Ser384 and Ser389
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SPOCK3 Gene

Domains for SPOCK3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9BQ16
  • Contains 1 Kazal-like domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with SPOCK3: view

No data available for Gene Families for SPOCK3 Gene

Function for SPOCK3 Gene

Molecular function for SPOCK3 Gene

UniProtKB/Swiss-Prot Function: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion

Gene Ontology (GO) - Molecular Function for SPOCK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0005539 glycosaminoglycan binding IEA --
GO:0008191 metalloendopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SPOCK3: view

Phenotypes for SPOCK3 Gene

MGI mutant phenotypes for SPOCK3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SPOCK3: view

Animal Models for SPOCK3 Gene

MGI Knock Outs for SPOCK3:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPOCK3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SPOCK3 Gene

Localization for SPOCK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for SPOCK3 Gene COMPARTMENTS Subcellular localization image for SPOCK3 gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SPOCK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 11751414
GO:0031012 extracellular matrix IDA 11751414
genes like me logo Genes that share ontologies with SPOCK3: view

Pathways for SPOCK3 Gene

genes like me logo Genes that share pathways with SPOCK3: view

Pathways by source for SPOCK3 Gene

Interacting Proteins for SPOCK3 Gene

Gene Ontology (GO) - Biological Process for SPOCK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0010951 negative regulation of endopeptidase activity IEA --
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
genes like me logo Genes that share ontologies with SPOCK3: view

Transcripts for SPOCK3 Gene

Unigene Clusters for SPOCK3 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPOCK3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPOCK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK3 Gene

No ASD Table

Relevant External Links for SPOCK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPOCK3 Gene

mRNA expression in normal human tissues for SPOCK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK3 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (8.5), Brain - Substantia nigra (6.0), Brain - Putamen (basal ganglia) (5.7), Brain - Hippocampus (5.2), Brain - Caudate (basal ganglia) (5.0), Brain - Nucleus accumbens (basal ganglia) (4.3), and Brain - Hypothalamus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPOCK3 Gene

SOURCE GeneReport for Unigene cluster for SPOCK3 Gene Hs.481133

mRNA Expression by UniProt/SwissProt for SPOCK3 Gene

Tissue specificity: Expressed in brain
genes like me logo Genes that share expressions with SPOCK3: view

In Situ Assay Products

Orthologs for SPOCK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPOCK3 35
  • 99.39 (n)
  • 99.31 (a)
  • 99 (a)
(Canis familiaris)
Mammalia SPOCK3 35
  • 91.1 (n)
  • 91.53 (a)
  • 92 (a)
(Mus musculus)
Mammalia Spock3 35
  • 89.72 (n)
  • 90.98 (a)
Spock3 16
Spock3 36
  • 89 (a)
(Monodelphis domestica)
Mammalia SPOCK3 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia SPOCK3 36
  • 65 (a)
(Rattus norvegicus)
Mammalia Spock3 35
  • 89.39 (n)
  • 89.72 (a)
(Gallus gallus)
Aves SPOCK3 35
  • 83.04 (n)
  • 87.59 (a)
  • 86 (a)
(Anolis carolinensis)
Reptilia SPOCK3 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spock3 35
  • 76.07 (n)
  • 80.86 (a)
(Danio rerio)
Actinopterygii Dr.12941 35
spock3 35
  • 66.57 (n)
  • 64.18 (a)
spock3 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13830 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C54E4.2 35
  • 52.08 (n)
  • 43.75 (a)
C54E4.2 36
  • 32 (a)
Species with no ortholog for SPOCK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOCK3 Gene

Gene Tree for SPOCK3 (if available)
Gene Tree for SPOCK3 (if available)

Paralogs for SPOCK3 Gene

Paralogs for SPOCK3 Gene

genes like me logo Genes that share paralogs with SPOCK3: view

Variants for SPOCK3 Gene

Sequence variations from dbSNP and Humsavar for SPOCK3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs714067 -- 166,996,417(+) TATAC(A/C)AAAAC intron-variant
rs728112 -- 166,996,381(-) ATGCT(C/G/T)CCTTG intron-variant
rs745244 -- 166,773,692(+) CTTTA(C/T)GGGTG intron-variant
rs765749 -- 167,034,602(-) GCTAT(A/G)GTTTT intron-variant
rs815211 -- 167,116,526(-) ataca(C/T)atacg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK3 Gene

Variant ID Type Subtype PubMed ID
nsv880770 CNV Loss 21882294
nsv4593 CNV Loss 18451855
nsv822822 CNV Gain 20364138
esv2673273 CNV Deletion 23128226
nsv508329 CNV Loss 20534489
dgv97n16 CNV Deletion 17901297
esv2619228 CNV Loss 19546169
esv2510827 CNV Deletion 19546169
esv1005052 CNV Deletion 20482838
esv2120481 CNV Deletion 18987734
nsv513177 CNV Loss 21212237
esv2728699 CNV Deletion 23290073
esv3863 CNV Deletion 18987735
esv2664916 CNV Deletion 23128226
nsv499072 CNV Loss 21111241
esv8954 CNV Loss 19470904
nsv528717 CNV Loss 19592680
nsv822823 CNV Loss 20364138
esv2728700 CNV Deletion 23290073
esv269876 CNV Insertion 20981092
esv29919 CNV Gain 19812545
nsv436877 CNV Insertion 17901297
dgv1712e1 CNV Complex 17122850
nsv436416 CNV Deletion 17901297
esv2675353 CNV Deletion 23128226
nsv881605 CNV Loss 21882294
esv24658 CNV Gain 19812545
nsv293099 CNV Insertion 16902084
nsv881679 CNV Gain 21882294
dgv990e199 CNV Deletion 23128226
esv2432618 CNV Deletion 19546169
nsv436442 CNV Deletion 17901297
nsv820858 CNV Deletion 20802225
esv2728701 CNV Deletion 23290073
esv1003468 CNV Gain 20482838
esv28141 CNV Gain+Loss 19812545
esv2540605 CNV Loss 19546169
esv2475463 OTHER Inversion 19546169
nsv880344 CNV Gain 21882294

Relevant External Links for SPOCK3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK3 Gene

Disorders for SPOCK3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SPOCK3 Gene including...

Search for SPOCK3 Gene in MalaCards »

Relevant External Links for SPOCK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPOCK3: view

No data available for UniProtKB/Swiss-Prot for SPOCK3 Gene

Publications for SPOCK3 Gene

  1. Suppression of membrane-type 1 matrix metalloproteinase (MMP)- mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. (PMID: 11751414) Nakada M. … Sato H. (Cancer Res. 2001) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for SPOCK3 Gene

Sources for SPOCK3 Gene

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