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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPOCK3 Gene

protein-coding   GIFtS: 50
GCID: GC04M167654

sparc/osteonectin, cwcv and kazal-like domains proteoglycan...
 Explore 3 diseases affiliated with
SPOCK3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPOCK3    

Aliases
for SPOCK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 31 2
Testican-31
TICN32 3
HSAJ14542
TES-32
SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 33

External Ids:    HGNC: 135651   Entrez Gene: 508592   Ensembl: ENSG000001961047   OMIM: 6079895   UniProtKB: Q9BQ163   

Export aliases for SPOCK3 gene to outside databases

Previous GC identifers: GC04M168064 GC04M168238 GC04M168350 GC04M168029 GC04M167891 GC04M163410


Summaries
for SPOCK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPOCK3:
This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1
and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of
membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have
been observed for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16
Function: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2
(MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion




Genomic Views
for SPOCK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPOCK3 gene promoter:
         Egr-3   LHX3b/Lhx3b   NCX/Ncx   FOXD1   E4BP4   Ik-3   HNF-1A   HNF-1   LHX3a/Lhx3a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPOCK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPOCK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOCK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

SPOCK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOCK3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M167654:  view genomic region     (about GC identifiers)

Start:
 167,654,535 bp from pter      End:
 168,155,947 bp from pter
Size:
 501,413 bases      Orientation:
 minus strand

Proteins
for SPOCK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16 (See protein sequence)
Recommended Name: Testican-3 precursor  
Size: 436 amino acids; 49429 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: B2R7M7 B3KR67 B4DGK5 B4DHB4 B4DHV3 F5H099 O75705 Q6UW53 Q96Q26
Alternative splicing: 6 isoforms:  Q9BQ16-3   Q9BQ16-1   Q9BQ16-2   Q9BQ16-4   Q9BQ16-5   Q9BQ16-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPOCK3: NX_Q9BQ16

Post-translational modifications:

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BQ16

    • SPOCK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (9 alternative transcripts): 
    NP_001035249.1  NP_001191281.1  NP_001191282.1  NP_001191283.1  NP_001191284.1  NP_001191285.1  NP_001191287.1  NP_001238896.1  
    NP_058646.2  

    ENSEMBL proteins: 
     ENSP00000349677   ENSP00000350153   ENSP00000425570   ENSP00000420920   ENSP00000423421  
     ENSP00000423606   ENSP00000426716   ENSP00000425712   ENSP00000426318   ENSP00000425502  
     ENSP00000424677   ENSP00000424980   ENSP00000422170   ENSP00000426177   ENSP00000423176  
     ENSP00000425859   ENSP00000424674   ENSP00000420928   ENSP00000422336   ENSP00000423367  
     ENSP00000426995   ENSP00000424168   ENSP00000425407   ENSP00000445430   ENSP00000438142  
     ENSP00000411344   ENSP00000441396   ENSP00000444789  

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    OriGene Protein Over-expression Lysate: SPOCK3
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    Novus Biologicals SPOCK3 Proteins
    Novus Biologicals SPOCK3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA11751414
    GO:0031012extracellular matrix IDA11751414


    SPOCK3 for ontologies           About GeneDecksing



    SPOCK3 Antibody Products: 
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    Novus Biologicals SPOCK3 Antibodies
    Search for Antibodies for SPOCK3 at Abcam  
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for SPOCK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPOCK3 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR011992 EF-hand-like_dom
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR000716 Thyroglobulin_1
     IPR011497 Kazal-type_dom

    Graphical View of Domain Structure for InterPro Entry Q9BQ16

    ProtoNet protein and cluster: Q9BQ16

    2 Blocks protein families:
    IPB000716 Thyroglobulin type-1
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Function
    for SPOCK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16
    Function: May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2
    (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SPOCK3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK3
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK3 (see all 24):
    hsa-miR-548j hsa-miR-548i hsa-miR-15a hsa-miR-424 hsa-miR-124 hsa-miR-548x hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SPOCK3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPOCK3 (see all 7)
    OriGene shRNA RFP: SPOCK3
    OriGene siRNA: SPOCK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCK3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPOCK3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPOCK3 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 10): SPOCK3 (NM_001204355)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SPOCK3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005539glycosaminoglycan binding IEA--
    GO:0008191metalloendopeptidase inhibitor activity IEA--


    SPOCK3 for ontologies           About GeneDecksing



    Pathways & Interactions
    for SPOCK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Integrin Pathway
    		Integrin Pathway1.00
    		UPA-UPAR Pathway0.51
    		FAK1 Signaling0.67
    		Transendothelial Migration of Leukocytes0.38
    		GnRH Signaling0.56
    		Inhibition of Angiogenesis by TSP10.37
    2Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    3PTEN Pathway
    		PTEN Pathway1.00
    		Phospholipase-C Pathway0.56

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SPOCK3 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPOCK3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for SPOCK3 (Q9BQ162, 3 ENSP000003501534) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP14P502813, ENSP000003082084I2D: score=2 STRING: ENSP00000308208
    MMP3P082543, ENSP000002998554I2D: score=2 STRING: ENSP00000299855
    SPOCK2Q925633, ENSP000003211084I2D: score=2 STRING: ENSP00000321108
    CREB3O438893I2D: score=1 
    --Q9WMX22MINT-7047918
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0010951negative regulation of endopeptidase activity IDA11751414
    GO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA--


    SPOCK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPOCK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPOCK3
    Search CenterWatch for drugs/clinical trials and news about SPOCK3 / TICN3 

    Transcripts
    for SPOCK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPOCK3 gene (10 alternative transcripts): 
    NM_001040159.1  NM_001204352.1  NM_001204353.1  NM_001204354.1  NM_001204355.1  NM_001204356.1  NM_001204358.1  NM_001251967.1  
    NM_016950.2  NM_001204359.1  

    Unigene Cluster for SPOCK3:

    Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
    Hs.481133  [show with all ESTs]
    Unigene Representative Sequence: NM_001204352
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000357154(uc021xuf.1 uc011cjq.1 uc011cjr.1 uc003iri.1 uc011cjs.1 uc003irj.1 uc011cjt.1 uc011cjp.2 uc011cju.1 uc011cjv.1)
    ENST00000357545 ENST00000504953 ENST00000506886 ENST00000511531 ENST00000507137
    ENST00000502330 ENST00000510741 ENST00000511905 ENST00000512681 ENST00000511269
    ENST00000507370 ENST00000502821 ENST00000505187 ENST00000512648(uc003irk.4)
    ENST00000510403 ENST00000515143 ENST00000511226

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK3
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK3 (see all 24):
    hsa-miR-548j hsa-miR-548i hsa-miR-15a hsa-miR-424 hsa-miR-124 hsa-miR-548x hsa-miR-548a-5p hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmid: SPOCK3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPOCK3 (see all 7)
    OriGene shRNA RFP: SPOCK3
    OriGene siRNA: SPOCK3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCK3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPOCK3 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPOCK3 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 10): SPOCK3 (NM_001204355)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOCK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOCK3

    Additional cDNA sequence: 

    AB056866.1 AJ001454.1 AK091078.1 AK294293.1 AK294346.1 AK294637.1 AK295015.1 AK295281.1 
    AK295407.1 AK295414.1 AK296291.1 AK313042.1 AY358973.1 BC000460.2 BC003017.1 BC013983.2 

    10 DOTS entries:

    DT.40112755  DT.75113992  DT.100835778  DT.121268883  DT.121268866  DT.97858294  DT.121268802  DT.121268805 
    DT.95079316  DT.95079317 

    24/82 AceView cDNA sequences (see all 82):

    BP361814 BF222625 BC003017 BC000460 AA861657 BX463580 CR607485 AW250783 
    N47945 AA084138 AL120454 BI546451 BE794949 BI603782 BC013983 BM505167 
    BG707851 BI597365 BI602818 BG714340 BG701497 BF309481 BI604024 AV725167 

    GeneLoc Exon Structure


    Expression
    for SPOCK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPOCK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPOCK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbZeugopodMesenchymal Condensate CellsBone, Cartilage
    LimbZeugopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    BoneZeugopod Epiphyseal EndBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPOCK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPOCK3

    SOURCE GeneReport for Unigene cluster: Hs.481133

    UniProtKB/Swiss-Prot: TICN3_HUMAN, Q9BQ16
    Tissue specificity: Expressed in brain

        SABiosciences Custom PCR Arrays for SPOCK3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK3

    Orthologs
    for SPOCK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPOCK3 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SPOCK31 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 83.56(n)
    87.5(a)    		   422425  XM_420393.3  XP_420393.2 
    lizard
    (Anolis carolinensis)    		 Reptilia SPOCK36
    		 --
    		 85(a)
    		 1 ↔ 1
    		 GL343317.1(1032195-1095319)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.129412 Transcribed sequence with weak similarity to protein more 75.16(n)    CK357112.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG138306
    		 --
    		 18(a)
    		 1 → many
    		 3R(18896371-18938437)
    worm
    (Caenorhabditis elegans)    		 Secernentea C54E4.26
    		 Protein C54E4.2, isoform a
    		 32(a)
    		 1 → many
    		 IV(2136895-2146461)


    ENSEMBL Gene Tree for SPOCK3 (if available)
    TreeFam Gene Tree for SPOCK3 (if available) 

    Paralogs
    for SPOCK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPOCK3 gene
    SPOCK12  SPOCK22  
    4 SIMAP similar genes for SPOCK3 using alignment to 14 protein entries:     TICN3_HUMAN (see all proteins):
    tmp_locus_3    SPOCK1    SPOCK2    WUGSC

    SPOCK3 for paralogs           About GeneDecksing



    Genomic Variants
    for SPOCK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 27 variations for SPOCK3
         15/26 CNVs (see all 26): 64017 80562 80561 80563 80560 36223 64016 23152 43623 3525 22712 92527 80565 39402 22948
         1 Inversion: 103358
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPOCK3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPOCK3

    Disorders / Diseases
    for SPOCK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPOCK3 for disorders           About GeneDecksing

    OMIM gene information: 607989    OMIM disorders: --

    3 diseases for SPOCK3:    About MalaCards
    adult t-cell leukemia    t-cell leukemia    leukemia

    Human Genome Epidemiology (HuGE) Navigator: SPOCK3 (2 documents)

    Export disorders for SPOCK3 gene to outside databases

    Publications
    for SPOCK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPOCK3 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with SPOCK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Suppression of membrane-type 1 matrix metalloproteinase (MMP)- mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. (PubMed id 11751414)1, 2, 3 Nakada M.... Sato H. (2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Testican 3 expression in adult T-cell leukemia. (PubMed id 19144404)1 Kamioka M....Sugiura T. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. (PubMed id 12810672)1 Nakada M....Sato H. (2003)

    External Searches for SPOCK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SPOCK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 50859 HGNC: 13565 AceView: SPOCK3 Ensembl:ENSG00000196104 euGenes: HUgn50859
    ECgene: SPOCK3 H-InvDB: SPOCK3

    Other Databases showing SPOCK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPOCK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPOCK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPOCK3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SPOCK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPOCK3 gene:
    Search GeneIP for patents involving SPOCK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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