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Aliases for SPOCK2 Gene

Aliases for SPOCK2 Gene

  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2 2 3 5
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 2 3 4
  • Testican-2 3
  • KIAA0275 4
  • TICN2 4

External Ids for SPOCK2 Gene

Previous GeneCards Identifiers for SPOCK2 Gene

  • GC10M072922
  • GC10M073711
  • GC10M073163
  • GC10M073488
  • GC10M073818
  • GC10M067813

Summaries for SPOCK2 Gene

Entrez Gene Summary for SPOCK2 Gene

  • This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK2 Gene

SPOCK2 (Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2) is a Protein Coding gene. Diseases associated with SPOCK2 include endometriosis of ovary. Among its related pathways are ERK Signaling and Integrin Pathway. GO annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPOCK1.

UniProtKB/Swiss-Prot for SPOCK2 Gene

  • May participate in diverse steps of neurogenesis. Binds calcium.

Gene Wiki entry for SPOCK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK2 Gene

Genomics for SPOCK2 Gene

Regulatory Elements for SPOCK2 Gene

Promoters for SPOCK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPOCK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPOCK2 Gene

Chromosome:
10
Start:
72,059,034 bp from pter
End:
72,089,032 bp from pter
Size:
29,999 bases
Orientation:
Minus strand

Genomic View for SPOCK2 Gene

Genes around SPOCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK2 Gene

Proteins for SPOCK2 Gene

  • Protein details for SPOCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92563-TICN2_HUMAN
    Recommended name:
    Testican-2
    Protein Accession:
    Q92563
    Secondary Accessions:
    • C9J767
    • Q6UW87

    Protein attributes for SPOCK2 Gene

    Size:
    424 amino acids
    Molecular mass:
    46779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13404.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPOCK2 Gene

Proteomics data for SPOCK2 Gene at MOPED

Post-translational modifications for SPOCK2 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at Asn 225, Ser 383, and Ser 388
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK2 Gene

Antibody Products

  • R&D Systems Antibodies for SPOCK2 (Testican 2/SPOCK2)

No data available for DME Specific Peptides for SPOCK2 Gene

Domains & Families for SPOCK2 Gene

Suggested Antigen Peptide Sequences for SPOCK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92563

UniProtKB/Swiss-Prot:

TICN2_HUMAN :
  • Contains 1 Kazal-like domain.
Domain:
  • Contains 1 Kazal-like domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with SPOCK2: view

No data available for Gene Families for SPOCK2 Gene

Function for SPOCK2 Gene

Molecular function for SPOCK2 Gene

UniProtKB/Swiss-Prot Function:
May participate in diverse steps of neurogenesis. Binds calcium.

Gene Ontology (GO) - Molecular Function for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 10386950
genes like me logo Genes that share ontologies with SPOCK2: view
genes like me logo Genes that share phenotypes with SPOCK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPOCK2 Gene

Localization for SPOCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPOCK2 Gene COMPARTMENTS Subcellular localization image for SPOCK2 gene
Compartment Confidence
extracellular 5
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for SPOCK2 Gene

Pathways & Interactions for SPOCK2 Gene

genes like me logo Genes that share pathways with SPOCK2: view

Interacting Proteins for SPOCK2 Gene

Gene Ontology (GO) - Biological Process for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007416 synapse assembly NAS 10386950
genes like me logo Genes that share ontologies with SPOCK2: view

No data available for SIGNOR curated interactions for SPOCK2 Gene

Drugs & Compounds for SPOCK2 Gene

(1) Drugs for SPOCK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SPOCK2: view

Transcripts for SPOCK2 Gene

Unigene Clusters for SPOCK2 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9: -

Relevant External Links for SPOCK2 Gene

GeneLoc Exon Structure for
SPOCK2
ECgene alternative splicing isoforms for
SPOCK2

Expression for SPOCK2 Gene

mRNA expression in normal human tissues for SPOCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK2 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for SPOCK2 Gene

This gene is overexpressed in Testis (39.4) and Amniocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPOCK2 Gene



SOURCE GeneReport for Unigene cluster for SPOCK2 Gene Hs.523009

mRNA Expression by UniProt/SwissProt for SPOCK2 Gene

Q92563-TICN2_HUMAN
Tissue specificity: Highly expressed in brain. Also found in lung and testis.
genes like me logo Genes that share expression patterns with SPOCK2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for SPOCK2 Gene

Orthologs for SPOCK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPOCK2 35
  • 93.45 (n)
  • 96.94 (a)
SPOCK2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPOCK2 35
  • 92.53 (n)
  • 95.52 (a)
SPOCK2 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spock2 35
  • 90.03 (n)
  • 93.35 (a)
Spock2 16
Spock2 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPOCK2 35
  • 99.69 (n)
  • 99.76 (a)
SPOCK2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spock2 35
  • 88.83 (n)
  • 93.86 (a)
oppossum
(Monodelphis domestica)
Mammalia SPOCK2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPOCK2 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPOCK2 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPOCK2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spock2 35
  • 77.69 (n)
  • 83.33 (a)
zebrafish
(Danio rerio)
Actinopterygii spock2 35
  • 70.54 (n)
  • 69.77 (a)
spock2 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13830 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C54E4.2 36
  • 28 (a)
OneToMany
Species with no ortholog for SPOCK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOCK2 Gene

ENSEMBL:
Gene Tree for SPOCK2 (if available)
TreeFam:
Gene Tree for SPOCK2 (if available)

Paralogs for SPOCK2 Gene

Paralogs for SPOCK2 Gene

(5) SIMAP similar genes for SPOCK2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPOCK2: view

Variants for SPOCK2 Gene

Sequence variations from dbSNP and Humsavar for SPOCK2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2306322 - 72,063,097(+) GTCAC(C/T)GCTGC reference, missense
rs3180 -- 72,060,864(+) CAGAC(A/G)GGATG utr-variant-3-prime
rs7307 -- 72,059,175(+) GAGGC(A/G)GGGCG utr-variant-3-prime
rs15256 -- 72,060,790(+) TGGAG(C/T)TAAGT utr-variant-3-prime
rs15562 -- 72,060,820(-) AGTCC(C/T)TCTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPOCK2 Gene

Variant ID Type Subtype PubMed ID
nsv895718 CNV Loss 21882294
nsv7204 OTHER Inversion 18451855
nsv895720 CNV Loss 21882294
esv2738374 CNV Deletion 23290073
esv2667322 CNV Deletion 23128226
esv1328020 CNV Deletion 17803354
nsv515889 CNV Loss 19592680
nsv522541 CNV Loss 19592680

Variation tolerance for SPOCK2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPOCK2 Gene

HapMap Linkage Disequilibrium report
SPOCK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK2 Gene

Disorders for SPOCK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPOCK2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometriosis of ovary
  • ovarian endometriosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPOCK2

Genetic Association Database (GAD)
SPOCK2
Human Genome Epidemiology (HuGE) Navigator
SPOCK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPOCK2
genes like me logo Genes that share disorders with SPOCK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPOCK2 Gene

Publications for SPOCK2 Gene

  1. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. (PMID: 10386950) Vannahme C. … Maurer P. (J. Neurochem. 1999) 2 3 4 67
  2. Genome-wide meta-analyses of smoking behaviors in African Americans. (PMID: 22832964) David S.P. … Furberg H. (Transl Psychiatry 2012) 3
  3. Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia. (PMID: 21836138) Hadchouel A. … Delacourt C. (Am. J. Respir. Crit. Care Med. 2011) 3
  4. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan R.C. … Wallaschofski H. (Hum. Mol. Genet. 2011) 3
  5. Purification and characterization of a recombinant human testican-2 expressed in baculovirus-infected Sf9 insect cells. (PMID: 17950619) Pavsic M. … Lenarcic B. (Protein Expr. Purif. 2008) 3

Products for SPOCK2 Gene

Sources for SPOCK2 Gene

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