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Aliases for SPOCK2 Gene

Aliases for SPOCK2 Gene

  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2 2 3
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 2 3 4
  • KIAA0275 4 6
  • Testican-2 3
  • TICN2 4

External Ids for SPOCK2 Gene

Previous GeneCards Identifiers for SPOCK2 Gene

  • GC10M072922
  • GC10M073711
  • GC10M073163
  • GC10M073488
  • GC10M073818
  • GC10M067813

Summaries for SPOCK2 Gene

Entrez Gene Summary for SPOCK2 Gene

  • This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK2 Gene

SPOCK2 (Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SPOCK1.

UniProtKB/Swiss-Prot for SPOCK2 Gene

  • May participate in diverse steps of neurogenesis. Binds calcium

Gene Wiki entry for SPOCK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK2 Gene

Genomics for SPOCK2 Gene

Regulatory Elements for SPOCK2 Gene

Genomic Location for SPOCK2 Gene

72,059,034 bp from pter
72,089,032 bp from pter
29,999 bases
Minus strand

Genomic View for SPOCK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPOCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK2 Gene

Proteins for SPOCK2 Gene

  • Protein details for SPOCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • C9J767
    • Q6UW87

    Protein attributes for SPOCK2 Gene

    424 amino acids
    Molecular mass:
    46779 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA13404.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK2 Gene


neXtProt entry for SPOCK2 Gene

Proteomics data for SPOCK2 Gene at MOPED

Post-translational modifications for SPOCK2 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at Asn225, Ser383, and Ser388
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK2 Gene

No data available for DME Specific Peptides for SPOCK2 Gene

Domains for SPOCK2 Gene

Suggested Antigen Peptide Sequences for SPOCK2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q92563
  • Contains 1 Kazal-like domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with SPOCK2: view

No data available for Gene Families for SPOCK2 Gene

Function for SPOCK2 Gene

Molecular function for SPOCK2 Gene

UniProtKB/Swiss-Prot Function: May participate in diverse steps of neurogenesis. Binds calcium

Gene Ontology (GO) - Molecular Function for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 10386950
GO:0005515 protein binding --
GO:0005539 glycosaminoglycan binding IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with SPOCK2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPOCK2 Gene

Localization for SPOCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for SPOCK2 Gene COMPARTMENTS Subcellular localization image for SPOCK2 gene
Compartment Confidence
extracellular 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10386950
genes like me logo Genes that share ontologies with SPOCK2: view

Pathways for SPOCK2 Gene

genes like me logo Genes that share pathways with SPOCK2: view

Pathways by source for SPOCK2 Gene

Interacting Proteins for SPOCK2 Gene

Gene Ontology (GO) - Biological Process for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007416 synapse assembly NAS 10386950
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
GO:0030198 extracellular matrix organization NAS 10386950
genes like me logo Genes that share ontologies with SPOCK2: view

Compounds for SPOCK2 Gene

(1) HMDB Compounds for SPOCK2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with SPOCK2: view

Transcripts for SPOCK2 Gene

Unigene Clusters for SPOCK2 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - -
SP2: - -
SP4: -
SP5: - - - - - -
SP7: - - - - - - - - - - - - - - - - - - -
SP9: -

Relevant External Links for SPOCK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPOCK2 Gene

mRNA expression in normal human tissues for SPOCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK2 Gene

This gene is overexpressed in Brain - Cerebellum (5.2) and Brain - Cerebellar Hemisphere (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPOCK2 Gene

SOURCE GeneReport for Unigene cluster for SPOCK2 Gene Hs.523009

mRNA Expression by UniProt/SwissProt for SPOCK2 Gene

Tissue specificity: Highly expressed in brain. Also found in lung and testis.
genes like me logo Genes that share expressions with SPOCK2: view

Orthologs for SPOCK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPOCK2 35
  • 99.69 (n)
  • 99.76 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SPOCK2 35
  • 93.45 (n)
  • 96.94 (a)
  • 97 (a)
(Canis familiaris)
Mammalia SPOCK2 35
  • 92.53 (n)
  • 95.52 (a)
  • 94 (a)
(Mus musculus)
Mammalia Spock2 35
  • 90.03 (n)
  • 93.35 (a)
Spock2 16
Spock2 36
  • 93 (a)
(Monodelphis domestica)
Mammalia SPOCK2 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia SPOCK2 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Spock2 35
  • 88.83 (n)
  • 93.86 (a)
(Gallus gallus)
Aves SPOCK2 36
  • 67 (a)
(Anolis carolinensis)
Reptilia SPOCK2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spock2 35
  • 77.69 (n)
  • 83.33 (a)
(Danio rerio)
Actinopterygii spock2 35
  • 70.54 (n)
  • 69.77 (a)
spock2 36
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13830 36
  • 19 (a)
(Caenorhabditis elegans)
Secernentea C54E4.2 36
  • 28 (a)
Species with no ortholog for SPOCK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOCK2 Gene

Gene Tree for SPOCK2 (if available)
Gene Tree for SPOCK2 (if available)

Paralogs for SPOCK2 Gene

Paralogs for SPOCK2 Gene

Selected SIMAP similar genes for SPOCK2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPOCK2: view

Variants for SPOCK2 Gene

Sequence variations from dbSNP and Humsavar for SPOCK2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3180 -- 72,060,864(+) CAGAC(A/G)GGATG utr-variant-3-prime
rs7307 -- 72,059,175(+) GAGGC(A/G)GGGCG utr-variant-3-prime
rs15256 -- 72,060,790(+) TGGAG(C/T)TAAGT utr-variant-3-prime
rs15562 -- 72,060,820(-) AGTCC(C/T)TCTTG utr-variant-3-prime
rs737080 -- 72,061,153(-) TCTCC(C/T)CAGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SPOCK2 Gene

Variant ID Type Subtype PubMed ID
nsv895718 CNV Loss 21882294
nsv7204 OTHER Inversion 18451855
nsv895720 CNV Loss 21882294
esv2738374 CNV Deletion 23290073
esv2667322 CNV Deletion 23128226
esv1328020 CNV Deletion 17803354
nsv515889 CNV Loss 19592680
nsv522541 CNV Loss 19592680

Relevant External Links for SPOCK2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK2 Gene

Disorders for SPOCK2 Gene

(1) University of Copenhagen DISEASES for SPOCK2 Gene

Relevant External Links for SPOCK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SPOCK2: view

No data available for UniProtKB/Swiss-Prot for SPOCK2 Gene

Publications for SPOCK2 Gene

  1. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. (PMID: 10386950) Vannahme C. … Maurer P. (J. Neurochem. 1999) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PMID: 18398821) Nordgard S.H. … Kristensen V.N. (Genes Chromosomes Cancer 2008) 3 48

Products for SPOCK2 Gene

Sources for SPOCK2 Gene

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