Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPOCK2 Gene

protein-coding   GIFtS: 57
GCID: GC10M073818

Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan...

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican)
21 2
SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 22 3
KIAA02753 5
testican-22
TICN23

External Ids:    HGNC: 135641   Entrez Gene: 98062   Ensembl: ENSG000001077427   OMIM: 6079885   UniProtKB: Q925633   
ORGUL members:         
NONCODE14:n340064      

Export aliases for SPOCK2 gene to outside databases

Previous GC identifers: GC10M072922 GC10M073711 GC10M073163 GC10M073488 GC10M067813


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPOCK2 Gene:
This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The
protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan
attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode
different protein isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SPOCK2 Gene: 
SPOCK2 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with SPOCK2 include endometrioid ovary carcinoma, and bronchopulmonary dysplasia, and among its related super-pathways are FAK1 Signaling and MAPK Signaling. GO annotations related to this gene include extracellular matrix binding and calcium ion binding. An important paralog of this gene is SPOCK1.

UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563
Function: May participate in diverse steps of neurogenesis. Binds calcium

Gene Wiki entry for SPOCK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPOCK2 gene promoter:
         MyoD   RelA   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   SRY   FOXO1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPOCK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPOCK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10pter-q25.3   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

SPOCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOCK2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M073818:  view genomic region     (about GC identifiers)

Start:
73,818,792 bp from pter      End:
73,848,790 bp from pter
Size:
29,999 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563 (See protein sequence)
Recommended Name: Testican-2 precursor  
Size: 424 amino acids; 46779 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (Probable)
Sequence caution: Sequence=BAA13404.2; Type=Erroneous initiation;
Secondary accessions: C9J767 Q6UW87
Alternative splicing: 2 isoforms:  Q92563-1   Q92563-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPOCK2: NX_Q92563

Explore proteomics data for SPOCK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92563

  • SPOCK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPOCK2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001127906.1  NP_001231879.1  NP_055582.1  

    ENSEMBL proteins: 
     ENSP00000362201   ENSP00000321108   ENSP00000439445   ENSP00000397715  

    Human Recombinant Protein Products for SPOCK2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SPOCK2 (Testican 2/SPOCK2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SPOCK2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SPOCK2
    GenScript Custom Purified and Recombinant Proteins Services for SPOCK2
    Novus Biologicals SPOCK2 Protein
    Novus Biologicals SPOCK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS10386950

    SPOCK2 for ontologies           About GeneDecksing



    SPOCK2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SPOCK2 (Testican 2/SPOCK2)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPOCK2
    GenScript Custom Superior Antibodies Services for SPOCK2
    Novus Biologicals SPOCK2 Antibodies
    Abcam antibodies for SPOCK2
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for SPOCK2
    LSBio Antibodies in human, mouse, rat for SPOCK2 

    Assay Products for SPOCK2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPOCK2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPOCK2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR011992 EF-hand-like_dom
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR000716 Thyroglobulin_1

    Graphical View of Domain Structure for InterPro Entry Q92563

    ProtoNet protein and cluster: Q92563

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    SPOCK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TICN2_HUMAN, Q92563
    Function: May participate in diverse steps of neurogenesis. Binds calcium

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA10386950
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding ----
    GO:0050840extracellular matrix binding ----
         
    SPOCK2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPOCK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPOCK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPOCK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPOCK2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK2
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK2 (see all 65):
    hsa-miR-1321 hsa-miR-200a hsa-miR-342-3p hsa-miR-642b hsa-miR-92b hsa-miR-490-5p hsa-miR-491-3p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPOCK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPOCK2
    Sirion Biotech Customized adenovirus for overexpression of SPOCK2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SPOCK2 (see all 11)
    OriGene ORF clones in mouse, rat for SPOCK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPOCK2 (NM_014767)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK2
    Sirion Biotech Customized lentivirus for stable overexpression of SPOCK2 
                         Customized lentivirus expression plasmids for stable overexpression of SPOCK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPOCK2
    Search LifeMap BioReagents cell lines for SPOCK2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPOCK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    Integrin Pathway0.67
    UPA-UPAR Pathway0.56
    FAK1 Signaling0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3PTEN Pathway
    PTEN Pathway0.56
    Phospholipase-C Pathway0.56

    5/13 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SPOCK2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPOCK2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SPOCK2 (Q925633 ENSP000003211084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB3Q9ULL43, ENSP000003553784I2D: score=2 STRING: ENSP00000355378
    SPOCK3Q9BQ163, ENSP000003501534I2D: score=2 STRING: ENSP00000350153
    TESQ9UGI83, ENSP000003509374I2D: score=2 STRING: ENSP00000350937
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0007416synapse assembly NAS10386950
    GO:0010811positive regulation of cell-substrate adhesion ----
    GO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan ----
    GO:0030198extracellular matrix organization NAS10386950

    SPOCK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPOCK2 (TICN2)

    1 HMDB Compound for SPOCK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Search CenterWatch for drugs/clinical trials and news about SPOCK2 / TICN2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPOCK2 gene (3 alternative transcripts): 
    NM_001134434.1  NM_001244950.1  NM_014767.2  

    Unigene Cluster for SPOCK2:

    Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
    Hs.523009  [show with all ESTs]
    Unigene Representative Sequence: NM_001244950
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373109(uc001jso.2) ENST00000463279 ENST00000469121 ENST00000460053
    ENST00000495888 ENST00000483699 ENST00000317376(uc001jsp.3 uc010qjs.2)
    ENST00000536168 ENST00000412663(uc010qjt.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK2
    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK2 (see all 65):
    hsa-miR-1321 hsa-miR-200a hsa-miR-342-3p hsa-miR-642b hsa-miR-92b hsa-miR-490-5p hsa-miR-491-3p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPOCK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCK2
    Clone
    Products:
         
    OriGene clones in human, mouse for SPOCK2 (see all 11)
    OriGene ORF clones in mouse, rat for SPOCK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPOCK2 (NM_014767)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK2
    Sirion Biotech Customized lentivirus for stable overexpression of SPOCK2 
                         Customized lentivirus expression plasmids for stable overexpression of SPOCK2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPOCK2
    OriGene qSTAR qPCR primer pairs in human, mouse for SPOCK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPOCK2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOCK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOCK2

    Additional mRNA sequence: 

    AJ001453.1 AK294008.1 AK307091.1 AY358921.1 BC023558.2 BC127951.1 BC127952.1 D87465.1 

    9 DOTS entries:

    DT.454958  DT.100812935  DT.40280876  DT.75140939  DT.100044569  DT.86854644  DT.95212809  DT.91759985 
    DT.95301941 

    24/300 AceView cDNA sequences (see all 300):

    BQ631856 BM994170 BQ002304 AA323277 BM805735 BQ719060 T33218 BE855481 
    Z38828 BE395340 AA323721 AI470995 T33219 Z42668 AI356317 BG152477 
    BQ129334 BM903809 AA910596 AW085823 BX281500 T33680 AI423403 BQ640081 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK2 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                                                -     -     -                                                         
    SP2:                                                                                      -     -                                                         
    SP3:                                                                                                                                                      
    SP4:                                                                                            -                                                         
    SP5:                                            -     -     -                       -     -     -                                                         


    ECgene alternative splicing isoforms for SPOCK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPOCK2 expression in normal human tissues (normalized intensities)      SPOCK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAAAGGAA
    SPOCK2 Expression
    About this image


    SPOCK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Endothelial Cells Blood Brain Barrier
             Thalamus
             postcentral gyrus   
     
     Blood (Cardiovascular System)    fully expand to see all 6 entries
             Double Positive Thymocytes Thymus
             Peripheral blood Pan-T Cells   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Renal Vesicle
             Human Renal Mesangial Cells (HRMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood Brain Barrier (Nervous System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier

    See SPOCK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPOCK2

    SOURCE GeneReport for Unigene cluster: Hs.523009

    UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563
    Tissue specificity: Highly expressed in brain. Also found in lung and testis

        SABiosciences Custom PCR Arrays for SPOCK2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPOCK2
    OriGene qSTAR qPCR primer pairs in human, mouse for SPOCK2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPOCK2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOCK2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOCK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPOCK2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spock21 , 5 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more1, 5 89.76(n)1
    93.85(a)1
      10 (29.69 cM)5
    942141  NM_052994.21  NP_443720.11 
     601062195 
    chicken
    (Gallus gallus)
    Aves SPOCK26
    sparc/osteonectin, cwcv and kazal-like domains pro...
    68(a)
    1 ↔ 1
    6(11067606-11069056)
    lizard
    (Anolis carolinensis)
    Reptilia SPOCK26
    sparc/osteonectin, cwcv and kazal-like domains pro...
    84(a)
    1 ↔ 1
    3(51363684-51493625)
    zebrafish
    (Danio rerio)
    Actinopterygii spock21 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 71.68(n)
    71.36(a)
      100320541  XM_002664184.2  XP_002664230.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138306
    --
    18(a)
    1 → many
    3R(18896371-18938437)
    worm
    (Caenorhabditis elegans)
    Secernentea C54E4.26
    Protein C54E4.2, isoform b
    30(a)
    1 → many
    IV(2136895-2146461)


    ENSEMBL Gene Tree for SPOCK2 (if available)
    TreeFam Gene Tree for SPOCK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPOCK2 gene
    SPOCK12  SPOCK32  
    5 SIMAP similar genes for SPOCK2 using alignment to 4 protein entries:     TICN2_HUMAN (see all proteins):
    tmp_locus_3    AGRN    SPOCK3    SPOCK1    WUGSC

    SPOCK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/757 SNPs in SPOCK2 are shown (see all 757)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446636561,2
    --73818293(+) CTAGCC/GGCGCT 2 -- int10--------
    rs1894889531,2
    --73818312(+) TGGTTC/TTACCT 2 -- int10--------
    rs1810398661,2
    --73818343(+) AGAGGC/TGGTTG 2 -- int10--------
    rs79075761,2
    C,F,H--73818346(+) GGTGGT/CTGAAG 2 -- int14Minor allele frequency- C:0.00NS EA 408
    rs1865407651,2
    --73818406(+) GGTGAC/TGGCTG 2 -- int10--------
    rs1897060041,2
    --73818548(+) TCCTAA/GGCTCA 2 -- int10--------
    rs1814863061,2
    C--73818630(+) CACTAC/TGTTGC 2 -- int10--------
    rs1395210591,2
    C--73818641(+) CTAGG-/CCAGTC 2 -- int10--------
    rs1137438171,2
    C,F--73818721(+) ACCACG/ACTCAG 2 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs1859378371,2
    --73818728(+) TCAGCA/CATAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SPOCK2 (73818792 - 73848790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SPOCK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667322CNV Deletion23128226
    esv1328020CNV Deletion17803354
    esv2738374CNV Deletion23290073
    nsv522541CNV Loss19592680
    nsv515889CNV Loss19592680
    nsv895718CNV Loss21882294
    nsv895720CNV Loss21882294
    nsv7204OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPOCK2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPOCK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607988    OMIM disorders: --

    4 diseases for SPOCK2:    About MalaCards
    endometrioid ovary carcinoma    bronchopulmonary dysplasia    alzheimer's disease    breast cancer

    1 disease from the University of Copenhagen DISEASES database for SPOCK2:
    Endometrioid ovary carcinoma

    SPOCK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SPOCK2
    Human Genome Epidemiology (HuGE) Navigator: SPOCK2 (2 documents)

    Export disorders for SPOCK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPOCK2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with SPOCK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. (PubMed id 10386950)1, 2, 3 Vannahme C.... Maurer P. (1999)
    2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PubMed id 21216879)1, 4 Kaplan R.C....Wallaschofski H. (2011)
    3. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PubMed id 18398821)1, 4 Nordgard S.H....Kristensen V.N. (2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T....Nomura N. (1996)
    9. Genome-wide meta-analyses of smoking behaviors in Afri can Americans. (PubMed id 22832964)1 David S.P....Furberg H. (2012)
    10. Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia. (PubMed id 21836138)1 Hadchouel A....Delacourt C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9806 HGNC: 13564 AceView: SPOCK2 Ensembl:ENSG00000107742 euGenes: HUgn9806
    ECgene: SPOCK2 H-InvDB: SPOCK2

    (According to HUGE)
    About This Section
    HUGE: KIAA0275

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPOCK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPOCK2 gene:
    Search GeneIP for patents involving SPOCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for SPOCK2 (Testican 2/SPOCK2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for SPOCK2 (Testican 2/SPOCK2)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SPOCK2  
     OriGene qPCR primer pairs and template standards for SPOCK2   OriGene Protein Over-expression Lysate for SPOCK2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SPOCK2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPOCK2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SPOCK2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPOCK2   OriGene Custom Protein Services for SPOCK2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPOCK2
     QIAGEN SeqTarget long-range PCR primers for resequencing SPOCK2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOCK2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCK2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOCK2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOCK2
     GenScript Custom Purified and Recombinant Proteins Services for SPOCK2 GenScript cDNA clones with any tag delivered in your preferred vector for SPOCK2
     GenScript Custom Assay Services for SPOCK2 GenScript Custom Superior Antibodies Services for SPOCK2
     GenScript Custom overexpressing Cell Line Services for SPOCK2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SPOCK2 promoter
     Search Chromatin IP Primers for SPOCK2
     RT2 qPCR Primer Assay in human, mouse, rat SPOCK2
     GNC Network for SPOCK2
     SABiosciences PCR Arrays including human, mouse, rat SPOCK2
     Search Tocris compounds for SPOCK2 (TICN2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SPOCK2 antibodies
     SPOCK2 proteins
     SPOCK2 lysates
     Antibodies for SPOCK2
     See all of Abcam's Antibodies, Kits and Proteins for SPOCK2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for SPOCK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK2
     SwitchGear 3'UTR luciferase reporter plasmids for SPOCK2
     SwitchGear Promoter luciferase reporter plasmids for SPOCK2
     Search ThermoFisher Antibodies for SPOCK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SPOCK2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPOCK2
    Customized:
     lentivirus for stable overexpression of SPOCK2
     lentivirus expression plasmids for stable overexpression of SPOCK2
     adenovirus for overexpression of SPOCK2
     LSBio Antibodies in human, mouse, rat for SPOCK2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPOCK2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4