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Aliases for SPOCK2 Gene

Aliases for SPOCK2 Gene

  • SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2 2 3 5
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2 2 3
  • SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 2 3 4
  • Testican-2 3
  • KIAA0275 4
  • TICN2 4

External Ids for SPOCK2 Gene

Previous GeneCards Identifiers for SPOCK2 Gene

  • GC10M072922
  • GC10M073711
  • GC10M073163
  • GC10M073488
  • GC10M073818
  • GC10M067813

Summaries for SPOCK2 Gene

Entrez Gene Summary for SPOCK2 Gene

  • This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for SPOCK2 Gene

SPOCK2 (SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 2) is a Protein Coding gene. Diseases associated with SPOCK2 include Endometriosis Of Ovary. Among its related pathways are Phospholipase-C Pathway and ERK Signaling. GO annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is SPOCK1.

UniProtKB/Swiss-Prot for SPOCK2 Gene

  • May participate in diverse steps of neurogenesis. Binds calcium.

Gene Wiki entry for SPOCK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK2 Gene

Genomics for SPOCK2 Gene

Regulatory Elements for SPOCK2 Gene

Enhancers for SPOCK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G072083 1.6 FANTOM5 ENCODE dbSUPER 23.5 +2.1 2062 7.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF143 ZNF207 SPOCK2 CHST3 ANAPC16 GC10P072062
GH10G072078 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +9.1 9140 2.6 HDGF FOXA2 MLX ARID4B DMAP1 YY1 NFYC MXD4 MIER2 PPARG SPOCK2 CDH23 ASCC1 GC10P072062
GH10G072068 1 dbSUPER 24.7 +19.4 19434 3.2 PKNOX1 MLX ZNF493 ZFP64 ARID4B DMAP1 ZNF48 ZNF121 ZNF202 SP5 SPOCK2 RPL17P50 GC10P072062
GH10G072056 1.2 ENCODE dbSUPER 19.9 +32.1 32058 1.4 HDGF FOXA2 PKNOX1 MLX ARID4B ZNF48 TCF12 SLC30A9 ZNF121 GATA2 SPOCK2 ENSG00000272988 GC10P072062
GH10G072044 1.4 Ensembl ENCODE dbSUPER 16.6 +44.2 44150 1.1 FOXA2 ARID4B ZNF48 RAD21 ZNF366 PCBP1 RELB IKZF2 GATAD2B TBX21 SPOCK2 CDH23 ENSG00000272988 CHST3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPOCK2 on UCSC Golden Path with GeneCards custom track

Promoters for SPOCK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029675 1032 401 SUZ12 RBFOX2 EZH2
ENSR00000260164 1732 201 SUZ12 RBBP5 RBFOX2 EZH2

Genomic Location for SPOCK2 Gene

Chromosome:
10
Start:
72,059,034 bp from pter
End:
72,089,032 bp from pter
Size:
29,999 bases
Orientation:
Minus strand

Genomic View for SPOCK2 Gene

Genes around SPOCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK2 Gene

Proteins for SPOCK2 Gene

  • Protein details for SPOCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92563-TICN2_HUMAN
    Recommended name:
    Testican-2
    Protein Accession:
    Q92563
    Secondary Accessions:
    • C9J767
    • Q6UW87

    Protein attributes for SPOCK2 Gene

    Size:
    424 amino acids
    Molecular mass:
    46779 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA13404.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPOCK2 Gene

Post-translational modifications for SPOCK2 Gene

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides.
  • Glycosylation at posLast=225225, posLast=383383, and posLast=388388
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK2 Gene

Antibody Products

  • R&D Systems Antibodies for SPOCK2 (Testican 2/SPOCK2)
  • Abcam antibodies for SPOCK2

No data available for DME Specific Peptides for SPOCK2 Gene

Domains & Families for SPOCK2 Gene

Gene Families for SPOCK2 Gene

Suggested Antigen Peptide Sequences for SPOCK2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPOCK2: view

No data available for UniProtKB/Swiss-Prot for SPOCK2 Gene

Function for SPOCK2 Gene

Molecular function for SPOCK2 Gene

UniProtKB/Swiss-Prot Function:
May participate in diverse steps of neurogenesis. Binds calcium.

Gene Ontology (GO) - Molecular Function for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 10386950
GO:0005539 glycosaminoglycan binding IEA --
GO:0008191 metalloendopeptidase inhibitor activity TAS 12810672
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with SPOCK2: view
genes like me logo Genes that share phenotypes with SPOCK2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPOCK2 Gene

Localization for SPOCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK2 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOCK2 gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA,NAS 10386950
genes like me logo Genes that share ontologies with SPOCK2: view

Pathways & Interactions for SPOCK2 Gene

genes like me logo Genes that share pathways with SPOCK2: view

Pathways by source for SPOCK2 Gene

Interacting Proteins for SPOCK2 Gene

Gene Ontology (GO) - Biological Process for SPOCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007416 synapse assembly NAS 10386950
GO:0010811 positive regulation of cell-substrate adhesion IEA --
GO:0010951 negative regulation of endopeptidase activity TAS 12810672
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
genes like me logo Genes that share ontologies with SPOCK2: view

No data available for SIGNOR curated interactions for SPOCK2 Gene

Drugs & Compounds for SPOCK2 Gene

(1) Drugs for SPOCK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with SPOCK2: view

Transcripts for SPOCK2 Gene

Unigene Clusters for SPOCK2 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: - - - - - -
SP6:
SP7: - - - - - - - - - - - - - - - - - - -
SP8:
SP9: -

Relevant External Links for SPOCK2 Gene

GeneLoc Exon Structure for
SPOCK2
ECgene alternative splicing isoforms for
SPOCK2

Expression for SPOCK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPOCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK2 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2) and Brain - Cerebellar Hemisphere (x4.8).

Protein differential expression in normal tissues from HIPED for SPOCK2 Gene

This gene is overexpressed in Testis (39.4) and Amniocyte (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPOCK2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SPOCK2 Gene:

SPOCK2

SOURCE GeneReport for Unigene cluster for SPOCK2 Gene:

Hs.523009

mRNA Expression by UniProt/SwissProt for SPOCK2 Gene:

Q92563-TICN2_HUMAN
Tissue specificity: Highly expressed in brain. Also found in lung and testis.

Evidence on tissue expression from TISSUES for SPOCK2 Gene

  • Nervous system(4.9)
  • Muscle(4.1)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with SPOCK2: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOCK2 Gene

Orthologs for SPOCK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPOCK2 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia SPOCK2 34 35
  • 93.45 (n)
dog
(Canis familiaris)
Mammalia SPOCK2 34 35
  • 92.53 (n)
mouse
(Mus musculus)
Mammalia Spock2 34 16 35
  • 90.03 (n)
oppossum
(Monodelphis domestica)
Mammalia SPOCK2 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPOCK2 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spock2 34
  • 88.83 (n)
chicken
(Gallus gallus)
Aves SPOCK2 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPOCK2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spock2 34
  • 77.69 (n)
zebrafish
(Danio rerio)
Actinopterygii spock2 34 35
  • 70.54 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13830 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C54E4.2 35
  • 28 (a)
OneToMany
Species where no ortholog for SPOCK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPOCK2 Gene

ENSEMBL:
Gene Tree for SPOCK2 (if available)
TreeFam:
Gene Tree for SPOCK2 (if available)

Paralogs for SPOCK2 Gene

Paralogs for SPOCK2 Gene

(5) SIMAP similar genes for SPOCK2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPOCK2: view

Variants for SPOCK2 Gene

Sequence variations from dbSNP and Humsavar for SPOCK2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000111162 -- 72,082,172(+) GCCAA(C/T)AAATG intron-variant
rs1000159281 -- 72,086,594(+) AGGAG(A/G)CTGCG intron-variant, utr-variant-3-prime
rs1000199926 -- 72,085,320(+) CACCC(A/G)GCATT intron-variant
rs1000274800 -- 72,085,630(+) CGTCC(G/T)GCTTG intron-variant
rs1000533952 -- 72,087,083(+) CCGGC(A/G)TCGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK2 Gene

Variant ID Type Subtype PubMed ID
esv1328020 CNV deletion 17803354
esv2667322 CNV deletion 23128226
esv2738374 CNV deletion 23290073
esv3546492 CNV deletion 23714750
esv3623790 CNV loss 21293372
esv3891857 CNV loss 25118596
nsv1144500 CNV deletion 24896259
nsv515889 CNV loss 19592680
nsv522541 CNV loss 19592680
nsv7204 OTHER inversion 18451855

Variation tolerance for SPOCK2 Gene

Residual Variation Intolerance Score: 69.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.51; 43.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPOCK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPOCK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK2 Gene

Disorders for SPOCK2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SPOCK2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endometriosis of ovary
  • ovarian endometriosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPOCK2

Genetic Association Database (GAD)
SPOCK2
Human Genome Epidemiology (HuGE) Navigator
SPOCK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPOCK2
genes like me logo Genes that share disorders with SPOCK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPOCK2 Gene

Publications for SPOCK2 Gene

  1. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. (PMID: 10386950) Vannahme C. … Maurer P. (J. Neurochem. 1999) 2 3 4 64
  2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan R.C. … Wallaschofski H. (Hum. Mol. Genet. 2011) 3 46 64
  3. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PMID: 18398821) Nordgard S.H. … Kristensen V.N. (Genes Chromosomes Cancer 2008) 3 46 64
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4 64

Products for SPOCK2 Gene

Sources for SPOCK2 Gene

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