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SPOCK2 Gene

protein-coding   GIFtS: 55
GCID: GC10M073818

Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan...

  Search for SPOCK2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican)
21 2
SPARC/Osteonectin, CWCV, And Kazal-Like Domains Proteoglycan 22 3
KIAA02753 5
testican-22
TICN23

External Ids:    HGNC: 135641   Entrez Gene: 98062   Ensembl: ENSG000001077427   OMIM: 6079885   UniProtKB: Q925633   

Export aliases for SPOCK2 gene to outside databases

Previous GC identifers: GC10M072922 GC10M073711 GC10M073163 GC10M073488 GC10M067813


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SPOCK2 Gene:
This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The
protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan
attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode
different protein isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for SPOCK2 Gene:
SPOCK2 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2) is a protein-coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is SPOCK1.

UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563
Function: May participate in diverse steps of neurogenesis. Binds calcium

Gene Wiki entry for SPOCK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPOCK2 gene promoter:
         MyoD   RelA   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   SRY   FOXO1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPOCK2 promoter sequence
   Search Chromatin IP Primers for SPOCK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPOCK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10pter-q25.3   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

SPOCK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOCK2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M073818:  view genomic region     (about GC identifiers)

Start:
73,818,792 bp from pter      End:
73,848,790 bp from pter
Size:
29,999 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563 (See protein sequence)
Recommended Name: Testican-2 precursor  
Size: 424 amino acids; 46779 Da
Sequence caution: Sequence=BAA13404.2; Type=Erroneous initiation;
Secondary accessions: C9J767 Q6UW87
Alternative splicing: 2 isoforms:  Q92563-1   Q92563-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPOCK2: NX_Q92563

Explore proteomics data for SPOCK2 at MOPED

Post-translational modifications: 

  • Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides (By similarity)1
  • Glycosylation2 at Asn225, Ser383, Ser388

  • See SPOCK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001127906.1  NP_001231879.1  NP_055582.1  

    ENSEMBL proteins: 
     ENSP00000362201   ENSP00000321108   ENSP00000439445   ENSP00000397715  

    SPOCK2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for SPOCK2
    OriGene Custom MassSpec
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    Novus Biologicals SPOCK2 Protein
    Novus Biologicals SPOCK2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SPOCK2 

    SPOCK2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SPOCK2 (Testican 2/SPOCK2)
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    Novus Biologicals SPOCK2 Antibodies
    Abcam antibodies for SPOCK2
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    LSBio Antibodies in human, mouse, rat for SPOCK2

    SPOCK2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SPOCK2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR011992 EF-hand-dom_pair
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR000716 Thyroglobulin_1

    Graphical View of Domain Structure for InterPro Entry Q92563

    ProtoNet protein and cluster: Q92563

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Find genes that share domains with SPOCK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TICN2_HUMAN, Q92563
    Function: May participate in diverse steps of neurogenesis. Binds calcium

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA10386950
    GO:0005515protein binding ----
    GO:0005539glycosaminoglycan binding IEA--
    GO:0050840extracellular matrix binding IEA--
         
    Find genes that share ontologies with SPOCK2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Spock2 (no phenotypes)

    Find genes that share phenotypes with SPOCK2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPOCK2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPOCK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPOCK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPOCK2

    miRNA
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    Block miRNA regulation of human, mouse, rat SPOCK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPOCK2 (see all 65):
    hsa-miR-1321 hsa-miR-200a hsa-miR-342-3p hsa-miR-642b hsa-miR-92b hsa-miR-490-5p hsa-miR-491-3p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPOCK2

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    GenScript: all cDNA clones in your preferred vector (see all 2): SPOCK2 (NM_014767)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TICN2_HUMAN, Q92563: Secreted, extracellular space, extracellular matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS10386950

    Find genes that share ontologies with SPOCK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPOCK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrin Pathway
    FAK1 Signaling0.67
    UPA-UPAR Pathway0.56
    Integrin Pathway0.67
    Inhibition of Angiogenesis by TSP10.50
    GnRH Signaling0.56
    Transendothelial Migration of Leukocytes0.38
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    3Phospholipase-C Pathway
    Phospholipase-C Pathway0.56
    PTEN Pathway0.56

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SPOCK2 (see all 13)
        MAPK Signaling
    Molecular Mechanisms of Cancer
    PTEN Pathway
    Transendothelial Migration of Leukocytes
    UPA-UPAR Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPOCK2
    Interactions:

        GeneGlobe Interaction Network for SPOCK2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SPOCK2 (Q925633 ENSP000003211084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLXNB3Q9ULL43, ENSP000003553784I2D: score=2 STRING: ENSP00000355378
    SPOCK3Q9BQ163, ENSP000003501534I2D: score=2 STRING: ENSP00000350153
    TESQ9UGI83, ENSP000003509374I2D: score=2 STRING: ENSP00000350937
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction IEA--
    GO:0007416synapse assembly NAS10386950
    GO:0010811positive regulation of cell-substrate adhesion IEA--
    GO:0019800peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA--
    GO:0030198extracellular matrix organization NAS10386950

    Find genes that share ontologies with SPOCK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPOCK2 (TICN2)

    1 HMDB Compound for SPOCK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPOCK2 gene (3 alternative transcripts): 
    NM_001134434.1  NM_001244950.1  NM_014767.2  

    Unigene Cluster for SPOCK2:

    Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
    Hs.523009  [show with all ESTs]
    Unigene Representative Sequence: NM_001244950
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373109(uc001jso.2) ENST00000463279 ENST00000469121 ENST00000460053
    ENST00000495888 ENST00000483699 ENST00000317376(uc001jsp.3 uc010qjs.2)
    ENST00000536168 ENST00000412663(uc010qjt.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPOCK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPOCK2 (see all 65):
    hsa-miR-1321 hsa-miR-200a hsa-miR-342-3p hsa-miR-642b hsa-miR-92b hsa-miR-490-5p hsa-miR-491-3p hsa-miR-32
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SPOCK2
    Clone
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    OriGene clones in human, mouse for SPOCK2 (see all 11)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SPOCK2 (NM_014767)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK2
    Primer
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    OriGene qPCR primer pairs and template standards for SPOCK2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPOCK2
      QuantiTect SYBR Green Assays in human, mouse, rat SPOCK2
      QuantiFast Probe-based Assays in human, mouse, rat SPOCK2

    Additional mRNA sequence: 

    AJ001453.1 AK294008.1 AK307091.1 AY358921.1 BC023558.2 BC127951.1 BC127952.1 D87465.1 

    9 DOTS entries:

    DT.454958  DT.100812935  DT.40280876  DT.75140939  DT.100044569  DT.86854644  DT.95212809  DT.91759985 
    DT.95301941 

    Selected AceView cDNA sequences (see all 300):

    BQ002304 BQ129334 BM805735 BE394456 AA910596 BE379134 BX281500 Z38828 
    AI356753 BM903809 BQ631856 AI553739 AA323721 T33680 CA439702 CR611409 
    AI470995 BQ029472 BQ017372 BE378832 AA349626 T33218 AA815454 CK823574 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK2 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                                                -     -     -                                                         
    SP2:                                                                                      -     -                                                         
    SP3:                                                                                                                                                      
    SP4:                                                                                            -                                                         
    SP5:                                            -     -     -                       -     -     -                                                         


    ECgene alternative splicing isoforms for SPOCK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPOCK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAAAGGAA
    SPOCK2 Expression
    About this image


    SPOCK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Ventral/hypothalamic-like neurons
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+BMP4-induced E15 cells
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
    SPOCK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPOCK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523009

    UniProtKB/Swiss-Prot: TICN2_HUMAN, Q92563
    Tissue specificity: Highly expressed in brain. Also found in lung and testis

        Custom PCR Arrays for SPOCK2
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat SPOCK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPOCK2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spock21 , 5 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more1, 5 90.03(n)1
    93.35(a)1
      10 (29.69 cM)5
    942141  NM_052994.21  NP_443720.11 
     601062195 
    chicken
    (Gallus gallus)
    Aves SPOCK26
    sparc/osteonectin, cwcv and kazal-like domains pro...
    67(a)
    1 ↔ 1
    6(11067606-11069056)
    lizard
    (Anolis carolinensis)
    Reptilia SPOCK26
    sparc/osteonectin, cwcv and kazal-like domains pro...
    84(a)
    1 ↔ 1
    3(51363684-51493625)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia spock21 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 77.69(n)
    83.33(a)
      100144943  NM_001126515.1  NP_001119987.1 
    zebrafish
    (Danio rerio)
    Actinopterygii spock21 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 70.54(n)
    69.77(a)
      100320541  XM_002664184.3  XP_002664230.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138306
    --
    19(a)
    1 → many
    3R(18896371-18938437)
    worm
    (Caenorhabditis elegans)
    Secernentea C54E4.26
    Protein C54E4.2, isoform a (C54E4.2) mRNA, complet...
    28(a)
    1 → many
    IV(2136895-2146461) WBGene00016918


    ENSEMBL Gene Tree for SPOCK2 (if available)
    TreeFam Gene Tree for SPOCK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPOCK2 gene
    SPOCK12  SPOCK32  
    5 SIMAP similar genes for SPOCK2 using alignment to 3 protein entries:     TICN2_HUMAN (see all proteins):
    tmp_locus_3    SPOCK3    AGRN    SPOCK1    WUGSC

    Find genes that share paralogs with SPOCK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPOCK2 (see all 757)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1446636561,2
    --73818293(+) CTAGCC/GGCGCT 2 -- int10--------
    rs1894889531,2
    --73818312(+) TGGTTC/TTACCT 2 -- int10--------
    rs1810398661,2
    --73818343(+) AGAGGC/TGGTTG 2 -- int10--------
    rs79075761,2
    C,F,H--73818346(+) GGTGGT/CTGAAG 2 -- int14Minor allele frequency- C:0.00NS EA 408
    rs1865407651,2
    --73818406(+) GGTGAC/TGGCTG 2 -- int10--------
    rs1897060041,2
    --73818548(+) TCCTAA/GGCTCA 2 -- int10--------
    rs1814863061,2
    C--73818630(+) CACTAC/TGTTGC 2 -- int10--------
    rs1395210591,2
    C--73818641(+) CTAGG-/CCAGTC 2 -- int10--------
    rs1137438171,2
    C,F--73818721(+) ACCACG/ACTCAG 2 -- int12Minor allele frequency- A:0.07CSA WA 120
    rs1859378371,2
    --73818728(+) TCAGCA/CATAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for SPOCK2 (73818792 - 73848790 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SPOCK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2667322CNV Deletion23128226
    esv1328020CNV Deletion17803354
    esv2738374CNV Deletion23290073
    nsv522541CNV Loss19592680
    nsv515889CNV Loss19592680
    nsv895718CNV Loss21882294
    nsv895720CNV Loss21882294
    nsv7204OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607988    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for SPOCK2:
    Endometrioid ovary carcinoma

    Find genes that share disorders with SPOCK2           About GenesLikeMe

    Genetic Association Database (GAD): SPOCK2
    Human Genome Epidemiology (HuGE) Navigator: SPOCK2 (2 documents)

    Export disorders for SPOCK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPOCK2 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with SPOCK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain. (PubMed id 10386950)1, 2, 3 Vannahme C.... Maurer P. (J. Neurochem. 1999)
    2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PubMed id 21216879)1, 4 Kaplan R.C....Wallaschofski H. (Hum. Mol. Genet. 2011)
    3. Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. (PubMed id 18398821)1, 4 Nordgard S.H....Kristensen V.N. (amp 2008)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PubMed id 9039502)1, 2 Nagase T.... Nomura N. (DNA Res. 1996)
    9. Genome-wide meta-analyses of smoking behaviors in African Americans. (PubMed id 22832964)1 David S.P....Furberg H. (Transl Psychiatry 2012)
    10. Identification of SPOCK2 as a susceptibility gene for bronchopulmonary dysplasia. (PubMed id 21836138)1 Hadchouel A....Delacourt C. (Am. J. Respir. Crit. Care Med. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9806 HGNC: 13564 AceView: SPOCK2 Ensembl:ENSG00000107742 euGenes: HUgn9806
    ECgene: SPOCK2 H-InvDB: SPOCK2

    (According to HUGE)
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    HUGE: KIAA0275

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPOCK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPOCK2 gene:
    Search GeneIP for patents involving SPOCK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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