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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPOCK1 Gene

protein-coding   GIFtS: 54
GCID: GC05M136339

sparc/osteonectin, cwcv and kazal-like domains proteoglycan...

(Previous names: sparc/osteonectin, cwcv and kazal-like domains proteoglycan...)
(Previous symbols: TIC1, SPOCK)
 Explore 5 diseases affiliated with
SPOCK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPOCK1    

Aliases
for SPOCK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 11 2     Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican)1
SPOCK1 2 3 5     TESTICAN2
TIC11 2 3     TICN13
Testican-11     Protein SPOCK3

External Ids:    HGNC: 112511   Entrez Gene: 66952   Ensembl: ENSG000001523777   OMIM: 6022645   UniProtKB: Q086293   

Export aliases for SPOCK1 gene to outside databases

Previous GC identifer: GC05M131500


Summaries
for SPOCK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPOCK1:
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains.
The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its
function may be related to protease inhibition. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629
Function: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in
the central nervous system

Gene Wiki entry for SPOCK1


Genomic Views
for SPOCK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPOCK1 gene promoter:
         ISGF-3   Tal-1beta   Nkx6-1   POU2F1   FOXJ2 (long isoform)   FOXJ2   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPOCK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPOCK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOCK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

SPOCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOCK1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M136339:  view genomic region     (about GC identifiers)

Start:
 136,310,987 bp from pter      End:
 136,934,068 bp from pter
Size:
 623,082 bases      Orientation:
 minus strand

Proteins
for SPOCK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629 (See protein sequence)
Recommended Name: Testican-1 precursor  
Size: 439 amino acids; 49124 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence caution: Sequence=BAD92938.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KSW3 Q59EW0 Q8N630 Q9UCL8

Explore the universe of human proteins at neXtProt for SPOCK1: NX_Q08629

Post-translational modifications:

  • O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08629

    • SPOCK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004589.1  
    ENSEMBL proteins: 
     ENSP00000378401   ENSP00000421677   ENSP00000421418   ENSP00000424517   ENSP00000282223  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for SPOCK1 (Testican 1/SPOCK1)
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    Novus Biologicals SPOCK1 Protein
    Novus Biologicals SPOCK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPOCK1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA14511383
    GO:0005737cytoplasm ISS--
    GO:0014069postsynaptic density NAS9181134
    GO:0016528sarcoplasm ISS--


    SPOCK1 for ontologies           About GeneDecksing



    SPOCK1 Antibody Products: 
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    Uscn ELISAs and CLIAs for SPOCK1

    Protein Domains /
    Families
    for SPOCK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPOCK1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR002350 Prot_inh_Kazal
     IPR011992 EF-hand-like_dom
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR000716 Thyroglobulin_1
     IPR011497 Kazal-type_dom

    Graphical View of Domain Structure for InterPro Entry Q08629

    ProtoNet protein and cluster: Q08629

    2 Blocks protein families:
    IPB000716 Thyroglobulin type-1
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    Function
    for SPOCK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629
    Function: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in
    the central nervous system

    miRNA
    Products:            		 OriGene 3'-UTR Clone: SPOCK1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK1 (see all 79):
    hsa-miR-631 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-3148 hsa-miR-510 hsa-miR-3909 hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: SPOCK1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPOCK1 (see all 4)
    OriGene shRNA RFP: SPOCK1
    OriGene siRNA: SPOCK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCK1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPOCK1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPOCK1 (see all 6)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPOCK1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPOCK1 (NM_004598)
    Sino Biological Human cDNA Clone for SPOCK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK1 

    Cell Line
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    Search LifeMap BioReagents cell lines for SPOCK1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK1

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS14511383
    GO:0004869cysteine-type endopeptidase inhibitor activity IDA14511383
    GO:0005509calcium ion binding IDA9323035
    GO:0008191metalloendopeptidase inhibitor activity IDA11751414


    SPOCK1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Spock1tm1Htmn for SPOCK1
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Spock1):
     normal 

    SPOCK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SPOCK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Adipogenesis
    		Adipogenesis1.00


    1 BioSystems Pathway for SPOCK1 
        Adipogenesis


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPOCK1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for SPOCK1 (Q086293 ENSP000002822234) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP14P502813, ENSP000003082084I2D: score=1 STRING: ENSP00000308208
    MMP2P082533, ENSP000002190704I2D: score=1 STRING: ENSP00000219070
    MMP3P082543, ENSP000002998554I2D: score=1 STRING: ENSP00000299855
    SHC1P293533I2D: score=2 
    TNFP013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS8389704
    GO:0001764neuron migration ISS--
    GO:0007155cell adhesion NAS8389704
    GO:0007165signal transduction IEA--
    GO:0007399nervous system development NAS9181134


    SPOCK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPOCK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPOCK1
    Search CenterWatch for drugs/clinical trials and news about SPOCK1 / TICN1 

    Transcripts
    for SPOCK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPOCK1 gene: 
    NM_004598.3  

    Unigene Cluster for SPOCK1:

    Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
    Hs.596136  [show with all ESTs]
    Unigene Representative Sequence: NM_004598
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394945(uc003lbo.3 uc003lbp.3) ENST00000515091 ENST00000509978
    ENST00000508642 ENST00000510689 ENST00000510405 ENST00000505690 ENST00000503916
    ENST00000509293 ENST00000282223

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SPOCK1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK1 (see all 79):
    hsa-miR-631 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-3148 hsa-miR-510 hsa-miR-3909 hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: SPOCK1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPOCK1 (see all 4)
    OriGene shRNA RFP: SPOCK1
    OriGene siRNA: SPOCK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCK1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPOCK1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPOCK1 (NM_004598)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPOCK1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPOCK1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOCK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOCK1

    Additional cDNA sequence: 

    AB209701.1 AF231124.1 AK094489.1 BC030691.2 

    13 DOTS entries:

    DT.97857476  DT.95124677  DT.101967721  DT.95331642  DT.120815763  DT.100037804  DT.120815755  DT.100711206 
    DT.120815632  DT.91750267  DT.100727843  DT.120815883  DT.91760126 

    1 AceView cDNA sequence:

    BI550122 

    GeneLoc Exon Structure


    Expression
    for SPOCK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPOCK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAATACCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPOCK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    BrainCerebral CortexBrain
    EyeRetinaEye
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11) 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (Generation of mesend...)

    See SPOCK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPOCK1

    SOURCE GeneReport for Unigene cluster: Hs.596136
        SABiosciences Custom PCR Arrays for SPOCK1
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK1

    Orthologs
    for SPOCK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SPOCK1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Spock11 , 5 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more1, 5 89.75(n)1
    95.22(a)1    		   13 (30.50 cM)5
    207451  NM_009262.31  NP_033288.21 
     574292955 
    chicken
    (Gallus gallus)    		 Aves SPOCK11 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 78.72(n)
    85.45(a)    		   416304  XM_414622.3  XP_414622.3 
    lizard
    (Anolis carolinensis)    		 Reptilia SPOCK16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343448.1(330051-674348)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003315401 testican-1-like 66.48(n)
    69.27(a)    		   100331540  XM_002664265.2  XP_002664311.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG138306
    		 --
    		 18(a)
    		 1 → many
    		 3R(18896371-18938437)
    worm
    (Caenorhabditis elegans)    		 Secernentea C54E4.26
    		 Protein C54E4.2, isoform a
    		 29(a)
    		 1 → many
    		 IV(2136895-2146461)


    ENSEMBL Gene Tree for SPOCK1 (if available)
    TreeFam Gene Tree for SPOCK1 (if available) 

    Paralogs
    for SPOCK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPOCK1 gene
    SPOCK32  SPOCK22  
    4 SIMAP similar genes for SPOCK1 using alignment to 6 protein entries:     TICN1_HUMAN (see all proteins):
    tmp_locus_3    SPOCK3    SPOCK2    WUGSC

    SPOCK1 for paralogs           About GeneDecksing



    Genomic Variants
    for SPOCK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8599 NCBI SNPs in SPOCK1 are shown (see all 8599)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1494155181,2
    		C,Fother136324296(+) CCAGGG/AAGTCC 2 /S /F mis11Minor allele frequency- A:0.00NA 4550
    rs113059821,2
    		C,--131529563(+) TTTTG-/AAAAAA 1 -- int1 trp31Minor allele frequency- A:0.00NA 2
    rs1408269951,2
    		--136310500(+) GACACA/GTCATC 1 -- ds50010--------
    rs1166020101,2
    		F,--136310520(+) ATTCTC/TATAAG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1835448401,2
    		--136310676(+) CTTCAC/TTCACT 1 -- ds50010--------
    rs610951191,2
    		C,--136310724(+) TAAGAG/AGCCAC 1 -- ds50012Minor allele frequency- A:0.02WA 120
    rs1868134891,2
    		--136310962(+) TCCACA/CCAATG 1 -- ds50010--------
    rs1502290771,2
    		--136310979(+) AAACAC/TTCAGA 1 -- ds50010--------
    rs1468108371,2
    		--136311098(+) TCTACA/GTGGAA 1 -- ut310--------
    rs562623241,2
    		C,F,--136311100(+) TACGTG/AGAAAA 1 -- ut314Minor allele frequency- A:0.08WA CSA 124

    HapMap Linkage Disequilibrium report for SPOCK1 (136310987 - 136560987 bp, first 250kb of SPOCK1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SPOCK1
         3 CNVs: 93249 36347 81051

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPOCK1
    DNA2.0 Custom Variant and Variant Library Synthesis for SPOCK1

    Disorders / Diseases
    for SPOCK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPOCK1 for disorders           About GeneDecksing

    OMIM gene information: 602264    OMIM disorders: --

    5 diseases for SPOCK1:    About MalaCards
    pancreatic cancer    prostate cancer    pancreatitis    prostatitis
    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: SPOCK1 (2 documents)

    Export disorders for SPOCK1 gene to outside databases

    Publications
    for SPOCK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPOCK1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with SPOCK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. (PubMed id 9545645)1, 3, 9 Charbonnier F....Alliel P.M. (1998)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    4. Endothelial cell expression of testican mRNA. (PubMed id 9272383)1, 2 Marr H.S.... Edgell C.J. (1997)
    5. Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. (PubMed id 8389704)1, 2 Alliel P.M.... Bonnet F.J. (1993)
    6. Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (PubMed id 19282985)1, 9 Liu Y.Z....Deng H.W. (2009)
    7. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (2013)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    10. Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater. (PubMed id 16596217)1 Prenzel K.L....Schneider P.M. (2006)

    External Searches for SPOCK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing SPOCK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6695 HGNC: 11251 AceView: SPOCK.2 Ensembl:ENSG00000152377 euGenes: HUgn6695
    ECgene: SPOCK1 H-InvDB: SPOCK1

    Other Databases showing SPOCK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPOCK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPOCK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPOCK1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SPOCK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPOCK1 gene:
    Search GeneIP for patents involving SPOCK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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