Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPOCK1 Gene

Aliases for SPOCK1 Gene

  • SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 1 2 3 5
  • SPOCK 3 4
  • TIC1 3 4
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 1 3
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2
  • Protein SPOCK 4
  • Testican-1 3
  • TESTICAN 3
  • TICN1 4

External Ids for SPOCK1 Gene

Previous HGNC Symbols for SPOCK1 Gene

  • TIC1
  • SPOCK

Previous GeneCards Identifiers for SPOCK1 Gene

  • GC05M136339
  • GC05M131500
  • GC05M136310

Summaries for SPOCK1 Gene

Entrez Gene Summary for SPOCK1 Gene

  • This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPOCK1 Gene

SPOCK1 (SPARC/Osteonectin, Cwcv And Kazal Like Domains Proteoglycan 1) is a Protein Coding gene. Diseases associated with SPOCK1 include Chylothorax, Congenital and Coproporphyria. Among its related pathways are Phospholipase-C Pathway and ERK Signaling. GO annotations related to this gene include calcium ion binding and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SPOCK3.

UniProtKB/Swiss-Prot for SPOCK1 Gene

  • May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

Gene Wiki entry for SPOCK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK1 Gene

Genomics for SPOCK1 Gene

Regulatory Elements for SPOCK1 Gene

Enhancers for SPOCK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G138335 1.4 ENCODE dbSUPER 10.6 -739.2 -739162 5.0 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC HNRNPA0 CDC23 KDM3B RPL7P19 NME5 SPOCK1 LRRTM2 FAM13B REEP2 CDC25C
GH05G137620 1 Ensembl ENCODE 11.6 -23.9 -23852 2.7 GTF2F1 USF1 MAX CEBPG YY1 NFYB FOS TCF7L2 SOX5 BHLHE40 SPOCK1 MIR874 KLHL3 NME5 EGR1 PIR48538 GC05M137622 GC05M137619
GH05G137618 0.9 Ensembl ENCODE 11.6 -20.8 -20814 1.7 GTF2F1 NFIB MNT REST CTBP1 NFIC RAD51 JUND GATA3 CREB1 SPOCK1 KLHL3 REEP2 LOC101928005 GC05M137622 PIR48538 GC05P137610
GH05G137629 0.9 Ensembl ENCODE 11.1 -31.5 -31478 0.3 CTCF ZNF654 PKNOX1 TRIM22 REST ZIC2 ZNF2 RAD21 RFX5 ZNF366 KLHL3 SPOCK1 RNU6-1148P REEP2 GC05M137619 MIR874
GH05G137145 1.7 FANTOM5 Ensembl ENCODE dbSUPER 5.6 +451.6 451557 2.9 FEZF1 BMI1 GATA2 ZNF366 HSF1 ZSCAN5C SCRT2 FOSL2 FOS NFE2L2 SPOCK1 LOC105379192 GC05P137182
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPOCK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPOCK1 Gene

Chromosome:
5
Start:
136,975,298 bp from pter
End:
137,598,379 bp from pter
Size:
623,082 bases
Orientation:
Minus strand

Genomic View for SPOCK1 Gene

Genes around SPOCK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPOCK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPOCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK1 Gene

Proteins for SPOCK1 Gene

  • Protein details for SPOCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08629-TICN1_HUMAN
    Recommended name:
    Testican-1
    Protein Accession:
    Q08629
    Secondary Accessions:
    • B3KSW3
    • Q59EW0
    • Q8N630
    • Q9UCL8

    Protein attributes for SPOCK1 Gene

    Size:
    439 amino acids
    Molecular mass:
    49124 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92938.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SPOCK1 Gene

Post-translational modifications for SPOCK1 Gene

  • O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate.
  • Glycosylation at Ser131, Thr228, isoforms=383, and posLast=388388
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK1 Gene

Antibody Products

  • R&D Systems Antibodies for SPOCK1 (Testican 1/SPOCK1)
  • Abcam antibodies for SPOCK1

No data available for DME Specific Peptides for SPOCK1 Gene

Domains & Families for SPOCK1 Gene

Gene Families for SPOCK1 Gene

Suggested Antigen Peptide Sequences for SPOCK1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPOCK1: view

No data available for UniProtKB/Swiss-Prot for SPOCK1 Gene

Function for SPOCK1 Gene

Molecular function for SPOCK1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

Gene Ontology (GO) - Molecular Function for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity NAS 14511383
GO:0004869 cysteine-type endopeptidase inhibitor activity IDA 14511383
GO:0005509 calcium ion binding IEA,IDA 9323035
GO:0008191 metalloendopeptidase inhibitor activity IDA 11751414
genes like me logo Genes that share ontologies with SPOCK1: view
genes like me logo Genes that share phenotypes with SPOCK1: view

Animal Models for SPOCK1 Gene

MGI Knock Outs for SPOCK1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPOCK1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SPOCK1 Gene

Localization for SPOCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPOCK1 gene
Compartment Confidence
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 14511383
GO:0005737 cytoplasm ISS --
GO:0014069 postsynaptic density NAS 9181134
genes like me logo Genes that share ontologies with SPOCK1: view

Pathways & Interactions for SPOCK1 Gene

genes like me logo Genes that share pathways with SPOCK1: view

Pathways by source for SPOCK1 Gene

1 BioSystems pathway for SPOCK1 Gene

Gene Ontology (GO) - Biological Process for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 8389704
GO:0001764 neuron migration ISS --
GO:0007155 cell adhesion NAS 8389704
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development NAS 9181134
genes like me logo Genes that share ontologies with SPOCK1: view

No data available for SIGNOR curated interactions for SPOCK1 Gene

Drugs & Compounds for SPOCK1 Gene

No Compound Related Data Available

Transcripts for SPOCK1 Gene

mRNA/cDNA for SPOCK1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPOCK1 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK1 Gene

No ASD Table

Relevant External Links for SPOCK1 Gene

GeneLoc Exon Structure for
SPOCK1
ECgene alternative splicing isoforms for
SPOCK1

Expression for SPOCK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPOCK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0).

Protein differential expression in normal tissues from HIPED for SPOCK1 Gene

This gene is overexpressed in Vitreous humor (58.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SPOCK1 Gene



Protein tissue co-expression partners for SPOCK1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPOCK1 Gene:

SPOCK1

SOURCE GeneReport for Unigene cluster for SPOCK1 Gene:

Hs.596136

Evidence on tissue expression from TISSUES for SPOCK1 Gene

  • Nervous system(5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SPOCK1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPOCK1 Gene

Orthologs for SPOCK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPOCK1 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia SPOCK1 34 35
  • 92.06 (n)
cow
(Bos Taurus)
Mammalia SPOCK1 34 35
  • 91.34 (n)
rat
(Rattus norvegicus)
Mammalia Spock1 34
  • 90.13 (n)
mouse
(Mus musculus)
Mammalia Spock1 34 16 35
  • 89.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SPOCK1 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPOCK1 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPOCK1 34 35
  • 78.93 (n)
lizard
(Anolis carolinensis)
Reptilia SPOCK1 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii SPOCK1 35
  • 68 (a)
OneToOne
LOC100331540 34
  • 66.93 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13830 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C54E4.2 35
  • 29 (a)
OneToMany
Species where no ortholog for SPOCK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPOCK1 Gene

ENSEMBL:
Gene Tree for SPOCK1 (if available)
TreeFam:
Gene Tree for SPOCK1 (if available)

Paralogs for SPOCK1 Gene

Paralogs for SPOCK1 Gene

(5) SIMAP similar genes for SPOCK1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SPOCK1: view

Variants for SPOCK1 Gene

Sequence variations from dbSNP and Humsavar for SPOCK1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs587777311 Uncertain significance 137,140,688(+) ATGGG(A/T)CCAGG reference, missense
rs111393448 Benign 137,498,449(+) GGAAA(C/T)TGCCG reference, missense
rs1000000681 -- 137,102,412(+) CTTTG(C/T)AGAAT intron-variant
rs1000001434 -- 137,008,292(+) ATAAT(-/AA)ATACA intron-variant
rs1000007305 -- 137,013,439(+) GAGAG(C/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK1 Gene

Variant ID Type Subtype PubMed ID
dgv1647e212 CNV loss 25503493
esv1973589 CNV deletion 18987734
esv2657276 CNV deletion 23128226
esv2661840 CNV deletion 23128226
esv2677084 CNV deletion 23128226
esv3306429 CNV mobile element insertion 20981092
esv3368747 CNV insertion 20981092
esv3443426 CNV insertion 20981092
esv3445385 CNV duplication 20981092
esv3570425 CNV loss 25503493
esv3606891 CNV loss 21293372
esv3606892 CNV gain 21293372
esv3606893 CNV gain 21293372
esv3606894 CNV gain 21293372
esv3606895 CNV loss 21293372
esv3606896 CNV loss 21293372
esv3606898 CNV loss 21293372
esv3606900 CNV loss 21293372
esv3606901 CNV loss 21293372
nsv1015658 CNV gain 25217958
nsv1029688 CNV loss 25217958
nsv1114732 CNV deletion 24896259
nsv328026 CNV insertion 16902084
nsv462459 CNV loss 19166990
nsv476258 CNV novel sequence insertion 20440878
nsv476867 CNV novel sequence insertion 20440878
nsv5020 CNV deletion 18451855
nsv515019 CNV gain 21397061
nsv599797 CNV loss 21841781
nsv830497 CNV loss 17160897
nsv830498 CNV gain 17160897

Variation tolerance for SPOCK1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPOCK1 Gene

Human Gene Mutation Database (HGMD)
SPOCK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPOCK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK1 Gene

Disorders for SPOCK1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SPOCK1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chylothorax, congenital
  • congenital chylothorax
coproporphyria
  • harderoporphyria
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SPOCK1

Genetic Association Database (GAD)
SPOCK1
Human Genome Epidemiology (HuGE) Navigator
SPOCK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPOCK1
genes like me logo Genes that share disorders with SPOCK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPOCK1 Gene

Publications for SPOCK1 Gene

  1. Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (PMID: 19282985) Liu Y.Z. … Deng H.W. (PLoS Genet. 2009) 3 22 46 64
  2. Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. (PMID: 9545645) Charbonnier F. … Alliel P.M. (Genomics 1998) 2 3 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4 64

Products for SPOCK1 Gene

Sources for SPOCK1 Gene

Content
Loading form....