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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPOCK1 Gene

protein-coding   GIFtS: 53
GCID: GC05M136339

Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan...

(Previous names: sparc/osteonectin, cwcv and kazal-like domains proteoglycan...)
(Previous symbols: TIC1, SPOCK)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican)
11 2
     TESTICAN2
SPOCK1 2 3 5     testican-12
TIC11 2 3     TICN13
Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican)1     Protein SPOCK3

External Ids:    HGNC: 112511   Entrez Gene: 66952   Ensembl: ENSG000001523777   OMIM: 6022645   UniProtKB: Q086293   

Export aliases for SPOCK1 gene to outside databases

Previous GC identifer: GC05M131500


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPOCK1 Gene:
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate
chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors
suggests its function may be related to protease inhibition. (provided by RefSeq, Jul 2008)

GeneCards Summary for SPOCK1 Gene: 
SPOCK1 (sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1) is a protein-coding gene. Diseases associated with SPOCK1 include pancreatic cancer, and pancreatitis. GO annotations related to this gene include cysteine-type endopeptidase inhibitor activity and calcium ion binding. An important paralog of this gene is SPOCK3.

UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629
Function: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms
in the central nervous system

Gene Wiki entry for SPOCK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPOCK1 gene promoter:
         ISGF-3   Tal-1beta   Nkx6-1   POU2F1   FOXJ2 (long isoform)   FOXJ2   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPOCK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPOCK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOCK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

SPOCK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOCK1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M136339:  view genomic region     (about GC identifiers)

Start:
136,310,987 bp from pter      End:
136,934,068 bp from pter
Size:
623,082 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629 (See protein sequence)
Recommended Name: Testican-1 precursor  
Size: 439 amino acids; 49124 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Sequence caution: Sequence=BAD92938.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KSW3 Q59EW0 Q8N630 Q9UCL8

Explore the universe of human proteins at neXtProt for SPOCK1: NX_Q08629

Explore proteomics data for SPOCK1 at MOPED 

Post-translational modifications:

  • UniProtKB: O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08629

  • SPOCK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPOCK1 Protein Expression
    REFSEQ proteins: NP_004589.1  
    ENSEMBL proteins: 
     ENSP00000378401   ENSP00000421677   ENSP00000421418   ENSP00000424517   ENSP00000282223  

    Human Recombinant Protein Products for SPOCK1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals SPOCK1 Protein
    Novus Biologicals SPOCK1 Lysate
    Sino Biological Recombinant Protein for SPOCK1
    Sino Biological Cell Lysate for SPOCK1 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0005615extracellular space IDA14511383
    GO:0005737cytoplasm ISS--
    GO:0014069postsynaptic density NAS9181134
    GO:0016528sarcoplasm ISS--

    SPOCK1 for ontologies           About GeneDecksing



    SPOCK1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR002350 Kazal_dom
     IPR011992 EF-hand-like_dom
     IPR019577 SPARC/Testican_Ca-bd-dom
     IPR000716 Thyroglobulin_1

    Graphical View of Domain Structure for InterPro Entry Q08629

    ProtoNet protein and cluster: Q08629

    2 Blocks protein domains:
    IPB000716 Thyroglobulin type-1
    IPB011497 Protease inhibitor


    UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629
    Similarity: Contains 1 Kazal-like domain
    Similarity: Contains 1 thyroglobulin type-1 domain


    SPOCK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TICN1_HUMAN, Q08629
    Function: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms
    in the central nervous system

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity NAS14511383
    GO:0004869cysteine-type endopeptidase inhibitor activity IDA14511383
    GO:0005509calcium ion binding IDA9323035
    GO:0005515protein binding ----
    GO:0008191metalloendopeptidase inhibitor activity IDA11751414
         
    SPOCK1 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Spock1):
     normal 

    SPOCK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Spock1tm1Htmn for SPOCK1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPOCK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPOCK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPOCK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPOCK1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK1 (see all 79):
    hsa-miR-631 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-3148 hsa-miR-510 hsa-miR-3909 hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SPOCK1 (see all 9)
    OriGene ORF clones in mouse, rat for SPOCK1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPOCK1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Adipogenesis
    Adipogenesis


    1 BioSystems Pathway for SPOCK1
        Adipogenesis



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPOCK1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/12 Interacting proteins for SPOCK1 (Q086293 ENSP000002822234) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000204490P013753I2D: score=1 
    ENSG00000206439P013753I2D: score=1 
    ENSG00000223952P013753I2D: score=1 
    ENSG00000228321P013753I2D: score=1 
    ENSG00000228849P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS8389704
    GO:0001764neuron migration ISS--
    GO:0007155cell adhesion NAS8389704
    GO:0007165signal transduction IEA--
    GO:0007399nervous system development NAS9181134

    SPOCK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPOCK1 (TICN1)

    Search CenterWatch for drugs/clinical trials and news about SPOCK1 / TICN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPOCK1 gene: 
    NM_004598.3  

    Unigene Cluster for SPOCK1:

    Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
    Hs.596136  [show with all ESTs]
    Unigene Representative Sequence: NM_004598
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394945(uc003lbo.3 uc003lbp.3) ENST00000515091 ENST00000509978
    ENST00000508642 ENST00000510689 ENST00000510405 ENST00000505690 ENST00000503916
    ENST00000509293 ENST00000282223
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPOCK1
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate SPOCK1 (see all 79):
    hsa-miR-631 hsa-miR-138-2* hsa-miR-502-3p hsa-miR-3148 hsa-miR-510 hsa-miR-3909 hsa-miR-4273 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidSPOCK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene ORF clones in mouse, rat for SPOCK1
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    GenScript: all cDNA clones in your preferred vector: SPOCK1 (NM_004598)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPOCK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCK1
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                         Customized lentivirus expression plasmids for stable overexpression of SPOCK1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPOCK1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOCK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOCK1

    Additional mRNA sequence: 

    AB209701.1 AF231124.1 AK094489.1 BC030691.2 

    13 DOTS entries:

    DT.97857476  DT.95124677  DT.101967721  DT.95331642  DT.120815763  DT.100037804  DT.120815755  DT.100711206 
    DT.120815632  DT.91750267  DT.100727843  DT.120815883  DT.91760126 

    1 AceView cDNA sequence:

    BI550122 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPOCK1 expression in normal human tissues (normalized intensities)      SPOCK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATACCTT
    SPOCK1 Expression
    About this image


    SPOCK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
             ganglion/cranial/facial VII   
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor E72
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 4 entries
             PureStem SK11, NCr-fac & Meso-prx Progenitor
             sensory organ/nose/vomeronasal organ   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 4 entries
             autonomic/sympathetic/ganglion   
     
     Tooth (Integumentary System)    fully expand to see all 4 entries
             visceral organ/oral region/upper jaw   

    See SPOCK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPOCK1

    SOURCE GeneReport for Unigene cluster: Hs.596136
        SABiosciences Custom PCR Arrays for SPOCK1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPOCK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SPOCK1 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spock11 , 5 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more1, 5 89.75(n)1
    95.22(a)1
      13 (30.50 cM)5
    207451  NM_009262.31  NP_033288.21 
     574292955 
    chicken
    (Gallus gallus)
    Aves SPOCK11 sparc/osteonectin, cwcv and kazal-like domains proteoglycan more 78.72(n)
    85.45(a)
      416304  XM_414622.3  XP_414622.3 
    lizard
    (Anolis carolinensis)
    Reptilia SPOCK16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343448.1(330051-674351)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003315401 testican-1-like 66.48(n)
    69.27(a)
      100331540  XM_002664265.2  XP_002664311.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138306
    --
    18(a)
    1 → many
    3R(18896371-18938437)
    worm
    (Caenorhabditis elegans)
    Secernentea C54E4.26
    Protein C54E4.2, isoform b
    30(a)
    1 → many
    IV(2136895-2146461)


    ENSEMBL Gene Tree for SPOCK1 (if available)
    TreeFam Gene Tree for SPOCK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPOCK1 gene
    SPOCK32  SPOCK22  
    5 SIMAP similar genes for SPOCK1 using alignment to 6 protein entries:     TICN1_HUMAN (see all proteins):
    tmp_locus_3    SPOCK3    AGRN    SPOCK2    WUGSC

    SPOCK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9836 SNPs in SPOCK1 are shown (see all 9836)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494155181,2
    C,Funtested1136324296(+) CCAGGG/AAGTCC 2 /S /F mis11Minor allele frequency- A:0.00NA 4550
    rs1408269951,2
    --136310500(+) GACACA/GTCATC 1 -- ds50010--------
    rs1166020101,2
    F--136310520(+) ATTCTC/TATAAG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1835448401,2
    --136310676(+) CTTCAC/TTCACT 1 -- ds50010--------
    rs610951191,2
    C,F--136310724(+) TAAGAG/AGCCAC 1 -- ds50012Minor allele frequency- A:0.02WA 120
    rs1868134891,2
    --136310962(+) TCCACA/CCAATG 1 -- ds50010--------
    rs1502290771,2
    --136310979(+) AAACAC/TTCAGA 1 -- ds50010--------
    rs1468108371,2
    --136311098(+) TCTACA/GTGGAA 1 -- ut310--------
    rs562623241,2
    C,F--136311100(+) TACGTG/AGAAAA 1 -- ut314Minor allele frequency- A:0.08WA CSA 124
    rs1405388101,2
    --136311117(+) AGAATG/TTACTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SPOCK1 (136310987 - 136560987 bp, first 250kb of SPOCK1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for SPOCK1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2677084CNV Deletion23128226
    esv2661840CNV Deletion23128226
    esv1973589CNV Deletion18987734
    esv2657276CNV Deletion23128226
    esv270705CNV Insertion20981092
    nsv328026CNV Insertion16902084
    nsv5020CNV Loss18451855
    nsv882933CNV Loss21882294
    nsv830497CNV Loss17160897
    nsv462459CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602264    OMIM disorders: --

    6 diseases for SPOCK1:    About MalaCards
    pancreatic cancer    pancreatitis    prostate cancer    prostatitis
    endotheliitis    neuronitis


    SPOCK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPOCK1
    Human Genome Epidemiology (HuGE) Navigator: SPOCK1 (2 documents)

    Export disorders for SPOCK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPOCK1 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with SPOCK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (PubMed id 19282985)1, 4, 9 Liu Y.Z....Deng H.W. (2009)
    2. Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. (PubMed id 9545645)1, 3, 9 Charbonnier F....Alliel P.M. (1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    6. Endothelial cell expression of testican mRNA. (PubMed id 9272383)1, 2 Marr H.S.... Edgell C.J. (1997)
    7. Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. (PubMed id 8389704)1, 2 Alliel P.M.... Bonnet F.J. (1993)
    8. LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. (PubMed id 23234360)2 Halim A.... Nilsson J. (2013)
    9. SPOCK1 is regulated by CHD1L and blocks apoptosis and promotes HCC cell invasiveness and metastasis in mice. (PubMed id 23022495)1 Li Y....Guan X.Y. (2013)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6695 HGNC: 11251 AceView: SPOCK.2 Ensembl:ENSG00000152377 euGenes: HUgn6695
    ECgene: SPOCK1 H-InvDB: SPOCK1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPOCK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SPOCK1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPOCK1 gene:
    Search GeneIP for patents involving SPOCK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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