SPOCK1 Gene
protein-coding GIFtS: 56
GC05M136339
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sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 (Previous names: sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: TIC1, SPOCK)
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Aliases & Descriptions for SPOCK1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
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| FLJ37170 2 | | OTTHUMP00000159433 2 | | SPOCK 2, 3 | | TESTICAN 2 | | TIC1 2, 3 | | TICN1 3 | | testican-1 1, 2 |
| | | Descriptions |
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| Protein SPOCK 3 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 2 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 2 |
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| | Search outside databases for aliases for SPOCK1 gene |
Summaries for SPOCK1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for SPOCK1: This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq] UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629Function: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous systemGene Wiki entry for SPOCK1 |
Genomic Location for SPOCK1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SPOCK1 gene 
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.2SPOCK1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M136339:
(about GC identifiers)
Start:
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136,338,886 bp from pter |
End:
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136,862,936 bp from pter |
Size:
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524,051 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000005.8 NT_034772.5
| Proteins for SPOCK1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629 (See
protein sequence)Recommended Name: Testican-1 precursor Size: 439 amino acids; 49124 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Secondary accessions: B3KSW3 Q59EW0 Q8N630 Q9UCL8Post-translational modifications:
Contains chondroitin sulfate and heparan sulfate O-linked oligosaccharides1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004589.1
ENSEMBL proteins: ENSP00000282223 ENSP00000378401
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- | | GO:0005578 | proteinaceous extracellular matrix |
IEA | -- | About this table
Antibodies for SPOCK1: Assays for SPOCK1: | Protein
Domains/ Families for SPOCK1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q08629
ProtoNet protein and cluster: Q08629 2 Blocks protein families: IPB000716 Thyroglobulin type-1 IPB011497 Protease inhibitor
UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629Similarity: Contains 1 Kazal-like domainSimilarity: Contains 1 thyroglobulin type-1 domain | Gene Function for SPOCK1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004598
Applied Biosystems Silencer® siRNAs for SPOCK1
Sigma-Aldrich siRNA for SPOCK1  Sigma-Aldrich shRNA Panels and shRNA for SPOCK1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004598                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004598                                  untagged cDNA clone in CMV expression vector: NM_004598 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004598
UniProtKB/Swiss-Prot: TICN1_HUMAN, Q08629Function: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Spock1):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005509 | calcium ion binding |
IEA | -- | About this table | Pathways & Interactions for SPOCK1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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3 Interacting proteins for SPOCK1 (ENSP000002822233) via UniProtKB, MINT, and/or STRINGAbout this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
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Drugs & Compounds for SPOCK1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for SPOCK1
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Transcripts for SPOCK1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004598
Sigma-Aldrich siRNA for SPOCK1  Sigma-Aldrich shRNA Panels and shRNA for SPOCK1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004598 REFSEQ mRNAs for SPOCK1 gene: NM_004598.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004598               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004598                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004598                                  untagged cDNA clone in CMV expression vector: NM_004598  Additional cDNA sequence: AB209701.1 AF231124.1 AK094489.1 BC030691.2 CR606032.1 12 DOTS entries: DT.97857476 DT.95124677 DT.101967721 DT.95331642 DT.120815763 DT.100037804 DT.120815755 DT.100711206 DT.120815632 DT.100727843 DT.120815883 DT.91760126 1 AceView cDNA sequence:BI550122
highest scoring ESTs for SPOCK1:AF231124 AI674088 BC030691 X73608 AA027807 AA027861 AA035654 AA040054 AA045197 AA045381 Unigene Cluster for SPOCK1: Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 Hs.643338 [show with all ESTs]Unigene Representative Sequence: NM_004598
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000282223
ENST00000394945
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Expression for SPOCK1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SPOCK1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SPOCK1
1 / 2 / 3 4 probe-sets matching SPOCK1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AGAATACCTT
SOURCE GeneReport for Unigene cluster: Hs.643338
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Orthologs for SPOCK1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for SPOCK1 gene from 5/7 species (see all 7
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About this table Species with no ortholog for SPOCK1
ENSEMBL Gene Tree for SPOCK1 | Paralogs for SPOCK1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SPOCK1 gene
- SPOCK32 SPOCK22
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SNPs/Variants for SPOCK1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for SPOCK1 (up to first 250kb)
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Disorders & Mutations for SPOCK1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 602264
Human Genome Epidemiology Navigator: SPOCK1 (1 document)
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Medical News for SPOCK1(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for SPOCK1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/18 PubMed articles for SPOCK1 gene (see all 18
):- Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. (PubMed id 9545645)1, 2, 3 Charbonnier F....Alliel P.M. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)3, 4 Schmutz J.... Rubin E.M. (2004)
- Endothelial cell expression of testican mRNA. (PubMed id 9272383)3, 4 Marr H.S.... Edgell C.J. (1997)
- Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. (PubMed id 8389704)3, 4 Alliel P.M.... Bonnet F.J. (1993)
- Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (PubMed id 19282985)1, 3 Liu Y.Z....Deng H.W. (2009)
- Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater. (PubMed id 16596217)3 Prenzel K.L....Schneider P.M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. (PubMed id 12810672)3 Nakada M....Sato H. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
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Search for SPOCK1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing SPOCK1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
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| Other Databases showing SPOCK1
(According to HUGE)
About This Section
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Specialized Databases showing SPOCK1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Services for SPOCK1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for SPOCK1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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