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Aliases for SPOCK1 Gene

Aliases for SPOCK1 Gene

  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 1 2 3
  • SPOCK 3 4 6
  • TIC1 3 4
  • Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 2
  • Protein SPOCK 4
  • Testican-1 3
  • TESTICAN 3
  • TICN1 4

External Ids for SPOCK1 Gene

Previous HGNC Symbols for SPOCK1 Gene

  • TIC1
  • SPOCK

Previous GeneCards Identifiers for SPOCK1 Gene

  • GC05M136339
  • GC05M131500
  • GC05M136310

Summaries for SPOCK1 Gene

Entrez Gene Summary for SPOCK1 Gene

  • This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPOCK1 Gene

SPOCK1 (Sparc/Osteonectin, Cwcv And Kazal-Like Domains Proteoglycan (Testican) 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding and cysteine-type endopeptidase inhibitor activity. An important paralog of this gene is SPOCK2.

UniProtKB/Swiss-Prot for SPOCK1 Gene

  • May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system

Gene Wiki entry for SPOCK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCK1 Gene

Genomics for SPOCK1 Gene

Regulatory Elements for SPOCK1 Gene

Genomic Location for SPOCK1 Gene

Start:
136,975,298 bp from pter
End:
137,598,379 bp from pter
Size:
623,082 bases
Orientation:
Minus strand

Genomic View for SPOCK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPOCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCK1 Gene

Proteins for SPOCK1 Gene

  • Protein details for SPOCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08629-TICN1_HUMAN
    Recommended name:
    Testican-1
    Protein Accession:
    Q08629
    Secondary Accessions:
    • B3KSW3
    • Q59EW0
    • Q8N630
    • Q9UCL8

    Protein attributes for SPOCK1 Gene

    Size:
    439 amino acids
    Molecular mass:
    49124 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92938.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SPOCK1 Gene

Proteomics data for SPOCK1 Gene at MOPED

Post-translational modifications for SPOCK1 Gene

  • O-glycosylated. Glycosaminoglycan that contains chondroitin sulfate and heparan sulfate.
  • Glycosylation at Ser131, Thr228, Ser383, and Ser388
  • Modification sites at PhosphoSitePlus

Other Protein References for SPOCK1 Gene

No data available for DME Specific Peptides for SPOCK1 Gene

Domains for SPOCK1 Gene

Suggested Antigen Peptide Sequences for SPOCK1 Gene

Graphical View of Domain Structure for InterPro Entry

Q08629

UniProtKB/Swiss-Prot:

TICN1_HUMAN :
  • Q08629
Domain:
  • Contains 1 Kazal-like domain.
  • Contains 1 thyroglobulin type-1 domain.
genes like me logo Genes that share domains with SPOCK1: view

No data available for Gene Families for SPOCK1 Gene

Function for SPOCK1 Gene

Molecular function for SPOCK1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system

Gene Ontology (GO) - Molecular Function for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity NAS 14511383
GO:0004869 cysteine-type endopeptidase inhibitor activity IDA 14511383
GO:0005509 calcium ion binding IDA 9323035
GO:0005515 protein binding --
GO:0008191 metalloendopeptidase inhibitor activity IDA 11751414
genes like me logo Genes that share ontologies with SPOCK1: view

Phenotypes for SPOCK1 Gene

MGI mutant phenotypes for SPOCK1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SPOCK1: view

Animal Models for SPOCK1 Gene

MGI Knock Outs for SPOCK1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPOCK1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SPOCK1 Gene

Localization for SPOCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPOCK1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPOCK1 Gene COMPARTMENTS Subcellular localization image for SPOCK1 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IDA 14511383
GO:0005737 cytoplasm ISS --
GO:0014069 postsynaptic density NAS 9181134
GO:0016528 sarcoplasm ISS --
genes like me logo Genes that share ontologies with SPOCK1: view

Pathways for SPOCK1 Gene

genes like me logo Genes that share pathways with SPOCK1: view

Pathways by source for SPOCK1 Gene

1 BioSystems pathway for SPOCK1 Gene

Gene Ontology (GO) - Biological Process for SPOCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 8389704
GO:0001764 neuron migration ISS --
GO:0007155 cell adhesion NAS 8389704
GO:0007165 signal transduction IEA --
GO:0007399 nervous system development NAS 9181134
genes like me logo Genes that share ontologies with SPOCK1: view

Transcripts for SPOCK1 Gene

mRNA/cDNA for SPOCK1 Gene

(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPOCK1 Gene

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPOCK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCK1 Gene

No ASD Table

Relevant External Links for SPOCK1 Gene

GeneLoc Exon Structure for
SPOCK1
ECgene alternative splicing isoforms for
SPOCK1

Expression for SPOCK1 Gene

mRNA expression in normal human tissues for SPOCK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPOCK1 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.0).

Protein differential expression in normal tissues for SPOCK1 Gene

This gene is overexpressed in Vitreous humor (58.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPOCK1 Gene

SOURCE GeneReport for Unigene cluster for SPOCK1 Gene Hs.596136

genes like me logo Genes that share expressions with SPOCK1: view

Expression partners for SPOCK1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPOCK1 Gene

Orthologs for SPOCK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPOCK1 35
  • 91.34 (n)
  • 94.31 (a)
SPOCK1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPOCK1 35
  • 92.06 (n)
  • 95.77 (a)
SPOCK1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spock1 35
  • 89.75 (n)
  • 95.22 (a)
Spock1 16
Spock1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPOCK1 35
  • 99.39 (n)
  • 98.86 (a)
SPOCK1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spock1 35
  • 90.13 (n)
  • 94.76 (a)
oppossum
(Monodelphis domestica)
Mammalia SPOCK1 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPOCK1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPOCK1 35
  • 78.93 (n)
  • 85.85 (a)
SPOCK1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPOCK1 36
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100331540 35
  • 66.93 (n)
  • 69.17 (a)
SPOCK1 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13830 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C54E4.2 36
  • 29 (a)
OneToMany
Species with no ortholog for SPOCK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPOCK1 Gene

ENSEMBL:
Gene Tree for SPOCK1 (if available)
TreeFam:
Gene Tree for SPOCK1 (if available)

Paralogs for SPOCK1 Gene

Paralogs for SPOCK1 Gene

Selected SIMAP similar genes for SPOCK1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SPOCK1: view

Variants for SPOCK1 Gene

Sequence variations from dbSNP and Humsavar for SPOCK1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs17499 -- 137,492,771(+) TTGGA(C/G)CATGT intron-variant
rs25429 -- 137,137,138(+) CTGCT(C/T)GCAAA intron-variant
rs713583 -- 137,081,395(+) ACAGA(C/T)ACTAG intron-variant
rs713584 -- 137,081,268(+) CCTAC(A/G)GAGAC intron-variant
rs714433 -- 137,289,893(-) CTATG(A/G)GTATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCK1 Gene

Variant ID Type Subtype PubMed ID
esv2677084 CNV Deletion 23128226
nsv882933 CNV Loss 21882294
nsv830497 CNV Loss 17160897
nsv462459 CNV Loss 19166990
esv270705 CNV Insertion 20981092
nsv328026 CNV Insertion 16902084
esv1973589 CNV Deletion 18987734
esv2657276 CNV Deletion 23128226
nsv830498 CNV Gain 17160897
esv2661840 CNV Deletion 23128226
nsv5020 CNV Loss 18451855
nsv515019 CNV Complex 21397061

Relevant External Links for SPOCK1 Gene

HapMap Linkage Disequilibrium report
SPOCK1
Human Gene Mutation Database (HGMD)
SPOCK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCK1 Gene

Disorders for SPOCK1 Gene

Relevant External Links for SPOCK1

Genetic Association Database (GAD)
SPOCK1
Human Genome Epidemiology (HuGE) Navigator
SPOCK1

No disorders were found for SPOCK1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPOCK1 Gene

Publications for SPOCK1 Gene

  1. Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31. (PMID: 9545645) Charbonnier F. … Alliel P.M. (Genomics 1998) 2 3 23
  2. Genome-wide association analyses identify SPOCK as a key novel gene underlying age at menarche. (PMID: 19282985) Liu Y.Z. … Deng H.W. (PLoS Genet. 2009) 3 23 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J. … Rubin E.M. (Nature 2004) 3 4
  5. Endothelial cell expression of testican mRNA. (PMID: 9272383) Marr H.S. … Edgell C.J. (Endothelium 1997) 3 4

Products for SPOCK1 Gene

Sources for SPOCK1 Gene

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