Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPOCD1 Gene

Aliases for SPOCD1 Gene

  • SPOC Domain Containing 1 2 3
  • Protein Phosphatase 1, Regulatory Subunit 146 3
  • SPOC Domain-Containing Protein 1 3
  • Regulatory Subunit 146 2
  • Protein Phosphatase 1 2
  • PPP1R146 3

External Ids for SPOCD1 Gene

Previous GeneCards Identifiers for SPOCD1 Gene

  • GC01M031926
  • GC01M032028
  • GC01M032256
  • GC01M030373

Summaries for SPOCD1 Gene

Entrez Gene Summary for SPOCD1 Gene

  • This gene encodes a protein that belongs to the TFIIS family of transcription factors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

GeneCards Summary for SPOCD1 Gene

SPOCD1 (SPOC Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is DIDO1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPOCD1 Gene

Genomics for SPOCD1 Gene

Genomic Location for SPOCD1 Gene

31,790,422 bp from pter
31,816,051 bp from pter
25,630 bases
Minus strand

Genomic View for SPOCD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPOCD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPOCD1 Gene

No data available for Regulatory Elements for SPOCD1 Gene

Proteins for SPOCD1 Gene

  • Protein details for SPOCD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    SPOC domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q24JU3
    • Q6PI90
    • Q8N869
    • Q8N8U0
    • Q8NBC6
    • Q96LN6

    Protein attributes for SPOCD1 Gene

    1216 amino acids
    Molecular mass:
    130027 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH39870.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71652.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04981.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SPOCD1 Gene


neXtProt entry for SPOCD1 Gene

Proteomics data for SPOCD1 Gene at MOPED

Post-translational modifications for SPOCD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPOCD1 Gene

Domains for SPOCD1 Gene

Protein Domains for SPOCD1 Gene


Suggested Antigen Peptide Sequences for SPOCD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6ZMY3
  • Contains 1 SPOC domain.
  • Contains 1 TFIIS central domain.
genes like me logo Genes that share domains with SPOCD1: view

No data available for Gene Families for SPOCD1 Gene

Function for SPOCD1 Gene

Gene Ontology (GO) - Molecular Function for SPOCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with SPOCD1: view

Animal Model Products

CRISPR Products

miRNA for SPOCD1 Gene

miRTarBase miRNAs that target SPOCD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SPOCD1 Gene

Localization for SPOCD1 Gene

Subcellular locations from

Jensen Localization Image for SPOCD1 Gene COMPARTMENTS Subcellular localization image for SPOCD1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for SPOCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
genes like me logo Genes that share ontologies with SPOCD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SPOCD1 Gene

Pathways for SPOCD1 Gene

SuperPathways for SPOCD1 Gene

No Data Available

Interacting Proteins for SPOCD1 Gene

Gene Ontology (GO) - Biological Process for SPOCD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0010923 negative regulation of phosphatase activity IDA 19389623
genes like me logo Genes that share ontologies with SPOCD1: view

No data available for Pathways by source for SPOCD1 Gene

Transcripts for SPOCD1 Gene

Unigene Clusters for SPOCD1 Gene

SPOC domain containing 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPOCD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SPOCD1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPOCD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - -
SP5: - - - - - - - - - -
SP6: - - - - - -
SP7: - -
SP8: - - - -
SP9: - - - - -
SP10: - - - -
SP12: - - -
SP13: - -
SP15: -

ExUns: 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: -
SP3: - - - -

Relevant External Links for SPOCD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPOCD1 Gene

mRNA expression in normal human tissues for SPOCD1 Gene

mRNA differential expression in normal tissues according to GTEx for SPOCD1 Gene

This gene is overexpressed in Testis (5.8) and Bladder (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPOCD1 Gene

SOURCE GeneReport for Unigene cluster for SPOCD1 Gene Hs.62604

genes like me logo Genes that share expressions with SPOCD1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SPOCD1 Gene

Orthologs for SPOCD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPOCD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPOCD1 35
  • 99 (n)
  • 98.17 (a)
  • 96 (a)
(Bos Taurus)
Mammalia SPOCD1 35
  • 76.28 (n)
  • 62.59 (a)
  • 55 (a)
(Canis familiaris)
Mammalia SPOCD1 35
  • 79.37 (n)
  • 69.75 (a)
  • 67 (a)
(Mus musculus)
Mammalia Spocd1 35
  • 68.4 (n)
  • 55.76 (a)
Spocd1 16
Spocd1 36
  • 58 (a)
(Monodelphis domestica)
Mammalia SPOCD1 36
  • 22 (a)
(Ornithorhynchus anatinus)
Mammalia SPOCD1 36
  • 21 (a)
(Rattus norvegicus)
Mammalia Spocd1 35
  • 73.5 (n)
  • 59.83 (a)
(Anolis carolinensis)
Reptilia SPOCD1 36
  • 28 (a)
fruit fly
(Drosophila melanogaster)
Insecta pps 36
  • 7 (a)
Species with no ortholog for SPOCD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPOCD1 Gene

Gene Tree for SPOCD1 (if available)
Gene Tree for SPOCD1 (if available)

Paralogs for SPOCD1 Gene

Paralogs for SPOCD1 Gene

Selected SIMAP similar genes for SPOCD1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with SPOCD1: view

Variants for SPOCD1 Gene

Sequence variations from dbSNP and Humsavar for SPOCD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs12384 -- 31,790,565(-) GCCCT(C/T)ACTAG utr-variant-3-prime
rs13426 -- 31,790,485(-) TTTGA(A/G)CTTCC utr-variant-3-prime
rs552124 -- 31,800,425(+) ATGAC(A/G)TCACT intron-variant
rs751137 -- 31,812,707(-) TATTG(G/T)GCTAA intron-variant
rs2184202 -- 31,811,598(+) TTGAA(A/C)CTGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPOCD1 Gene

Variant ID Type Subtype PubMed ID
dgv46e1 CNV Complex 17122850
esv2517616 CNV Insertion 19546169
nsv870880 CNV Gain 21882294
nsv822242 CNV Loss 20364138
esv260047 OTHER Complex 20981092
nsv160616 CNV Insertion 16902084

Relevant External Links for SPOCD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPOCD1 Gene

Disorders for SPOCD1 Gene

No disorders were found for SPOCD1 Gene.

No data available for UniProtKB/Swiss-Prot for SPOCD1 Gene

Publications for SPOCD1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A. … Bollen M. (Chem. Biol. 2009) 3
  5. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3

Products for SPOCD1 Gene

Sources for SPOCD1 Gene

Back to Top