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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPOCD1 Gene

protein-coding GIFtS: 44
GCID: GC01M032256

SPOC domain containing 1

Search for SPOCD1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
SPOC Domain Containing 1¹ ²
FLJ25348¹
SPOC Domain-Containing Protein 1²

External Ids:	HGNC: 26338¹	Entrez Gene: 90853²	Ensembl: ENSG00000134668⁷	UniProtKB: Q6ZMY3³

Export aliases for SPOCD1 gene to outside databases

Previous GC identifers: GC01M031926 GC01M032028 GC01M030373

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_032977.9

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for SPOCD1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SPOCD1 promoter sequence

Search SABiosciences Chromatin IP Primers for SPOCD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOCD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.2 Ensembl cytogenetic band: 1p35.2 HGNC cytogenetic band: 1p35.1

SPOCD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPOCD1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M032256: view genomic region (about GC identifiers)

Start:	32,256,023 bp from pter	End:	32,281,652 bp from pter
Size:	25,630 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPOC1_HUMAN, Q6ZMY3 (See protein sequence)

Recommended Name: SPOC domain-containing protein 1

Size: 1216 amino acids; 130027 Da

Sequence caution: Sequence=AAH39870.1; Type=Erroneous initiation; Sequence=BAB71652.1; Type=Erroneous initiation;

Sequence=BAC04981.1; Type=Erroneous initiation;

Secondary accessions: Q24JU3 Q6PI90 Q8N869 Q8N8U0 Q8NBC6 Q96LN6

Alternative splicing: 5 isoforms: Q6ZMY3-1 Q6ZMY3-2 Q6ZMY3-3 Q6ZMY3-4 Q6ZMY3-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPOCD1: NX_Q6ZMY3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZMY3

SPOCD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653170.3

ENSEMBL proteins:

ENSP00000257100 ENSP00000353670 ENSP00000399778 ENSP00000435851 ENSP00000437197

ENSP00000437270 ENSP00000435385 ENSP00000436239 ENSP00000362752

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPOCD1 for domains About GeneDecksing

2 InterPro domains/families:

IPR003618 TFIIS_cen_dom

IPR012921 SPOC_C

Graphical View of Domain Structure for InterPro Entry Q6ZMY3

ProtoNet protein and cluster: Q6ZMY3

1 Blocks protein family: IPB012921 SPOC

UniProtKB/Swiss-Prot: SPOC1_HUMAN, Q6ZMY3

Similarity: Contains 1 SPOC domain

Similarity: Contains 1 TFIIS central domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
Products:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPOCD1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for SPOCD1 (ENSP00000353670⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPP1CA	ENSP00000326031⁴	STRING: ENSP00000326031
PPP1CC	ENSP00000335084⁴	STRING: ENSP00000335084

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006351	transcription, DNA-dependent	IEA	--
GO:0010923	negative regulation of phosphatase activity	IDA	19389623

SPOCD1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPOCD1
Search CenterWatch for drugs/clinical trials and news about SPOCD1 / SPOC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPOCD1 gene:

NM_144569.4

Unigene Cluster for SPOCD1:

SPOC domain containing 1

Hs.62604 [show with all ESTs]

Unigene Representative Sequence: AK131447

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000257100(uc001btv.3) ENST00000360482(uc001bts.1 uc001btu.3)

ENST00000473361 ENST00000452755(uc021oks.1) ENST00000533231 ENST00000528579

ENST00000532604 ENST00000531039 ENST00000468720 ENST00000460061(uc001btw.1)

ENST00000485944 ENST00000529396 ENST00000528791 ENST00000525930 ENST00000373648

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Additional cDNA sequence:

AK058077.1 AK091016.1 AK095829.1 AK096192.1 AK097227.1 AK131447.1 BC007910.2 BC029069.1

BC039870.2 BC069257.1 BC098449.1 BC114430.1

12 DOTS entries:

DT.121407847 DT.97808670 DT.100679943 DT.95365300 DT.99963133 DT.95291690 DT.100742799 DT.97790620

DT.409331 DT.91945068 DT.40240721 DT.100737269

24/66 AceView cDNA sequences (see all 66):

BP369215 CA309202 AK091016 CF127814 BQ670678 CK822830 BC069257 AK131447

BQ102464 NM_144569 BP336145 CA422117 AK058077 CD368884 CR600020 CK000466

BM708509 AX746730 BQ932372 BC007910 AA115931 AA364961 AK096192 BX281993

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for SPOCD1 (see all 15) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	·	9g	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	^
SP1:							-		-		-										-						-		-		-		-		-		-										-				-
SP2:																					-						-		-		-		-		-		-										-				-
SP3:																																															-				-
SP4:																																															-				-
SP5:															-		-				-				-		-		-		-		-		-		-

ExUns:	13a	·	13b	·	13c	^	14	^	15a	·	15b	^	16	^	17	^	18a	·	18b
SP1:																	-
SP2:
SP3:					-		-								-		-
SP4:
SP5:

ECgene alternative splicing isoforms for SPOCD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPOCD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCACCAGC

About this image

SPOCD1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPOCD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPOCD1

SOURCE GeneReport for Unigene cluster: Hs.62604

SABiosciences Custom PCR Arrays for SPOCD1

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPOCD1 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	SPOCD1⁶	--	35(a)	1 ↔ 1	GL343308.1(1347511-1355850)
fruit fly (Drosophila melanogaster)	Insecta	pps⁶	protein partner of snf	8(a)	possible ortholog	3R(8239550-8246973)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G29639⁶ AT2G25640⁶ (see all 4)	uncharacterized protein SPOC domain / Transcription elongation factor S-II... (see all 4)	6(a) 13(a) (see all 4)	many ↔ many many ↔ many (see all 4)	3(11478732-11479749) 2(10910498-10913969)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	transcription factor S-II, central domain containi... SPOC domain containing protein, putative, expresse... (see all 3)	9(a) 8(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(6083116-6089638) 6(23441842-23448456)

ENSEMBL Gene Tree for SPOCD1 (if available)
TreeFam Gene Tree for SPOCD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPOCD1 gene

DIDO1² PHF3²

2 SIMAP similar genes for SPOCD1 using alignment to 9 protein entries: SPOC1_HUMAN (see all proteins):

TCEA2 PHF3

SPOCD1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75941036^1,2		--	32255672(+)	`TATTAA/GCTGAA`	1	--	ds500¹		0	--	--	--	--
rs117346892^1,2	F,	--	32255785(+)	`ACCCCC/TAACCT`	1	--	ds500¹		1		EA	120
rs111550346^1,2	C,	--	32255792(+)	`ACCTCG/AGTCCT`	1	--	ds500¹		1		NA	2
rs57926157^1,2	C,F,	--	32255880(+)	`GCTGTG/ACCCTG`	1	--	ds500¹		4		WA CSA	124
rs138946336^1,2		--	32255910(+)	`GACCTC/TAGACC`	1	--	ds500¹		0	--	--	--	--
rs191416825^1,2		--	32256065(+)	`AACAGC/GAAACA`	1	--	ut3¹		0	--	--	--	--
rs41263979^1,2	C,	--	32256080(+)	`CAAACG/AGGAAG`	1	--	ut3¹		1		NA	2
rs184225320^1,2	C,	--	32256302(+)	`AAGGGC/TGCTAG`	2	T A	mis¹		0	--	--	--	--
rs190724853^1,2	C,	--	32256303(+)	`AGGGCA/GCTAGA`	2	S	syn¹		0	--	--	--	--
rs36047547^1,2	C,F,	--	32256329(-)	`CCATCC/TCCCGC`	2	P S	mis¹		3		NA	2480

HapMap Linkage Disequilibrium report for SPOCD1 (32256023 - 32281652 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for SPOCD1
3 CNVs: 97328 2304 3287

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QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPOCD1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPOCD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPOCD1)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)¹ Hendrickx A.... Bollen M. (2009)
The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)² Sjoeblom T.... Velculescu V.E. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 90853	HGNC: 26338	AceView: SPOCD1	Ensembl:ENSG00000134668	euGenes: HUgn90853
ECgene: SPOCD1	H-InvDB: SPOCD1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPOCD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPOCD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPOCD1 gene:
Search GeneIP for patents involving SPOCD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for SPOCD1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPOCD1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPOCD1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPOCD1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPOCD1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPOCD1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPOCD1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPOCD1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPOCD1

	GenScript Custom Purified and Recombinant Proteins Services for SPOCD1		GenScript cDNA clones with any tag delivered in your preferred vector for SPOCD1
	GenScript Custom Assay Services for SPOCD1		GenScript Custom Superior Antibodies Services for SPOCD1
	GenScript Custom overexpressing Cell Line Services for SPOCD1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPOCD1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPOCD1 gene at Home site.

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SPOCD1 Gene

SPOC domain containing 1

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SPOCD1 Gene

SPOC domain containing 1

Aliasesfor SPOCD1 gene

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Genomic Viewsfor SPOCD1 gene

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for SPOCD1 gene

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