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Aliases for SPO11 Gene

Aliases for SPO11 Gene

  • SPO11 Meiotic Protein Covalently Bound To DSB 2 3
  • Cancer/Testis Antigen 35 2 3 4
  • Spermatogenesis Associated 43 2 3
  • CT35 3 4
  • SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae) 2
  • SPO11, Meiotic Protein Covalently Bound To DSB (S. Cerevisiae)-Like 2
  • SPO11 Meiotic Protein Covalently Bound To DSB-Like (S. Cerevisiae) 2
  • SPO11 Meiotic Protein Covalently Bound To DSB Homolog 3
  • Meiotic Recombination Protein SPO11 3
  • SPATA43 3
  • TOPVIA 3

External Ids for SPO11 Gene

Summaries for SPO11 Gene

Entrez Gene Summary for SPO11 Gene

  • Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPO11 Gene

SPO11 (SPO11 Meiotic Protein Covalently Bound To DSB) is a Protein Coding gene. Among its related pathways are Meiosis and Meiosis. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for SPO11 Gene

  • Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPO11 Gene

Genomics for SPO11 Gene

Genomic Location for SPO11 Gene

Start:
57,329,759 bp from pter
End:
57,343,994 bp from pter
Size:
14,236 bases
Orientation:
Plus strand

Genomic View for SPO11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPO11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPO11 Gene

Regulatory Elements for SPO11 Gene

Proteins for SPO11 Gene

  • Protein details for SPO11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5K1-SPO11_HUMAN
    Recommended name:
    Meiotic recombination protein SPO11
    Protein Accession:
    Q9Y5K1
    Secondary Accessions:
    • Q5TCI1
    • Q8N4V0
    • Q9NQM7
    • Q9NQM8

    Protein attributes for SPO11 Gene

    Size:
    396 amino acids
    Molecular mass:
    44537 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPO11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPO11 Gene

Proteomics data for SPO11 Gene at MOPED

Post-translational modifications for SPO11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPO11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SPO11 Gene

Domains for SPO11 Gene

UniProtKB/Swiss-Prot:

SPO11_HUMAN
Family:
  • Belongs to the TOP6A family.:
    • Q9Y5K1
genes like me logo Genes that share domains with SPO11: view

No data available for Gene Families for SPO11 Gene

Function for SPO11 Gene

Molecular function for SPO11 Gene

GENATLAS Biochemistry: Yeast meiosis specific gene homolog,required for double strand break formation required for initiation of recombination in S cerevisiae,expressed in prostate,testis,? and other tissues with an alternatively spliced isoform.
UniProtKB/Swiss-Prot Function: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).

Gene Ontology (GO) - Molecular Function for SPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003824 catalytic activity --
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SPO11: view
genes like me logo Genes that share phenotypes with SPO11: view

Animal Models for SPO11 Gene

MGI Knock Outs for SPO11:

miRNA for SPO11 Gene

miRTarBase miRNAs that target SPO11

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPO11 Gene

Localization for SPO11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPO11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPO11 Gene COMPARTMENTS Subcellular localization image for SPO11 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome --
genes like me logo Genes that share ontologies with SPO11: view

Pathways for SPO11 Gene

SuperPathways for SPO11 Gene

Superpath Contained pathways
1 Meiosis
.74
genes like me logo Genes that share pathways with SPO11: view

Pathways by source for SPO11 Gene

2 Reactome pathways for SPO11 Gene

Interacting Proteins for SPO11 Gene

Gene Ontology (GO) - Biological Process for SPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000737 DNA catabolic process, endonucleolytic IEA --
GO:0001541 ovarian follicle development IEA --
GO:0006259 DNA metabolic process --
GO:0007129 synapsis IEA --
GO:0007131 reciprocal meiotic recombination IEA --
genes like me logo Genes that share ontologies with SPO11: view

Transcripts for SPO11 Gene

mRNA/cDNA for SPO11 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPO11 Gene

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPO11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -

Relevant External Links for SPO11 Gene

GeneLoc Exon Structure for
SPO11
ECgene alternative splicing isoforms for
SPO11

Expression for SPO11 Gene

mRNA expression in normal human tissues for SPO11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPO11 Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPO11 Gene

SOURCE GeneReport for Unigene cluster for SPO11 Gene Hs.159737

mRNA Expression by UniProt/SwissProt for SPO11 Gene

Q9Y5K1-SPO11_HUMAN
Tissue specificity: Highly expressed in testis
genes like me logo Genes that share expressions with SPO11: view

Orthologs for SPO11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPO11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPO11 36
  • 99.41 (n)
  • 98.99 (a)
SPO11 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPO11 36
  • 89.45 (n)
  • 90.38 (a)
SPO11 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPO11 36
  • 90.57 (n)
  • 90.4 (a)
SPO11 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spo11 36
  • 81.9 (n)
  • 82.58 (a)
Spo11 16
Spo11 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPO11 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPO11 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spo11 36
  • 81.22 (n)
  • 83.54 (a)
chicken
(Gallus gallus)
Aves SPO11 36
  • 75.45 (n)
  • 73.37 (a)
zebrafish
(Danio rerio)
Actinopterygii spo11 36
  • 59.98 (n)
  • 60.16 (a)
spo11 37
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010898 36
  • 46.03 (n)
  • 38.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta mei-W68 36
  • 46.08 (n)
  • 36.49 (a)
mei-W68 37
  • 34 (a)
OneToOne
mei-W68 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea spo-11 37
  • 25 (a)
OneToOne
spo-11 38
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPO11 39
thale cress
(Arabidopsis thaliana)
eudicotyledons RHL2 36
  • 48.38 (n)
  • 37.71 (a)
rice
(Oryza sativa)
Liliopsida Os03g0284800 36
  • 44.32 (n)
  • 36.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for SPO11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPO11 Gene

ENSEMBL:
Gene Tree for SPO11 (if available)
TreeFam:
Gene Tree for SPO11 (if available)

Paralogs for SPO11 Gene

No data available for Paralogs for SPO11 Gene

Variants for SPO11 Gene

Sequence variations from dbSNP and Humsavar for SPO11 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1467581 -- 57,341,298(+) cctta(A/G)ttagt intron-variant
rs2236330 -- 57,342,958(+) CTAAC(A/G)TAAGT intron-variant, downstream-variant-500B
rs3067144 -- 57,327,889(+) AAAAA(-/A)GTTCA upstream-variant-2KB
rs3736832 - 57,333,213(+) TTCAG(A/G)TGGTA reference, missense, nc-transcript-variant
rs3764674 -- 57,335,486(-) CCAAA(A/C)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPO11 Gene

Variant ID Type Subtype PubMed ID
nsv459027 CNV Loss 19166990

Relevant External Links for SPO11 Gene

HapMap Linkage Disequilibrium report
SPO11

Disorders for SPO11 Gene

Relevant External Links for SPO11

Genetic Association Database (GAD)
SPO11
Human Genome Epidemiology (HuGE) Navigator
SPO11
genes like me logo Genes that share disorders with SPO11: view

No data available for UniProtKB/Swiss-Prot for SPO11 Gene

Publications for SPO11 Gene

  1. Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis. (PMID: 10622720) Shannon M. … Thelen M.P. (FEBS Lett. 1999) 3 4 23
  2. Cloning, characterization, and localization of mouse and human SPO11. (PMID: 10534401) Romanienko P.J. … Camerini-Otero R.D. (Genomics 1999) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Screening the SPO11 and EIF5A2 genes in a population of infertile men. (PMID: 16169419) Christensen G.L. … Carrell D.T. (Fertil. Steril. 2005) 3 49
  5. Genetic investigation of four meiotic genes in women with premature ovarian failure. (PMID: 18166824) Mandon-PAcpin B. … Fellous M. (Eur. J. Endocrinol. 2008) 3 49

Products for SPO11 Gene

Sources for SPO11 Gene

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