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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPO11 Gene

protein-coding   GIFtS: 54
GCID: GC20P055905

SPO11 meiotic protein covalently bound to DSB homolog (S....

(Previous names: SPO11, meiotic protein covalently bound to DSB (S. cerevisiae)-like,...)
 Explore 8 diseases affiliated with
SPO11 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPO11    

Aliases
for SPO11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae)1 2
CT351 2 3
Cancer/Testis Antigen 352 3
SPO11 Meiotic Protein Covalently Bound To DSB-Like (S. Cerevisiae)1
SPO11, Meiotic Protein Covalently Bound To DSB (S. Cerevisiae)-Like1
Meiotic Recombination Protein SPO112

External Ids:    HGNC: 112501   Entrez Gene: 236262   Ensembl: ENSG000000547967   OMIM: 6051145   UniProtKB: Q9Y5K13   

Export aliases for SPO11 gene to outside databases

Previous GC identifers: GC20P055633 GC20P056543 GC20P056590 GC20P055338 GC20P052686


Summaries
for SPO11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPO11:
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired
chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of
DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved
features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several
transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two
of them have been described. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1
Function: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that
initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By
similarity)




Genomic Views
for SPO11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPO11 gene promoter:
         CUTL1   POU6F1 (c2)   IRF-1   E4BP4   Roaz   E47   HNF-1   MRF-2   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPO11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPO11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPO11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31

SPO11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPO11 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P055905:  view genomic region     (about GC identifiers)

Start:
 55,904,815 bp from pter      End:
 55,919,050 bp from pter
Size:
 14,236 bases      Orientation:
 plus strand

Proteins
for SPO11 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1 (See protein sequence)
Recommended Name: Meiotic recombination protein SPO11  
Size: 396 amino acids; 44537 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5TCI1 Q8N4V0 Q9NQM7 Q9NQM8
Alternative splicing: 2 isoforms:  Q9Y5K1-1   Q9Y5K1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPO11: NX_Q9Y5K1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y5K1

    • SPO11 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_036576.1  NP_937998.1  

    ENSEMBL proteins: 
     ENSP00000360310   ENSP00000316034   ENSP00000360307   ENSP00000413185   ENSP00000431842  
    Reactome Protein details: Q9Y5K1
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): SPO11
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    Novus Biologicals SPO11 Proteins
    Novus Biologicals SPO11 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPO11

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IEA--
    GO:0005634nucleus IEA--
    GO:0005694chromosome ----


    SPO11 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for SPO11

    Protein Domains /
    Families
    for SPO11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SPO11 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR011991 WHTH_trsnscrt_rep_DNA-bd_dom
     IPR013049 Spo11/TopoVI_A_N
     IPR013048 Meiotic_Spo11
     IPR004084 Meiosis_Spo11
     IPR002815 Spo11/TopoVI_A

    Graphical View of Domain Structure for InterPro Entry Q9Y5K1

    ProtoNet protein and cluster: Q9Y5K1

    2 Blocks protein families:
    IPB013048 SPO11 homologue signature
    IPB013049 DNA topoisomerase


    UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1
    Similarity: Belongs to the TOP6A family


    Function
    for SPO11 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1
    Function: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that
    initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By
    similarity)

         Genatlas biochemistry entry for SPO11:
    Yeast meiosis specific gene homolog,required for double strand break formation required for initiation of recombination
    in S cerevisiae,expressed in prostate,testis,? and other tissues with an alternatively spliced isoform.

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPO11
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    hsa-miR-374b hsa-miR-3143 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: SPO11 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SPO11
    OriGene siRNA: SPO11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPO11

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPO11 

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    Search LifeMap BioReagents cell lines for SPO11

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0005524ATP binding IEA--
    GO:0016787hydrolase activity IEA--


    SPO11 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for SPO11: Spo11tm1Mjn Spo11tm1Rdco
         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Spo11):
     endocrine/exocrine gland  immune system  reproductive system 

    SPO11 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SPO11 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiotic Synapsis
    		Meiosis0.70
    		Meiotic Recombination0.32
    2Meiosis
    		Meiosis1.00
    3Recruitment of repair and signaling proteins to double-strand breaks
    		Removal of SPO11 and Resection of 5' Ends of DNA0.30

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SPO11
        Meiosis


    3        Reactome Pathways for SPO11
        Meiosis
    Meiotic Recombination
    Removal of SPO11 and Resection of 5' Ends of DNA



    SPO11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPO11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/24 Interacting proteins for SPO11 (Q9Y5K13 ENSP000003603104) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSU72Q9NP773I2D: score=2 
    DEAF1O753983I2D: score=1 
    POLR2CP193873I2D: score=1 
    RBL1P287493I2D: score=1 
    RPS3P233963I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000238zygotene IEA--
    GO:0001541ovarian follicle development IEA--
    GO:0006259DNA metabolic process ----
    GO:0007131reciprocal meiotic recombination IEA--
    GO:0007141male meiosis I IEA--


    SPO11 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPO11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPO11
    Search CenterWatch for drugs/clinical trials and news about SPO11 

    Transcripts
    for SPO11 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPO11 gene (2 alternative transcripts): 
    NM_012444.2  NM_198265.1  

    Unigene Cluster for SPO11:

    SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
    Hs.159737  [show with all ESTs]
    Unigene Representative Sequence: AF169385
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371263(uc002xye.3 uc002xyf.3) ENST00000345868 ENST00000371260
    ENST00000418127 ENST00000494972

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPO11
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SPO11:
    hsa-miR-374b hsa-miR-3143 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: SPO11 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: SPO11
    OriGene siRNA: SPO11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPO11
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPO11 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): SPO11 (NM_198265)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPO11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPO11

    Additional cDNA sequence: 

    AF149310.1 AF169385.1 BC033591.1 

    2 DOTS entries:

    DT.101980571  DT.100748264 

    11 AceView cDNA sequences:

    BX091792 BG183224 BC033591 NM_198265 NM_012444 AF149310 BG188132 BI826715 
    AF169385 BI827785 AI393442 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPO11    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                        -           -                                             
    SP2:              -                                         -           -                                             
    SP3:                                                                                -     -                           
    SP4:                                                              -     -                                             


    ECgene alternative splicing isoforms for SPO11

    Expression
    for SPO11 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPO11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATTTTGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SPO11 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordOogoniaFemale Gametocytes, Germ Cells
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    TestisSeminiferous TubulesPrimary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SPO11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPO11

    SOURCE GeneReport for Unigene cluster: Hs.159737

    UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1
    Tissue specificity: Highly expressed in testis

        SABiosciences Custom PCR Arrays for SPO11
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    In Situ
    Assay Products:     
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    Orthologs
    for SPO11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPO11 gene from 7/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Spo111 , 5 sporulation protein, meiosis-specific, SPO11 homolog more5
    SPO11 meiotic protein covalently bound to DSB homolog more1    		 81.9(n)1
    82.58(a)1    		   2 (95.64 cM)5
    269721  NM_012046.21  NP_036176.11 
     1729777005 
    chicken
    (Gallus gallus)    		 Aves SPO111 SPO11 meiotic protein covalently bound to DSB homolog more 75.45(n)
    73.37(a)    		   768915  XM_001232075.2  XP_001232076.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii spo111 SPO11 meiotic protein covalently bound to DSB homolog more 59.98(n)
    60.16(a)    		   402982  NM_205682.1  NP_991245.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mei-W681 , 3 meiotic recombination DNA topoisomerase
    (ATP-hydrolyzing)3
    meiotic W681    		 35(a)3
    46.01(n)1
    36.27(a)1    		   23
    27688531  NM_206179.11  NP_995901.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea spo-113   -- 32(a)   IV(11123334-11124910)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RHL21 DNA topoisomerase 6 subunit A 48.38(n)
    37.71(a)    		   831314  NM_120360.3  NP_195902.1 
    rice
    (Oryza sativa)    		 Liliopsida Os03g02848001 hypothetical protein 44.32(n)
    36.68(a)    		   4332470  NM_001056300.1  NP_001049765.2 


    ENSEMBL Gene Tree for SPO11 (if available)
    TreeFam Gene Tree for SPO11 (if available) 

    Paralogs
    for SPO11 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SPO11 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/307 NCBI SNPs in SPO11 are shown (see all 307)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs75094231,2
    		C,--55902866(+) ggagaC/Ttgcag 2 -- us2k1 tfbs30--------
    rs1169793061,2
    		--55902987(+) GGCTCC/TGAGCT 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1513031061,2
    		--55903167(+) GTGAAA/CAGAGG 2 -- us2k10--------
    rs1931973351,2
    		--55903171(+) ACAGAG/TGGAGT 2 -- us2k10--------
    rs1162594001,2
    		F,--55903234(+) GGAACG/AGAAAG 2 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1405729121,2
    		--55903497(+) GAGGAA/GCTACA 2 -- us2k10--------
    rs1851691211,2
    		--55903636(+) AGCAAC/TTCCTG 2 -- us2k10--------
    rs1907553521,2
    		--55903702(+) AAATCA/TGGTAC 2 -- us2k10--------
    rs283680591,2
    		C,--55903708(+) GGTACA/GACTCC 2 -- us2k16Minor allele frequency- G:0.01NS EA 288
    rs347035601,2
    		C--55903964(+) AACTAT/-TTTTT 2 -- us2k12Minor allele frequency- -:0.25NA 4

    HapMap Linkage Disequilibrium report for SPO11 (55904815 - 55919050 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SPO11: --

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    Disorders / Diseases
    for SPO11 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPO11 for disorders           About GeneDecksing

    OMIM gene information: 605114    OMIM disorders: --

    8 diseases for SPO11:    About MalaCards
    premature ovarian failure    male infertility    infertility    azoospermia
    conjunctivitis    melanoma    malaria    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: SPO11 (4 documents)

    Export disorders for SPO11 gene to outside databases

    Publications
    for SPO11 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPO11 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SPO11)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization, and localization of mouse and human SPO11. (PubMed id 10534401)1, 2, 3 Romanienko P.J. and Camerini-Otero R.D. (1999)
    2. Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis. (PubMed id 10622720)1, 2, 9 Shannon M.... Thelen M.P. (1999)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    5. An association study of SPO11 gene single nucleotide p olymorphisms with idiopathic male infertility in Chinese Han population. (PubMed id 21556891)1 Zhang J....Tian Z. (2011)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1 Aston K.I....Carrell D.T. (2010)
    8. Genetic investigation of four meiotic genes in women with premature ovarian failure. (PubMed id 18166824)1 Mandon-Pepin B....Fellous M. (2008)
    9. Screening the SPO11 and EIF5A2 genes in a population of infertile men. (PubMed id 16169419)1 Christensen G.L....Carrell D.T. (2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for SPO11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing SPO11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23626 HGNC: 11250 AceView: SPO11 Ensembl:ENSG00000054796 euGenes: HUgn23626
    ECgene: SPO11 H-InvDB: SPO11

    Other Databases showing SPO11 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPO11 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPO11 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/spo11/

    Intellectual Property
    for SPO11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPO11 gene:
    Search GeneIP for patents involving SPO11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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