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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPO11 Gene

protein-coding   GIFtS: 57
GCID: GC20P055905

SPO11 Meiotic Protein Covalently Bound To DSB

(Previous names: SPO11, meiotic protein covalently bound to DSB (S. cerevisiae)-like,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
SPO11 Meiotic Protein Covalently Bound To DSB1 2     SPO11, Meiotic Protein Covalently Bound To DSB (S. Cerevisiae)-Like1
Cancer/Testis Antigen 351 2 3     SPATA432
Spermatogenesis Associated 431 2     TOPVIA2
CT352 3     Meiotic Recombination Protein SPO112
SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae)1     SPO11 Meiotic Protein Covalently Bound To DSB Homolog2
SPO11 Meiotic Protein Covalently Bound To DSB-Like (S. Cerevisiae)1     

External Ids:    HGNC: 112501   Entrez Gene: 236262   Ensembl: ENSG000000547967   OMIM: 6051145   UniProtKB: Q9Y5K13   

Export aliases for SPO11 gene to outside databases

Previous GC identifers: GC20P055633 GC20P056543 GC20P056590 GC20P055338 GC20P052686


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPO11 Gene:
Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired
chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end
of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and
conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein
family. Several transcript variants encoding different isoforms have been found for this gene, but the
full-length nature of only two of them have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for SPO11 Gene: 
SPO11 (SPO11 meiotic protein covalently bound to DSB) is a protein-coding gene. Diseases associated with SPO11 include premature ovarian failure, and male infertility, and among its related super-pathways are Meiosis. GO annotations related to this gene include hydrolase activity and ATP binding.

UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1
Function: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that
initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2
(By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPO11 gene promoter:
         CUTL1   POU6F1 (c2)   IRF-1   E4BP4   Roaz   E47   HNF-1   MRF-2   NF-kappaB1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPO11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SPO11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPO11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31

SPO11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPO11 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P055905:  view genomic region     (about GC identifiers)

Start:
55,904,815 bp from pter      End:
55,919,050 bp from pter
Size:
14,236 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1 (See protein sequence)
Recommended Name: Meiotic recombination protein SPO11  
Size: 396 amino acids; 44537 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q5TCI1 Q8N4V0 Q9NQM7 Q9NQM8
Alternative splicing: 2 isoforms:  Q9Y5K1-1   Q9Y5K1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SPO11: NX_Q9Y5K1

Explore proteomics data for SPO11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y5K1

  • SPO11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPO11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_036576.1  NP_937998.1  

    ENSEMBL proteins: 
     ENSP00000360310   ENSP00000316034   ENSP00000360307   ENSP00000413185   ENSP00000431842  
    Reactome Protein details: Q9Y5K1
    Human Recombinant Protein Products for SPO11: 
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    Novus Biologicals SPO11 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPO11 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IEA--
    GO:0005634nucleus IEA--
    GO:0005694chromosome ----

    SPO11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR011991 WHTH_DNA-bd_dom
     IPR013049 Spo11/TopoVI_A_N
     IPR013048 Meiotic_Spo11
     IPR004084 Meiosis_Spo11
     IPR002815 Spo11/TopoVI_A

    Graphical View of Domain Structure for InterPro Entry Q9Y5K1

    ProtoNet protein and cluster: Q9Y5K1

    2 Blocks protein domains:
    IPB013048 SPO11 homologue signature
    IPB013049 DNA topoisomerase


    UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1
    Similarity: Belongs to the TOP6A family


    SPO11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPO11_HUMAN, Q9Y5K1
    Function: Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that
    initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2
    (By similarity)

         Genatlas biochemistry entry for SPO11:
    Yeast meiosis specific gene homolog,required for double strand break formation required for initiation of
    recombination in S cerevisiae,expressed in prostate,testis,? and other tissues with an alternatively spliced
    isoform.

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003824catalytic activity ----
    GO:0005524ATP binding IEA--
    GO:0016787hydrolase activity IEA--
         
    SPO11 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Spo11):
     endocrine/exocrine gland  immune system  reproductive system 

    SPO11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SPO11: Spo11tm1Mjn Spo11tm1Rdco

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPO11 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPO11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPO11 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SPO11:
    hsa-miR-374b hsa-miR-3143 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidSPO11 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPO11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPO11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Meiotic Synapsis
    Meiosis0.70
    Meiotic Recombination0.62
    2Meiosis
    Meiosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SPO11
        Meiosis


    2        Reactome Pathways for SPO11
        Meiosis
    Meiotic Recombination



    SPO11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPO11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/24 Interacting proteins for SPO11 (Q9Y5K13 ENSP000003603104) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SSU72Q9NP773I2D: score=2 
    DEAF1O753983I2D: score=1 
    POLR2CP193873I2D: score=1 
    RBL1P287493I2D: score=1 
    RPS3P233963I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006259DNA metabolic process ----
    GO:0007129synapsis IEA--
    GO:0007131reciprocal meiotic recombination IEA--
    GO:0007141male meiosis I IEA--

    SPO11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPO11

    Search CenterWatch for drugs/clinical trials and news about SPO11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPO11 gene (2 alternative transcripts): 
    NM_012444.2  NM_198265.1  

    Unigene Cluster for SPO11:

    SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
    Hs.159737  [show with all ESTs]
    Unigene Representative Sequence: AF169385
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371263(uc002xye.3 uc002xyf.3) ENST00000345868 ENST00000371260
    ENST00000418127 ENST00000494972
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPO11
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate SPO11:
    hsa-miR-374b hsa-miR-3143 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidSPO11 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of SPO11 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPO11

    Additional mRNA sequence: 

    AF149310.1 AF169385.1 BC033591.1 

    2 DOTS entries:

    DT.101980571  DT.100748264 

    11 AceView cDNA sequences:

    BC033591 BX091792 NM_012444 NM_198265 BG183224 AF169385 AF149310 BI826715 
    BG188132 BI827785 AI393442 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SPO11    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                        -           -                                             
    SP2:              -                                         -           -                                             
    SP3:                                                                                -     -                           
    SP4:                                                              -     -                                             


    ECgene alternative splicing isoforms for SPO11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPO11 expression in normal human tissues (normalized intensities)      SPO11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTTGAC
    SPO11 Expression
    About this image


    SPO11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gonad
             Primary Oocyte Primordial Follicle
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primordial Follicle
     
     Testis (Reproductive System)
             Primary Spermatocyte Seminiferous Tubules

     -- (Integumentary System)
             skin   

    See SPO11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPO11

    SOURCE GeneReport for Unigene cluster: Hs.159737

    UniProtKB/Swiss-Prot: SPO11_HUMAN, Q9Y5K1
    Tissue specificity: Highly expressed in testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPO11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPO11 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spo111 , 5 sporulation protein, meiosis-specific, SPO11 homolog more5
    SPO11 meiotic protein covalently bound to DSB homolog more1
    81.9(n)1
    82.58(a)1
      2 (95.64 cM)5
    269721  NM_012046.21  NP_036176.11 
     1729777005 
    chicken
    (Gallus gallus)
    Aves SPO111 SPO11 meiotic protein covalently bound to DSB homolog more 75.45(n)
    73.37(a)
      768915  XM_001232075.2  XP_001232076.2 
    zebrafish
    (Danio rerio)
    Actinopterygii spo111 SPO11 meiotic protein covalently bound to DSB homolog more 59.98(n)
    60.16(a)
      402982  NM_205682.1  NP_991245.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mei-W681 , 3 meiotic recombination DNA topoisomerase
    (ATP-hydrolyzing)3
    meiotic W681
    35(a)3
    46.01(n)1
    36.27(a)1
      23
    27688531  NM_206179.11  NP_995901.11 
    worm
    (Caenorhabditis elegans)
    Secernentea spo-113   -- 32(a)   IV(11123334-11124910)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPO11(YHL022C)4 Meiosis-specific protein that initiates meiotic recombination more   --   8(64157-62961) 856364  NP_011841.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RHL21 DNA topoisomerase 6 subunit A 48.38(n)
    37.71(a)
      831314  NM_120360.3  NP_195902.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02848001 hypothetical protein 44.32(n)
    36.68(a)
      4332470  NM_001056300.1  NP_001049765.2 


    ENSEMBL Gene Tree for SPO11 (if available)
    TreeFam Gene Tree for SPO11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/372 SNPs in SPO11 are shown (see all 372)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75094231,2
    C--55902866(+) ggagaC/Ttgcag 2 -- us2k1 tfbs30--------
    rs58421671,2
    C--55902930(+) ATCTC-/A/AA  
            
    AAAAA
    2 -- us2k1 trp33NA CSA 6
    rs1169793061,2
    C,F--55902987(+) GGCTCC/TGAGCT 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1513031061,2
    --55903167(+) GTGAAA/CAGAGG 2 -- us2k10--------
    rs1931973351,2
    --55903171(+) ACAGAG/TGGAGT 2 -- us2k10--------
    rs1162594001,2
    F--55903234(+) GGAACG/AGAAAG 2 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1405729121,2
    --55903497(+) GAGGAA/GCTACA 2 -- us2k10--------
    rs1851691211,2
    --55903636(+) AGCAAC/TTCCTG 2 -- us2k10--------
    rs1907553521,2
    --55903702(+) AAATCA/TGGTAC 2 -- us2k10--------
    rs283680591,2
    C,F--55903708(+) GGTACA/GACTCC 2 -- us2k16Minor allele frequency- G:0.01NS EA 288

    HapMap Linkage Disequilibrium report for SPO11 (55904815 - 55919050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SPO11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv459027CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605114    OMIM disorders: --

    6 diseases for SPO11:    About MalaCards
    premature ovarian failure    male infertility    azoospermia    infertility
    melanoma    prostatitis


    SPO11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPO11
    Human Genome Epidemiology (HuGE) Navigator: SPO11 (4 documents)

    Export disorders for SPO11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPO11 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with SPO11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, characterization, and localization of mouse and human SPO11. (PubMed id 10534401)1, 2, 3 Romanienko P.J. and Camerini-Otero R.D. (1999)
    2. Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis. (PubMed id 10622720)1, 2, 9 Shannon M.... Thelen M.P. (1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Evaluation of 172 candidate polymorphisms for associa tion with oligozoospermia or azoospermia in a large cohort of men of European d escent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (2010)
    5. Genetic investigation of four meiotic genes in women with premature ovarian failure. (PubMed id 18166824)1, 4 Mandon-Pepin B....Fellous M. (2008)
    6. Screening the SPO11 and EIF5A2 genes in a population of infertile men. (PubMed id 16169419)1, 4 Christensen G.L....Carrell D.T. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    9. An association study of SPO11 gene single nucleotide p olymorphisms with idiopathic male infertility in Chinese Han population. (PubMed id 21556891)1 Zhang J....Tian Z. (2011)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23626 HGNC: 11250 AceView: SPO11 Ensembl:ENSG00000054796 euGenes: HUgn23626
    ECgene: SPO11 H-InvDB: SPO11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPO11 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/spo11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPO11 gene:
    Search GeneIP for patents involving SPO11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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