Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPO11 Gene

Aliases for SPO11 Gene

  • SPO11, Initiator Of Meiotic Double Stranded Breaks 2
  • SPO11 Meiotic Protein Covalently Bound To DSB 2 3 5
  • Cancer/Testis Antigen 35 2 3 4
  • Spermatogenesis Associated 43 2 3
  • CT35 3 4
  • SPO11 Meiotic Protein Covalently Bound To DSB Homolog (S. Cerevisiae) 2
  • SPO11, Meiotic Protein Covalently Bound To DSB (S. Cerevisiae)-Like 2
  • SPO11 Meiotic Protein Covalently Bound To DSB-Like (S. Cerevisiae) 2
  • SPO11 Meiotic Protein Covalently Bound To DSB Homolog 3
  • SPATA43 3
  • TOPVIA 3

External Ids for SPO11 Gene

Previous GeneCards Identifiers for SPO11 Gene

  • GC20P055633
  • GC20P056543
  • GC20P056590
  • GC20P055338
  • GC20P055905
  • GC20P052686

Summaries for SPO11 Gene

Entrez Gene Summary for SPO11 Gene

  • Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for SPO11 Gene

SPO11 (SPO11, Initiator Of Meiotic Double Stranded Breaks) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Meiosis. GO annotations related to this gene include hydrolase activity.

UniProtKB/Swiss-Prot for SPO11 Gene

  • Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPO11 Gene

Genomics for SPO11 Gene

Regulatory Elements for SPO11 Gene

Genomic Location for SPO11 Gene

Chromosome:
20
Start:
57,329,759 bp from pter
End:
57,343,994 bp from pter
Size:
14,236 bases
Orientation:
Plus strand

Genomic View for SPO11 Gene

Genes around SPO11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPO11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPO11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPO11 Gene

Proteins for SPO11 Gene

  • Protein details for SPO11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5K1-SPO11_HUMAN
    Recommended name:
    Meiotic recombination protein SPO11
    Protein Accession:
    Q9Y5K1
    Secondary Accessions:
    • Q5TCI1
    • Q8N4V0
    • Q9NQM7
    • Q9NQM8

    Protein attributes for SPO11 Gene

    Size:
    396 amino acids
    Molecular mass:
    44537 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPO11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPO11 Gene

Proteomics data for SPO11 Gene at MOPED

Post-translational modifications for SPO11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPO11 Gene

Antibody Products

No data available for DME Specific Peptides for SPO11 Gene

Domains & Families for SPO11 Gene

Suggested Antigen Peptide Sequences for SPO11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5K1

UniProtKB/Swiss-Prot:

SPO11_HUMAN :
  • Belongs to the TOP6A family.
Family:
  • Belongs to the TOP6A family.
genes like me logo Genes that share domains with SPO11: view

No data available for Gene Families for SPO11 Gene

Function for SPO11 Gene

Molecular function for SPO11 Gene

GENATLAS Biochemistry:
Yeast meiosis specific gene homolog,required for double strand break formation required for initiation of recombination in S cerevisiae,expressed in prostate,testis,? and other tissues with an alternatively spliced isoform.
UniProtKB/Swiss-Prot Function:
Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2 (By similarity).

Gene Ontology (GO) - Molecular Function for SPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 26917763
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with SPO11: view
genes like me logo Genes that share phenotypes with SPO11: view

Animal Models for SPO11 Gene

MGI Knock Outs for SPO11:

Animal Model Products

miRNA for SPO11 Gene

miRTarBase miRNAs that target SPO11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPO11 Gene

Localization for SPO11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPO11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPO11 Gene COMPARTMENTS Subcellular localization image for SPO11 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with SPO11: view

Pathways & Interactions for SPO11 Gene

SuperPathways for SPO11 Gene

Superpath Contained pathways
1 Meiosis
.73
2 Cell Cycle, Mitotic
genes like me logo Genes that share pathways with SPO11: view

Pathways by source for SPO11 Gene

3 Reactome pathways for SPO11 Gene

Interacting Proteins for SPO11 Gene

Gene Ontology (GO) - Biological Process for SPO11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0006259 DNA metabolic process IEA --
GO:0007129 synapsis IEA --
GO:0007130 synaptonemal complex assembly IEA --
GO:0007131 reciprocal meiotic recombination IEA --
genes like me logo Genes that share ontologies with SPO11: view

No data available for SIGNOR curated interactions for SPO11 Gene

Drugs & Compounds for SPO11 Gene

No Compound Related Data Available

Transcripts for SPO11 Gene

mRNA/cDNA for SPO11 Gene

Unigene Clusters for SPO11 Gene

SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPO11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
SP1: - -
SP2: - - -
SP3: - -
SP4: - -

Relevant External Links for SPO11 Gene

GeneLoc Exon Structure for
SPO11
ECgene alternative splicing isoforms for
SPO11

Expression for SPO11 Gene

mRNA expression in normal human tissues for SPO11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPO11 Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for SPO11 Gene

This gene is overexpressed in Plasma (48.5) and Cerebrospinal fluid (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPO11 Gene



SOURCE GeneReport for Unigene cluster for SPO11 Gene Hs.159737

mRNA Expression by UniProt/SwissProt for SPO11 Gene

Q9Y5K1-SPO11_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with SPO11: view

Protein tissue co-expression partners for SPO11 Gene

Primer Products

In Situ Assay Products

Orthologs for SPO11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPO11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPO11 35
  • 89.45 (n)
  • 90.38 (a)
SPO11 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPO11 35
  • 90.57 (n)
  • 90.4 (a)
SPO11 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spo11 35
  • 81.9 (n)
  • 82.58 (a)
Spo11 16
Spo11 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPO11 35
  • 99.41 (n)
  • 98.99 (a)
SPO11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spo11 35
  • 81.22 (n)
  • 83.54 (a)
oppossum
(Monodelphis domestica)
Mammalia SPO11 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPO11 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPO11 35
  • 75.45 (n)
  • 73.37 (a)
zebrafish
(Danio rerio)
Actinopterygii spo11 35
  • 59.98 (n)
  • 60.16 (a)
spo11 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mei-W68 37
  • 35 (a)
mei-W68 35
  • 46.08 (n)
  • 36.49 (a)
mei-W68 36
  • 34 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010898 35
  • 46.03 (n)
  • 38.1 (a)
worm
(Caenorhabditis elegans)
Secernentea spo-11 37
  • 32 (a)
spo-11 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPO11 38
thale cress
(Arabidopsis thaliana)
eudicotyledons RHL2 35
  • 48.38 (n)
  • 37.71 (a)
rice
(Oryza sativa)
Liliopsida Os03g0284800 35
  • 44.32 (n)
  • 36.68 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for SPO11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPO11 Gene

ENSEMBL:
Gene Tree for SPO11 (if available)
TreeFam:
Gene Tree for SPO11 (if available)

Paralogs for SPO11 Gene

No data available for Paralogs for SPO11 Gene

Variants for SPO11 Gene

Sequence variations from dbSNP and Humsavar for SPO11 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_023307 -
VAR_029246 -
VAR_052596 -
VAR_052597 -

Structural Variations from Database of Genomic Variants (DGV) for SPO11 Gene

Variant ID Type Subtype PubMed ID
nsv459027 CNV Loss 19166990

Variation tolerance for SPO11 Gene

Residual Variation Intolerance Score: 62.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPO11 Gene

HapMap Linkage Disequilibrium report
SPO11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPO11 Gene

Disorders for SPO11 Gene

Relevant External Links for SPO11

Genetic Association Database (GAD)
SPO11
Human Genome Epidemiology (HuGE) Navigator
SPO11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPO11

No disorders were found for SPO11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPO11 Gene

Publications for SPO11 Gene

  1. Cloning, characterization, and localization of mouse and human SPO11. (PMID: 10534401) Romanienko P.J. … Camerini-Otero R.D. (Genomics 1999) 2 3 4 67
  2. Differential gene expression of mammalian SPO11/TOP6A homologs during meiosis. (PMID: 10622720) Shannon M. … Thelen M.P. (FEBS Lett. 1999) 3 23
  3. Study of single nucleotide polymorphism (rs28368082) in SPO11 gene and its association with male infertility. (PMID: 25005169) Ghalkhani E. … Malekasgar A.M. (J. Assist. Reprod. Genet. 2014) 3
  4. An association study of SPO11 gene single nucleotide polymorphisms with idiopathic male infertility in Chinese Han population. (PMID: 21556891) Zhang J. … Tian Z. (J. Assist. Reprod. Genet. 2011) 3
  5. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PMID: 20378615) Aston K.I. … Carrell D.T. (Hum. Reprod. 2010) 3

Products for SPO11 Gene

Sources for SPO11 Gene

Back to Top

Content