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Aliases for SPNS3 Gene

Aliases for SPNS3 Gene

  • Spinster Homolog 3 (Drosophila) 2 3 5

External Ids for SPNS3 Gene

Previous GeneCards Identifiers for SPNS3 Gene

  • GC17P004284

Summaries for SPNS3 Gene

GeneCards Summary for SPNS3 Gene

SPNS3 (Spinster Homolog 3 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity and sphingolipid transporter activity. An important paralog of this gene is SPNS1.

UniProtKB/Swiss-Prot for SPNS3 Gene

  • Sphingolipid transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPNS3 Gene

Genomics for SPNS3 Gene

Regulatory Elements for SPNS3 Gene

Enhancers for SPNS3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPNS3 on UCSC Golden Path with GeneCards custom track

Promoters for SPNS3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPNS3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPNS3 Gene

4,433,688 bp from pter
4,488,208 bp from pter
54,521 bases
Plus strand

Genomic View for SPNS3 Gene

Genes around SPNS3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPNS3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPNS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPNS3 Gene

Proteins for SPNS3 Gene

  • Protein details for SPNS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein spinster homolog 3
    Protein Accession:
    Secondary Accessions:
    • Q8IZ31

    Protein attributes for SPNS3 Gene

    512 amino acids
    Molecular mass:
    54769 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPNS3 Gene


neXtProt entry for SPNS3 Gene

Proteomics data for SPNS3 Gene at MOPED

Post-translational modifications for SPNS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPNS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPNS3 Gene

Domains & Families for SPNS3 Gene

Protein Domains for SPNS3 Gene


Suggested Antigen Peptide Sequences for SPNS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
genes like me logo Genes that share domains with SPNS3: view

No data available for Gene Families for SPNS3 Gene

Function for SPNS3 Gene

Molecular function for SPNS3 Gene

UniProtKB/Swiss-Prot Function:
Sphingolipid transporter.
genes like me logo Genes that share phenotypes with SPNS3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SPNS3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SPNS3 Gene

Localization for SPNS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPNS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SPNS3 Gene COMPARTMENTS Subcellular localization image for SPNS3 gene
Compartment Confidence
lysosome 3
plasma membrane 3
vacuole 3

No data available for Gene Ontology (GO) - Cellular Components for SPNS3 Gene

Pathways & Interactions for SPNS3 Gene

SuperPathways for SPNS3 Gene

No Data Available

Interacting Proteins for SPNS3 Gene

Gene Ontology (GO) - Biological Process for SPNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SPNS3: view

No data available for Pathways by source and SIGNOR curated interactions for SPNS3 Gene

Drugs & Compounds for SPNS3 Gene

No Compound Related Data Available

Transcripts for SPNS3 Gene

Unigene Clusters for SPNS3 Gene

Spinster homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPNS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -

Relevant External Links for SPNS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPNS3 Gene

mRNA expression in normal human tissues for SPNS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPNS3 Gene

This gene is overexpressed in Whole Blood (x10.0) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for SPNS3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPNS3 Gene

SOURCE GeneReport for Unigene cluster for SPNS3 Gene Hs.657543

genes like me logo Genes that share expression patterns with SPNS3: view

Protein tissue co-expression partners for SPNS3 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SPNS3 Gene

Orthologs for SPNS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPNS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPNS3 35
  • 85.03 (n)
  • 83.43 (a)
SPNS3 36
  • 76 (a)
(Canis familiaris)
Mammalia SPNS3 35
  • 83.09 (n)
  • 80.87 (a)
SPNS3 36
  • 75 (a)
(Mus musculus)
Mammalia Spns3 35
  • 81.49 (n)
  • 80.43 (a)
Spns3 16
Spns3 36
  • 78 (a)
(Pan troglodytes)
Mammalia SPNS3 35
  • 97.53 (n)
  • 97.03 (a)
SPNS3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Spns3 35
  • 81.2 (n)
  • 80.37 (a)
(Ornithorhynchus anatinus)
Mammalia SPNS3 36
  • 58 (a)
(Gallus gallus)
Aves SPNS3 35
  • 59.03 (n)
  • 53.75 (a)
SPNS3 36
  • 51 (a)
(Anolis carolinensis)
Reptilia SPNS3 36
  • 56 (a)
(Danio rerio)
Actinopterygii spns3 35
  • 57.16 (n)
  • 54.39 (a)
spns3 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta spin 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea spin-1 36
  • 33 (a)
spin-2 36
  • 33 (a)
spin-3 36
  • 31 (a)
spin-4 36
  • 32 (a)
(Oryza sativa)
Liliopsida Os04g0525900 35
  • 40.61 (n)
  • 29.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5353 36
  • 29 (a)
Species with no ortholog for SPNS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPNS3 Gene

Gene Tree for SPNS3 (if available)
Gene Tree for SPNS3 (if available)

Paralogs for SPNS3 Gene

Paralogs for SPNS3 Gene

(3) SIMAP similar genes for SPNS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPNS3: view

Variants for SPNS3 Gene

Sequence variations from dbSNP and Humsavar for SPNS3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34457931 - 4,449,341(-) CAGCC(C/T)GTGAA intron-variant, nc-transcript-variant, reference, missense
rs11655342 - 4,453,080(+) AAGCT(G/T)CGAGG nc-transcript-variant, reference, missense
VAR_035968 A colorectal cancer sample
rs86946 -- 4,478,965(-) AACTC(C/T)GTCTC intron-variant
rs167986 -- 4,475,889(-) CAGTG(C/T)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPNS3 Gene

Variant ID Type Subtype PubMed ID
dgv3046n71 CNV Gain 21882294
nsv833345 CNV Loss 17160897
dgv3047n71 CNV Gain 21882294
dgv3048n71 CNV Gain 21882294
nsv907600 CNV Loss 21882294
nsv457650 CNV Gain 19166990
nsv907604 CNV Gain+Loss 21882294
nsv907605 CNV Loss 21882294
nsv907606 CNV Gain 21882294
esv1095840 CNV Deletion 17803354
esv2715553 CNV Deletion 23290073
nsv907607 CNV Gain 21882294
esv2148441 CNV Deletion 18987734
esv2715554 CNV Deletion 23290073
esv2659289 CNV Deletion 23128226
nsv513461 CNV Insertion 21212237
nsv907608 CNV Gain 21882294
dgv3049n71 CNV Loss 21882294

Variation tolerance for SPNS3 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPNS3 Gene

Disorders for SPNS3 Gene

Relevant External Links for SPNS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPNS3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPNS3 Gene

Publications for SPNS3 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SPNS3 Gene

Sources for SPNS3 Gene