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Aliases for SPNS3 Gene

Aliases for SPNS3 Gene

  • Spinster Homolog 3 (Drosophila) 2 3

External Ids for SPNS3 Gene

Previous GeneCards Identifiers for SPNS3 Gene

  • GC17P004284

Summaries for SPNS3 Gene

GeneCards Summary for SPNS3 Gene

SPNS3 (Spinster Homolog 3 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is SPNS1.

UniProtKB/Swiss-Prot for SPNS3 Gene

  • Sphingolipid transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPNS3 Gene

Genomics for SPNS3 Gene

Regulatory Elements for SPNS3 Gene

Genomic Location for SPNS3 Gene

4,433,688 bp from pter
4,488,208 bp from pter
54,521 bases
Plus strand

Genomic View for SPNS3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPNS3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPNS3 Gene

Proteins for SPNS3 Gene

  • Protein details for SPNS3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein spinster homolog 3
    Protein Accession:
    Secondary Accessions:
    • Q8IZ31

    Protein attributes for SPNS3 Gene

    512 amino acids
    Molecular mass:
    54769 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SPNS3 Gene


neXtProt entry for SPNS3 Gene

Proteomics data for SPNS3 Gene at MOPED

Post-translational modifications for SPNS3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPNS3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPNS3 Gene

Domains for SPNS3 Gene

Protein Domains for SPNS3 Gene


Suggested Antigen Peptide Sequences for SPNS3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZMD2
  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
genes like me logo Genes that share domains with SPNS3: view

No data available for Gene Families for SPNS3 Gene

Function for SPNS3 Gene

Molecular function for SPNS3 Gene

UniProtKB/Swiss-Prot Function:
Sphingolipid transporter.

Gene Ontology (GO) - Molecular Function for SPNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity --
GO:0046624 sphingolipid transporter activity IBA --
genes like me logo Genes that share ontologies with SPNS3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPNS3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPNS3 Gene

Localization for SPNS3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPNS3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SPNS3 Gene COMPARTMENTS Subcellular localization image for SPNS3 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SPNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0031982 vesicle IBA --
genes like me logo Genes that share ontologies with SPNS3: view

Pathways for SPNS3 Gene

SuperPathways for SPNS3 Gene

No Data Available

Interacting Proteins for SPNS3 Gene

Gene Ontology (GO) - Biological Process for SPNS3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IBA --
GO:0006869 lipid transport IEA --
GO:0040011 locomotion IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SPNS3: view

No data available for Pathways by source for SPNS3 Gene

Transcripts for SPNS3 Gene

Unigene Clusters for SPNS3 Gene

Spinster homolog 3 (Drosophila):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPNS3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPNS3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2: - -

Relevant External Links for SPNS3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPNS3 Gene

mRNA expression in normal human tissues for SPNS3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPNS3 Gene

This gene is overexpressed in Whole Blood (10.0) and Spleen (4.3).

Protein differential expression in normal tissues for SPNS3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPNS3 Gene

SOURCE GeneReport for Unigene cluster for SPNS3 Gene Hs.657543

genes like me logo Genes that share expressions with SPNS3: view

Expression partners for SPNS3 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SPNS3 Gene

Orthologs for SPNS3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPNS3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPNS3 35
  • 85.03 (n)
  • 83.43 (a)
SPNS3 36
  • 76 (a)
(Canis familiaris)
Mammalia SPNS3 35
  • 83.09 (n)
  • 80.87 (a)
SPNS3 36
  • 75 (a)
(Mus musculus)
Mammalia Spns3 35
  • 81.49 (n)
  • 80.43 (a)
Spns3 16
Spns3 36
  • 78 (a)
(Pan troglodytes)
Mammalia SPNS3 35
  • 97.53 (n)
  • 97.03 (a)
SPNS3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Spns3 35
  • 81.2 (n)
  • 80.37 (a)
(Ornithorhynchus anatinus)
Mammalia SPNS3 36
  • 58 (a)
(Gallus gallus)
Aves SPNS3 35
  • 59.03 (n)
  • 53.75 (a)
SPNS3 36
  • 51 (a)
(Anolis carolinensis)
Reptilia SPNS3 36
  • 56 (a)
(Danio rerio)
Actinopterygii spns3 35
  • 57.16 (n)
  • 54.39 (a)
spns3 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta spin 36
  • 31 (a)
(Caenorhabditis elegans)
Secernentea spin-1 36
  • 33 (a)
spin-2 36
  • 33 (a)
spin-3 36
  • 31 (a)
spin-4 36
  • 32 (a)
(Oryza sativa)
Liliopsida Os04g0525900 35
  • 40.61 (n)
  • 29.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5353 36
  • 29 (a)
Species with no ortholog for SPNS3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPNS3 Gene

Gene Tree for SPNS3 (if available)
Gene Tree for SPNS3 (if available)

Paralogs for SPNS3 Gene

Paralogs for SPNS3 Gene

Selected SIMAP similar genes for SPNS3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPNS3: view

Variants for SPNS3 Gene

Sequence variations from dbSNP and Humsavar for SPNS3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs86946 -- 4,478,965(-) AACTC(C/T)GTCTC intron-variant
rs167986 -- 4,475,889(-) CAGTG(C/T)ATGCT intron-variant
rs170775 -- 4,483,205(-) CAAGT(C/T)GGAGC intron-variant
rs184567 -- 4,482,100(-) gacca(G/T)cctgg intron-variant
rs184568 -- 4,482,078(-) aaccc(C/T)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPNS3 Gene

Variant ID Type Subtype PubMed ID
dgv3046n71 CNV Gain 21882294
nsv833345 CNV Loss 17160897
dgv3047n71 CNV Gain 21882294
dgv3048n71 CNV Gain 21882294
nsv907600 CNV Loss 21882294
nsv457650 CNV Gain 19166990
nsv907604 CNV Gain+Loss 21882294
nsv907605 CNV Loss 21882294
nsv907606 CNV Gain 21882294
esv1095840 CNV Deletion 17803354
esv2715553 CNV Deletion 23290073
nsv907607 CNV Gain 21882294
esv2148441 CNV Deletion 18987734
esv2715554 CNV Deletion 23290073
esv2659289 CNV Deletion 23128226
nsv513461 CNV Insertion 21212237
nsv907608 CNV Gain 21882294
dgv3049n71 CNV Loss 21882294

Relevant External Links for SPNS3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPNS3 Gene

Disorders for SPNS3 Gene

Relevant External Links for SPNS3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SPNS3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SPNS3 Gene

Publications for SPNS3 Gene

  1. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PMID: 17714910) Jacobsson J.A. … Fredriksson R. (Genomics 2007) 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SPNS3 Gene

Sources for SPNS3 Gene

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