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SPNS3 Gene

protein-coding   GIFtS: 47
GCID: GC17P004284

Spinster Homolog 3 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spinster Homolog 3 (Drosophila)1 2
Protein Spinster Homolog 32

External Ids:    HGNC: 284331   Entrez Gene: 2013052   Ensembl: ENSG000001825577   OMIM: 6117015   UniProtKB: Q6ZMD23   

Export aliases for SPNS3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPNS3 Gene:
SPNS3 (spinster homolog 3 (Drosophila)) is a protein-coding gene. Diseases associated with SPNS3 include breast and colorectal cancer, and obesity. An important paralog of this gene is SPNS2.

UniProtKB/Swiss-Prot: SPNS3_HUMAN, Q6ZMD2
Function: Sphingolipid transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPNS3 gene promoter:
         Elk-1   C/EBPbeta   NF-1   USF1   AML1a   Lmo2   c-Ets-1   Arnt   USF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPNS3 promoter sequence
   Search Chromatin IP Primers for SPNS3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPNS3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

SPNS3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPNS3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004284:  view genomic region     (about GC identifiers)

Start:
4,336,983 bp from pter      End:
4,391,503 bp from pter
Size:
54,521 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPNS3_HUMAN, Q6ZMD2 (See protein sequence)
Recommended Name: Protein spinster homolog 3  
Size: 512 amino acids; 54769 Da
Secondary accessions: Q8IZ31
Alternative splicing: 2 isoforms:  Q6ZMD2-1   Q6ZMD2-2   

Explore the universe of human proteins at neXtProt for SPNS3: NX_Q6ZMD2

Explore proteomics data for SPNS3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPNS3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_872344.3  
    ENSEMBL proteins: 
     ENSP00000347721   ENSP00000460781   ENSP00000333207  

    SPNS3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Cloud-Clone Corp. Proteins for SPNS3

    SPNS3 Antibody Products:

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    Novus Biologicals SPNS3 Antibodies
    Abcam antibodies for SPNS3
    Cloud-Clone Corp. Antibodies for SPNS3
    Search ThermoFisher Antibodies for SPNS3
    Search LSBio for Antibodies for SPNS3

    SPNS3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPNS3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPNS3
    Cloud-Clone Corp. CLIAs for SPNS3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q6ZMD2

    ProtoNet protein and cluster: Q6ZMD2

    UniProtKB/Swiss-Prot: SPNS3_HUMAN, Q6ZMD2
    Similarity: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family


    SPNS3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPNS3_HUMAN, Q6ZMD2
    Function: Sphingolipid transporter (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
         
    SPNS3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPNS3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPNS3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPNS3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPNS3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SPNS3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SPNS3:
    hsa-miR-3660 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPNS3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPNS3
    Predesigned siRNA for gene silencing in human, mouse, rat SPNS3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPNS3

    Clone
    Products:
         
    OriGene clones in human, mouse for SPNS3 (see all 7)
    OriGene ORF clones in mouse, rat for SPNS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPNS3 (NM_182538)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPNS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPNS3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPNS3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPNS3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPNS3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPNS3_HUMAN, Q6ZMD2: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    SPNS3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPNS3
    Interactions:

        Search GeneGlobe Interaction Network for SPNS3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SPNS3 (ENSP000003477214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2ENSP000003637084STRING: ENSP00000363708
    BMPR1BENSP000002645684STRING: ENSP00000264568
    ACVR1ENSP000002636404STRING: ENSP00000263640
    --ENSP000002247644STRING: ENSP00000224764
    --ENSP000002670084STRING: ENSP00000267008
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006869lipid transport IEA--
    GO:0055085transmembrane transport IEA--

    SPNS3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPNS3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPNS3 gene: 
    NM_182538.4  

    Unigene Cluster for SPNS3:

    Spinster homolog 3 (Drosophila)
    Hs.657543  [show with all ESTs]
    Unigene Representative Sequence: NM_182538
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355530(uc002fxt.3 uc002fxu.3) ENST00000576069 ENST00000575194
    ENST00000572078 ENST00000575185 ENST00000575796 ENST00000333476
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPNS3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate SPNS3:
    hsa-miR-3660 hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidSPNS3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPNS3
    Predesigned siRNA for gene silencing in human, mouse, rat SPNS3
    Clone
    Products:
         
    OriGene clones in human, mouse for SPNS3 (see all 7)
    OriGene ORF clones in mouse, rat for SPNS3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPNS3 (NM_182538)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPNS3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPNS3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPNS3
    OriGene qSTAR qPCR primer pairs in human, mouse for SPNS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPNS3
      QuantiTect SYBR Green Assays in human, mouse, rat SPNS3
      QuantiFast Probe-based Assays in human, mouse, rat SPNS3

    Additional mRNA sequence: 

    AK172832.1 BC023646.2 

    5 DOTS entries:

    DT.100640736  DT.95366354  DT.100758198  DT.120925162  DT.97817630 

    Selected AceView cDNA sequences (see all 62):

    CR611034 CR624976 CR606228 CR618257 CR593280 CR614611 BX447675 BQ421101 
    BX427523 BX644698 AL581027 BX386585 AK172832 BQ051936 BM695341 BQ052645 
    BI262415 BX644771 BI762201 BX393119 AL561668 BX387089 NM_182538 AL559398 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SPNS3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                    -                                                                     
    SP2:                    -     -                                                               
    SP3:                                                                                          


    ECgene alternative splicing isoforms for SPNS3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPNS3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTTGGGC
    SPNS3 Expression
    About this image


    SPNS3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Lymph (Hematopoietic System)
    SPNS3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPNS3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.657543
        Custom PCR Arrays for SPNS3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPNS3
    OriGene qSTAR qPCR primer pairs in human, mouse for SPNS3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPNS3
    QuantiTect SYBR Green Assays in human, mouse, rat SPNS3
    QuantiFast Probe-based Assays in human, mouse, rat SPNS3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPNS3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPNS3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spns31 , 5 spinster homolog 3 (Drosophila)5
    spinster homolog 31
    81.49(n)1
    80.43(a)1
      11 (44.34 cM)5
    775771  NM_029932.31  NP_084208.11 
     724949195 
    chicken
    (Gallus gallus)
    Aves SPNS31 spinster homolog 3 (Drosophila) 59.03(n)
    53.75(a)
      417493  XM_004946447.1  XP_004946504.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPNS36
    spinster homolog 3 (Drosophila)
    56(a)
    1 ↔ 1
    GL344715.1(566-12212)
    zebrafish
    (Danio rerio)
    Actinopterygii spns31 spinster homolog 3 (Drosophila) 57.16(n)
    54.39(a)
      568387  NM_001100036.1  NP_001093506.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spin6
    spinster
    31(a)
    1 → many
    2R(12012488-12025743)
    worm
    (Caenorhabditis elegans)
    Secernentea spin-26
    spin-16
    (see all 4)
    Protein C13C4.5 (C13C4.5) mRNA, complete cds
    (see all 4)
    33(a)
    33(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    IV(13087005-13089618) WBGene00008033
    V(12114993-12117561) WBGene00007549
    rice
    (Oryza sativa)
    Liliopsida Os04g05259001 Os04g0525900 40.61(n)
    29.47(a)
      4336451  NM_001059895.1  NP_001053360.1 


    ENSEMBL Gene Tree for SPNS3 (if available)
    TreeFam Gene Tree for SPNS3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPNS3 gene
    SPNS22  SPNS12  
    3 SIMAP similar genes for SPNS3 using alignment to 2 protein entries:     SPNS3_HUMAN (see all proteins):
    SPNS1    SVOP    SPNS2

    SPNS3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPNS3 (see all 1708)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359684
    A colorectal cancer sample4--see VAR_0359682 A T mis40--------
    rs1417837531,2
    Cuntested14351524(+) GCTGCC/TGAGAC 2 A syn11Minor allele frequency- T:0.00NA 4202
    rs579684811,2
    C,F--4335224(+) TAACCA/TTAGTT 1 -- us2k13Minor allele frequency- T:0.06WA CSA 122
    rs739751191,2
    C--4335237(+) CAGATG/ACTGAT 1 -- us2k12Minor allele frequency- A:0.08WA 120
    rs1866481071,2
    --4335292(+) GGAGCA/GAGGTT 1 -- us2k10--------
    rs129513411,2
    H--4335330(+) TATTGT/GCTTGT 1 -- us2k14Minor allele frequency- G:0.00NS EA 408
    rs2006464371,2
    C--4335341(+) TCTCT-/C/TTTTTT 1 -- us2k10--------
    rs116577791,2
    C,F,A,H--4335389(+) ccaggT/Ctagag 1 -- us2k17Minor allele frequency- C:0.38NA WA CSA 13
    rs1925371551,2
    --4335438(+) CCCGGA/GTTCAC 1 -- us2k10--------
    rs1405331101,2
    --4335465(+) AGCCTA/CCTGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SPNS3 (4336983 - 4391503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPNS3 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1095840CNV Deletion17803354
    esv2659289CNV Deletion23128226
    esv2148441CNV Deletion18987734
    esv2715554CNV Deletion23290073
    esv2715553CNV Deletion23290073
    nsv513461CNV Insertion21212237
    nsv833345CNV Loss17160897
    nsv907600CNV Loss21882294
    dgv3049n71CNV Loss21882294
    nsv907605CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPNS3
    DNA2.0 Custom Variant and Variant Library Synthesis for SPNS3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611701    OMIM disorders: --

    3 diseases for SPNS3:    
    About MalaCards
    breast and colorectal cancer    obesity    colorectal cancer


    SPNS3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPNS3
    Human Genome Epidemiology (HuGE) Navigator: SPNS3 (1 document)

    Export disorders for SPNS3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPNS3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SPNS3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. (PubMed id 17714910)1, 2 Jacobsson J.A.... Fredriksson R. (Genomics 2007)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    4. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 201305 HGNC: 28433 AceView: MGC29671 Ensembl:ENSG00000182557 euGenes: HUgn201305
    ECgene: SPNS3 H-InvDB: SPNS3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPNS3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPNS3 gene:
    Search GeneIP for patents involving SPNS3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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