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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPNS2 Gene

protein-coding   GIFtS: 41
GCID: GC17P004349

Spinster Homolog 2 (Drosophila)

  Search for SPNS2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Spinster Homolog 2 (Drosophila)1 2
Protein Spinster Homolog 22

External Ids:    HGNC: 269921   Entrez Gene: 1249762   Ensembl: ENSG000001830187   OMIM: 6125845   UniProtKB: Q8IVW83   

Export aliases for SPNS2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPNS2 Gene: 
SPNS2 (spinster homolog 2 (Drosophila)) is a protein-coding gene. An important paralog of this gene is SPNS3.

UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8
Function: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine
1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and
neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer
(YSL), thereby regulating myocardial precursor migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPNS2 gene promoter:
         ER-alpha   RP58   Pax-5   GATA-1   AREB6   FAC1   ARP-1   c-Myb   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SPNS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPNS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

SPNS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPNS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004349:  view genomic region     (about GC identifiers)

Start:
4,402,129 bp from pter      End:
4,443,228 bp from pter
Size:
41,100 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8 (See protein sequence)
Recommended Name: Protein spinster homolog 2  
Size: 549 amino acids; 58044 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B9A1T3

Explore the universe of human proteins at neXtProt for SPNS2: NX_Q8IVW8

Explore proteomics data for SPNS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IVW8

  • SPNS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPNS2 Protein Expression
    REFSEQ proteins: NP_001118230.1  
    ENSEMBL proteins: 
     ENSP00000333292   ENSP00000461410  

    Human Recombinant Protein Products for SPNS2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPNS2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    SPNS2 for ontologies           About GeneDecksing



    SPNS2 Antibody Products: 
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    Assay Products for SPNS2: 
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    Cloud-Clone Corp. ELISAs for SPNS2 
    Cloud-Clone Corp. CLIAs for SPNS2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8IVW8

    ProtoNet protein and cluster: Q8IVW8

    UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8
    Similarity: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family


    SPNS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPNS2_HUMAN, Q8IVW8
    Function: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine
    1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and
    neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer
    (YSL), thereby regulating myocardial precursor migration

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
         
    SPNS2 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Spns2):
     behavior/neurological  cardiovascular system  cellular  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  pigmentation  skeleton  vision/eye 

    SPNS2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SPNS2: Spns2tm1b(KOMP)Wtsi Spns2tm1.2Nmoc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPNS2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPNS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPNS2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPNS2 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPNS2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SPNS2 (see all 31):
    hsa-miR-579 hsa-miR-485-5p hsa-miR-631 hsa-let-7a-2* hsa-miR-578 hsa-miR-181a-2* hsa-miR-650 hsa-miR-3661
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPNS2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPNS2

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis IEA--
    GO:0002920regulation of humoral immune response IEA--
    GO:0006869lipid transport IEA--
    GO:0043029T cell homeostasis IEA--
    GO:0048073regulation of eye pigmentation IEA--

    SPNS2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPNS2

    Search CenterWatch for drugs/clinical trials and news about SPNS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPNS2 gene: 
    NM_001124758.1  

    Unigene Cluster for SPNS2:

    Spinster homolog 2 (Drosophila)
    Hs.22824  [show with all ESTs]
    Unigene Representative Sequence: NM_001124758
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329078(uc002fxx.2) ENST00000571386 ENST00000576635 ENST00000571668
    ENST00000573106 ENST00000573990 ENST00000570641 ENST00000570979(uc002fxy.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPNS2
    8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SPNS2 (see all 31):
    hsa-miR-579 hsa-miR-485-5p hsa-miR-631 hsa-let-7a-2* hsa-miR-578 hsa-miR-181a-2* hsa-miR-650 hsa-miR-3661
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SPNS2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPNS2
    Clone
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    OriGene clones in human, mouse for SPNS2 (see all 5)
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    GenScript: all cDNA clones in your preferred vector: SPNS2 (NM_001124758)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPNS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPNS2
    Sirion Biotech Customized lentivirus for stable overexpression of SPNS2 
                         Customized lentivirus expression plasmids for stable overexpression of SPNS2 
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPNS2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPNS2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPNS2

    Additional mRNA sequence: 

    AB441165.1 BC041772.1 BC065221.1 

    16 DOTS entries:

    DT.100798032  DT.100798044  DT.40231828  DT.95367109  DT.100798034  DT.100728624  DT.100798037  DT.100798038 
    DT.455190  DT.95153081  DT.95293132  DT.100717857  DT.100798040  DT.121003724  DT.95373349  DT.97853605 

    24/116 AceView cDNA sequences (see all 116):

    AI268088 AI355796 AW450188 AI124640 AA535318 BM857149 AW028876 AI184425 
    BE042416 AW089043 AI560219 BM679233 AI913186 BX096396 CR602862 BG171161 
    BF111023 BX280500 AA515425 AW055312 BE047248 AI183511 CA426026 BM727337 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPNS2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                    -     -                 -     -     -                                       
    SP2:                    -     -                                                                     
    SP3:                    -     -                 -     -     -                                       
    SP4:                    -     -                             -                                       
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for SPNS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPNS2 expression in normal human tissues (normalized intensities)      SPNS2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACACCAG
    SPNS2 Expression
    About this image


    SPNS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             PureStem ES-335, Meso-latp Progenitor
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Human Brain Microvascular Endothelial Cells (HBMEC)   
             corpus callosum   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Human Renal Mesangial Cells (HRMC)   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
             PureStem endothelial progenitor 30-MV2-12
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Renal Epithelial Cells (HREpiC)   

    See SPNS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPNS2

    SOURCE GeneReport for Unigene cluster: Hs.22824
        SABiosciences Custom PCR Arrays for SPNS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPNS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPNS2 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spns21 , 5 spinster homolog 2 (Drosophila)5
    spinster homolog 21
    89.01(n)1
    95.99(a)1
      11 (44.31 cM)5
    2168921  NM_153060.21  NP_694700.21 
     724516385 
    chicken
    (Gallus gallus)
    Aves SPNS21 spinster homolog 2 (Drosophila) 78.59(n)
    92.89(a)
      417492  XM_415740.3  XP_415740.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.181392 Transcribed sequence with weak similarity to protein more 81.22(n)    AL959825.2 
    zebrafish
    (Danio rerio)
    Actinopterygii spns21 spinster homolog 2 (Drosophila) 68.74(n)
    73.35(a)
      568117  NM_001083847.1  NP_001077316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spin6
    spinster
    32(a)
    1 → many
    2R(12012488-12025743)
    worm
    (Caenorhabditis elegans)
    Secernentea C13C4.56
    Y111B2A.196
    (see all 4)
    Protein Y111B2A.19
    (see all 4)
    34(a)
    34(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    V(12114991-12117561)
    III(12688273-12697546)
    wheat
    (Triticum aestivum)
    Liliopsida Ta.283282 Triticum aestivum transcribed sequence with weak similarity more 70.02(n)    CD933306.1 


    ENSEMBL Gene Tree for SPNS2 (if available)
    TreeFam Gene Tree for SPNS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SPNS2 gene
    SPNS32  SPNS12  
    2 SIMAP similar genes for SPNS2 using alignment to 2 protein entries:     SPNS2_HUMAN (see all proteins):
    SPNS1    SPNS3

    SPNS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1173 SNPs in SPNS2 are shown (see all 1173)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156823251,2
    C,F--4400260(+) AAGAGA/CATGCT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs1415652931,2
    C--4400283(+) AAGGCC/TGAAAG 1 -- us2k10--------
    rs1126876271,2
    C,F--4400284(+) AGGCCG/AAAAGT 1 -- us2k12Minor allele frequency- A:0.06NA 122
    rs591652591,2
    C,F--4400304(+) GACAGG/CACTGT 1 -- us2k12Minor allele frequency- C:0.07WA 120
    rs116574641,2
    C,F,A,H--4400333(+) TTTTGA/GGGCAC 1 -- us2k112Minor allele frequency- G:0.23NA WA CSA EA 376
    rs1922283511,2
    --4400338(+) GGGCAC/TGGGAA 1 -- us2k10--------
    rs3331131,2
    C,F,A,H--4400356(+) CTGGGG/CTTGGG 1 -- us2k116Minor allele frequency- C:0.32NS EA NA WA CSA 853
    rs751750681,2
    C--4400372(+) AGTTGC/TGGTTG 1 -- us2k10--------
    rs80749651,2
    C,F--4400384(+) GCCTCC/ATTCAC 1 -- us2k17Minor allele frequency- A:0.44NA WA CSA 247
    rs116577851,2
    C,F,A,H--4400392(+) CACCAT/CTAGAC 1 -- us2k17Minor allele frequency- C:0.12NA 134

    HapMap Linkage Disequilibrium report for SPNS2 (4402129 - 4443228 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SPNS2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833345CNV Loss17160897
    nsv907605CNV Loss21882294
    dgv3051n71CNV Loss21882294
    dgv3050n71CNV Loss21882294
    dgv3049n71CNV Loss21882294
    esv1003136CNV Gain20482838

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SPNS2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPNS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SPNS2 for disorders           About MalaCards
    OMIM gene information: 612584    OMIM disorders: --


    SPNS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SPNS2

    Export disorders for SPNS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPNS2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SPNS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. (PubMed id 19074308)1, 2 Kawahara A....Mochizuki N. (2009)
    2. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. (PubMed id 12815463)1, 3 Yanagisawa H.... Yamamoto D. (2003)
    3. Spns2, a transporter of phosphorylated sphingoid bases , regulates their blood and lymph levels, and the lymphatic network. (PubMed id 23180825)1 Nagahashi M....Spiegel S. (2013)
    4. The sphingosine 1-phosphate transporter, SPNS2, funct ions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. (PubMed id 21084291)1 Hisano Y....Nishi T. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 124976 HGNC: 26992 AceView: LOC124976 Ensembl:ENSG00000183018 euGenes: HUgn124976
    ECgene: SPNS2 H-InvDB: SPNS2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPNS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPNS2 gene:
    Search GeneIP for patents involving SPNS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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