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SPNS2 Gene

protein-coding   GIFtS: 44
GCID: GC17P004402

Spinster Homolog 2 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spinster Homolog 2 (Drosophila)1 2
Protein Spinster Homolog 22

External Ids:    HGNC: 269921   Entrez Gene: 1249762   Ensembl: ENSG000001830187   OMIM: 6125845   UniProtKB: Q8IVW83   

Export aliases for SPNS2 gene to outside databases

Previous GC identifer: GC17P004349


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPNS2 Gene:
SPNS2 (spinster homolog 2 (Drosophila)) is a protein-coding gene. An important paralog of this gene is SPNS3.

UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8
Function: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine
1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and
neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer
(YSL), thereby regulating myocardial precursor migration




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPNS2 gene promoter:
         ER-alpha   RP58   Pax-5   GATA-1   AREB6   FAC1   ARP-1   c-Myb   Zic3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SPNS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPNS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2   Ensembl cytogenetic band:  17p13.2   HGNC cytogenetic band: 17p13.2

SPNS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPNS2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P004402:  view genomic region     (about GC identifiers)

Start:
4,402,129 bp from pter      End:
4,443,228 bp from pter
Size:
41,100 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8 (See protein sequence)
Recommended Name: Protein spinster homolog 2  
Size: 549 amino acids; 58044 Da
Secondary accessions: B9A1T3

Explore the universe of human proteins at neXtProt for SPNS2: NX_Q8IVW8

Explore proteomics data for SPNS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPNS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001118230.1  
    ENSEMBL proteins: 
     ENSP00000333292   ENSP00000461410  

    SPNS2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SPNS2

     
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    antibodies-online peptides for SPNS2

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    antibodies-online antibodies for SPNS2 (19 products) 

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    antibodies-online kits for SPNS2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR020846 MFS_dom
     IPR011701 MFS
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q8IVW8

    ProtoNet protein and cluster: Q8IVW8

    UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8
    Similarity: Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family


    Find genes that share domains with SPNS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPNS2_HUMAN, Q8IVW8
    Function: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine
    1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and
    neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer
    (YSL), thereby regulating myocardial precursor migration

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
    GO:0046624sphingolipid transporter activity IEA--
         
    Find genes that share ontologies with SPNS2           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Spns2):
     behavior/neurological  cardiovascular system  hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism 
     immune system  pigmentation  skeleton  vision/eye 

    Find genes that share phenotypes with SPNS2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SPNS2: Spns2tm1b(KOMP)Wtsi Spns2tm1.2Nmoc

       genOway: Develop your customized and physiologically relevant rodent model for SPNS2

    miRNA
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    miRTarBase miRNAs that target SPNS2:
    hsa-mir-335-5p (MIRT018966)

    Block miRNA regulation of human, mouse, rat SPNS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPNS2 (see all 31):
    hsa-miR-579 hsa-miR-485-5p hsa-miR-631 hsa-let-7a-2* hsa-miR-578 hsa-miR-181a-2* hsa-miR-650 hsa-miR-3661
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPNS2_HUMAN, Q8IVW8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SPNS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPNS2
    Interactions:

        Search GeneGlobe Interaction Network for SPNS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for SPNS2 (ENSP000003332924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2ENSP000003637084STRING: ENSP00000363708
    BMPR1BENSP000002645684STRING: ENSP00000264568
    ACVR1ENSP000002636404STRING: ENSP00000263640
    --ENSP000002247644STRING: ENSP00000224764
    --ENSP000002670084STRING: ENSP00000267008
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001782B cell homeostasis IEA--
    GO:0002260lymphocyte homeostasis ----
    GO:0002920regulation of humoral immune response IEA--
    GO:0003376sphingosine-1-phosphate signaling pathway IEA--
    GO:0006665sphingolipid metabolic process IEA--

    Find genes that share ontologies with SPNS2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPNS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SPNS2 gene: 
    NM_001124758.1  

    Unigene Cluster for SPNS2:

    Spinster homolog 2 (Drosophila)
    Hs.22824  [show with all ESTs]
    Unigene Representative Sequence: NM_001124758
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329078(uc002fxx.2) ENST00000571386 ENST00000576635 ENST00000571668
    ENST00000573106 ENST00000573990 ENST00000570641 ENST00000570979(uc002fxy.2)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SPNS2 (see all 31):
    hsa-miR-579 hsa-miR-485-5p hsa-miR-631 hsa-let-7a-2* hsa-miR-578 hsa-miR-181a-2* hsa-miR-650 hsa-miR-3661
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for SPNS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SPNS2
      QuantiTect SYBR Green Assays in human, mouse, rat SPNS2
      QuantiFast Probe-based Assays in human, mouse, rat SPNS2

    Additional mRNA sequence: 

    AB441165.1 BC041772.1 BC065221.1 

    16 DOTS entries:

    DT.100798032  DT.100798044  DT.40231828  DT.95367109  DT.100798034  DT.100728624  DT.100798037  DT.100798038 
    DT.455190  DT.95153081  DT.95293132  DT.100717857  DT.100798040  DT.121003724  DT.95373349  DT.97853605 

    Selected AceView cDNA sequences (see all 116):

    AI244723 AI183511 AI913186 CR602862 AW089043 BX096396 BM722582 CA426026 
    AA515425 BX280500 BE042416 AI124640 BG171161 BM670496 BM857149 AI560219 
    AI222569 AW450188 BM679233 BF111023 AW055312 AI268088 AW298213 AA535318 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SPNS2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
    SP1:                    -     -                 -     -     -                                       
    SP2:                    -     -                                                                     
    SP3:                    -     -                 -     -     -                                       
    SP4:                    -     -                             -                                       
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for SPNS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPNS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACACCAG
    SPNS2 Expression
    About this image


    SPNS2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    SPNS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPNS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22824
        Custom PCR Arrays for SPNS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPNS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SPNS2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spns21 , 5 spinster homolog 2 (Drosophila)5
    spinster homolog 21
    88.69(n)1
    96.77(a)1
      11 (44.31 cM)5
    2168921  NM_153060.31  NP_694700.21 
     724516385 
    chicken
    (Gallus gallus)
    Aves SPNS21 spinster homolog 2 (Drosophila) 79.54(n)
    94.31(a)
      417492  XM_004946444.1  XP_004946501.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.181392 Transcribed sequence with weak similarity to protein more 81.22(n)    AL959825.2 
    zebrafish
    (Danio rerio)
    Actinopterygii spns21 spinster homolog 2 (Drosophila) 69.9(n)
    74.79(a)
      568117  NM_001083847.1  NP_001077316.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spin6
    spinster
    32(a)
    1 → many
    2R(12012488-12025743)
    worm
    (Caenorhabditis elegans)
    Secernentea spin-16
    spin-46
    (see all 4)
    Protein C13C4.5 (C13C4.5) mRNA, complete cds
    Protein Y111B2A.19 (Y111B2A.19) mRNA, complete cds...
    (see all 4)
    35(a)
    35(a)
    (see all 4)
    many ↔ many
    many ↔ many
    (see all 4)
    V(12114993-12117561) WBGene00007549
    III(12688273-12697546) WBGene00013739
    wheat
    (Triticum aestivum)
    Liliopsida Ta.283282 Triticum aestivum transcribed sequence with weak similarity more 70.02(n)    CD933306.1 


    ENSEMBL Gene Tree for SPNS2 (if available)
    TreeFam Gene Tree for SPNS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPNS2 gene
    SPNS32  SPNS12  
    2 SIMAP similar genes for SPNS2 using alignment to 2 protein entries:     SPNS2_HUMAN (see all proteins):
    SPNS1    SPNS3

    Find genes that share paralogs with SPNS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPNS2 (see all 1173)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156823251,2
    C,F--4400260(+) AAGAGA/CATGCT 1 -- us2k11Minor allele frequency- C:0.07WA 118
    rs1415652931,2
    C--4400283(+) AAGGCC/TGAAAG 1 -- us2k10--------
    rs1126876271,2
    C,F--4400284(+) AGGCCG/AAAAGT 1 -- us2k12Minor allele frequency- A:0.06NA 122
    rs591652591,2
    C,F--4400304(+) GACAGG/CACTGT 1 -- us2k12Minor allele frequency- C:0.07WA 120
    rs116574641,2
    C,F,A,H--4400333(+) TTTTGA/GGGCAC 1 -- us2k112Minor allele frequency- G:0.23NA WA CSA EA 376
    rs1922283511,2
    --4400338(+) GGGCAC/TGGGAA 1 -- us2k10--------
    rs3331131,2
    C,F,A,H--4400356(+) CTGGGG/CTTGGG 1 -- us2k116Minor allele frequency- C:0.32NS EA NA WA CSA 853
    rs751750681,2
    C--4400372(+) AGTTGC/TGGTTG 1 -- us2k10--------
    rs80749651,2
    C,F--4400384(+) GCCTCC/ATTCAC 1 -- us2k17Minor allele frequency- A:0.44NA WA CSA 247
    rs116577851,2
    C,F,A,H--4400392(+) CACCAT/CTAGAC 1 -- us2k17Minor allele frequency- C:0.12NA 134

    HapMap Linkage Disequilibrium report for SPNS2 (4402129 - 4443228 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SPNS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833345CNV Loss17160897
    nsv907605CNV Loss21882294
    dgv3051n71CNV Loss21882294
    dgv3050n71CNV Loss21882294
    dgv3049n71CNV Loss21882294
    esv1003136CNV Gain20482838

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPNS2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPNS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612584    OMIM disorders: --


    Find genes that share disorders with SPNS2           About GenesLikeMe

    Genetic Association Database (GAD): SPNS2

    Export disorders for SPNS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPNS2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SPNS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. (PubMed id 19074308)1, 2 Kawahara A....Mochizuki N. (Science 2009)
    2. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. (PubMed id 12815463)1, 3 Yanagisawa H.... Yamamoto D. (Cell Death Differ. 2003)
    3. Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. (PubMed id 23180825)1 Nagahashi M....Spiegel S. (FASEB J. 2013)
    4. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. (PubMed id 21084291)1 Hisano Y....Nishi T. (J. Biol. Chem. 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 124976 HGNC: 26992 AceView: LOC124976 Ensembl:ENSG00000183018 euGenes: HUgn124976
    ECgene: SPNS2 H-InvDB: SPNS2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPNS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPNS2 gene:
    Search GeneIP for patents involving SPNS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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