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Aliases for SPNS2 Gene

Aliases for SPNS2 Gene

  • Spinster Homolog 2 (Drosophila) 2 3 5

External Ids for SPNS2 Gene

Previous GeneCards Identifiers for SPNS2 Gene

  • GC17P004349
  • GC17P004402

Summaries for SPNS2 Gene

GeneCards Summary for SPNS2 Gene

SPNS2 (Spinster Homolog 2 (Drosophila)) is a Protein Coding gene. GO annotations related to this gene include transmembrane transporter activity and sphingolipid transporter activity. An important paralog of this gene is SPNS3.

UniProtKB/Swiss-Prot for SPNS2 Gene

  • Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPNS2 Gene

Genomics for SPNS2 Gene

Regulatory Elements for SPNS2 Gene

Enhancers for SPNS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPNS2 on UCSC Golden Path with GeneCards custom track

Promoters for SPNS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPNS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPNS2 Gene

Chromosome:
17
Start:
4,498,834 bp from pter
End:
4,539,933 bp from pter
Size:
41,100 bases
Orientation:
Plus strand

Genomic View for SPNS2 Gene

Genes around SPNS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPNS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPNS2 Gene

Proteins for SPNS2 Gene

  • Protein details for SPNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW8-SPNS2_HUMAN
    Recommended name:
    Protein spinster homolog 2
    Protein Accession:
    Q8IVW8
    Secondary Accessions:
    • B9A1T3

    Protein attributes for SPNS2 Gene

    Size:
    549 amino acids
    Molecular mass:
    58044 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPNS2 Gene

Proteomics data for SPNS2 Gene at MOPED

Post-translational modifications for SPNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPNS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPNS2 Gene

Domains & Families for SPNS2 Gene

Protein Domains for SPNS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPNS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVW8

UniProtKB/Swiss-Prot:

SPNS2_HUMAN :
  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
Family:
  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
genes like me logo Genes that share domains with SPNS2: view

No data available for Gene Families for SPNS2 Gene

Function for SPNS2 Gene

Molecular function for SPNS2 Gene

UniProtKB/Swiss-Prot Function:
Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.
genes like me logo Genes that share phenotypes with SPNS2: view

Animal Models for SPNS2 Gene

MGI Knock Outs for SPNS2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPNS2 Gene

Localization for SPNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPNS2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPNS2 Gene COMPARTMENTS Subcellular localization image for SPNS2 gene
Compartment Confidence
lysosome 3
vacuole 3
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for SPNS2 Gene

Pathways & Interactions for SPNS2 Gene

SuperPathways for SPNS2 Gene

No Data Available

Interacting Proteins for SPNS2 Gene

Gene Ontology (GO) - Biological Process for SPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002260 lymphocyte homeostasis IEA --
GO:0003376 sphingosine-1-phosphate signaling pathway IEA,IBA --
GO:0006665 sphingolipid metabolic process IEA --
GO:0043029 T cell homeostasis IEA --
GO:0048073 regulation of eye pigmentation IEA --
genes like me logo Genes that share ontologies with SPNS2: view

No data available for Pathways by source and SIGNOR curated interactions for SPNS2 Gene

Drugs & Compounds for SPNS2 Gene

No Compound Related Data Available

Transcripts for SPNS2 Gene

Unigene Clusters for SPNS2 Gene

Spinster homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPNS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for SPNS2 Gene

GeneLoc Exon Structure for
SPNS2
ECgene alternative splicing isoforms for
SPNS2

Expression for SPNS2 Gene

mRNA expression in normal human tissues for SPNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPNS2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for SPNS2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPNS2 Gene



SOURCE GeneReport for Unigene cluster for SPNS2 Gene Hs.22824

genes like me logo Genes that share expression patterns with SPNS2: view

Protein tissue co-expression partners for SPNS2 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SPNS2 Gene

Orthologs for SPNS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPNS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPNS2 35
  • 91.8 (n)
  • 95.81 (a)
SPNS2 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPNS2 35
  • 90.03 (n)
  • 96.17 (a)
mouse
(Mus musculus)
Mammalia Spns2 35
  • 88.69 (n)
  • 96.77 (a)
Spns2 16
Spns2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spns2 35
  • 88.68 (n)
  • 96.3 (a)
oppossum
(Monodelphis domestica)
Mammalia SPNS2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPNS2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPNS2 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPNS2 35
  • 79.54 (n)
  • 94.31 (a)
SPNS2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spns2 35
  • 73.7 (n)
  • 84.44 (a)
Str.18139 35
zebrafish
(Danio rerio)
Actinopterygii spns2 35
  • 69.9 (n)
  • 74.79 (a)
spns2 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta spin 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spin-1 36
  • 35 (a)
ManyToMany
spin-2 36
  • 34 (a)
ManyToMany
spin-3 36
  • 33 (a)
ManyToMany
spin-4 36
  • 35 (a)
ManyToMany
wheat
(Triticum aestivum)
Liliopsida Ta.28328 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5353 36
  • 28 (a)
OneToMany
Species with no ortholog for SPNS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SPNS2 Gene

ENSEMBL:
Gene Tree for SPNS2 (if available)
TreeFam:
Gene Tree for SPNS2 (if available)

Paralogs for SPNS2 Gene

Paralogs for SPNS2 Gene

(2) SIMAP similar genes for SPNS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPNS2: view

Variants for SPNS2 Gene

Sequence variations from dbSNP and Humsavar for SPNS2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs184566 -- 4,499,508(+) TGGTC(C/T)CAGGC intron-variant
rs959279 -- 4,524,192(+) TCTTT(C/T)ACAAG intron-variant
rs974246 -- 4,501,046(-) ACAGG(C/T)CCCAG intron-variant
rs724809 -- 4,508,534(-) AATGC(C/T)GCTAG intron-variant
rs333111 -- 4,497,600(-) CGCTA(C/G)AGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPNS2 Gene

Variant ID Type Subtype PubMed ID
nsv833345 CNV Loss 17160897
nsv907605 CNV Loss 21882294
dgv3049n71 CNV Loss 21882294
dgv3050n71 CNV Loss 21882294
dgv3051n71 CNV Loss 21882294
esv1003136 CNV Gain 20482838

Variation tolerance for SPNS2 Gene

Residual Variation Intolerance Score: 12.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPNS2 Gene

Disorders for SPNS2 Gene

Relevant External Links for SPNS2

Genetic Association Database (GAD)
SPNS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPNS2

No disorders were found for SPNS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPNS2 Gene

Publications for SPNS2 Gene

  1. The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. (PMID: 19074308) Kawahara A. … Mochizuki N. (Science 2009) 3 4 67
  2. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. (PMID: 12815463) Yanagisawa H. … Yamamoto D. (Cell Death Differ. 2003) 2 3
  3. Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration. (PMID: 25330231) Bradley E. … Wang G. (PLoS ONE 2014) 3
  4. Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. (PMID: 25356849) Chen J. … Steel K.P. (PLoS Genet. 2014) 3
  5. Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. (PMID: 23180825) Nagahashi M. … Spiegel S. (FASEB J. 2013) 3

Products for SPNS2 Gene

Sources for SPNS2 Gene

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