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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SPNS2 Gene

protein-coding GIFtS: 40
GCID: GC17P004349

spinster homolog 2 (Drosophila)

Search for SPNS2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Spinster Homolog 2 (Drosophila)¹ ²
Protein Spinster Homolog 2²

External Ids:	HGNC: 26992¹	Entrez Gene: 124976²	Ensembl: ENSG00000183018⁷	OMIM: 612584⁵	UniProtKB: Q8IVW8³

Export aliases for SPNS2 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8

Function: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate

(S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development

and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby

regulating myocardial precursor migration

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SPNS2 gene promoter:
ER-alpha RP58 Pax-5 GATA-1 AREB6 FAC1 ARP-1 c-Myb Zic3
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for SPNS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPNS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2

SPNS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPNS2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P004349: view genomic region (about GC identifiers)

Start:	4,402,129 bp from pter	End:	4,443,228 bp from pter
Size:	41,100 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8 (See protein sequence)

Recommended Name: Protein spinster homolog 2

Size: 549 amino acids; 58044 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: B9A1T3

Explore the universe of human proteins at neXtProt for SPNS2: NX_Q8IVW8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IVW8

SPNS2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001118230.1

ENSEMBL proteins:

ENSP00000333292 ENSP00000461410

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	Uscn Proteins for SPNS2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

SPNS2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SPNS2 for domains About GeneDecksing

3 InterPro domains/families:

IPR020846 MFS_dom

IPR011701 MFS

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q8IVW8

ProtoNet protein and cluster: Q8IVW8

UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8

Similarity: Belongs to the major facilitator (TC 2.A.1) superfamily. Spinster (TC 2.A.1.49) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: SPNS2_HUMAN, Q8IVW8

Function: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate

(S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development

and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby

regulating myocardial precursor migration

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In Situ Assay
Products:

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Animal Models:
Mouse knock-outs for SPNS2: Spns2^{tm1b(KOMP)Wtsi} Spns2^tm1.2Nmoc
10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Spns2):

behavior/neurological	cardiovascular system	cellular	hearing/vestibular/ear	hematopoietic system
homeostasis/metabolism	immune system	pigmentation	skeleton	vision/eye

SPNS2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SPNS2

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006869	lipid transport	IEA	--
GO:0055085	transmembrane transport	IEA	--

SPNS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPNS2
Search CenterWatch for drugs/clinical trials and news about SPNS2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for SPNS2 gene:

NM_001124758.1

Unigene Cluster for SPNS2:

Spinster homolog 2 (Drosophila)

Hs.22824 [show with all ESTs]

Unigene Representative Sequence: NM_001124758

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000329078(uc002fxx.2) ENST00000571386 ENST00000576635 ENST00000571668

ENST00000573106 ENST00000573990 ENST00000570641 ENST00000570979(uc002fxy.2)

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		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate SPNS2 (see all 31):
		hsa-miR-579 hsa-miR-485-5p hsa-miR-631 hsa-let-7a-2* hsa-miR-578 hsa-miR-181a-2* hsa-miR-650 hsa-miR-3661

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB441165.1 BC041772.1 BC065221.1

16 DOTS entries:

DT.100798032 DT.100798044 DT.40231828 DT.95367109 DT.100798034 DT.100728624 DT.100798037 DT.100798038

DT.455190 DT.95153081 DT.95293132 DT.100717857 DT.100798040 DT.121003724 DT.95373349 DT.97853605

24/116 AceView cDNA sequences (see all 116):

AI268088 BM727337 AI183511 AW055312 BF111023 BX096396 AI184425 BE047248

CR602862 BM857149 AI355796 BE042416 AW089043 AI913186 AW450188 BM679233

AI124640 AW298213 BM670496 AA535318 AI222569 AW028876 AI244723 AI560219

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SPNS2 (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:							-		-						-		-		-
SP2:							-		-
SP3:							-		-						-		-		-
SP4:							-		-										-
SP5:																			-

ECgene alternative splicing isoforms for SPNS2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPNS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACACACCAG

About this image

SPNS2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SPNS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPNS2

SOURCE GeneReport for Unigene cluster: Hs.22824

SABiosciences Custom PCR Arrays for SPNS2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPNS2 gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SPNS2¹	spinster homolog 2 (Drosophila)	78.59(n) 92.89(a)		417492 XM_415740.3 XP_415740.3
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.18139²	Transcribed sequence with weak similarity to protein more	81.22(n)		AL959825.2
zebrafish (Danio rerio)	Actinopterygii	spns2¹	spinster homolog 2 (Drosophila)	68.74(n) 73.35(a)		568117 NM_001083847.1 NP_001077316.1
fruit fly (Drosophila melanogaster)	Insecta	spin⁶	spinster	32(a)	1 → many	2R(12012488-12025743)
worm (Caenorhabditis elegans)	Secernentea	Y111B2A.19⁶ C13C4.5⁶ (see all 4)	Protein C13C4.5 (see all 4)	35(a) 34(a) (see all 4)	many ↔ many many ↔ many (see all 4)	III(12688172-12697445) V(12114972-12117542)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G65687⁶ AT2G22730⁶ (see all 3)	major facilitator protein (see all 3)	22(a) 21(a) (see all 3)	many ↔ many many ↔ many (see all 3)	5(26269856-26272899) 2(9660964-9664133)
rice (Oryza sativa)	Liliopsida	--	transporter, major facilitator family, putative, e...	18(a)	1 → many	4(26114305-26122622)

ENSEMBL Gene Tree for SPNS2 (if available)
TreeFam Gene Tree for SPNS2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SPNS2 gene

SPNS3² SPNS1²

2 SIMAP similar genes for SPNS2 using alignment to 2 protein entries: SPNS2_HUMAN (see all proteins):

SPNS1 SPNS3

SPNS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs115682325^1,2	C,F,	--	4400260(+)	`AAGAGA/CATGCT`	1	--	us2k¹		1		WA	118
rs141565293^1,2		--	4400283(+)	`AAGGCC/TGAAAG`	1	--	us2k¹		0	--	--	--	--
rs112687627^1,2	C,	--	4400284(+)	`AGGCCG/AAAAGT`	1	--	us2k¹		2		NA	122
rs59165259^1,2	C,	--	4400304(+)	`GACAGG/CACTGT`	1	--	us2k¹		2		WA	120
rs11657464^1,2	C,F,A,H,	--	4400333(+)	`TTTTGA/GGGCAC`	1	--	us2k¹		12		NA WA CSA EA	376
rs192228351^1,2		--	4400338(+)	`GGGCAC/TGGGAA`	1	--	us2k¹		0	--	--	--	--
rs333113^1,2	C,F,A,H,	--	4400356(+)	`CTGGGG/CTTGGG`	1	--	us2k¹		16		NS EA NA WA CSA	853
rs75175068^1,2		--	4400372(+)	`AGTTGC/TGGTTG`	1	--	us2k¹		0	--	--	--	--
rs8074965^1,2	C,F,	--	4400384(+)	`GCCTCC/ATTCAC`	1	--	us2k¹		7		NA WA CSA	247
rs11657785^1,2	C,F,A,H,	--	4400392(+)	`CACCAT/CTAGAC`	1	--	us2k¹		7		NA	134

HapMap Linkage Disequilibrium report for SPNS2 (4402129 - 4443228 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SPNS2
1 CNV: 4984

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPNS2

DNA2.0 Custom Variant and Variant Library Synthesis for SPNS2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SPNS2 for disorders About MalaCards

SPNS2 for disorders About GeneDecksing

OMIM gene information: 612584 OMIM disorders: --

Export disorders for SPNS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SPNS2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPNS2)

Utopia: connect your pdf to the dynamic
world of online information

The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. (PubMed id 19074308)^{1, 2} Kawahara A....Mochizuki N. (2009)
HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. (PubMed id 12815463)^{1, 3} Yanagisawa H.... Yamamoto D. (2003)
The sphingosine 1-phosphate transporter, SPNS2, funct ions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. (PubMed id 21084291)¹ Hisano Y....Nishi T. (2011)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 124976	HGNC: 26992	AceView: LOC124976	Ensembl:ENSG00000183018	euGenes: HUgn124976
ECgene: SPNS2	H-InvDB: SPNS2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SPNS2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SPNS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SPNS2 gene:
Search GeneIP for patents involving SPNS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
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	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SPNS2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPNS2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPNS2
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SPNS2		OriGene 3'-UTR Clone for SPNS2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPNS2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPNS2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SPNS2		OriGene Custom Protein Services for SPNS2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPNS2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPNS2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPNS2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPNS2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPNS2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPNS2

	GenScript Custom Purified and Recombinant Proteins Services for SPNS2		GenScript cDNA clones with any tag delivered in your preferred vector for SPNS2
	GenScript Custom Assay Services for SPNS2		GenScript Custom Superior Antibodies Services for SPNS2
	GenScript Custom overexpressing Cell Line Services for SPNS2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in SPNS2 promoter
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	RT² qPCR Primer Assay in human, mouse / rat SPNS2
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for SPNS2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SPNS2
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPNS2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for SPNS2
	Browse SwitchGear Promoter luciferase reporter plasmids for SPNS2

Search ThermoFisher Antibodies for SPNS2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPNS2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SPNS2 gene at Home site.

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SPNS2 Gene

spinster homolog 2 (Drosophila)

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Export list of displayed genes

SPNS2 Gene

spinster homolog 2 (Drosophila)

Aliasesfor SPNS2 gene

Summariesfor SPNS2 gene

Genomic Viewsfor SPNS2 gene

Proteinsfor SPNS2 gene

Protein Domains /Familiesfor SPNS2 gene

Functionfor SPNS2 gene

Pathways & Interactionsfor SPNS2 gene

Drugs & Compoundsfor SPNS2 gene

Transcriptsfor SPNS2 gene

Expression for SPNS2 gene

Orthologsfor SPNS2 gene

Paralogsfor SPNS2 gene

Genomic Variantsfor SPNS2 gene

Disorders / Diseasesfor SPNS2 gene

Publicationsfor SPNS2 gene

External Searches for SPNS2 gene

Genome Databases showing SPNS2 gene

Other Databases showing SPNS2 gene

Specialized Databases showing SPNS2 gene

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Productsfor SPNS2 gene

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for SPNS2 gene

Summaries
for SPNS2 gene

Genomic Views
for SPNS2 gene

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for SPNS2 gene

Protein Domains /
Families
for SPNS2 gene

Function
for SPNS2 gene

Pathways & Interactions
for SPNS2 gene

Drugs & Compounds
for SPNS2 gene

Transcripts
for SPNS2 gene

Expression
for SPNS2 gene

Orthologs
for SPNS2 gene

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for SPNS2 gene

Genomic Variants
for SPNS2 gene

Disorders / Diseases
for SPNS2 gene

Publications
for SPNS2 gene

Intellectual Property
for SPNS2 gene

Products
for SPNS2 gene