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Aliases for SPNS2 Gene

Aliases for SPNS2 Gene

  • Spinster Homolog 2 (Drosophila) 2 3

External Ids for SPNS2 Gene

Previous GeneCards Identifiers for SPNS2 Gene

  • GC17P004349
  • GC17P004402

Summaries for SPNS2 Gene

GeneCards Summary for SPNS2 Gene

SPNS2 (Spinster Homolog 2 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is SPNS3.

UniProtKB/Swiss-Prot for SPNS2 Gene

  • Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPNS2 Gene

Genomics for SPNS2 Gene

Regulatory Elements for SPNS2 Gene

Genomic Location for SPNS2 Gene

Start:
4,498,834 bp from pter
End:
4,539,933 bp from pter
Size:
41,100 bases
Orientation:
Plus strand

Genomic View for SPNS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPNS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPNS2 Gene

Proteins for SPNS2 Gene

  • Protein details for SPNS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW8-SPNS2_HUMAN
    Recommended name:
    Protein spinster homolog 2
    Protein Accession:
    Q8IVW8
    Secondary Accessions:
    • B9A1T3

    Protein attributes for SPNS2 Gene

    Size:
    549 amino acids
    Molecular mass:
    58044 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPNS2 Gene

Proteomics data for SPNS2 Gene at MOPED

Post-translational modifications for SPNS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPNS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPNS2 Gene

Domains for SPNS2 Gene

Protein Domains for SPNS2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SPNS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVW8

UniProtKB/Swiss-Prot:

SPNS2_HUMAN :
  • Q8IVW8
Family:
  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
genes like me logo Genes that share domains with SPNS2: view

No data available for Gene Families for SPNS2 Gene

Function for SPNS2 Gene

Molecular function for SPNS2 Gene

UniProtKB/Swiss-Prot Function: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration.

Gene Ontology (GO) - Molecular Function for SPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity --
GO:0046624 sphingolipid transporter activity IBA --
genes like me logo Genes that share ontologies with SPNS2: view
genes like me logo Genes that share phenotypes with SPNS2: view

Animal Models for SPNS2 Gene

MGI Knock Outs for SPNS2:

miRNA for SPNS2 Gene

miRTarBase miRNAs that target SPNS2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SPNS2 Gene

Localization for SPNS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPNS2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPNS2 Gene COMPARTMENTS Subcellular localization image for SPNS2 gene
Compartment Confidence
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0031982 vesicle IBA --
genes like me logo Genes that share ontologies with SPNS2: view

Pathways for SPNS2 Gene

SuperPathways for SPNS2 Gene

No Data Available

Interacting Proteins for SPNS2 Gene

Gene Ontology (GO) - Biological Process for SPNS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001782 B cell homeostasis IEA --
GO:0002260 lymphocyte homeostasis --
GO:0002920 regulation of humoral immune response IEA --
GO:0003376 sphingosine-1-phosphate signaling pathway IBA --
GO:0006665 sphingolipid metabolic process IEA --
genes like me logo Genes that share ontologies with SPNS2: view

No data available for Pathways by source for SPNS2 Gene

Transcripts for SPNS2 Gene

mRNA/cDNA for SPNS2 Gene

Unigene Clusters for SPNS2 Gene

Spinster homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPNS2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - -
SP3: - - - - -
SP4: - - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for SPNS2 Gene

GeneLoc Exon Structure for
SPNS2
ECgene alternative splicing isoforms for
SPNS2

Expression for SPNS2 Gene

mRNA expression in normal human tissues for SPNS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPNS2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPNS2 Gene

SOURCE GeneReport for Unigene cluster for SPNS2 Gene Hs.22824

genes like me logo Genes that share expressions with SPNS2: view

No data available for mRNA Expression by UniProt/SwissProt for SPNS2 Gene

Orthologs for SPNS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPNS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPNS2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPNS2 35
  • 91.8 (n)
  • 95.81 (a)
SPNS2 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPNS2 35
  • 90.03 (n)
  • 96.17 (a)
mouse
(Mus musculus)
Mammalia Spns2 35
  • 88.69 (n)
  • 96.77 (a)
Spns2 16
Spns2 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPNS2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPNS2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spns2 35
  • 88.68 (n)
  • 96.3 (a)
chicken
(Gallus gallus)
Aves SPNS2 35
  • 79.54 (n)
  • 94.31 (a)
SPNS2 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spns2 35
  • 73.7 (n)
  • 84.44 (a)
Str.18139 35
zebrafish
(Danio rerio)
Actinopterygii spns2 35
  • 69.9 (n)
  • 74.79 (a)
spns2 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta spin 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea spin-1 36
  • 35 (a)
ManyToMany
spin-2 36
  • 34 (a)
ManyToMany
spin-3 36
  • 33 (a)
ManyToMany
spin-4 36
  • 35 (a)
ManyToMany
wheat
(Triticum aestivum)
Liliopsida Ta.28328 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5353 36
  • 28 (a)
OneToMany
Species with no ortholog for SPNS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for SPNS2 Gene

ENSEMBL:
Gene Tree for SPNS2 (if available)
TreeFam:
Gene Tree for SPNS2 (if available)

Paralogs for SPNS2 Gene

Paralogs for SPNS2 Gene

Selected SIMAP similar genes for SPNS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SPNS2: view

Variants for SPNS2 Gene

Sequence variations from dbSNP and Humsavar for SPNS2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs184566 -- 4,499,508(+) TGGTC(C/T)CAGGC intron-variant
rs333111 -- 4,497,600(-) CGCTA(C/G)AGGCT upstream-variant-2KB
rs333112 -- 4,497,559(+) CTTCA(C/T)CAGAT upstream-variant-2KB
rs333113 -- 4,497,061(+) CTGGG(C/G)TTGGG upstream-variant-2KB
rs724809 -- 4,508,534(-) AATGC(C/T)GCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPNS2 Gene

Variant ID Type Subtype PubMed ID
nsv833345 CNV Loss 17160897
nsv907605 CNV Loss 21882294
dgv3049n71 CNV Loss 21882294
dgv3050n71 CNV Loss 21882294
dgv3051n71 CNV Loss 21882294
esv1003136 CNV Gain 20482838

Relevant External Links for SPNS2 Gene

HapMap Linkage Disequilibrium report
SPNS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPNS2 Gene

Disorders for SPNS2 Gene

Relevant External Links for SPNS2

Genetic Association Database (GAD)
SPNS2
genes like me logo Genes that share disorders with SPNS2: view

No data available for UniProtKB/Swiss-Prot for SPNS2 Gene

Publications for SPNS2 Gene

  1. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. (PMID: 12815463) Yanagisawa H. … Yamamoto D. (Cell Death Differ. 2003) 2 3
  2. The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. (PMID: 19074308) Kawahara A. … Mochizuki N. (Science 2009) 3 4
  3. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. (PMID: 21084291) Hisano Y. … Nishi T. (J. Biol. Chem. 2011) 3
  4. Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. (PMID: 23180825) Nagahashi M. … Spiegel S. (FASEB J. 2013) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SPNS2 Gene

Sources for SPNS2 Gene

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