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Aliases for SPNS1 Gene

Aliases for SPNS1 Gene

  • Spinster Homolog 1 (Drosophila) 2 3
  • SPIN1 3 4 6
  • Spinster-Like Protein 1 3 4
  • HSpin1 3 4
  • Protein Spinster Homolog 1 3
  • PP2030 3
  • SPINL 3
  • LAT 3
  • Nrs 3

External Ids for SPNS1 Gene

Previous GeneCards Identifiers for SPNS1 Gene

  • GC16P028897
  • GC16P026853

Summaries for SPNS1 Gene

GeneCards Summary for SPNS1 Gene

SPNS1 (Spinster Homolog 1 (Drosophila)) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Signaling by FGFR. An important paralog of this gene is SPNS3.

UniProtKB/Swiss-Prot for SPNS1 Gene

  • Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPNS1 Gene

Genomics for SPNS1 Gene

Regulatory Elements for SPNS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SPNS1 Gene

28,974,221 bp from pter
28,984,548 bp from pter
10,328 bases
Plus strand

Genomic View for SPNS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPNS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPNS1 Gene

Proteins for SPNS1 Gene

  • Protein details for SPNS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein spinster homolog 1
    Protein Accession:
    Secondary Accessions:
    • B5MDM9
    • Q6P182
    • Q71RB5
    • Q7L541
    • Q86VU7
    • Q8N953
    • Q8TCS5
    • Q9BRN5

    Protein attributes for SPNS1 Gene

    528 amino acids
    Molecular mass:
    56630 Da
    Quaternary structure:
    • Interacts with BCL2 and BCL2L1.
    • Sequence=AAQ15259.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15259.1; Type=Frameshift; Positions=97; Evidence={ECO:0000305};

    Alternative splice isoforms for SPNS1 Gene


neXtProt entry for SPNS1 Gene

Proteomics data for SPNS1 Gene at MOPED

Post-translational modifications for SPNS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for SPNS1 Gene

Domains for SPNS1 Gene

Protein Domains for SPNS1 Gene


Suggested Antigen Peptide Sequences for SPNS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
  • Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.
genes like me logo Genes that share domains with SPNS1: view

No data available for Gene Families for SPNS1 Gene

Function for SPNS1 Gene

Molecular function for SPNS1 Gene

UniProtKB/Swiss-Prot Function:
Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death.

Gene Ontology (GO) - Molecular Function for SPNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005515 protein binding IPI 12815463
GO:0022857 transmembrane transporter activity --
GO:0046624 sphingolipid transporter activity IBA --
genes like me logo Genes that share ontologies with SPNS1: view
genes like me logo Genes that share phenotypes with SPNS1: view

Animal Model Products

miRNA for SPNS1 Gene

miRTarBase miRNAs that target SPNS1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SPNS1 Gene

Localization for SPNS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPNS1 Gene

Mitochondrion inner membrane; Multi-pass membrane protein. Note=Colocalizes with SDHB.

Subcellular locations from

Jensen Localization Image for SPNS1 Gene COMPARTMENTS Subcellular localization image for SPNS1 gene
Compartment Confidence
mitochondrion 5
plasma membrane 3
cytosol 2
golgi apparatus 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SPNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0031982 vesicle IBA --
genes like me logo Genes that share ontologies with SPNS1: view

Pathways for SPNS1 Gene

genes like me logo Genes that share pathways with SPNS1: view

Gene Ontology (GO) - Biological Process for SPNS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003376 sphingosine-1-phosphate signaling pathway IBA --
GO:0006810 transport --
GO:0006869 lipid transport IEA --
GO:0040011 locomotion IBA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SPNS1: view

Transcripts for SPNS1 Gene

Unigene Clusters for SPNS1 Gene

Spinster homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPNS1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPNS1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: -
SP3: -
SP4: - - - - - -
SP5: -
SP6: - - - - -
SP7: -
SP8: - - - - - - - -
SP9: -

Relevant External Links for SPNS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPNS1 Gene

mRNA expression in normal human tissues for SPNS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SPNS1 Gene

This gene is overexpressed in Adrenal (13.0), Peripheral blood mononuclear cells (10.9), Monocytes (7.3), and Lung (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPNS1 Gene

SOURCE GeneReport for Unigene cluster for SPNS1 Gene Hs.617449

genes like me logo Genes that share expressions with SPNS1: view

Expression partners for SPNS1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPNS1 Gene

Orthologs for SPNS1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SPNS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SPNS1 35
  • 91.04 (n)
  • 94.13 (a)
SPNS1 36
  • 94 (a)
(Canis familiaris)
Mammalia SPNS1 35
  • 91.25 (n)
  • 95.75 (a)
SPNS1 36
  • 89 (a)
(Mus musculus)
Mammalia Spns1 35
  • 87.88 (n)
  • 93.56 (a)
Spns1 16
Spns1 36
  • 94 (a)
(Pan troglodytes)
Mammalia SPNS1 35
  • 99.81 (n)
  • 99.81 (a)
SPNS1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Spns1 35
  • 87.75 (n)
  • 93.37 (a)
(Monodelphis domestica)
Mammalia SPNS1 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia SPNS1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia SPNS1 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia spns1 35
  • 69.92 (n)
  • 70.93 (a)
Str.16886 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16646 35
(Danio rerio)
Actinopterygii spinl 35
spns1 35
  • 64.81 (n)
  • 68.39 (a)
spns1 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006346 35
  • 56.05 (n)
  • 50.78 (a)
fruit fly
(Drosophila melanogaster)
Insecta spin 35
  • 54.4 (n)
  • 52.14 (a)
spin 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea C13C4.5 35
  • 45.99 (n)
  • 42.73 (a)
spin-1 36
  • 36 (a)
spin-2 36
  • 38 (a)
spin-3 36
  • 36 (a)
spin-4 36
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G65687 35
  • 39.16 (n)
  • 32.91 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12624 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5353 36
  • 33 (a)
Species with no ortholog for SPNS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SPNS1 Gene

Gene Tree for SPNS1 (if available)
Gene Tree for SPNS1 (if available)

Paralogs for SPNS1 Gene

Paralogs for SPNS1 Gene

(2) SIMAP similar genes for SPNS1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SPNS1: view

Variants for SPNS1 Gene

Sequence variations from dbSNP and Humsavar for SPNS1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs150930495 -- 28,982,654(+) TCTGG(C/T)TCTTC intron-variant
rs370216778 -- 28,982,810(+) TTCCA(A/T)GTGTT intron-variant
rs534193399 -- 28,982,701(+) CTGTG(C/T)TCAGT intron-variant
rs552454447 -- 28,982,790(+) AGCTG(G/T)GAACA intron-variant
VAR_035157 -

Structural Variations from Database of Genomic Variants (DGV) for SPNS1 Gene

Variant ID Type Subtype PubMed ID
dgv842e1 CNV Complex 17122850
nsv905702 CNV Gain+Loss 21882294
nsv518648 CNV Loss 19592680
nsv519100 CNV Gain 19592680
nsv457480 CNV Gain 19166990

Relevant External Links for SPNS1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPNS1 Gene

Disorders for SPNS1 Gene

No disorders were found for SPNS1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for SPNS1 Gene

Publications for SPNS1 Gene

  1. HSpin1, a transmembrane protein interacting with Bcl-2/Bcl-xL, induces a caspase-independent autophagic cell death. (PMID: 12815463) Yanagisawa H. … Yamamoto D. (Cell Death Differ. 2003) 2 3 4
  2. Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster. (PMID: 11340170) Nakano Y. … Yamamoto D. (Mol. Cell. Biol. 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3
  5. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PMID: 21903422) Li S. … Dorf M.E. (Immunity 2011) 3

Products for SPNS1 Gene

Sources for SPNS1 Gene

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