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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPN Gene

protein-coding   GIFtS: 61
GCID: GC16P029674

Sialophorin

(Previous names: sialophorin (gpL115, leukosialin, CD43))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Sialophorin3     GALGP2 3
sialophorin1 2     LSN2 5
CD432 3 5     GPL1152
Sialophorin (GpL115, Leukosialin, CD43)1 2     galactoglycoprotein2
leukosialin1 2     Galactoglycoprotein3
Leukocyte Sialoglycoprotein2 3     CD43 Antigen3

External Ids:    HGNC: 112491   Entrez Gene: 66932   Ensembl: ENSG000001974717   OMIM: 1821605   UniProtKB: P161503   

Export aliases for SPN gene to outside databases

Previous GC identifers: GC16M028745 GC16P029998 GC16P029672 GC16P029712 GC16P029581 GC16P027335


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SPN Gene:
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes,
monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved
in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC
(antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response.
(provided by RefSeq, Sep 2011)

GeneCards Summary for SPN Gene: 
SPN (sialophorin) is a protein-coding gene. Diseases associated with SPN include myeloid sarcoma, and richter's syndrome, and among its related super-pathways are Platelet activation, signaling and aggregation. GO annotations related to this gene include transmembrane signaling receptor activity and bacterial cell surface binding.

UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150
Function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical
properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an
extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains
to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is
actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory
role in adaptive immune response (By similarity)

Gene Wiki entry for SPN (CD43) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPN gene promoter:
         p53   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPN promoter sequence
   Search SABiosciences Chromatin IP Primers for SPN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029674:  view genomic region     (about GC identifiers)

Start:
29,674,300 bp from pter      End:
29,682,187 bp from pter
Size:
7,888 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150 (See protein sequence)
Recommended Name: Leukosialin precursor  
Size: 400 amino acids; 40322 Da
Subunit: Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for SPN: NX_P16150

Explore proteomics data for SPN at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P16150

  • SPN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SPN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001025459.1  NP_003114.1  

    ENSEMBL proteins: 
     ENSP00000378787   ENSP00000412907   ENSP00000455266   ENSP00000353238  
    Reactome Protein details: P16150
    Human Recombinant Protein Products for SPN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SPN
    OriGene Protein Over-expression Lysate for SPN
    OriGene MassSpec for SPN 
    OriGene Custom Protein Services for SPN
    GenScript Custom Purified and Recombinant Proteins Services for SPN
    Novus Biologicals SPN Proteins
    Novus Biologicals SPN Lysates
    Sino Biological Recombinant Protein for SPN
    Sino Biological Cell Lysate for SPN 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPN 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001931uropod IEA--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA10899905
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--

    SPN for ontologies           About GeneDecksing



    SPN Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of SPN
    R&D Systems Antibodies for SPN (CD43)
    OriGene Antibodies for SPN
    OriGene Custom Antibody Services for SPN
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    Novus Biologicals SPN Antibodies
    Abcam antibodies for SPN
    Cloud-Clone Corp. Antibodies for SPN 
    ThermoFisher Antibody for SPN
    LSBio Antibodies in human, mouse, rat for SPN 

    Assay Products for SPN: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems Proteome Profiler Antibody Arrays for SPN (CD43)
    GenScript Custom Assay Services for SPN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPN 
    Cloud-Clone Corp. CLIAs for SPN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules

    ProtoNet protein and cluster: P16150


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEUK_HUMAN, P16150
    Function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical
    properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an
    extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains
    to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is
    actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory
    role in adaptive immune response (By similarity)

         Genatlas biochemistry entry for SPN:
    sialophorin (gpl115,leukosialin) binding ezrin pradixin/moesin (ERM) proteins

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS1683685
    GO:0005515protein binding ----
    GO:0051635bacterial cell surface binding ----
         
    SPN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPN:
     Increased HPV18 LCR reporter a 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spn):
     cellular  hematopoietic system  immune system  tumorigenesis 

    SPN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Spntm1Bam for SPN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SPN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPN 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPN
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SPN (see all 11):
    hsa-miR-4288 hsa-miR-1224-3p hsa-miR-513a-3p hsa-miR-632 hsa-miR-3160-3p hsa-miR-1248 hsa-miR-877* hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPN

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of SPN

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SPN (see all 14)
    OriGene ORF clones in mouse, rat for SPN
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    GenScript: all cDNA clones in your preferred vector: SPN (NM_004158)
    Sino Biological Human cDNA Clone for SPN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPN
    Sirion Biotech Customized lentivirus for stable overexpression of SPN 
                         Customized lentivirus expression plasmids for stable overexpression of SPN 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SPN About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Platelet activation, signaling and aggregation
    Hemostasis0.43
    2Epstein-Barr virus infection
    Epstein-Barr virus infection
    3Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    4Basigin interactions
    Basigin interactions
    5Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for SPN
        Hemostasis
    Basigin interactions
    Cell surface interactions at the vascular wall


    2         Kegg Pathways  (Kegg details for SPN):
        Cell adhesion molecules (CAMs)
    Epstein-Barr virus infection


    SPN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for SPN (P161503 ENSP000003532384) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS1P093823, ENSP000002159094I2D: score=4 STRING: ENSP00000215909
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    ICAM1P053623, ENSP000002648324I2D: score=2 STRING: ENSP00000264832
    SIGLEC1Q9BZZ23, ENSP000003411414I2D: score=2 STRING: ENSP00000341141
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001562response to protozoan IEA--
    GO:0001808negative regulation of type IV hypersensitivity IEA--
    GO:0006935chemotaxis TAS10753822
    GO:0006955immune response TAS2023632
    GO:0006968cellular defense response TAS1683685

    SPN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPN (LEUK)

    10/14 Novoseek inferred chemical compound relationships for SPN gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polylactosamine 54.7 1 2007580 (1)
    sialic acid 48.3 9 7822786 (1), 9278308 (1), 10458318 (1), 7662987 (1) (see all 5)
    cytochalasin b 43.5 3 9224764 (2), 1358626 (1)
    fmlp 37.3 3 1358626 (2)
    pmsf 36 4 1358626 (2), 9241533 (1)
    paraffin 20 3 10360820 (2), 8037168 (1)
    polysaccharide 15.5 3 1371528 (1), 8702529 (1), 16269612 (1)
    leucine 6.2 1 18614175 (1)
    threonine 4.96 1 14552419 (1)
    tyrosine 4.56 6 14516796 (2), 8898942 (1), 9473499 (1)

    Search CenterWatch for drugs/clinical trials and news about SPN / LEUK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SPN gene (2 alternative transcripts): 
    NM_001030288.2  NM_003123.4  

    Unigene Cluster for SPN:

    Sialophorin
    Hs.632188  [show with all ESTs]
    Unigene Representative Sequence: NM_001030288
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395389 ENST00000436527 ENST00000563039 ENST00000360121(uc002dtm.3 uc002dtn.3)


    miRNA
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    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SPN (see all 11):
    hsa-miR-4288 hsa-miR-1224-3p hsa-miR-513a-3p hsa-miR-632 hsa-miR-3160-3p hsa-miR-1248 hsa-miR-877* hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    OriGene ORF clones in mouse, rat for SPN
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    GenScript: all cDNA clones in your preferred vector: SPN (NM_004158)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPN
    Sirion Biotech Customized lentivirus for stable overexpression of SPN 
                         Customized lentivirus expression plasmids for stable overexpression of SPN 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPN

    Additional mRNA sequence: 

    AK292626.1 AK313750.1 BC012350.1 BC035510.1 J04536.1 X60502.1 

    10 DOTS entries:

    DT.209865  DT.97792987  DT.120696486  DT.120695789  DT.120698081  DT.100019862  DT.100804517  DT.120695401 
    DT.120696423  DT.95292854 

    24/264 AceView cDNA sequences (see all 264):

    AW059610 J04536 CR608816 BP373131 AW263079 AA343173 CR594408 BI822033 
    BG327095 BC010033 BG576832 AL531128 BC012350 BI870607 BM711970 AA309681 
    BQ223326 AA421525 AA421560 NM_014298 CR603957 CR600977 BU501515 AW293885 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPN expression in normal human tissues (normalized intensities)      SPN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCGTAAT
    SPN Expression
    About this image


    SPN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 13 entries
             B-cell Progenitor Cells Peripheral Blood
             Hematopoietic progenitor cells ( Generation of hematopoietic progenitor cells and...
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Lower Urinary Tract (Urinary System)
             bladder   

    See SPN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPN

    SOURCE GeneReport for Unigene cluster: Hs.632188

    UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150
    Tissue specificity: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas

        SABiosciences Expression via Pathway-Focused PCR Array including SPN: 
              Apoptosis 384HT in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SPN gene from 2/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spn1 , 5 sialophorin1, 5 64.07(n)1
    55.38(a)1
      7 (69.35 cM)5
    207371  NM_001037810.11  NP_001032899.11 
     1271322325 
    lizard
    (Anolis carolinensis)
    Reptilia SPN6
    sialophorin
    18(a)
    1 ↔ 1
    GL343606.1(125004-126146)


    ENSEMBL Gene Tree for SPN (if available)
    TreeFam Gene Tree for SPN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 SNPs in SPN are shown (see all 245)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503159171,2
    C--29672367(+) TGCCTC/TGGCCT 1 -- us2k10--------
    rs1379703131,2
    --29672479(+) CGCCAC/TTTATA 1 -- us2k10--------
    rs80620821,2
    C,F,A,H--29672582(+) tgtgcA/Gcttaa 2 -- us2k121Minor allele frequency- G:0.21NS EA NA WA CSA 2347
    rs1147943591,2
    C,F--29672708(+) AGGAAG/ATCTGT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1910203431,2
    --29672728(+) TTCTGC/TAGCCC 2 -- us2k10--------
    rs1423876341,2
    --29672753(+) CTTTGC/TTCCTG 2 -- us2k10--------
    rs735283141,2
    C,F--29672766(+) TCCCTC/TATCCC 2 -- us2k12Minor allele frequency- T:0.11WA 120
    rs37642751,2
    C,F,A,H--29672982(+) AGCACA/CCCCGA 2 -- us2k120Minor allele frequency- C:0.29NS EA NA WA CSA 2342
    rs1821255451,2
    --29673081(+) CGGTGA/CAGGCC 2 -- us2k10--------
    rs37642761,2
    C,F,A,H--29673203(+) tcctgT/Cggctc 2 -- us2k132Minor allele frequency- C:0.47NS EA NA WA CSA 3201

    HapMap Linkage Disequilibrium report for SPN (29674300 - 29682187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPN:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833183CNV Loss17160897
    dgv34n68CNV Loss17160897
    dgv845e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182160    OMIM disorders: --

    20/30 diseases for SPN (see all 30):    About MalaCards
    myeloid sarcoma    richter's syndrome    adenoid cystic carcinoma    wiskott-aldrich syndrome
    marginal zone b-cell lymphoma    eczema    b-cell chronic lymphocytic leukemia    myelodysplastic syndromes
    adenoiditis    b-cell lymphomas    atopy    chronic lymphocytic leukemia
    thrombocytopenia    non-hodgkin lymphoma    hodgkin's lymphoma    human t-cell leukemia virus type 1
    influenza    adenoma    sarcoma    t-cell leukemia

    1 disease from the University of Copenhagen DISEASES database for SPN:
    Wiskott-Aldrich syndrome

    SPN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/20 Novoseek inferred disease relationships for SPN gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 79.7 14 2023632 (2), 8421057 (1), 2223062 (1), 1683685 (1) (see all 8)
    lymphoma lymphocytic 52.1 1 8037168 (1)
    colon carcinoma 35.7 4 9111064 (1), 12820726 (1), 7775421 (1), 12499775 (1)
    immunodeficiency 33.8 11 7964449 (2), 8554898 (1), 1976735 (1), 2023632 (1) (see all 7)
    eczema 27.1 2 7645397 (1)
    lymphoma t-cell 23.5 3 1976735 (1)
    adenoma 18.6 7 10360820 (3), 17891181 (1), 9299561 (1), 12499775 (1)
    myelodysplastic syndromes 17.9 2 10602163 (1), 10834507 (1)
    necrosis 8.35 3 12431190 (1), 7621589 (1), 9129210 (1)
    tumors 2.36 12 17891181 (4), 18227725 (2), 12431190 (1), 12820726 (1) (see all 7)

    Genetic Association Database (GAD): SPN
    Human Genome Epidemiology (HuGE) Navigator: SPN (4 documents)

    Export disorders for SPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPN gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with SPN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. (PubMed id 2784859)1, 2, 3 Shelley C.S.... Whitehead D.A.S. (1989)
    2. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. (PubMed id 2521952)1, 2, 3 Pallant A....Frelinger J.G. (1989)
    3. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). (PubMed id 1731338)1, 2, 9 Schmid K.... Remold-O'Donnell E. (1992)
    4. Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. (PubMed id 2241892)1, 2, 9 Shelley C.S.... Whitehead D.A.S. (1990)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. (PubMed id 1827122)1, 2 Kudo S. and Fukuda M. (1991)
    7. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. (PubMed id 17996943)1, 9 Khunkaewla P....Stockinger H. (2008)
    8. Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. (PubMed id 10753822)1, 9 Seveau S....Halbwachs-Mecarelli L. (2000)
    9. CD43 promotes cell growth and helps to evade FAS-medi ated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF. (PubMed id 17891181)1, 9 Kadaja-Saarepuu L....Maimets T. (2008)
    10. The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. (PubMed id 18586676)1, 9 Mambole A....Halbwachs-Mecarelli L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6693 HGNC: 11249 AceView: SPNandQPRT Ensembl:ENSG00000197471 euGenes: HUgn6693
    ECgene: SPN Kegg: 6693 H-InvDB: SPN

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SPN gene:
    Search GeneIP for patents involving SPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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