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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPN Gene

protein-coding   GIFtS: 59
GCID: GC16P029674

sialophorin

(Previous names: sialophorin (gpL115, leukosialin, CD43) )
 Explore 29 diseases affiliated with
SPN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SPN    

Aliases
for SPN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Sialophorin3     Leukocyte Sialoglycoprotein2 3
Sialophorin3     GALGP2 3
CD431 2 3 5     Galactoglycoprotein3
LSN1 2 5     Leukosialin1
GPL1151 2     Galactoglycoprotein3
Sialophorin (GpL115, Leukosialin, CD43)1 2     CD43 Antigen3

External Ids:    HGNC: 112491   Entrez Gene: 66932   Ensembl: ENSG000001974717   OMIM: 1821605   UniProtKB: P161503   

Export aliases for SPN gene to outside databases

Previous GC identifers: GC16M028745 GC16P029998 GC16P029672 GC16P029712 GC16P029581 GC16P027335


Summaries
for SPN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SPN:
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes,
monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in
T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting
cell) contact site, suggesting a negative regulatory role in adaptive immune response. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150
Function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical
properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended
rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be
accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively
removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in
adaptive immune response (By similarity)

Gene Wiki entry for SPN (CD43)


Genomic Views
for SPN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPN gene promoter:
         p53   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SPN promoter sequence
   Search SABiosciences Chromatin IP Primers for SPN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029674:  view genomic region     (about GC identifiers)

Start:
 29,674,300 bp from pter      End:
 29,682,187 bp from pter
Size:
 7,888 bases      Orientation:
 plus strand

Proteins
for SPN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150 (See protein sequence)
Recommended Name: Leukosialin precursor  
Size: 400 amino acids; 40322 Da
Subunit: Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein

Explore the universe of human proteins at neXtProt for SPN: NX_P16150

Post-translational modifications:

  • Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P16150

    • SPN Protein expression data from MOPED and PaxDb:    About this image 
    SPN Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001025459.1  NP_003114.1  

    ENSEMBL proteins: 
     ENSP00000378787   ENSP00000412907   ENSP00000455266   ENSP00000353238  
    Reactome Protein details: P16150
    Human Recombinant Protein Products for SPN: 
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    OriGene Purified Protein: SPN
    OriGene Protein Over-expression Lysate (see all 3): SPN
    OriGene Custom Protein Services for SPN 
    GenScript Custom Purified and Recombinant Proteins Services for SPN
    Novus Biologicals SPN Proteins
    Novus Biologicals SPN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SPN

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001931uropod IEA--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA10899905
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IEA--

    SPN for ontologies           About GeneDecksing



    SPN Antibody Products: 
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    OriGene Antibodies (see all 2): SPN
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    ThermoFisher Antibody for SPN

    Assay Products for SPN: 
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    Uscn ELISAs and CLIAs for SPN

    Protein Domains /
    Families
    for SPN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P16150


    Function
    for SPN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEUK_HUMAN, P16150
    Function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical
    properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended
    rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be
    accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively
    removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in
    adaptive immune response (By similarity)

         Genatlas biochemistry entry for SPN:
    sialophorin (gpl115,leukosialin) binding ezrin pradixin/moesin (ERM) proteins

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS1683685
    GO:0005488binding ----
    GO:0005515protein binding ----
    GO:0051635bacterial cell surface binding IDA10899905
         
    SPN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SPN:
     Increased HPV18 LCR reporter a 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Spn):
     cellular  hematopoietic system  immune system  tumorigenesis 

    SPN for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Spntm1Bam for SPN
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SPN 

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): SPN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPN
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SPN (see all 11):
    hsa-miR-4288 hsa-miR-1224-3p hsa-miR-513a-3p hsa-miR-632 hsa-miR-3160-3p hsa-miR-1248 hsa-miR-877* hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPN (see all 4)
    OriGene shRNA RFP: SPN
    OriGene siRNA: SPN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPN
    Sirion Biotech Custom design and validation of potent shRNA sequences against SPN 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SPN
    Sirion Biotech Customized adenovirus for overexpression of SPN 
    Sirion Biotech Customized adenovirus for potent knockdown of SPN

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPN (see all 3)
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    GenScript: all cDNA clones in your preferred vector: SPN (NM_004158)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPN 

    Cell Line
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    Search LifeMap BioReagents cell lines for SPN
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPN


    Pathways & Interactions
    for SPN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Basigin interactions
    		Basigin interactions1.00
    2Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00
    3Cell surface interactions at the vascular wall
    		Cell surface interactions at the vascular wall1.00
    4Platelet activation, signaling and aggregation
    		Hemostasis0.43

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for SPN
        Hemostasis
    Basigin interactions
    Cell surface interactions at the vascular wall


    1         Kegg Pathway  (Kegg details for SPN):
        Cell adhesion molecules (CAMs)


    SPN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SPN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for SPN (P161503 ENSP000003532384) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS1P093823, ENSP000002159094I2D: score=4 STRING: ENSP00000215909
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    ICAM1P053623, ENSP000002648324I2D: score=2 STRING: ENSP00000264832
    SIGLEC1Q9BZZ23, ENSP000003411414I2D: score=2 STRING: ENSP00000341141
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001562response to protozoan IEA--
    GO:0001808negative regulation of type IV hypersensitivity IEA--
    GO:0006935chemotaxis TAS10753822
    GO:0006955immune response TAS2023632
    GO:0006968cellular defense response TAS1683685

    SPN for ontologies           About GeneDecksing



    Drugs & Compounds
    for SPN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SPN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SPN
    10/14 Novoseek chemical compound relationships for SPN gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polylactosamine 54.7 1 2007580 (1)
    sialic acid 48.3 9 7822786 (1), 9278308 (1), 10458318 (1), 7662987 (1) (see all 5)
    cytochalasin b 43.5 3 9224764 (2), 1358626 (1)
    fmlp 37.3 3 1358626 (2)
    pmsf 36 4 1358626 (2), 9241533 (1)
    paraffin 20 3 10360820 (2), 8037168 (1)
    polysaccharide 15.5 3 1371528 (1), 8702529 (1), 16269612 (1)
    leucine 6.2 1 18614175 (1)
    threonine 4.96 1 14552419 (1)
    tyrosine 4.56 6 14516796 (2), 8898942 (1), 9473499 (1)

    Search CenterWatch for drugs/clinical trials and news about SPN / LEUK 

    Transcripts
    for SPN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SPN gene (2 alternative transcripts): 
    NM_001030288.2  NM_003123.4  

    Unigene Cluster for SPN:

    Sialophorin
    Hs.632188  [show with all ESTs]
    Unigene Representative Sequence: NM_001030288
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395389 ENST00000436527 ENST00000563039 ENST00000360121(uc002dtm.3 uc002dtn.3)


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SPN
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate SPN (see all 11):
    hsa-miR-4288 hsa-miR-1224-3p hsa-miR-513a-3p hsa-miR-632 hsa-miR-3160-3p hsa-miR-1248 hsa-miR-877* hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPN (see all 4)
    OriGene shRNA RFP: SPN
    OriGene siRNA: SPN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPN
    Sirion Biotech Custom design and validation of potent shRNA sequences against SPN 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPN (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: SPN (NM_004158)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPN

    Additional cDNA sequence: 

    AK292626.1 AK313750.1 BC012350.1 BC035510.1 J04536.1 X60502.1 

    10 DOTS entries:

    DT.209865  DT.97792987  DT.120696486  DT.120695789  DT.100019862  DT.100804517  DT.120698081  DT.120695401 
    DT.120696423  DT.95292854 

    24/264 AceView cDNA sequences (see all 264):

    BC010033 AA421525 BU501515 CR594408 AL531128 CR595386 CR601465 BX283118 
    AA421560 CR603957 AW059610 CR600977 BU501237 CR608816 X60502 BP373131 
    BM711970 J04536 AW293885 BX104943 AA309681 BC012350 NM_014298 BC018910 

    GeneLoc Exon Structure


    Expression
    for SPN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCCCGTAAT
    SPN Expression
    About this image

    SPN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BloodPeripheral BloodB-cell Progenitor CellsBlood
    BloodPeripheral BloodPre-B CellsBlood
    BloodPeripheral BloodPro-B CellsBlood
    BoneBone MarrowHematopoietic Stem CellsBlood
    BoneBone MarrowHematopoietic Stem CellsBlood
    Lateral Plate MesodermAorta-Gonad-MesonephrosHematopoietic Stem CellsBlood
    LiverLiver BudHematopoietic Stem CellsBlood
    LiverLiver BudHematopoietic Stem CellsBlood
    BloodPeripheral BloodImmature B CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    Hematopoietic progenitor cells (Generation of hemato...)
    Enriched hematopoietic progenitors (Generation of hemato...)
    Hematopoietic progenitor cells (Generation of hemato...)
    Blast colony cells (Generation and expan...)

    See SPN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SPN

    SOURCE GeneReport for Unigene cluster: Hs.632188

    UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150
    Tissue specificity: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas

        SABiosciences Expression via Pathway-Focused PCR Array including SPN: 
              Apoptosis 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPN

    Orthologs
    for SPN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of human and mouse.

    Orthologs for SPN gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Spn1 , 5 sialophorin1, 5 64.07(n)1
    55.38(a)1    		   7 (69.35 cM)5
    207371  NM_001037810.11  NP_001032899.11 
     1271322325 


    ENSEMBL Gene Tree for SPN (if available)
    TreeFam Gene Tree for SPN (if available) 

    Paralogs
    for SPN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for SPN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/190 NCBI SNPs in SPN are shown (see all 190)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1503159171,2
    		--29672367(+) TGCCTC/TGGCCT 1 -- us2k10--------
    rs1379703131,2
    		--29672479(+) CGCCAC/TTTATA 1 -- us2k10--------
    rs80620821,2
    		C,F,A,H--29672582(+) TGTGCA/GCTTAA 2 -- us2k121Minor allele frequency- G:0.21NS EA NA WA CSA 2347
    rs1147943591,2
    		F--29672708(+) AGGAAG/ATCTGT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1910203431,2
    		--29672728(+) TTCTGC/TAGCCC 2 -- us2k10--------
    rs1423876341,2
    		--29672753(+) CTTTGC/TTCCTG 2 -- us2k10--------
    rs735283141,2
    		C--29672766(+) TCCCTC/TATCCC 2 -- us2k12Minor allele frequency- T:0.11WA 120
    rs37642751,2
    		C,F,A,H--29672982(+) AGCACA/CCCCGA 2 -- us2k120Minor allele frequency- C:0.29NS EA NA WA CSA 2342
    rs1821255451,2
    		--29673081(+) CGGTGA/CAGGCC 2 -- us2k10--------
    rs37642761,2
    		C,F,A,H--29673203(+) TCCTGT/CGGCTC 2 -- us2k132Minor allele frequency- C:0.47NS EA NA WA CSA 3201

    HapMap Linkage Disequilibrium report for SPN (29674300 - 29682187 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for SPN
         3 CNVs: 4939 35383 4000

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    Disorders / Diseases
    for SPN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SPN for disorders           About GeneDecksing

    OMIM gene information: 182160    OMIM disorders: --

    20/29 diseases for SPN (see all 29):    About MalaCards
    marginal zone b-cell lymphoma    wiskott-aldrich syndrome    b-cell lymphomas    non-hodgkin lymphoma
    richter's syndrome    adenoid cystic carcinoma    hodgkin's lymphoma    myelodysplastic syndrome
    eczema    chronic lymphocytic leukemia    lymphocytic leukemia    adenoiditis
    myeloid sarcoma    colon carcinoma    rheumatoid arthritis    atopy
    myeloid leukemia    leukemia    adenoma    sarcoma

    1 disease from the University of Copenhagen DISEASES database for SPN:
    Wiskott-Aldrich syndrome

    10/20 Novoseek disease relationships for SPN gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 79.7 14 2023632 (2), 8421057 (1), 2223062 (1), 1683685 (1) (see all 8)
    lymphoma lymphocytic 52.1 1 8037168 (1)
    colon carcinoma 35.7 4 9111064 (1), 12820726 (1), 7775421 (1), 12499775 (1)
    immunodeficiency 33.8 11 7964449 (2), 8554898 (1), 1976735 (1), 2023632 (1) (see all 7)
    eczema 27.1 2 7645397 (1)
    lymphoma t-cell 23.5 3 1976735 (1)
    adenoma 18.6 7 10360820 (3), 17891181 (1), 9299561 (1), 12499775 (1)
    myelodysplastic syndromes 17.9 2 10602163 (1), 10834507 (1)
    necrosis 8.35 3 12431190 (1), 7621589 (1), 9129210 (1)
    tumors 2.36 12 17891181 (4), 18227725 (2), 12431190 (1), 12820726 (1) (see all 7)

    Genetic Association Database (GAD): SPN
    Human Genome Epidemiology (HuGE) Navigator: SPN (4 documents)

    Export disorders for SPN gene to outside databases

    Publications
    for SPN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SPN gene, integrated from 9 sources (see all 166):
    (articles sorted by number of sources associating them with SPN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. (PubMed id 2784859)1, 2, 3 Shelley C.S.... Whitehead D.A.S. (1989)
    2. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. (PubMed id 2521952)1, 2, 3 Pallant A....Frelinger J.G. (1989)
    3. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). (PubMed id 1731338)1, 2, 9 Schmid K.... Remold-O'Donnell E. (1992)
    4. Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. (PubMed id 2241892)1, 2, 9 Shelley C.S.... Whitehead D.A.S. (1990)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. (PubMed id 1827122)1, 2 Kudo S. and Fukuda M. (1991)
    7. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. (PubMed id 17996943)1, 9 Khunkaewla P....Stockinger H. (2008)
    8. Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. (PubMed id 10753822)1, 9 Seveau S....Halbwachs-Mecarelli L. (2000)
    9. CD43 promotes cell growth and helps to evade FAS-medi ated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF. (PubMed id 17891181)1, 9 Kadaja-Saarepuu L....Maimets T. (2008)
    10. The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. (PubMed id 18586676)1, 9 Mambole A....Halbwachs-Mecarelli L. (2008)

    External Searches for SPN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    		PubMed
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    Genome Databases showing SPN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6693 HGNC: 11249 AceView: SPNandQPRT Ensembl:ENSG00000197471 euGenes: HUgn6693
    ECgene: SPN Kegg: 6693 H-InvDB: SPN

    Other Databases showing SPN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SPN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SPN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SPN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SPN gene:
    Search GeneIP for patents involving SPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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