Aliases for SPN Gene
External Ids for SPN Gene
Previous GeneCards Identifiers for SPN Gene
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]
GeneCards Summary for SPN Gene
SPN (Sialophorin) is a Protein Coding gene. Diseases associated with SPN include Mental Retardation, Autosomal Dominant 24 and Aleukemic Monocytic Leukemia Cutis. Among its related pathways are Platelet activation, signaling and aggregation and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include transmembrane signaling receptor activity.
UniProtKB/Swiss-Prot for SPN Gene
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).