Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SPN Gene

protein-coding   GIFtS: 62
GCID: GC16P029674

Sialophorin

(Previous names: sialophorin (gpL115, leukosialin, CD43))
  See SPN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Sialophorin3     GALGP2 3
sialophorin1 2     LSN2 5
CD432 3 5     GPL1152
Sialophorin (GpL115, Leukosialin, CD43)1 2     galactoglycoprotein2
leukosialin1 2     Galactoglycoprotein3
Leukocyte Sialoglycoprotein2 3     CD43 Antigen3

External Ids:    HGNC: 112491   Entrez Gene: 66932   Ensembl: ENSG000001974717   OMIM: 1821605   UniProtKB: P161503   

Export aliases for SPN gene to outside databases

Previous GC identifers: GC16M028745 GC16P029998 GC16P029672 GC16P029712 GC16P029581 GC16P027335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SPN Gene:
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes,
monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved
in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC
(antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response.
(provided by RefSeq, Sep 2011)

GeneCards Summary for SPN Gene:
SPN (sialophorin) is a protein-coding gene. Diseases associated with SPN include mental retardation, autosomal dominant 24, and myeloid sarcoma. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150
Function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical
properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an
extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains
to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is
actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory
role in adaptive immune response (By similarity)

Gene Wiki entry for SPN (CD43) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPN gene promoter:
         p53   AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPN promoter sequence
   Search Chromatin IP Primers for SPN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

SPN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPN gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029674:  view genomic region     (about GC identifiers)

Start:
29,674,300 bp from pter      End:
29,682,187 bp from pter
Size:
7,888 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150 (See protein sequence)
Recommended Name: Leukosialin precursor  
Size: 400 amino acids; 40322 Da
Subunit: Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX (By similarity)

Explore the universe of human proteins at neXtProt for SPN: NX_P16150

Explore proteomics data for SPN at MOPED

Post-translational modifications: 

  • Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures1
  • Glycosylation2 at Thr21, Thr22, Thr26, Thr28, Ser29, Ser35, Thr36, Ser37, Ser41, Ser42,
                                 Thr46, Thr47, Ser48, Thr50, Thr58, Thr69, Ser99, Ser103, Thr109, Thr113 (see all 26)
  • Modification sites at PhosphoSitePlus

  • See SPN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001025459.1  NP_003114.1  

    ENSEMBL proteins: 
     ENSP00000378787   ENSP00000412907   ENSP00000455266   ENSP00000353238  
    Reactome Protein details: P16150

    SPN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SPN
    OriGene Protein Over-expression Lysate for SPN
    OriGene MassSpec for SPN
    OriGene Custom Protein Services for SPN
    GenScript Custom Purified and Recombinant Proteins Services for SPN
    Novus Biologicals SPN Proteins
    Novus Biologicals SPN Lysates
    Sino Biological Recombinant Protein for SPN
    Sino Biological Cell Lysate for SPN
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPN

     
    Search eBioscience for Proteins for SPN 

    SPN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SPN
    R&D Systems Antibodies for SPN (CD43)
    OriGene Antibodies for SPN
    OriGene Custom Antibody Services for SPN
    Novus Biologicals SPN Antibodies
    Abcam antibodies for SPN
    Cloud-Clone Corp. Antibodies for SPN
    ThermoFisher Antibody for SPN
    LSBio Antibodies in human, mouse, rat for SPN

    SPN Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPN
    R&D Systems Proteome Profiler Antibody Arrays for SPN (CD43)
    GenScript Custom Assay Services for SPN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPN
    Cloud-Clone Corp. CLIAs for SPN
    Search eBioscience for ELISAs for SPN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules

    ProtoNet protein and cluster: P16150


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LEUK_HUMAN, P16150
    Function: One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical
    properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an
    extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains
    to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is
    actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory
    role in adaptive immune response (By similarity)

         Genatlas biochemistry entry for SPN:
    sialophorin (gpl115,leukosialin) binding ezrin pradixin/moesin (ERM) proteins

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity TAS1683685
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with SPN           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SPN:
     Increased HPV18 LCR reporter a 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Spn):
     hematopoietic system  immune system  tumorigenesis 

    Find genes that share phenotypes with SPN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Spntm1Bam for SPN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPN

    miRNA
    Products:
        
    miRTarBase miRNAs that target SPN:
    hsa-let-7e-5p (MIRT051630), hsa-let-7b-5p (MIRT052328)

    Block miRNA regulation of human, mouse, rat SPN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPN (see all 11):
    hsa-miR-4288 hsa-miR-1224-3p hsa-miR-513a-3p hsa-miR-632 hsa-miR-3160-3p hsa-miR-1248 hsa-miR-877* hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPN
    Predesigned siRNA for gene silencing in human, mouse, rat SPN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPN

    Clone
    Products:
         
    OriGene clones in human, mouse for SPN (see all 13)
    OriGene ORF clones in mouse, rat for SPN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPN (NM_004158)
    Sino Biological Human cDNA Clone for SPN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPN
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LEUK_HUMAN, P16150: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4
    golgi apparatus3
    cytoskeleton1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001931uropod IEA--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA10899905
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--

    Find genes that share ontologies with SPN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SPN About    
    See pathways by source

    SuperPathContained pathways About
    1Hemostasis
    Hemostasis0.43
    2Epstein-Barr virus infection
    Epstein-Barr virus infection
    3Cell surface interactions at the vascular wall
    Cell surface interactions at the vascular wall
    4Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    5Basigin interactions
    Basigin interactions


    Find genes that share SuperPaths with SPN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for SPN
        Basigin interactions
    Cell surface interactions at the vascular wall


    2 Kegg Pathways  (Kegg details for SPN):
        Cell adhesion molecules (CAMs)
    Epstein-Barr virus infection

        Pathway & Disease-focused RT2 Profiler PCR Array including SPN: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SPN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for SPN (P161503 ENSP000003532384) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LGALS1P093823, ENSP000002159094I2D: score=4 STRING: ENSP00000215909
    EZRP153113, ENSP000003389344I2D: score=3 STRING: ENSP00000338934
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    ICAM1P053623, ENSP000002648324I2D: score=2 STRING: ENSP00000264832
    SIGLEC1Q9BZZ23, ENSP000003411414I2D: score=2 STRING: ENSP00000341141
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001562response to protozoan IEA--
    GO:0001808negative regulation of type IV hypersensitivity IEA--
    GO:0006935chemotaxis TAS10753822
    GO:0006955immune response TAS2023632
    GO:0006968cellular defense response TAS1683685

    Find genes that share ontologies with SPN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPN (LEUK)

    Selected Novoseek inferred chemical compound relationships for SPN gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    polylactosamine 54.7 1 2007580 (1)
    sialic acid 48.3 9 7822786 (1), 9278308 (1), 10458318 (1), 7662987 (1) (see all 5)
    cytochalasin b 43.5 3 9224764 (2), 1358626 (1)
    fmlp 37.3 3 1358626 (2)
    pmsf 36 4 1358626 (2), 9241533 (1)
    paraffin 20 3 10360820 (2), 8037168 (1)
    polysaccharide 15.5 3 1371528 (1), 8702529 (1), 16269612 (1)
    leucine 6.2 1 18614175 (1)
    threonine 4.96 1 14552419 (1)
    tyrosine 4.56 6 14516796 (2), 8898942 (1), 9473499 (1)



    Find genes that share compounds with SPN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SPN gene (2 alternative transcripts): 
    NM_001030288.2  NM_003123.4  

    Unigene Cluster for SPN:

    Sialophorin
    Hs.632188  [show with all ESTs]
    Unigene Representative Sequence: NM_001030288
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395389 ENST00000436527 ENST00000563039 ENST00000561857 ENST00000360121(uc002dtm.3 uc002dtn.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SPN (see all 11):
    hsa-miR-4288 hsa-miR-1224-3p hsa-miR-513a-3p hsa-miR-632 hsa-miR-3160-3p hsa-miR-1248 hsa-miR-877* hsa-miR-3150b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPN
    Predesigned siRNA for gene silencing in human, mouse, rat SPN
    Clone
    Products:
         
    OriGene clones in human, mouse for SPN (see all 13)
    OriGene ORF clones in mouse, rat for SPN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPN (NM_004158)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SPN
    OriGene qSTAR qPCR primer pairs in human, mouse for SPN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPN
      QuantiTect SYBR Green Assays in human, mouse, rat SPN
      QuantiFast Probe-based Assays in human, mouse, rat SPN

    Additional mRNA sequence: 

    AK292626.1 AK313750.1 BC012350.1 BC035510.1 J04536.1 X60502.1 

    10 DOTS entries:

    DT.209865  DT.97792987  DT.120696486  DT.120695789  DT.120698081  DT.100019862  DT.100804517  DT.120695401 
    DT.120696423  DT.95292854 

    Selected AceView cDNA sequences (see all 264):

    BI870607 BG576832 J04536 NM_014298 BM471758 AI383718 BC010033 AA309681 
    CR603957 BC018910 CR600977 BM711970 BU501515 AA421525 BX283118 BX104943 
    AA421560 AW059610 AW293885 BP373131 CR608816 X60502 AW263079 AL531128 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SPN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCCGTAAT
    SPN Expression
    About this image


    SPN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 13 entries
             B-cell Progenitor Cells Peripheral Blood
             Hematopoietic progenitor cells
     
     Liver (Hepatobiliary System)
             Hematopoietic Stem Cells Liver Bud
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
     
     Heart (Cardiovascular System)
             Atrioventricular Node
    SPN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632188

    UniProtKB/Swiss-Prot: LEUK_HUMAN, P16150
    Tissue specificity: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas

        Pathway & Disease-focused RT2 Profiler PCR Array including SPN: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SPN
    OriGene qSTAR qPCR primer pairs in human, mouse for SPN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPN
    QuantiTect SYBR Green Assays in human, mouse, rat SPN
    QuantiFast Probe-based Assays in human, mouse, rat SPN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for SPN gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spn1 , 5 sialophorin1, 5 67.77(n)1
    60.07(a)1
      7 (69.35 cM)5
    207371  NM_001037810.11  NP_001032899.11 
     1271322325 


    ENSEMBL Gene Tree for SPN (if available)
    TreeFam Gene Tree for SPN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SPN (see all 245)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1503159171,2
    C--29672367(+) TGCCTC/TGGCCT 1 -- us2k10--------
    rs1379703131,2
    --29672479(+) CGCCAC/TTTATA 1 -- us2k10--------
    rs80620821,2
    C,F,A,H--29672582(+) tgtgcA/Gcttaa 2 -- us2k121Minor allele frequency- G:0.21NS EA NA WA CSA 2347
    rs1147943591,2
    C,F--29672708(+) AGGAAG/ATCTGT 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1910203431,2
    --29672728(+) TTCTGC/TAGCCC 2 -- us2k10--------
    rs1423876341,2
    --29672753(+) CTTTGC/TTCCTG 2 -- us2k10--------
    rs735283141,2
    C,F--29672766(+) TCCCTC/TATCCC 2 -- us2k12Minor allele frequency- T:0.11WA 120
    rs37642751,2
    C,F,A,H--29672982(+) AGCACA/CCCCGA 2 -- us2k120Minor allele frequency- C:0.29NS EA NA WA CSA 2342
    rs1821255451,2
    --29673081(+) CGGTGA/CAGGCC 2 -- us2k10--------
    rs37642761,2
    C,F,A,H--29673203(+) tcctgT/Cggctc 2 -- us2k132Minor allele frequency- C:0.47NS EA NA WA CSA 3201

    HapMap Linkage Disequilibrium report for SPN (29674300 - 29682187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SPN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833183CNV Loss17160897
    dgv34n68CNV Loss17160897
    dgv845e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPN
    DNA2.0 Custom Variant and Variant Library Synthesis for SPN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 182160    OMIM disorders: --

    6 diseases for SPN:    
    About MalaCards
    mental retardation, autosomal dominant 24    myeloid sarcoma    wiskott-aldrich syndrome    marginal zone b-cell lymphoma
    myelodysplastic syndromes    b-cell chronic lymphocytic leukemia

    1 disease from the University of Copenhagen DISEASES database for SPN:
    Wiskott-Aldrich syndrome

    Find genes that share disorders with SPN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SPN gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 79.7 14 2023632 (2), 8421057 (1), 2223062 (1), 1683685 (1) (see all 8)
    lymphoma lymphocytic 52.1 1 8037168 (1)
    colon carcinoma 35.7 4 9111064 (1), 12820726 (1), 7775421 (1), 12499775 (1)
    immunodeficiency 33.8 11 7964449 (2), 8554898 (1), 1976735 (1), 2023632 (1) (see all 7)
    eczema 27.1 2 7645397 (1)
    lymphoma t-cell 23.5 3 1976735 (1)
    adenoma 18.6 7 10360820 (3), 17891181 (1), 9299561 (1), 12499775 (1)
    myelodysplastic syndromes 17.9 2 10602163 (1), 10834507 (1)
    necrosis 8.35 3 12431190 (1), 7621589 (1), 9129210 (1)
    tumors 2.36 12 17891181 (4), 18227725 (2), 12431190 (1), 12820726 (1) (see all 7)

    Genetic Association Database (GAD): SPN
    Human Genome Epidemiology (HuGE) Navigator: SPN (4 documents)

    Export disorders for SPN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SPN gene, integrated from 10 sources (see all 171):
    (articles sorted by number of sources associating them with SPN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. (PubMed id 2784859)1, 2, 3 Shelley C.S.... Whitehead D.A.S. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    2. Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. (PubMed id 2521952)1, 2, 3 Pallant A.... Frelinger J.G. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    3. Amino acid sequence of human plasma galactoglycoprotein: identity with the extracellular region of CD43 (sialophorin). (PubMed id 1731338)1, 2, 9 Schmid K.... Remold-O'Donnell E. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    4. Structure of the human sialophorin (CD43) gene. Identification of features atypical of genes encoding integral membrane proteins. (PubMed id 2241892)1, 2, 9 Shelley C.S.... Whitehead D.A.S. (Biochem. J. 1990)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A short, novel promoter sequence confers the expression of human leukosialin, a major sialoglycoprotein on leukocytes. (PubMed id 1827122)1, 2 Kudo S. and Fukuda M. (J. Biol. Chem. 1991)
    7. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. (PubMed id 17996943)1, 9 Khunkaewla P....Stockinger H. (Mol. Immunol. 2008)
    8. Neutrophil polarity and locomotion are associated with surface redistribution of leukosialin (CD43), an antiadhesive membrane molecule. (PubMed id 10753822)1, 9 Seveau S....Halbwachs-Mecarelli L. (Blood 2000)
    9. CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF. (PubMed id 17891181)1, 9 Kadaja-Saarepuu L....Maimets T. (Oncogene 2008)
    10. The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. (PubMed id 18586676)1, 9 Mambole A....Halbwachs-Mecarelli L. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6693 HGNC: 11249 AceView: SPNandQPRT Ensembl:ENSG00000197471 euGenes: HUgn6693
    ECgene: SPN Kegg: 6693 H-InvDB: SPN

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SPN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SPN gene:
    Search GeneIP for patents involving SPN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SPN
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for SPN (CD43)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for SPN (CD43)   Proteome Profiler Antibody Arrays for SPN (CD43)  
     OriGene Antibodies for SPN   OriGene RNAi products in human, mouse, rat for SPN  
     OriGene qPCR primer pairs and template standards for SPN   OriGene Protein Over-expression Lysate for SPN  
     OriGene MassSpec something-or-other for SPN   OriGene clones in human, mouse for SPN  
     OriGene qSTAR qPCR primer pairs in human, mouse for SPN   OriGene Purified Protein for SPN  
     OriGene ORF clones in mouse, rat for SPN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SPN   OriGene Custom Protein Services for SPN  

     
     
     Block miRNA regulation of human, mouse, rat SPN using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SPN
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPN Predesigned siRNA for gene silencing in human, mouse, rat SPN
     QuantiFast Probe-based Assays in human, mouse, rat SPN QuantiTect SYBR Green Assays in human, mouse, rat SPN
     PCR Arrays including human, mouse, rat SPN Search Chromatin IP Primers for SPN
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPN  GeneGlobe Interaction Network for SPN
     Regulatory tfbs in SPN promoter
     GenScript Custom Purified and Recombinant Proteins Services for SPN GenScript cDNA clones with any tag delivered in your preferred vector for SPN
     GenScript Custom Assay Services for SPN GenScript Custom overexpressing Cell Line Services for SPN
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SPN (LEUK)
     Proteins for SPN
     Cell Lysates for SPN
     cDNA Clones for SPN
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SPN antibodies
     SPN proteins
     SPN lysates
     Antibodies for SPN
     See all of Abcam's Antibodies, Kits and Proteins for SPN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SPN
     Antibodies for SPN
     ELISAs for SPN
     CLIAs for SPN



     Browse ESI BIO Cell Lines and PureStem Progenitors for SPN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPN
     Browse SwitchGear 3'UTR luciferase reporter plasmids for SPN
     SwitchGear Promoter luciferase reporter plasmids for SPN
     ThermoFisher Antibody for SPN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPN
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPN
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPN
     LSBio Antibodies in human, mouse, rat for SPN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SPN
      Search eBioscience for proteins for SPN
      Search eBioscience for elisas for SPN
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SPN gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4