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Aliases for SPN Gene

Aliases for SPN Gene

  • Sialophorin 2 3 4 5
  • Sialophorin (GpL115, Leukosialin, CD43) 2 3
  • Leukocyte Sialoglycoprotein 3 4
  • Galactoglycoprotein 3 4
  • GALGP 3 4
  • CD43 3 4
  • CD43 Antigen 4
  • Leukosialin 2
  • GPL115 3
  • LSN 3

External Ids for SPN Gene

Previous GeneCards Identifiers for SPN Gene

  • GC16M028745
  • GC16P029998
  • GC16P029672
  • GC16P029712
  • GC16P029581
  • GC16P027335
  • GC16P029674

Summaries for SPN Gene

Entrez Gene Summary for SPN Gene

  • The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011]

GeneCards Summary for SPN Gene

SPN (Sialophorin) is a Protein Coding gene. Diseases associated with SPN include mental retardation, autosomal dominant 24 and wiskott-aldrich syndrome. Among its related pathways are Platelet activation, signaling and aggregation and Dendritic Cells Developmental Lineage Pathway. GO annotations related to this gene include transmembrane signaling receptor activity.

UniProtKB/Swiss-Prot for SPN Gene

  • One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).

Gene Wiki entry for SPN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPN Gene

Genomics for SPN Gene

Regulatory Elements for SPN Gene

Promoters for SPN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPN on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the SPN gene promoter:

Genomic Location for SPN Gene

Chromosome:
16
Start:
29,662,950 bp from pter
End:
29,670,876 bp from pter
Size:
7,927 bases
Orientation:
Plus strand

Genomic View for SPN Gene

Genes around SPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPN Gene

Proteins for SPN Gene

  • Protein details for SPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16150-LEUK_HUMAN
    Recommended name:
    Leukosialin
    Protein Accession:
    P16150
    Secondary Accessions:
    • A8K9B1

    Protein attributes for SPN Gene

    Size:
    400 amino acids
    Molecular mass:
    40322 Da
    Quaternary structure:
    • Interacts with HIPK2 via the cytoplasmic domain. Interacts with RDX (By similarity).

neXtProt entry for SPN Gene

Proteomics data for SPN Gene at MOPED

Post-translational modifications for SPN Gene

  • Glycosylated; has a high content of sialic acid and O-linked carbohydrate structures.
  • Glycosylation at Thr 21, Thr 22, Thr 26, Thr 28, Ser 29, Ser 35, Thr 36, Ser 37, Ser 41, Ser 42, Thr 46, Thr 47, Ser 48, Thr 50, Thr 58, Thr 69, Ser 99, Ser 103, Thr 109, Thr 113, Ser 114, Thr 136, Thr 137, Thr 173, Thr 178, and Asn 239
  • Modification sites at PhosphoSitePlus

Other Protein References for SPN Gene

Antibody Products

No data available for DME Specific Peptides for SPN Gene

Domains & Families for SPN Gene

Gene Families for SPN Gene

Protein Domains for SPN Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SPN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SPN: view

No data available for UniProtKB/Swiss-Prot for SPN Gene

Function for SPN Gene

Molecular function for SPN Gene

GENATLAS Biochemistry:
sialophorin (gpl115,leukosialin) binding ezrin pradixin/moesin (ERM) proteins
UniProtKB/Swiss-Prot Function:
One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response (By similarity).
genes like me logo Genes that share phenotypes with SPN: view

Animal Models for SPN Gene

MGI Knock Outs for SPN:

Animal Model Products

  • Taconic Biosciences Mouse Models for SPN

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SPN Gene

Localization for SPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPN Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPN Gene COMPARTMENTS Subcellular localization image for SPN gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
golgi apparatus 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
genes like me logo Genes that share ontologies with SPN: view

Pathways & Interactions for SPN Gene

genes like me logo Genes that share pathways with SPN: view

Gene Ontology (GO) - Biological Process for SPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001562 response to protozoan IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0006968 cellular defense response TAS 1683685
GO:0007162 negative regulation of cell adhesion IEA,TAS 10753822
GO:0007163 establishment or maintenance of cell polarity TAS 10753822
genes like me logo Genes that share ontologies with SPN: view

No data available for SIGNOR curated interactions for SPN Gene

Drugs & Compounds for SPN Gene

(9) Drugs for SPN Gene - From: Novoseek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Antibodies Pharma 4477
Autoantibodies Pharma 117
Immunoglobulins Pharma 4477

(8) Additional Compounds for SPN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SPN: view

Transcripts for SPN Gene

Unigene Clusters for SPN Gene

Sialophorin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPN Gene

No ASD Table

Relevant External Links for SPN Gene

GeneLoc Exon Structure for
SPN
ECgene alternative splicing isoforms for
SPN

Expression for SPN Gene

mRNA expression in normal human tissues for SPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPN Gene

This gene is overexpressed in Whole Blood (x10.3).

Protein differential expression in normal tissues from HIPED for SPN Gene

This gene is overexpressed in Pancreas (15.1), NK cells (10.4), Nasal epithelium (8.6), CD8 Tcells (8.0), and Neutrophil (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SPN Gene



SOURCE GeneReport for Unigene cluster for SPN Gene Hs.632188

mRNA Expression by UniProt/SwissProt for SPN Gene

P16150-LEUK_HUMAN
Tissue specificity: Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.
genes like me logo Genes that share expression patterns with SPN: view

Protein tissue co-expression partners for SPN Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SPN Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SPN 35
  • 68.52 (n)
  • 57.22 (a)
SPN 36
  • 40 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPN 35
  • 63.86 (n)
  • 46.67 (a)
SPN 36
  • 36 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spn 35
  • 67.77 (n)
  • 60.07 (a)
Spn 16
Spn 36
  • 49 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPN 35
  • 99.17 (n)
  • 98.75 (a)
SPN 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spn 35
  • 65.48 (n)
  • 59.76 (a)
oppossum
(Monodelphis domestica)
Mammalia SPN 36
  • 23 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPN 36
  • 25 (a)
OneToOne
Species with no ortholog for SPN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPN Gene

ENSEMBL:
Gene Tree for SPN (if available)
TreeFam:
Gene Tree for SPN (if available)

Paralogs for SPN Gene

No data available for Paralogs for SPN Gene

Variants for SPN Gene

Sequence variations from dbSNP and Humsavar for SPN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2229653 - 29,663,793(+) CACAA(C/T)AGCAG reference, missense
rs2229654 - 29,664,005(+) AGCCA(A/G)CAACC reference, missense
rs1050881 -- 29,664,607(+) AGAGG(C/T)GGCAA reference, synonymous-codon
rs1050882 -- 29,664,961(+) GGCCG(A/C/G)AATCT utr-variant-3-prime
rs2071420 -- 29,663,502(+) GCCTC(A/G)GGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPN Gene

Variant ID Type Subtype PubMed ID
dgv845e1 CNV Complex 17122850
nsv833183 CNV Loss 17160897
dgv34n68 CNV Loss 17160897

Variation tolerance for SPN Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.15; 51.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPN Gene

HapMap Linkage Disequilibrium report
SPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPN Gene

Disorders for SPN Gene

MalaCards: The human disease database

(13) MalaCards diseases for SPN Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal dominant 24
  • mrd24
wiskott-aldrich syndrome
  • wiskott syndrome
aleukemic monocytic leukemia cutis
adenoid basal cell carcinoma
  • skin adenoid basal cell carcinoma
multicentric papillary thyroid carcinoma
  • multicentric thyroid gland papillary carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search SPN in MalaCards View complete list of genes associated with diseases

Relevant External Links for SPN

Genetic Association Database (GAD)
SPN
Human Genome Epidemiology (HuGE) Navigator
SPN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPN
genes like me logo Genes that share disorders with SPN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SPN Gene

Publications for SPN Gene

  1. Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome. (PMID: 2784859) Shelley C.S. … Whitehead D.A.S. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3 4 67
  2. CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in non-hematopoietic cancer cells lacking the tumor suppressors p53 or ARF. (PMID: 17891181) Kadaja-Saarepuu L. … Maimets T. (Oncogene 2008) 3 23
  3. LFA-1-mediated leukocyte adhesion regulated by interaction of CD43 with LFA-1 and CD147. (PMID: 17996943) Khunkaewla P. … Stockinger H. (Mol. Immunol. 2008) 3 23
  4. The selective expression of CD43 in adenoid cystic carcinoma. (PMID: 18227725) Seethala R.R. … Zhang P.J. (Appl. Immunohistochem. Mol. Morphol. 2008) 3 23
  5. The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase. (PMID: 18586676) Mambole A. … Halbwachs-Mecarelli L. (J. Biol. Chem. 2008) 3 23

Products for SPN Gene

Sources for SPN Gene

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