Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SPIRE2 Gene

Aliases for SPIRE2 Gene

  • Spire Type Actin Nucleation Factor 2 2 3 5
  • Spire Family Actin Nucleation Factor 2 2 3
  • Spir-2 3 4
  • Spire-Type Actin Nucleation Factor 2 2
  • Spire Actin Nucleation Factor 2 3
  • Spire Homolog 2 (Drosophila) 2
  • Protein Spire Homolog 2 3
  • Spire Homolog 2 3
  • KIAA1832 4
  • SPIR2 4

External Ids for SPIRE2 Gene

Previous GeneCards Identifiers for SPIRE2 Gene

  • GC16P089639
  • GC16P088421
  • GC16P089894
  • GC16P075589

Summaries for SPIRE2 Gene

GeneCards Summary for SPIRE2 Gene

SPIRE2 (Spire Type Actin Nucleation Factor 2) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway. GO annotations related to this gene include actin binding. An important paralog of this gene is SPIRE1.

UniProtKB/Swiss-Prot for SPIRE2 Gene

  • Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.

Additional gene information for SPIRE2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIRE2 Gene

Genomics for SPIRE2 Gene

Regulatory Elements for SPIRE2 Gene

Enhancers for SPIRE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H089815 1.6 Ensembl ENCODE dbSUPER 55.2 +0.0 44 4 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 SPIRE2 CDK10 ANKRD11 ENSG00000259006 RNU6-430P ENSG00000261692 AFG3L1P MC1R ENSG00000268218 TCF25
GH16H089832 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18.8 +18.3 18322 6 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 BRCA1 YY1 ZNF121 SLC30A9 CDK10 SPIRE2 TUBB3 VPS9D1 ZNF276 FANCA RPL13 ACSF3 MC1R LOC105371419
GH16H089825 1.6 FANTOM5 ENCODE dbSUPER 18 +10.8 10832 5 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 CDK10 FANCA SPIRE2 AFG3L1P SPG7 MC1R ZNF778 ENSG00000268218 ENSG00000260279 LOC101927863
GH16H089842 1.4 Ensembl ENCODE dbSUPER 17.8 +25.6 25626 1 NFIB SIN3A RFX5 ZNF121 GLIS2 GATA2 EGR1 ZNF366 FOS RCOR1 SPATA2L SPIRE2 CDK10 FANCA VPS9D1 ZNF276 LOC105371419
GH16H089862 1.3 Ensembl ENCODE dbSUPER 17.3 +46.8 46753 2 BCOR PKNOX1 TBL1XR1 SIN3A ZMYM3 RELA YY1 MTA3 POLR2A EED CDK10 SPIRE2 TUBB3 LOC105371419 TCF25
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SPIRE2 on UCSC Golden Path with GeneCards custom track

Promoters for SPIRE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000089780 -977 2201 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 FOS

Genomic Location for SPIRE2 Gene

Chromosome:
16
Start:
89,817,477 bp from pter
End:
89,871,319 bp from pter
Size:
53,843 bases
Orientation:
Plus strand

Genomic View for SPIRE2 Gene

Genes around SPIRE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIRE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIRE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIRE2 Gene

Proteins for SPIRE2 Gene

  • Protein details for SPIRE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWL2-SPIR2_HUMAN
    Recommended name:
    Protein spire homolog 2
    Protein Accession:
    Q8WWL2
    Secondary Accessions:
    • A4QPB1
    • Q2TA98
    • Q6P433
    • Q8ND47
    • Q96JJ5

    Protein attributes for SPIRE2 Gene

    Size:
    714 amino acids
    Molecular mass:
    79671 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47461.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD19439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SPIRE2 Gene

    Alternative splice isoforms for SPIRE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPIRE2 Gene

Post-translational modifications for SPIRE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SPIRE2 Gene

Domains & Families for SPIRE2 Gene

Gene Families for SPIRE2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for SPIRE2 Gene

Suggested Antigen Peptide Sequences for SPIRE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWL2

UniProtKB/Swiss-Prot:

SPIR2_HUMAN :
  • Binds to actin monomers via the WH2 domain.
  • Belongs to the spire family.
Domain:
  • Binds to actin monomers via the WH2 domain.
  • The Spir-box targets binding to intracellular membrane structures.
Family:
  • Belongs to the spire family.
genes like me logo Genes that share domains with SPIRE2: view

Function for SPIRE2 Gene

Molecular function for SPIRE2 Gene

UniProtKB/Swiss-Prot Function:
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.

Phenotypes From GWAS Catalog for SPIRE2 Gene

Gene Ontology (GO) - Molecular Function for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with SPIRE2: view

Phenotypes for SPIRE2 Gene

GenomeRNAi human phenotypes for SPIRE2:
genes like me logo Genes that share phenotypes with SPIRE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPIRE2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIRE2 Gene

Localization for SPIRE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIRE2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SPIRE2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex IEA,ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

Pathways & Interactions for SPIRE2 Gene

SuperPathways for SPIRE2 Gene

SuperPathway Contained pathways
1 TGF-Beta Pathway
genes like me logo Genes that share pathways with SPIRE2: view

Pathways by source for SPIRE2 Gene

1 Qiagen pathway for SPIRE2 Gene

Gene Ontology (GO) - Biological Process for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport ISS,IEA --
GO:0030036 actin cytoskeleton organization IEA,IMP 21620703
GO:0036089 cleavage furrow formation IEA,ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

No data available for SIGNOR curated interactions for SPIRE2 Gene

Drugs & Compounds for SPIRE2 Gene

(1) Drugs for SPIRE2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LATRUNCULIN B Experimental Pharma Target 0
genes like me logo Genes that share compounds with SPIRE2: view

Transcripts for SPIRE2 Gene

Unigene Clusters for SPIRE2 Gene

Spire homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SPIRE2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SPIRE2 Gene

No ASD Table

Relevant External Links for SPIRE2 Gene

GeneLoc Exon Structure for
SPIRE2
ECgene alternative splicing isoforms for
SPIRE2

Expression for SPIRE2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SPIRE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPIRE2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3), Pituitary (x4.3), Colon - Transverse (x4.2), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for SPIRE2 Gene

This gene is overexpressed in Heart (47.7) and Placenta (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPIRE2 Gene



Protein tissue co-expression partners for SPIRE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIRE2 Gene:

SPIRE2

SOURCE GeneReport for Unigene cluster for SPIRE2 Gene:

Hs.461786

Evidence on tissue expression from TISSUES for SPIRE2 Gene

  • Nervous system(4.2)
  • Skin(4)
genes like me logo Genes that share expression patterns with SPIRE2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SPIRE2 Gene

Orthologs for SPIRE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPIRE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIRE2 33 34
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia SPIRE2 33 34
  • 84.85 (n)
mouse
(Mus musculus)
Mammalia Spire2 33 16 34
  • 83.86 (n)
rat
(Rattus norvegicus)
Mammalia Spire2 33
  • 83.82 (n)
cow
(Bos Taurus)
Mammalia SPIRE2 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPIRE2 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPIRE2 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPIRE2 33 34
  • 74.23 (n)
lizard
(Anolis carolinensis)
Reptilia SPIRE2 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spire2 33
  • 62.75 (n)
Str.1771 33
zebrafish
(Danio rerio)
Actinopterygii spire2 33 34
  • 63.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008101 33
  • 60.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta spir 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8252 34
  • 26 (a)
OneToMany
Species where no ortholog for SPIRE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIRE2 Gene

ENSEMBL:
Gene Tree for SPIRE2 (if available)
TreeFam:
Gene Tree for SPIRE2 (if available)

Paralogs for SPIRE2 Gene

Paralogs for SPIRE2 Gene

(1) SIMAP similar genes for SPIRE2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPIRE2: view

Variants for SPIRE2 Gene

Sequence variations from dbSNP and Humsavar for SPIRE2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs773159223 Pathogenic 89,815,912(+) GCTTC(A/G)CAGGA nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs786204238 Pathogenic 89,815,969(-) AGAGG(-/G)AAAAA nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs115856189 Likely benign 89,816,595(+) GAGTT(A/C/T)GGGAC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon
rs1800282 Likely benign 89,816,599(-) GTGGG(A/T)CCCGA nc-transcript-variant, upstream-variant-2KB, reference, missense
rs189841793 Likely benign 89,815,999(+) GAGAA(A/G)TCGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SPIRE2 Gene

Variant ID Type Subtype PubMed ID
dgv1389n106 CNV deletion 24896259
dgv5324n54 CNV loss 21841781
dgv5325n54 CNV loss 21841781
dgv5326n54 CNV loss 21841781
dgv5327n54 CNV loss 21841781
dgv5328n54 CNV loss 21841781
dgv5329n54 CNV loss 21841781
dgv5330n54 CNV loss 21841781
dgv5331n54 CNV loss 21841781
dgv5332n54 CNV loss 21841781
dgv5333n54 CNV gain+loss 21841781
dgv5334n54 CNV loss 21841781
dgv5335n54 CNV loss 21841781
dgv63e180 CNV loss 20482838
esv1005255 CNV deletion 20482838
esv1071043 CNV insertion 17803354
esv23219 CNV gain+loss 19812545
esv2501942 CNV insertion 19546169
esv2657578 CNV deletion 23128226
esv2663404 CNV deletion 23128226
esv2668309 CNV deletion 23128226
esv2758671 CNV loss 17122850
esv2762221 CNV gain+loss 21179565
esv29066 CNV loss 19812545
esv3180457 CNV deletion 24192839
esv32652 CNV loss 17666407
esv3385098 CNV duplication 20981092
esv3553914 CNV deletion 23714750
esv3553915 CNV deletion 23714750
esv3639600 CNV loss 21293372
esv3639601 CNV loss 21293372
esv993879 CNV deletion 20482838
nsv1059577 CNV loss 25217958
nsv1070370 CNV deletion 25765185
nsv1071317 CNV deletion 25765185
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv457624 CNV loss 19166990
nsv482951 CNV loss 15286789
nsv573743 CNV gain 21841781
nsv573744 CNV loss 21841781
nsv573770 CNV loss 21841781
nsv573791 CNV loss 21841781
nsv573798 CNV gain+loss 21841781
nsv573799 CNV gain 21841781
nsv573810 CNV loss 21841781
nsv833331 CNV gain+loss 17160897
nsv9478 CNV loss 18304495

Variation tolerance for SPIRE2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPIRE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPIRE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIRE2 Gene

Disorders for SPIRE2 Gene

Relevant External Links for SPIRE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPIRE2

No disorders were found for SPIRE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIRE2 Gene

Publications for SPIRE2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  2. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. (PMID: 21620703) Pfender S … Schuh M (Current biology : CB 2011) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. (PMID: 27627128) Andritschke D … Hardt WD (PloS one 2016) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for SPIRE2 Gene

Sources for SPIRE2 Gene

Content
Loading form....