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SPIRE2 Gene

protein-coding   GIFtS: 49
GCID: GC16P089894

Spire-Type Actin Nucleation Factor 2

(Previous names: spire homolog 2 (Drosophila), spire family actin nucleation...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Spire-Type Actin Nucleation Factor 21 2     Spire Actin Nucleation Factor 22
Spire Family Actin Nucleation Factor 21 2     Spire Homolog 22
Spir-22 3     KIAA18323
Spire Homolog 2 (Drosophila)1     SPIR23
Protein Spire Homolog 22     

External Ids:    HGNC: 306231   Entrez Gene: 845012   Ensembl: ENSG000002049917   OMIM: 6092175   UniProtKB: Q8WWL23   

Export aliases for SPIRE2 gene to outside databases

Previous GC identifers: GC16P089639 GC16P088421 GC16P075589


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SPIRE2 Gene:
SPIRE2 (spire-type actin nucleation factor 2) is a protein-coding gene. Diseases associated with SPIRE2 include malaria, and thyroiditis. GO annotations related to this gene include actin binding. An important paralog of this gene is SPIRE1.

UniProtKB/Swiss-Prot: SPIR2_HUMAN, Q8WWL2
Function: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new
filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin
cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric
cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion
during female germ cell meiosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SPIRE2 gene promoter:
         Elk-1   GATA-3   Olf-1   LCR-F1   AP-2gamma   POU2F1   COMP1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSPIRE2 promoter sequence
   Search Chromatin IP Primers for SPIRE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SPIRE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24

SPIRE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPIRE2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P089894:  view genomic region     (about GC identifiers)

Start:
89,884,587 bp from pter      End:
89,937,727 bp from pter
Size:
53,141 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SPIR2_HUMAN, Q8WWL2 (See protein sequence)
Recommended Name: Protein spire homolog 2  
Size: 714 amino acids; 79671 Da
Sequence caution: Sequence=BAB47461.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD19439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4QPB1 Q2TA98 Q6P433 Q8ND47 Q96JJ5
Alternative splicing: 4 isoforms:  Q8WWL2-1   Q8WWL2-2   Q8WWL2-3   Q8WWL2-4   

Explore the universe of human proteins at neXtProt for SPIRE2: NX_Q8WWL2

Explore proteomics data for SPIRE2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SPIRE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115827.1  
    ENSEMBL proteins: 
     ENSP00000376782   ENSP00000367494   ENSP00000457940   ENSP00000457981  

    SPIRE2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein for SPIRE2
    OriGene Protein Over-expression Lysate for SPIRE2
    OriGene MassSpec for SPIRE2
    OriGene Custom Protein Services for SPIRE2
    GenScript Custom Purified and Recombinant Proteins Services for SPIRE2
    Novus Biologicals SPIRE2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SPIRE2

    SPIRE2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SPIRE2
    Novus Biologicals SPIRE2 Antibodies
    Abcam antibodies for SPIRE2
    Cloud-Clone Corp. Antibodies for SPIRE2
    ThermoFisher Antibodies for SPIRE2
    LSBio Antibodies in human, mouse, rat for SPIRE2

    SPIRE2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SPIRE2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SPIRE2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SPIRE2
    Cloud-Clone Corp. CLIAs for SPIRE2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR003124 WH2_dom
     IPR011019 KIND
     IPR013083 Znf_RING/FYVE/PHD
     IPR011011 Znf_FYVE_PHD

    Graphical View of Domain Structure for InterPro Entry Q8WWL2

    ProtoNet protein and cluster: Q8WWL2

    1 Blocks protein domain: IPB003124 Actin-binding WH2

    UniProtKB/Swiss-Prot: SPIR2_HUMAN, Q8WWL2
    Domain: Binds to actin monomers via the WH2 domain (By similarity)
    Domain: The Spir-box targets binding to intracellular membrane structures (By similarity)
    Similarity: Belongs to the spire family
    Similarity: Contains 1 KIND domain
    Similarity: Contains 3 WH2 domains


    SPIRE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SPIR2_HUMAN, Q8WWL2
    Function: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new
    filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin
    cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric
    cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion
    during female germ cell meiosis

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
         
    SPIRE2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SPIRE2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SPIRE2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SPIRE2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SPIRE2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat SPIRE2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SPIRE2:
    hsa-miR-4324 hsa-miR-544b hsa-miR-656 hsa-miR-493* hsa-miR-3924 hsa-miR-1295
    SwitchGear 3'UTR luciferase reporter plasmidSPIRE2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SPIRE2
    Predesigned siRNA for gene silencing in human, mouse, rat SPIRE2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SPIRE2

    Clone
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    OriGene clones in human, mouse for SPIRE2 (see all 6)
    OriGene ORF clones in mouse, rat for SPIRE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPIRE2 (NM_032451)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIRE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIRE2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SPIRE2
    Browse ESI BIO Cell Lines and PureStem Progenitors for SPIRE2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIRE2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SPIR2_HUMAN, Q8WWL2: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasm,
    perinuclear region (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
    Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Detected at the
    cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus3
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005938cell cortex ISS--
    GO:0030659cytoplasmic vesicle membrane ISS--

    SPIRE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SPIRE2 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-Beta Pathway
    JNK Pathway0.51
    2Dorso-ventral axis formation
    Dorso-ventral axis formation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SPIRE2
        JNK Pathway


    1 Kegg Pathway  (Kegg details for SPIRE2):
        Dorso-ventral axis formation


    SPIRE2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SPIRE2
    Interactions:

        Search GeneGlobe Interaction Network for SPIRE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SPIRE2 (ENSP000003674944) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTL6AENSP000003975524STRING: ENSP00000397552
    ACTL6BENSP000001603824STRING: ENSP00000160382
    NANOS1ENSP000003932754STRING: ENSP00000393275
    ACTA1ENSP000003556454STRING: ENSP00000355645
    ACTA2ENSP000002247844STRING: ENSP00000224784
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016192vesicle-mediated transport ISS--
    GO:0030036actin cytoskeleton organization IMP--
    GO:0036089cleavage furrow formation ISS--
    GO:0040038polar body extrusion after meiotic divisions ISS--

    SPIRE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SPIRE2 (SPIR2)

    1 DrugBank Compound for SPIRE2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LATRUNCULIN B-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SPIRE2 gene: 
    NM_032451.1  

    Unigene Cluster for SPIRE2:

    Spire homolog 2 (Drosophila)
    Hs.461786  [show with all ESTs]
    Unigene Representative Sequence: NM_032451
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564878 ENST00000565103 ENST00000393062(uc010civ.1) ENST00000378247(uc002foz.1 uc010ciw.1 uc002fpa.1 uc010cix.1)
    ENST00000563972 ENST00000566337 ENST00000569108 ENST00000561883 ENST00000562029
    ENST00000565628
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SPIRE2 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate SPIRE2:
    hsa-miR-4324 hsa-miR-544b hsa-miR-656 hsa-miR-493* hsa-miR-3924 hsa-miR-1295
    SwitchGear 3'UTR luciferase reporter plasmidSPIRE2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SPIRE2
    Predesigned siRNA for gene silencing in human, mouse, rat SPIRE2
    Clone
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    OriGene clones in human, mouse for SPIRE2 (see all 6)
    OriGene ORF clones in mouse, rat for SPIRE2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SPIRE2 (NM_032451)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SPIRE2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SPIRE2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SPIRE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPIRE2
      QuantiTect SYBR Green Assays in human, mouse, rat SPIRE2
      QuantiFast Probe-based Assays in human, mouse, rat SPIRE2

    Additional mRNA sequence: 

    AB058735.1 AJ422077.1 AK094918.1 AK098674.1 AK130680.1 AK130685.1 AL834408.1 BC011119.1 
    BC035173.1 BC063706.1 BC111030.1 BC139732.1 

    8 DOTS entries:

    DT.431896  DT.99927663  DT.95313239  DT.92050594  DT.100777444  DT.102828536  DT.91857928  DT.97805022 

    Selected AceView cDNA sequences (see all 68):

    BC035669 AI885688 BM557869 BC063706 BE018027 AL834408 BF988903 AL541809 
    BC011119 AA345427 AB058735 CR593729 AW294165 AA553722 BQ084433 BE885160 
    BI005758 R06103 AA180430 BG697287 BQ083696 BI913589 BX431410 AK130685 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SPIRE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SPIRE2 Expression
    About this image


    SPIRE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Left Ventricle
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Thyroid (Endocrine System)
    SPIRE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SPIRE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.461786
        Custom PCR Arrays for SPIRE2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SPIRE2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SPIRE2
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    QuantiFast Probe-based Assays in human, mouse, rat SPIRE2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPIRE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SPIRE2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Spire21 , 5 spire homolog 2 (Drosophila)1, 5 83.86(n)1
    86.85(a)1
      8 (72.10 cM)5
    2348571  NM_172287.21  NP_758491.11 
     1233327135 
    chicken
    (Gallus gallus)
    Aves SPIRE21 spire homolog 2 (Drosophila) 74.23(n)
    73.11(a)
      415855  XM_004944322.1  XP_004944379.1 
    lizard
    (Anolis carolinensis)
    Reptilia SPIRE26
    spire-type actin nucleation factor 2
    58(a)
    1 ↔ 1
    GL343866.1(28-14075)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.17712 Transcribed sequences 73.17(n)    141997724 
    zebrafish
    (Danio rerio)
    Actinopterygii spire21 spire homolog 2 (Drosophila) 63.61(n)
    61.05(a)
      492470  NM_001007342.1  NP_001007343.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spir6
    spire
    19(a)
    1 → many
    2L(20311219-20348386)


    ENSEMBL Gene Tree for SPIRE2 (if available)
    TreeFam Gene Tree for SPIRE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SPIRE2 gene
    SPIRE12  
    1 SIMAP similar gene for SPIRE2 using alignment to 3 protein entries:     SPIR2_HUMAN (see all proteins):
    SPIRE1

    SPIRE2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SPIRE2 (see all 1330)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900860861,2
    --75587133(+) AATTCC/GCCATC 1 -- int10--------
    rs1822559251,2
    --75587182(+) TACCAC/TGAATG 1 -- int10--------
    rs1864665821,2
    --75587196(+) AGCGTA/GCTGCT 1 -- int10--------
    rs1119551221,2
    C--75587255(+) AAGCCA/GGAACT 1 -- int12Minor allele frequency- G:0.03CSA WA 120
    rs1896699811,2
    --75587319(+) AATCAA/GGAGGG 1 -- int10--------
    rs1822882751,2
    --75587338(+) CTTGAC/GTGCCA 1 -- int10--------
    rs47857231,2
    C,F,A,H--75587428(+) ACTGCA/GCCTAT 1 -- int122Minor allele frequency- G:0.36NS EA NA WA CSA 2349
    rs1455239281,2
    C--75587445(+) TTATGA/CATCTA 1 -- int10--------
    rs1854454331,2
    --75587551(+) TCCTGA/CCTTAC 1 -- int10--------
    rs743323021,2
    C,F--75587603(+) TGGCTA/GATGTT 1 -- int13Minor allele frequency- G:0.05WA CSA 121

    HapMap Linkage Disequilibrium report for SPIRE2 (89884587 - 89937727 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SPIRE2 (see all 25):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2663404CNV Deletion23128226
    esv2668309CNV Deletion23128226
    esv2657578CNV Deletion23128226
    esv1005255CNV Deletion20482838
    esv993879CNV Deletion20482838
    esv1071043CNV Insertion17803354
    esv2501942CNV Insertion19546169
    dgv3009n71CNV Loss21882294
    nsv907433CNV Loss21882294
    nsv907441CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SPIRE2
    DNA2.0 Custom Variant and Variant Library Synthesis for SPIRE2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609217    OMIM disorders: --

    2 diseases for SPIRE2:    
    About MalaCards
    malaria    thyroiditis


    SPIRE2 for disorders           About GeneDecksing


    Export disorders for SPIRE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SPIRE2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SPIRE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. (PubMed id 21620703)2 Pfender S.... Schuh M. (Curr. Biol. 2011)
    3. Identification of a short Spir interaction sequence at the C-terminal end of formin subgroup proteins. (PubMed id 19605360)1 Pechlivanis M....Kerkhoff E. (J. Biol. Chem. 2009)
    4. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    5. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84501 HGNC: 30623 AceView: SPIRE2 Ensembl:ENSG00000204991 euGenes: HUgn84501
    ECgene: SPIRE2 Kegg: 84501 H-InvDB: SPIRE2

    (According to HUGE)
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    HUGE: KIAA1832

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SPIRE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SPIRE2 gene:
    Search GeneIP for patents involving SPIRE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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