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Aliases for SPIRE2 Gene

Aliases for SPIRE2 Gene

  • Spire-Type Actin Nucleation Factor 2 2 3
  • Spire Family Actin Nucleation Factor 2 2 3
  • Spir-2 3 4
  • Spire Actin Nucleation Factor 2 3
  • Spire Homolog 2 (Drosophila) 2
  • Protein Spire Homolog 2 3
  • Spire Homolog 2 3
  • KIAA1832 4
  • SPIR2 4

External Ids for SPIRE2 Gene

Previous GeneCards Identifiers for SPIRE2 Gene

  • GC16P089639
  • GC16P088421
  • GC16P089894
  • GC16P075589

Summaries for SPIRE2 Gene

GeneCards Summary for SPIRE2 Gene

SPIRE2 (Spire-Type Actin Nucleation Factor 2) is a Protein Coding gene. Among its related pathways are TGF-Beta Pathway and Dorso-ventral axis formation. GO annotations related to this gene include actin binding. An important paralog of this gene is SPIRE1.

UniProtKB/Swiss-Prot for SPIRE2 Gene

  • Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIRE2 Gene

Genomics for SPIRE2 Gene

Regulatory Elements for SPIRE2 Gene

Genomic Location for SPIRE2 Gene

Start:
89,818,179 bp from pter
End:
89,871,319 bp from pter
Size:
53,141 bases
Orientation:
Plus strand

Genomic View for SPIRE2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPIRE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIRE2 Gene

Proteins for SPIRE2 Gene

  • Protein details for SPIRE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWL2-SPIR2_HUMAN
    Recommended name:
    Protein spire homolog 2
    Protein Accession:
    Q8WWL2
    Secondary Accessions:
    • A4QPB1
    • Q2TA98
    • Q6P433
    • Q8ND47
    • Q96JJ5

    Protein attributes for SPIRE2 Gene

    Size:
    714 amino acids
    Molecular mass:
    79671 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47461.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD19439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPIRE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPIRE2 Gene

Proteomics data for SPIRE2 Gene at MOPED

Post-translational modifications for SPIRE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPIRE2 Gene

No data available for DME Specific Peptides for SPIRE2 Gene

Domains for SPIRE2 Gene

Protein Domains for SPIRE2 Gene

Suggested Antigen Peptide Sequences for SPIRE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWL2

UniProtKB/Swiss-Prot:

SPIR2_HUMAN :
  • Q8WWL2
Domain:
  • Binds to actin monomers via the WH2 domain.
  • The Spir-box targets binding to intracellular membrane structures.
  • Contains 1 KIND domain.
  • Contains 3 WH2 domains.
Family:
  • Belongs to the spire family.
genes like me logo Genes that share domains with SPIRE2: view

No data available for Gene Families for SPIRE2 Gene

Function for SPIRE2 Gene

Molecular function for SPIRE2 Gene

UniProtKB/Swiss-Prot Function: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.

Gene Ontology (GO) - Molecular Function for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with SPIRE2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SPIRE2 Gene

Localization for SPIRE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIRE2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIRE2 Gene COMPARTMENTS Subcellular localization image for SPIRE2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex ISS --
GO:0030659 cytoplasmic vesicle membrane ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

Pathways for SPIRE2 Gene

genes like me logo Genes that share pathways with SPIRE2: view

Pathways by source for SPIRE2 Gene

1 Qiagen pathway for SPIRE2 Gene
1 KEGG pathway for SPIRE2 Gene

Interacting Proteins for SPIRE2 Gene

Gene Ontology (GO) - Biological Process for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport ISS --
GO:0030036 actin cytoskeleton organization IMP 21620703
GO:0036089 cleavage furrow formation ISS --
GO:0040038 polar body extrusion after meiotic divisions ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

Compounds for SPIRE2 Gene

(1) Drugbank Compounds for SPIRE2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
LATRUNCULIN B
target
genes like me logo Genes that share compounds with SPIRE2: view

Transcripts for SPIRE2 Gene

Unigene Clusters for SPIRE2 Gene

Spire homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPIRE2 Gene

No ASD Table

Relevant External Links for SPIRE2 Gene

GeneLoc Exon Structure for
SPIRE2
ECgene alternative splicing isoforms for
SPIRE2

Expression for SPIRE2 Gene

mRNA expression in normal human tissues for SPIRE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPIRE2 Gene

This gene is overexpressed in Brain - Cerebellum (4.3), Pituitary (4.3), Colon - Transverse (4.2), and Brain - Cerebellar Hemisphere (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SPIRE2 Gene

SOURCE GeneReport for Unigene cluster for SPIRE2 Gene Hs.461786

genes like me logo Genes that share expressions with SPIRE2: view

No data available for mRNA Expression by UniProt/SwissProt for SPIRE2 Gene

Orthologs for SPIRE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPIRE2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SPIRE2 35
  • 99.01 (n)
  • 98.51 (a)
SPIRE2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SPIRE2 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SPIRE2 35
  • 84.85 (n)
  • 85.57 (a)
SPIRE2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spire2 35
  • 83.86 (n)
  • 86.85 (a)
Spire2 16
Spire2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPIRE2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPIRE2 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spire2 35
  • 83.82 (n)
  • 86.99 (a)
chicken
(Gallus gallus)
Aves SPIRE2 35
  • 74.23 (n)
  • 73.11 (a)
SPIRE2 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPIRE2 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spire2 35
  • 62.75 (n)
  • 62.95 (a)
Str.1771 35
zebrafish
(Danio rerio)
Actinopterygii spire2 35
  • 63.61 (n)
  • 61.05 (a)
spire2 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008101 35
  • 60.11 (n)
  • 49.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta spir 36
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8252 36
  • 26 (a)
OneToMany
Species with no ortholog for SPIRE2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIRE2 Gene

ENSEMBL:
Gene Tree for SPIRE2 (if available)
TreeFam:
Gene Tree for SPIRE2 (if available)

Paralogs for SPIRE2 Gene

Paralogs for SPIRE2 Gene

Selected SIMAP similar genes for SPIRE2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPIRE2: view

Variants for SPIRE2 Gene

Sequence variations from dbSNP and Humsavar for SPIRE2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1079555 -- 89,828,637(-) TAGGC(A/C)TTCAG reference, missense
rs1079556 -- 89,828,630(-) TCAGC(A/T)CCTCC missense, reference
rs1079557 -- 89,828,593(-) CCGCC(C/T)TGCGC missense, reference
rs1079558 -- 89,841,595(-) CTTAC(C/T)CAAGA intron-variant
rs1105691 -- 89,856,077(-) GAAGC(A/G)GGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPIRE2 Gene

Variant ID Type Subtype PubMed ID
nsv428331 CNV Gain+Loss 18775914
dgv3009n71 CNV Loss 21882294
nsv457623 CNV Gain 19166990
nsv907429 CNV Loss 21882294
nsv833331 CNV Gain+Loss 17160897
nsv457624 CNV Loss 19166990
nsv907432 CNV Loss 21882294
nsv907433 CNV Loss 21882294
dgv923e1 CNV Complex 17122850
dgv3013n71 CNV Loss 21882294
dgv3014n71 CNV Loss 21882294
dgv3015n71 CNV Loss 21882294
esv993879 CNV Deletion 20482838
nsv9478 CNV Loss 18304495
esv1005255 CNV Deletion 20482838
esv2668309 CNV Deletion 23128226
esv29066 CNV Loss 19812545
dgv63e180 CNV Loss 20482838
esv32652 CNV Loss 17666407
esv2657578 CNV Deletion 23128226
esv2501942 CNV Insertion 19546169
nsv907441 CNV Loss 21882294
esv1071043 CNV Insertion 17803354
esv2663404 CNV Deletion 23128226
esv23219 CNV Gain+Loss 19812545

Relevant External Links for SPIRE2 Gene

HapMap Linkage Disequilibrium report
SPIRE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIRE2 Gene

Disorders for SPIRE2 Gene

No disorders were found for SPIRE2 Gene.

No data available for UniProtKB/Swiss-Prot for SPIRE2 Gene

Publications for SPIRE2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  2. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. (PMID: 21620703) Pfender S. … Schuh M. (Curr. Biol. 2011) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4

Products for SPIRE2 Gene

Sources for SPIRE2 Gene

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