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Aliases for SPIRE2 Gene

Aliases for SPIRE2 Gene

  • Spire Type Actin Nucleation Factor 2 2 3 5
  • Spire Family Actin Nucleation Factor 2 2 3
  • Spir-2 3 4
  • Spire-Type Actin Nucleation Factor 2 2
  • Spire Actin Nucleation Factor 2 3
  • Spire Homolog 2 (Drosophila) 2
  • Protein Spire Homolog 2 3
  • Spire Homolog 2 3
  • KIAA1832 4
  • SPIR2 4

External Ids for SPIRE2 Gene

Previous GeneCards Identifiers for SPIRE2 Gene

  • GC16P089639
  • GC16P088421
  • GC16P089894
  • GC16P075589

Summaries for SPIRE2 Gene

GeneCards Summary for SPIRE2 Gene

SPIRE2 (Spire Type Actin Nucleation Factor 2) is a Protein Coding gene. Among its related pathways are Dorso-ventral axis formation and TGF-Beta Pathway. GO annotations related to this gene include actin binding. An important paralog of this gene is SPIRE1.

UniProtKB/Swiss-Prot for SPIRE2 Gene

  • Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPIRE2 Gene

Genomics for SPIRE2 Gene

Regulatory Elements for SPIRE2 Gene

Enhancers for SPIRE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SPIRE2 on UCSC Golden Path with GeneCards custom track

Promoters for SPIRE2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SPIRE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPIRE2 Gene

Chromosome:
16
Start:
89,817,477 bp from pter
End:
89,871,319 bp from pter
Size:
53,843 bases
Orientation:
Plus strand

Genomic View for SPIRE2 Gene

Genes around SPIRE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPIRE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPIRE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPIRE2 Gene

Proteins for SPIRE2 Gene

  • Protein details for SPIRE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWL2-SPIR2_HUMAN
    Recommended name:
    Protein spire homolog 2
    Protein Accession:
    Q8WWL2
    Secondary Accessions:
    • A4QPB1
    • Q2TA98
    • Q6P433
    • Q8ND47
    • Q96JJ5

    Protein attributes for SPIRE2 Gene

    Size:
    714 amino acids
    Molecular mass:
    79671 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47461.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD19439.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for SPIRE2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SPIRE2 Gene

Post-translational modifications for SPIRE2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPIRE2 Gene

No data available for DME Specific Peptides for SPIRE2 Gene

Domains & Families for SPIRE2 Gene

Protein Domains for SPIRE2 Gene

Suggested Antigen Peptide Sequences for SPIRE2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WWL2

UniProtKB/Swiss-Prot:

SPIR2_HUMAN :
  • Binds to actin monomers via the WH2 domain.
  • Belongs to the spire family.
Domain:
  • Binds to actin monomers via the WH2 domain.
  • The Spir-box targets binding to intracellular membrane structures.
  • Contains 1 KIND domain.
  • Contains 3 WH2 domains.
Family:
  • Belongs to the spire family.
genes like me logo Genes that share domains with SPIRE2: view

No data available for Gene Families for SPIRE2 Gene

Function for SPIRE2 Gene

Molecular function for SPIRE2 Gene

UniProtKB/Swiss-Prot Function:
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.

Gene Ontology (GO) - Molecular Function for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with SPIRE2: view

Phenotypes for SPIRE2 Gene

GenomeRNAi human phenotypes for SPIRE2:
genes like me logo Genes that share phenotypes with SPIRE2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPIRE2 Gene

Localization for SPIRE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPIRE2 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SPIRE2 Gene COMPARTMENTS Subcellular localization image for SPIRE2 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0005938 cell cortex IEA,ISS --
GO:0030659 cytoplasmic vesicle membrane IEA,ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

Pathways & Interactions for SPIRE2 Gene

genes like me logo Genes that share pathways with SPIRE2: view

Pathways by source for SPIRE2 Gene

1 KEGG pathway for SPIRE2 Gene
1 Qiagen pathway for SPIRE2 Gene

Interacting Proteins for SPIRE2 Gene

Gene Ontology (GO) - Biological Process for SPIRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA,ISS --
GO:0030036 actin cytoskeleton organization IEA,IMP 21620703
GO:0036089 cleavage furrow formation IEA,ISS --
GO:0040038 polar body extrusion after meiotic divisions IEA,ISS --
genes like me logo Genes that share ontologies with SPIRE2: view

No data available for SIGNOR curated interactions for SPIRE2 Gene

Drugs & Compounds for SPIRE2 Gene

(1) Drugs for SPIRE2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LATRUNCULIN B Experimental Pharma Target 0
genes like me logo Genes that share compounds with SPIRE2: view

Transcripts for SPIRE2 Gene

Unigene Clusters for SPIRE2 Gene

Spire homolog 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPIRE2 Gene

No ASD Table

Relevant External Links for SPIRE2 Gene

GeneLoc Exon Structure for
SPIRE2
ECgene alternative splicing isoforms for
SPIRE2

Expression for SPIRE2 Gene

mRNA expression in normal human tissues for SPIRE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SPIRE2 Gene

This gene is overexpressed in Brain - Cerebellum (x4.3), Pituitary (x4.3), Colon - Transverse (x4.2), and Brain - Cerebellar Hemisphere (x4.1).

Protein differential expression in normal tissues from HIPED for SPIRE2 Gene

This gene is overexpressed in Heart (47.7) and Placenta (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPIRE2 Gene



Protein tissue co-expression partners for SPIRE2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SPIRE2 Gene:

SPIRE2

SOURCE GeneReport for Unigene cluster for SPIRE2 Gene:

Hs.461786
genes like me logo Genes that share expression patterns with SPIRE2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SPIRE2 Gene

Orthologs for SPIRE2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPIRE2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SPIRE2 34
  • 84.85 (n)
  • 85.57 (a)
SPIRE2 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Spire2 34
  • 83.86 (n)
  • 86.85 (a)
Spire2 16
Spire2 35
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SPIRE2 34
  • 99.01 (n)
  • 98.51 (a)
SPIRE2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Spire2 34
  • 83.82 (n)
  • 86.99 (a)
cow
(Bos Taurus)
Mammalia SPIRE2 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SPIRE2 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SPIRE2 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SPIRE2 34
  • 74.23 (n)
  • 73.11 (a)
SPIRE2 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SPIRE2 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia spire2 34
  • 62.75 (n)
  • 62.95 (a)
Str.1771 34
zebrafish
(Danio rerio)
Actinopterygii spire2 34
  • 63.61 (n)
  • 61.05 (a)
spire2 35
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008101 34
  • 60.11 (n)
  • 49.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta spir 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8252 35
  • 26 (a)
OneToMany
Species where no ortholog for SPIRE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SPIRE2 Gene

ENSEMBL:
Gene Tree for SPIRE2 (if available)
TreeFam:
Gene Tree for SPIRE2 (if available)

Paralogs for SPIRE2 Gene

Paralogs for SPIRE2 Gene

(1) SIMAP similar genes for SPIRE2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SPIRE2: view

Variants for SPIRE2 Gene

Sequence variations from dbSNP and Humsavar for SPIRE2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3803688 -- 89,868,478(-) AGTTA(C/T)AGAAT intron-variant
rs3840852 -- 89,860,945(-) GCCCC(-/G)ATGTT intron-variant
rs9745545 -- 89,846,049(+) CCGCC(A/C)CCACG intron-variant
rs9746953 -- 89,846,312(+) ctgag(C/G)cactg intron-variant
rs9928396 -- 89,839,440(+) AGGAG(C/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPIRE2 Gene

Variant ID Type Subtype PubMed ID
dgv1389n106 CNV deletion 24896259
dgv5324n54 CNV loss 21841781
dgv5325n54 CNV loss 21841781
dgv5326n54 CNV loss 21841781
dgv5327n54 CNV loss 21841781
dgv5328n54 CNV loss 21841781
dgv5329n54 CNV loss 21841781
dgv5330n54 CNV loss 21841781
dgv5331n54 CNV loss 21841781
dgv5332n54 CNV loss 21841781
dgv5333n54 CNV gain+loss 21841781
dgv5334n54 CNV loss 21841781
dgv5335n54 CNV loss 21841781
dgv63e180 CNV loss 20482838
esv1005255 CNV deletion 20482838
esv1071043 CNV insertion 17803354
esv23219 CNV gain+loss 19812545
esv2501942 CNV insertion 19546169
esv2657578 CNV deletion 23128226
esv2663404 CNV deletion 23128226
esv2668309 CNV deletion 23128226
esv2758671 CNV loss 17122850
esv2762221 CNV gain+loss 21179565
esv29066 CNV loss 19812545
esv3180457 CNV deletion 24192839
esv32652 CNV loss 17666407
esv3385098 CNV duplication 20981092
esv3553914 CNV deletion 23714750
esv3553915 CNV deletion 23714750
esv3639600 CNV loss 21293372
esv3639601 CNV loss 21293372
esv993879 CNV deletion 20482838
nsv1059577 CNV loss 25217958
nsv1070370 CNV deletion 25765185
nsv1071317 CNV deletion 25765185
nsv428331 CNV gain+loss 18775914
nsv457623 CNV gain 19166990
nsv457624 CNV loss 19166990
nsv482951 CNV loss 15286789
nsv573743 CNV gain 21841781
nsv573744 CNV loss 21841781
nsv573770 CNV loss 21841781
nsv573791 CNV loss 21841781
nsv573798 CNV gain+loss 21841781
nsv573799 CNV gain 21841781
nsv573810 CNV loss 21841781
nsv833331 CNV gain+loss 17160897
nsv9478 CNV loss 18304495

Variation tolerance for SPIRE2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.58; 72.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPIRE2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SPIRE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SPIRE2 Gene

Disorders for SPIRE2 Gene

Relevant External Links for SPIRE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SPIRE2

No disorders were found for SPIRE2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPIRE2 Gene

Publications for SPIRE2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 65
  2. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. (PMID: 21620703) Pfender S. … Schuh M. (Curr. Biol. 2011) 3 4 65
  3. Membrane targeting of the SpirA^formin actin nucleator complex requires a sequential handshake of polar interactions. (PMID: 25564607) Tittel J. … Kerkhoff E. (J. Biol. Chem. 2015) 3 65
  4. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-A1 that promotes efficient DNA repair. [corrected]. (PMID: 26287480) Belin B.J. … Mullins R.D. (Elife 2015) 3 65
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 65

Products for SPIRE2 Gene

Sources for SPIRE2 Gene

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