Aliases for SPIRE1 Gene
External Ids for SPIRE1 Gene
Previous GeneCards Identifiers for SPIRE1 Gene
Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SPIRE1 Gene
SPIRE1 (Spire-Type Actin Nucleation Factor 1) is a Protein Coding gene. Diseases associated with SPIRE1 include smallpox. Among its related pathways are TGF-Beta Pathway and Dorso-ventral axis formation. GO annotations related to this gene include actin binding. An important paralog of this gene is SPIRE2.
UniProtKB/Swiss-Prot for SPIRE1 Gene
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.