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Aliases for SPINT4 Gene

Aliases for SPINT4 Gene

  • Serine Peptidase Inhibitor, Kunitz Type 4 2 3 5
  • C20orf137 3 4
  • Serine Protease Inhibitor, Kunitz Type 1 3
  • Serine Protease Inhibitor, Kunitz Type 4 3
  • Chromosome 20 Open Reading Frame 137 2
  • DJ601O1.1 3
  • SPINT3 3

External Ids for SPINT4 Gene

Previous HGNC Symbols for SPINT4 Gene

  • C20orf137

Previous GeneCards Identifiers for SPINT4 Gene

  • GC00U901027
  • GC20P043785
  • GC20P044350
  • GC20P041092

Summaries for SPINT4 Gene

GeneCards Summary for SPINT4 Gene

SPINT4 (Serine Peptidase Inhibitor, Kunitz Type 4) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINT4 Gene

Genomics for SPINT4 Gene

Regulatory Elements for SPINT4 Gene

Enhancers for SPINT4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SPINT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SPINT4 Gene

45,722,349 bp from pter
45,725,830 bp from pter
3,482 bases
Plus strand

Genomic View for SPINT4 Gene

Genes around SPINT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SPINT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SPINT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINT4 Gene

Proteins for SPINT4 Gene

  • Protein details for SPINT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kunitz-type protease inhibitor 4
    Protein Accession:
    Secondary Accessions:
    • Q9BQN3

    Protein attributes for SPINT4 Gene

    99 amino acids
    Molecular mass:
    11421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINT4 Gene

Proteomics data for SPINT4 Gene at MOPED

Post-translational modifications for SPINT4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SPINT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINT4 Gene

Domains & Families for SPINT4 Gene

Protein Domains for SPINT4 Gene


Suggested Antigen Peptide Sequences for SPINT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Contains 1 BPTI/Kunitz inhibitor domain.
genes like me logo Genes that share domains with SPINT4: view

No data available for Gene Families for SPINT4 Gene

Function for SPINT4 Gene

Phenotypes for SPINT4 Gene

GenomeRNAi human phenotypes for SPINT4:
genes like me logo Genes that share phenotypes with SPINT4: view

Animal Model Products

miRNA for SPINT4 Gene

miRTarBase miRNAs that target SPINT4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SPINT4 Gene

Localization for SPINT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINT4 Gene


Subcellular locations from

Jensen Localization Image for SPINT4 Gene COMPARTMENTS Subcellular localization image for SPINT4 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for SPINT4 Gene

Pathways & Interactions for SPINT4 Gene

SuperPathways for SPINT4 Gene

No Data Available

Interacting Proteins for SPINT4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000279058 for SPINT4 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SPINT4 Gene


No data available for Pathways by source and SIGNOR curated interactions for SPINT4 Gene

Drugs & Compounds for SPINT4 Gene

No Compound Related Data Available

Transcripts for SPINT4 Gene

mRNA/cDNA for SPINT4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINT4 Gene

Serine peptidase inhibitor, Kunitz type 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SPINT4 Gene

No ASD Table

Relevant External Links for SPINT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINT4 Gene

mRNA expression in normal human tissues for SPINT4 Gene

Protein differential expression in normal tissues from HIPED for SPINT4 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SPINT4 Gene

SOURCE GeneReport for Unigene cluster for SPINT4 Gene Hs.677891

genes like me logo Genes that share expression patterns with SPINT4: view

Protein tissue co-expression partners for SPINT4 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SPINT4 Gene

Orthologs for SPINT4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SPINT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia SPINT4 35
  • 85.47 (n)
  • 75.64 (a)
  • 68 (a)
(Mus musculus)
Mammalia Spint4 35
  • 70.75 (n)
  • 58.16 (a)
Spint4 16
Spint4 36
  • 36 (a)
(Pan troglodytes)
Mammalia SPINT4 35
  • 99.66 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia SPINT4 36
  • 54 (a)
Species with no ortholog for SPINT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SPINT4 Gene

Gene Tree for SPINT4 (if available)
Gene Tree for SPINT4 (if available)

Paralogs for SPINT4 Gene

(6) SIMAP similar genes for SPINT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SPINT4: view

No data available for Paralogs for SPINT4 Gene

Variants for SPINT4 Gene

Sequence variations from dbSNP and Humsavar for SPINT4 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6017667 - 45,723,981(+) TCTCC(A/G)GCTGT reference, missense
rs16990631 - 45,722,456(+) AATTG(A/C/T)GGAGA reference, missense
rs232259 -- 45,725,748(-) AAACA(G/T)ATGGA downstream-variant-500B
rs232260 -- 45,725,026(-) attga(G/T)atata intron-variant
rs232261 -- 45,723,021(-) ACTTG(A/G)AGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SPINT4 Gene

Variant ID Type Subtype PubMed ID
esv2751915 CNV Loss 17911159
nsv458986 CNV Loss 19166990
esv2678145 CNV Deletion 23128226
esv33602 CNV Loss 17666407
esv2751916 CNV Loss 17911159
esv24579 CNV Loss 19812545
nsv514940 CNV Complex 21397061
esv23805 CNV Gain 19812545

Variation tolerance for SPINT4 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SPINT4 Gene

Disorders for SPINT4 Gene

Relevant External Links for SPINT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SPINT4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINT4 Gene

Publications for SPINT4 Gene

  1. Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein products. (PMID: 21988899) Clauss A. … Lundwall A.8. (BMC Biochem. 2011) 2 3 67
  2. Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans. (PMID: 21536719) Ferreira Z. … Seixas S. (Mol. Biol. Evol. 2011) 3

Products for SPINT4 Gene

Sources for SPINT4 Gene