SPINT4 Gene
protein-coding GIFtS: 34
GCID: GC20P044350
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serine peptidase inhibitor, Kunitz type 4(Previous names: chromosome 20 open reading frame 137, serine peptidase...)
(Previous symbol: C20orf137)
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Aliases
for SPINT4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Serine Peptidase Inhibitor, Kunitz Type 41 2 | | SPINT32 | | C20orf1371 2 3 | | Kunitz-Type Protease Inhibitor 42 | | DJ601O1.11 | | Serine Protease Inhibitor, Kunitz Type 12 | | Chromosome 20 Open Reading Frame 1371 | | Serine Protease Inhibitor, Kunitz Type 42 |
Export aliases for SPINT4 gene to outside databasesPrevious GC identifers: GC00U901027 GC20P043785 GC20P041092 |
Summaries
for SPINT4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SPINT4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SPINT4 gene promoter:
AhR GATA-3 Brachyury Pax-6 Arnt GATA-1 GATA-2 Gfi-1 STAT3 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for SPINT4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINT4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12SPINT4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P044350: view genomic region
(about GC identifiers)
Start:
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44,350,988 bp from pter |
End:
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44,354,469 bp from pter |
Size:
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3,482 bases |
Orientation:
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plus strand |
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Proteins
for SPINT4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: SPIT4_HUMAN, Q6UDR6 (See
protein sequence)Recommended Name: Kunitz-type protease inhibitor 4 precursor Size: 99 amino acids; 11421 Da
Subcellular location: Secreted (Probable)
Secondary accessions: Q9BQN3Explore the universe of human proteins at neXtProt for SPINT4: NX_Q6UDR6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UDR6
SPINT4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848550.1
ENSEMBL proteins: ENSP00000279058
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005576 | extracellular region |
IEA | -- |
SPINT4 for ontologies About GeneDecksing
SPINT4 Antibody Products:
Assay Products for SPINT4: |
Protein
Domains /
Families
for SPINT4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SPINT4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UDR6ProtoNet protein and cluster: Q6UDR6 UniProtKB/Swiss-Prot: SPIT4_HUMAN, Q6UDR6Similarity: Contains 1 BPTI/Kunitz inhibitor domain |
Function
for SPINT4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINT4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SPINT4 (NM_178455) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPINT4 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPINT4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004867 | serine-type endopeptidase inhibitor activity |
IEA | -- |
SPINT4 for ontologies About GeneDecksing
|
Pathways & Interactions
for SPINT4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPINT4
|
Drugs & Compounds
for SPINT4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SPINT4
Search CenterWatch for drugs/clinical trials and news about SPINT4 / SPIT4
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Transcripts
for SPINT4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for SPINT4 gene: NM_178455.1 Unigene Cluster for SPINT4: Serine peptidase inhibitor, Kunitz type 4 Hs.677891 [show with all ESTs]Unigene Representative Sequence: BI8275641 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000279058(uc002xpe.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINT4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINT4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SPINT4 (NM_178455) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SPINT4 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPINT4 |
Additional cDNA sequence: AY372173.1 AY372174.1 1 DOTS entry: DT.102842120 4 AceView cDNA sequences: AY372173 AY372174 AW303354 BI827564
GeneLoc Exon Structure
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Expression
for SPINT4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SPINT4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATTTTGGAA
About this image
See SPINT4 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.677891
SABiosciences Custom PCR Arrays for SPINT4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINT4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SPINT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINT4 |
Orthologs
for SPINT4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for SPINT4 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Spint41 , 5 |
serine protease inhibitor, Kunitz type 41, 5 |
70.75(n)1
58.16(a)1 |
|
2 (85.26 cM)5
782391 NM_030058.21 NP_084334.11
1646985015 |
ENSEMBL Gene Tree for SPINT4 (if available)
TreeFam Gene Tree for SPINT4 (if available) |
Paralogs
for SPINT4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for SPINT4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SPINT4 (44350988 - 44354469 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for SPINT4
5 CNVs: 67700 9321 9320 67701 7307 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINT4 |
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Disorders
/ Diseases
for SPINT4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SPINT4 for disorders About GeneDecksing
1  disease for SPINT4: About MalaCardsepididymitis
Export disorders for SPINT4 gene to outside databases
|
Publications
for SPINT4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SPINT4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPINT4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Three genes expressing Kunitz domains in the epididym is are related to genes of WFDC-type protease inhibitors and semen coagulum pro teins in spite of lacking similarity between their protein products. (PubMed id 21988899)1, 3 Clauss A....Lundwall A.8. (2011)
- Differing evolutionary histories of WFDC8 (short-term balancing) in Europeans and SPINT4 (incomplete selective sweep) in Africans. (PubMed id 21536719)1 Ferreira Z....Seixas S. (2011)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)2 Deloukas P....Rogers J. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for SPINT4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SPINT4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing SPINT4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SPINT4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SPINT4 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for SPINT4 gene:
Search GeneIP for patents involving SPINT4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SPINT4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SPINT4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SPINT4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SPINT4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SPINT4 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SPINT4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SPINT4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SPINT4 | | OriGene Custom Protein Services for SPINT4 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SPINT4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SPINT4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINT4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SPINT4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINT4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SPINT4 |
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 |  |  |  | |
| | | | Search Tocris compounds for SPINT4 |
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 | | | SPINT4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for SPINT4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPINT4 |
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