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Aliases for SPINT3 Gene

Aliases for SPINT3 Gene

  • Serine Peptidase Inhibitor, Kunitz Type, 3 2 3
  • Serine Protease Inhibitor, Kunitz Type, 3 2 3
  • HKIB9 3 4
  • Serine Protease Inhibitor Kunitz Type 3 3

External Ids for SPINT3 Gene

Previous GeneCards Identifiers for SPINT3 Gene

  • GC20M043869
  • GC20M043829
  • GC20M044779
  • GC20M044826
  • GC20M043574
  • GC20U900207
  • GC20M044141
  • GC20M040882

Summaries for SPINT3 Gene

GeneCards Summary for SPINT3 Gene

SPINT3 (Serine Peptidase Inhibitor, Kunitz Type, 3) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is TFPI.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SPINT3 Gene

Genomics for SPINT3 Gene

Regulatory Elements for SPINT3 Gene

Genomic Location for SPINT3 Gene

45,512,461 bp from pter
45,515,624 bp from pter
3,164 bases
Minus strand

Genomic View for SPINT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SPINT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SPINT3 Gene

Proteins for SPINT3 Gene

  • Protein details for SPINT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Kunitz-type protease inhibitor 3
    Protein Accession:
    Secondary Accessions:
    • A6NCQ6
    • Q6UDR8
    • Q96KK2

    Protein attributes for SPINT3 Gene

    89 amino acids
    Molecular mass:
    10252 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SPINT3 Gene

Proteomics data for SPINT3 Gene at MOPED

Post-translational modifications for SPINT3 Gene

No Post-translational modifications

Other Protein References for SPINT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SPINT3 Gene

Domains & Families for SPINT3 Gene

Protein Domains for SPINT3 Gene

Suggested Antigen Peptide Sequences for SPINT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BPTI/Kunitz inhibitor domain.
  • Contains 1 BPTI/Kunitz inhibitor domain.
genes like me logo Genes that share domains with SPINT3: view

No data available for Gene Families for SPINT3 Gene

Function for SPINT3 Gene

Gene Ontology (GO) - Molecular Function for SPINT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with SPINT3: view

Phenotypes for SPINT3 Gene

GenomeRNAi human phenotypes for SPINT3:
genes like me logo Genes that share phenotypes with SPINT3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPINT3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SPINT3 Gene

Localization for SPINT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SPINT3 Gene


Subcellular locations from

Jensen Localization Image for SPINT3 Gene COMPARTMENTS Subcellular localization image for SPINT3 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SPINT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with SPINT3: view

Pathways & Interactions for SPINT3 Gene

SuperPathways for SPINT3 Gene

No Data Available

Interacting Proteins for SPINT3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000217428 for SPINT3 Gene via STRING

Gene Ontology (GO) - Biological Process for SPINT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with SPINT3: view

No data available for Pathways by source and SIGNOR curated interactions for SPINT3 Gene

Drugs & Compounds for SPINT3 Gene

No Compound Related Data Available

Transcripts for SPINT3 Gene

mRNA/cDNA for SPINT3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SPINT3 Gene

Serine peptidase inhibitor, Kunitz type, 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SPINT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SPINT3 Gene

No ASD Table

Relevant External Links for SPINT3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SPINT3 Gene

mRNA expression in normal human tissues for SPINT3 Gene

mRNA differential expression in normal tissues according to GTEx for SPINT3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.8) and Skin - Sun Exposed (Lower leg) (x18.4).

SOURCE GeneReport for Unigene cluster for SPINT3 Gene Hs.370724

genes like me logo Genes that share expression patterns with SPINT3: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SPINT3 Gene

Orthologs for SPINT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SPINT3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SPINT3 35
  • 98.5 (n)
  • 95.51 (a)
  • 96 (a)
(Mus musculus)
Mammalia Spint3 16
Spint3 36
  • 28 (a)
(Bos Taurus)
Mammalia -- 36
  • 24 (a)
(Canis familiaris)
Mammalia ELP 36
  • 23 (a)
(Monodelphis domestica)
Mammalia ELP 36
  • 12 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 12 (a)
(Anolis carolinensis)
Reptilia SPINT3 36
  • 3 (a)
(Danio rerio)
Actinopterygii wu:fb59d01 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea F22E12.1 36
  • 3 (a)
mec-1 36
  • 1 (a)
mec-9 36
  • 3 (a)
ZK287.4 36
  • 2 (a)
Species with no ortholog for SPINT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SPINT3 Gene

Gene Tree for SPINT3 (if available)
Gene Tree for SPINT3 (if available)

Paralogs for SPINT3 Gene

Paralogs for SPINT3 Gene

(14) SIMAP similar genes for SPINT3 Gene using alignment to 1 proteins: Pseudogenes for SPINT3 Gene

genes like me logo Genes that share paralogs with SPINT3: view

Variants for SPINT3 Gene

Sequence variations from dbSNP and Humsavar for SPINT3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs4812907 -- 45,512,052(+) CAGGA(C/T)GGTCT downstream-variant-500B
rs6017591 -- 45,512,401(+) CTAAA(C/T)TTCCC downstream-variant-500B
rs6032258 -- 45,512,410(+) CCCAG(C/T)GTATT downstream-variant-500B
rs6032259 - 45,512,691(+) TCCTC(A/G)AAAAG missense, reference
rs6032260 -- 45,513,735(+) CACCA(C/T)GTGGG intron-variant

Variation tolerance for SPINT3 Gene

Gene Damage Index Score: 3.98; 60.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SPINT3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SPINT3 Gene

Disorders for SPINT3 Gene

Relevant External Links for SPINT3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SPINT3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SPINT3 Gene

Publications for SPINT3 Gene

  1. Three genes expressing Kunitz domains in the epididymis are related to genes of WFDC-type protease inhibitors and semen coagulum proteins in spite of lacking similarity between their protein products. (PMID: 21988899) Clauss A. … Lundwall A.8. (BMC Biochem. 2011) 2 67
  2. Voxelwise genome-wide association study (vGWAS). (PMID: 20171287) Stein J.L. … Thompson P. (Neuroimage 2010) 67
  3. A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis. (PMID: 17589793) Lundwall A. (Asian J. Androl. 2007) 67
  4. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N. … van Dorsselaer A. (Proteomics 2003) 67
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 67

Products for SPINT3 Gene

Sources for SPINT3 Gene

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