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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SPINT3 Gene

protein-coding   GIFtS: 38
GCID: GC20M044141

Serine Peptidase Inhibitor, Kunitz Type, 3

(Previous names: serine protease inhibitor, Kunitz type, 3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Serine Peptidase Inhibitor, Kunitz Type, 31 2
Serine Protease Inhibitor, Kunitz Type, 31 2
HKIB92 3
Kunitz-Type Protease Inhibitor 32
Serine Protease Inhibitor Kunitz Type 32

External Ids:    HGNC: 112481   Entrez Gene: 108162   Ensembl: ENSG000001014467   OMIM: 6139415   UniProtKB: P492233   

Export aliases for SPINT3 gene to outside databases

Previous GC identifers: GC20M043869 GC20M043829 GC20M044779 GC20M044826 GC20M043574 GC20U900207 GC20M040882


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SPINT3 Gene: 
SPINT3 (serine peptidase inhibitor, Kunitz type, 3) is a protein-coding gene. Diseases associated with SPINT3 include epididymitis, and pancreatitis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SPINT2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SPINT3 gene promoter:
         FAC1   RFX1   FOXJ2 (long isoform)   Nkx2-2   FOXJ2   Nkx2-5   GATA-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for SPINT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SPINT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12-q13.1   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q12-q13.2

SPINT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SPINT3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M044141:  view genomic region     (about GC identifiers)

Start:
44,141,101 bp from pter      End:
44,144,264 bp from pter
Size:
3,164 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: SPIT3_HUMAN, P49223 (See protein sequence)
Recommended Name: Kunitz-type protease inhibitor 3 precursor  
Size: 89 amino acids; 10252 Da
Subcellular location: Secreted (Probable)
Secondary accessions: A6NCQ6 Q6UDR8 Q96KK2

Explore the universe of human proteins at neXtProt for SPINT3: NX_P49223

Explore proteomics data for SPINT3 at MOPED 

SPINT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

SPINT3 Protein Expression

REFSEQ proteins: NP_006643.1  
ENSEMBL proteins: 
 ENSP00000217428  

Human Recombinant Protein Products for SPINT3: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

SPINT3 for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for SPINT3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
2 InterPro protein domains:
 IPR002223 Prot_inh_Kunz-m
 IPR020901 Prtase_inh_Kunz-CS

Graphical View of Domain Structure for InterPro Entry P49223

ProtoNet protein and cluster: P49223

1 Blocks protein domain: IPB002223 Pancreatic trypsin inhibitor (Kunitz)

UniProtKB/Swiss-Prot: SPIT3_HUMAN, P49223
Similarity: Contains 1 BPTI/Kunitz inhibitor domain


SPINT3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004867serine-type endopeptidase inhibitor activity IEA--
     
SPINT3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for SPINT3:
 Increased S DNA content, incre 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SPINT3

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for SPINT3 (ENSP000002174284) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TAF10ENSP000002994244STRING: ENSP00000299424
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SPINT3 (SPIT3)

Search CenterWatch for drugs/clinical trials and news about SPINT3 / SPIT3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SPINT3 gene: 
NM_006652.1  

Unigene Cluster for SPINT3:

Serine peptidase inhibitor, Kunitz type, 3
Hs.370724  [show with all ESTs]
Unigene Representative Sequence: NM_006652
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000217428(uc010ghg.1)
miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SPINT3

Additional mRNA sequence: AY372172.2 

1 DOTS entry:

DT.40307068 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SPINT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GATTCGGGAT
SPINT3 Expression
About this image


See SPINT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SPINT3

SOURCE GeneReport for Unigene cluster: Hs.370724
    SABiosciences Custom PCR Arrays for SPINT3
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SPINT3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for SPINT3 gene from 3/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Spint31 , 5 serine peptidase inhibitor, Kunitz type, 31, 5 60.61(n)1
43.18(a)1
  2 (85.20 cM)5
6297471  NM_001177401.11  NP_001170872.11 
 1645696955 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 5)
Uncharacterized protein
(see all 5)
38(a)
27(a)
(see all 5)
many ↔ many
many ↔ many
(see all 5)
GL343322.1(954179-956235)
GL343322.1(995852-996850)
zebrafish
(Danio rerio)
Actinopterygii spint26
serine peptidase inhibitor, Kunitz type, 2
5(a)
possible ortholog
15(19200783-19212158)


ENSEMBL Gene Tree for SPINT3 (if available)
TreeFam Gene Tree for SPINT3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SPINT3 gene
SPINT22  WFIKKN22  AMBP2  SPINT12  TFPI22  WFIKKN12  TFPI2  
14 SIMAP similar genes for SPINT3 using alignment to 1 protein entry:     SPIT3_HUMAN:
WFIKKN2    ITIL    COL6A3    EPPIN    TFPI    AMBP
COL28A1    SPINT2    TFPI2    PAPLN    WFDC8    APLP2
APP    SPINT1

SPINT3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for SPINT3
PGOHUM00000261993


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/122 SNPs in SPINT3 are shown (see all 122)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs48129071,2
C,F,A--44140692(+) CAGGAC/TGGTCT 1 -- int12Minor allele frequency- T:0.50NA 4
rs600019611,2
C,F--44140758(+) TTACAG/CGTGTG 1 -- int11Minor allele frequency- C:0.50WA 2
rs711818311,2
C--44140787(+) TTTTT-/TTAATTA 1 -- int11Minor allele frequency- TT:0.00NA 2
rs1119243221,2
F--44140912(+) CCCCTC/TCTTGT 1 -- int11Minor allele frequency- T:0.50CSA 2
rs1471188291,2
--44140915(+) CTCCTC/TGTCCA 1 -- int10--------
rs733059491,2
C,F--44140947(+) TACCCG/AAATTT 1 -- int12Minor allele frequency- A:0.12WA 120
rs787760481,2
C,F--44140986(+) CCTTTA/CTCTCC 1 -- int11Minor allele frequency- C:0.08EA 120
rs1908833071,2
--44140988(+) TTTATC/TTCCCA 1 -- int10--------
rs786266411,2
C,F--44140989(+) TTATCT/CCCCAG 1 -- int11Minor allele frequency- C:0.08EA 120
rs1385171741,2
--44141010(+) AGTAAC/TTCATA 1 -- int10--------

HapMap Linkage Disequilibrium report for SPINT3 (44141101 - 44144264 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for SPINT3: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing SPINT3
DNA2.0 Custom Variant and Variant Library Synthesis for SPINT3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 613941    OMIM disorders: --

2 diseases for SPINT3:    About MalaCards
epididymitis    pancreatitis


SPINT3 for disorders           About GeneDecksing

Genetic Association Database (GAD): SPINT3

Export disorders for SPINT3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for SPINT3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SPINT3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Three genes expressing Kunitz domains in the epididym is are related to genes of WFDC-type protease inhibitors and semen coagulum pro teins in spite of lacking similarity between their protein products. (PubMed id 21988899)1, 3 Clauss A....Lundwall A.8. (2011)
  2. Voxelwise genome-wide association study (vGWAS). (PubMed id 20171287)1, 4 Stein J.L....Thompson P. (2010)
  3. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  4. A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis. (PubMed id 17589793)1 Lundwall A. (2007)
  5. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1 Cavusoglu N.... van Dorsselaer A. (2003)
  6. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PubMed id 11549316)1 Fossey S.C....Bowden D.W. (2001)
  7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10816 HGNC: 11248 Ensembl:ENSG00000101446 euGenes: HUgn10816 ECgene: SPINT3
H-InvDB: SPINT3

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for SPINT3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for SPINT3 gene:
Search GeneIP for patents involving SPINT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat SPINT3
 inGenious Targeting Laboratory - Custom generated mouse model solutions for SPINT3
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SPINT3
Customized:
 lentivirus for stable overexpression of SPINT3
 lentivirus expression plasmids for stable overexpression of SPINT3
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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